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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MCM2 Gene

protein-coding GIFtS: 70
GCID: GC03P127317

minichromosome maintenance complex component 2

(Previous names: minichromosome maintenance deficient (S. cerevisiae) 2...)
(Previous symbols: CCNL1, CDCL1)

Explore 53 diseases affiliated with
MCM2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Minichromosome Maintenance Complex Component 2¹ ²		MCM2 Minichromosome Maintenance Deficient 2, Mitotin (S. Cerevisiae)¹
CDCL1¹ ² ³ ⁵		Minichromosome Maintenance Deficient (S. Cerevisiae) 2 (Mitotin)¹
BM28¹ ² ³		MITOTIN²
CCNL1¹ ² ³		Cell Devision Cycle-Like 1²
D3S3194¹ ²		Cyclin-Like 1²
Cdc19¹		DNA Replication Licensing Factor MCM2²
KIAA0030¹ ³		MCM2 Minichromosome Maintenance Deficient 2, Mitotin²
Minichromosome Maintenance Protein 2 Homolog² ³		Minichromosome Maintenance Deficient 2 (Mitotin)²
Nuclear Protein BM28² ³		EC 3.6.4.12³

External Ids:	HGNC: 6944¹	Entrez Gene: 4171²	Ensembl: ENSG00000073111⁷	OMIM: 116945⁵	UniProtKB: P49736³

Export aliases for MCM2 gene to outside databases

Previous GC identifers: GC03P124148 GC03P127476 GC03P128598 GC03P128638 GC03P128799 GC03P124697

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MCM2:

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are

involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a

key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in

the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has

been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by,

protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length

nature of some variants has not been defined. (provided by RefSeq, Oct 2012)

UniProtKB/Swiss-Prot: MCM2_HUMAN, P49736

Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential

for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in

the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure

of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the

adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex

helicase activity. Required for the entry in S phase and for cell division

Gene Wiki entry for MCM2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MCM2 gene promoter:
GR p53 ATF-2 CUTL1 N-Myc HOXA5 FOXJ2 (long isoform) c-Jun FOXJ2 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MCM2 promoter sequence

Search SABiosciences Chromatin IP Primers for MCM2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCM2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21 Ensembl cytogenetic band: 3q21.3 HGNC cytogenetic band: 3q21

MCM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCM2 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P127317: view genomic region (about GC identifiers)

Start:	127,317,066 bp from pter	End:	127,341,279 bp from pter
Size:	24,214 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MCM2_HUMAN, P49736 (See protein sequence)

Recommended Name: DNA replication licensing factor MCM2

Size: 904 amino acids; 101896 Da

Subunit: Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order

MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (By simililarity). Interacts with DBF4 (By similarity). Interacts with KAT7. May

interact with MCM10

Subcellular location: Nucleus

Miscellaneous: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric

complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase

activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex

Sequence caution: Sequence=BAA04642.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Sequence=BAA12177.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA47749.1;

Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAA47749.1; Type=Frameshift;

Positions=115, 124, 127, 129, 154, 158, 773, 811;

Secondary accessions: Q14577 Q15023 Q8N2V1 Q969W7 Q96AE1 Q9BRM7

Explore the universe of human proteins at neXtProt for MCM2: NX_P49736

Post-translational modifications:

Phosphorylated on Ser-108 by ATR in proliferating cells. Ser-108 proliferation is increased by genotoxic agents. Ser-40

is mediated by the CDC7-DBF4 and CDC7-DBF4B complexes, while Ser-53 phosphorylation is only mediated by the CDC7-DBF4

complex. Phosphorylation by the CDC7-DBF4 complex during G1/S phase is required for the initiation of DNA replication¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P49736

MCM2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004517.2

ENSEMBL proteins:

ENSP00000265056 ENSP00000420007 ENSP00000419802 ENSP00000418930 ENSP00000417800

ENSP00000420528

Reactome Protein details: P49736
Human Recombinant Protein Products for MCM2:

