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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MCM5 Gene

protein-coding   GIFtS: 70
GCID: GC22P035798

Minichromosome Maintenance Complex Component 5

(Previous names: minichromosome maintenance deficient (S. cerevisiae) 5 (cell...)
(Previous symbol: CDC46)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Minichromosome Maintenance Complex Component 51 2     Minichromosome Maintenance Deficient (S. Cerevisiae) 5 (Cell Division
Cycle 46)1
CDC461 2 3 5     DNA Replication Licensing Factor MCM52
P1-CDC462 3     MCM5 Minichromosome Maintenance Deficient 5, Cell Division Cycle 462
CDC46 Homolog2 3     Minichromosome Maintenance Deficient 5 (Cell Division Cycle 46)2
MCM5 Minichromosome Maintenance Deficient 5, Cell Division Cycle 46 (S.
Cerevisiae)1
     EC 3.6.4.123

External Ids:    HGNC: 69481   Entrez Gene: 41742   Ensembl: ENSG000001002977   OMIM: 6026965   UniProtKB: P339923   

Export aliases for MCM5 gene to outside databases

Previous GC identifers: GC22P032492 GC22P034120 GC22P034126 GC22P035797 GC22P018759


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MCM5 Gene:
The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein
involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of
chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein
is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell
cycle regulation. (provided by RefSeq, Jul 2008)

GeneCards Summary for MCM5 Gene: 
MCM5 (minichromosome maintenance complex component 5) is a protein-coding gene. Diseases associated with MCM5 include melanoacanthoma, and desmoid tumor, and among its related super-pathways are Activation of the pre-replicative complex and Lagging Strand Synthesis. GO annotations related to this gene include helicase activity and ATP binding.

UniProtKB/Swiss-Prot: MCM5_HUMAN, P33992
Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase
essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active
ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that
a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site
of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute
differentially to the complex helicase activity (By similarity). Interacts with MCMBP

Gene Wiki entry for MCM5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MCM5 gene promoter:
         CREB   p53   Brachyury   deltaCREB   p300   ARP-1   AP-4   NF-Y   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMCM5 promoter sequence
   Search SABiosciences Chromatin IP Primers for MCM5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q13.1-q13.2

MCM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCM5 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P035798:  view genomic region     (about GC identifiers)

Start:
35,796,056 bp from pter      End:
35,821,423 bp from pter
Size:
25,368 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MCM5_HUMAN, P33992 (See protein sequence)
Recommended Name: DNA replication licensing factor MCM5  
Size: 734 amino acids; 82286 Da
Subunit: Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit
order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (By simililarity)
Subcellular location: Nucleus
Miscellaneous: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and
tetrameric complexes with unclear biological significance. The MCM2-7 hexamer is the proposed physiological
active complex
Secondary accessions: O60785 Q14578 Q9BTJ4 Q9BWL8

Explore the universe of human proteins at neXtProt for MCM5: NX_P33992

Explore proteomics data for MCM5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P33992

  • MCM5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MCM5 Protein Expression
    REFSEQ proteins: NP_006730.2  
    ENSEMBL proteins: 
     ENSP00000216122   ENSP00000412847   ENSP00000371441   ENSP00000393977   ENSP00000408705  
    Reactome Protein details: P33992
    Human Recombinant Protein Products for MCM5: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MCM5 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS8751386
    GO:0005654nucleoplasm TAS--
    GO:0042555MCM complex IDA17296731

    MCM5 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for MCM5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR018525 MCM_CS
     IPR012340 NA-bd_OB-fold
     IPR008048 MCM5
     IPR027417 P-loop_NTPase
     IPR001208 MCM_DNA-dep_ATPase

    Graphical View of Domain Structure for InterPro Entry P33992

    ProtoNet protein and cluster: P33992

    2 Blocks protein domains:
    IPB001208 MCM family
    IPB008048 Mini-chromosome maintenance (MCM) protein 5 signature


    UniProtKB/Swiss-Prot: MCM5_HUMAN, P33992
    Similarity: Belongs to the MCM family
    Similarity: Contains 1 MCM domain


    MCM5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MCM5_HUMAN, P33992
    Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase
    essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active
    ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that
    a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site
    of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute
    differentially to the complex helicase activity (By similarity). Interacts with MCMBP
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Genatlas biochemistry entry for MCM5:
    DNA replication licensing factor,cell division cycle 46 (CDC46) homolog,involved in an early step of DNA
    replication,participating in the cell cycle control of genome duplication

         Enzyme Number (IUBMB): EC 3.6.4.121

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003678DNA helicase activity IEA--
    GO:0005515protein binding IPI12364596
    GO:0005524ATP binding IEA--
         
    MCM5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MCM5:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MCM5 
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    miRNA
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    miRTarBase miRNAs that target MCM5:
    hsa-mir-885-5p (MIRT005462)

