Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MCM8 Gene

Aliases for MCM8 Gene

  • Minichromosome Maintenance Complex Component 8 2 3
  • C20orf154 3 4
  • MCM8 Minichromosome Maintenance Deficient 8 3
  • DNA Replication Licensing Factor MCM8 3
  • Chromosome 20 Open Reading Frame 154 2
  • Minichromosome Maintenance 8 4
  • REC Homolog (Drosophila) 2
  • DNA Helicase MCM8 3
  • REC Homolog 3
  • EC 3.6.4.12 4
  • DJ967N21.5 3
  • POF10 3

External Ids for MCM8 Gene

Previous HGNC Symbols for MCM8 Gene

  • C20orf154

Previous GeneCards Identifiers for MCM8 Gene

  • GC20P005879

Summaries for MCM8 Gene

Entrez Gene Summary for MCM8 Gene

  • The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]

GeneCards Summary for MCM8 Gene

MCM8 (Minichromosome Maintenance Complex Component 8) is a Protein Coding gene. Diseases associated with MCM8 include gingival recession. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include helicase activity. An important paralog of this gene is MCM4.

UniProtKB/Swiss-Prot for MCM8 Gene

  • Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle.

Gene Wiki entry for MCM8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCM8 Gene

Genomics for MCM8 Gene

Regulatory Elements for MCM8 Gene

Genomic Location for MCM8 Gene

Start:
5,950,652 bp from pter
End:
5,995,894 bp from pter
Size:
45,243 bases
Orientation:
Plus strand

Genomic View for MCM8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCM8 Gene

Proteins for MCM8 Gene

  • Protein details for MCM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJA3-MCM8_HUMAN
    Recommended name:
    DNA helicase MCM8
    Protein Accession:
    Q9UJA3
    Secondary Accessions:
    • B2RBG7
    • D3DW08
    • E7EQU7
    • Q495R4
    • Q495R6
    • Q495R7
    • Q86US4
    • Q969I5

    Protein attributes for MCM8 Gene

    Size:
    840 amino acids
    Molecular mass:
    93697 Da
    Quaternary structure:
    • Component of the MCM8-MCM9 complex, which forms a hexamer composed of MCM8 and MCM9. Interacts with CDC6 and ORC2.
    SequenceCaution:
    • Sequence=BAB55260.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MCM8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCM8 Gene

Proteomics data for MCM8 Gene at MOPED

Post-translational modifications for MCM8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MCM8 Gene

No data available for DME Specific Peptides for MCM8 Gene

Domains for MCM8 Gene

Protein Domains for MCM8 Gene

Suggested Antigen Peptide Sequences for MCM8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJA3

UniProtKB/Swiss-Prot:

MCM8_HUMAN :
  • Q9UJA3
Domain:
  • Contains 1 MCM domain.
Family:
  • Belongs to the MCM family.
genes like me logo Genes that share domains with MCM8: view

No data available for Gene Families for MCM8 Gene

Function for MCM8 Gene

Molecular function for MCM8 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle.
UniProtKB/Swiss-Prot Induction: By E2F1.

Enzyme Numbers (IUBMB) for MCM8 Gene

Gene Ontology (GO) - Molecular Function for MCM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 22540012
GO:0005524 ATP binding IEA --
GO:0016851 magnesium chelatase activity --
genes like me logo Genes that share ontologies with MCM8: view
genes like me logo Genes that share phenotypes with MCM8: view

Animal Models for MCM8 Gene

MGI Knock Outs for MCM8:

miRNA for MCM8 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for MCM8 Gene

Localization for MCM8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCM8 Gene

Nucleus. Note=Localizes to nuclear foci and colocalizes with RAD51.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCM8 Gene COMPARTMENTS Subcellular localization image for MCM8 gene
Compartment Confidence
nucleus 5
extracellular 2
cytoskeleton 1
cytosol 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MCM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0097362 MCM8-MCM9 complex IDA 22771115
genes like me logo Genes that share ontologies with MCM8: view

Pathways for MCM8 Gene

genes like me logo Genes that share pathways with MCM8: view

Pathways by source for MCM8 Gene

Gene Ontology (GO) - Biological Process for MCM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0000724 double-strand break repair via homologous recombination IEA --
GO:0006260 DNA replication TAS --
GO:0006271 DNA strand elongation involved in DNA replication TAS --
genes like me logo Genes that share ontologies with MCM8: view

