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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MCM4 Gene

protein-coding   GIFtS: 67
GCID: GC08P048873

Minichromosome Maintenance Complex Component 4

(Previous name: MCM4 minichromosome maintenance deficient 4 (S. cerevisiae))
(Previous symbol: CDC21)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Minichromosome Maintenance Complex Component 41 2     NKGCD2
CDC211 2 3     DNA Replication Licensing Factor MCM42
P1-CDC212 3     hCdc212
CDC21 Homolog2 3     Homolog Of S. Pombe Cell Devision Cycle 212
MCM4 Minichromosome Maintenance Deficient 4 (S. Cerevisiae)1     Minichromosome Maintenance Deficient 42
CDC542     EC 3.6.4.123
NKCD2     

External Ids:    HGNC: 69471   Entrez Gene: 41732   Ensembl: ENSG000001047387   OMIM: 6026385   UniProtKB: P339913   

Export aliases for MCM4 gene to outside databases

Previous GC identifers: GC08P047965 GC08P048877 GC08P048596 GC08P048923 GC08P049036 GC08P044336


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MCM4 Gene:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that
are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM
proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of
replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of
this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme.
The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the
MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a
DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript
variants encoding the same protein have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for MCM4 Gene: 
MCM4 (minichromosome maintenance complex component 4) is a protein-coding gene. Diseases associated with MCM4 include immunodeficiency with natural-killer cell deficiency, and natural killer cell and glucocorticoid deficiency with dna repair defect, and among its related super-pathways are Activation of the pre-replicative complex and Lagging Strand Synthesis. GO annotations related to this gene include ATP-dependent DNA helicase activity and single-stranded DNA binding. An important paralog of this gene is MCM8.

UniProtKB/Swiss-Prot: MCM4_HUMAN, P33991
Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase
essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active
ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that
a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site
of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute
differentially to the complex helicase activity

Gene Wiki entry for MCM4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008183.19  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MCM4 gene promoter:
         Nkx3-1   C/EBPbeta   Nkx3-1 v4   p53   POU3F2 (N-Oct-5b)   Nkx3-1 v1   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMCM4 promoter sequence
   Search SABiosciences Chromatin IP Primers for MCM4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q11.2   Ensembl cytogenetic band:  8q11.21   HGNC cytogenetic band: 8q12-q13

MCM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCM4 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P048873:  view genomic region     (about GC identifiers)

Start:
48,872,745 bp from pter      End:
48,890,720 bp from pter
Size:
17,976 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MCM4_HUMAN, P33991 (See protein sequence)
Recommended Name: DNA replication licensing factor MCM4  
Size: 863 amino acids; 96558 Da
Subunit: Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit
order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (By simililarity). Interacts with MCMBP
Subcellular location: Nucleus (By similarity)
Miscellaneous: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and
tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in
vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological
active complex
Secondary accessions: Q8NEH1 Q99658

Explore the universe of human proteins at neXtProt for MCM4: NX_P33991

Explore proteomics data for MCM4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P33991

  • MCM4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MCM4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_005905.2  NP_877423.1  

    ENSEMBL proteins: 
     ENSP00000430329   ENSP00000430194   ENSP00000262105   ENSP00000427829   ENSP00000428833  
     ENSP00000427875   ENSP00000430864  
    Reactome Protein details: P33991
    Human Recombinant Protein Products for MCM4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals MCM4 Proteins
    Novus Biologicals MCM4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MCM4 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS8265339
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0042555MCM complex IDA17296731

    MCM4 for ontologies           About GeneDecksing



    MCM4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MCM4
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    Novus Biologicals MCM4 Antibodies
    Abcam antibodies for MCM4
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    ThermoFisher Antibody for MCM4
    LSBio Antibodies in human, mouse, rat for MCM4 

    Assay Products for MCM4: 
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    GenScript Custom Assay Services for MCM4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MCM4 
    Cloud-Clone Corp. CLIAs for MCM4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR018525 MCM_CS
     IPR012340 NA-bd_OB-fold
     IPR004039 Rubredoxin-type_fold
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry P33991

    ProtoNet protein and cluster: P33991

    2 Blocks protein domains:
    IPB001208 MCM family
    IPB008047 Mini-chromosome maintenance (MCM) protein 4 signature


    UniProtKB/Swiss-Prot: MCM4_HUMAN, P33991
    Similarity: Belongs to the MCM family
    Similarity: Contains 1 MCM domain


