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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MCM3AP Gene

protein-coding   GIFtS: 61
GCID: GC21M047655

Minichromosome Maintenance Complex Component 3 Associated...

(Previous names: minichromosome maintenance deficient (S. cerevisiae) 3-associated...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
Minichromosome Maintenance Complex Component 3 Associated Protein1 2     SAC32
MAP802 3 5     Germinal Center-Associated Nuclear Protein2
Germinal-Centre Associated Nuclear Protein1 2     MCM3 Import Protein2
GANP2 3     MCM3 Minichromosome Maintenance Deficient 3 Associated Protein2
MCM3 Minichromosome Maintenance Deficient 3 (S. Cerevisiae) Associated
Protein1
     Minichromosome Maintenance Deficient 3-Associated Protein2
Minichromosome Maintenance Deficient (S. Cerevisiae) 3-Associated Protein1     KIAA05723
Human MRNA For MCM3 Import Factor11     Protein GANP3
80 KDa MCM3-Associated Protein2     

External Ids:    HGNC: 69461   Entrez Gene: 88882   Ensembl: ENSG000001602947   OMIM: 6032945   UniProtKB: O603183   

Export aliases for MCM3AP gene to outside databases

Previous GC identifers: GC21M044161 GC21M046511 GC21M046479 GC21M033037


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MCM3AP Gene:
The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA
replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have
phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal
center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA
replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with
MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. (provided by RefSeq, Jul 2008)

GeneCards Summary for MCM3AP Gene: 
MCM3AP (minichromosome maintenance complex component 3 associated protein) is a protein-coding gene. Diseases associated with MCM3AP include malignant glioma, and cholangiocarcinoma. GO annotations related to this gene include DNA binding. An important paralog of this gene is SAC3D1.

UniProtKB/Swiss-Prot: MCM3A_HUMAN, O60318
Function: May be involved in the nuclear localization pathway of MCM3

Gene Wiki entry for MCM3AP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NT_011515.12  NC_018932.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MCM3AP gene promoter:
         GR   PPAR-gamma1   GR-beta   PPAR-gamma2   GR-alpha   NF-kappaB   NF-kappaB1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MCM3AP promoter sequence

   Search SABiosciences Chromatin IP Primers for MCM3AP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCM3AP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
MCM3AP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCM3AP gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M047655:   GeneLoc Nature:405,311-319
Start:
47,655,047 bp from pter       33,161,516 bp from centromere
End:
47,706,211 bp from pter 33,211,704 bp from centromere
Size:
51,165 bases 50,189 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: AB005543
genomic clones: R178H12 CTD2308H15


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MCM3A_HUMAN, O60318 (See protein sequence)
Recommended Name: 80 kDa MCM3-associated protein  
Size: 1980 amino acids; 218405 Da
Subunit: Interacts with MCM3
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
1 PDB 3D structure from and Proteopedia for MCM3AP:
4DHX (3D)    
Secondary accessions: Q2M3C1 Q9UMT4

Explore the universe of human proteins at neXtProt for MCM3AP: NX_O60318

Explore proteomics data for MCM3AP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60318

  • MCM3AP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MCM3AP Protein Expression
    REFSEQ proteins: NP_003897.2  
    ENSEMBL proteins: 
     ENSP00000380820   ENSP00000408934   ENSP00000291688  

    Human Recombinant Protein Products for MCM3AP: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MCM3AP 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16780588
    GO:0005737cytoplasm ----
    GO:0005829cytosol IDA16780588

    MCM3AP for ontologies           About GeneDecksing



    MCM3AP Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR005062 SAC3/GANP/Nin1/mts3/eIF-3-p25

    Graphical View of Domain Structure for InterPro Entry O60318

    ProtoNet protein and cluster: O60318

    1 Blocks protein domain: IPB005062 SAC3/GANP family

    UniProtKB/Swiss-Prot: MCM3A_HUMAN, O60318
    Similarity: Belongs to the SAC3 family


    MCM3AP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MCM3A_HUMAN, O60318
    Function: May be involved in the nuclear localization pathway of MCM3

         Genatlas biochemistry entry for MCM3AP:
    minichromosome maintenance deficient (S cerevisiae) 3-associated protein,80kDa,involved in the nuclear
    localization of MCM3

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS9712829
         
    MCM3AP for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MCM3AP:
     Decreased TP53 protein express  G0/1 arrest  Increased G1 DNA content 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mcm3ap):
     cellular  hematopoietic system  immune system  mortality/aging 

