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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MCM5 Gene

protein-coding GIFtS: 68
GCID: GC22P035797

minichromosome maintenance complex component 5

(Previous names: minichromosome maintenance deficient (S. cerevisiae) 5...)
(Previous symbol: CDC46)

Explore 21 diseases affiliated with
MCM5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Minichromosome Maintenance Complex Component 5¹ ²		Minichromosome Maintenance Deficient (S. Cerevisiae) 5 (Cell Division Cycle 46)¹
CDC46¹ ² ³ ⁵		DNA Replication Licensing Factor MCM5²
P1-CDC46² ³		MCM5 Minichromosome Maintenance Deficient 5, Cell Division Cycle 46²
CDC46 Homolog² ³		Minichromosome Maintenance Deficient 5 (Cell Division Cycle 46)²
MCM5 Minichromosome Maintenance Deficient 5, Cell Division Cycle 46 (S. Cerevisiae)¹		EC 3.6.4.12³

External Ids:	HGNC: 6948¹	Entrez Gene: 4174²	Ensembl: ENSG00000100297⁷	OMIM: 602696⁵	UniProtKB: P33992³

ORGUL members:
	NONCODE:n342275

Export aliases for MCM5 gene to outside databases

Previous GC identifers: GC22P032492 GC22P034120 GC22P034126 GC22P018759

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MCM5:

The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein

involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding

proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the

transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MCM5_HUMAN, P33992

Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential

for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in

the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure

of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the

adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex

helicase activity (By similarity). Interacts with MCMBP

Gene Wiki entry for MCM5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MCM5 gene promoter:
CREB p53 Brachyury deltaCREB p300 ARP-1 AP-4 NF-Y
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MCM5 promoter sequence

Search SABiosciences Chromatin IP Primers for MCM5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCM5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q12.3 HGNC cytogenetic band: 22q13.1-q13.2

MCM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCM5 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P035797: view genomic region (about GC identifiers)

Start:	35,796,056 bp from pter	End:	35,820,495 bp from pter
Size:	24,440 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MCM5_HUMAN, P33992 (See protein sequence)

Recommended Name: DNA replication licensing factor MCM5

Size: 734 amino acids; 82286 Da

Subunit: Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order

MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (By simililarity)

Subcellular location: Nucleus

Miscellaneous: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric

complexes with unclear biological significance. The MCM2-7 hexamer is the proposed physiological active complex

Secondary accessions: O60785 Q14578 Q9BTJ4 Q9BWL8

Explore the universe of human proteins at neXtProt for MCM5: NX_P33992

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P33992

MCM5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006730.2

ENSEMBL proteins:

ENSP00000216122 ENSP00000412847 ENSP00000371441 ENSP00000406151 ENSP00000393977

ENSP00000408705

Reactome Protein details: P33992
Human Recombinant Protein Products:

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	Novus Biologicals MCM5 Protein Novus Biologicals MCM5 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MCM5

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	8751386
GO:0005654	nucleoplasm	TAS	--
GO:0042555	MCM complex	IDA	17296731

MCM5 for ontologies About GeneDecksing

MCM5 Antibody Products:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MCM5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MCM5 for domains About GeneDecksing

4 InterPro domains/families:

IPR018525 MCM_CS

IPR012340 NA-bd_OB-fold

IPR008048 MCM5

IPR001208 MCM_DNA-dep_ATPase

Graphical View of Domain Structure for InterPro Entry P33992

ProtoNet protein and cluster: P33992

2 Blocks protein families:

IPB001208 MCM family

IPB008048 Mini-chromosome maintenance (MCM) protein 5 signature

UniProtKB/Swiss-Prot: MCM5_HUMAN, P33992

Similarity: Belongs to the MCM family

Similarity: Contains 1 MCM domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MCM5_HUMAN, P33992

Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential

for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in

the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure

of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the

adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex

helicase activity (By similarity). Interacts with MCMBP

Catalytic activity: ATP + H(2)O = ADP + phosphate

Genatlas biochemistry entry for MCM5:

