MCM8 Gene
protein-coding GIFtS: 54
GCID: GC20P005926
|
|
minichromosome maintenance complex component 8(Previous name: chromosome 20 open reading frame 154 )
(Previous symbol: C20orf154)
| |
Aliases
for MCM8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Minichromosome Maintenance Complex Component 81 2 | | MGC48161 | | C20orf1541 2 3 | | Chromosome 20 Open Reading Frame 1541 | | REC1 2 | | DNA Helicase MCM82 | | DJ967N21.51 | | DNA Replication Licensing Factor MCM82 | | Minichromosome Maintenance 82 3 | | MCM8 Minichromosome Maintenance Deficient 82 | | MGC1195221 | | REC Homolog2 | | MGC1195231 | | EC 3.6.4.123 | | MGC128661 | | |
Export aliases for MCM8 gene to outside databasesPrevious GC identifer: GC20P005879 |
Summaries
for MCM8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MCM8:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that areessential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCMproteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation ofreplication forks and in the recruitment of other DNA replication related proteins. This protein contains the centraldomain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternativelyspliced transcript variants encoding distinct isoforms have been described. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MCM8_HUMAN, Q9UJA3Function: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNAinterstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexamerichelicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks intohomologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization andfork restart. May also play a non-essential for DNA replication: may be involved in the activation of theprereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Bindschromatin throughout the cell cycle
Gene Wiki entry for MCM8
|
Genomic Views
for MCM8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MCM8 gene promoter:
RFX1 p53 AML1a HOXA3 POU3F1 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for MCM8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCM8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p12.3 Ensembl cytogenetic band: 20p12.3 HGNC cytogenetic band: 20p12.3MCM8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P005926: view genomic region
(about GC identifiers)
Start:
|
5,931,298 bp from pter |
End:
|
5,975,852 bp from pter |
Size:
|
44,555 bases |
Orientation:
|
plus strand |
|
Proteins
for MCM8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MCM8_HUMAN, Q9UJA3 (See
protein sequence)Recommended Name: DNA helicase MCM8 Size: 840 amino acids; 93697 Da
Subunit: Component of the MCM8-MCM9 complex, which forms a hexamer composed of MCM8 and MCM9. Interacts with CDC6 andORC2
Subcellular location: Nucleus. Note=Localizes to nuclear foci and colocalizes with RAD51
Caution: Was initially thought to play a role in DNA replication (PubMed:15684404). However, it was later shown that itis mainly involved in homologous recombination repair (PubMed:22771115)
Sequence caution: Sequence=BAB55260.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RBG7 D3DW08 E7EQU7 Q495R4 Q495R6 Q495R7 Q86US4 Q969I5Alternative splicing: 4 isoforms: Q9UJA3-1 Q9UJA3-2 Q9UJA3-3 Q9UJA3-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MCM8: NX_Q9UJA3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UJA3
MCM8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_115874.3 NP_877954.1
ENSEMBL proteins: ENSP00000368174 ENSP00000265187 ENSP00000368161 ENSP00000368164 Reactome Protein details: Q9UJA3
Human Recombinant Protein Products for MCM8:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005654 | nucleoplasm |
TAS | -- | | GO:0097362 | MCM8-MCM9 complex |
IDA | -- |
MCM8 for ontologies About GeneDecksing
MCM8 Antibody Products:
Assay Products for MCM8: |
Protein
Domains /
Families
for MCM8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MCM8 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UJA3ProtoNet protein and cluster: Q9UJA3 1 Blocks protein family: IPB001208 MCM family
UniProtKB/Swiss-Prot: MCM8_HUMAN, Q9UJA3Similarity: Belongs to the MCM familySimilarity: Contains 1 MCM domain |
Function
for MCM8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MCM8_HUMAN, Q9UJA3Function: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNAinterstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexamerichelicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks intohomologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization andfork restart. May also play a non-essential for DNA replication: may be involved in the activation of theprereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Bindschromatin throughout the cell cycleCatalytic activity: ATP + H(2)O = ADP + phosphateInduction: By E2F1 Enzyme Number (IUBMB): EC 3.6.4.121
