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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MCM6 Gene

protein-coding GIFtS: 64
GCID: GC02M136619

minichromosome maintenance complex component 6

(Previous names: minichromosome maintenance deficient (mis5, S. pombe) 6,...)

Explore 16 diseases affiliated with
MCM6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Minichromosome Maintenance Complex Component 6¹ ²		P105MCM²
Mis5¹ ²		DNA Replication Licensing Factor MCM6²
Minichromosome Maintenance Deficient (Mis5, S. Pombe) 6¹ ²		MCM6 Minichromosome Maintenance Deficient 6 (MIS5 Homolog, S. Pombe)²
MCM6 Minichromosome Maintenance Deficient 6 (MIS5 Homolog, S. Pombe) (S. Cerevisiae)¹		EC 3.6.4.12³
Minichromosome Maintenance Deficient 6 Homolog (S. Cerevisiae)¹		P105MCM²
MCG40308²

External Ids:	HGNC: 6949¹	Entrez Gene: 4175²	Ensembl: ENSG00000076003⁷	OMIM: 601806⁵	UniProtKB: Q14566³

Export aliases for MCM6 gene to outside databases

Previous GC identifers: GC02M134252 GC02M134894 GC02M136807 GC02M136430 GC02M136313 GC02M128590

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MCM6:

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are

essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM

proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of

replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this

protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The

phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of

DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential

transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance

in early adulthood. (provided by RefSeq, May 2012)

UniProtKB/Swiss-Prot: MCM6_HUMAN, Q14566

Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential

for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in

the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure

of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the

adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex

helicase activity

Gene Wiki entry for MCM6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022135.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MCM6 gene promoter:
HTF Pax-2 Pax-2a Tal-1beta C/EBPalpha Max FAC1 ITF-2 ATF6 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MCM6 promoter sequence

Search SABiosciences Chromatin IP Primers for MCM6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCM6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21 Ensembl cytogenetic band: 2q21.3 HGNC cytogenetic band: 2q14-q21

MCM6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCM6 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M136619: view genomic region (about GC identifiers)

Start:	136,597,196 bp from pter	End:	136,634,011 bp from pter
Size:	36,816 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MCM6_HUMAN, Q14566 (See protein sequence)

Recommended Name: DNA replication licensing factor MCM6

Size: 821 amino acids; 92889 Da

Subunit: Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order

MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (By simililarity). May interact with MCM10. Interacts with TIPIN. Interacts with CDT1.

Interacts with MCMBP

Subcellular location: Nucleus. Note=Binds to chromatin during G1 and detach from it during S phase

Miscellaneous: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric

complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase

activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex

2 PDB 3D structures from and Proteopedia for MCM6:

2KLQ (3D)

2LE8 (3D)

Secondary accessions: B2R6H2 Q13504 Q99859

Explore the universe of human proteins at neXtProt for MCM6: NX_Q14566

Post-translational modifications:

O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q14566

MCM6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005906.2

ENSEMBL proteins:

ENSP00000264156

Reactome Protein details: Q14566
Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MCM6

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	9286856
GO:0005654	nucleoplasm	TAS	--
GO:0005730	NOT nucleolus	IDA	--
GO:0042555	MCM complex	IDA	17296731

MCM6 for ontologies About GeneDecksing

MCM6 Antibody Products:

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	ThermoFisher Antibodies for MCM6

Assay Products for MCM6:

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	Uscn ELISAs and CLIAs for MCM6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MCM6 for domains About GeneDecksing

5 InterPro domains/families:

IPR018525 MCM_CS

IPR012340 NA-bd_OB-fold

IPR004039 Rubredoxin-type_fold

IPR001208 MCM_DNA-dep_ATPase

IPR008049 MCM6

Graphical View of Domain Structure for InterPro Entry Q14566

ProtoNet protein and cluster: Q14566

2 Blocks protein families:

IPB001208 MCM family

IPB008049 Mini-chromosome maintenance (MCM) protein 6 signature

UniProtKB/Swiss-Prot: MCM6_HUMAN, Q14566

Similarity: Belongs to the MCM family

Similarity: Contains 1 MCM domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MCM6_HUMAN, Q14566

Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential

for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in

the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure

of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the

adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex

helicase activity

Catalytic activity: ATP + H(2)O = ADP + phosphate

Genatlas biochemistry entry for MCM6:

cell division cycle,early S-phase-like-6,participating in the cell cycle control of genome duplication

Enzyme Number (IUBMB): EC 3.6.4.12¹

miRNA Products:		OriGene 3'-UTR Clone: MCM6 Browse MicroRNA Expression Plasmids
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		hsa-miR-4282 hsa-miR-570
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for MCM6

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		Search LifeMap BioReagents cell lines for MCM6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM6

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003678	DNA helicase activity	--	--
GO:0003697	single-stranded DNA binding	IEA	--
GO:0004003	contributes to ATP-dependent DNA helicase activity	IDA	9305914
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	NAS	9286856

MCM6 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for MCM6:

Decreased viability of wild-ty

Increased cell death in HCT116

Synthetic lethal with Ras

Animal Models:
5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mcm6):

cellular

growth/size

hematopoietic system

mortality/aging

tumorigenesis

MCM6 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/11 pathways (see all 11)
Assembly of the pre-replicative complex	0.77	M/G1 Transition	0.62
Switching of origins to a post-replicative state	0.70	Synthesis of DNA	0.51
Orc1 removal from chromatin	0.70	DNA Replication	0.49
Regulation of DNA replication	0.68	Cell Cycle Checkpoints	0.42

Cell cycle

	Cell cycle	1.00			G1 to S cell cycle control	0.38
	Cell cycle	0.57

Lagging Strand Synthesis

	DNA strand elongation	0.65			Unwinding of DNA	0.00
	DNA replication	0.56

Cell cycle_Start of DNA replication in early S phase

Cell cycle_Start of DNA replication in early S phase

1.00

Cell cycle Start of DNA replication in early S phase

0.98

Activation of ATR in response to replication stress

Activation of ATR in response to replication stress

1.00

G2/M Checkpoints

0.86

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for MCM6

	Meiosis
	Cell cycle Start of DNA replication in early S phase

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MCM6

Cell Cycle Control of Chromosomal Replication

1 GeneGo (Thomson Reuters) Pathway for MCM6

Cell cycle Start of DNA replication in early S phase

3 BioSystems Pathways for MCM6

	G1 to S cell cycle control
	Cell cycle
	DNA Replication

5/21 Reactome Pathways for MCM6 (see all 21)

	Activation of ATR in response to replication stress
	Mitotic G1-G1/S phases
	DNA Replication
	Removal of licensing factors from origins
	Cell Cycle

2 Kegg Pathways (Kegg details for MCM6):

	DNA replication
	Cell cycle

MCM6 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MCM6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/200 Interacting proteins for MCM6 (Q14566^{1, 2, 3} ENSP00000264156⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 200)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³, ENSP00000352980⁴	I2D: score=3 STRING: ENSP00000352980
HIST1H4L	P62805³, ENSP00000348258⁴	I2D: score=3 STRING: ENSP00000348258
HIST1H4B	P62805³	I2D: score=3
HIST1H4C	P62805³	I2D: score=3
HIST1H4D	P62805³	I2D: score=3

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000084	S phase of mitotic cell cycle	TAS	--
GO:0000216	M/G1 transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--

MCM6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MCM6 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MCM6

1 HMDB Compound for MCM6 About this table

Compound	Synonyms	CAS #	PubMed Ids
Atorvastatin	Atorvastatin acid (see all 4)	134523-00-5	--

1 Novoseek chemical compound relationship for MCM6 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
atp	4.68	2	11854416 (1), 16369567 (1)

Search CenterWatch for drugs/clinical trials and news about MCM6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MCM6 gene:

NM_005915.5

Unigene Cluster for MCM6:

Minichromosome maintenance complex component 6

Hs.444118 [show with all ESTs]

Unigene Representative Sequence: NM_005915

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000264156(uc002tuw.3) ENST00000492091 ENST00000483902

