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Aliases for MCM7 Gene

Aliases for MCM7 Gene

  • Minichromosome Maintenance Complex Component 7 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 104 2 3
  • CDC47 Homolog 3 4
  • P1.1-MCM3 3 4
  • CDC47 3 4
  • MCM2 3 4
  • MCM7 Minichromosome Maintenance Deficient 7 (S. Cerevisiae) 2
  • Minichromosome Maintenance Deficient (S. Cerevisiae) 7 2
  • Minichromosome Maintenance Deficient 7 3
  • DNA Replication Licensing Factor MCM7 3
  • Homolog Of S. Cerevisiae Cdc47 3
  • EC 3.6.4.12 4
  • PPP1R104 3
  • P1CDC47 3
  • PNAS146 3
  • P85MCM 3

External Ids for MCM7 Gene

Previous HGNC Symbols for MCM7 Gene

  • MCM2

Previous GeneCards Identifiers for MCM7 Gene

  • GC07M098224
  • GC07M099287
  • GC07M099301
  • GC07M099335
  • GC07M099528
  • GC07M099690
  • GC07M094326

Summaries for MCM7 Gene

Entrez Gene Summary for MCM7 Gene

  • The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for MCM7 Gene

MCM7 (Minichromosome Maintenance Complex Component 7) is a Protein Coding gene. Diseases associated with MCM7 include Cervix Endometriosis and Melanoacanthoma. Among its related pathways are DNA strand elongation and E2F mediated regulation of DNA replication. GO annotations related to this gene include ATPase activity and ATP-dependent DNA helicase activity.

UniProtKB/Swiss-Prot for MCM7 Gene

  • Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.

Gene Wiki entry for MCM7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCM7 Gene

Genomics for MCM7 Gene

Regulatory Elements for MCM7 Gene

Enhancers for MCM7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MCM7 on UCSC Golden Path with GeneCards custom track

Promoters for MCM7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MCM7 Gene

Chromosome:
7
Start:
100,092,728 bp from pter
End:
100,101,940 bp from pter
Size:
9,213 bases
Orientation:
Minus strand

Genomic View for MCM7 Gene

Genes around MCM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCM7 Gene

Proteins for MCM7 Gene

  • Protein details for MCM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33993-MCM7_HUMAN
    Recommended name:
    DNA replication licensing factor MCM7
    Protein Accession:
    P33993
    Secondary Accessions:
    • A4D2A1
    • A4D2A2
    • E9PGN9
    • Q15076
    • Q96D34
    • Q96GL1

    Protein attributes for MCM7 Gene

    Size:
    719 amino acids
    Molecular mass:
    81308 Da
    Quaternary structure:
    • Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (Probable). Interacts with the ATR-ATRIP complex and with RAD17. Interacts with TIPIN. Interacts with MCMBP. Interacts with ANKRD17.
    Miscellaneous:
    • Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.

    Alternative splice isoforms for MCM7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCM7 Gene

Post-translational modifications for MCM7 Gene

  • O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
  • Ubiquitination at Lys 15, Lys 28, Lys 32, Lys 75, Lys 89, Lys 96, Lys 145, Lys 231, Lys 236, Lys 308, Lys 335, Lys 387, Lys 471, Lys 557, Lys 569, Lys 596, Lys 627, Lys 641, and Lys 648
  • Modification sites at PhosphoSitePlus

Other Protein References for MCM7 Gene

No data available for DME Specific Peptides for MCM7 Gene

Domains & Families for MCM7 Gene

Suggested Antigen Peptide Sequences for MCM7 Gene

Graphical View of Domain Structure for InterPro Entry

P33993

UniProtKB/Swiss-Prot:

MCM7_HUMAN :
  • Contains 1 MCM domain.
  • Belongs to the MCM family.
Domain:
  • Contains 1 MCM domain.
Family:
  • Belongs to the MCM family.
genes like me logo Genes that share domains with MCM7: view

Function for MCM7 Gene

Molecular function for MCM7 Gene

GENATLAS Biochemistry:
cell division cycle 47 (CDC47) homolog,early S-phase-like 7,participating in the cell cycle control of genome duplication
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.

