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Aliases for MCM10 Gene

Aliases for MCM10 Gene

  • Minichromosome Maintenance Complex Component 10 2 3
  • HsMCM10 3 4
  • CNA43 3 6
  • MCM10 Minichromosome Maintenance Deficient 10 (S. Cerevisiae) 2
  • MCM10 Minichromosome Maintenance Deficient 10 3
  • Homolog Of Yeast MCM10 3
  • Protein MCM10 Homolog 3
  • PRO2249 3
  • DNA43 3

External Ids for MCM10 Gene

Summaries for MCM10 Gene

Entrez Gene Summary for MCM10 Gene

  • The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for MCM10 Gene

MCM10 (Minichromosome Maintenance Complex Component 10) is a Protein Coding gene. Diseases associated with MCM10 include rothmund-thomson syndrome. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for MCM10 Gene

  • Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication.

Gene Wiki entry for MCM10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCM10 Gene

Genomics for MCM10 Gene

Genomic Location for MCM10 Gene

Start:
13,161,554 bp from pter
End:
13,211,104 bp from pter
Size:
49,551 bases
Orientation:
Plus strand

Genomic View for MCM10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCM10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCM10 Gene

Regulatory Elements for MCM10 Gene

Proteins for MCM10 Gene

  • Protein details for MCM10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L590-MCM10_HUMAN
    Recommended name:
    Protein MCM10 homolog
    Protein Accession:
    Q7L590
    Secondary Accessions:
    • A8K9I6
    • B7ZKZ8
    • Q3MIR3
    • Q7LD55
    • Q96GX4
    • Q96NB6
    • Q9H0D7
    • Q9H3P9
    • Q9P177

    Protein attributes for MCM10 Gene

    Size:
    875 amino acids
    Molecular mass:
    98183 Da
    Quaternary structure:
    • Self-associates (By similarity). Interacts with ORC2. May interact with MCM2 and MCM6. Interacts with the DNA polymerase alpha subunit POLA1. Interacts with RECQL4; this interaction regulates RECQL4 unwinding activity. Interacts with WDHD1.
    SequenceCaution:
    • Sequence=AAF69623.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MCM10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCM10 Gene

Proteomics data for MCM10 Gene at MOPED

Post-translational modifications for MCM10 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys313 and Lys627

Other Protein References for MCM10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MCM10 Gene

Domains for MCM10 Gene

Protein Domains for MCM10 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MCM10_HUMAN
Domain:
  • Each zinc finger-like domain binds a zinc ion and is involved in both ssDNA and dsDNA binding, as is the OB-fold domain.:
    • Q7L590
  • The N-terminal domain mediates homodimerization.:
    • Q7L590
Family:
  • Belongs to the MCM10 family.:
    • Q7L590
genes like me logo Genes that share domains with MCM10: view

No data available for Gene Families for MCM10 Gene

Function for MCM10 Gene

Molecular function for MCM10 Gene

UniProtKB/Swiss-Prot Function: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication.

Gene Ontology (GO) - Molecular Function for MCM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 11095689
GO:0042802 identical protein binding IPI 17823614
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MCM10: view
genes like me logo Genes that share phenotypes with MCM10: view

Animal Models for MCM10 Gene

MGI Knock Outs for MCM10:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MCM10 Gene

Localization for MCM10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCM10 Gene

Nucleus. Note=Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase. From early to mid-S phase located in discrete nuclear foci. In early S phase, several hundred foci appeared throughout the nucleus. In mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions. In the late S and G phases localized to nucleoli.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCM10 Gene COMPARTMENTS Subcellular localization image for MCM10 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MCM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MCM10: view

Pathways for MCM10 Gene

genes like me logo Genes that share pathways with MCM10: view

Pathways by source for MCM10 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for MCM10 Gene
1 Qiagen pathway for MCM10 Gene

Gene Ontology (GO) - Biological Process for MCM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006260 DNA replication TAS --
GO:0008283 cell proliferation IEA --
genes like me logo Genes that share ontologies with MCM10: view