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		hsa-miR-4282 hsa-miR-570
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Additional cDNA sequence:

AK299236.1 AK303455.1 AK312575.1 BC008774.1 BC020268.1 BC032374.1 D84557.1 U46838.1

14 DOTS entries:

DT.101981070 DT.317585 DT.121025165 DT.92448645 DT.100671764 DT.102712 DT.121025168 DT.317584

DT.40216061 DT.92029959 DT.95162135 DT.95162137 DT.95338893 DT.95162140

24/309 AceView cDNA sequences (see all 309):

CB124587 AW575472 BC008774 BI870675 BM694541 AA132164 AI744803 BP367387

CA419174 BP339859 BQ688139 BQ710328 BU176030 AA291719 BM796863 BM835338

AU142944 AW768506 AU127718 BQ302962 BM461535 AA828103 BQ424418 BG114203

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MCM6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

MCM6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Atrioventricular Canal

Atrioventricular Canal Cells

Myocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MCM6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MCM6

SOURCE GeneReport for Unigene cluster: Hs.444118

SABiosciences Expression via Pathway-Focused PCR Arrays including MCM6:

Nephrotoxicity in human mouse rat

Cardiotoxicity in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCM6 gene from 9/38 species (see all 38) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MCM6¹	minichromosome maintenance complex component 6	79.52(n) 88.21(a)		424295 NM_001006527.1 NP_001006527.1
lizard (Anolis carolinensis)	Reptilia	MCM6⁶	--	85(a)	1 ↔ 1	1(96763400-96784343)
African clawed frog (Xenopus laevis)	Amphibia	AF031139.1²	--	76.18(n)		AF031139.1
zebrafish (Danio rerio)	Actinopterygii	CA975689.1²	--	74.21(n)		CA975689.1
fruit fly (Drosophila melanogaster)	Insecta	Mcm6^{1 , 3}	oogenesis chromatin binding³ Minichromosome maintenance 6¹	62(a)³ 60.5(n)¹ 64.25(a)¹		31603¹ NM_078510.2¹ NP_511065.1¹
worm (Caenorhabditis elegans)	Secernentea	mcm-6¹	Protein MCM-6	57.2(n) 57.29(a)		176385 NM_001027840.2 NP_001023011.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	MCM6(YGL201C)⁴ MCM6¹	Protein involved in DNA replication; component of the more⁴ Mcm6p¹	52.65(n)¹ 50.14(a)¹		7(120907-117854)⁴ 852673^{1, 4} NP_011314.2^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	MCM6¹	minichromosome maintenance protein 6	53.18(n) 47.66(a)		834492 NM_148088.1 NP_680393.1
rice (Oryza sativa)	Liliopsida	AK065677.1²	--	72.94(n)		AK065677.1

ENSEMBL Gene Tree for MCM6 (if available)
TreeFam Gene Tree for MCM6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: MCM6_HUMAN, Q14566

Polymorphism: Intronic variations in MCM6 upstream from the LCT gene are associated with adult-type hypolactasia

[MIM:223100] leading to lactose intolerance, or with lactase persistance. Lactose intolerance is a normal

physiological phenomenon caused by developmental down-regulation of lactase activity during childhood or early

adulthood. A non-coding variation in MCM6 affects the transcriptional regulation of the LCT gene resulting in

down-regulation of lactase activity. However, the majority of Northern Europeans and some African populations have the

ability to maintain lactase activity and digest lactose throughout life (lactase persistence)

