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Aliases for MCM7 Gene

Aliases for MCM7 Gene

  • Minichromosome Maintenance Complex Component 7 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 104 2 3
  • CDC47 Homolog 3 4
  • P1.1-MCM3 3 4
  • CDC47 3 4
  • MCM2 3 4
  • MCM7 Minichromosome Maintenance Deficient 7 (S. Cerevisiae) 2
  • Minichromosome Maintenance Deficient (S. Cerevisiae) 7 2
  • Minichromosome Maintenance Deficient 7 3
  • DNA Replication Licensing Factor MCM7 3
  • Homolog Of S. Cerevisiae Cdc47 3
  • EC 3.6.4.12 4
  • PPP1R104 3
  • P1CDC47 3
  • PNAS146 3
  • P85MCM 3

External Ids for MCM7 Gene

Previous HGNC Symbols for MCM7 Gene

  • MCM2

Previous GeneCards Identifiers for MCM7 Gene

  • GC07M098224
  • GC07M099287
  • GC07M099301
  • GC07M099335
  • GC07M099528
  • GC07M099690
  • GC07M094326

Summaries for MCM7 Gene

Entrez Gene Summary for MCM7 Gene

  • The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for MCM7 Gene

MCM7 (Minichromosome Maintenance Complex Component 7) is a Protein Coding gene. Diseases associated with MCM7 include Cervix Endometriosis and Melanoacanthoma. Among its related pathways are DNA Damage and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include ATPase activity and ATP-dependent DNA helicase activity.

UniProtKB/Swiss-Prot for MCM7 Gene

  • Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.

Gene Wiki entry for MCM7 Gene

Additional gene information for MCM7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCM7 Gene

Genomics for MCM7 Gene

Regulatory Elements for MCM7 Gene

Enhancers for MCM7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H100076 1.2 ENCODE 12.4 +21.8 21837 6 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A MEF2D SSRP1 ZNF610 AP4M1 ZSCAN25 SRRT PPP1R35 TRIM4 GIGYF1 ZNF655 ZNF3 ENSG00000242798 MEPCE
GH07H100124 1.1 ENCODE 12.1 -24.7 -24734 4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 FOS TRIM4 MBLAC1 ZSCAN25 GIGYF1 SRRT AP4M1 ENSG00000242798 ZNF655 CNPY4 LOC100131859
GH07H100040 1.1 ENCODE dbSUPER 11 +60.2 60243 1 BCOR CTCF PKNOX1 ESRRA FOXA2 TAL1 JUN ZNF644 THRB RAD21 AP4M1 ZSCAN21 ZKSCAN1 COPS6 MIR93 MIR25 MIR106B MCM7 PILRA GC07P100039
GH07H100137 0.9 Ensembl ENCODE 11.3 -36.2 -36228 0 PKNOX1 GATA3 IKZF1 ELF1 NFE2 RUNX3 TCF7L2 FOXA1 PVRIG C7orf43 GAL3ST4 GPC2 STAG3 GATS AP4M1 MCM7 MIR106B MIR25
GH07H100061 0.8 ENCODE 11.9 +40.1 40112 0 BCOR HDGF PKNOX1 ARNT TAL1 TCF12 CC2D1A GATA2 POLR2A NCOR1 COPS6 MIR106B MIR25 MIR93 MCM7 ZKSCAN1 TRIM4 GC07M100088 PIR44616 PIR43713
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MCM7 on UCSC Golden Path with GeneCards custom track

Promoters for MCM7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215738 740 2401 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D ZNF610

Genomic Location for MCM7 Gene

Chromosome:
7
Start:
100,092,728 bp from pter
End:
100,101,940 bp from pter
Size:
9,213 bases
Orientation:
Minus strand

Genomic View for MCM7 Gene

Genes around MCM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCM7 Gene

Proteins for MCM7 Gene

  • Protein details for MCM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33993-MCM7_HUMAN
    Recommended name:
    DNA replication licensing factor MCM7
    Protein Accession:
    P33993
    Secondary Accessions:
    • A4D2A1
    • A4D2A2
    • E9PGN9
    • Q15076
    • Q96D34
    • Q96GL1

    Protein attributes for MCM7 Gene

    Size:
    719 amino acids
    Molecular mass:
    81308 Da
    Quaternary structure:
    • Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (Probable). Interacts with the ATR-ATRIP complex and with RAD17. Interacts with TIPIN. Interacts with MCMBP. Interacts with ANKRD17.
    Miscellaneous:
    • Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.

