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Aliases for MCM4 Gene

Aliases for MCM4 Gene

  • Minichromosome Maintenance Complex Component 4 2 3
  • CDC21 Homolog 3 4
  • P1-CDC21 3 4
  • CDC21 3 4
  • NKGCD 3 6
  • NKCD 3 6
  • MCM4 Minichromosome Maintenance Deficient 4 (S. Cerevisiae) 2
  • Homolog Of S. Pombe Cell Devision Cycle 21 3
  • Minichromosome Maintenance Deficient 4 3
  • DNA Replication Licensing Factor MCM4 3
  • EC 3.6.4.12 4
  • HCdc21 3
  • CDC54 3

External Ids for MCM4 Gene

Previous Symbols for MCM4 Gene

  • CDC21

Summaries for MCM4 Gene

Entrez Gene Summary for MCM4 Gene

  • The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for MCM4 Gene

MCM4 (Minichromosome Maintenance Complex Component 4) is a Protein Coding gene. Diseases associated with MCM4 include natural killer cell and glucocorticoid deficiency with dna repair defect and immunodeficiency with natural-killer cell deficiency and adrenal insufficiency. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include single-stranded DNA binding and ATP-dependent DNA helicase activity. An important paralog of this gene is MCM8.

UniProtKB/Swiss-Prot for MCM4 Gene

  • Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

Gene Wiki entry for MCM4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCM4 Gene

Genomics for MCM4 Gene

Genomic Location for MCM4 Gene

Start:
47,960,185 bp from pter
End:
47,978,160 bp from pter
Size:
17,976 bases
Orientation:
Plus strand

Genomic View for MCM4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCM4 Gene

Regulatory Elements for MCM4 Gene

Proteins for MCM4 Gene

  • Protein details for MCM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33991-MCM4_HUMAN
    Recommended name:
    DNA replication licensing factor MCM4
    Protein Accession:
    P33991
    Secondary Accessions:
    • Q8NEH1
    • Q99658

    Protein attributes for MCM4 Gene

    Size:
    863 amino acids
    Molecular mass:
    96558 Da
    Quaternary structure:
    • Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (By simililarity). Interacts with MCMBP.
    Miscellaneous:
    • Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex

neXtProt entry for MCM4 Gene

Proteomics data for MCM4 Gene at MOPED

Post-translational modifications for MCM4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys123, Lys163, Lys179, Lys216, Lys220, Lys349, Lys381, Lys439, Lys444, Lys450, Lys536, Lys600, Lys628, Lys752, Lys762, Lys770, Lys814, Lys819, and Lys858

Other Protein References for MCM4 Gene

No data available for DME Specific Peptides for MCM4 Gene

Domains for MCM4 Gene

UniProtKB/Swiss-Prot:

MCM4_HUMAN
Domain:
  • Contains 1 MCM domain.:
    • P33991
Family:
  • Belongs to the MCM family.:
    • P33991
genes like me logo Genes that share domains with MCM4: view

No data available for Gene Families for MCM4 Gene

Function for MCM4 Gene

Molecular function for MCM4 Gene

GENATLAS Biochemistry: cell division cycle 21(CDC21) homolog,involved in an early step of DNA replication,participating in the cell cycle control of genome duplication
UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

Enzyme Numbers (IUBMB) for MCM4 Gene

Gene Ontology (GO) - Molecular Function for MCM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003678 DNA helicase activity --
GO:0003697 single-stranded DNA binding IEA --
GO:0004003 contributes_to ATP-dependent DNA helicase activity IDA 9305914
GO:0005515 protein binding IPI 12364596
genes like me logo Genes that share ontologies with MCM4: view
genes like me logo Genes that share phenotypes with MCM4: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MCM4 Gene

Localization for MCM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCM4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCM4 Gene COMPARTMENTS Subcellular localization image for MCM4 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for MCM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 8265339
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IDA 19946888
GO:0042555 MCM complex IDA 17296731
genes like me logo Genes that share ontologies with MCM4: view

Pathways for MCM4 Gene

genes like me logo Genes that share pathways with MCM4: view

Pathways by source for MCM4 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for MCM4 Gene
1 Qiagen pathway for MCM4 Gene
1 Cell Signaling Technology pathway for MCM4 Gene

Gene Ontology (GO) - Biological Process for MCM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006260 DNA replication TAS --
GO:0006268 DNA unwinding involved in DNA replication IEA --
GO:0006270 DNA replication initiation IEA --
genes like me logo Genes that share ontologies with MCM4: view

Compounds for MCM4 Gene

(1) Novoseek inferred chemical compound relationships for MCM4 Gene

Compound -log(P) Hits PubMed IDs
hydroxyurea 52.1 3
genes like me logo Genes that share compounds with MCM4: view

Transcripts for MCM4 Gene

Unigene Clusters for MCM4 Gene

Minichromosome maintenance complex component 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MCM4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ·
SP1: - - -
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6: - - - - -
SP7: -
SP8: - -
SP9: - -
SP10:
SP11:
SP12:
SP13:

ExUns: 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b
SP1: - -
SP2: - -
SP3:
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for MCM4 Gene

GeneLoc Exon Structure for
MCM4
ECgene alternative splicing isoforms for
MCM4

Expression for MCM4 Gene

mRNA expression in normal human tissues for MCM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCM4 Gene