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113198705^1,2		--	128590073(+)	`TCTTGA/GGTTCA`	1	--	int¹		1	CSA	1
rs4988288^1,2	C,F,H,	--	128590445(-)	`GGCAAA/GCATTA`	1	--	ut3¹		6	NS WA	1062
rs4988287^1,2	C,F,A,H,	--	128590460(-)	`ATTTTA/TAAAAT`	1	--	ut3¹		4	NS NA WA	276
rs4988286^1,2	C,F,H,	--	128590763(-)	`CAACAG/CATGGC`	1	--	ut3¹ ese³		16	NS EA WA NA CSA	1360
rs4988284^1,2	H	--	128591108(-)	`GAGTCA/GTTAGA`	1	--	ut3¹ ese³		4	NS EA	434
rs3739021^1,2	F	--	128591149(-)	`AGGTAG/TAACTG`	1	--	ut3¹ ese³		1	EA	1498
rs3087347^1,2	C,F,H,	--	128591237(-)	`ATTGGA/GTTTCT`	1	--	ut3¹		9	NA NS EA WA CSA	870
rs11656^1,2	C,F,A,	--	128591288(-)	`CAGCTA/TCTGCT`	1	--	ut3¹ ese³		4	NA NS MN WA	640
rs3087346^1,2	C,F,H	--	128591321(-)	`GTCCTA/CTTGAG`	1	--	ut3¹		5	NA NS EA	620
rs4988282^1,2	C,F,H,	--	128591984(-)	`AATTTT/CCCACA`	1	--	int¹		6	NS EA CSA WA	582

HapMap Linkage Disequilibrium report for MCM6 (136597196 - 136634011 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MCM6: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MCM6

DNA2.0 Custom Variant and Variant Library Synthesis for MCM6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MCM6 for disorders           About GeneDecksing

OMIM gene information: 601806
OMIM disorders: 223100
16 diseases for MCM6:    About MalaCards

lactose intolerance lactase persistance/nonpersistance hypolactasia mantle cell lymphoma

enchondroma craniopharyngioma merkel cell carcinoma renal cell carcinoma

hodgkin's lymphoma chondrosarcoma ovarian cancer lung cancer

breast cancer carcinoma hypoxia malaria

2 diseases from the University of Copenhagen DISEASES database for MCM6:

Lactose intolerance Craniopharyngioma

3 Novoseek disease relationships for MCM6 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
craniopharyngioma	58.8	8	17294730 (4), 17410335 (1)
retinoblastoma	24.4	1	12677008 (1)
tumors	7.2	11	17410335 (4), 15539383 (2), 17294730 (1)

Human Genome Epidemiology (HuGE) Navigator: MCM6 (7 documents)

Export disorders for MCM6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MCM6 gene, integrated from 9 sources (see all 127):
(articles sorted by number of sources associating them with MCM6)

Utopia: connect your pdf to the dynamic
world of online information

Human protein MCM6 on HeLa cell chromatin. (PubMed id 9516426)^{1, 2, 9} Holthoff H.P.... Knippers R. (1998)
Characterisation of a human homologue of a yeast cell division cycle gene, MCM6, located adjacent to the 5' end of the lactase gene on chromosome 2q21. (PubMed id 8977093)^{1, 2, 9} Harvey C.B....Swallow D.M. (1996)
Characterization and structure determination of the C dt1 binding domain of human minichromosome maintenance (Mcm) 6. (PubMed id 20202939)^{1, 2} Wei Z....Zhu G. (2010)
Identification and characterization of a novel component of the human minichromosome maintenance complex. (PubMed id 17296731)^{1, 2} Sakwe A.M....Frappier L. (2007)
Convergent adaptation of human lactase persistence in Africa and Europe. (PubMed id 17159977)^{1, 2} Tishkoff S.A.... Deloukas P. (2007)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells. (PubMed id 16899510)^{1, 2} Tsuji T....Jiang W. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of a variant associated with adult-type hypolactasia. (PubMed id 11788828)^{1, 2} Enattah N.S....Jaervelae I. (2002)
The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. (PubMed id 11095689)^{1, 2} Izumi M.... Hanaoka F. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4175	HGNC: 6949	AceView: MCM6	Ensembl:ENSG00000076003	euGenes: HUgn4175
ECgene: MCM6	Kegg: 4175	H-InvDB: MCM6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MCM6	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MCM6	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mcm6/

Intellectual Property for MCM6 gene
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Patent Information for MCM6 gene:
Search GeneIP for patents involving MCM6

GeneCards and IP:
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minichromosome maintenance complex component 6

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minichromosome maintenance complex component 6

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