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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MCM7 Gene

protein-coding   GIFtS: 71
GCID: GC07M099690

Minichromosome Maintenance Complex Component 7

(Previous names: minichromosome maintenance deficient (S. cerevisiae) 7,...)
(Previous symbol: MCM2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Minichromosome Maintenance Complex Component 71 2     P1CDC472
MCM21 2 3 5     P85MCM2
CDC472 3     PNAS1462
P1.1-MCM32 3     DNA Replication Licensing Factor MCM72
CDC47 Homolog2 3     Homolog Of S. Cerevisiae Cdc472
MCM7 Minichromosome Maintenance Deficient 7 (S. Cerevisiae)1     Minichromosome Maintenance Deficient 72
Minichromosome Maintenance Deficient (S. Cerevisiae) 71     EC 3.6.4.123

External Ids:    HGNC: 69501   Entrez Gene: 41762   Ensembl: ENSG000001665087   OMIM: 6005925   UniProtKB: P339933   

Export aliases for MCM7 gene to outside databases

Previous GC identifers: GC07M098224 GC07M099287 GC07M099301 GC07M099335 GC07M099528 GC07M094326


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MCM7 Gene:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that
are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the
MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of
replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of
this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme.
Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this
protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct
isoforms have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for MCM7 Gene: 
MCM7 (minichromosome maintenance complex component 7) is a protein-coding gene. Diseases associated with MCM7 include anus cancer, and follicular adenoma, and among its related super-pathways are Activation of the pre-replicative complex and Lagging Strand Synthesis. GO annotations related to this gene include ATP-dependent DNA helicase activity and single-stranded DNA binding.

UniProtKB/Swiss-Prot: MCM7_HUMAN, P33993
Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase
essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active
ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that
a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site
of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute
differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced
damage

Gene Wiki entry for MCM7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MCM7 gene promoter:
         C/EBPbeta   Elk-1   MyoD   Pax-4a   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): MCM7 promoter sequence
   Search SABiosciences Chromatin IP Primers for MCM7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCM7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.3-q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q21.3-q22.1

MCM7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCM7 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M099690:  view genomic region     (about GC identifiers)

Start:
99,690,351 bp from pter      End:
99,699,563 bp from pter
Size:
9,213 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 99,050,524-99,059,546     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MCM7_HUMAN, P33993 (See protein sequence)
Recommended Name: DNA replication licensing factor MCM7  
Size: 719 amino acids; 81308 Da
Subunit: Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit
order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (By simililarity). Interacts with the ATR-ATRIP complex and with RAD17.
Interacts with TIPIN. Interacts with MCMBP
Subcellular location: Nucleus (By similarity)
Miscellaneous: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and
tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in
vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological
active complex
Secondary accessions: A4D2A1 A4D2A2 E9PGN9 Q15076 Q96D34 Q96GL1
Alternative splicing: 3 isoforms:  P33993-1   P33993-2   P33993-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MCM7: NX_P33993

Explore proteomics data for MCM7 at MOPED 

Post-translational modifications:

  • UniProtKB: O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P33993

  • MCM7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MCM7 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001265524.1  NP_005907.3  NP_877577.1  

    ENSEMBL proteins: 
     ENSP00000344006   ENSP00000307288   ENSP00000445904   ENSP00000411295   ENSP00000346171  
    Reactome Protein details: P33993
    Human Recombinant Protein Products for MCM7: 
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    Novus Biologicals MCM7 Protein
    Novus Biologicals MCM7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MCM7 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin TAS8798650
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol IEA--
    GO:0042555MCM complex IMP15538388

    MCM7 for ontologies           About GeneDecksing



    MCM7 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MCM7
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    Novus Biologicals MCM7 Antibodies
    Abcam antibodies for MCM7
    Cloud-Clone Corp. Antibodies for MCM7 
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    LSBio Antibodies in human, mouse, rat for MCM7 

    Assay Products for MCM7: 
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    GenScript Custom Assay Services for MCM7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MCM7 
    Cloud-Clone Corp. CLIAs for MCM7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR008050 MCM7
     IPR018525 MCM_CS
     IPR012340 NA-bd_OB-fold
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry P33993