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
MCM8 for ontologies About GeneDecksing
Phenotypes:
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Mcm8):
MCM8 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Mcm8tm1.1Geno for MCM8
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCM8 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCM8 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MCM8 (NM_032485) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MCM8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCM8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM8 |
|
Pathways & Interactions
for MCM8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ubiquitinated Orc1 is degraded by the proteasome | | | 2 | Activation of ATR in response to replication stress | | | 3 | CDC6 association with the ORC:origin complex | | | 4 | Cell Cycle | | | 5 | G1/S Transition | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MCM8
5/25 
Reactome Pathways for MCM8 (see all 25)
MCM8 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MCM8
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/14 Interacting proteins for MCM8 (Q9UJA33 ENSP000003681744) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000075 | cell cycle checkpoint |
TAS | -- | | GO:0000082 | G1/S transition of mitotic cell cycle |
TAS | -- | | GO:0000084 | S phase of mitotic cell cycle |
TAS | -- | | GO:0000216 | M/G1 transition of mitotic cell cycle |
TAS | -- | | GO:0000278 | mitotic cell cycle |
TAS | -- |
MCM8 for ontologies About GeneDecksing
|
Drugs & Compounds
for MCM8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MCM8
Search CenterWatch for drugs/clinical trials and news about MCM8
|
Transcripts
for MCM8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MCM8 gene (2 alternative transcripts): NM_032485.4 NM_182802.1 Unigene Cluster for MCM8: Minichromosome maintenance complex component 8 Hs.597484 [show with all ESTs]Unigene Representative Sequence: NM_1828024 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378896(uc002wmi.3 uc002wmj.3 uc002wmk.3 uc002wml.3 uc010gbp.3)
ENST00000265187(uc002wmm.3) ENST00000378883 ENST00000378886
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCM8 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCM8 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MCM8 (NM_032485) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MCM8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCM8 |
Additional cDNA sequence: AJ439063.1 AK027644.1 AK297806.1 AK314654.1 AY158211.1 BC005170.1 BC008830.2 BC080656.1 BC101054.1 BC101055.1 BC101056.1 BC101057.1 5 DOTS entries: DT.100778920 DT.112513 DT.91762513 DT.120833354 DT.99984722 24/124 AceView cDNA sequences (see all 124): AU125903 AI078438 BQ007416 R10261 AI081701 AW963925 AA609373 BM558689 AA379359 AA193063 BQ441929 BM904262 BX504348 BQ049652 BM808016 BU162199 AI913762 BU509003 AA370141 AV645497 AK022738 BF509125 BX282225 BM808018
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MCM8 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | |
| ExUns: | 21a | · | 21b |
|---|
|
| SP1: | | | | | |
| SP2: | | | | | |
| SP3: | | | | | |
| SP4: | | | | | |
| SP5: | | | | |
ECgene alternative splicing isoforms for MCM8
|
Expression
for MCM8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MCM8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTCTGGAAT
About this image
See MCM8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MCM8
SOURCE GeneReport for Unigene cluster: Hs.597484
UniProtKB/Swiss-Prot: MCM8_HUMAN, Q9UJA3Tissue specificity: Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressedin various tumors with highest levels in colon and lung cancers
SABiosciences Custom PCR Arrays for MCM8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MCM8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MCM8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCM8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCM8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM8 |
Orthologs
for MCM8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MCM8 gene from 7/30 species (see all 30) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MCM81 |
minichromosome maintenance complex component 8 |
74.42(n)
79.39(a) |
|
421314 XM_001232578.1 XP_001232579.1 |
lizard
(Anolis carolinensis) |
Reptilia |
MCM86 |
-- |
79(a) |
1 ↔ 1 |
1(129363630-129387076) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.224882 |
Xenopus laevis transcribed sequence with weak similarity more |
