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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MCM3AP Gene

protein-coding GIFtS: 59
GCID: GC21M047655

minichromosome maintenance complex component 3 associated...

(Previous names: minichromosome maintenance deficient (S. cerevisiae) 3-associated...)

Explore 2 diseases affiliated with
MCM3AP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, and/or ¹¹Nature:405,311-319 and CroW21)
About This Section

Aliases
Minichromosome Maintenance Complex Component 3 Associated Protein¹ ²		Human MRNA For MCM3 Import Factor11
GANP¹ ² ³		80 KDa MCM3-Associated Protein²
MAP80² ³ ⁵		Germinal Center-Associated Nuclear Protein²
SAC3¹ ²		Germinal-Centre Associated Nuclear Protein²
KIAA0572¹ ³		MCM3 Import Protein²
Map80¹		MCM3 Minichromosome Maintenance Deficient 3 Associated Protein²
MCM3 Minichromosome Maintenance Deficient 3 (S. Cerevisiae) Associated Protein¹		Minichromosome Maintenance Deficient 3-Associated Protein²
Minichromosome Maintenance Deficient (S. Cerevisiae) 3-Associated Protein¹		Protein GANP³

External Ids:	HGNC: 6946¹	Entrez Gene: 8888²	Ensembl: ENSG00000160294⁷	OMIM: 603294⁵	UniProtKB: O60318³

Export aliases for MCM3AP gene to outside databases

Previous GC identifers: GC21M044161 GC21M046511 GC21M046479 GC21M033037

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MCM3AP:

The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA

replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have

phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal

center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA

replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3,

suggesting that this protein may also facilitate MCM3 nuclear localization. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MCM3A_HUMAN, O60318

Function: May be involved in the nuclear localization pathway of MCM3

Gene Wiki entry for MCM3AP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

RefSeq DNA sequence:

NC_000021.8 NC_018932.1 NT_011515.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MCM3AP gene promoter:
GR PPAR-gamma1 GR-beta PPAR-gamma2 GR-alpha NF-kappaB NF-kappaB1 Evi-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MCM3AP promoter sequence

Search SABiosciences Chromatin IP Primers for MCM3AP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCM3AP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band: 21q22.3

MCM3AP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCM3AP gene location

GeneLoc information about chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21M047655:	GeneLoc	Nature:405,311-319
Start:	47,655,047 bp from pter	33,161,516 bp from centromere
End:	47,706,211 bp from pter	33,211,704 bp from centromere
Size:	51,165 bases	50,189 bases
Orientation:	minus strand	minus strand

Whole chromosome sequencing:
cDNA sequence:	AB005543
genomic clones:	R178H12 CTD2308H15

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MCM3A_HUMAN, O60318 (See protein sequence)

Recommended Name: 80 kDa MCM3-associated protein

Size: 1980 amino acids; 218405 Da

Subunit: Interacts with MCM3

Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)

1 PDB 3D structure from and Proteopedia for MCM3AP:

4DHX (3D)

Secondary accessions: Q2M3C1 Q9UMT4

Explore the universe of human proteins at neXtProt for MCM3AP: NX_O60318

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60318

MCM3AP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003897.2

ENSEMBL proteins:

ENSP00000380820 ENSP00000408934 ENSP00000291688

Human Recombinant Protein Products for MCM3AP:

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	Uscn Proteins for MCM3AP

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	16780588
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	IDA	16780588

MCM3AP for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for MCM3AP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MCM3AP for domains About GeneDecksing

1 InterPro domain/family:

IPR005062 SAC3/GANP/Nin1/mts3/eIF-3-p25

Graphical View of Domain Structure for InterPro Entry O60318

ProtoNet protein and cluster: O60318

1 Blocks protein family: IPB005062 SAC3/GANP family

UniProtKB/Swiss-Prot: MCM3A_HUMAN, O60318

Similarity: Belongs to the SAC3 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MCM3A_HUMAN, O60318

Function: May be involved in the nuclear localization pathway of MCM3

Genatlas biochemistry entry for MCM3AP:

minichromosome maintenance deficient (S cerevisiae) 3-associated protein,80kDa,involved in the nuclear localization of

MCM3

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	--	--
GO:0003677	DNA binding	TAS	9712829

MCM3AP for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for MCM3AP:

Decreased TP53 protein express

G0/1 arrest

Increased G1 DNA content

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mcm3ap):

cellular

hematopoietic system

immune system

mortality/aging

MCM3AP for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Mcm3ap^tm2Imku for MCM3AP

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MCM3AP

miRNA Products:		OriGene 3'-UTR Clone: MCM3AP Browse MicroRNA Expression Plasmids
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		hsa-miR-23b hsa-miR-4251 hsa-miR-130a* hsa-miR-23a hsa-miR-23c
		Browse SwitchGear 3'UTR luciferase reporter plasmids