Enzyme Numbers (IUBMB) for MCM7 Gene

Gene Ontology (GO) - Molecular Function for MCM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 contributes_to DNA binding TAS 15538388
GO:0003678 DNA helicase activity IEA --
GO:0003697 single-stranded DNA binding IEA --
GO:0004003 contributes_to ATP-dependent DNA helicase activity IDA 9305914
GO:0005515 protein binding IPI 9705868
genes like me logo Genes that share ontologies with MCM7: view
genes like me logo Genes that share phenotypes with MCM7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MCM7

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCM7 Gene

Localization for MCM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCM7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCM7 Gene COMPARTMENTS Subcellular localization image for MCM7 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MCM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region IDA 19135898
GO:0000785 chromatin TAS 8798650
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MCM7: view

Pathways & Interactions for MCM7 Gene

genes like me logo Genes that share pathways with MCM7: view

Pathways by source for MCM7 Gene

SIGNOR curated interactions for MCM7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MCM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0006260 DNA replication TAS --
GO:0006268 DNA unwinding involved in DNA replication IEA --
GO:0006270 DNA replication initiation IEA --
GO:0006974 cellular response to DNA damage stimulus IMP 15538388
genes like me logo Genes that share ontologies with MCM7: view

Drugs & Compounds for MCM7 Gene

(5) Drugs for MCM7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
atorvastatin Approved Pharma Competitive, Inhibitor 0
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for MCM7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MCM7: view

Transcripts for MCM7 Gene

Unigene Clusters for MCM7 Gene

Minichromosome maintenance complex component 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MCM7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCM7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14 ^ 15 ^
SP1: - - - - - -
SP2: - - - -
SP3: -
SP4: - - - - -
SP5: - -
SP6: - - - - -
SP7: -
SP8: -
SP9: - - - - -
SP10: - -
SP11: -
SP12: - - - - - - - - - - - - - - -
SP13:
SP14:

ExUns: 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b
SP1: -
SP2: -
SP3: -
SP4: - - - - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - -
SP13:
SP14:

Relevant External Links for MCM7 Gene

GeneLoc Exon Structure for
MCM7
ECgene alternative splicing isoforms for
MCM7

Expression for MCM7 Gene

mRNA expression in normal human tissues for MCM7 Gene

Protein differential expression in normal tissues from HIPED for MCM7 Gene

This gene is overexpressed in Liver (15.2), Lymph node (14.3), and Fetal ovary (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MCM7 Gene



Protein tissue co-expression partners for MCM7 Gene

NURSA nuclear receptor signaling pathways regulating expression of MCM7 Gene:

MCM7

SOURCE GeneReport for Unigene cluster for MCM7 Gene:

Hs.438720
genes like me logo Genes that share expression patterns with MCM7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MCM7 Gene

