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Aliases for MCM3 Gene

Aliases for MCM3 Gene

  • Minichromosome Maintenance Complex Component 3 2 3 5
  • DNA Polymerase Alpha Holoenzyme-Associated Protein P1 3 4
  • RLF Subunit Beta 3 4
  • P1-MCM3 3 4
  • P102 3 4
  • MCM3 Minichromosome Maintenance Deficient 3 (S. Cerevisiae) 2
  • Minichromosome Maintenance Deficient (S. Cerevisiae) 3 2
  • MCM3 Minichromosome Maintenance Deficient 3 3
  • Replication Licensing Factor, Beta Subunit 3
  • Minichromosome Maintenance Deficient 3 3
  • DNA Replication Licensing Factor MCM3 3
  • Cervical Cancer Proto-Oncogene 5 3
  • DNA Replication Factor MCM3 3
  • HRlf Beta Subunit 3
  • EC 3.6.4.12 4
  • HCC5 3
  • P1.H 3
  • RLFB 3

External Ids for MCM3 Gene

Previous GeneCards Identifiers for MCM3 Gene

  • GC06M052130
  • GC06M052175
  • GC06M051960
  • GC06M052128

Summaries for MCM3 Gene

Entrez Gene Summary for MCM3 Gene

  • The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for MCM3 Gene

MCM3 (Minichromosome Maintenance Complex Component 3) is a Protein Coding gene. Diseases associated with MCM3 include Balanitis Xerotica Obliterans. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Mitotic G1-G1/S phases. GO annotations related to this gene include DNA helicase activity and magnesium chelatase activity.

UniProtKB/Swiss-Prot for MCM3 Gene

  • Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.

Gene Wiki entry for MCM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCM3 Gene

Genomics for MCM3 Gene

Regulatory Elements for MCM3 Gene

Enhancers for MCM3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F052388 2.1 VISTA FANTOM5 Ensembl ENCODE 16.9 -105.4 -105380 3.9 HDGF MLX ARID4B FEZF1 ZNF48 YY1 GATA2 CBX5 JUNB REST EFHC1 PAQR8 MCM3 IL17F SLC25A20P1 PIR61259
GH06F052396 1.5 FANTOM5 Ensembl ENCODE 18.9 -114.3 -114344 4.8 ARID4B FEZF1 ZNF2 ZNF48 SLC30A9 ZNF143 TSHZ1 REST PPARG KAT8 MCM3 EFHC1 PAQR8 IL17F SLC25A20P1 PIR61259
GH06F052393 1.3 FANTOM5 Ensembl ENCODE 18.9 -109.4 -109444 1.4 PKNOX1 USF1 WRNIP1 ZIC2 ZBTB40 RELA POLR2A NFYB EED ETV6 EFHC1 MCM3 PAQR8 PIR61259
GH06F052350 1.7 FANTOM5 Ensembl ENCODE 11 -67.3 -67320 3.2 HDGF WRNIP1 ARID4B ZNF2 SLC30A9 CBX5 FOS DEK ZNF263 JUNB PAQR8 MCM3 GC06M052308
GH06F052563 1.7 FANTOM5 Ensembl ENCODE 9.3 -286.3 -286338 14.5 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF207 TRAM2-AS1 EFHC1 MCM3 PAQR8 LOC730101 TRAM2 GC06P052544
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MCM3 on UCSC Golden Path with GeneCards custom track

Promoters for MCM3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001218407 181 2600 HDGF PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for MCM3 Gene

Chromosome:
6
Start:
52,264,009 bp from pter
End:
52,284,881 bp from pter
Size:
20,873 bases
Orientation:
Minus strand

Genomic View for MCM3 Gene

Genes around MCM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCM3 Gene

Proteins for MCM3 Gene

  • Protein details for MCM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25205-MCM3_HUMAN
    Recommended name:
    DNA replication licensing factor MCM3
    Protein Accession:
    P25205
    Secondary Accessions:
    • B4DWW4
    • Q92660
    • Q9BTR3
    • Q9NUE7

    Protein attributes for MCM3 Gene

    Size:
    808 amino acids
    Molecular mass:
    90981 Da
    Quaternary structure:
    • Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (Probable). Associated with the replication-specific DNA polymerase alpha. Interacts with MCMBP. Interacts with ANKRD17.
    Miscellaneous:
    • Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. The MCM2-7 hexamer is the proposed physiological active complex.

    Alternative splice isoforms for MCM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCM3 Gene

Post-translational modifications for MCM3 Gene

  • O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
  • Ubiquitination at Lys 35, Lys 266, Lys 293, Lys 301, Lys 351, Lys 463, Lys 579, Lys 635, and Lys 748
  • Modification sites at PhosphoSitePlus

Other Protein References for MCM3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MCM3 (MCM3)

No data available for DME Specific Peptides for MCM3 Gene

Domains & Families for MCM3 Gene

Gene Families for MCM3 Gene

Graphical View of Domain Structure for InterPro Entry

P25205

UniProtKB/Swiss-Prot:

MCM3_HUMAN :
  • Contains 1 MCM domain.
  • Belongs to the MCM family.
Domain:
  • Contains 1 MCM domain.
Family:
  • Belongs to the MCM family.
genes like me logo Genes that share domains with MCM3: view

Function for MCM3 Gene

Molecular function for MCM3 Gene

GENATLAS Biochemistry:
cell division cycle,early S-phase-like-3,participating in the cell cycle control of genome duplication
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.

