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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MCM10 Gene

protein-coding   GIFtS: 57
GCID: GC10P013116

minichromosome maintenance complex component 10

(Previous name: MCM10 minichromosome maintenance deficient 10 (S. cerevisiae)...)
 Explore 6 diseases affiliated with
MCM10 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MCM10    

Aliases
for MCM10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Minichromosome Maintenance Complex Component 101 2     Homolog Of Yeast MCM102
CNA431 2 5     HsMCM103
DNA431 2     MCM10 Minichromosome Maintenance Deficient 102
PRO22491     Protein MCM10 Homolog2
MCM10 Minichromosome Maintenance Deficient 10 (S. Cerevisiae)1     HsMCM103

External Ids:    HGNC: 180431   Entrez Gene: 553882   Ensembl: ENSG000000653287   OMIM: 6093575   UniProtKB: Q7L5903   

Export aliases for MCM10 gene to outside databases

Previous GC identifers: GC10P013185 GC10P013353 GC10P013207 GC10P013243


Summaries
for MCM10 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MCM10:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are
involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a
key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and
in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as
with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent
manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA
replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding
distinct isoforms have been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MCM10_HUMAN, Q7L590
Function: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase
alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during
replication

Gene Wiki entry for MCM10


Genomic Views
for MCM10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MCM10 gene promoter:
         Max1   SRF   AML1a   SRF (504 AA)   Pax-2   MIF-1   FOXO4   Cart-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MCM10 promoter sequence
   Search SABiosciences Chromatin IP Primers for MCM10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCM10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p13   Ensembl cytogenetic band:  10p13   HGNC cytogenetic band: 10p13

MCM10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCM10 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P013116:  view genomic region     (about GC identifiers)

Start:
 13,203,554 bp from pter      End:
 13,253,104 bp from pter
Size:
 49,551 bases      Orientation:
 plus strand

Proteins
for MCM10 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MCM10_HUMAN, Q7L590 (See protein sequence)
Recommended Name: Protein MCM10 homolog  
Size: 875 amino acids; 98183 Da
Subunit: Self-associates (By similarity). Interacts with ORC2. May interact with MCM2 and MCM6. Interacts with the DNA
polymerase alpha subunit POLA1. Interacts with RECQL4; this interaction regulates RECQL4 unwinding activity. Interacts
with WDHD1
Subcellular location: Nucleus. Note=Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase. From
early to mid-S phase located in discrete nuclear foci. In early S phase, several hundred foci appeared throughout the
nucleus. In mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions. In the late S and G phases
localized to nucleoli
Developmental stage: Expression is cell cycle regulated. Expression increases at the G1/S-boundary. Expression
decreases in late M phase, remains low during G(1) phase, and starts to accumulate at the onset of S phase
Sequence caution: Sequence=AAF69623.1; Type=Erroneous initiation;
Secondary accessions: A8K9I6 B7ZKZ8 Q3MIR3 Q7LD55 Q96GX4 Q96NB6 Q9H0D7 Q9H3P9 Q9P177
Alternative splicing: 2 isoforms:  Q7L590-1   Q7L590-2   

Explore the universe of human proteins at neXtProt for MCM10: NX_Q7L590

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7L590

    • MCM10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_060988.3  NP_877428.1  

    ENSEMBL proteins: 
     ENSP00000367986   ENSP00000418268   ENSP00000417094   ENSP00000367966   ENSP00000354945  
    Reactome Protein details: Q7L590
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 3): MCM10
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    Novus Biologicals MCM10 Protein
    Novus Biologicals MCM10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MCM10

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--


    MCM10 for ontologies           About GeneDecksing



    MCM10 Antibody Products: 
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    Uscn Antibodies for MCM10
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    Uscn ELISAs and CLIAs for MCM10

    Protein Domains /
    Families
    for MCM10 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MCM10 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR015411 Rep_factor_Mcm10
     IPR015408 Znf_Mcm10/DnaG

    Graphical View of Domain Structure for InterPro Entry Q7L590

    ProtoNet protein and cluster: Q7L590

    UniProtKB/Swiss-Prot: MCM10_HUMAN, Q7L590
    Domain: Each zinc finger-like domain binds a zinc ion and is involved in both ssDNA and dsDNA binding, as is the
    OB-fold domain (By similarity)
    Domain: The N-terminal domain mediates homodimerization (By similarity)
    Similarity: Belongs to the MCM10 family


    Function
    for MCM10 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MCM10_HUMAN, Q7L590
    Function: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase
    alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during
    replication

    miRNA
    Products:            		miRTarBase miRNAs that target MCM10:
    hsa-mir-192 (MIRT004854)

    OriGene 3'-UTR Clone (see all 2): MCM10
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCM10
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate MCM10:
    hsa-miR-525-5p hsa-miR-3119 hsa-miR-3674 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MCM10 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCM10 (see all 7)
    OriGene shRNA RFP: MCM10
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MCM10