DNA replication licensing factor,cell division cycle 46 (CDC46) homolog,involved in an early step of DNA

replication,participating in the cell cycle control of genome duplication

Enzyme Number (IUBMB): EC 3.6.4.12¹

miRNA Products:		miRTarBase miRNAs that target MCM5: hsa-mir-885-5p (MIRT005462)

		OriGene 3'-UTR Clone: MCM5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCM5
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCM5 (see all 7) OriGene shRNA RFP: MCM5 OriGene siRNA: MCM5
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Gene Editing
Products:

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		GenScript: all cDNA clones in your preferred vector: MCM5 (NM_006739)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MCM5
		Search LifeMap BioReagents cell lines for MCM5

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM5

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0004386	helicase activity	IEA	--
GO:0005515	protein binding	IPI	19862764
GO:0005524	ATP binding	IEA	--

MCM5 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MCM5:

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/11 pathways (see all 11)
Assembly of the pre-replicative complex	0.77	M/G1 Transition	0.62
Switching of origins to a post-replicative state	0.70	Synthesis of DNA	0.51
Orc1 removal from chromatin	0.70	DNA Replication	0.49
Regulation of DNA replication	0.68	Cell Cycle Checkpoints	0.42

Cell cycle

	Cell cycle	1.00			G1 to S cell cycle control	0.38
	Cell cycle	0.57

Lagging Strand Synthesis

	DNA strand elongation	0.65			Unwinding of DNA	0.00
	DNA replication	0.56

Cell cycle_Start of DNA replication in early S phase

Cell cycle_Start of DNA replication in early S phase

1.00

Cell cycle Start of DNA replication in early S phase

0.98

Immune response_IFN gamma signaling pathway

Immune response_IFN gamma signaling pathway

1.00

Immune response IFN gamma signaling pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for MCM5

	Immune response IFN gamma signaling pathway
	Cell cycle Start of DNA replication in early S phase

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MCM5

	Cell Cycle Control of Chromosomal Replication
	JAK-STAT Pathway

2 GeneGo (Thomson Reuters) Pathways for MCM5

	Immune response IFN gamma signaling pathway
	Cell cycle Start of DNA replication in early S phase

4 BioSystems Pathways for MCM5

	Cell cycle
	G1 to S cell cycle control
	TNF-alpha/NF-kB Signaling Pathway
	DNA Replication

5/21 Reactome Pathways for MCM5 (see all 21)

	Activation of ATR in response to replication stress
	Mitotic G1-G1/S phases
	DNA Replication
	Removal of licensing factors from origins
	Cell Cycle

2 Kegg Pathways (Kegg details for MCM5):

	DNA replication
	Cell cycle

MCM5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MCM5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/266 Interacting proteins for MCM5 (P33992^{1, 2, 3} ENSP00000216122⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 266)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4B	P62805¹^,³	EBI-359410,EBI-302023 I2D: score=4
HIST1H4C	P62805¹^,³	EBI-359410,EBI-302023 I2D: score=4
HIST1H4D	P62805¹^,³	EBI-359410,EBI-302023 I2D: score=4
HIST1H4E	P62805¹^,³	EBI-359410,EBI-302023 I2D: score=4
HIST1H4F	P62805¹^,³	EBI-359410,EBI-302023 I2D: score=4

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000084	S phase of mitotic cell cycle	TAS	--
GO:0000216	M/G1 transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--

MCM5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MCM5
Search CenterWatch for drugs/clinical trials and news about MCM5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MCM5 gene:

NM_006739.3

Unigene Cluster for MCM5:

Minichromosome maintenance complex component 5

Hs.517582 [show with all ESTs]

Unigene Representative Sequence: NM_006739

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000216122(uc003anu.4 uc003anv.4) ENST00000451351 ENST00000382011(uc010gws.2)

ENST00000455261 ENST00000416905 ENST00000444778 ENST00000464908 ENST00000493076(uc003anw.1)

