Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MCM7 Gene

protein-coding GIFtS: 69
GCID: GC07M099690

minichromosome maintenance complex component 7

(Previous names: minichromosome maintenance deficient (S. cerevisiae) 7,...)
(Previous symbol: MCM2)

Explore 47 diseases affiliated with
MCM7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Minichromosome Maintenance Complex Component 7¹ ²		P1CDC47²
MCM2¹ ² ³ ⁵		P85MCM²
CDC47¹ ² ³		PNAS146²
P1.1-MCM3² ³		DNA Replication Licensing Factor MCM7²
CDC47 Homolog² ³		Homolog Of S. Cerevisiae Cdc47²
MCM7 Minichromosome Maintenance Deficient 7 (S. Cerevisiae)¹		Minichromosome Maintenance Deficient 7²
Minichromosome Maintenance Deficient (S. Cerevisiae) 7¹		EC 3.6.4.12³

External Ids:	HGNC: 6950¹	Entrez Gene: 4176²	Ensembl: ENSG00000166508⁷	OMIM: 600592⁵	UniProtKB: P33993³

Export aliases for MCM7 gene to outside databases

Previous GC identifers: GC07M098224 GC07M099287 GC07M099301 GC07M099335 GC07M099528 GC07M094326

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MCM7:

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are

essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM

proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of

replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this

protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin

D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with

the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been

reported. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MCM7_HUMAN, P33993

Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential

for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in

the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure

of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the

adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex

helicase activity. Required for S-phase checkpoint activation upon UV-induced damage

Gene Wiki entry for MCM7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MCM7 gene promoter:
C/EBPbeta Elk-1 MyoD Pax-4a Tal-1beta E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): MCM7 promoter sequence

Search SABiosciences Chromatin IP Primers for MCM7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCM7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.3-q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q21.3-q22.1

MCM7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCM7 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M099690: view genomic region (about GC identifiers)

Start:	99,690,351 bp from pter	End:	99,699,563 bp from pter
Size:	9,213 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 99,050,524-99,059,546

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MCM7_HUMAN, P33993 (See protein sequence)

Recommended Name: DNA replication licensing factor MCM7

Size: 719 amino acids; 81308 Da

Subunit: Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order

MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (By simililarity). Interacts with the ATR-ATRIP complex and with RAD17. Interacts with

TIPIN. Interacts with MCMBP

Subcellular location: Nucleus (By similarity)

Miscellaneous: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric

complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase

activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex

Secondary accessions: A4D2A1 A4D2A2 E9PGN9 Q15076 Q96D34 Q96GL1

Alternative splicing: 3 isoforms: P33993-1 P33993-2 P33993-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MCM7: NX_P33993

Post-translational modifications:

O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P33993

MCM7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_005907.3 NP_877577.1

ENSEMBL proteins:

ENSP00000344006 ENSP00000307288 ENSP00000445904 ENSP00000411295 ENSP00000346171

Reactome Protein details: P33993
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: MCM7 OriGene Protein Over-expression Lysate: MCM7 OriGene Custom Protein Services for MCM7
	GenScript Custom Purified and Recombinant Proteins Services for MCM7
	Novus Biologicals MCM7 Protein Novus Biologicals MCM7 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MCM7

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000785	chromatin	TAS	8798650
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	TAS	--
GO:0005829	cytosol	IEA	--
GO:0042555	MCM complex	IMP	15538388

MCM7 for ontologies About GeneDecksing

MCM7 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MCM7
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for MCM7
	OriGene Antibodies (see all 4): MCM7 OriGene Custom Antibody Services for MCM7
	GenScript Custom Superior Antibodies Services for MCM7
	Novus Biologicals MCM7 Antibodies
	Abcam antibodies for MCM7
	Uscn Antibodies for MCM7
	ThermoFisher Antibody for MCM7

Assay Products for MCM7:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MCM7
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MCM7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MCM7 for domains About GeneDecksing

5 InterPro domains/families:

IPR008050 MCM7

IPR018525 MCM_CS

IPR012340 NA-bd_OB-fold

IPR003593 AAA+_ATPase

IPR001208 MCM_DNA-dep_ATPase

Graphical View of Domain Structure for InterPro Entry P33993

ProtoNet protein and cluster: P33993

2 Blocks protein families:

IPB001208 MCM family

IPB008050 Mini-chromosome maintenance (MCM) protein 7 signature

UniProtKB/Swiss-Prot: MCM7_HUMAN, P33993

Similarity: Belongs to the MCM family

Similarity: Contains 1 MCM domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MCM7_HUMAN, P33993

Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential

for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in

the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure

of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the

adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex

helicase activity. Required for S-phase checkpoint activation upon UV-induced damage

Catalytic activity: ATP + H(2)O = ADP + phosphate

Genatlas biochemistry entry for MCM7:

cell division cycle 47 (CDC47) homolog,early S-phase-like 7,participating in the cell cycle control of genome

duplication

Enzyme Number (IUBMB): EC 3.6.4.12¹

miRNA Products:		miRTarBase miRNAs that target MCM7: hsa-mir-1296 (MIRT000473)

		OriGene 3'-UTR Clone (see all 2): MCM7 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCM7
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate MCM7:
		hsa-miR-548p hsa-miR-1283
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCM7 (see all 7) OriGene shRNA RFP: MCM7 OriGene siRNA: MCM7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MCM7

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MCM7

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCM7 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCM7 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MCM7 (NM_182776)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCM7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCM7

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MCM7
		Search LifeMap BioReagents cell lines for MCM7

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM7

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	contributes to DNA binding	TAS	15538388
GO:0003678	DNA helicase activity	--	--
GO:0003697	single-stranded DNA binding	IEA	--
GO:0004003	contributes to ATP-dependent DNA helicase activity	IDA	9305914
GO:0005515	protein binding	IPI	17314511

MCM7 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MCM7:

Increased cell death HMECs cel

Animal Models:
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mcm7):

cellular

growth/size

hematopoietic system

mortality/aging

MCM7 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/11 pathways (see all 11)
Assembly of the pre-replicative complex	0.77	M/G1 Transition	0.62
Switching of origins to a post-replicative state	0.70	Synthesis of DNA	0.51
Orc1 removal from chromatin	0.70	DNA Replication	0.49
Regulation of DNA replication	0.68	Cell Cycle Checkpoints	0.42

Cell cycle

	Cell cycle	1.00			G1 to S cell cycle control	0.38
	Cell cycle	0.57

Lagging Strand Synthesis

	DNA strand elongation	0.65			Unwinding of DNA	0.00
	DNA replication	0.56

Cell cycle_Start of DNA replication in early S phase

Cell cycle_Start of DNA replication in early S phase

1.00

Cell cycle Start of DNA replication in early S phase

0.98

Activation of ATR in response to replication stress

Activation of ATR in response to replication stress

1.00

G2/M Checkpoints

0.86

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for MCM7

	Meiosis
	Cell cycle Start of DNA replication in early S phase

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MCM7

Cell Cycle Control of Chromosomal Replication

1 Cell Signaling Technology (CST) Pathway for MCM7

Cell Cycle / Checkpoint Control

1 GeneGo (Thomson Reuters) Pathway for MCM7

Cell cycle Start of DNA replication in early S phase

4 BioSystems Pathways for MCM7

	G1 to S cell cycle control
	Cell cycle
	TNF-alpha/NF-kB Signaling Pathway
	DNA Replication

5/21 Reactome Pathways for MCM7 (see all 21)

	Activation of ATR in response to replication stress
	Mitotic G1-G1/S phases
	DNA Replication
	Removal of licensing factors from origins
	Cell Cycle

2 Kegg Pathways (Kegg details for MCM7):

	DNA replication
	Cell cycle

MCM7 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MCM7

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/205 Interacting proteins for MCM7 (P33993^{1, 2, 3} ENSP00000307288⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 205)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³, ENSP00000352980⁴	I2D: score=2 STRING: ENSP00000352980
HIST1H4L	P62805³, ENSP00000348258⁴	I2D: score=2 STRING: ENSP00000348258
HIST1H4B	P62805³	I2D: score=2
HIST1H4C	P62805³	I2D: score=2
HIST1H4D	P62805³	I2D: score=2

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000084	S phase of mitotic cell cycle	TAS	--
GO:0000216	M/G1 transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--

MCM7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MCM7 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MCM7

1 HMDB Compound for MCM7 About this table

Compound	Synonyms	CAS #	PubMed Ids
Atorvastatin	Atorvastatin acid (see all 4)	134523-00-5	--

1 Novoseek chemical compound relationship for MCM7 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	0	1	9407133 (1)

Search CenterWatch for drugs/clinical trials and news about MCM7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MCM7 gene (2 alternative transcripts):

