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Aliases for MCM7 Gene

Aliases for MCM7 Gene

  • Minichromosome Maintenance Complex Component 7 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 104 2 3
  • CDC47 Homolog 3 4
  • P1.1-MCM3 3 4
  • CDC47 3 4
  • MCM2 3 4
  • MCM7 Minichromosome Maintenance Deficient 7 (S. Cerevisiae) 2
  • Minichromosome Maintenance Deficient (S. Cerevisiae) 7 2
  • Minichromosome Maintenance Deficient 7 3
  • DNA Replication Licensing Factor MCM7 3
  • Homolog Of S. Cerevisiae Cdc47 3
  • EC 3.6.4.12 4
  • PPP1R104 3
  • P1CDC47 3
  • PNAS146 3
  • P85MCM 3

External Ids for MCM7 Gene

Previous HGNC Symbols for MCM7 Gene

  • MCM2

Previous GeneCards Identifiers for MCM7 Gene

  • GC07M098224
  • GC07M099287
  • GC07M099301
  • GC07M099335
  • GC07M099528
  • GC07M099690
  • GC07M094326

Summaries for MCM7 Gene

Entrez Gene Summary for MCM7 Gene

  • The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for MCM7 Gene

MCM7 (Minichromosome Maintenance Complex Component 7) is a Protein Coding gene. Diseases associated with MCM7 include Cervix Endometriosis and Melanoacanthoma. Among its related pathways are E2F mediated regulation of DNA replication and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include ATPase activity and ATP-dependent DNA helicase activity.

UniProtKB/Swiss-Prot for MCM7 Gene

  • Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.

Gene Wiki entry for MCM7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCM7 Gene

Genomics for MCM7 Gene

Regulatory Elements for MCM7 Gene

Enhancers for MCM7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G100076 1.2 ENCODE 12.4 +21.8 21837 6.7 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D SSRP1 AP4M1 ZSCAN25 ZNF655 SMURF1 MBLAC1 PPP1R35 ZSCAN21 GIGYF1 STAG3L5P ENSG00000242798
GH07G100124 1.1 ENCODE 12.1 -24.7 -24734 4.6 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 YY1 ZNF766 MBLAC1 MCM7 AP4M1 PVRIG AGFG2 PILRA CNPY4 COPS6 LOC100131859 TAF6
GH07G100040 1.1 ENCODE dbSUPER 11 +60.2 60243 1.6 BCOR CTCF PKNOX1 ESRRA FOXA2 TAL1 JUN ZNF644 THRB RAD21 AP4M1 ZSCAN21 ZKSCAN1 COPS6 MIR106B MIR25 MIR93 MCM7 PILRA GC07P100039
GH07G100141 0.9 Ensembl ENCODE 11.2 -40.0 -39978 1.4 ESRRA HLF USF2 ZMYM3 CEBPB MAX ATF2 NFIL3 ZNF121 CEBPA AP4M1 TAF6 GAL3ST4 GPC2 STAG3 CNPY4 PVRIG GATS MCM7 RPL7P60
GH07G100061 0.8 ENCODE 11.9 +40.1 40112 0.8 BCOR HDGF PKNOX1 CBX3 ARNT TAL1 TCF12 FOXM1 POLR2A GATA2 COPS6 MIR106B MIR25 MIR93 MCM7 ZKSCAN1 TRIM4 PIR44616 GC07M100084 PIR43713
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MCM7 on UCSC Golden Path with GeneCards custom track

Promoters for MCM7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215738 740 2401 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21

Genomic Location for MCM7 Gene

Chromosome:
7
Start:
100,092,728 bp from pter
End:
100,101,940 bp from pter
Size:
9,213 bases
Orientation:
Minus strand

Genomic View for MCM7 Gene

Genes around MCM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCM7 Gene

Proteins for MCM7 Gene

  • Protein details for MCM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33993-MCM7_HUMAN
    Recommended name:
    DNA replication licensing factor MCM7
    Protein Accession:
    P33993
    Secondary Accessions:
    • A4D2A1
    • A4D2A2
    • E9PGN9
    • Q15076
    • Q96D34
    • Q96GL1

    Protein attributes for MCM7 Gene

    Size:
    719 amino acids
    Molecular mass:
    81308 Da
    Quaternary structure:
    • Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (Probable). Interacts with the ATR-ATRIP complex and with RAD17. Interacts with TIPIN. Interacts with MCMBP. Interacts with ANKRD17.
    Miscellaneous:
    • Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.