Orthologs for MCM7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCM7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MCM7 34
  • 89.34 (n)
  • 96.38 (a)
MCM7 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCM7 34
  • 88.73 (n)
  • 96.24 (a)
MCM7 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MCM7 34
  • 99.4 (n)
  • 99.86 (a)
MCM7 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcm7 34
  • 87.07 (n)
  • 94.3 (a)
mouse
(Mus musculus)
Mammalia Mcm7 16
Mcm7 35
  • 93 (a)
OneToOne
Mcm7 34
  • 86.93 (n)
  • 92.77 (a)
oppossum
(Monodelphis domestica)
Mammalia MCM7 35
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCM7 35
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397852 34
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6411 34
mcm7 34
  • 74.12 (n)
  • 84.78 (a)
zebrafish
(Danio rerio)
Actinopterygii mcm7 34
  • 73.57 (n)
  • 80.81 (a)
mcm7 35
  • 80 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9124 34
fruit fly
(Drosophila melanogaster)
Insecta Mcm7 36
  • 69 (a)
Mcm7 34
  • 63.7 (n)
  • 67.45 (a)
Mcm7 35
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005800 34
  • 64.2 (n)
  • 66.99 (a)
worm
(Caenorhabditis elegans)
Secernentea mcm-7 36
  • 56 (a)
mcm-7 34
  • 54.57 (n)
  • 52.54 (a)
mcm-7 35
  • 49 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR041W 34
  • 54.01 (n)
  • 50.7 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E23189g 34
  • 52.07 (n)
  • 52.21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCM7 35
  • 42 (a)
OneToOne
MCM7 37
MCM7 34
  • 51.25 (n)
  • 50.07 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PRL 34
  • 53.7 (n)
  • 52.36 (a)
soybean
(Glycine max)
eudicotyledons Gma.10482 34
corn
(Zea mays)
Liliopsida Zm.3812 34
wheat
(Triticum aestivum)
Liliopsida Ta.7561 34
rice
(Oryza sativa)
Liliopsida Os12g0560700 34
  • 53.13 (n)
  • 50.85 (a)
Os.24951 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4257 34
bread mold
(Neurospora crassa)
Ascomycetes NCU08119 34
  • 56.38 (n)
  • 52.44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8017 35
  • 69 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mcm7 34
  • 51.66 (n)
  • 50.77 (a)
Species where no ortholog for MCM7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MCM7 Gene

ENSEMBL:
Gene Tree for MCM7 (if available)
TreeFam:
Gene Tree for MCM7 (if available)

Paralogs for MCM7 Gene

(7) SIMAP similar genes for MCM7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MCM7: view

No data available for Paralogs for MCM7 Gene

Variants for MCM7 Gene

Sequence variations from dbSNP and Humsavar for MCM7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2070215 - 100,099,174(-) CAGCA(A/G)CAAGC reference, missense, utr-variant-5-prime
VAR_014817 -
rs2307348 - 100,099,339(-) GAGTC(A/G)GGACC reference, missense, utr-variant-5-prime
rs2178024 -- 100,097,820(-) CAGGG(G/T)AGAGA intron-variant
rs2307345 -- 100,097,403(-) CAGGG(C/T)TGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCM7 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv469687 CNV loss 16826518
nsv510966 OTHER complex 20534489
nsv607931 CNV loss 21841781
nsv951384 CNV deletion 24416366

Variation tolerance for MCM7 Gene

Residual Variation Intolerance Score: 9.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.40; 81.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCM7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCM7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCM7 Gene

Disorders for MCM7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MCM7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cervix endometriosis
  • cervical endometriosis
melanoacanthoma
keratosis, seborrheic, somatic
  • seborrheic keratosis
- elite association - COSMIC cancer census association via MalaCards
Search MCM7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MCM7

Genetic Association Database (GAD)
MCM7
Human Genome Epidemiology (HuGE) Navigator
MCM7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCM7
genes like me logo Genes that share disorders with MCM7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MCM7 Gene

Publications for MCM7 Gene

  1. Identification and characterization of a novel component of the human minichromosome maintenance complex. (PMID: 17296731) Sakwe A.M. … Frappier L. (Mol. Cell. Biol. 2007) 3 4 22 65
  2. Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. (PMID: 15210935) Cortez D. … Elledge S.J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 22 65
  3. Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. (PMID: 15538388) Tsao C.-C. … Abraham R.T. (EMBO J. 2004) 3 4 22 65
  4. Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication. (PMID: 7842741) Nakatsuru S. … Nakamura Y. (Cytogenet. Cell Genet. 1995) 2 3 4 65
  5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 65

Products for MCM7 Gene

  • Addgene plasmids for MCM7

Sources for MCM7 Gene

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