    MCM3AP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mcm3aptm2Imku for MCM3AP

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MCM3AP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MCM3AP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MCM3AP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MCM3AP 

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    Inhib. RNA
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM3AP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MCM3AP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/28 Interacting proteins for MCM3AP (O603182, 3 ENSP000002916884) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENY2Q9NPA82, 3, ENSP000003398614MINT-65568 I2D: score=5 STRING: ENSP00000339861
    SMAD3P840222, 3, ENSP000003329734MINT-61711 I2D: score=3 STRING: ENSP00000332973
    CDC73Q6P1J92, 3, ENSP000003564054MINT-8251142 I2D: score=2 STRING: ENSP00000356405
    CRMP1Q141942, 3MINT-63169 I2D: score=3 
    FAM118BQ9BPY32, 3MINT-8255148 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication TAS9712829
    GO:0006606protein import into nucleus TAS9712829

    MCM3AP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MCM3AP (MCM3A)

    Search CenterWatch for drugs/clinical trials and news about MCM3AP / MCM3A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MCM3AP gene: 
    NM_003906.3  

    Unigene Cluster for MCM3AP:

    Minichromosome maintenance complex component 3 associated protein
    Hs.389037  [show with all ESTs]
    Unigene Representative Sequence: AJ010089
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467026(uc002zip.1) ENST00000496607(uc002ziq.1) ENST00000486937(uc002zio.1)
    ENST00000397708 ENST00000481113 ENST00000494755 ENST00000479557 ENST00000426537
    ENST00000495475 ENST00000291688(uc002zir.1)
    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate MCM3AP:
    hsa-miR-23b hsa-miR-4251 hsa-miR-130a* hsa-miR-23a hsa-miR-23c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCM3AP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCM3AP

    Additional mRNA sequence: 

    AB011144.1 AJ010089.1 AK026578.1 AK095181.1 AK124490.1 AK126313.1 AK127239.1 AK304208.1 
    BC004497.2 BC013285.2 BC104958.1 BC104960.1 

    24/38 DOTS entries (see all 38):

    DT.455808  DT.95176445  DT.91956595  DT.95176450  DT.100037807  DT.121134508  DT.100037808  DT.99936808 
    DT.100824299  DT.121134485  DT.417767  DT.97859821  DT.100742201  DT.101970035  DT.121134403  DT.75172821 
    DT.95176446  DT.121134401  DT.75123316  DT.95177405  DT.99936890  DT.121134365  DT.121134472  DT.91961730 

    24/346 AceView cDNA sequences (see all 346):

    BU165571 AW057791 BE906050 AA515301 BU177791 AI446697 BU162851 AI033403 
    AA614335 AA721087 BF436206 AA476353 BQ070508 NM_003906 CR604265 CA502806 
    AW338932 CN480031 BU177398 BQ446259 AA827373 AA251599 BC004497 AI687381 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for MCM3AP (see all 16)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a ·
    SP1:                                                                                                                                            -               
    SP2:                                                                                                                                            -               
    SP3:                                                                                            -                                                               
    SP4:                                                                                            -                                                               
    SP5:                                                                                            -                                                               

    ExUns: 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for MCM3AP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MCM3AP expression in normal human tissues (normalized intensities)      MCM3AP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGATAAACC
    MCM3AP Expression
    About this image


    MCM3AP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Trigeminal Ganglion   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Superior Cervical Ganglion   
     
     Heart (Cardiovascular System)
             Atrioventricular Node
     
     Kidney (Urinary System)
             Metanephros
     
     Oral Cavity (Gastrointestinal Tract)
             salivary gland   

    See MCM3AP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MCM3AP

    SOURCE GeneReport for Unigene cluster: Hs.389037
        SABiosciences Custom PCR Arrays for MCM3AP
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCM3AP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM3AP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MCM3AP gene from 8/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mcm3ap1 , 5 minichromosome maintenance deficient 3 (S. cerevisiae) more1, 5 80.52(n)1
    79.27(a)1
      10 (38.88 cM)5
    543871  NM_019434.21  NP_062307.21 
     764689715 
    chicken
    (Gallus gallus)
    Aves MCM3AP1 minichromosome maintenance complex component 3 associated more 62.62(n)
    60.59(a)
      424036  XM_421891.3  XP_421891.3 
    lizard
    (Anolis carolinensis)
    Reptilia MCM3AP6
    minichromosome maintenance complex component 3 ass...
    56(a)
    1 ↔ 1
    1(123011059-123058460)
    African clawed frog
    (Xenopus laevis)
    Amphibia BI446049.12   -- 75.26(n)    BI446049.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mcm3ap1 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) more 51.9(n)
    45.42(a)
      436589  XM_684142.4  XP_689234.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta xmas-23 embryonic development RNA binding 43(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea F20D12.23   -- 33(a)   IV(7948864-7953612)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SAC3(YDR159W)4 Nuclear pore-associated protein; required for biogenesis more   --   4(771877-775782) 851737  NP_010443.1 