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCM10 

    Cell Line
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    Search LifeMap BioReagents cell lines for MCM10

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM10

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI16189514
    GO:0046872metal ion binding IEA--


    MCM10 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for MCM10:
     Bright nuclei  Increased S DNA content, incre  Increased cell number in G2M,   Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Mcm10tm1Hlee for MCM10
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mcm10):
     cellular  embryogenesis  mortality/aging 

    MCM10 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MCM10 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitinated Orc1 is degraded by the proteasome
    		Regulation of DNA replication0.68
    		M/G1 Transition0.62
    		Removal of licensing factors from origins0.68
    		DNA Replication0.49
    		DNA Replication Pre-Initiation0.62
    		Cell Cycle Checkpoints0.42
    2Cell cycle_Start of DNA replication in early S phase
    		Cell cycle_Start of DNA replication in early S phase1.00
    		Cell cycle Start of DNA replication in early S phase0.98
    3Activation of ATR in response to replication stress
    		Activation of ATR in response to replication stress1.00
    		G2/M Checkpoints0.86
    4Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84
    5Activation of the pre-replicative complex
    		Activation of the pre-replicative complex1.00
    		DNA Replication0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for MCM10
        Cell cycle Start of DNA replication in early S phase

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MCM10
        Cell Cycle Control of Chromosomal Replication

    1 GeneGo (Thomson Reuters) Pathway for MCM10
        Cell cycle Start of DNA replication in early S phase

    1 BioSystems Pathway for MCM10 
        DNA Replication

    5/14        Reactome Pathways for MCM10 (see all 14)
        Activation of ATR in response to replication stress
    Mitotic G1-G1/S phases
    DNA Replication
    Removal of licensing factors from origins
    Cell Cycle



    MCM10 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MCM10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/84 Interacting proteins for MCM10 (Q7L5901, 2, 3 ENSP000003549454) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-67231 I2D: score=5 STRING: ENSP00000311695
    CCND3P302812, 3, ENSP000003620824MINT-50440 I2D: score=5 STRING: ENSP00000362082
    CEP70Q8NHQ12, 3, ENSP000002649824MINT-66032 I2D: score=5 STRING: ENSP00000264982
    CEP72Q9P2092, 3, ENSP000002649354MINT-67593 I2D: score=5 STRING: ENSP00000264935
    KRT15P190122, 3, ENSP000002540434MINT-66029 I2D: score=5 STRING: ENSP00000254043
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000216M/G1 transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006260DNA replication TAS--


    MCM10 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MCM10 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MCM10
    Search CenterWatch for drugs/clinical trials and news about MCM10 

    Transcripts
    for MCM10 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MCM10 gene (2 alternative transcripts): 
    NM_018518.4  NM_182751.2  

    Unigene Cluster for MCM10:

    Minichromosome maintenance complex component 10
    Hs.198363  [show with all ESTs]
    Unigene Representative Sequence: AL136840
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378714(uc001ima.3 uc001imb.3) ENST00000484800 ENST00000479669
    ENST00000378694(uc001imc.3) ENST00000459751 ENST00000481292 ENST00000485659
    ENST00000361282

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): MCM10
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCM10
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate MCM10:
    hsa-miR-525-5p hsa-miR-3119 hsa-miR-3674 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MCM10 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCM10 (see all 7)
    OriGene shRNA RFP: MCM10
    OriGene siRNA: MCM10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MCM10
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): MCM10 (NM_018518)
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    Primer
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    Additional cDNA sequence: 

    AB042719.1 AF119869.1 AK055695.1 AK292701.1 AL136840.1 BC004876.2 BC009108.1 BC101727.1 
    BC143490.1 

    4 DOTS entries:

    DT.70105299  DT.100749517  DT.91939134  DT.91839306 

    24/72 AceView cDNA sequences (see all 72):

    BG777950 NM_182751 AB042719 AI636632 BU542039 CR620605 AI695143 AA583783 
    NM_018518 BX099770 CB143720 BG942019 AK055695 BM833978 BU542210 BM781578 
    BM781561 BE018388 BU618352 BC004876 AI078425 BM852335 CK000876 BP359743 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MCM10    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
    SP1:                                                                                                  -                                   -                     
    SP2:                                                                                                  -                                   -                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for MCM10

    Expression
    for MCM10 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MCM10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MCM10 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MCM10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MCM10

    SOURCE GeneReport for Unigene cluster: Hs.198363
        SABiosciences Expression via Pathway-Focused PCR Array including MCM10: 
              Hepatotoxicity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCM10