    MCM4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MCM4_HUMAN, P33991
    Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase
    essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active
    ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that
    a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site
    of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute
    differentially to the complex helicase activity
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Genatlas biochemistry entry for MCM4:
    cell division cycle 21(CDC21) homolog,involved in an early step of DNA replication,participating in the cell cycle
    control of genome duplication

         Enzyme Number (IUBMB): EC 3.6.4.121

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003678DNA helicase activity ----
    GO:0003697single-stranded DNA binding IEA--
    GO:0004003contributes to ATP-dependent DNA helicase activity IDA9305914
    GO:0005515protein binding IPI12364596
         
    MCM4 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mcm4):
     cellular  digestive/alimentary  embryogenesis  growth/size  hematopoietic system 
     immune system  mortality/aging  normal  tumorigenesis 

    MCM4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MCM4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MCM4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MCM4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MCM4 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCM4
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MCM4:
    hsa-miR-651 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidMCM4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for MCM4
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): MCM4 (NM_005914)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCM4
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    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MCM4 About   (see all 13)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Activation of the pre-replicative complex
    Activation of the pre-replicative complex0.67
    Cell cycle Start of DNA replication in early S phase0.54
    DNA Replication0.67
    2Lagging Strand Synthesis
    DNA strand elongation0.65
    Unwinding of DNA0.35
    DNA replication0.63
    3Mitotic G1-G1/S phases
    Mitotic G1-G1/S phases0.80
    G1 to S cell cycle control0.36
    G1/S Transition0.80
    4Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    5CDK-mediated phosphorylation and removal of Cdc6
    Assembly of the pre-replicative complex0.91
    DNA Replication Pre-Initiation0.81
    Removal of licensing factors from origins0.89
    Synthesis of DNA0.79
    Regulation of DNA replication0.89
    S Phase0.79
    Orc1 removal from chromatin0.89
    DNA Replication0.78

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for MCM4
        Meiosis
    Cell cycle Start of DNA replication in early S phase

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MCM4
        Cell Cycle Control of Chromosomal Replication

    1 Cell Signaling Technology (CST) Pathway for MCM4
        Cell Cycle / Checkpoint Control

    1 GeneGo (Thomson Reuters) Pathway for MCM4
        Cell cycle Start of DNA replication in early S phase

    5 BioSystems Pathways for MCM4
        Cell cycle
    G1 to S cell cycle control
    Gastric cancer network 1
    DNA Replication
    C-MYB transcription factor network

    5/21        Reactome Pathways for MCM4 (see all 21)
        Activation of ATR in response to replication stress
    Mitotic G1-G1/S phases
    DNA Replication
    Removal of licensing factors from origins
    Cell Cycle


    2         Kegg Pathways  (Kegg details for MCM4):
        DNA replication
    Cell cycle


    MCM4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MCM4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/292 Interacting proteins for MCM4 (P339911, 2, 3 ENSP000002621054) via UniProtKB, MINT, STRING, and/or I2D (see all 292)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SSRP1Q089452, 3, ENSP000002784124MINT-2984401 MINT-6542674 MINT-2984219 MINT-2984419 MINT-2984494 MINT-8173832 MINT-2984477 MINT-8089790 I2D: score=4 STRING: ENSP00000278412
    HIST1H4AP628053, ENSP000003529804I2D: score=3 STRING: ENSP00000352980
    HIST1H4LP628053, ENSP000003482584I2D: score=3 STRING: ENSP00000348258
    HIST1H4BP628053I2D: score=3 
    HIST1H4CP628053I2D: score=3 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006260DNA replication TAS--
    GO:0006268DNA unwinding involved in DNA replication IEA--
    GO:0006270DNA replication initiation IEA--

    MCM4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MCM4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MCM4

    1 Novoseek inferred chemical compound relationship for MCM4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxyurea 52.1 4 15037254 (2), 17062569 (1)

    Search CenterWatch for drugs/clinical trials and news about MCM4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MCM4 gene (2 alternative transcripts): 
    NM_005914.3  NM_182746.2  

    Unigene Cluster for MCM4:

    Minichromosome maintenance complex component 4
    Hs.460184  [show with all ESTs]
    Unigene Representative Sequence: NM_005914
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000518221 ENST00000523944(uc010lxw.2 uc003xqk.2 uc011ldi.2)
    ENST00000262105(uc003xql.2) ENST00000520994 ENST00000520934 ENST00000524086
    ENST00000519170 ENST00000519138 ENST00000520637 ENST00000518680 ENST00000517709
    ENST00000519470 ENST00000523853 ENST00000518382 ENST00000521261 ENST00000521151