Enzyme Numbers (IUBMB) for MCM3 Gene

Gene Ontology (GO) - Molecular Function for MCM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003677 DNA binding IEA --
GO:0003678 DNA helicase activity IEA --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 12364596
genes like me logo Genes that share ontologies with MCM3: view
genes like me logo Genes that share phenotypes with MCM3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCM3 Gene

Localization for MCM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCM3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCM3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5

Gene Ontology (GO) - Cellular Components for MCM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region IDA 19135898
GO:0005634 nucleus IEA,IDA 20531406
GO:0005654 nucleoplasm IDA,TAS --
GO:0005658 alpha DNA polymerase:primase complex TAS 1549468
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MCM3: view

Pathways & Interactions for MCM3 Gene

genes like me logo Genes that share pathways with MCM3: view

Pathways by source for MCM3 Gene

SIGNOR curated interactions for MCM3 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for MCM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0006260 DNA replication IEA,TAS --
GO:0006270 DNA replication initiation IEA --
GO:0007049 cell cycle IEA --
GO:0032508 DNA duplex unwinding IEA --
genes like me logo Genes that share ontologies with MCM3: view

Drugs & Compounds for MCM3 Gene

(4) Drugs for MCM3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for MCM3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MCM3: view

Transcripts for MCM3 Gene

Unigene Clusters for MCM3 Gene

Minichromosome maintenance complex component 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCM3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a ·
SP1: - - -
SP2:
SP3: -
SP4: - - - - - - - - - - - - -
SP5: - -
SP6:
SP7: - - - - - - - - -
SP8:
SP9: - - - -
SP10: - - -
SP11: - -
SP12:
SP13:

ExUns: 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b
SP1: - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for MCM3 Gene

GeneLoc Exon Structure for
MCM3
ECgene alternative splicing isoforms for
MCM3

Expression for MCM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MCM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MCM3 Gene

This gene is overexpressed in Liver (47.6) and Lymph node (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MCM3 Gene



Protein tissue co-expression partners for MCM3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MCM3 Gene:

MCM3

SOURCE GeneReport for Unigene cluster for MCM3 Gene:

Hs.179565
genes like me logo Genes that share expression patterns with MCM3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MCM3 Gene

Orthologs for MCM3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCM3 34 35
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia MCM3 34 35
  • 92.08 (n)
cow
(Bos Taurus)
Mammalia MCM3 34 35
  • 89.48 (n)
mouse
(Mus musculus)
Mammalia Mcm3 34 16 35
  • 88.32 (n)
oppossum
(Monodelphis domestica)
Mammalia MCM3 35
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcm3 34
  • 87.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MCM3 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves MCM3 34 35
  • 77.1 (n)
lizard
(Anolis carolinensis)
Reptilia MCM3 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zmcm3 34
  • 73.06 (n)
African clawed frog
(Xenopus laevis)
Amphibia mcm3-prov 34
zebrafish
(Danio rerio)
Actinopterygii mcm3 34 35 35
  • 71.76 (n)
mcm3l 35
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mcm3 36 34 35
  • 62 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001135 34
  • 61.44 (n)
worm
(Caenorhabditis elegans)
Secernentea mcm-3 36 35
  • 48 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR355C 34
  • 56.02 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCM3 34 35 37
  • 54.69 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22243g 34
  • 53.34 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MCM3 34
  • 54.61 (n)
rice
(Oryza sativa)
Liliopsida Os05g0476200 34
  • 54.93 (n)
Os.23359 34
wheat
(Triticum aestivum)
Liliopsida Ta.14537 34
corn
(Zea mays)
Liliopsida Zm.174 34
bread mold
(Neurospora crassa)
Ascomycetes NCU08009 34
  • 57.87 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mcm3 34
  • 55.28 (n)
Species where no ortholog for MCM3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MCM3 Gene

ENSEMBL:
Gene Tree for MCM3 (if available)
TreeFam:
Gene Tree for MCM3 (if available)

Paralogs for MCM3 Gene

(5) SIMAP similar genes for MCM3 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for MCM3 Gene

genes like me logo Genes that share paralogs with MCM3: view

No data available for Paralogs for MCM3 Gene

Variants for MCM3 Gene

Sequence variations from dbSNP and Humsavar for MCM3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10456156 -- 52,274,621(+) gaggt(C/T)gaggc intron-variant
rs10456658 -- 52,268,933(+) GTTTC(A/G)GAGGA intron-variant
rs10456659 -- 52,272,112(+) AGACA(C/G/T)GTTAT intron-variant
rs10712928 -- 52,286,742(+) GTTAT(-/C)CCCGA upstream-variant-2KB
rs10807441 -- 52,266,456(+) GTTTC(C/T)CCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCM3 Gene

Variant ID Type Subtype PubMed ID
nsv830662 CNV gain 17160897

Variation tolerance for MCM3 Gene

Residual Variation Intolerance Score: 24.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.48; 77.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCM3 Gene

Disorders for MCM3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MCM3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
balanitis xerotica obliterans
  • penile lichen sclerosus
- elite association - COSMIC cancer census association via MalaCards
Search MCM3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MCM3

Genetic Association Database (GAD)
MCM3
Human Genome Epidemiology (HuGE) Navigator
MCM3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCM3
genes like me logo Genes that share disorders with MCM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MCM3 Gene

Publications for MCM3 Gene

  1. Identification and characterization of a novel component of the human minichromosome maintenance complex. (PMID: 17296731) Sakwe A.M. … Frappier L. (Mol. Cell. Biol. 2007) 3 4 22 64
  2. Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. (PMID: 15210935) Cortez D. … Elledge S.J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 22 64
  3. Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein. (PMID: 1549468) Thoemmes P. … Knippers R. (Nucleic Acids Res. 1992) 2 3 4 64
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64
  5. Minichromosome maintenance protein 3 is a candidate proliferation marker in papillary thyroid carcinoma. (PMID: 19818763) Lee Y.S. … Kim J.W. (Exp. Mol. Pathol. 2010) 3 22 64

Products for MCM3 Gene

Sources for MCM3 Gene

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