ENST00000493569 ENST00000465557

miRNA Products:		OriGene 3'-UTR Clone: MCM5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCM5
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MCM5
		SwitchGear 3'UTR luciferase reporter plasmid: MCM5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCM5 (see all 7) OriGene shRNA RFP: MCM5 OriGene siRNA: MCM5
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCM5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCM5 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MCM5 (NM_006739)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCM5

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCM5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCM5

Additional cDNA sequence:

AK122853.1 AK130620.1 AK223323.1 AK291136.1 AK298624.1 AK301121.1 AK308343.1 AK312533.1

BC000142.1 BC003656.2 CR456517.1 D83986.1 X74795.2

24/29 DOTS entries (see all 29):

DT.100770443 DT.446050 DT.95173303 DT.95173305 DT.100872975 DT.97863831 DT.91976107 DT.100033185

DT.100872972 DT.100872973 DT.100872964 DT.97861685 DT.100872950 DT.100872958 DT.120640757 DT.95173309

DT.100872954 DT.100872976 DT.95247108 DT.100035097 DT.100715682 DT.100803364 DT.100841239 DT.100872952

24/679 AceView cDNA sequences (see all 679):

CR611599 BM480184 AU125974 BU932111 BE739897 BQ440710 CF145728 BM787690

BQ219621 BU839453 BU850199 BQ957762 AL043003 BG767144 BG770644 BE390184

CF780654 CR612297 BE388446 BU179314 BQ222354 BU538182 BU845031 BG943162

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for MCM5 (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^
SP1:							-								-																		-				-		-
SP2:							-								-						-												-				-		-
SP3:																																					-		-
SP4:
SP5:							-

ExUns:	16	^	17	^	18	^	19	^	20a	·	20b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for MCM5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MCM5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACTCGCCCA

About this image
See MCM5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MCM5

SOURCE GeneReport for Unigene cluster: Hs.517582

SABiosciences Expression via Pathway-Focused PCR Array including MCM5:

Cell Cycle in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MCM5 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCM5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCM5 gene from 9/38 species (see all 38) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MCM5¹	minichromosome maintenance complex component 5	82.65(n) 88.15(a)		418058 NM_001006243.1 NP_001006243.1
lizard (Anolis carolinensis)	Reptilia	MCM5⁶	--	88(a)	1 ↔ 1	5(21501337-21521538)
African clawed frog (Xenopus laevis)	Amphibia	MGC68977²	hypothetical protein MGC68977	77.29(n)		BC059310.1
zebrafish (Danio rerio)	Actinopterygii	mcm5²	MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) less	77.5(n)		286747 BC044460.1
fruit fly (Drosophila melanogaster)	Insecta	Mcm5^{1 , 3}	pre-replicative complex formation and maintenance chromatin binding less³ Minichromosome maintenance 5¹	67(a)³ 67.12(n)¹ 69.51(a)¹		3 86C6³ 41296¹ NM_079584.3¹ NP_524308.2¹
worm (Caenorhabditis elegans)	Secernentea	mcm-5^{1 , 3}	CDC46³ Protein MCM-5¹	59(a)³ 58.91(n)¹ 63.71(a)¹		III(4360182-4363046)³ 175552¹ NM_065457.3¹ NP_497858.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	MCM5(YLR274W)⁴ MCM5¹	Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase less⁴ Mcm5p¹	51.27(n)¹ 51.04(a)¹		12(691555-693882)⁴ 850980^{1, 4} NP_013376.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	MCM5¹	minichromosome maintenance protein 5 (cell division control protein 46) less	51.16(n) 49.72(a)		815415 NM_126771.5 NP_178812.1
rice (Oryza sativa)	Liliopsida	Os02g0797400¹	hypothetical protein	55.65(n) 53.39(a)		4331016 NM_001054931.1 NP_001048396.1