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MCM5 About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Activation of the pre-replicative complex
    Activation of the pre-replicative complex0.67
    Cell cycle Start of DNA replication in early S phase0.54
    DNA Replication0.67
    2Lagging Strand Synthesis
    DNA strand elongation0.65
    Unwinding of DNA0.35
    DNA replication0.63
    3Mitotic G1-G1/S phases
    Mitotic G1-G1/S phases0.80
    G1 to S cell cycle control0.36
    G1/S Transition0.80
    4Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    5CDK-mediated phosphorylation and removal of Cdc6
    Assembly of the pre-replicative complex0.91
    DNA Replication Pre-Initiation0.81
    Removal of licensing factors from origins0.89
    Synthesis of DNA0.79
    Regulation of DNA replication0.89
    S Phase0.79
    Orc1 removal from chromatin0.89
    DNA Replication0.78

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for MCM5
        Immune response IFN gamma signaling pathway
    Cell cycle Start of DNA replication in early S phase

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MCM5
        Cell Cycle Control of Chromosomal Replication
    JAK-STAT Pathway

    2 GeneGo (Thomson Reuters) Pathways for MCM5
        Immune response IFN gamma signaling pathway
    Cell cycle Start of DNA replication in early S phase

    4 BioSystems Pathways for MCM5
        Cell cycle
    G1 to S cell cycle control
    DNA Replication
    TNF-alpha/NF-kB Signaling Pathway

    5/21        Reactome Pathways for MCM5 (see all 21)
        Activation of ATR in response to replication stress
    Mitotic G1-G1/S phases
    DNA Replication
    Removal of licensing factors from origins
    Cell Cycle


    2         Kegg Pathways  (Kegg details for MCM5):
        DNA replication
    Cell cycle


    MCM5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MCM5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/275 Interacting proteins for MCM5 (P339921, 2, 3 ENSP000002161224) via UniProtKB, MINT, STRING, and/or I2D (see all 275)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4BP628051, 3EBI-359410,EBI-302023 I2D: score=4 
    HIST1H4CP628051, 3EBI-359410,EBI-302023 I2D: score=4 
    HIST1H4DP628051, 3EBI-359410,EBI-302023 I2D: score=4 
    HIST1H4EP628051, 3EBI-359410,EBI-302023 I2D: score=4 
    HIST1H4FP628051, 3EBI-359410,EBI-302023 I2D: score=4 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006260DNA replication TAS--
    GO:0006270DNA replication initiation IEA--
    GO:0006271DNA strand elongation involved in DNA replication TAS--

    MCM5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MCM5

    Search CenterWatch for drugs/clinical trials and news about MCM5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MCM5 gene: 
    NM_006739.3  

    Unigene Cluster for MCM5:

    Minichromosome maintenance complex component 5
    Hs.517582  [show with all ESTs]
    Unigene Representative Sequence: NM_006739
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216122(uc003anu.4 uc003anv.4) ENST00000451351 ENST00000382011(uc010gws.2)
    ENST00000416905 ENST00000444778 ENST00000464908 ENST00000493076(uc003anw.1)
    ENST00000493569 ENST00000465557
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCM5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCM5

    Additional mRNA sequence: 

    AK122853.1 AK130620.1 AK223323.1 AK291136.1 AK298624.1 AK301121.1 AK308343.1 AK312533.1 
    BC000142.1 BC003656.2 CR456517.1 D83986.1 X74795.2 

    24/29 DOTS entries (see all 29):

    DT.100770443  DT.446050  DT.95173303  DT.95173305  DT.100872975  DT.97863831  DT.91976107  DT.100033185 
    DT.100872972  DT.100872973  DT.100872964  DT.97861685  DT.100872950  DT.100872958  DT.120640757  DT.95173309 
    DT.100872954  DT.100872976  DT.95247108  DT.100035097  DT.100715682  DT.100803364  DT.100841239  DT.100872952 

    24/679 AceView cDNA sequences (see all 679):

    BM927583 AA355052 BU195081 AA749315 BU845031 AA909417 BQ772212 BE253723 
    BU556785 BU850199 BM835685 AA768055 BU166135 BQ083137 AA360084 BM470663 
    BQ887166 AL043003 BQ895922 AU121855 CR611599 BM846378 AU131148 NM_006739 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for MCM5 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^
    SP1:                    -                       -                                                     -           -     -                                       
    SP2:                    -                       -                 -                                   -           -     -                                       
    SP3:                                                                                                              -     -                                       
    SP4:                                                                                                                                                            
    SP5:                    -                                                                                                                                       

    ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for MCM5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MCM5 expression in normal human tissues (normalized intensities)      MCM5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTCGCCCA
    MCM5 Expression
    About this image


    MCM5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
             Olfactory Bulb   
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             nasopharynx ; respiratory epithelial cells   
             sensory organ/nose/nasal cavity   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             cd34+ cells   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon

    See MCM5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MCM5

    SOURCE GeneReport for Unigene cluster: Hs.517582
        SABiosciences Expression via Pathway-Focused PCR Array including MCM5: 
              Cell Cycle in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MCM5 gene from 10/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mcm51 , 5 minichromosome maintenance deficient 5, cell division more1, 5 88.24(n)1
    95.64(a)1
      8 (35.59 cM)5
    172181  NM_008566.21  NP_032592.21 
     751095285 
    chicken
    (Gallus gallus)
    Aves MCM51 minichromosome maintenance complex component 5 82.65(n)
    88.15(a)
      418058  NM_001006243.1  NP_001006243.1 
    lizard
    (Anolis carolinensis)
    Reptilia MCM56
    Uncharacterized protein
    88(a)
    1 ↔ 1
    5(21498897-21522534)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC689772 hypothetical protein MGC68977 77.29(n)    BC059310.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mcm52 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 77.5(n)   286747  BC044460.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mcm51 , 3 pre-replicative complex formation and
    maintenance more3
    Minichromosome maintenance 51
    67(a)3
    67.12(n)1
    69.51(a)1
      3 86C63
    412961  NM_079584.31  NP_524308.21 
    worm
    (Caenorhabditis elegans)
    Secernentea mcm-51 , 3 CDC463
    Protein MCM-51
    59(a)3
    58.91(n)1
    63.71(a)1
      III(4360182-4363046)3
    1755521  NM_065457.31  NP_497858.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MCM5(YLR274W)4
    MCM51
    Component of the hexameric MCM complex, which is important more4
    Mcm5p1
    51.27(n)1
    51.04(a)1
      12(691555-693882)4
    8509801, 4  NP_013376.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MCM51 minichromosome maintenance protein 5 (cell division more 51.16(n)
    49.72(a)
      815415  NM_126771.5  NP_178812.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g07974001 hypothetical protein 55.65(n)
    53.39(a)
      4331016  NM_001054931.1  NP_001048396.1 


    ENSEMBL Gene Tree for MCM5 (if available)
    TreeFam Gene Tree for MCM5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MCM5 gene
    4 SIMAP similar genes for MCM5 using alignment to 6 protein entries:     MCM5_HUMAN (see all proteins):
    FLJ00323    MCM7    MCM6    MCM4

    MCM5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/746 SNPs in MCM5 are shown (see all 746)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1869599891,2
    --35794138(+) CAGGGG/TTTCAC 1 -- us2k10--------
    rs1902231091,2
    --35794318(+) ACTCCA/TGGGCT 1 -- us2k10--------
    rs48213981,2
    C,A--35794409(+) tttcaG/Agccgg 1 -- us2k17Minor allele frequency- A:0.44NA CSA WA EA 364
    rs1157061631,2
    C,F--35794724(+) GAAGCG/AGGATC 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1142028771,2
    F--35794742(+) GTTGCC/GCAGGC 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1419703481,2
    --35794890(+) TTTGGG/TCAAGG 1 -- us2k10--------
    rs1123604691,2
    C,F--35794973(+) CTCACG/CCCTGT 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs1395202401,2
    --35794993(+) ACTTTC/GGGAGG 1 -- us2k10--------
    rs1826127281,2
    --35795001(+) AGGCCA/GAAGCG 1 -- us2k10--------
    rs1150827921,2
    C,F--35795026(+) GGCCAG/AAAGTT 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for MCM5 (35796056 - 35821423 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MCM5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv520686CNV Loss19592680
    nsv914995CNV Loss21882294
    nsv914996CNV Loss21882294
    nsv914994CNV Loss21882294


    Human Gene Mutation Database (HGMD): MCM5
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602696    OMIM disorders: --

    19 diseases for MCM5:    About MalaCards
    melanoacanthoma    desmoid tumor    fibromatosis    cervical intraepithelial neoplasia
    mantle cell lymphoma    gastric adenocarcinoma    skin disease    cervicitis
    chronic lymphocytic leukemia    cervical cancer    thyroiditis    colon cancer
    adenocarcinoma    squamous cell carcinoma    prostate cancer    gastric cancer
    leukemia    prostatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for MCM5:
    Melanoacanthoma

    MCM5 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for MCM5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 14.6 4 15266314 (3)

    Genetic Association Database (GAD): MCM5
    Human Genome Epidemiology (HuGE) Navigator: MCM5 (3 documents)

    Export disorders for MCM5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MCM5 gene, integrated from 9 sources (see all 107):
    (articles sorted by number of sources associating them with MCM5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I....O'Brien K.P. (1999)
    2. Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5. (PubMed id 8751386)1, 3, 9 Paul R....Knippers R. (1996)
    3. The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins. (PubMed id 8265339)1, 2, 9 Hu B.... Knippers R. (1993)
    4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    5. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (2008)
    6. Identification and characterization of a novel component of the human minichromosome maintenance complex. (PubMed id 17296731)1, 2 Sakwe A.M....Frappier L. (2007)
    7. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Expression of minichromosome maintenance 5 protein in proliferative and malignant skin diseases. (PubMed id 17988337)1, 9 Liu H....Tu Y. (2007)
    10. Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma. (PubMed id 11248027)1, 9 DaFonseca C.J....Zhang J.J. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4174 HGNC: 6948 AceView: MCM5 Ensembl:ENSG00000100297 euGenes: HUgn4174
    ECgene: MCM5 Kegg: 4174 H-InvDB: MCM5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MCM5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MCM5 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mcm5/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MCM5 gene:
    Search GeneIP for patents involving MCM5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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