MCM3 Gene
protein-coding GIFtS : 65 GCID: GC06 M052128
minichromosome maintenance complex component 3 minichromosome maintenance deficient (S. cerevisiae) 3,...
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Aliasesfor MCM3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Minichromosome Maintenance Complex Component 3 1 2 RLFB2 P1-MCM32 3 Cervical Cancer Proto-Oncogene 52 DNA Polymerase Alpha Holoenzyme-Associated Protein P12 3 DNA Replication Factor MCM32 P1021 DNA Replication Licensing Factor MCM32 RLF Subunit Beta2 3 HRlf Beta Subunit2 MCM3 Minichromosome Maintenance Deficient 3 (S. Cerevisiae)1 MCM3 Minichromosome Maintenance Deficient 32 Minichromosome Maintenance Deficient (S. Cerevisiae) 31 Minichromosome Maintenance Deficient 32 HCC52 Replication Licensing Factor, Beta Subunit2 P1.H1 EC 3.6.4.123
Export aliases for MCM3 gene to outside databases Previous GC identifers: GC06M052130 GC06M052175 GC06M052236 GC06M051960
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Summariesfor MCM3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MCM3 : The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2012) UniProtKB/Swiss-Prot: MCM3_HUMAN, P25205 Function : Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essentialfor 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation Gene Wiki entry for MCM3
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Genomic Viewsfor MCM3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_007592.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MCM3 gene promoter:NF-YA Pax-6 MyoD NF-YB CBF-B CBF-A ZIC2/Zic2 CP1A NF-Y CBF(2) Other transcription factors Search SABiosciences Chromatin IP Primers for MCM3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6p12 Ensembl cytogenetic band: 6p12.2 HGNC cytogenetic band: 6p12 MCM3 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06M052128: view genomic region
(about GC identifiers )
Start: 52,128,807 bp from pter End:
52,149,582 bp from pter
Size: 20,776 bases Orientation:
minus strand
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Proteinsfor MCM3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MCM3_HUMAN, P25205 See
protein sequence )Recommended Name: Size : 808 amino acids; 90981 DaSubunit : Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit orderMCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (By simililarity). Associated with the replication-specific DNA polymerase alpha. Interacts with MCMBP
Subcellular location : NucleusMiscellaneous : Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetramericcomplexes with unclear biological significance. The MCM2-7 hexamer is the proposed physiological active complex
Secondary accessions : Q92660 Q9BTR3 Q9NUE7Explore the universe of human proteins at neXtProt for MCM3: NX_P25205 Post-translational modifications:
O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P25205 MCM3 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (2 alternative transcripts): NP_001257401.1 NP_002379.3 ENSEMBL proteins: ENSP00000229854 ENSP00000407651 ENSP00000388647 Reactome Protein details: P25205 Human Recombinant Protein Products: Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9 ): About this table
About GeneDecksing MCM3 Antibody Products: Assay Products for MCM3:
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Protein
Domains /for MCM3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P25205 ProtoNet protein and cluster: P25205
2 Blocks protein families : IPB001208 IPB008046 UniProtKB/Swiss-Prot: MCM3_HUMAN, P25205 Similarity : Belongs to the MCM familySimilarity : Contains 1 MCM domain
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Functionfor MCM3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: MCM3_HUMAN, P25205 Function : Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essentialfor 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation Catalytic activity : ATP + H(2)O = ADP + phosphate
Genatlas biochemistry entry for MCM3 cell division cycle,early S-phase-like-3,participating in the cell cycle control of genome duplication Enzyme Number (IUBMB): EC 3.6.4.12 1 Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MCM3 (NM_002388 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MCM3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MCM3
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM3
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing 1 GenomeRNAi human phenotype for MCM3 :Animal Models: 6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mcm3) :About GeneDecksing
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Pathways & Interactionsfor MCM3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/12 super-pathways (see all 12 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Ubiquitinated Orc1 is degraded by the proteasome 2 Cell cycle 3 Lagging Strand Synthesis 4 Cell cycle_Start of DNA replication in early S phase 5 Activation of ATR in response to replication stress
Pathway sources See GeneCards unified pathways Show all pathways 1 1 1 1 4 5/21 (see all 21 )2 (Kegg details for MCM3) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MCM3 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/228 Interacting proteins for MCM3 (P25205 1 , 2 , 3 ENSP00000229854 4 via UniProtKB, MINT, STRING , and/or I2D (see all 228 )Interactant Interaction Details GeneCard External ID(s) HIST1H4B P62805 1 , 3 EBI-355153,EBI-302023 I2D:
score=3 HIST1H4C P62805 1 , 3 EBI-355153,EBI-302023 I2D:
score=3 HIST1H4D P62805 1 , 3 EBI-355153,EBI-302023 I2D:
score=3 HIST1H4E P62805 1 , 3 EBI-355153,EBI-302023 I2D:
score=3 HIST1H4F P62805 1 , 3 EBI-355153,EBI-302023 I2D:
score=3
About this table Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000075 cell cycle checkpoint
TAS -- GO:0000082 G1/S transition of mitotic cell cycle
TAS -- GO:0000084 S phase of mitotic cell cycle
TAS -- GO:0000216 M/G1 transition of mitotic cell cycle
TAS -- GO:0000278 mitotic cell cycle
TAS --
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Drugs & Compoundsfor MCM3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for MCM3 1 Novoseek chemical compound relationship for MCM3 gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
estrogen
0
2
14501812 (2)
MCM3
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Transcriptsfor MCM3 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MCM3 gene (2 alternative transcripts): NM_001270472.1 NM_002388.4 Unigene Cluster for MCM3:
