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MCM10 Gene

protein-coding   GIFtS: 59
GCID: GC10P013203

Minichromosome Maintenance Complex Component 10

(Previous name: MCM10 minichromosome maintenance deficient 10 (S. cerevisiae))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Minichromosome Maintenance Complex Component 101 2     hsMCM102
CNA432 5     MCM10 Minichromosome Maintenance Deficient 102
MCM10 Minichromosome Maintenance Deficient 10 (S. Cerevisiae)1     Protein MCM10 Homolog2
DNA432     HsMCM103
Homolog Of Yeast MCM102     

External Ids:    HGNC: 180431   Entrez Gene: 553882   Ensembl: ENSG000000653287   OMIM: 6093575   UniProtKB: Q7L5903   

Export aliases for MCM10 gene to outside databases

Previous GC identifers: GC10P013185 GC10P013353 GC10P013207 GC10P013243 GC10P013116


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MCM10 Gene:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that
are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM
proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of
replication forks and in the recruitment of other DNA replication related proteins. This protein can interact
with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and
phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the
chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin
unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. (provided
by RefSeq, Jul 2008)

GeneCards Summary for MCM10 Gene:
MCM10 (minichromosome maintenance complex component 10) is a protein-coding gene. Diseases associated with MCM10 include rothmund-thomson syndrome, and dilated cardiomyopathy. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot: MCM10_HUMAN, Q7L590
Function: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase
alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage
during replication

Gene Wiki entry for MCM10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MCM10 gene promoter:
         Max1   SRF   AML1a   SRF (504 AA)   Pax-2   MIF-1   FOXO4   Cart-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMCM10 promoter sequence
   Search Chromatin IP Primers for MCM10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MCM10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p13   Ensembl cytogenetic band:  10p13   HGNC cytogenetic band: 10p13

MCM10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCM10 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P013203:  view genomic region     (about GC identifiers)

Start:
13,203,554 bp from pter      End:
13,253,104 bp from pter
Size:
49,551 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MCM10_HUMAN, Q7L590 (See protein sequence)
Recommended Name: Protein MCM10 homolog  
Size: 875 amino acids; 98183 Da
Subunit: Self-associates (By similarity). Interacts with ORC2. May interact with MCM2 and MCM6. Interacts with the
DNA polymerase alpha subunit POLA1. Interacts with RECQL4; this interaction regulates RECQL4 unwinding activity.
Interacts with WDHD1
Developmental stage: Expression is cell cycle regulated. Expression increases at the G1/S-boundary. Expression
decreases in late M phase, remains low during G(1) phase, and starts to accumulate at the onset of S phase
Sequence caution: Sequence=AAF69623.1; Type=Erroneous initiation;
Secondary accessions: A8K9I6 B7ZKZ8 Q3MIR3 Q7LD55 Q96GX4 Q96NB6 Q9H0D7 Q9H3P9 Q9P177
Alternative splicing: 2 isoforms:  Q7L590-1   Q7L590-2   

Explore the universe of human proteins at neXtProt for MCM10: NX_Q7L590

Explore proteomics data for MCM10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys313, Lys627
  • Modification sites at PhosphoSitePlus

  • See MCM10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_060988.3  NP_877428.1  

    ENSEMBL proteins: 
     ENSP00000367986   ENSP00000417094   ENSP00000418268   ENSP00000367966  
    Reactome Protein details: Q7L590

    MCM10 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR015411 Rep_factor_Mcm10
     IPR015408 Znf_Mcm10/DnaG

    Graphical View of Domain Structure for InterPro Entry Q7L590

    ProtoNet protein and cluster: Q7L590

    UniProtKB/Swiss-Prot: MCM10_HUMAN, Q7L590
    Domain: Each zinc finger-like domain binds a zinc ion and is involved in both ssDNA and dsDNA binding, as is the
    OB-fold domain (By similarity)
    Domain: The N-terminal domain mediates homodimerization (By similarity)
    Similarity: Belongs to the MCM10 family


    MCM10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MCM10_HUMAN, Q7L590
    Function: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase
    alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage
    during replication

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI11095689
    GO:0042802identical protein binding IPI17823614
    GO:0046872metal ion binding IEA--
         
    MCM10 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for MCM10:
     Bright nuclei  Increased S DNA content, incre  Increased cell number in G2M,   Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mcm10):
     cellular  embryogenesis  mortality/aging 

    MCM10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mcm10tm1Hlee for MCM10

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MCM10
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MCM10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MCM10

    miRNA
    Products:
        
    miRTarBase miRNAs that target MCM10:
    hsa-mir-24-3p (MIRT030381), hsa-mir-615-3p (MIRT039760), hsa-mir-192-5p (MIRT004854), hsa-mir-215-5p (MIRT024276), hsa-mir-148b-3p (MIRT019273), hsa-mir-296-3p (MIRT038395), hsa-mir-193b-3p (MIRT016315), hsa-mir-34a-5p (MIRT047354)