    Orthologs
    for MCM10 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MCM10 gene from 9/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mcm101 , 5 minichromosome maintenance deficient 10 (S. cerevisiae)1, 5 79.77(n)1
    77.67(a)1    		   2 (3.12 cM)5
    700241  NM_027290.31  NP_081566.21 
     49897145 
    chicken
    (Gallus gallus)    		 Aves MCM101 minichromosome maintenance complex component 10 68.14(n)
    66.47(a)    		   429525  XM_427082.3  XP_427082.3 
    lizard
    (Anolis carolinensis)    		 Reptilia MCM106
    		 --
    		 60(a)
    		 1 ↔ 1
    		 5(89917645-89943781)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3981962 Mcm10p 73.63(n)    AF314535.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mcm101 minichromosome maintenance complex component 10 56.55(n)
    52.09(a)    		   553396  NM_001024813.1  NP_001019984.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Mcm101 Sensitized chromosome inheritance modifier 19 45.08(n)
    34.71(a)    		   35390  NM_136253.3  NP_610097.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y47D3A.281 Protein Y47D3A.28 41.38(n)
    26.97(a)    		   176562  NM_067055.2  NP_499456.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MCM106
    		 minichromosome maintenance protein 10
    		 22(a)
    		 1 ↔ 1
    		 2(9011389-9013931)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 MCM10 - Putative minichromosome maintenance MCM pr...
    		 20(a)
    		 1 ↔ 1
    		 9(21239269-21242101)


    ENSEMBL Gene Tree for MCM10 (if available)
    TreeFam Gene Tree for MCM10 (if available) 

    Paralogs
    for MCM10 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for MCM10 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1138 NCBI SNPs in MCM10 are shown (see all 1138)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1506610351,2
    		--13201648(+) ACGATA/GGCCAC 2 -- us2k10--------
    rs79085151,2
    		C,F,H,--13201887(+) CTTTTC/TTCAAA 2 -- us2k1 trp39Minor allele frequency- T:0.26NS EA NA CSA WA 780
    rs1817772401,2
    		--13201986(+) TTGCCC/TGGAAC 2 -- us2k10--------
    rs1461929861,2
    		C,--13201993(+) GAACT-/GGATGC 2 -- us2k10--------
    rs1175013571,2
    		C,F,--13202053(+) TCAGAA/GTNNNN 2 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1154265311,2
    		F,--13202062(+) GTCAAG/AGAATT 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs361888201,2
    		C,--13202104(+) GAATCT/-TTTTT 2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs722759561,2
    		C--13202135(+) GATGC-/ATTT  
                ATTTA     		2 -- us2k10--------
    rs1385205311,2
    		C,--13202135(+) GATGC-/ATTTA 
     TTTATTT    ATTTA     		2 -- us2k10--------
    rs1864309791,2
    		--13202264(+) GCGATC/TCTCCG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MCM10 (13203554 - 13253104 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MCM10: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MCM10
    DNA2.0 Custom Variant and Variant Library Synthesis for MCM10

    Disorders / Diseases
    for MCM10 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MCM10 for disorders           About GeneDecksing

    OMIM gene information: 609357    OMIM disorders: --

    6 diseases for MCM10:    About MalaCards
    rothmund-thomson syndrome    dilated cardiomyopathy    cardiomyopathy    alzheimer's disease
    nephropathy    neuroblastoma

    1 disease from the University of Copenhagen DISEASES database for MCM10:
    Rothmund-Thomson syndrome
    Human Genome Epidemiology (HuGE) Navigator: MCM10 (5 documents)

    Export disorders for MCM10 gene to outside databases

    Publications
    for MCM10 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MCM10 gene, integrated from 9 sources (see all 54):
    (articles sorted by number of sources associating them with MCM10)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication. (PubMed id 17699597)1, 2, 3, 9 Chattopadhyay S. and Bielinsky A.K. (2007)
    2. The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. (PubMed id 11095689)1, 2, 3, 9 Izumi M.... Hanaoka F. (2000)
    3. Physical interactions between Mcm10, DNA, and DNA polymerase alpha. (PubMed id 19608746)1, 2, 9 Warren E.M.... Eichman B.F. (2009)
    4. Cell cycle-dependent proteolysis and phosphorylation of human Mcm10. (PubMed id 11602595)1, 2, 9 Izumi M.... Hanaoka F. (2001)
    5. MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication. (PubMed id 19696745)1, 2 Xu X.... Liu Y. (2009)
    6. Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. (PubMed id 17761813)1, 2 Zhu W....Dutta A. (2007)
    7. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
    8. Localization of human Mcm10 is spatially and temporally regulated during the S phase. (PubMed id 15136575)1, 2 Izumi M.... Hanaoka F. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for MCM10 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MCM10 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55388 HGNC: 18043 AceView: MCM10 Ensembl:ENSG00000065328 euGenes: HUgn55388
    ECgene: MCM10 H-InvDB: MCM10

    Other Databases showing MCM10 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MCM10 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MCM10 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MCM10 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MCM10 gene:
    Search GeneIP for patents involving MCM10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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