    ENSEMBL Gene Tree for MCM3AP (if available)
    TreeFam Gene Tree for MCM3AP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MCM3AP gene
    SAC3D12  
    1 SIMAP similar gene for MCM3AP using alignment to 5 protein entries:     MCM3A_HUMAN (see all proteins):
    MCM3AP_var1

    MCM3AP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/915 SNPs in MCM3AP are shown (see all 915)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0354724
    A colorectal cancer sample4--see VAR_0354722 L V mis40--------
    VAR_0539734
    ----see VAR_0539732 R C mis40--------
    VAR_0192404
    ----see VAR_0192402 S L mis40--------
    VAR_0192474
    ----see VAR_0192472 D E mis40--------
    VAR_0192514
    ----see VAR_0192512 A V mis40--------
    VAR_0192494
    ----see VAR_0192492 A T mis40--------
    VAR_0192504
    ----see VAR_0192502 L R mis40--------
    VAR_0192484
    ----see VAR_0192482 V I mis40--------
    VAR_0192414
    ----see VAR_0192412 M V mis40--------
    rs171766671,2
    C,F--38167556(-) AACAGAG/-GGATC 1 -- int12Minor allele frequency- -:0.06NS CSA 180

    HapMap Linkage Disequilibrium report for MCM3AP (47655047 - 47706211 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for MCM3AP (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2393806CNV Deletion18987734
    esv2641041CNV Deletion19546169
    nsv509804CNV Insertion20534489
    nsv3547CNV Insertion18451855
    esv8319CNV Loss19470904
    esv22993CNV Loss19812545
    nsv519904CNV Loss19592680
    dgv4817n71CNV Loss21882294
    nsv914135CNV Loss21882294
    esv6085CNV Gain19470904


    Human Gene Mutation Database (HGMD): MCM3AP
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for MCM3AP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603294    OMIM disorders: --

    2 diseases for MCM3AP:    About MalaCards
    malignant glioma    cholangiocarcinoma


    MCM3AP for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for MCM3AP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 16431081 (1)


    Export disorders for MCM3AP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MCM3AP gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with MCM3AP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization. (PubMed id 9712829)1, 2, 3, 9 Takei Y. and Tsujimoto G. (1998)
    2. Functional interaction between the glucocorticoid receptor and GANP/MCM3AP. (PubMed id 16914116)1, 3, 9 Osman W....Zilliacus J. (2006)
    3. Structure, expression, and chromosomal localization of the human gene encoding a germinal center-associated nuclear protein (GANP) that associates with MCM3 involved in the initiation of DNA replication. (PubMed id 11024281)1, 2, 9 Abe E.... Sakaguchi N. (2000)
    4. MCM3AP is transcribed from a promoter within an intro n of the overlapping gene for GANP. (PubMed id 21195085)1, 3 Wickramasinghe V.O....Takei Y. (2011)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (1998)
    7. Cholangiocarcinomas associated with long-term inflamm ation express the activation-induced cytidine deaminase and germinal center-ass ociated nuclear protein involved in immunoglobulin V-region diversification. (PubMed id 19578742)1, 9 Chan-On W....Sakaguchi N. (2009)
    8. Decreased expression of germinal center-associated nu clear protein is involved in chromosomal instability in malignant gliomas. (PubMed id 19686285)1, 9 Ohta K....Sakaguchi N. (2009)
    9. The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3. (PubMed id 12226073)1, 9 Takei Y....Laskey R. (2002)
    10. MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3. (PubMed id 11258703)1, 9 Takei Y....Laskey R. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8888 HGNC: 6946 AceView: MCM3AP Ensembl:ENSG00000160294 euGenes: HUgn8888
    ECgene: MCM3AP H-InvDB: MCM3AP

    (According to HUGE)
    About This Section
    HUGE: KIAA0572

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MCM3AP Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mcm3ap/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MCM3AP gene:
    Search GeneIP for patents involving MCM3AP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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