NM_005916.3 NM_182776.1

Unigene Cluster for MCM7:

Minichromosome maintenance complex component 7

Hs.438720 [show with all ESTs]

Unigene Representative Sequence: NM_182776

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000489841 ENST00000343023 ENST00000485286 ENST00000303887(uc003usw.1 uc003usx.1)

ENST00000491245 ENST00000493352 ENST00000477372 ENST00000463722 ENST00000425308

ENST00000467516 ENST00000465688 ENST00000465738 ENST00000354230(uc003usv.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MCM7 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCM7
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate MCM7:
		hsa-miR-548p hsa-miR-1283
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCM7 (see all 7) OriGene shRNA RFP: MCM7 OriGene siRNA: MCM7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MCM7

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCM7 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCM7 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MCM7 (NM_182776)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCM7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCM7

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MCM7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MCM7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCM7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCM7

Additional cDNA sequence:

AF279900.1 AK055379.1 AK096959.1 AK226175.1 AK293172.1 AK314575.1 AY007130.1 BC009398.2

BC013375.2 D55716.1 D86748.1 X74796.1

24/47 DOTS entries (see all 47):

DT.100865596 DT.97822401 DT.75114430 DT.100059865 DT.40238956 DT.100670383 DT.100670394 DT.100670392

DT.100831807 DT.100670391 DT.97781385 DT.121080692 DT.100670385 DT.100756863 DT.100670388 DT.95121587

DT.95180726 DT.121080542 DT.100670389 DT.121080540 DT.121080640 DT.121080551 DT.121080676 DT.121080624

24/1154 AceView cDNA sequences (see all 1154):

CF541208 BQ056414 AK096959 BG386746 BE312653 BU165222 AU129974 BE791786

AW410794 AU125932 BE264432 BM826650 AW104763 AA312840 BQ670399 BE392251

CR608168 AU131038 CK430660 BE270305 BM916932 CR611015 AU130924 AI492633

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for MCM7 (see all 14) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12a	·	12b	·	12c	·	12d	^	13a	·	13b	^	14	^	15	^
SP1:									-		-										-		-										-										-
SP2:									-		-																						-										-
SP3:																																											-
SP4:									-		-																						-										-								-
SP5:																																	-										-

ExUns:	16	^	17a	·	17b	^	18a	·	18b	^	19	^	20a	·	20b	^	21a	·	21b
SP1:							-
SP2:							-
SP3:							-
SP4:	-		-		-		-		-		-		-		-		-
SP5:

ECgene alternative splicing isoforms for MCM7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MCM7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCACTTAC

About this image

MCM7 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Metanephric Mesenchyme

Metanephric Mesenchyme Cells

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

ES04(HES-4) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See MCM7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MCM7

SOURCE GeneReport for Unigene cluster: Hs.438720

SABiosciences Custom PCR Arrays for MCM7

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MCM7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MCM7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCM7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCM7

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCM7 gene from 8/38 species (see all 38) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	MCM7⁶	--	56(a)	1 ↔ 1	GL343882.1(5845-22504)
African clawed frog (Xenopus laevis)	Amphibia	LOC397852²	XMCM7	76.29(n)		U51234.1
zebrafish (Danio rerio)	Actinopterygii	mcm7²	MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)	77.14(n)		192333 BC045497.1
fruit fly (Drosophila melanogaster)	Insecta	Mcm7^{1 , 3}	pre-replicative complex formation and maintenance more³ Minichromosome maintenance 7¹	69(a)³ 63.7(n)¹ 67.45(a)¹		66E3³ 39014¹ NM_079260.2¹ NP_523984.1¹
worm (Caenorhabditis elegans)	Secernentea	mcm-7^{1 , 3}	cell division control protein³ Protein MCM-7¹	56(a)³ 54.37(n)¹ 52.1(a)¹		V(4347012-4349358)³ 178831¹ NM_071798.4¹ NP_504199.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	MCM7(YBR202W)⁴ MCM7¹	Component of the heterohexameric MCM2-7 complex, which more⁴ Mcm7p¹	51.25(n)¹ 50.07(a)¹		2(625772-628309)⁴ 852501^{1, 4} NP_009761.4¹ NP_009761.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	PRL¹	protein PROLIFERA	53.01(n) 51.49(a)		828153 NM_001203726.1 NP_001190655.1
rice (Oryza sativa)	Liliopsida	Os.24951²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	76.24(n)		AK073411.1

