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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MCM2 Gene

protein-coding   GIFtS: 71
GCID: GC03P127317

Minichromosome Maintenance Complex Component 2

(Previous names: minichromosome maintenance deficient (S. cerevisiae) 2 (mitotin),...)
(Previous symbols: CCNL1, CDCL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Minichromosome Maintenance Complex Component 21 2     MITOTIN2
CDCL11 2 3 5     cdc192
CCNL11 2 3     Cell Devision Cycle-Like 12
Minichromosome Maintenance Protein 2 Homolog2 3     Cyclin-Like 12
Nuclear Protein BM282 3     DNA Replication Licensing Factor MCM22
BM282 3     MCM2 Minichromosome Maintenance Deficient 2, Mitotin2
MCM2 Minichromosome Maintenance Deficient 2, Mitotin (S. Cerevisiae)1     Minichromosome Maintenance Deficient 2 (Mitotin)2
Minichromosome Maintenance Deficient (S. Cerevisiae) 2 (Mitotin)1     EC 3.6.4.123
mitotin1     KIAA00303
D3S31942     

External Ids:    HGNC: 69441   Entrez Gene: 41712   Ensembl: ENSG000000731117   OMIM: 1169455   UniProtKB: P497363   

Export aliases for MCM2 gene to outside databases

Previous GC identifers: GC03P124148 GC03P127476 GC03P128598 GC03P128638 GC03P128799 GC03P124697


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MCM2 Gene:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that
are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM
proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of
replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex
with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is
phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript
variants have been found, but the full-length nature of some variants has not been defined. (provided by RefSeq,
Oct 2012)

GeneCards Summary for MCM2 Gene: 
MCM2 (minichromosome maintenance complex component 2) is a protein-coding gene. Diseases associated with MCM2 include melanoacanthoma, and follicular adenoma, and among its related super-pathways are Activation of the pre-replicative complex and Lagging Strand Synthesis. GO annotations related to this gene include DNA replication origin binding and histone binding. An important paralog of this gene is MCM9.

UniProtKB/Swiss-Prot: MCM2_HUMAN, P49736
Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase
essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active
ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that
a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site
of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute
differentially to the complex helicase activity. Required for the entry in S phase and for cell division

Gene Wiki entry for MCM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MCM2 gene promoter:
         GR   p53   ATF-2   CUTL1   N-Myc   HOXA5   FOXJ2 (long isoform)   c-Jun   FOXJ2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMCM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MCM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21

MCM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCM2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P127317:  view genomic region     (about GC identifiers)

Start:
127,317,066 bp from pter      End:
127,341,279 bp from pter
Size:
24,214 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MCM2_HUMAN, P49736 (See protein sequence)
Recommended Name: DNA replication licensing factor MCM2  
Size: 904 amino acids; 101896 Da
Subunit: Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit
order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (By simililarity). Interacts with DBF4 (By similarity). Interacts with KAT7.
May interact with MCM10
Subcellular location: Nucleus
Miscellaneous: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and
tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in
vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological
active complex
Sequence caution: Sequence=BAA04642.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAA12177.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA47749.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAA47749.1; Type=Frameshift;
Positions=115, 124, 127, 129, 154, 158, 773, 811;
Secondary accessions: Q14577 Q15023 Q8N2V1 Q969W7 Q96AE1 Q9BRM7

Explore the universe of human proteins at neXtProt for MCM2: NX_P49736

Explore proteomics data for MCM2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on Ser-108 by ATR in proliferating cells. Ser-108 proliferation is increased by genotoxic agents.
    Ser-40 is mediated by the CDC7-DBF4 and CDC7-DBF4B complexes, while Ser-53 phosphorylation is only mediated by
    the CDC7-DBF4 complex. Phosphorylation by the CDC7-DBF4 complex during G1/S phase is required for the initiation
    of DNA replication
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49736

  • MCM2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MCM2 Protein Expression
    REFSEQ proteins: NP_004517.2  
    ENSEMBL proteins: 
     ENSP00000265056   ENSP00000420007   ENSP00000419802   ENSP00000418930   ENSP00000417800  
     ENSP00000420528  
    Reactome Protein details: P49736
    Human Recombinant Protein Products for MCM2: 
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    Novus Biologicals MCM2 Protein
    Novus Biologicals MCM2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MCM2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IDA16899510
    GO:0005634nucleus IDA16899510
    GO:0005654nucleoplasm TAS--
    GO:0005664nuclear origin of replication recognition complex IEA--
    GO:0042555MCM complex IDA17296731

    MCM2 for ontologies           About GeneDecksing



    MCM2 Antibody Products: 
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    Abcam antibodies for MCM2
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    ThermoFisher Antibody for MCM2
    LSBio Antibodies in human, mouse, rat for MCM2 

