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Aliases for MCM6 Gene

Aliases for MCM6 Gene

  • Minichromosome Maintenance Complex Component 6 2 3
  • Minichromosome Maintenance Deficient (Mis5, S. Pombe) 6 2 3
  • P105MCM 3 4
  • MCM6 Minichromosome Maintenance Deficient 6 (MIS5 Homolog, S. Pombe) (S. Cerevisiae) 2
  • MCM6 Minichromosome Maintenance Deficient 6 (MIS5 Homolog, S. Pombe) 3
  • Minichromosome Maintenance Deficient 6 Homolog (S. Cerevisiae) 2
  • DNA Replication Licensing Factor MCM6 3
  • MIS5 Homolog (S.Pombe) 2
  • EC 3.6.4.12 4
  • MCG40308 3
  • Mis5 3

External Ids for MCM6 Gene

Summaries for MCM6 Gene

Entrez Gene Summary for MCM6 Gene

  • The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012]

GeneCards Summary for MCM6 Gene

MCM6 (Minichromosome Maintenance Complex Component 6) is a Protein Coding gene. Diseases associated with MCM6 include lactase persistence/nonpersistence and lactose intolerance. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include identical protein binding and ATP-dependent DNA helicase activity.

UniProtKB/Swiss-Prot for MCM6 Gene

  • Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

Gene Wiki entry for MCM6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCM6 Gene

Genomics for MCM6 Gene

Genomic Location for MCM6 Gene

Start:
135,839,626 bp from pter
End:
135,876,477 bp from pter
Size:
36,852 bases
Orientation:
Minus strand

Genomic View for MCM6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCM6 Gene

Regulatory Elements for MCM6 Gene

Proteins for MCM6 Gene

  • Protein details for MCM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14566-MCM6_HUMAN
    Recommended name:
    DNA replication licensing factor MCM6
    Protein Accession:
    Q14566
    Secondary Accessions:
    • B2R6H2
    • Q13504
    • Q99859

    Protein attributes for MCM6 Gene

    Size:
    821 amino acids
    Molecular mass:
    92889 Da
    Quaternary structure:
    • Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (By simililarity). May interact with MCM10. Interacts with TIPIN. Interacts with CDT1. Interacts with MCMBP.
    Miscellaneous:
    • Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex

    Three dimensional structures from OCA and Proteopedia for MCM6 Gene

neXtProt entry for MCM6 Gene

Proteomics data for MCM6 Gene at MOPED

Post-translational modifications for MCM6 Gene

  • O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys108, Lys197, Lys205, Lys332, Lys407, Lys422, Lys486, Lys490, Lys517, Lys588, Lys599, Lys611, Lys643, Lys654, Lys744, and Lys775

Other Protein References for MCM6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MCM6 Gene

Domains for MCM6 Gene

Suggested Antigen Peptide Sequences for MCM6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14566

UniProtKB/Swiss-Prot:

MCM6_HUMAN
Domain:
  • Contains 1 MCM domain.:
    • Q14566
Family:
  • Belongs to the MCM family.:
    • Q14566
genes like me logo Genes that share domains with MCM6: view

No data available for Gene Families for MCM6 Gene

Function for MCM6 Gene

Molecular function for MCM6 Gene

GENATLAS Biochemistry: cell division cycle,early S-phase-like-6,participating in the cell cycle control of genome duplication
UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

Enzyme Numbers (IUBMB) for MCM6 Gene

Gene Ontology (GO) - Molecular Function for MCM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003678 DNA helicase activity --
GO:0003697 single-stranded DNA binding IEA --
GO:0004003 contributes_to ATP-dependent DNA helicase activity IDA 9305914
GO:0005515 protein binding IPI 11095689
genes like me logo Genes that share ontologies with MCM6: view
genes like me logo Genes that share phenotypes with MCM6: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MCM6 Gene

Localization for MCM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCM6 Gene

Nucleus. Note=Binds to chromatin during G1 and detach from it during S phase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCM6 Gene COMPARTMENTS Subcellular localization image for MCM6 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for MCM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 9286856
GO:0005654 nucleoplasm TAS --
GO:0042555 MCM complex IDA 17296731
genes like me logo Genes that share ontologies with MCM6: view

Pathways for MCM6 Gene

genes like me logo Genes that share pathways with MCM6: view

Pathways by source for MCM6 Gene

Gene Ontology (GO) - Biological Process for MCM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006260 DNA replication TAS --
GO:0006268 DNA unwinding involved in DNA replication IEA --
GO:0006270 DNA replication initiation IEA --
genes like me logo Genes that share ontologies with MCM6: view

Compounds for MCM6 Gene

(1) HMDB Compounds for MCM6 Gene

Compound Synonyms Cas Number PubMed IDs
Atorvastatin
  • Atorvastatin acid
134523-00-5

(1) Novoseek inferred chemical compound relationships for MCM6 Gene

Compound -log(P) Hits PubMed IDs
atp 4.68 2
genes like me logo Genes that share compounds with MCM6: view

Transcripts for MCM6 Gene

mRNA/cDNA for MCM6 Gene

Unigene Clusters for MCM6 Gene

Minichromosome maintenance complex component 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MCM6 Gene