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	Novus Biologicals MCM2 Protein Novus Biologicals MCM2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MCM2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000785	chromatin	IDA	16899510
GO:0005634	nucleus	IDA	16899510
GO:0005654	nucleoplasm	TAS	--
GO:0005664	nuclear origin of replication recognition complex	IEA	--
GO:0042555	MCM complex	IDA	17296731

MCM2 for ontologies About GeneDecksing

MCM2 Antibody Products:

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	Cell Signaling Technology (CST) Antibodies for MCM2
	OriGene Antibodies (see all 7): MCM2 OriGene Custom Antibody Services for MCM2
	GenScript Custom Superior Antibodies Services for MCM2
	Novus Biologicals MCM2 Antibodies
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	ThermoFisher Antibody for MCM2

Assay Products for MCM2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MCM2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MCM2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MCM2 for domains About GeneDecksing

4 InterPro domains/families:

IPR008045 MCM2

IPR018525 MCM_CS

IPR012340 NA-bd_OB-fold

IPR001208 MCM_DNA-dep_ATPase

Graphical View of Domain Structure for InterPro Entry P49736

ProtoNet protein and cluster: P49736

2 Blocks protein families:

IPB001208 MCM family

IPB008045 Mini-chromosome maintenance (MCM) protein 2 signature

UniProtKB/Swiss-Prot: MCM2_HUMAN, P49736

Similarity: Belongs to the MCM family

Similarity: Contains 1 MCM domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MCM2_HUMAN, P49736

Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential

for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in

the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure

of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the

adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex

helicase activity. Required for the entry in S phase and for cell division

Catalytic activity: ATP + H(2)O = ADP + phosphate

Genatlas biochemistry entry for MCM2:

cell division cycle,early S-phase-like 1,involved in an early step of DNA replication,participating in the cell cycle

control of genome duplication

Enzyme Number (IUBMB): EC 3.6.4.12¹

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	TAS	8175912
GO:0003688	DNA replication origin binding	IEA	--
GO:0004386	helicase activity	IEA	--
GO:0005515	protein binding	IPI	16387653
GO:0005524	ATP binding	IEA	--

MCM2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for MCM2:

Increased cell death in breast

15/17 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Mcm2) (see all 17):

adipose tissue	behavior/neurological	cellular	digestive/alimentary	embryogenesis
endocrine/exocrine gland	growth/size	hematopoietic system	immune system	integument
mortality/aging	muscle	nervous system	normal	pigmentation

MCM2 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MCM2

miRNA Products:		miRTarBase miRNAs that target MCM2: hsa-mir-1296 (MIRT000473)

		OriGene 3'-UTR Clone: MCM2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCM2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate MCM2:
		hsa-miR-4272
		SwitchGear 3'UTR luciferase reporter plasmid: MCM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCM2 (see all 7) OriGene shRNA RFP: MCM2 OriGene siRNA: MCM2
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		Sirion Biotech Custom design and validation of potent shRNA sequences against MCM2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MCM2
			Sirion Biotech Customized adenovirus for overexpression of MCM2 Sirion Biotech Customized adenovirus for potent knockdown of MCM2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCM2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCM2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MCM2 (NM_004526)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCM2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCM2

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/11 pathways (see all 11)
Assembly of the pre-replicative complex	0.77	M/G1 Transition	0.62
Switching of origins to a post-replicative state	0.70	Synthesis of DNA	0.51
Orc1 removal from chromatin	0.70	DNA Replication	0.49
Regulation of DNA replication	0.68	Cell Cycle Checkpoints	0.42

Cell cycle

	Cell cycle	1.00			G1 to S cell cycle control	0.38
	Cell cycle	0.57

Lagging Strand Synthesis

	DNA strand elongation	0.65			Unwinding of DNA	0.00
	DNA replication	0.56

Cell cycle_Start of DNA replication in early S phase

Cell cycle_Start of DNA replication in early S phase

1.00

Cell cycle Start of DNA replication in early S phase

0.98

Activation of ATR in response to replication stress

Activation of ATR in response to replication stress

1.00

G2/M Checkpoints

0.86

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for MCM2

	Cell cycle Transition and termination of DNA replacation
	Meiosis
	Cell cycle Start of DNA replication in early S phase