Minichromosome maintenance complex component 3 Hs.179565 [show with all ESTs ] Unigene Representative Sequence: NM_002388 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000229854 (uc003pan.1 uc011dwu.1 ) ENST00000421471 ENST00000476448 ENST00000462365 ENST00000419835 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MCM3 (NM_002388 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MCM3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MCM3
Additional cDNA sequence: AK222586.1 AK299566.1 AK300754.1 AK301704.1 AK312928.1 AY032603.1 BC001626.1 BC003509.1 D38073.1 X62153.2
24 DOTS entries : DT.95265124 DT.456368
DT.100827031 DT.95265132 DT.99994761 DT.91761440 DT.91761437 DT.92064219 DT.121345104 DT.121345133 DT.121345139 DT.99990224 DT.100827037 DT.100827043 DT.102833209 DT.121345126 DT.121345128 DT.121345136 DT.91761446 DT.91761450 DT.95205185 DT.95265138 DT.95265140 DT.97861316 24/449 AceView cDNA sequences (see all 449 ):
BE783059 CB125974 BU558287 AI832747 BM788699 BQ061652 BI599305 BU753498 AL079481 BQ064568 BQ653192 CB136378 BM790143 BM561561 CO399524 BE780580 BU860117 BU741821 CR592122 CB160216 CB159122 BE620320 CB141316 CF264982 GeneLoc Exon Structure 5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MCM3 (see all 13 ) About this scheme ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a · SP1 : - - - SP2 : SP3 : - SP4 : - - - - - - - - - - - - - SP5 : - -
ExUns: 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b SP1 : - - SP2 : - SP3 : SP4 : SP5 :
ECgene alternative splicing isoforms for MCM3
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Expression for MCM3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MCM3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CAGGTCAAGA
About this image MCM3 expression in embryonic tissues and stem cells About this table See MCM3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MCM3 SOURCE GeneReport for Unigene cluster: Hs.179565 SABiosciences Expression via Pathway-Focused PCR Array including MCM3 : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM3
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Orthologsfor MCM3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for MCM3 gene from 9/38 species (see all 38 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves MCM31
minichromosome maintenance complex component 3
77.53(n) 82.4(a)
422043 NM_001006421.1 NP_001006421.1
lizard Reptilia MCM36
--
78(a)
1 ↔ 1
1(122896556-122920981)
African clawed frog Amphibia mcm3-prov2
MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
77.79(n)
BC044051.1
zebrafish Actinopterygii mcm32
MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
78.49(n)
192323 BC056718.1
fruit fly Insecta Mcm31 3
pre-replicative complex formation andmore 3 1
61(a) 3 61.61(n) 1 63.97(a) 1
4F53 31449 1 NM_078493.3 1 NP_511048.2 1
worm Secernentea mcm-33
DNA replication licensing factor MCM3
48(a)
V(15059555-15062189) --
baker's yeast Saccharomycetes MCM3(YEL032W)4 1
Protein involved in DNA replication; component of the more 4 1
54.68(n) 1 54.33(a) 1
5(86937-89852) 4 856680 1, 4 NP_010882.1 1, 4
thale cress eudicotyledons MCM31
DNA replication licensing factor MCM3-like protein
54.58(n) 51.96(a)
834670 NM_123997.2 NP_199440.1
rice Liliopsida Os.233592
Oryza sativa (japonica cultivar-group) cDNA cloneJ more
72.82(n)
AK063430.1
ENSEMBL Gene Tree for MCM3 (if available)TreeFam Gene Tree for MCM3 (if available)
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Paralogsfor MCM3 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MCM3 gene 5 SIMAP similar genes for MCM3 using alignment to 5 protein entries: MCM3_HUMAN (see all proteins ):HCC5 MCM4 FLJ00323 MCM2 MCM7 About GeneDecksing 1 Pseudogenes.org Pseudogene for MCM3 PGOHUM00000234917
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Genomic Variantsfor MCM3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 6 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for MCM3 (52128807 - 52149582 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MCM3: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor MCM3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 602693
OMIM disorders : --17 : About MalaCards cervical cancer cervicitis anaplastic astrocytoma polycystic kidney disease papillary thyroid carcinoma folliculitis kidney disease astrocytoma thyroid carcinoma breast cancer thyroiditis carcinoma melanoma prostate cancer hypoxia prostatitis malaria 6 Novoseek disease relationships for MCM3 gene About this table
Human Genome Epidemiology (HuGE) Navigator: MCM3 (2 documents) Export disorders for MCM3 gene to outside databases
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Publicationsfor MCM3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MCM3 gene, integrated from 9 sources (see all 143 ):(articles sorted by number of sources associating them with MCM3) Utopia : connect your pdf to the dynamic
Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein. (PubMed id 1549468) 1 , 2 , 3(1992) Identification and characterization of a novel component of the human minichromosome maintenance complex. (PubMed id 17296731) 1 , 2 , 9(2007) Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. (PubMed id 15210935) 1 , 2 , 9(2004) A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243) 1 , 2 (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 1 , 2 (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404) 1 , 2 (2003) Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor. (PubMed id 7758114) 1 , 2 (1995) The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins. (PubMed id 8265339) 1 , 2 (1993) Minichromosome maintenance protein 3 is a candidate p roliferation marker in papillary thyroid carcinoma. (PubMed id 19818763) 1 , 9(2010)
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Specialized Databases showing MCM3 gene (According to PharmGKB ,
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About This Section Patent Information for MCM3 gene: MCM3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MCM3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for MCM3 OriGene shRNA RFP for MCM3 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for MCM3 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MCM3 OriGene 3'-UTR Clone for MCM3 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for MCM3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MCM3 OriGene Custom Protein Services for MCM3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MCM3 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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ThermoFisher Antibody for MCM3
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MCM3
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Expression by the Database of Embryonic development, Stem cell research, and
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