Transcripts for MCM10 Gene

Unigene Clusters for MCM10 Gene

Minichromosome maintenance complex component 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MCM10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
SP1: - -
SP2: - -
SP3:
SP4:
SP5:

Relevant External Links for MCM10 Gene

GeneLoc Exon Structure for
MCM10
ECgene alternative splicing isoforms for
MCM10

Expression for MCM10 Gene

mRNA expression in normal human tissues for MCM10 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MCM10 Gene

SOURCE GeneReport for Unigene cluster for MCM10 Gene Hs.198363

genes like me logo Genes that share expressions with MCM10: view

Orthologs for MCM10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MCM10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCM10 36
  • 99.01 (n)
  • 98.97 (a)
MCM10 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MCM10 36
  • 84.96 (n)
  • 82.66 (a)
MCM10 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCM10 36
  • 84.54 (n)
  • 83.62 (a)
MCM10 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcm10 36
  • 79.46 (n)
  • 77.33 (a)
Mcm10 16
Mcm10 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCM10 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCM10 37
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcm10 36
  • 80.2 (n)
  • 79.12 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 65 (a)
OneToMany
-- 37
  • 78 (a)
OneToMany
MCM10 36
  • 68.6 (n)
  • 67.25 (a)
lizard
(Anolis carolinensis)
Reptilia MCM10 37
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398196 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mcm10 36
  • 61.83 (n)
  • 60.29 (a)
Str.1798 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2336 36
zebrafish
(Danio rerio)
Actinopterygii mcm10 36
  • 56.71 (n)
  • 52.59 (a)
mcm10 37
  • 49 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008723 36
  • 44.89 (n)
  • 33.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mcm10 36
  • 46.98 (n)
  • 37.26 (a)
Mcm10 37
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mcm-10 37
  • 27 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCM10 37
  • 20 (a)
OneToOne
MCM10 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 44 (a)
OneToMany
-- 37
  • 40 (a)
OneToMany
Species with no ortholog for MCM10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MCM10 Gene

ENSEMBL:
Gene Tree for MCM10 (if available)
TreeFam:
Gene Tree for MCM10 (if available)

Paralogs for MCM10 Gene

No data available for Paralogs for MCM10 Gene

Variants for MCM10 Gene

Sequence variations from dbSNP and Humsavar for MCM10 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs768255 -- 13,168,175(+) GATGG(C/T)GGAGG intron-variant
rs942412 -- 13,184,829(-) TGCCA(A/C)TTCAC intron-variant
rs1408362 -- 13,206,639(+) CTAAA(A/C)ATGTC intron-variant
rs1535852 -- 13,201,345(+) ATCAT(C/T)GAGTT intron-variant
rs1535856 -- 13,175,940(-) TACTA(C/T)CATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCM10 Gene

Variant ID Type Subtype PubMed ID
esv2733317 CNV Deletion 23290073

Relevant External Links for MCM10 Gene

HapMap Linkage Disequilibrium report
MCM10

Disorders for MCM10 Gene

(1) University of Copenhagen DISEASES for MCM10 Gene

Relevant External Links for MCM10

Genetic Association Database (GAD)
MCM10
Human Genome Epidemiology (HuGE) Navigator
MCM10
genes like me logo Genes that share disorders with MCM10: view

No data available for UniProtKB/Swiss-Prot for MCM10 Gene

Publications for MCM10 Gene

  1. The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. (PMID: 11095689) Izumi M. … Hanaoka F. (Nucleic Acids Res. 2000) 2 3 4 23
  2. Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication. (PMID: 17699597) Chattopadhyay S. … Bielinsky A.K. (Mol. Biol. Cell 2007) 2 3 4 23
  3. Cell cycle-dependent proteolysis and phosphorylation of human Mcm10. (PMID: 11602595) Izumi M. … Hanaoka F. (J. Biol. Chem. 2001) 3 4 23
  4. Physical interactions between Mcm10, DNA, and DNA polymerase alpha. (PMID: 19608746) Warren E.M. … Eichman B.F. (J. Biol. Chem. 2009) 3 4 23
  5. Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. (PMID: 19805216) Im J.S. … Lee J.K. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23

Products for MCM10 Gene

Sources for MCM10 Gene

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