    Block miRNA regulation of human, mouse, rat MCM10 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate MCM10:
    hsa-miR-525-5p hsa-miR-3119 hsa-miR-3674 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidMCM10 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MCM10

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): MCM10 (NM_018518)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCM10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCM10

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MCM10_HUMAN, Q7L590: Nucleus. Note=Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase.
    From early to mid-S phase located in discrete nuclear foci. In early S phase, several hundred foci appeared
    throughout the nucleus. In mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions. In the
    late S and G phases localized to nucleoli
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--

    MCM10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MCM10 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of the pre-replicative complex
    Activation of the pre-replicative complex0.66
    Cell cycle Start of DNA replication in early S phase0.53
    DNA Replication0.66
    2CDK-mediated phosphorylation and removal of Cdc6
    Regulation of DNA replication0.93
    M/G1 Transition0.81
    DNA Replication0.92
    DNA Replication Pre-Initiation0.81
    Removal of licensing factors from origins0.86
    Cell Cycle Checkpoints0.58
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    4G2/M Checkpoints
    G2/M Checkpoints0.84
    Activation of ATR in response to replication stress0.84
    5E2F mediated regulation of DNA replication
    G1/S Transition0.81
    Mitotic G1-G1/S phases0.81

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MCM10
        Cell Cycle Control of Chromosomal Replication

    1 GeneGo (Thomson Reuters) Pathway for MCM10
        Cell cycle Start of DNA replication in early S phase

    2 BioSystems Pathways for MCM10
        Cell cycle
    DNA Replication

    3 Reactome Pathways for MCM10
        Activation of ATR in response to replication stress
    Activation of the pre-replicative complex
    Removal of licensing factors from origins



    MCM10 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MCM10: 
              Hepatotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MCM10

    Selected Interacting proteins for MCM10 (Q7L5901, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MCM6Q145661, 2, 3EBI-374912,EBI-374900 MINT-68480 I2D: score=6 
    CALCOCO2Q131372, 3MINT-67312 I2D: score=5 
    CCDC85BQ158342, 3MINT-67231 I2D: score=5 
    CCND3P302812, 3MINT-50440 I2D: score=5 
    CDC45O754192, 3MINT-50388 I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006260DNA replication TAS--
    GO:0008283cell proliferation IEA--

    MCM10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MCM10



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MCM10 gene (2 alternative transcripts): 
    NM_018518.4  NM_182751.2  

    Unigene Cluster for MCM10:

    Minichromosome maintenance complex component 10
    Hs.198363  [show with all ESTs]
    Unigene Representative Sequence: AL136840
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378714(uc001ima.3 uc001imb.3) ENST00000479669 ENST00000484800
    ENST00000378694(uc001imc.3) ENST00000459751 ENST00000481292 ENST00000485659


    miRNA
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    Block miRNA regulation of human, mouse, rat MCM10 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate MCM10:
    hsa-miR-525-5p hsa-miR-3119 hsa-miR-3674 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidMCM10 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): MCM10 (NM_018518)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCM10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCM10
    Primer
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    OriGene qPCR primer pairs and template standards for MCM10
    OriGene qSTAR qPCR primer pairs in human, mouse for MCM10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MCM10
      QuantiTect SYBR Green Assays in human, mouse, rat MCM10
      QuantiFast Probe-based Assays in human, mouse, rat MCM10

    Additional mRNA sequence: 

    AB042719.1 AF119869.1 AK055695.1 AK292701.1 AL136840.1 BC004876.2 BC009108.1 BC101727.1 
    BC143490.1 

    4 DOTS entries:

    DT.70105299  DT.100749517  DT.91939134  DT.91839306 

    Selected AceView cDNA sequences (see all 72):

    BM781578 CR620605 AB042719 BM833978 BM781561 BU542210 AA583783 AI695143 
    AK055695 CB143720 BG777950 CK000876 BC004876 BM852335 BU618352 AI078425 
    BX099770 BG942019 AI636632 NM_182751 BU542039 NM_018518 BE018388 BU615340 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MCM10    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
    SP1:                                                                                                  -                                   -                     
    SP2:                                                                                                  -                                   -                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for MCM10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MCM10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MCM10 Expression
    About this image