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MCM2

Cell Cycle Control of Chromosomal Replication

1 Cell Signaling Technology (CST) Pathway for MCM2

Cell Cycle / Checkpoint Control

2 GeneGo (Thomson Reuters) Pathways for MCM2

	Cell cycle Transition and termination of DNA replication
	Cell cycle Start of DNA replication in early S phase

3 BioSystems Pathways for MCM2

	Cell cycle
	G1 to S cell cycle control
	DNA Replication

5/21 Reactome Pathways for MCM2 (see all 21)

	Activation of ATR in response to replication stress
	Mitotic G1-G1/S phases
	DNA Replication
	Removal of licensing factors from origins
	Cell Cycle

2 Kegg Pathways (Kegg details for MCM2):

	DNA replication
	Cell cycle

MCM2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MCM2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/223 Interacting proteins for MCM2 (P49736^{1, 2, 3} ENSP00000265056⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 223)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4B	P62805¹^,³	EBI-374819,EBI-302023 I2D: score=5
HIST1H4C	P62805¹^,³	EBI-374819,EBI-302023 I2D: score=5
HIST1H4D	P62805¹^,³	EBI-374819,EBI-302023 I2D: score=5
HIST1H4E	P62805¹^,³	EBI-374819,EBI-302023 I2D: score=5
HIST1H4F	P62805¹^,³	EBI-374819,EBI-302023 I2D: score=5

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000084	S phase of mitotic cell cycle	TAS	--
GO:0000216	M/G1 transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--

MCM2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MCM2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MCM2
5 Novoseek chemical compound relationships for MCM2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
paraffin	13.4	3	19293805 (1), 15735170 (1), 11839717 (1)
threonine	0	1	17046832 (1)
alanine	0	1	17046832 (1)
estrogen	0	1	14501812 (1)
serine	0	2	17046832 (1), 16864800 (1)

Search CenterWatch for drugs/clinical trials and news about MCM2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MCM2 gene:

NM_004526.3

Unigene Cluster for MCM2:

Minichromosome maintenance complex component 2

Hs.477481 [show with all ESTs]

Unigene Representative Sequence: NR_073375

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000265056(uc003ejp.3 uc011bkm.2 uc010hsl.3 uc011bkn.2)

ENST00000474964 ENST00000480910 ENST00000472731 ENST00000477668 ENST00000468659

ENST00000491422 ENST00000473785 ENST00000468414

miRNA Products:		OriGene 3'-UTR Clone: MCM2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCM2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate MCM2:
		hsa-miR-4272
		SwitchGear 3'UTR luciferase reporter plasmid: MCM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCM2 (see all 7) OriGene shRNA RFP: MCM2 OriGene siRNA: MCM2
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		Sirion Biotech Custom design and validation of potent shRNA sequences against MCM2

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		GenScript: all cDNA clones in your preferred vector: MCM2 (NM_004526)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCM2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCM2

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCM2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCM2

Additional cDNA sequence:

AK128291.1 AK299934.1 BC000300.2 BC006165.1 BC007670.2 BC007938.2 BC014272.2 BC017258.2

BC017490.1 BC030131.2 BT009734.1 D21063.1 D83987.1 NR_073375.1 X67334.1

9 DOTS entries:

DT.119111 DT.100783511 DT.101960187 DT.100783507 DT.91725754 DT.97855950 DT.120861149 DT.95303402

DT.95303406

24/362 AceView cDNA sequences (see all 362):