    ProtoNet protein and cluster: P33993

    2 Blocks protein domains:
    IPB001208 MCM family
    IPB008050 Mini-chromosome maintenance (MCM) protein 7 signature


    UniProtKB/Swiss-Prot: MCM7_HUMAN, P33993
    Similarity: Belongs to the MCM family
    Similarity: Contains 1 MCM domain


    MCM7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MCM7_HUMAN, P33993
    Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase
    essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active
    ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that
    a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site
    of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute
    differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced
    damage
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Genatlas biochemistry entry for MCM7:
    cell division cycle 47 (CDC47) homolog,early S-phase-like 7,participating in the cell cycle control of genome
    duplication

         Enzyme Number (IUBMB): EC 3.6.4.121

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003677contributes to DNA binding TAS15538388
    GO:0003678DNA helicase activity ----
    GO:0003697single-stranded DNA binding IEA--
    GO:0004003contributes to ATP-dependent DNA helicase activity IDA9305914
         
    MCM7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MCM7:
     Increased cell death HMECs cel 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mcm7):
     cellular  growth/size  hematopoietic system  mortality/aging 

    MCM7 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MCM7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MCM7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MCM7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MCM7 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MCM7:
    hsa-mir-1296 (MIRT000473)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCM7
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MCM7:
    hsa-miR-548p hsa-miR-1283
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): MCM7 (NM_182776)
    Sino Biological Human cDNA Clone for MCM7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCM7
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MCM7 About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Activation of the pre-replicative complex
    Activation of the pre-replicative complex0.67
    Cell cycle Start of DNA replication in early S phase0.54
    DNA Replication0.67
    2Lagging Strand Synthesis
    DNA strand elongation0.65
    Unwinding of DNA0.35
    DNA replication0.63
    3Mitotic G1-G1/S phases
    Mitotic G1-G1/S phases0.80
    G1 to S cell cycle control0.36
    G1/S Transition0.80
    4Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    5CDK-mediated phosphorylation and removal of Cdc6
    Assembly of the pre-replicative complex0.91
    DNA Replication Pre-Initiation0.81
    Removal of licensing factors from origins0.89
    Synthesis of DNA0.79
    Regulation of DNA replication0.89
    S Phase0.79
    Orc1 removal from chromatin0.89
    DNA Replication0.78

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for MCM7
        Meiosis
    Cell cycle Start of DNA replication in early S phase

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MCM7
        Cell Cycle Control of Chromosomal Replication

    1 Cell Signaling Technology (CST) Pathway for MCM7
        Cell Cycle / Checkpoint Control

    1 GeneGo (Thomson Reuters) Pathway for MCM7
        Cell cycle Start of DNA replication in early S phase

    4 BioSystems Pathways for MCM7
        Cell cycle
    G1 to S cell cycle control
    DNA Replication
    TNF-alpha/NF-kB Signaling Pathway


    5/21        Reactome Pathways for MCM7 (see all 21)
        Activation of ATR in response to replication stress
    Mitotic G1-G1/S phases
    DNA Replication
    Removal of licensing factors from origins
    Cell Cycle


    2         Kegg Pathways  (Kegg details for MCM7):
        DNA replication
    Cell cycle


    MCM7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MCM7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/214 Interacting proteins for MCM7 (P339931, 2, 3 ENSP000003072884) via UniProtKB, MINT, STRING, and/or I2D (see all 214)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=2 STRING: ENSP00000352980
    HIST1H4LP628053, ENSP000003482584I2D: score=2 STRING: ENSP00000348258
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006260DNA replication TAS--
    GO:0006268DNA unwinding involved in DNA replication IEA--
    GO:0006270DNA replication initiation IEA--

    MCM7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MCM7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MCM7

    1 HMDB Compound for MCM7    About this table
    CompoundSynonyms CAS #PubMed Ids
    AtorvastatinAtorvastatin acid (see all 4)134523-00-5--

    1 Novoseek inferred chemical compound relationship for MCM7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 0 1 9407133 (1)

    Search CenterWatch for drugs/clinical trials and news about MCM7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MCM7 gene (3 alternative transcripts): 
    NM_001278595.1  NM_005916.4  NM_182776.2  

    Unigene Cluster for MCM7:

    Minichromosome maintenance complex component 7
    Hs.438720  [show with all ESTs]
    Unigene Representative Sequence: NM_182776
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489841 ENST00000343023 ENST00000485286 ENST00000303887(uc003usw.1 uc003usx.1)
    ENST00000491245 ENST00000493352 ENST00000477372 ENST00000463722 ENST00000425308
    ENST00000467516 ENST00000465688 ENST00000465738 ENST00000354230(uc003usv.1)