    Assay Products for MCM2: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for MCM2 
    Cloud-Clone Corp. CLIAs for MCM2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR008045 MCM2
     IPR018525 MCM_CS
     IPR012340 NA-bd_OB-fold
     IPR027417 P-loop_NTPase
     IPR001208 MCM_DNA-dep_ATPase

    Graphical View of Domain Structure for InterPro Entry P49736

    ProtoNet protein and cluster: P49736

    2 Blocks protein domains:
    IPB001208 MCM family
    IPB008045 Mini-chromosome maintenance (MCM) protein 2 signature


    UniProtKB/Swiss-Prot: MCM2_HUMAN, P49736
    Similarity: Belongs to the MCM family
    Similarity: Contains 1 MCM domain


    MCM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MCM2_HUMAN, P49736
    Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase
    essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active
    ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that
    a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site
    of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute
    differentially to the complex helicase activity. Required for the entry in S phase and for cell division
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Genatlas biochemistry entry for MCM2:
    cell division cycle,early S-phase-like 1,involved in an early step of DNA replication,participating in the cell
    cycle control of genome duplication

         Enzyme Number (IUBMB): EC 3.6.4.121

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS8175912
    GO:0003678DNA helicase activity IEA--
    GO:0003688DNA replication origin binding IEA--
    GO:0005515protein binding IPI11095689
    GO:0005524ATP binding IEA--
         
    MCM2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MCM2:
     Increased cell death in breast 

         15/17 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mcm2) (see all 17):
     adipose tissue  behavior/neurological  cellular  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  hematopoietic system  immune system  integument 
     mortality/aging  muscle  nervous system  normal  pigmentation 

    MCM2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MCM2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MCM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MCM2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MCM2 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MCM2:
    hsa-mir-1296 (MIRT000473)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCM2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate MCM2:
    hsa-miR-4272
    SwitchGear 3'UTR luciferase reporter plasmidMCM2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MCM2 (NM_004526)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCM2
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MCM2 About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Activation of the pre-replicative complex
    Activation of the pre-replicative complex0.67
    Cell cycle Start of DNA replication in early S phase0.54
    DNA Replication0.67
    2Lagging Strand Synthesis
    DNA strand elongation0.65
    Unwinding of DNA0.35
    DNA replication0.63
    3Mitotic G1-G1/S phases
    Mitotic G1-G1/S phases0.80
    G1 to S cell cycle control0.36
    G1/S Transition0.80
    4Cell cycle Transition and termination of DNA replacation
    Cell cycle Transition and termination of DNA replication0.95
    Cell cycle Transition and termination of DNA replacation0.95
    5Cell cycle
    Cell cycle0.59
    Cell cycle0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for MCM2
        Cell cycle Transition and termination of DNA replacation
    Meiosis
    Cell cycle Start of DNA replication in early S phase

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MCM2
        Cell Cycle Control of Chromosomal Replication

    1 Cell Signaling Technology (CST) Pathway for MCM2
        Cell Cycle / Checkpoint Control

    2 GeneGo (Thomson Reuters) Pathways for MCM2
        Cell cycle Transition and termination of DNA replication
    Cell cycle Start of DNA replication in early S phase

    3 BioSystems Pathways for MCM2
        Cell cycle
    G1 to S cell cycle control
    DNA Replication

    5/21        Reactome Pathways for MCM2 (see all 21)
        Activation of ATR in response to replication stress
    Mitotic G1-G1/S phases
    DNA Replication
    Removal of licensing factors from origins
    Cell Cycle


    2         Kegg Pathways  (Kegg details for MCM2):
        DNA replication
    Cell cycle


    MCM2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MCM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/232 Interacting proteins for MCM2 (P497361, 2, 3 ENSP000002650564) via UniProtKB, MINT, STRING, and/or I2D (see all 232)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4BP628051, 3EBI-374819,EBI-302023 I2D: score=5 
    HIST1H4CP628051, 3EBI-374819,EBI-302023 I2D: score=5 
    HIST1H4DP628051, 3EBI-374819,EBI-302023 I2D: score=5 
    HIST1H4EP628051, 3EBI-374819,EBI-302023 I2D: score=5 
    HIST1H4FP628051, 3EBI-374819,EBI-302023 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006260DNA replication TAS--
    GO:0006268DNA unwinding involved in DNA replication IEA--
    GO:0006270DNA replication initiation IMP16899510

    MCM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MCM2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MCM2

    5 Novoseek inferred chemical compound relationships for MCM2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paraffin 13.4 3 19293805 (1), 15735170 (1), 11839717 (1)
    threonine 0 1 17046832 (1)
    alanine 0 1 17046832 (1)
    estrogen 0 1 14501812 (1)
    serine 0 2 17046832 (1), 16864800 (1)

