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Aliases for MCM2 Gene

Aliases for MCM2 Gene

  • Minichromosome Maintenance Complex Component 2 2 3 5
  • Minichromosome Maintenance Protein 2 Homolog 3 4
  • Nuclear Protein BM28 3 4
  • CCNL1 3 4
  • CDCL1 3 4
  • BM28 3 4
  • MCM2 Minichromosome Maintenance Deficient 2, Mitotin (S. Cerevisiae) 2
  • Minichromosome Maintenance Deficient (S. Cerevisiae) 2 (Mitotin) 2
  • MCM2 Minichromosome Maintenance Deficient 2, Mitotin 3
  • Minichromosome Maintenance Deficient 2 (Mitotin) 3
  • Cell Devision Cycle-Like 1 3
  • Cyclin-Like 1 3
  • EC 3.6.4.12 4
  • KIAA0030 4
  • Mitotin 2
  • D3S3194 3
  • MITOTIN 3
  • Cdc19 3

External Ids for MCM2 Gene

Previous HGNC Symbols for MCM2 Gene

  • CCNL1
  • CDCL1

Previous GeneCards Identifiers for MCM2 Gene

  • GC03P124148
  • GC03P127476
  • GC03P128598
  • GC03P128638
  • GC03P128799
  • GC03P127317
  • GC03P124697

Summaries for MCM2 Gene

Entrez Gene Summary for MCM2 Gene

  • The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]

GeneCards Summary for MCM2 Gene

MCM2 (Minichromosome Maintenance Complex Component 2) is a Protein Coding gene. Diseases associated with MCM2 include cervix endometriosis and follicular adenoma. Among its related pathways are Cell cycle and DNA strand elongation. GO annotations related to this gene include ATPase activity and DNA helicase activity. An important paralog of this gene is MCM9.

UniProtKB/Swiss-Prot for MCM2 Gene

  • Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.

Gene Wiki entry for MCM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCM2 Gene

Genomics for MCM2 Gene

Regulatory Elements for MCM2 Gene

Enhancers for MCM2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MCM2 on UCSC Golden Path with GeneCards custom track

Promoters for MCM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MCM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MCM2 Gene

Chromosome:
3
Start:
127,598,223 bp from pter
End:
127,622,436 bp from pter
Size:
24,214 bases
Orientation:
Plus strand

Genomic View for MCM2 Gene

Genes around MCM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCM2 Gene

Proteins for MCM2 Gene

  • Protein details for MCM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49736-MCM2_HUMAN
    Recommended name:
    DNA replication licensing factor MCM2
    Protein Accession:
    P49736
    Secondary Accessions:
    • Q14577
    • Q15023
    • Q8N2V1
    • Q969W7
    • Q96AE1
    • Q9BRM7

    Protein attributes for MCM2 Gene

    Size:
    904 amino acids
    Molecular mass:
    101896 Da
    Quaternary structure:
    • Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (Probable). Interacts with DBF4 (By similarity). Interacts with KAT7. May interact with MCM10.
    Miscellaneous:
    • Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.
    SequenceCaution:
    • Sequence=BAA04642.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA12177.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA47749.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA47749.1; Type=Frameshift; Positions=115, 124, 127, 129, 154, 158, 773, 811; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MCM2 Gene

neXtProt entry for MCM2 Gene

Proteomics data for MCM2 Gene at MOPED

Post-translational modifications for MCM2 Gene

  • Phosphorylated on Ser-108 by ATR in proliferating cells. Ser-108 proliferation is increased by genotoxic agents. Ser-40 is mediated by the CDC7-DBF4 and CDC7-DBF4B complexes, while Ser-53 phosphorylation is only mediated by the CDC7-DBF4 complex. Phosphorylation by the CDC7-DBF4 complex during G1/S phase is required for the initiation of DNA replication.
  • Ubiquitination at Lys 178, Lys 469, Lys 476, Lys 492, Lys 613, and Lys 722
  • Modification sites at PhosphoSitePlus

Other Protein References for MCM2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MCM2 (MCM2)