73.9(n) |
|
48037082 |
zebrafish
(Danio rerio) |
Actinopterygii |
570619252 |
-- |
74.47(n) |
|
57061925 |
fruit fly
(Drosophila melanogaster) |
Insecta |
rec6 |
recombination-defective |
22(a) |
1 ↔ 1 |
3R(11648741-11658354) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
MCM81 |
minichromosome maintenance 8 |
54.72(n)
49.03(a) |
|
820123 NM_111800.2 NP_187577.1 |
rice
(Oryza sativa) |
Liliopsida |
Os05g04641001 |
hypothetical protein |
54.5(n)
48.84(a) |
|
4339038 NM_001062312.1 NP_001055777.1 |
ENSEMBL Gene Tree for MCM8 (if available)
TreeFam Gene Tree for MCM8 (if available) |
Paralogs
for MCM8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MCM8 gene
- MCM42
1 SIMAP similar gene for MCM8 using alignment to 1 protein entry: MCM8_HUMAN:FLJ00323
MCM8 for paralogs About GeneDecksing
|
Genomic Variants
for MCM8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MCM8 (5931298 - 5975852 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for MCM8
1 CNV: 102908
4 Indels: 12149 26869 61907 46115 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MCM8 |
|
Disorders
/ Diseases
for MCM8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MCM8 for disorders About GeneDecksing
OMIM gene information: 608187
OMIM disorders: --
9  diseases for MCM8: About MalaCardscri-du-chat syndrome wolf-hirschhorn syndrome gingival recession gingivitis
microcephaly periodontitis lung cancer neuroblastoma
malaria
1 disease from the University of Copenhagen DISEASES database for MCM8:Gingival recession Human Genome Epidemiology (HuGE) Navigator: MCM8 (6 documents)
Export disorders for MCM8 gene to outside databases
|
Publications
for MCM8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MCM8 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with MCM8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and functional characterization of a new member of the human Mcm protein family: hMcm8. (PubMed id 12527764)1, 2, 3 Gozuacik D.... Paterlini-Brechot P. (2003)
- A new member of the MCM protein family encoded by the human MCM8 gene, located contrapodal to GCD10 at chromosome band 20p12.3-13. (PubMed id 12771218)1, 2, 9 Johnson E.M.... Daniel D.C. (2003)
- Involvement of human MCM8 in prereplication complex assembly by recruiting hcdc6 to chromatin. (PubMed id 15684404)1, 2, 9 Volkening M. and Hoffmann I. (2005)
- Colocalization of MCM8 and MCM7 with proteins involved in distinct aspects of DNA replication. (PubMed id 18072282)1, 2 Kinoshita Y....Daniel D.C. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Comparative genomics on MCM8 orthologous genes reveals the transcriptional regulation by transcription factor E2F. (PubMed id 16325355)2, 9 Hayashi R....Yoshida K. (2006)
- Replication of loci influencing ages at menarche and m enopause in Hispanic women: the Women's Health Initiative SHARe Study. (PubMed id 22131368)1 Chen C.T....Franceschini N. (2012)
- Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks. (PubMed id 22771115)2 Nishimura K.... Kanemaki M.T. (2012)
|
External Searches for MCM8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MCM8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MCM8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MCM8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for MCM8 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MCM8 gene:
Search GeneIP for patents involving MCM8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MCM8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MCM8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCM8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MCM8 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MCM8 | | OriGene 3'-UTR Clone for MCM8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCM8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCM8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MCM8 | | OriGene Custom Protein Services for MCM8 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MCM8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MCM8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCM8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MCM8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCM8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCM8 |
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| | | | Search Tocris compounds for MCM8 |
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 | | | MCM8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM8 |
|  |  |  |  | | | | ThermoFisher Antibodies for MCM8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCM8 |
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