    Search CenterWatch for drugs/clinical trials and news about MCM2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MCM2 gene: 
    NM_004526.3  

    Unigene Cluster for MCM2:

    Minichromosome maintenance complex component 2
    Hs.477481  [show with all ESTs]
    Unigene Representative Sequence: NR_073375
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265056(uc003ejp.3 uc011bkm.2 uc010hsl.3 uc011bkn.2)
    ENST00000474964 ENST00000480910 ENST00000472731 ENST00000477668 ENST00000468659
    ENST00000491422 ENST00000473785 ENST00000468414
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate MCM2:
    hsa-miR-4272
    SwitchGear 3'UTR luciferase reporter plasmidMCM2 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCM2

    Additional mRNA sequence: 

    AK128291.1 AK299934.1 BC000300.2 BC006165.1 BC007670.2 BC007938.2 BC014272.2 BC017258.2 
    BC017490.1 BC030131.2 BT009734.1 D21063.1 D83987.1 NR_073375.1 X67334.1 

    9 DOTS entries:

    DT.119111  DT.100783511  DT.101960187  DT.100783507  DT.91725754  DT.97855950  DT.120861149  DT.95303402 
    DT.95303406 

    24/362 AceView cDNA sequences (see all 362):

    BC006165 BQ642011 BC000300 BC030131 BE793912 BU556659 BU849550 BE350828 
    BU846411 BG826399 BQ928883 CA440143 AU125477 BU175955 BQ961276 BU855595 
    BE795813 BU855838 AI275174 BC017258 AI253793 BQ056719 BU956534 BG474117 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MCM2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:              -     -                                                                                   -                                       
    SP2:              -     -           -     -     -                                                           -                                       
    SP3:                                                                                                                                                
    SP4:                                                                                                                                                
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for MCM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MCM2 expression in normal human tissues (normalized intensities)      MCM2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGATTATCC
    MCM2 Expression
    About this image


    MCM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
             spinal cord/lateral wall/ventricular layer   
     
     Uterus (Reproductive System)    fully expand to see all 4 entries
             uterus, post-menopause ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Bone Marrow CD105+ Cells   
             mouse/organ system/cardiovascular system   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
             nerve   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 3 entries
             small intestine ; glandular cells   

    See MCM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MCM2

    SOURCE GeneReport for Unigene cluster: Hs.477481
        SABiosciences Expression via Pathway-Focused PCR Arrays including MCM2: 
              Cell Cycle in human mouse rat
              Cancer PathwayFinder in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MCM2 gene from 10/28 species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mcm21 , 5 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) less1, 5 87.32(n)1
    95.58(a)1
      6 (39.64 cM)5
    172161  NM_008564.21  NP_032590.21 
     888834755 
    chicken
    (Gallus gallus)
    Aves MCM21 minichromosome maintenance complex component 2 80.98(n)
    89.74(a)
      416027  NM_001006139.1  NP_001006139.1 
    lizard
    (Anolis carolinensis)
    Reptilia MCM26
    minichromosome maintenance complex component 2
    89(a)
    1 ↔ 1
    2(166209259-166230612)
    African clawed frog
    (Xenopus laevis)
    Amphibia mcm2-prov2 DNA replication licensing factor MCM2 78.03(n)    U44047.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mcm22 MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) less 79.94(n)   192338  BC048026.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mcm21 , 3 pre-replicative complex formation and
    maintenance DNA binding less3
    Minichromosome maintenance 21
    59(a)3
    62.99(n)1
    65.52(a)1
      3 84F63
    409731  NM_057773.31  NP_477121.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mcm-21 , 3 MCM2/3/5 family3
    Protein MCM-21
    53(a)3
    57.36(n)1
    58.7(a)1
      II(12001573-12006508)3
    1748411  NM_001027245.41  NP_001022416.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MCM2(YBL023C)4
    MCM21
    Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex less4
    Mcm2p1
    50.73(n)1
    52.45(a)1
      2(177526-174920)4
    8522581, 4  NP_009530.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MCM21 minichromosome maintenance protein 2 53.68(n)
    52.23(a)
      841056  NM_001198225.1  NP_001185154.1 
    rice
    (Oryza sativa)
    Liliopsida Os.129742 Oryza sativa (japonica cultivar-group) cDNA cloneJ023133N01, full insert sequence less 73.39(n)    AK121422.1 


    ENSEMBL Gene Tree for MCM2 (if available)
    TreeFam Gene Tree for MCM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MCM2 gene
    MCM92  
    6 SIMAP similar genes for MCM2 using alignment to 7 protein entries:     MCM2_HUMAN (see all proteins):
    FLJ00323    MCM9    MCM6    MCM3    MCM7    MCM4

