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Aliases for MCM5 Gene

Aliases for MCM5 Gene

  • Minichromosome Maintenance Complex Component 5 2 3 5
  • CDC46 Homolog 3 4
  • P1-CDC46 3 4
  • CDC46 3 4
  • MCM5 Minichromosome Maintenance Deficient 5, Cell Division Cycle 46 (S. Cerevisiae) 2
  • Minichromosome Maintenance Deficient (S. Cerevisiae) 5 (Cell Division Cycle 46) 2
  • MCM5 Minichromosome Maintenance Deficient 5, Cell Division Cycle 46 3
  • Minichromosome Maintenance Deficient 5 (Cell Division Cycle 46) 3
  • EC 3.6.4.12 4

External Ids for MCM5 Gene

Previous HGNC Symbols for MCM5 Gene

  • CDC46

Previous GeneCards Identifiers for MCM5 Gene

  • GC22P032492
  • GC22P034120
  • GC22P034126
  • GC22P035797
  • GC22P018759
  • GC22P035798

Summaries for MCM5 Gene

Entrez Gene Summary for MCM5 Gene

  • The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for MCM5 Gene

MCM5 (Minichromosome Maintenance Complex Component 5) is a Protein Coding gene. Diseases associated with MCM5 include melanoacanthoma and anal squamous cell carcinoma. Among its related pathways are Cell cycle and DNA strand elongation. GO annotations related to this gene include chromatin binding and DNA replication origin binding.

UniProtKB/Swiss-Prot for MCM5 Gene

  • Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Interacts with MCMBP.

Gene Wiki entry for MCM5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCM5 Gene

Genomics for MCM5 Gene

Regulatory Elements for MCM5 Gene

Enhancers for MCM5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MCM5 on UCSC Golden Path with GeneCards custom track

Promoters for MCM5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MCM5 on UCSC Golden Path with GeneCards custom track

Genomic Location for MCM5 Gene

Chromosome:
22
Start:
35,400,063 bp from pter
End:
35,454,889 bp from pter
Size:
54,827 bases
Orientation:
Plus strand

Genomic View for MCM5 Gene

Genes around MCM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCM5 Gene

Proteins for MCM5 Gene

  • Protein details for MCM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33992-MCM5_HUMAN
    Recommended name:
    DNA replication licensing factor MCM5
    Protein Accession:
    P33992
    Secondary Accessions:
    • O60785
    • Q14578
    • Q9BTJ4
    • Q9BWL8

    Protein attributes for MCM5 Gene

    Size:
    734 amino acids
    Molecular mass:
    82286 Da
    Quaternary structure:
    • Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (Probable). Interacts with ANKRD17.
    Miscellaneous:
    • Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. The MCM2-7 hexamer is the proposed physiological active complex.

neXtProt entry for MCM5 Gene

Proteomics data for MCM5 Gene at MOPED

Post-translational modifications for MCM5 Gene

  • Ubiquitination at Lys 228, Lys 337, Lys 387, Lys 396, Lys 407, Lys 471, Lys 499, and Lys 627
  • Modification sites at PhosphoSitePlus

Other Protein References for MCM5 Gene

No data available for DME Specific Peptides for MCM5 Gene

Domains & Families for MCM5 Gene

Gene Families for MCM5 Gene

Graphical View of Domain Structure for InterPro Entry

P33992

UniProtKB/Swiss-Prot:

MCM5_HUMAN :
  • Contains 1 MCM domain.
  • Belongs to the MCM family.
Domain:
  • Contains 1 MCM domain.
Family:
  • Belongs to the MCM family.
genes like me logo Genes that share domains with MCM5: view

Function for MCM5 Gene

Molecular function for MCM5 Gene

GENATLAS Biochemistry:
DNA replication licensing factor,cell division cycle 46 (CDC46) homolog,involved in an early step of DNA replication,participating in the cell cycle control of genome duplication
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Interacts with MCMBP.

Enzyme Numbers (IUBMB) for MCM5 Gene

Gene Ontology (GO) - Molecular Function for MCM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003688 DNA replication origin binding IEA --
genes like me logo Genes that share ontologies with MCM5: view
genes like me logo Genes that share phenotypes with MCM5: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCM5 Gene

Localization for MCM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCM5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCM5 Gene COMPARTMENTS Subcellular localization image for MCM5 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for MCM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with MCM5: view

Pathways & Interactions for MCM5 Gene

genes like me logo Genes that share pathways with MCM5: view

Gene Ontology (GO) - Biological Process for MCM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0006270 DNA replication initiation IEA --
GO:0006271 DNA strand elongation involved in DNA replication TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with MCM5: view

No data available for SIGNOR curated interactions for MCM5 Gene

Drugs & Compounds for MCM5 Gene

(1) Drugs for MCM5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for MCM5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with MCM5: view

Transcripts for MCM5 Gene

Unigene Clusters for MCM5 Gene

Minichromosome maintenance complex component 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MCM5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^
SP1: - - - - -
SP2: - - - - - -
SP3: - -
SP4:
SP5: -
SP6: - - - -
SP7:
SP8: -
SP9: - - - - - - - - - - - - -
SP10: -

ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for MCM5 Gene

GeneLoc Exon Structure for
MCM5
ECgene alternative splicing isoforms for
MCM5

Expression for MCM5 Gene

mRNA expression in normal human tissues for MCM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MCM5 Gene