Transcripts for MCM8 Gene

Unigene Clusters for MCM8 Gene

Minichromosome maintenance complex component 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MCM8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^
SP1: - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: - - - -
SP6:
SP7: -

ExUns: 21a · 21b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for MCM8 Gene

GeneLoc Exon Structure for
MCM8
ECgene alternative splicing isoforms for
MCM8

Expression for MCM8 Gene

mRNA expression in normal human tissues for MCM8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCM8 Gene

SOURCE GeneReport for Unigene cluster for MCM8 Gene Hs.597484

mRNA Expression by UniProt/SwissProt for MCM8 Gene

Q9UJA3-MCM8_HUMAN
Tissue specificity: Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers.
genes like me logo Genes that share expressions with MCM8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MCM8 Gene

Orthologs for MCM8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCM8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCM8 35
  • 99.37 (n)
  • 99.29 (a)
MCM8 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MCM8 35
  • 91.91 (n)
  • 92.28 (a)
MCM8 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCM8 35
  • 92.32 (n)
  • 93.04 (a)
MCM8 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcm8 35
  • 87.12 (n)
  • 90.31 (a)
Mcm8 16
Mcm8 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCM8 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCM8 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcm8 35
  • 86.91 (n)
  • 90.72 (a)
chicken
(Gallus gallus)
Aves MCM8 35
  • 74.77 (n)
  • 79.75 (a)
MCM8 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCM8 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22488 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mcm8 35
  • 71.68 (n)
  • 77.15 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6835 35
zebrafish
(Danio rerio)
Actinopterygii LOC100333576 35
  • 67.24 (n)
  • 71.88 (a)
mcm8 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002580 35
  • 46.32 (n)
  • 41.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta rec 36
  • 26 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCM4 36
  • 22 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons MCM8 35
  • 54.58 (n)
  • 49.25 (a)
rice
(Oryza sativa)
Liliopsida Os05g0464100 35
  • 55.04 (n)
  • 49.61 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13919 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for MCM8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MCM8 Gene

ENSEMBL:
Gene Tree for MCM8 (if available)
TreeFam:
Gene Tree for MCM8 (if available)

Paralogs for MCM8 Gene

Paralogs for MCM8 Gene

Selected SIMAP similar genes for MCM8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MCM8: view

Variants for MCM8 Gene

Sequence variations from dbSNP and Humsavar for MCM8 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs180477 -- 5,987,098(+) CTGGG(A/T)TTATA intron-variant
rs236100 -- 5,968,060(-) TGCAT(C/T)TATGT intron-variant
rs236101 -- 5,968,066(-) CCAAC(A/G)TGCAT intron-variant
rs236102 -- 5,971,320(-) tttgg(A/C)taaca intron-variant
rs236103 -- 5,977,341(+) gagag(C/T)cacac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCM8 Gene

Variant ID Type Subtype PubMed ID
esv2453476 CNV Deletion 19546169
esv2244525 CNV Deletion 18987734
nsv179031 CNV Loss 16902084
esv2722144 CNV Deletion 23290073
esv1746393 CNV Deletion 17803354
esv7029 CNV Loss 19470904

Relevant External Links for MCM8 Gene

HapMap Linkage Disequilibrium report
MCM8
Human Gene Mutation Database (HGMD)
MCM8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCM8 Gene

Disorders for MCM8 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MCM8 Gene including...

Search for MCM8 Gene in MalaCards »

(1) University of Copenhagen DISEASES for MCM8 Gene

Relevant External Links for MCM8

Genetic Association Database (GAD)
MCM8
Human Genome Epidemiology (HuGE) Navigator
MCM8
genes like me logo Genes that share disorders with MCM8: view

No data available for UniProtKB/Swiss-Prot for MCM8 Gene

Publications for MCM8 Gene

  1. A new member of the MCM protein family encoded by the human MCM8 gene, located contrapodal to GCD10 at chromosome band 20p12.3-13. (PMID: 12771218) Johnson E.M. … Daniel D.C. (Nucleic Acids Res. 2003) 3 4 23
  2. Involvement of human MCM8 in prereplication complex assembly by recruiting hcdc6 to chromatin. (PMID: 15684404) Volkening M. … Hoffmann I. (Mol. Cell. Biol. 2005) 3 4 23
  3. Identification and functional characterization of a new member of the human Mcm protein family: hMcm8. (PMID: 12527764) Gozuacik D. … Paterlini-Brechot P. (Nucleic Acids Res. 2003) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for MCM8 Gene

Sources for MCM8 Gene

Back to Top

Content