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    Additional mRNA sequence: 

    AF279900.1 AK055379.1 AK096959.1 AK226175.1 AK293172.1 AK314575.1 AY007130.1 BC009398.2 
    BC013375.2 D55716.1 D86748.1 X74796.1 

    24/47 DOTS entries (see all 47):

    DT.100865596  DT.97822401  DT.75114430  DT.100059865  DT.40238956  DT.100670383  DT.100670394  DT.100670392 
    DT.100831807  DT.100670391  DT.97781385  DT.121080692  DT.100670385  DT.100756863  DT.100670388  DT.95121587 
    DT.95180726  DT.121080542  DT.100670389  DT.121080540  DT.121080640  DT.121080551  DT.121080676  DT.121080624 

    24/1154 AceView cDNA sequences (see all 1154):

    BE783431 BQ641811 BQ898941 BU146206 BC009398 BG164192 CF619256 CR594412 
    BU168432 BQ056049 BM824931 BU147232 AU126500 BM724036 BE393871 AI081155 
    CB121261 BE264432 BF796481 AA480023 BQ643247 BI333075 BE274836 BM914800 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for MCM7 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14 ^ 15 ^
    SP1:                          -     -                             -     -                             -                             -                           
    SP2:                          -     -                                                                 -                             -                           
    SP3:                                                                                                                                -                           
    SP4:                          -     -                                                                 -                             -                       -   
    SP5:                                                                                                  -                             -                           

    ExUns: 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b
    SP1:                    -                                       
    SP2:                    -                                       
    SP3:                    -                                       
    SP4:  -     -     -     -     -     -     -     -     -         
    SP5:                                                            


    ECgene alternative splicing isoforms for MCM7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MCM7 expression in normal human tissues (normalized intensities)      MCM7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCACTTAC
    MCM7 Expression
    About this image


    MCM7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/39 selected tissues (see all 39) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
             Human Cerebellar Astrocytes   
             brain/midbrain   
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             nasopharynx ; respiratory epithelial cells   
             sensory organ/nose/nasal cavity   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See MCM7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MCM7

    SOURCE GeneReport for Unigene cluster: Hs.438720
        SABiosciences Custom PCR Arrays for MCM7
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MCM7 gene from 9/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mcm71 , 5 minichromosome maintenance deficient 7 (S. cerevisiae)1, 5 86.93(n)1
    92.77(a)1
      5 (76.97 cM)5
    172201  NM_008568.21  NP_032594.11 
     1381645835 
    lizard
    (Anolis carolinensis)
    Reptilia MCM76
    Uncharacterized protein
    58(a)
    1 ↔ 1
    GL343882.1(5711-22504)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3978522 XMCM7 76.29(n)    U51234.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mcm72 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) 77.14(n)   192333  BC045497.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mcm71 , 3 pre-replicative complex formation and
    maintenance more3
    Minichromosome maintenance 71
    69(a)3
    63.7(n)1
    67.45(a)1
      66E33
    390141  NM_079260.21  NP_523984.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mcm-71 , 3 cell division control protein3
    Protein MCM-71
    56(a)3
    54.37(n)1
    52.1(a)1
      V(4347012-4349358)3
    1788311  NM_071798.41  NP_504199.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MCM7(YBR202W)4
    MCM71
    Component of the heterohexameric MCM2-7 complex, which more4
    Mcm7p1
    51.25(n)1
    50.07(a)1
      2(625772-628309)4
    8525011, 4  NP_009761.41  NP_009761.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PRL1 protein PROLIFERA 53.01(n)
    51.49(a)
      828153  NM_001203726.1  NP_001190655.1 
    rice
    (Oryza sativa)
    Liliopsida Os.249512 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 76.24(n)    AK073411.1 


    ENSEMBL Gene Tree for MCM7 (if available)
    TreeFam Gene Tree for MCM7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MCM7 gene
    7 SIMAP similar genes for MCM7 using alignment to 3 protein entries:     MCM7_HUMAN (see all proteins):
    MCM6    MCM4    MCM9    MCM5    MCM3    MCM2
    HCC5