No data available for DME Specific Peptides for MCM2 Gene

Domains & Families for MCM2 Gene

Gene Families for MCM2 Gene

Suggested Antigen Peptide Sequences for MCM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49736

UniProtKB/Swiss-Prot:

MCM2_HUMAN :
  • Contains 1 MCM domain.
  • Belongs to the MCM family.
Domain:
  • Contains 1 MCM domain.
Family:
  • Belongs to the MCM family.
genes like me logo Genes that share domains with MCM2: view

Function for MCM2 Gene

Molecular function for MCM2 Gene

GENATLAS Biochemistry:
cell division cycle,early S-phase-like 1,involved in an early step of DNA replication,participating in the cell cycle control of genome duplication
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.

Enzyme Numbers (IUBMB) for MCM2 Gene

Gene Ontology (GO) - Molecular Function for MCM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003688 DNA replication origin binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MCM2: view
genes like me logo Genes that share phenotypes with MCM2: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCM2 Gene

Localization for MCM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCM2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCM2 Gene COMPARTMENTS Subcellular localization image for MCM2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MCM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IDA 16899510
GO:0005664 nuclear origin of replication recognition complex IEA --
GO:0005737 cytoplasm IDA --
GO:0042555 MCM complex IEA,IDA 17296731
genes like me logo Genes that share ontologies with MCM2: view

Pathways & Interactions for MCM2 Gene

genes like me logo Genes that share pathways with MCM2: view

Pathways by source for MCM2 Gene

SIGNOR curated interactions for MCM2 Gene

Activates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for MCM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0006270 DNA replication initiation IEA,IMP 16899510
GO:0006271 DNA strand elongation involved in DNA replication TAS --
GO:0071353 cellular response to interleukin-4 IEA --
genes like me logo Genes that share ontologies with MCM2: view

Drugs & Compounds for MCM2 Gene

(5) Drugs for MCM2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(4) Additional Compounds for MCM2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with MCM2: view

Transcripts for MCM2 Gene

Unigene Clusters for MCM2 Gene

Minichromosome maintenance complex component 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MCM2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - - -
SP2: - - - - - -
SP3:
SP4:
SP5:

Relevant External Links for MCM2 Gene

GeneLoc Exon Structure for
MCM2
ECgene alternative splicing isoforms for
MCM2

Expression for MCM2 Gene

mRNA expression in normal human tissues for MCM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MCM2 Gene

This gene is overexpressed in Liver (39.1), Lymph node (7.1), and Fetal ovary (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCM2 Gene



SOURCE GeneReport for Unigene cluster for MCM2 Gene Hs.477481

genes like me logo Genes that share expression patterns with MCM2: view

Protein tissue co-expression partners for MCM2 Gene

- Elite partner

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MCM2 Gene

Orthologs for MCM2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MCM2 35
  • 85.89 (n)
  • 91.2 (a)
MCM2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCM2 35
  • 89.95 (n)
  • 96.66 (a)
MCM2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcm2 35
  • 87.32 (n)
  • 95.58 (a)
Mcm2 16
Mcm2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MCM2 35
  • 99.56 (n)
  • 100 (a)
MCM2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcm2 35
  • 86.91 (n)
  • 96.13 (a)
oppossum
(Monodelphis domestica)
Mammalia MCM2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCM2 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves MCM2 35
  • 81.11 (n)
  • 90.07 (a)
MCM2 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCM2 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mcm2 35
  • 75.16 (n)
  • 88.67 (a)
Str.1626 35
African clawed frog
(Xenopus laevis)
Amphibia mcm2-prov 35
zebrafish
(Danio rerio)
Actinopterygii mcm2 35
  • 74.81 (n)
  • 83.53 (a)
mcm2 36
  • 84 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7968 35
fruit fly
(Drosophila melanogaster)
Insecta Mcm2 37
  • 59 (a)
Mcm2 35
  • 62.91 (n)
  • 65.48 (a)
Mcm2 36
  • 64 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004275 35
  • 63.58 (n)
  • 65.74 (a)
worm
(Caenorhabditis elegans)
Secernentea mcm-2 37
  • 53 (a)
mcm-2 35
  • 57.36 (n)
  • 59.22 (a)
mcm-2 36
  • 55 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR178W 35
  • 55.48 (n)
  • 53.66 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F12584g 35
  • 52.48 (n)
  • 54.34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCM2 35
  • 51.96 (n)
  • 54.13 (a)
MCM2 36
  • 46 (a)
OneToMany
MCM2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons MCM2 35
  • 54.2 (n)
  • 52.52 (a)
soybean
(Glycine max)
eudicotyledons Gma.2371 35
barley
(Hordeum vulgare)
Liliopsida Hv.3981 35
rice
(Oryza sativa)
Liliopsida Os.12974 35
Os11g0484300 35
  • 56.54 (n)
  • 54.76 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2860 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.647 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04327 35
  • 58.69 (n)
  • 55.24 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mcm2 35
  • 53.37 (n)
  • 56.17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToOne
Species with no ortholog for MCM2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MCM2 Gene