SOURCE GeneReport for Unigene cluster for MCM4 Gene Hs.460184

genes like me logo Genes that share expressions with MCM4: view

Orthologs for MCM4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCM4 36
  • 99.69 (n)
  • 99.77 (a)
MCM4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 49 (a)
OneToMany
MCM4 36
  • 85.45 (n)
  • 93.3 (a)
MCM4 37
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MCM4 36
  • 89.38 (n)
  • 94.32 (a)
MCM4 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcm4 36
  • 88.09 (n)
  • 95.01 (a)
Mcm4 16
Mcm4 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCM4 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCM4 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcm4 36
  • 87.86 (n)
  • 95.24 (a)
chicken
(Gallus gallus)
Aves MCM4 36
  • 77.3 (n)
  • 86.73 (a)
MCM4 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCM4 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mcm4-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mcm4 36
  • 75.28 (n)
  • 85.98 (a)
Str.801 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3421 36
zebrafish
(Danio rerio)
Actinopterygii mcm4 36
  • 73.61 (n)
  • 82.19 (a)
mcm4 37
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004956 36
  • 60.57 (n)
  • 64.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta dpa 36
  • 60.1 (n)
  • 64.61 (a)
dpa 37
  • 61 (a)
OneToOne
dpa 38
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea mcm-4 36
  • 55.53 (n)
  • 56.65 (a)
mcm-4 37
  • 52 (a)
OneToOne
mcm-4 38
  • 53 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL026W 36
  • 51.9 (n)
  • 49.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCM4 36
  • 52.31 (n)
  • 50.14 (a)
MCM4 37
  • 40 (a)
OneToMany
MCM4 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C17512g 36
  • 52.68 (n)
  • 49.44 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MCM4 36
  • 53.31 (n)
  • 47.11 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3274 36
bread mold
(Neurospora crassa)
Ascomycetes NCU02539 36
  • 54.28 (n)
  • 50.99 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mcm4 36
  • 53.49 (n)
  • 50.4 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.744 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 59 (a)
OneToOne
Species with no ortholog for MCM4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MCM4 Gene

ENSEMBL:
Gene Tree for MCM4 (if available)
TreeFam:
Gene Tree for MCM4 (if available)

Paralogs for MCM4 Gene

Paralogs for MCM4 Gene

Selected SIMAP similar genes for MCM4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MCM4: view

Variants for MCM4 Gene

Sequence variations from dbSNP and Humsavar for MCM4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs762679 - 47,972,876(-) CAGCA(A/T)GAGGA missense, reference
rs1065129 -- 47,974,083(+) ATGAG(C/G)TGAAG intron-variant
rs1065130 -- 47,974,256(+) AAGAA(A/T)TAAGA intron-variant
rs1065131 -- 47,974,310(+) CATTC(C/T)CCCAG intron-variant
rs1135031 -- 47,977,687(+) TGCCT(A/G)GGCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MCM4 Gene

Variant ID Type Subtype PubMed ID
dgv2234e1 CNV Complex 17122850
nsv831309 CNV Loss 17160897

Relevant External Links for MCM4 Gene

HapMap Linkage Disequilibrium report
MCM4
Human Gene Mutation Database (HGMD)
MCM4

Disorders for MCM4 Gene

(1) OMIM Diseases for MCM4 Gene (602638)

UniProtKB/Swiss-Prot

MCM4_HUMAN
  • Natural killer cell and glucocorticoid deficiency with DNA repair defect (NKGCD) [MIM:609981]: An autosomal recessive disorder characterized by severe intra- and extrauterine growth retardation, microcephaly, decreased numbers of natural killer cells, and recurrent viral infections, most often affecting the respiratory tract and leading to respiratory failure. Affected individuals also have adrenal insufficiency requiring corticosteroid replacement therapy and may have an increased susceptibility to cancer. {ECO:0000269 PubMed:22354167, ECO:0000269 PubMed:22354170, ECO:0000269 PubMed:22499342}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) Novoseek inferred disease relationships for MCM4 Gene

Disease -log(P) Hits PubMed IDs
metastasis 0 1
tumors 0 3

Relevant External Links for MCM4

Genetic Association Database (GAD)
MCM4
Human Genome Epidemiology (HuGE) Navigator
MCM4
genes like me logo Genes that share disorders with MCM4: view

Publications for MCM4 Gene

  1. A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins. (PMID: 7601140) Musahl C. … Knippers R. (Eur. J. Biochem. 1995) 2 3 4 23
  2. The promoters for human DNA-PKcs (PRKDC) and MCM4: divergently transcribed genes located at chromosome 8 band q11. (PMID: 9465298) Connelly M.A. … Anderson C.W. (Genomics 1998) 3 4 23
  3. MCM4 and PRKDC, human genes encoding proteins MCM4 and DNA-PKcs, are close neighbours located on chromosome 8q12-->q13. (PMID: 9284934) Ladenburger E.M. … Knippers R. (Cytogenet. Cell Genet. 1997) 3 4 23
  4. Identification and characterization of a novel component of the human minichromosome maintenance complex. (PMID: 17296731) Sakwe A.M. … Frappier L. (Mol. Cell. Biol. 2007) 3 4 23
  5. Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin. (PMID: 17046832) Masai H. … Arai K. (J. Biol. Chem. 2006) 3 23

Products for MCM4 Gene

Sources for MCM4 Gene

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