ENSEMBL Gene Tree for MCM7 (if available)
TreeFam Gene Tree for MCM7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111431178^1,2	F	--	99057297(+)	`GCCTCG/ACCCTT`	1	--	us2k¹		2		CSA	4
rs112216147^1,2	F	--	99057788(+)	`CTTCCT/CGAGTT`	1	--	us2k¹		2		CSA	7
rs73159721^1,2		--	99058035(+)	`CAGTGA/CACAGG`	1	--	us2k¹		0	--	--	--	--
rs7778182^1,2	C,A	--	99058070(+)	`ATTCCA/GGTCCC`	1	--	us2k¹		0	--	--	--	--
rs4319008^1,2	C,F,A,H,	--	99058134(+)	`CTCAAG/AGTTCT`	1	--	us2k¹		22		MN NS EA NA	2846
rs78828105^1,2	C,	--	99058618(+)	`GCGCGC/GCTGGG`	1	--	us2k¹		2		CSA WA	119
rs76000357^1,2	C,F,	--	99058909(+)	`GAACCC/GGCCGA`	1	--	us2k¹		1		WA	118
rs11552037^1,2	C	--	99059053(-)	`GGCCGC/TACGGC`	1	--	us2k¹ ese³		2		NA	4
rs112138078^1,2	F	--	99059397(+)	`TCCGGA/GGCCGC`	1	--	ut5¹		2		CSA	5
rs3757452^1,2	C,	--	99060283(+)	`CAGGCA/GTATGT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MCM7 (99690351 - 99699563 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MCM7
1 CNV: 2104

SABiosciences Cancer Mutation PCR Assays

1 SABiosciences qBiomarker Copy Number PCR Array containing MCM7:

Prostate Cancer

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MCM7

DNA2.0 Custom Variant and Variant Library Synthesis for MCM7

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MCM7 for disorders           About GeneDecksing

OMIM gene information: 600592    OMIM disorders: --

20/47 diseases for MCM7 (see all 47):    About MalaCards

diffuse large b-cell lymphoma b-cell lymphomas oral squamous cell carcinoma merkel cell carcinoma

squamous cell carcinoma synovial sarcoma benign meningioma anus cancer

pancreatic ductal carcinoma malignant mesothelioma follicular adenoma oligodendroglioma

renal cell carcinoma carcinoma prostate cancer prostate cancer, progression of

adenocarcinoma adenoma adenocarcinoma in situ retinoblastoma

1 disease from the University of Copenhagen DISEASES database for MCM7:

Carcinoma

10/16 Novoseek disease relationships for MCM7 gene (see all 16) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	53.9	4	12642231 (1), 9566894 (1), 12677008 (1), 16179903 (1)
adenoma follicular	41.4	2	16722928 (2)
oligodendroglioma	35.4	3	11532161 (2), 15199392 (1)
cancer	31.9	3	20388916 (1), 14678972 (1), 20136698 (1)
aggressiveness	28.3	1	17094475 (1)
tumors	27.2	30	15668898 (3), 18636144 (3), 11861392 (2), 16247466 (2) (see all 11)
adenocarcinoma	26.6	2	18474544 (1), 15452160 (1)
dysplasia	9.58	1	20136698 (1)
osteosarcoma	7.78	2	11056214 (1)
prostate cancer	2.96	9	16247466 (4), 15452160 (2)

Human Genome Epidemiology (HuGE) Navigator: MCM7 (2 documents)

Export disorders for MCM7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MCM7 gene, integrated from 9 sources (see all 210):
(articles sorted by number of sources associating them with MCM7)

Utopia: connect your pdf to the dynamic
world of online information

Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication. (PubMed id 7842741)^{1, 2, 3} Nakatsuru S.... Nakamura Y. (1995)
Identification and characterization of a novel component of the human minichromosome maintenance complex. (PubMed id 17296731)^{1, 2, 9} Sakwe A.M....Frappier L. (2007)
Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. (PubMed id 15210935)^{1, 2, 9} Cortez D.... Elledge S.J. (2004)
Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. (PubMed id 15538388)^{1, 2, 9} Tsao C.-C.... Abraham R.T. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (2003)
A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex. (PubMed id 9305914)^{1, 2} Ishimi Y. (1997)
hCDC47, a human member of the MCM family. Dissociation of the nucleus-bound form during S phase. (PubMed id 8626784)^{1, 2} Fujita M.... Ishibashi M. (1996)
The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins. (PubMed id 8265339)^{1, 2} Hu B.... Knippers R. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4176	HGNC: 6950	AceView: MCM7	Ensembl:ENSG00000166508	euGenes: HUgn4176
ECgene: MCM7	Kegg: 4176	H-InvDB: MCM7