ENSEMBL:
Gene Tree for MCM2 (if available)
TreeFam:
Gene Tree for MCM2 (if available)

Paralogs for MCM2 Gene

Paralogs for MCM2 Gene

(6) SIMAP similar genes for MCM2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MCM2: view

Variants for MCM2 Gene

Sequence variations from dbSNP and Humsavar for MCM2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs3087450 - 127,608,466(+) AGGAC(A/G)CCATT nc-transcript-variant, reference, missense
rs2307311 - 127,618,067(+) ACACC(A/G)TGGAC nc-transcript-variant, reference, missense
rs2307313 - 127,619,192(+) TCTAC(A/G)CCAAG nc-transcript-variant, reference, missense
rs3087452 - 127,599,515(+) GAGGA(G/T)GGAGA nc-transcript-variant, reference, missense
rs2307314 - 127,604,774(+) GTGGG(C/T)TCCTG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MCM2 Gene

Variant ID Type Subtype PubMed ID
dgv5249n71 CNV Loss 21882294
esv2653998 CNV Deletion 19546169
esv2102273 CNV Deletion 18987734
esv2555442 CNV Deletion 19546169

Variation tolerance for MCM2 Gene

Residual Variation Intolerance Score: 8.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.27; 62.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCM2 Gene

HapMap Linkage Disequilibrium report
MCM2
Human Gene Mutation Database (HGMD)
MCM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCM2 Gene

Disorders for MCM2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for MCM2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cervix endometriosis
  • cervical endometriosis
follicular adenoma
  • follicular adenoma of the thyroid gland
melanoacanthoma
adenocarcinoma in situ
barrett esophagus/esophageal adenocarcinoma
  • esophageal cancer
- elite association - COSMIC cancer census association via MalaCards
Search MCM2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MCM2

Genetic Association Database (GAD)
MCM2
Human Genome Epidemiology (HuGE) Navigator
MCM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCM2
genes like me logo Genes that share disorders with MCM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MCM2 Gene

Publications for MCM2 Gene

  1. The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21. (PMID: 8258304) Mincheva A. … Lichter P. (Cytogenet. Cell Genet. 1994) 2 3 4 23 67
  2. Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle. (PMID: 1710453) Todorov I.T. … Bibor-Hardy V. (Biochem. Biophys. Res. Commun. 1991) 2 3 23
  3. Clinical significance of MCM-2 and MCM-5 expression in colon cancer: association with clinicopathological parameters and tumor proliferative capacity. (PMID: 18465232) Giaginis C. … Theocharis S. (Dig. Dis. Sci. 2009) 3 23
  4. mRNA expression of minichromosome maintenance 2 in colonic adenoma and adenocarcinoma. (PMID: 19077563) Wang Y. … Zhou Z.G. (Eur. J. Cancer Prev. 2009) 3 23
  5. Minichromosome maintenance protein-2-positive portal tract lymphocytes distinguish acute cellular rejection from hepatitis C virus recurrence after liver transplantation. (PMID: 19243005) Unitt E. … Alexander G.J. (Liver Transpl. 2009) 3 23

Products for MCM2 Gene

Sources for MCM2 Gene

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