    Alternative splice isoforms for MCM7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCM7 Gene

Post-translational modifications for MCM7 Gene

  • O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
  • Ubiquitination at Lys15, Lys28, Lys32, Lys75, Lys89, Lys96, posLast=145145, Lys231, posLast=236236, Lys308, posLast=335335, posLast=387387, Lys471, posLast=557557, Lys569, posLast=596596, Lys627, posLast=641641, and posLast=648648
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MCM7 Gene

Domains & Families for MCM7 Gene

Gene Families for MCM7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for MCM7 Gene

Graphical View of Domain Structure for InterPro Entry

P33993

UniProtKB/Swiss-Prot:

MCM7_HUMAN :
  • Belongs to the MCM family.
Family:
  • Belongs to the MCM family.
genes like me logo Genes that share domains with MCM7: view

Function for MCM7 Gene

Molecular function for MCM7 Gene

GENATLAS Biochemistry:
cell division cycle 47 (CDC47) homolog,early S-phase-like 7,participating in the cell cycle control of genome duplication
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.

Enzyme Numbers (IUBMB) for MCM7 Gene

Gene Ontology (GO) - Molecular Function for MCM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003677 contributes_to DNA binding TAS 15538388
GO:0003678 DNA helicase activity IEA --
GO:0003697 single-stranded DNA binding IEA --
GO:0004003 contributes_to ATP-dependent DNA helicase activity IDA 9305914
genes like me logo Genes that share ontologies with MCM7: view
genes like me logo Genes that share phenotypes with MCM7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MCM7
  • Applied Biological Materials Clones for MCM7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCM7 Gene

Localization for MCM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCM7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCM7 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MCM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region IDA 19135898
GO:0000785 chromatin TAS 8798650
GO:0005634 nucleus IDA 21383955
GO:0005654 nucleoplasm TAS --
GO:0005730 NOT nucleolus IDA 21383955
genes like me logo Genes that share ontologies with MCM7: view

Pathways & Interactions for MCM7 Gene

genes like me logo Genes that share pathways with MCM7: view

Pathways by source for MCM7 Gene

SIGNOR curated interactions for MCM7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MCM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0006260 DNA replication TAS --
GO:0006268 DNA unwinding involved in DNA replication IEA --
GO:0006270 DNA replication initiation IEA --
GO:0006974 cellular response to DNA damage stimulus IMP 15538388
genes like me logo Genes that share ontologies with MCM7: view

Drugs & Compounds for MCM7 Gene

(5) Drugs for MCM7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
atorvastatin Approved Pharma Competitive, Inhibitor 0
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Nutra Agonist 0

(1) Additional Compounds for MCM7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MCM7: view

Transcripts for MCM7 Gene

Unigene Clusters for MCM7 Gene

Minichromosome maintenance complex component 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MCM7
  • Applied Biological Materials Clones for MCM7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MCM7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14 ^ 15 ^
SP1: - - - - - -
SP2: - - - -
SP3: -
SP4: - - - - -
SP5: - -
SP6: - - - - -
SP7: -
SP8: -
SP9: - - - - -
SP10: - -
SP11: -
SP12: - - - - - - - - - - - - - - -
SP13:
SP14:

ExUns: 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b
SP1: -
SP2: -
SP3: -
SP4: - - - - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - -
SP13:
SP14:

Relevant External Links for MCM7 Gene

GeneLoc Exon Structure for
MCM7
ECgene alternative splicing isoforms for
MCM7

Expression for MCM7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MCM7 Gene

Protein differential expression in normal tissues from HIPED for MCM7 Gene

This gene is overexpressed in Liver (15.2), Lymph node (14.3), and Fetal ovary (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MCM7 Gene



Protein tissue co-expression partners for MCM7 Gene

NURSA nuclear receptor signaling pathways regulating expression of MCM7 Gene:

MCM7

SOURCE GeneReport for Unigene cluster for MCM7 Gene:

Hs.438720

Evidence on tissue expression from TISSUES for MCM7 Gene

  • Nervous system(5)
  • Lung(4.8)
  • Skin(4.5)
  • Intestine(4.2)
  • Blood(4.1)
  • Kidney(3.8)
  • Liver(3.6)
  • Eye(3.5)
  • Muscle(3.5)
  • Lymph node(2.6)
  • Stomach(2.2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with MCM7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCM7 Gene