ENSEMBL Gene Tree for MCM5 (if available)
TreeFam Gene Tree for MCM5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186959989^1,2		--	35794138(+)	`CAGGGG/TTTCAC`	1	--	us2k¹		0	--	--	--	--
rs190223109^1,2		--	35794318(+)	`ACTCCA/TGGGCT`	1	--	us2k¹		0	--	--	--	--
rs4821398^1,2	C,A,	--	35794409(+)	`TTTCAG/AGCCGG`	1	--	us2k¹		7		NA CSA WA EA	364
rs115706163^1,2	C,F,	--	35794724(+)	`GAAGCG/AGGATC`	1	--	us2k¹		1		WA	118
rs114202877^1,2		--	35794742(+)	`GTTGCC/GCAGGC`	1	--	us2k¹		1		WA	118
rs141970348^1,2		--	35794890(+)	`TTTGGG/TCAAGG`	1	--	us2k¹		0	--	--	--	--
rs112360469^1,2		--	35794973(+)	`CTCACG/CCCTGT`	1	--	us2k¹		1		CSA	2
rs139520240^1,2		--	35794993(+)	`ACTTTC/GGGAGG`	1	--	us2k¹		0	--	--	--	--
rs182612728^1,2		--	35795001(+)	`AGGCCA/GAAGCG`	1	--	us2k¹		0	--	--	--	--
rs115082792^1,2	F,	--	35795026(+)	`GGCCAG/AAAGTT`	1	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for MCM5 (35796056 - 35820495 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MCM5: --
Human Gene Mutation Database (HGMD): MCM5

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MCM5

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MCM5 for disorders           About GeneDecksing

OMIM gene information: 602696    OMIM disorders: --

20/21 diseases for MCM5 (see all 21):    About MalaCards

cervical intraepithelial neoplasia mantle cell lymphoma desmoid tumor chronic lymphocytic leukemia

lymphocytic leukemia fibromatosis squamous cell carcinoma skin disease

gastric adenocarcinoma cervicitis thyroid carcinoma cervical cancer

colon cancer thyroiditis leukemia adenocarcinoma

prostate cancer breast cancer carcinoma prostatitis

1 disease from the University of Copenhagen DISEASES database for MCM5:

Melanoacanthoma

1 Novoseek disease relationship for MCM5 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	14.6	4	15266314 (3)

Human Genome Epidemiology (HuGE) Navigator: MCM5 (3 documents)

Export disorders for MCM5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MCM5 gene, integrated from 9 sources (see all 96):
(articles sorted by number of sources associating them with MCM5)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2, 3} Dunham I....O'Brien K.P. (1999)
Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5. (PubMed id 8751386)^{1, 3, 9} Paul R....Knippers R. (1996)
The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins. (PubMed id 8265339)^{1, 2, 9} Hu B.... Knippers R. (1993)
Identification and characterization of a novel component of the human minichromosome maintenance complex. (PubMed id 17296731)^{1, 2} Sakwe A.M....Frappier L. (2007)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Expression of minichromosome maintenance 5 protein in proliferative and malignant skin diseases. (PubMed id 17988337)^{1, 9} Liu H....Tu Y. (2007)
Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma. (PubMed id 11248027)^{1, 9} DaFonseca C.J....Zhang J.J. (2001)
Clinical significance of MCM-2 and MCM-5 expression in colon cancer: association with clinicopathological parameters and tumor proliferative capacity. (PubMed id 18465232)^{1, 9} Giaginis C....Theocharis S. (2009)
Minichromosome maintenance proteins 2 and 5 in non-benign epithelial ovarian tumours: relationship with cell cycle regulators and prognostic implications. (PubMed id 17940502)^{1, 9} Gakiopoulou H....Patsouris E. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4174	HGNC: 6948	AceView: MCM5	Ensembl:ENSG00000100297	euGenes: HUgn4174
ECgene: MCM5	Kegg: 4174	H-InvDB: MCM5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MCM5	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MCM5	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mcm5/

Intellectual Property for MCM5 gene
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About This Section

Patent Information for MCM5 gene:
Search GeneIP for patents involving MCM5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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minichromosome maintenance complex component 5

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minichromosome maintenance complex component 5

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