AW571876 BU844473 AW273210 BE543214 BU846411 BM825182 CB120308 BC017490

CR605781 BC000300 BE207696 BG826399 BM551685 BQ324881 AL120980 CD675726

AI498876 BC006165 BU846035 BQ065659 BM467183 AU125477 BU556458 BQ642011

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for MCM2 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16	^	17	^	18a	·	18b
SP1:					-		-																												-
SP2:					-		-				-		-		-																				-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for MCM2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MCM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGGATTATCC

About this image

MCM2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Brain

Medulla Oblongata

Brain

Neural Tube

Diencephalic Ventricular Zone

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Telencephalon

Neural Tube

Spinal Cord

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

See MCM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MCM2

SOURCE GeneReport for Unigene cluster: Hs.477481

SABiosciences Expression via Pathway-Focused PCR Arrays including MCM2:

Cell Cycle in human mouse rat

Cancer PathwayFinder in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MCM2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MCM2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCM2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCM2

In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for MCM2 gene from 9/40 species (see all 40) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MCM2¹	minichromosome maintenance complex component 2	80.98(n) 89.74(a)		416027 NM_001006139.1 NP_001006139.1
lizard (Anolis carolinensis)	Reptilia	MCM2⁶	--	88(a)	1 ↔ 1	2(166210719-166230020)
African clawed frog (Xenopus laevis)	Amphibia	mcm2-prov²	DNA replication licensing factor MCM2	78.03(n)		U44047.1
zebrafish (Danio rerio)	Actinopterygii	mcm2²	MCM2 minichromosome maintenance deficient 2, mitotin more	79.94(n)		192338 BC048026.1
fruit fly (Drosophila melanogaster)	Insecta	Mcm2^{1 , 3}	pre-replicative complex formation and maintenance more³ Minichromosome maintenance 2¹	59(a)³ 62.99(n)¹ 65.52(a)¹		3 84F6³ 40973¹ NM_057773.3¹ NP_477121.1¹
worm (Caenorhabditis elegans)	Secernentea	mcm-2^{1 , 3}	MCM2/3/5 family³ Protein MCM-2¹	53(a)³ 57.36(n)¹ 58.7(a)¹		II(12001573-12006508)³ 174841¹ NM_001027245.4¹ NP_001022416.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	MCM2(YBL023C)⁴ MCM2¹	Protein involved in DNA replication; component of the more⁴ Mcm2p¹	50.73(n)¹ 52.45(a)¹		2(177526-174920)⁴ 852258^{1, 4} NP_009530.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	MCM2¹	minichromosome maintenance protein 2	53.68(n) 52.23(a)		841056 NM_001198225.1 NP_001185154.1
rice (Oryza sativa)	Liliopsida	Os.12974²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	73.39(n)		AK121422.1

ENSEMBL Gene Tree for MCM2 (if available)
TreeFam Gene Tree for MCM2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for MCM2 gene

MCM9²

8 SIMAP similar genes for MCM2 using alignment to 7 protein entries: MCM2_HUMAN (see all proteins):

FLJ00323 MCM9 MCM6 MCM3 MCM4 MCM7

MCM5 HCC5

MCM2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111504245^1,2	C	--	127315229(+)	`CCCAGG/AATAAT`	2	--	us2k¹		2		NA	122
rs184161387^1,2		--	127315309(+)	`CATCCA/GAGGTG`	2	--	us2k¹		0	--	--	--	--
rs17538377^1,2	C	--	127315495(+)	`GGATAT/CGTCCC`	2	--	us2k¹		1		NS	180
rs147891585^1,2		--	127315760(+)	`GGAGAC/TCAGCC`	2	--	us2k¹		0	--	--	--	--
rs2720262^1,2	C,F,A,H	--	127315788(-)	`AGAGAG/TGGGAT`	2	--	us2k¹		11		NA NS WA CSA	318
rs187323065^1,2		--	127315828(+)	`ATGGCA/GTGCAT`	2	--	us2k¹		0	--	--	--	--
rs141692457^1,2		--	127315896(+)	`GGAGGC/TTGCAG`	2	--	us2k¹		0	--	--	--	--
rs111589837^1,2	C	--	127315957(+)	`GTCTC-/AAAAAA`	2	--	us2k¹		1		CSA	2
rs147033282^1,2		--	127316038(+)	`GGGTCA/CCAGGC`	2	--	us2k¹		0	--	--	--	--
rs17496846^1,2	C,F	--	127316284(+)	`ATACAG/CAATAG`	2	--	us2k¹		1		NS	180