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MCM7	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MCM7	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MCM7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MCM7 gene:
Search GeneIP for patents involving MCM7

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Kits and Assays available from EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of MCM7
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for MCM7		OriGene shRNA RFP for MCM7
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCM7		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MCM7
	OriGene Protein Over-expression Lysate for MCM7		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for MCM7		OriGene 3'-UTR Clone for MCM7
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCM7		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCM7
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for MCM7		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MCM7		OriGene Custom Protein Services for MCM7
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MCM7
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MCM7
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCM7
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MCM7
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCM7
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCM7

	GenScript Custom Purified and Recombinant Proteins Services for MCM7		GenScript cDNA clones with any tag delivered in your preferred vector for MCM7
	GenScript Custom Assay Services for MCM7		GenScript Custom Superior Antibodies Services for MCM7
	GenScript Custom overexpressing Cell Line Services for MCM7		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for MCM7

	Regulatory tfbs in MCM7 promoter
	Search Chromatin IP Primers for MCM7
	RT² qPCR Primer Assay in human, mouse, rat MCM7
	GNC Network for MCM7
	SABiosciences PCR Arrays including human, mouse, rat MCM7

Search Tocris compounds for MCM7

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	MCM7 antibodies
	MCM7 proteins
	MCM7 lysates

	Antibodies for MCM7
	See all of Abcam's Antibodies, Kits and Proteins for MCM7
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

MCM7 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for MCM7

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM7

	Browse SwitchGear 3'UTR luciferase reporter plasmids for MCM7
	SwitchGear Promoter luciferase reporter plasmids for MCM7

ThermoFisher Antibody for MCM7

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCM7

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MCM7 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

MCM7 Gene

minichromosome maintenance complex component 7

Aliases
for MCM7 gene

Summaries
for MCM7 gene

Genomic Views
for MCM7 gene

Proteins
for MCM7 gene

Protein Domains /
Families
for MCM7 gene

Function
for MCM7 gene

Pathways & Interactions
for MCM7 gene

Drugs & Compounds
for MCM7 gene

Transcripts
for MCM7 gene

Expression
for MCM7 gene

Orthologs
for MCM7 gene

Paralogs
for MCM7 gene

Genomic Variants
for MCM7 gene

Disorders / Diseases
for MCM7 gene

Publications
for MCM7 gene

External Searches for MCM7 gene

Genome Databases showing MCM7 gene

Other Databases showing MCM7 gene

Specialized Databases showing MCM7 gene

Intellectual Property
for MCM7 gene

Products
for MCM7 gene

View Random Gene

Advanced Search

Export list of displayed genes

MCM7 Gene

minichromosome maintenance complex component 7

Aliasesfor MCM7 gene

Summariesfor MCM7 gene

Genomic Viewsfor MCM7 gene

Proteinsfor MCM7 gene

Protein Domains /Familiesfor MCM7 gene

Functionfor MCM7 gene

Pathways & Interactionsfor MCM7 gene

Drugs & Compoundsfor MCM7 gene

Transcriptsfor MCM7 gene

Expression for MCM7 gene

Orthologsfor MCM7 gene

Paralogsfor MCM7 gene

Genomic Variantsfor MCM7 gene

Disorders / Diseasesfor MCM7 gene

Publicationsfor MCM7 gene

External Searches for MCM7 gene

Genome Databases showing MCM7 gene

Other Databases showing MCM7 gene

Specialized Databases showing MCM7 gene

Intellectual Propertyfor MCM7 gene

Productsfor MCM7 gene

View Random Gene

Aliases
for MCM7 gene

Summaries
for MCM7 gene

Genomic Views
for MCM7 gene

Proteins
for MCM7 gene

Protein Domains /
Families
for MCM7 gene

Function
for MCM7 gene

Pathways & Interactions
for MCM7 gene

Drugs & Compounds
for MCM7 gene

Transcripts
for MCM7 gene

Expression
for MCM7 gene

Orthologs
for MCM7 gene

Paralogs
for MCM7 gene

Genomic Variants
for MCM7 gene

Disorders / Diseases
for MCM7 gene

Publications
for MCM7 gene

Intellectual Property
for MCM7 gene

Products
for MCM7 gene