    MCM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/688 SNPs in MCM2 are shown (see all 688)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1115042451,2
    C,F--127315229(+) CCCAGG/AATAAT 2 -- us2k12Minor allele frequency- A:0.04NA 122
    rs1841613871,2
    --127315309(+) CATCCA/GAGGTG 2 -- us2k10--------
    rs175383771,2
    C,F--127315495(+) GGATAT/CGTCCC 2 -- us2k11Minor allele frequency- C:0.01NS 180
    rs1478915851,2
    --127315760(+) GGAGAC/TCAGCC 2 -- us2k10--------
    rs27202621,2
    C,F,A,H--127315788(-) agagaG/Tgggat 2 -- us2k111Minor allele frequency- T:0.44NA NS WA CSA 318
    rs1873230651,2
    --127315828(+) ATGGCA/GTGCAT 2 -- us2k10--------
    rs1416924571,2
    C--127315896(+) GGAGGC/TTGCAG 2 -- us2k10--------
    rs1115898371,2
    C--127315957(+) GTCTC-/AAAAAA 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1470332821,2
    --127316038(+) GGGTCA/CCAGGC 2 -- us2k10--------
    rs174968461,2
    C,F--127316284(+) ATACAG/CAATAG 2 -- us2k11Minor allele frequency- C:0.01NS 180

    HapMap Linkage Disequilibrium report for MCM2 (127317066 - 127341279 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MCM2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2653998CNV Deletion19546169
    esv2102273CNV Deletion18987734
    esv2555442CNV Deletion19546169
    dgv5249n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 116945    OMIM disorders: --

    20/51 diseases for MCM2 (see all 51):    About MalaCards
    melanoacanthoma    follicular adenoma    adenocarcinoma in situ    actinic keratosis
    barrett's esophagus    cervical adenocarcinoma    keratosis    histiocytoma
    fibrous histiocytoma    bladder carcinoma    gastrointestinal stromal tumor    laryngitis
    cervical squamous cell carcinoma    oligodendroglioma    gastric adenocarcinoma    adenocarcinoma
    colon adenocarcinoma    squamous cell carcinoma    transitional cell carcinoma    diffuse large b-cell lymphoma

    2 diseases from the University of Copenhagen DISEASES database for MCM2:
    Cervix endometriosis     Carcinoma

    MCM2 for disorders           About GeneDecksing

    10/19 Novoseek inferred disease relationships for MCM2 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dysplasia 49.2 27 12855631 (6), 11872961 (3), 19116018 (2), 16832409 (2) (see all 9)
    laryngeal squamous cell carcinoma 41 4 16832409 (1), 12966424 (1)
    carcinoma squamous cell 39.3 2 12949987 (1), 16832409 (1)
    adenocarcinoma 39.2 22 18803052 (5), 17940502 (4), 19077563 (2), 19188825 (1) (see all 6)
    adenoma follicular 37.6 1 16722928 (1)
    bladder carcinoma 33.6 3 12565771 (2)
    barrett esophagus 32.3 2 12855631 (1)
    tumors 29.2 36 11948116 (4), 12949987 (3), 18465232 (3), 18774496 (3) (see all 11)
    carcinoma 21.5 10 19293805 (3), 18373176 (3), 17013685 (1), 12966424 (1) (see all 5)
    cancer 19.6 9 18286467 (2), 16545117 (2), 16112007 (1), 18373176 (1) (see all 6)

    Genetic Association Database (GAD): MCM2
    Human Genome Epidemiology (HuGE) Navigator: MCM2 (3 documents)

    Export disorders for MCM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MCM2 gene, integrated from 9 sources (see all 258):
    (articles sorted by number of sources associating them with MCM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21. (PubMed id 8258304)1, 2, 3, 9 Mincheva A.... Lichter P. (1994)
    2. Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells. (PubMed id 16899510)1, 2, 9 Tsuji T....Jiang W. (2006)
    3. Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle. (PubMed id 1710453)1, 3, 9 Todorov I.T....Bibor-Hardy V. (1991)
    4. The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. (PubMed id 11095689)1, 2, 9 Izumi M.... Hanaoka F. (2000)
    5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    6. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    7. Identification and characterization of a novel component of the human minichromosome maintenance complex. (PubMed id 17296731)1, 2 Sakwe A.M....Frappier L. (2007)
    8. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PubMed id 16387653)1, 2 Doyon Y.... Cote J. (2006)
    9. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4171 HGNC: 6944 AceView: MCM2 Ensembl:ENSG00000073111 euGenes: HUgn4171
    ECgene: MCM2 Kegg: 4171 H-InvDB: MCM2

    (According to HUGE)
    About This Section
    HUGE: KIAA0030

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MCM2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MCM2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mcm2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MCM2 gene:
    Search GeneIP for patents involving MCM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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