    Alternative splice isoforms for MCM7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCM7 Gene

Post-translational modifications for MCM7 Gene

  • O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
  • Ubiquitination at posLast=1515, posLast=2828, Lys32, Lys75, posLast=8989, posLast=9696, posLast=145145, Lys231, Lys236, posLast=308308, Lys335, Lys387, posLast=471471, posLast=557557, Lys569, posLast=596596, Lys627, Lys641, and posLast=648648
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MCM7 Gene

Domains & Families for MCM7 Gene

Suggested Antigen Peptide Sequences for MCM7 Gene

Graphical View of Domain Structure for InterPro Entry

P33993

UniProtKB/Swiss-Prot:

MCM7_HUMAN :
  • Belongs to the MCM family.
Family:
  • Belongs to the MCM family.
genes like me logo Genes that share domains with MCM7: view

Function for MCM7 Gene

Molecular function for MCM7 Gene

GENATLAS Biochemistry:
cell division cycle 47 (CDC47) homolog,early S-phase-like 7,participating in the cell cycle control of genome duplication
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.

Enzyme Numbers (IUBMB) for MCM7 Gene

Gene Ontology (GO) - Molecular Function for MCM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003677 contributes_to DNA binding TAS 15538388
GO:0003678 DNA helicase activity IEA --
GO:0003697 single-stranded DNA binding IEA --
GO:0004003 contributes_to ATP-dependent DNA helicase activity IDA 9305914
genes like me logo Genes that share ontologies with MCM7: view
genes like me logo Genes that share phenotypes with MCM7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCM7 Gene

Localization for MCM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCM7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCM7 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MCM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region IDA 19135898
GO:0000785 chromatin TAS 8798650
GO:0005634 nucleus IDA,IEA 21383955
GO:0005654 nucleoplasm TAS --
GO:0005730 NOT nucleolus IDA 21383955
genes like me logo Genes that share ontologies with MCM7: view

Pathways & Interactions for MCM7 Gene

genes like me logo Genes that share pathways with MCM7: view

Pathways by source for MCM7 Gene

SIGNOR curated interactions for MCM7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MCM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0006260 DNA replication TAS --
GO:0006268 DNA unwinding involved in DNA replication IEA --
GO:0006270 DNA replication initiation IEA --
GO:0006974 cellular response to DNA damage stimulus IMP 15538388
genes like me logo Genes that share ontologies with MCM7: view

Drugs & Compounds for MCM7 Gene

(5) Drugs for MCM7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
atorvastatin Approved Pharma Competitive, Inhibitor 0
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for MCM7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MCM7: view

Transcripts for MCM7 Gene

Unigene Clusters for MCM7 Gene

Minichromosome maintenance complex component 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCM7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14 ^ 15 ^
SP1: - - - - - -
SP2: - - - -
SP3: -
SP4: - - - - -
SP5: - -
SP6: - - - - -
SP7: -
SP8: -
SP9: - - - - -
SP10: - -
SP11: -
SP12: - - - - - - - - - - - - - - -
SP13:
SP14:

ExUns: 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b
SP1: -
SP2: -
SP3: -
SP4: - - - - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - -
SP13:
SP14:

Relevant External Links for MCM7 Gene

GeneLoc Exon Structure for
MCM7
ECgene alternative splicing isoforms for
MCM7

Expression for MCM7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MCM7 Gene

Protein differential expression in normal tissues from HIPED for MCM7 Gene

This gene is overexpressed in Liver (15.2), Lymph node (14.3), and Fetal ovary (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MCM7 Gene



Protein tissue co-expression partners for MCM7 Gene

NURSA nuclear receptor signaling pathways regulating expression of MCM7 Gene:

MCM7

SOURCE GeneReport for Unigene cluster for MCM7 Gene:

Hs.438720

Evidence on tissue expression from TISSUES for MCM7 Gene

  • Nervous system(5)
  • Lung(4.8)
  • Skin(4.5)
  • Intestine(4.2)
  • Blood(4.1)
  • Kidney(3.8)
  • Liver(3.6)
  • Eye(3.5)
  • Muscle(3.5)
  • Lymph node(2.6)
  • Stomach(2.2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with MCM7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCM7 Gene