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM3AP

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MCM3AP

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

5/28 Interacting proteins for MCM3AP (O60318^{2, 3} ENSP00000291688⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 28)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENY2	Q9NPA8²^,³, ENSP00000339861⁴	MINT-65568 I2D: score=5 STRING: ENSP00000339861
SMAD3	P84022²^,³, ENSP00000332973⁴	MINT-61711 I2D: score=3 STRING: ENSP00000332973
CDC73	Q6P1J9²^,³, ENSP00000356405⁴	MINT-8251142 I2D: score=2 STRING: ENSP00000356405
CRMP1	Q14194²^,³	MINT-63169 I2D: score=3
FAM118B	Q9BPY3²^,³	MINT-8255148 I2D: score=2

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006260	DNA replication	TAS	9712829
GO:0006606	protein import into nucleus	TAS	9712829

MCM3AP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MCM3AP
Search CenterWatch for drugs/clinical trials and news about MCM3AP / MCM3A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MCM3AP gene:

NM_003906.3

Unigene Cluster for MCM3AP:

Minichromosome maintenance complex component 3 associated protein

Hs.389037 [show with all ESTs]

Unigene Representative Sequence: AJ010089

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000467026(uc002zip.1) ENST00000496607(uc002ziq.1) ENST00000486937(uc002zio.1)

ENST00000397708 ENST00000481113 ENST00000494755 ENST00000479557 ENST00000426537

ENST00000495475 ENST00000291688(uc002zir.1)

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		5 QIAGEN miScript miRNA Assays for microRNAs that regulate MCM3AP:
		hsa-miR-23b hsa-miR-4251 hsa-miR-130a* hsa-miR-23a hsa-miR-23c
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AB011144.1 AJ010089.1 AK026578.1 AK095181.1 AK124490.1 AK126313.1 AK127239.1 AK304208.1

BC004497.2 BC013285.2 BC104958.1 BC104960.1

24/38 DOTS entries (see all 38):

DT.455808 DT.95176445 DT.91956595 DT.95176450 DT.100037807 DT.121134508 DT.100037808 DT.99936808

DT.100824299 DT.121134485 DT.417767 DT.97859821 DT.100742201 DT.101970035 DT.121134403 DT.75172821

DT.95176446 DT.121134401 DT.75123316 DT.95177405 DT.99936890 DT.121134365 DT.121134472 DT.91961730

24/346 AceView cDNA sequences (see all 346):

BQ677575 AA721069 BU557007 BI094325 BU181950 BM728203 CA455404 AA251599

AA827373 BM931459 BG679482 BU537932 BF439374 AA669189 BQ070508 CR604265

AA614335 BC004497 BU188793 AA702534 AA515301 BU165571 BQ431474 BU153428

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for MCM3AP (see all 16) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16	^	17	^	18	^	19a	·	19b	^	20a	·	20b	^	21a	·
SP1:																																															-
SP2:																																															-
SP3:																															-
SP4:																															-
SP5:																															-

ExUns:	21b	^	22a	·	22b	^	23	^	24	^	25	^	26a	·	26b	^	27	^	28
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for MCM3AP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MCM3AP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGATAAACC

About this image

MCM3AP expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Metanephros

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MCM3AP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MCM3AP

SOURCE GeneReport for Unigene cluster: Hs.389037

SABiosciences Custom PCR Arrays for MCM3AP

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCM3AP gene from 9/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mcm3ap^{1 , 5}	minichromosome maintenance deficient 3 (S. cerevisiae) more^{1, 5}	80.52(n)¹ 79.27(a)¹		10 (38.88 cM)⁵ 54387¹ NM_019434.2¹ NP_062307.2¹ 76468971⁵
chicken (Gallus gallus)	Aves	MCM3AP¹	minichromosome maintenance complex component 3 associated more	62.62(n) 60.59(a)		424036 XM_421891.3 XP_421891.3
lizard (Anolis carolinensis)	Reptilia	MCM3AP⁶	--	55(a)	1 ↔ 1	1(123010271-123053781)
African clawed frog (Xenopus laevis)	Amphibia	BI446049.1²	--	75.26(n)		BI446049.1
zebrafish (Danio rerio)	Actinopterygii	mcm3ap¹	MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) more	51.9(n) 45.42(a)		436589 XM_684142.4 XP_689234.1
fruit fly (Drosophila melanogaster)	Insecta	xmas-2³	embryonic development RNA binding	43(a)		--
worm (Caenorhabditis elegans)	Secernentea	F20D12.2³	--	33(a)		IV(7948864-7953612) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G54380⁶ AT3G06290⁶	SAC3/GANP/Nin1/mts3/eIF-3 p25 family protein	25(a) 13(a)	many ↔ many many ↔ many	3(20133893-20137007) 3(1899042-1907297)
rice (Oryza sativa)	Liliopsida	-- --	SAC3/GANP family protein, expressed	23(a) 13(a)	many ↔ many many ↔ many	3(13216769-13220951) 7(26951452-26961733)