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MCM4:
    hsa-miR-651 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidMCM4 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK022899.1 AK296913.1 AK309812.1 AM493756.1 BC031061.1 X74794.1 

    24/31 DOTS entries (see all 31):

    DT.101985052  DT.101985053  DT.101969207  DT.92452784  DT.418116  DT.91831407  DT.101964477  DT.92452786 
    DT.100793310  DT.100793311  DT.100793307  DT.101978428  DT.408996  DT.120635156  DT.120635241  DT.65286115 
    DT.97855210  DT.100793312  DT.102831993  DT.102831995  DT.95267949  DT.97855208  DT.100648381  DT.100793314 

    24/494 AceView cDNA sequences (see all 494):

    AW059665 BM423607 AW613690 BQ689703 BQ683007 AA429274 BQ058401 BM909380 
    BQ065206 AA336886 BM844209 BG761812 BQ931933 AU130095 AU138190 BQ066435 
    BQ058022 BU838204 BE740475 AW575728 BG395667 BU163628 AI685316 BG763038 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MCM4 (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ·
    SP1:                                -                 -                                                                       -                                 
    SP2:                                -                 -                                                                       -                                 
    SP3:                                -                 -     -                                                                                                   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b
    SP1:        -                 -                                       
    SP2:        -                 -                                       
    SP3:                                                                  
    SP4:                                                                  
    SP5:        -     -           -                                       


    ECgene alternative splicing isoforms for MCM4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MCM4 expression in normal human tissues (normalized intensities)      MCM4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTGGCTGC
    MCM4 Expression
    About this image


    MCM4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 3 entries
             salivary gland ; glandular cells   
             TONGUE   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   
     
     Epithelium (Uncategorized)    fully expand to see all 3 entries
             vagina ; squamous epithelial cells   

    See MCM4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MCM4

    SOURCE GeneReport for Unigene cluster: Hs.460184
        SABiosciences Expression via Pathway-Focused PCR Array including MCM4: 
              Cell Cycle in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MCM4 gene from 10/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mcm41 , 5 minichromosome maintenance deficient 4 homolog (S. more1, 5 88.09(n)1
    95.01(a)1
      16 (10.09 cM)5
    172171  NM_008565.31  NP_032591.31 
     156238975 
    chicken
    (Gallus gallus)
    Aves MCM41 minichromosome maintenance complex component 4 77.3(n)
    86.73(a)
      426764  XM_424376.3  XP_424376.2 
    lizard
    (Anolis carolinensis)
    Reptilia MCM46
    minichromosome maintenance complex component 4
    84(a)
    1 ↔ 1
    GL343207.1(1525837-1549259)
    African clawed frog
    (Xenopus laevis)
    Amphibia mcm4-A2 minichromosome maintenance deficient 4 77.61(n)    U44049.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mcm42 MCM4 minichromosome maintenance deficient 4, mitotin more 74.85(n)   337598  BC056514.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dpa1 , 3 pre-replicative complex formation and
    maintenance more3
    disc proliferation abnormal1
    61(a)3
    59.73(n)1
    63.34(a)1
      356791  NM_057837.41  NP_477185.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mcm-41 , 3 Protein MCM-41 53(a)3
    54.98(n)1
    55.82(a)1
      I(2318428-2321811)3
    1717931  NM_058561.41  NP_490962.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MCM4(YPR019W)4
    MCM41
    Essential helicase component of heterohexameric MCM2-7 more4
    Mcm4p1
    52.31(n)1
    50.14(a)1
      16(596750-599551)4
    8561301, 4  NP_015344.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MCM41 minichromosome maintenance protein 4 (cell division more 53.43(n)
    46.73(a)
      816142  NM_127197.4  NP_179236.3 
    barley
    (Hordeum vulgare)
    Liliopsida Hv.32742 Transcribed sequence with weak similarity to protein more 75.11(n)    BQ459696.1 


    ENSEMBL Gene Tree for MCM4 (if available)
    TreeFam Gene Tree for MCM4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MCM4 gene
    MCM82  
    4 SIMAP similar genes for MCM4 using alignment to 7 protein entries:     MCM4_HUMAN (see all proteins):
    MCM3    MCM7    MCM5    MCM2

