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Aliases for MCM5 Gene

Aliases for MCM5 Gene

  • Minichromosome Maintenance Complex Component 5 2 3
  • CDC46 3 4 6
  • CDC46 Homolog 3 4
  • P1-CDC46 3 4
  • MCM5 Minichromosome Maintenance Deficient 5, Cell Division Cycle 46 (S. Cerevisiae) 2
  • Minichromosome Maintenance Deficient (S. Cerevisiae) 5 (Cell Division Cycle 46) 2
  • MCM5 Minichromosome Maintenance Deficient 5, Cell Division Cycle 46 3
  • Minichromosome Maintenance Deficient 5 (Cell Division Cycle 46) 3
  • DNA Replication Licensing Factor MCM5 3
  • EC 3.6.4.12 4

External Ids for MCM5 Gene

Previous HGNC Symbols for MCM5 Gene

  • CDC46

Previous GeneCards Identifiers for MCM5 Gene

  • GC22P032492
  • GC22P034120
  • GC22P034126
  • GC22P035797
  • GC22P018759
  • GC22P035798

Summaries for MCM5 Gene

Entrez Gene Summary for MCM5 Gene

  • The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for MCM5 Gene

MCM5 (Minichromosome Maintenance Complex Component 5) is a Protein Coding gene. Diseases associated with MCM5 include melanoacanthoma. Among its related pathways are TGF-Beta Pathway and Cell Cycle, Mitotic. GO annotations related to this gene include DNA helicase activity.

UniProtKB/Swiss-Prot for MCM5 Gene

  • Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Interacts with MCMBP.

Gene Wiki entry for MCM5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCM5 Gene

Genomics for MCM5 Gene

Regulatory Elements for MCM5 Gene

Genomic Location for MCM5 Gene

Start:
35,400,063 bp from pter
End:
35,454,094 bp from pter
Size:
54,032 bases
Orientation:
Plus strand

Genomic View for MCM5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCM5 Gene

Proteins for MCM5 Gene

  • Protein details for MCM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33992-MCM5_HUMAN
    Recommended name:
    DNA replication licensing factor MCM5
    Protein Accession:
    P33992
    Secondary Accessions:
    • O60785
    • Q14578
    • Q9BTJ4
    • Q9BWL8

    Protein attributes for MCM5 Gene

    Size:
    734 amino acids
    Molecular mass:
    82286 Da
    Quaternary structure:
    • Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (By simililarity). Interacts with ANKRD17.
    Miscellaneous:
    • Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. The MCM2-7 hexamer is the proposed physiological active complex

neXtProt entry for MCM5 Gene

Proteomics data for MCM5 Gene at MOPED

Post-translational modifications for MCM5 Gene

  • Ubiquitination at Lys228, Lys337, Lys387, Lys396, Lys407, Lys471, Lys499, Lys627, and Lys696
  • Modification sites at PhosphoSitePlus

Other Protein References for MCM5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MCM5 Gene

Domains for MCM5 Gene

Graphical View of Domain Structure for InterPro Entry

P33992

UniProtKB/Swiss-Prot:

MCM5_HUMAN :
  • P33992
Domain:
  • Contains 1 MCM domain.
Family:
  • Belongs to the MCM family.
genes like me logo Genes that share domains with MCM5: view

No data available for Gene Families for MCM5 Gene

Function for MCM5 Gene

Molecular function for MCM5 Gene

GENATLAS Biochemistry: DNA replication licensing factor,cell division cycle 46 (CDC46) homolog,involved in an early step of DNA replication,participating in the cell cycle control of genome duplication
UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Interacts with MCMBP.

Enzyme Numbers (IUBMB) for MCM5 Gene

Gene Ontology (GO) - Molecular Function for MCM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003678 DNA helicase activity IEA --
GO:0003682 chromatin binding IEA --
GO:0003688 DNA replication origin binding IEA --
GO:0005515 protein binding IPI 12364596
genes like me logo Genes that share ontologies with MCM5: view

Phenotypes for MCM5 Gene

GenomeRNAi human phenotypes for MCM5:
genes like me logo Genes that share phenotypes with MCM5: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MCM5 Gene

Localization for MCM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCM5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCM5 Gene COMPARTMENTS Subcellular localization image for MCM5 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for MCM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8751386
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IDA 19946888
GO:0042555 MCM complex IDA 17296731
genes like me logo Genes that share ontologies with MCM5: view

Pathways for MCM5 Gene

genes like me logo Genes that share pathways with MCM5: view

Gene Ontology (GO) - Biological Process for MCM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006260 DNA replication TAS --
GO:0006270 DNA replication initiation IEA --
GO:0006271 DNA strand elongation involved in DNA replication TAS --
genes like me logo Genes that share ontologies with MCM5: view

Transcripts for MCM5 Gene

Unigene Clusters for MCM5 Gene

Minichromosome maintenance complex component 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MCM5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^
SP1: - - - - -
SP2: - - - - - -
SP3: - -
SP4:
SP5: -
SP6: - - - -
SP7:
SP8: -
SP9: - - - - - - - - - - - - -
SP10: -

ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for MCM5 Gene

GeneLoc Exon Structure for
MCM5
ECgene alternative splicing isoforms for
MCM5

Expression for MCM5 Gene

mRNA expression in normal human tissues for MCM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCM5 Gene

SOURCE GeneReport for Unigene cluster for MCM5 Gene Hs.517582

genes like me logo Genes that share expressions with MCM5: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MCM5 Gene

Orthologs for MCM5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCM5 35
  • 99.55 (n)
  • 99.59 (a)
MCM5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MCM5 35
  • 91.92 (n)
  • 96.87 (a)
MCM5 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCM5 35
  • 91.95 (n)
  • 97.94 (a)
MCM5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcm5 35
  • 88.24 (n)
  • 95.64 (a)
Mcm5 16
Mcm5 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCM5 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCM5 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcm5 35
  • 87.64 (n)
  • 96.91 (a)
chicken
(Gallus gallus)
Aves MCM5 35
  • 82.65 (n)
  • 88.15 (a)
MCM5 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCM5 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68977 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mcm5 35
  • 75.43 (n)
  • 86.78 (a)
Str.332 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13677 35
zebrafish
(Danio rerio)
Actinopterygii mcm5 35
  • 73.12 (n)
  • 80.52 (a)
mcm5 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004408 35
  • 65.84 (n)
  • 69.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mcm5 35
  • 67.12 (n)
  • 69.51 (a)
Mcm5 36
  • 68 (a)
OneToOne
Mcm5 37
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea mcm-5 35
  • 58.91 (n)
  • 63.71 (a)
mcm-5 36
  • 60 (a)
OneToOne
mcm-5 37
  • 59 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR276W 35
  • 57.32 (n)
  • 50.7 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCM5 35
  • 51.32 (n)
  • 51.04 (a)
MCM5 36
  • 47 (a)
OneToOne
MCM5 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09262g 35
  • 52.04 (n)
  • 50 (a)
soybean
(Glycine max)
eudicotyledons Gma.11296 35
thale cress
(Arabidopsis thaliana)
eudicotyledons MCM5 35
  • 51.49 (n)
  • 49.86 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2648 35
rice
(Oryza sativa)
Liliopsida Os02g0797400 35
  • 55.65 (n)
  • 53.39 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.3618 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01171 35
  • 57.85 (n)
  • 51.34 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mcm5 35
  • 50.78 (n)
  • 49.65 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13790 35
Species with no ortholog for MCM5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MCM5 Gene

ENSEMBL:
Gene Tree for MCM5 (if available)
TreeFam:
Gene Tree for MCM5 (if available)

Paralogs for MCM5 Gene

Selected SIMAP similar genes for MCM5 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MCM5: view

No data available for Paralogs for MCM5 Gene

Variants for MCM5 Gene

Sequence variations from dbSNP and Humsavar for MCM5 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs80433 -- 35,414,059(+) GGTCC(C/T)CAGGA intron-variant
rs133414 -- 35,409,727(+) GAGAG(A/C/T)GGATC intron-variant
rs133415 -- 35,410,245(+) ATTTT(G/T)AAAAC intron-variant
rs133416 -- 35,410,383(+) CACAG(C/T)GAGCT intron-variant
rs133417 -- 35,410,822(+) CTGAC(C/T)ACCAG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for MCM5 Gene

Variant ID Type Subtype PubMed ID
nsv914994 CNV Loss 21882294
nsv914995 CNV Loss 21882294
nsv914996 CNV Loss 21882294
nsv520686 CNV Loss 19592680

Relevant External Links for MCM5 Gene

HapMap Linkage Disequilibrium report
MCM5
Human Gene Mutation Database (HGMD)
MCM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCM5 Gene

Disorders for MCM5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MCM5 Gene including...

Search for MCM5 Gene in MalaCards »

(1) University of Copenhagen DISEASES for MCM5 Gene

(1) Novoseek inferred disease relationships for MCM5 Gene

Disease -log(P) Hits PubMed IDs
cancer 14.6 3

Relevant External Links for MCM5

Genetic Association Database (GAD)
MCM5
Human Genome Epidemiology (HuGE) Navigator
MCM5
genes like me logo Genes that share disorders with MCM5: view

No data available for UniProtKB/Swiss-Prot for MCM5 Gene

Publications for MCM5 Gene

  1. The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins. (PMID: 8265339) Hu B. … Knippers R. (Nucleic Acids Res. 1993) 3 4 23
  2. Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5. (PMID: 8751386) Paul R. … Knippers R. (Cytogenet. Cell Genet. 1996) 2 3 23
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4
  4. Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation. (PMID: 9843502) Zhang J.J. … Darnell J.E. (EMBO J. 1998) 3 23
  5. Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F. (PMID: 10327050) Ohtani K. … Nojima H. (Oncogene 1999) 3 23

Products for MCM5 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cell Cycle in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MCM5
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MCM5
    • Block miRNA regulation of MCM5 using miScript Target Protectors

    Sources for MCM5 Gene

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