Orthologs for MCM7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCM7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCM7 35 34
  • 99.4 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCM7 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MCM7 34 35
  • 89.34 (n)
dog
(Canis familiaris)
Mammalia MCM7 35 34
  • 88.73 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcm7 34
  • 87.07 (n)
mouse
(Mus musculus)
Mammalia Mcm7 34 16 35
  • 86.93 (n)
lizard
(Anolis carolinensis)
Reptilia MCM7 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mcm7 34
  • 74.12 (n)
Str.6411 34
African clawed frog
(Xenopus laevis)
Amphibia LOC397852 34
zebrafish
(Danio rerio)
Actinopterygii mcm7 34 35
  • 73.57 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9124 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005800 34
  • 64.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mcm7 36 34 35
  • 63.7 (n)
worm
(Caenorhabditis elegans)
Secernentea mcm-7 36 34 35
  • 54.57 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR041W 34
  • 54.01 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E23189g 34
  • 52.07 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCM7 35 37 34
  • 51.25 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons PRL 34
  • 53.7 (n)
soybean
(Glycine max)
eudicotyledons Gma.10482 34
rice
(Oryza sativa)
Liliopsida Os12g0560700 34
  • 53.13 (n)
Os.24951 34
wheat
(Triticum aestivum)
Liliopsida Ta.7561 34
corn
(Zea mays)
Liliopsida Zm.3812 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8017 35
  • 69 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU08119 34
  • 56.38 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mcm7 34
  • 51.66 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4257 34
Species where no ortholog for MCM7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MCM7 Gene

ENSEMBL:
Gene Tree for MCM7 (if available)
TreeFam:
Gene Tree for MCM7 (if available)

Paralogs for MCM7 Gene

(7) SIMAP similar genes for MCM7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MCM7: view

No data available for Paralogs for MCM7 Gene

Variants for MCM7 Gene

Sequence variations from dbSNP and Humsavar for MCM7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs752598529 Pathogenic 100,102,939(+) GTATA(C/G)GAACT intron-variant, upstream-variant-2KB, reference, stop-gained, utr-variant-5-prime
rs797045249 Likely pathogenic 100,101,746(+) CTCCA(-/A)GGGGG upstream-variant-2KB, reference, frameshift-variant, utr-variant-5-prime
rs41280965 Likely benign 100,102,755(+) TCTCC(C/T)TTCAG intron-variant, upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs138437966 Uncertain significance 100,102,942(+) TACGA(A/C)CTCCT intron-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs367614875 Uncertain significance 100,102,716(+) AGCGG(C/T)CTCTA intron-variant, upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MCM7 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv469687 CNV loss 16826518
nsv510966 OTHER complex 20534489
nsv607931 CNV loss 21841781
nsv951384 CNV deletion 24416366

Variation tolerance for MCM7 Gene

Residual Variation Intolerance Score: 9.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.40; 81.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCM7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCM7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCM7 Gene

Disorders for MCM7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MCM7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cervix endometriosis
  • cervical endometriosis
melanoacanthoma
- elite association - COSMIC cancer census association via MalaCards
Search MCM7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MCM7

Genetic Association Database (GAD)
MCM7
Human Genome Epidemiology (HuGE) Navigator
MCM7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCM7
genes like me logo Genes that share disorders with MCM7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MCM7 Gene

Publications for MCM7 Gene

  1. Identification and characterization of a novel component of the human minichromosome maintenance complex. (PMID: 17296731) Sakwe A.M. … Frappier L. (Mol. Cell. Biol. 2007) 3 4 22 64
  2. Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. (PMID: 15210935) Cortez D. … Elledge S.J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 22 64
  3. Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. (PMID: 15538388) Tsao C.-C. … Abraham R.T. (EMBO J. 2004) 3 4 22 64
  4. Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication. (PMID: 7842741) Nakatsuru S. … Nakamura Y. (Cytogenet. Cell Genet. 1995) 2 3 4 64
  5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64

Products for MCM7 Gene

  • Addgene plasmids for MCM7

Sources for MCM7 Gene

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