Orthologs for MCM7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCM7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCM7 33 34
  • 99.4 (n)
oppossum
(Monodelphis domestica)
Mammalia MCM7 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MCM7 33 34
  • 89.34 (n)
dog
(Canis familiaris)
Mammalia MCM7 33 34
  • 88.73 (n)
rat
(Rattus norvegicus)
Mammalia Mcm7 33
  • 87.07 (n)
mouse
(Mus musculus)
Mammalia Mcm7 33 16 34
  • 86.93 (n)
lizard
(Anolis carolinensis)
Reptilia MCM7 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mcm7 33
  • 74.12 (n)
Str.6411 33
African clawed frog
(Xenopus laevis)
Amphibia LOC397852 33
zebrafish
(Danio rerio)
Actinopterygii mcm7 33 34
  • 73.57 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9124 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005800 33
  • 64.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mcm7 35 33 34
  • 63.7 (n)
worm
(Caenorhabditis elegans)
Secernentea mcm-7 35 33 34
  • 54.57 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR041W 33
  • 54.01 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E23189g 33
  • 52.07 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCM7 33 34 36
  • 51.25 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PRL 33
  • 53.7 (n)
soybean
(Glycine max)
eudicotyledons Gma.10482 33
rice
(Oryza sativa)
Liliopsida Os12g0560700 33
  • 53.13 (n)
Os.24951 33
wheat
(Triticum aestivum)
Liliopsida Ta.7561 33
corn
(Zea mays)
Liliopsida Zm.3812 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8017 34
  • 69 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU08119 33
  • 56.38 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mcm7 33
  • 51.66 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4257 33
Species where no ortholog for MCM7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MCM7 Gene

ENSEMBL:
Gene Tree for MCM7 (if available)
TreeFam:
Gene Tree for MCM7 (if available)

Paralogs for MCM7 Gene

(7) SIMAP similar genes for MCM7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MCM7: view

No data available for Paralogs for MCM7 Gene

Variants for MCM7 Gene

Sequence variations from dbSNP and Humsavar for MCM7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs752598529 Pathogenic 100,102,939(+) GTATA(C/G)GAACT intron-variant, upstream-variant-2KB, reference, stop-gained, utr-variant-5-prime
rs797045249 Likely pathogenic 100,101,746(+) CTCCA(-/A)GGGGG upstream-variant-2KB, reference, frameshift-variant, utr-variant-5-prime
rs41280965 Likely benign 100,102,755(+) TCTCC(C/T)TTCAG intron-variant, upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs138437966 Uncertain significance 100,102,942(+) TACGA(A/C)CTCCT intron-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs367614875 Uncertain significance 100,102,716(+) AGCGG(C/T)CTCTA intron-variant, upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MCM7 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv469687 CNV loss 16826518
nsv510966 OTHER complex 20534489
nsv607931 CNV loss 21841781
nsv951384 CNV deletion 24416366

Variation tolerance for MCM7 Gene

Residual Variation Intolerance Score: 9.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.40; 81.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCM7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCM7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCM7 Gene

Disorders for MCM7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MCM7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cervix endometriosis
  • cervical endometriosis
melanoacanthoma
- elite association - COSMIC cancer census association via MalaCards
Search MCM7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MCM7

Genetic Association Database (GAD)
MCM7
Human Genome Epidemiology (HuGE) Navigator
MCM7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCM7
genes like me logo Genes that share disorders with MCM7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MCM7 Gene

Publications for MCM7 Gene

  1. Identification and characterization of a novel component of the human minichromosome maintenance complex. (PMID: 17296731) Sakwe AM … Frappier L (Molecular and cellular biology 2007) 3 4 22 60
  2. Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. (PMID: 15210935) Cortez D … Elledge SJ (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 22 60
  3. Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. (PMID: 15538388) Tsao CC … Abraham RT (The EMBO journal 2004) 3 4 22 60
  4. Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication. (PMID: 7842741) Nakatsuru S … Nakamura Y (Cytogenetics and cell genetics 1995) 2 3 4 60
  5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 45 60

Products for MCM7 Gene

  • Addgene plasmids for MCM7

Sources for MCM7 Gene

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