    MCM4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/464 SNPs in MCM4 are shown (see all 464)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1818307621,2
    C--48874810(+) TATGGC/TGGGTA 2 -- int11Minor allele frequency- T:0.00EU 1309
    rs119933621,2
    C,F,H--48874811(+) ATGGCG/CGGTAT 2 -- int120Minor allele frequency- C:0.05NA NS EA CSA WA 1962
    rs1860302871,2
    --48874846(+) ATTCTA/GTCATG 2 -- int10--------
    rs342060691,2
    C,F--48874952(+) CATGCA/GAAGAA 4 K E mis13Minor allele frequency- G:0.00NA EU 5949
    rs1915723141,2
    C--48875061(+) TAGAAC/GGGCCA 2 -- int10--------
    rs1490014051,2
    --48875214(+) AAAATA/GTTATT 2 -- int10--------
    rs172875551,2
    C--48875291(+) ATGCTA/GTATGC 2 -- int11Minor allele frequency- G:0.01NS 180
    rs1878410201,2
    C--48875348(+) TTGACC/TCTCTG 4 P S mis10--------
    rs1454173361,2
    F--48875387(+) ATATTA/CCTGAA 4 T P mis11Minor allele frequency- C:0.00NA 4508
    rs2017546091,2
    --48875449(+) AGTTAC/TGTGTT 2 -- int10--------

    HapMap Linkage Disequilibrium report for MCM4 (48872745 - 48890720 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MCM4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831309CNV Loss17160897
    dgv2234e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): MCM4
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for MCM4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602638    OMIM disorders: --

    UniProtKB/Swiss-Prot: MCM4_HUMAN, P33991
  • Natural killer cell and glucocorticoid deficiency with DNA repair defect (NKGCD) [MIM:609981]: An
    autosomal recessive disorder characterized by severe intra- and extrauterine growth retardation, microcephaly,
    decreased numbers of natural killer cells, and recurrent viral infections, most often affecting the respiratory
    tract and leading to respiratory failure. Affected individuals also have adrenal insufficiency requiring
    corticosteroid replacement therapy and may have an increased susceptibility to cancer. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • 15 diseases for MCM4:    About MalaCards
    immunodeficiency with natural-killer cell deficiency    natural killer cell and glucocorticoid deficiency with dna repair defect    merkel cell carcinoma    esophageal cancer
    t cell deficiency    short stature    medulloblastoma    cytochrome p450
    chronic lymphocytic leukemia    esophagitis    lung cancer    melanoma
    gastric cancer    leukemia    breast cancer


    MCM4 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for MCM4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 0 1 17222376 (1)
    tumors 0 5 16595783 (1), 16051427 (1), 20398247 (1)

    Genetic Association Database (GAD): MCM4
    Human Genome Epidemiology (HuGE) Navigator: MCM4 (4 documents)

    Export disorders for MCM4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MCM4 gene, integrated from 9 sources (see all 134):
    (articles sorted by number of sources associating them with MCM4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins. (PubMed id 7601140)1, 2, 3, 9 Musahl C.... Knippers R. (1995)
    2. The promoters for human DNA-PKcs (PRKDC) and MCM4: divergently transcribed genes located at chromosome 8 band q11. (PubMed id 9465298)1, 2, 9 Connelly M.A.... Anderson C.W. (1998)
    3. MCM4 and PRKDC, human genes encoding proteins MCM4 and DNA-PKcs, are close neighbours located on chromosome 8q12-->q13. (PubMed id 9284934)1, 2, 9 Ladenburger E.M.... Knippers R. (1997)
    4. Identification and characterization of a novel component of the human minichromosome maintenance complex. (PubMed id 17296731)1, 2, 9 Sakwe A.M....Frappier L. (2007)
    5. MCM4 mutation causes adrenal failure, short stature, a nd natural killer cell deficiency in humans. (PubMed id 22354170)1, 2 Hughes C.R....Metherell L.A. (2012)
    6. Partial MCM4 deficiency in patients with growth retard ation, adrenal insufficiency, and natural killer cell deficiency. (PubMed id 22354167)1, 2 Gineau L....Jouanguy E. (2012)
    7. Recessive mutations in MCM4/PRKDC cause a novel syndro me involving a primary immunodeficiency and a disorder of DNA repair. (PubMed id 22499342)1, 2 Casey J.P....Ennis S. (2012)
    8. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    9. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    10. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4173 HGNC: 6947 AceView: MCM4 Ensembl:ENSG00000104738 euGenes: HUgn4173
    ECgene: MCM4 Kegg: 4173 H-InvDB: MCM4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MCM4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MCM4 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mcm4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MCM4 gene:
    Search GeneIP for patents involving MCM4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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