HapMap Linkage Disequilibrium report for MCM2 (127317066 - 127341279 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MCM2
2 Indels: 46288 98440

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MCM2 for disorders           About GeneDecksing

OMIM gene information: 116945    OMIM disorders: --

20/53 diseases for MCM2 (see all 53):    About MalaCards

diffuse large b-cell lymphoma fibrous histiocytoma b-cell lymphomas barrett's esophagus

laryngeal squamous cell carcinoma malignant fibrous histiocytoma actinic keratosis squamous cell carcinoma

gastrointestinal stromal tumor histiocytoma esophageal squamous cell carcinoma inflammatory bowel disease

keratosis transitional cell carcinoma basal cell carcinoma follicular adenoma

bladder carcinoma pituitary adenoma laryngitis carcinoma

3 diseases from the University of Copenhagen DISEASES database for MCM2:

Carcinoma Cervix endometriosis Melanoacanthoma

10/19 Novoseek disease relationships for MCM2 gene (see all 19) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dysplasia	49.2	27	12855631 (6), 11872961 (3), 19116018 (2), 16832409 (2) (see all 9)
laryngeal squamous cell carcinoma	41	4	16832409 (1), 12966424 (1)
carcinoma squamous cell	39.3	2	12949987 (1), 16832409 (1)
adenocarcinoma	39.2	22	18803052 (5), 17940502 (4), 19077563 (2), 19188825 (1) (see all 6)
adenoma follicular	37.6	1	16722928 (1)
bladder carcinoma	33.6	3	12565771 (2)
barrett esophagus	32.3	2	12855631 (1)
tumors	29.2	36	11948116 (4), 12949987 (3), 18465232 (3), 18774496 (3) (see all 11)
carcinoma	21.5	10	19293805 (3), 18373176 (3), 17013685 (1), 12966424 (1) (see all 5)
cancer	19.6	9	18286467 (2), 16545117 (2), 16112007 (1), 18373176 (1) (see all 6)

Human Genome Epidemiology (HuGE) Navigator: MCM2 (3 documents)

Export disorders for MCM2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MCM2 gene, integrated from 9 sources (see all 245):
(articles sorted by number of sources associating them with MCM2)

Utopia: connect your pdf to the dynamic
world of online information

The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21. (PubMed id 8258304)^{1, 2, 3, 9} Mincheva A.... Lichter P. (1994)
Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells. (PubMed id 16899510)^{1, 2, 9} Tsuji T....Jiang W. (2006)
Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle. (PubMed id 1710453)^{1, 3, 9} Todorov I.T....Bibor-Hardy V. (1991)
The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. (PubMed id 11095689)^{1, 2, 9} Izumi M.... Hanaoka F. (2000)
Identification and characterization of a novel component of the human minichromosome maintenance complex. (PubMed id 17296731)^{1, 2} Sakwe A.M....Frappier L. (2007)
ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PubMed id 16387653)^{1, 2} Doyon Y.... Cote J. (2006)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. (PubMed id 15210935)^{1, 2} Cortez D.... Elledge S.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4171	HGNC: 6944	AceView: MCM2	Ensembl:ENSG00000073111	euGenes: HUgn4171
ECgene: MCM2	Kegg: 4171	H-InvDB: MCM2

(According to HUGE)
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HUGE: KIAA0030

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MCM2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MCM2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mcm2/

Intellectual Property for MCM2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MCM2 gene:
Search GeneIP for patents involving MCM2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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MCM2 Gene

minichromosome maintenance complex component 2

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MCM2 Gene

minichromosome maintenance complex component 2

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