    MCM10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MCM10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.198363
        Pathway & Disease-focused RT2 Profiler PCR Array including MCM10: 
              Hepatotoxicity in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for MCM10
    OriGene qSTAR qPCR primer pairs in human, mouse for MCM10
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    QuantiFast Probe-based Assays in human, mouse, rat MCM10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MCM10 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mcm101 , 5 minichromosome maintenance deficient 10 (S. cerevisiae) less1, 5 79.46(n)1
    77.33(a)1
      2 (3.12 cM)5
    700241  NM_027290.31  NP_081566.21 
     49897145 
    chicken
    (Gallus gallus)
    Aves MCM101 minichromosome maintenance complex component 10 68.6(n)
    67.25(a)
      429525  XM_004937487.1  XP_004937544.1 
    lizard
    (Anolis carolinensis)
    Reptilia MCM106
    minichromosome maintenance complex component 10
    61(a)
    1 ↔ 1
    5(89915374-89944821)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3981962 Mcm10p 73.63(n)    AF314535.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mcm101 minichromosome maintenance complex component 10 56.71(n)
    52.59(a)
      553396  NM_001024813.1  NP_001019984.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mcm101 Sensitized chromosome inheritance modifier 19 46.98(n)
    37.26(a)
      35390  NM_136253.3  NP_610097.2 
    worm
    (Caenorhabditis elegans)
    Secernentea mcm-106
    Protein Y47D3A.28 (Y47D3A.28) mRNA, complete cds
    27(a)
    1 ↔ 1
    III(11317570-11326652) WBGene00012935
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MCM10(YIL150C)4 Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins less   --   9(62728-61013) 854656  NP_012116.1 


    ENSEMBL Gene Tree for MCM10 (if available)
    TreeFam Gene Tree for MCM10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MCM10 (see all 1363)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1506610351,2
    --13201648(+) ACGATA/GGCCAC 2 -- us2k10--------
    rs79085151,2
    C,F,H--13201887(+) CTTTTC/TTCAAA 2 -- us2k1 trp39Minor allele frequency- T:0.26NS EA NA CSA WA 780
    rs1817772401,2
    --13201986(+) TTGCCC/TGGAAC 2 -- us2k10--------
    rs1461929861,2
    C--13201993(+) GAACT-/GGATGC 2 -- us2k10--------
    rs1175013571,2
    C,F--13202053(+) TCAGAA/GTTAGT 2 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1154265311,2
    F--13202062(+) GTCAAG/AGAATT 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs361888201,2
    C--13202104(+) GAATCT/-TTTTT 2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs722759561,2
    C--13202135(+) GATGC-/ATTT  
            
    ATTTA
    2 -- us2k10--------
    rs1385205311,2
    C--13202135(+) GATGC-/ATTTA 
     TTTATTT
    ATTTA
    2 -- us2k10--------
    rs1864309791,2
    C--13202264(+) GCGATC/TCTCCG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MCM10 (13203554 - 13253104 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MCM10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2733317CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MCM10
    DNA2.0 Custom Variant and Variant Library Synthesis for MCM10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609357    OMIM disorders: --

    7 diseases for MCM10:    
    About MalaCards
    rothmund-thomson syndrome    dilated cardiomyopathy    myocardial infarction    neuroblastoma
    diabetes mellitus    alzheimer's disease    malaria

    1 disease from the University of Copenhagen DISEASES database for MCM10:
    Rothmund-Thomson syndrome

    MCM10 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): MCM10
    Human Genome Epidemiology (HuGE) Navigator: MCM10 (5 documents)

    Export disorders for MCM10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MCM10 gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with MCM10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication. (PubMed id 17699597)1, 2, 3, 9 Chattopadhyay S. and Bielinsky A.K. (Mol. Biol. Cell 2007)
    2. The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. (PubMed id 11095689)1, 2, 3, 9 Izumi M.... Hanaoka F. (Nucleic Acids Res. 2000)
    3. Physical interactions between Mcm10, DNA, and DNA polymerase alpha. (PubMed id 19608746)1, 2, 9 Warren E.M.... Eichman B.F. (J. Biol. Chem. 2009)
    4. Cell cycle-dependent proteolysis and phosphorylation of human Mcm10. (PubMed id 11602595)1, 2, 9 Izumi M.... Hanaoka F. (J. Biol. Chem. 2001)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)
    7. Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group. (PubMed id 19795399)1, 4 Malhotra A....Hanson R.L. (Diabetes Metab. Res. Rev. 2009)
    8. MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication. (PubMed id 19696745)1, 2 Xu X.... Liu Y. (EMBO J. 2009)
    9. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008)
    10. Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. (PubMed id 17761813)1, 2 Zhu W.... Dutta A. (Genes Dev. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55388 HGNC: 18043 AceView: MCM10 Ensembl:ENSG00000065328 euGenes: HUgn55388
    ECgene: MCM10 H-InvDB: MCM10

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MCM10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MCM10 gene:
    Search GeneIP for patents involving MCM10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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