ENSEMBL Gene Tree for MCM3AP (if available)
TreeFam Gene Tree for MCM3AP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MCM3AP gene

SAC3D1²

MCM3AP for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 21 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs17183417^1,2	C,F	--	47654609(-)	`AAAGCG/TTGGAG`	2	--	int¹ ds500¹		3		NS NA	300
rs190843879^1,2		--	47654637(+)	`TACACC/TGTCTC`	2	--	int¹ ds500¹		0	--	--	--	--
rs17177030^1,2	C,F	--	47654666(-)	`TCCCGG/TAGAGG`	2	--	ds500¹ int¹		2		NS NA	266
rs17177023^1,2	F	--	47654667(-)	`TTCCCG/AGAGAG`	2	--	int¹ ds500¹		2		NS NA	150
rs111313648^1,2	C	--	47654677(+)	`TTCTGC/-TTTCT`	2	--	ds500¹ int¹		2		CSA	6
rs182310823^1,2		--	47654709(+)	`TTCCAC/TCCTCT`	2	--	ds500¹ int¹		0	--	--	--	--
rs149675675^1,2		--	47654736(+)	`CAATTC/GAGGCC`	2	--	ds500¹ int¹		0	--	--	--	--
rs186578408^1,2		--	47654746(+)	`CCACGC/TCTCAT`	2	--	ds500¹ int¹		0	--	--	--	--
rs189599584^1,2		--	47654761(+)	`ATTCTC/TTGAGA`	2	--	ds500¹ int¹		0	--	--	--	--
rs17177009^1,2	C,F	--	47654975(-)	`CATGAC/TCTCCT`	2	--	ds500¹ int¹		1		NS	180

HapMap Linkage Disequilibrium report for MCM3AP (47655047 - 47706211 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for MCM3AP
5 CNVs: 61987 39308 67820 44061 103124
1 Indel: 60392
Human Gene Mutation Database (HGMD): MCM3AP

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MCM3AP for disorders           About GeneDecksing

OMIM gene information: 603294    OMIM disorders: --

2 diseases for MCM3AP:    About MalaCards

malignant glioma cholangiocarcinoma

1 Novoseek disease relationship for MCM3AP gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	1	16431081 (1)

Export disorders for MCM3AP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MCM3AP gene, integrated from 9 sources (see all 43):
(articles sorted by number of sources associating them with MCM3AP)

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Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization. (PubMed id 9712829)^{1, 2, 3, 9} Takei Y. and Tsujimoto G. (1998)
Functional interaction between the glucocorticoid receptor and GANP/MCM3AP. (PubMed id 16914116)^{1, 3, 9} Osman W....Zilliacus J. (2006)
Structure, expression, and chromosomal localization of the human gene encoding a germinal center-associated nuclear protein (GANP) that associates with MCM3 involved in the initiation of DNA replication. (PubMed id 11024281)^{1, 2, 9} Abe E.... Sakaguchi N. (2000)
MCM3AP is transcribed from a promoter within an intro n of the overlapping gene for GANP. (PubMed id 21195085)^{1, 3} Wickramasinghe V.O....Takei Y. (2011)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)^{1, 2} Nagase T....Ohara O. (1998)
Cholangiocarcinomas associated with long-term inflamm ation express the activation-induced cytidine deaminase and germinal center-ass ociated nuclear protein involved in immunoglobulin V-region diversification. (PubMed id 19578742)^{1, 9} Chan-On W....Sakaguchi N. (2009)
Decreased expression of germinal center-associated nu clear protein is involved in chromosomal instability in malignant gliomas. (PubMed id 19686285)^{1, 9} Ohta K....Sakaguchi N. (2009)
The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3. (PubMed id 12226073)^{1, 9} Takei Y....Laskey R. (2002)
MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3. (PubMed id 11258703)^{1, 9} Takei Y....Laskey R. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8888	HGNC: 6946	AceView: MCM3AP	Ensembl:ENSG00000160294	euGenes: HUgn8888
ECgene: MCM3AP	H-InvDB: MCM3AP

(According to HUGE)
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HUGE: KIAA0572

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MCM3AP	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/mcm3ap/

Intellectual Property for MCM3AP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MCM3AP gene:
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GeneCards and IP:
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