No ASD Table

Relevant External Links for MCM6 Gene

GeneLoc Exon Structure for
MCM6
ECgene alternative splicing isoforms for
MCM6

Expression for MCM6 Gene

mRNA expression in normal human tissues for MCM6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCM6 Gene

SOURCE GeneReport for Unigene cluster for MCM6 Gene Hs.444118

genes like me logo Genes that share expressions with MCM6: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MCM6 Gene

Orthologs for MCM6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCM6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCM6 35
  • 99.92 (n)
  • 99.88 (a)
MCM6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MCM6 35
  • 93.06 (n)
  • 97.44 (a)
MCM6 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCM6 35
  • 92.85 (n)
  • 97.32 (a)
MCM6 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcm6 35
  • 88.31 (n)
  • 95.86 (a)
Mcm6 16
Mcm6 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCM6 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCM6 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcm6 35
  • 86.89 (n)
  • 96.1 (a)
chicken
(Gallus gallus)
Aves MCM6 35
  • 79.52 (n)
  • 88.21 (a)
MCM6 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCM6 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mcm6.2 35
  • 73.49 (n)
  • 82.84 (a)
zebrafish
(Danio rerio)
Actinopterygii mcm6 35
  • 72.24 (n)
  • 83.65 (a)
mcm6 36
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta MCM6_ANOGA 35
  • 60.95 (n)
  • 66.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mcm6 35
  • 60.94 (n)
  • 64.62 (a)
Mcm6 36
  • 64 (a)
OneToOne
Mcm6 37
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea mcm-6 36
  • 56 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCM6 36
  • 37 (a)
OneToOne
MCM6 38
barley
(Hordeum vulgare)
Liliopsida Hv.4310 35
wheat
(Triticum aestivum)
Liliopsida Ta.6297 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8378 36
  • 56 (a)
OneToOne
Species with no ortholog for MCM6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MCM6 Gene

ENSEMBL:
Gene Tree for MCM6 (if available)
TreeFam:
Gene Tree for MCM6 (if available)

Paralogs for MCM6 Gene

Selected SIMAP similar genes for MCM6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MCM6: view

No data available for Paralogs for MCM6 Gene

Variants for MCM6 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MCM6 Gene

Q14566-MCM6_HUMAN
Intronic variations in MCM6 upstream from the LCT gene are associated with adult-type hypolactasia [MIM:223100] leading to lactose intolerance, or with lactase persistance. Lactose intolerance is a normal physiological phenomenon caused by developmental down-regulation of lactase activity during childhood or early adulthood. A non-coding variation in MCM6 affects the transcriptional regulation of the LCT gene resulting in down-regulation of lactase activity. However, the majority of Northern Europeans and some African populations have the ability to maintain lactase activity and digest lactose throughout life (lactase persistence)

Sequence variations from dbSNP and Humsavar for MCM6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs11656 -- 135,840,481(+) CAGCT(A/T)CTGCT utr-variant-3-prime
rs160329 -- 135,860,235(+) tcatg(C/T)cattc intron-variant
rs182549 -- 135,859,184(+) CACCG(C/T)GCCCA intron-variant
rs188680 -- 135,873,419(+) CAGAA(A/G)TAAGA intron-variant
rs191079 -- 135,876,201(+) CCGCC(C/T)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCM6 Gene

Variant ID Type Subtype PubMed ID
esv2032582 CNV Deletion 18987734
esv2720865 CNV Deletion 23290073

Relevant External Links for MCM6 Gene

HapMap Linkage Disequilibrium report
MCM6

Disorders for MCM6 Gene

(1) OMIM Diseases for MCM6 Gene (601806)

(2) University of Copenhagen DISEASES for MCM6 Gene

(3) Novoseek inferred disease relationships for MCM6 Gene

Disease -log(P) Hits PubMed IDs
craniopharyngioma 58.8 5
retinoblastoma 24.4 1
tumors 7.2 7

Relevant External Links for MCM6

Genetic Association Database (GAD)
MCM6
Human Genome Epidemiology (HuGE) Navigator
MCM6
genes like me logo Genes that share disorders with MCM6: view

No data available for UniProtKB/Swiss-Prot for MCM6 Gene

Publications for MCM6 Gene

  1. Characterisation of a human homologue of a yeast cell division cycle gene, MCM6, located adjacent to the 5' end of the lactase gene on chromosome 2q21. (PMID: 8977093) Harvey C.B. … Swallow D.M. (FEBS Lett. 1996) 3 4 23
  2. Human protein MCM6 on HeLa cell chromatin. (PMID: 9516426) Holthoff H.P. … Knippers R. (J. Biol. Chem. 1998) 3 4 23
  3. Multiple rare variants as a cause of a common phenotype: several different lactase persistence associated alleles in a single ethnic group. (PMID: 19937006) Ingram C.J. … Swallow D.M. (J. Mol. Evol. 2009) 3 23 48
  4. Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability. (PMID: 20103649) Pires I.M. … Hammond E.M. (Cancer Res. 2010) 3 23
  5. [Expression of minichromosome maintenance protein 6 in craniopharyngioma and its correlation with prognosis]. (PMID: 17294730) Xu J.G. … Wang X.S. (Sichuan Da Xue Xue Bao Yi Xue Ban 2007) 3 23

Products for MCM6 Gene

Sources for MCM6 Gene

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