This gene is overexpressed in Liver (35.2) and Breast (23.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCM5 Gene



SOURCE GeneReport for Unigene cluster for MCM5 Gene Hs.517582

genes like me logo Genes that share expression patterns with MCM5: view

Protein tissue co-expression partners for MCM5 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MCM5 Gene

Orthologs for MCM5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCM5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MCM5 35
  • 91.92 (n)
  • 96.87 (a)
MCM5 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCM5 35
  • 91.95 (n)
  • 97.94 (a)
MCM5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcm5 35
  • 88.24 (n)
  • 95.64 (a)
Mcm5 16
Mcm5 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MCM5 35
  • 99.55 (n)
  • 99.59 (a)
MCM5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcm5 35
  • 87.64 (n)
  • 96.91 (a)
oppossum
(Monodelphis domestica)
Mammalia MCM5 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCM5 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves MCM5 35
  • 82.65 (n)
  • 88.15 (a)
MCM5 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCM5 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mcm5 35
  • 75.43 (n)
  • 86.78 (a)
Str.332 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68977 35
zebrafish
(Danio rerio)
Actinopterygii mcm5 35
  • 73.12 (n)
  • 80.52 (a)
mcm5 36
  • 80 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13677 35
fruit fly
(Drosophila melanogaster)
Insecta Mcm5 37
  • 67 (a)
Mcm5 35
  • 67.12 (n)
  • 69.51 (a)
Mcm5 36
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004408 35
  • 65.84 (n)
  • 69.55 (a)
worm
(Caenorhabditis elegans)
Secernentea mcm-5 37
  • 59 (a)
mcm-5 35
  • 58.91 (n)
  • 63.71 (a)
mcm-5 36
  • 60 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR276W 35
  • 57.32 (n)
  • 50.7 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09262g 35
  • 52.04 (n)
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCM5 35
  • 51.32 (n)
  • 51.04 (a)
MCM5 36
  • 47 (a)
OneToOne
MCM5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons MCM5 35
  • 51.49 (n)
  • 49.86 (a)
soybean
(Glycine max)
eudicotyledons Gma.11296 35
barley
(Hordeum vulgare)
Liliopsida Hv.2648 35
rice
(Oryza sativa)
Liliopsida Os02g0797400 35
  • 55.65 (n)
  • 53.39 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.3618 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13790 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01171 35
  • 57.85 (n)
  • 51.34 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mcm5 35
  • 50.78 (n)
  • 49.65 (a)
Species with no ortholog for MCM5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MCM5 Gene

ENSEMBL:
Gene Tree for MCM5 (if available)
TreeFam:
Gene Tree for MCM5 (if available)

Paralogs for MCM5 Gene

(4) SIMAP similar genes for MCM5 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MCM5: view

No data available for Paralogs for MCM5 Gene

Variants for MCM5 Gene

Sequence variations from dbSNP and Humsavar for MCM5 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs2307334 - 35,403,526(+) TTCCA(C/G)CATTC reference, missense
rs2307340 - 35,406,668(+) CCTCA(C/G)CAACA reference, missense
rs2230933 - 35,410,763(+) AGGTC(A/C/G)TCCCT reference, missense
rs80433 -- 35,414,059(+) GGTCC(C/T)CAGGA intron-variant
rs133414 -- 35,409,727(+) GAGAG(A/C/T)GGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCM5 Gene

Variant ID Type Subtype PubMed ID
nsv914994 CNV Loss 21882294
nsv914995 CNV Loss 21882294
nsv914996 CNV Loss 21882294
nsv520686 CNV Loss 19592680

Variation tolerance for MCM5 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCM5 Gene

HapMap Linkage Disequilibrium report
MCM5
Human Gene Mutation Database (HGMD)
MCM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCM5 Gene

Disorders for MCM5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MCM5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
melanoacanthoma
anal squamous cell carcinoma
  • carcinoma of anal margin
desmoid tumor
  • desmoid disease, hereditary
- elite association - COSMIC cancer census association via MalaCards
Search MCM5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MCM5

Genetic Association Database (GAD)
MCM5
Human Genome Epidemiology (HuGE) Navigator
MCM5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCM5
genes like me logo Genes that share disorders with MCM5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MCM5 Gene

Publications for MCM5 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4 67
  2. Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5. (PMID: 8751386) Paul R. … Knippers R. (Cytogenet. Cell Genet. 1996) 2 3 23
  3. Clinical significance of MCM-2 and MCM-5 expression in colon cancer: association with clinicopathological parameters and tumor proliferative capacity. (PMID: 18465232) Giaginis C. … Theocharis S. (Dig. Dis. Sci. 2009) 3 23
  4. Cyclin E-dependent localization of MCM5 regulates centrosome duplication. (PMID: 18799789) Ferguson R.L. … Maller J.L. (J. Cell. Sci. 2008) 3 23
  5. Minichromosome maintenance proteins 2 and 5 in non-benign epithelial ovarian tumours: relationship with cell cycle regulators and prognostic implications. (PMID: 17940502) Gakiopoulou H. … Patsouris E. (Br. J. Cancer 2007) 3 23

Products for MCM5 Gene

Sources for MCM5 Gene

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