    MCM7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/176 SNPs in MCM7 are shown (see all 176)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0148174
    ----see VAR_0148172 G S mis40--------
    rs1871605631,2
    --99690377(+) TTTTAA/GTGGAA 2 -- ds50010--------
    rs2019704011,2
    --99690576(+) CGTGTC/GCGGGA 4 R syn10--------
    rs150151,2
    C,H--99690599(-) TCAATG/TTCTGG 4 V F mis1 ese37Minor allele frequency- T:0.00MN NS EA NA 594
    rs1407765611,2
    C,F--99693714(+) GTCAGT/CTCTCC 4 /E syn11Minor allele frequency- C:0.00NA 4544
    rs1501027891,2
    C,F--99693725(+) ACTCAC/G/TGGAGT 6 M L V mis11NA 4524
    rs1388987951,2
    F--99693726(+) CTCACG/AGAGTC 4 /S syn11Minor allele frequency- A:0.00NA 4522
    rs617499091,2
    C,F--99693747(+) GCTGCC/TGTAAG 4 T syn12Minor allele frequency- T:0.01NA EU 5521
    rs1387106091,2
    C--99693818(+) CCATGA/GGAGAG 2 -- int11Minor allele frequency- G:0.00EU 1117
    rs746949341,2
    F--99693943(+) GGGGCA/GCTGGC 2 -- int11Minor allele frequency- G:0.05WA 118

    HapMap Linkage Disequilibrium report for MCM7 (99690351 - 99699563 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MCM7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    nsv469687CNV Loss16826518
    nsv510966CNV Complex20534489

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600592    OMIM disorders: --

    20/45 diseases for MCM7 (see all 45):    About MalaCards
    anus cancer    follicular adenoma    adenocarcinoma in situ    myxofibrosarcoma
    pancreatic ductal carcinoma    benign meningioma    merkel cell carcinoma    cervical adenocarcinoma
    oligodendroglioma    synovial sarcoma    prostate cancer, progression of    malignant mesothelioma
    meningioma    retinoblastoma    osteosarcoma    diffuse large b-cell lymphoma
    b-cell lymphomas    oral squamous cell carcinoma    adenocarcinoma    prostate cancer

    1 disease from the University of Copenhagen DISEASES database for MCM7:
    Carcinoma

    MCM7 for disorders           About GeneDecksing

    10/16 Novoseek inferred disease relationships for MCM7 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 53.9 4 12642231 (1), 9566894 (1), 12677008 (1), 16179903 (1)
    adenoma follicular 41.4 2 16722928 (2)
    oligodendroglioma 35.4 3 11532161 (2), 15199392 (1)
    cancer 31.9 3 20388916 (1), 14678972 (1), 20136698 (1)
    aggressiveness 28.3 1 17094475 (1)
    tumors 27.2 30 15668898 (3), 18636144 (3), 11861392 (2), 16247466 (2) (see all 11)
    adenocarcinoma 26.6 2 18474544 (1), 15452160 (1)
    dysplasia 9.58 1 20136698 (1)
    osteosarcoma 7.78 2 11056214 (1)
    prostate cancer 2.96 9 16247466 (4), 15452160 (2)

    Genetic Association Database (GAD): MCM7
    Human Genome Epidemiology (HuGE) Navigator: MCM7 (2 documents)

    Export disorders for MCM7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MCM7 gene, integrated from 9 sources (see all 226):
    (articles sorted by number of sources associating them with MCM7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication. (PubMed id 7842741)1, 2, 3 Nakatsuru S.... Nakamura Y. (1995)
    2. Identification and characterization of a novel component of the human minichromosome maintenance complex. (PubMed id 17296731)1, 2, 9 Sakwe A.M....Frappier L. (2007)
    3. Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. (PubMed id 15210935)1, 2, 9 Cortez D.... Elledge S.J. (2004)
    4. Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. (PubMed id 15538388)1, 2, 9 Tsao C.-C.... Abraham R.T. (2004)
    5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    6. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PubMed id 19401682)1, 4 Maestrini E....Monaco A.P. (2009)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    10. A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex. (PubMed id 9305914)1, 2 Ishimi Y. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4176 HGNC: 6950 AceView: MCM7 Ensembl:ENSG00000166508 euGenes: HUgn4176
    ECgene: MCM7 Kegg: 4176 H-InvDB: MCM7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MCM7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MCM7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MCM7 gene:
    Search GeneIP for patents involving MCM7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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