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Aliases for MCM10 Gene

Aliases for MCM10 Gene

  • Minichromosome Maintenance 10 Replication Initiation Factor 2 3 5
  • Minichromosome Maintenance Complex Component 10 2 3
  • HsMCM10 3 4
  • MCM10 Minichromosome Maintenance Deficient 10 (S. Cerevisiae) 2
  • MCM10 Minichromosome Maintenance Deficient 10 3
  • Homolog Of Yeast MCM10 3
  • PRO2249 3
  • CNA43 3
  • DNA43 3

External Ids for MCM10 Gene

Previous GeneCards Identifiers for MCM10 Gene

  • GC10P013185
  • GC10P013353
  • GC10P013207
  • GC10P013243
  • GC10P013116
  • GC10P013203

Summaries for MCM10 Gene

Entrez Gene Summary for MCM10 Gene

  • The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for MCM10 Gene

MCM10 (Minichromosome Maintenance 10 Replication Initiation Factor) is a Protein Coding gene. Among its related pathways are Cell Cycle Control of Chromosomal Replication and E2F mediated regulation of DNA replication. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for MCM10 Gene

  • Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359).

Gene Wiki entry for MCM10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCM10 Gene

Genomics for MCM10 Gene

Regulatory Elements for MCM10 Gene

Enhancers for MCM10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MCM10 on UCSC Golden Path with GeneCards custom track

Genomic Location for MCM10 Gene

Chromosome:
10
Start:
13,161,554 bp from pter
End:
13,211,104 bp from pter
Size:
49,551 bases
Orientation:
Plus strand

Genomic View for MCM10 Gene

Genes around MCM10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCM10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCM10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCM10 Gene

Proteins for MCM10 Gene

  • Protein details for MCM10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L590-MCM10_HUMAN
    Recommended name:
    Protein MCM10 homolog
    Protein Accession:
    Q7L590
    Secondary Accessions:
    • A8K9I6
    • B7ZKZ8
    • Q3MIR3
    • Q7LD55
    • Q96GX4
    • Q96NB6
    • Q9H0D7
    • Q9H3P9
    • Q9P177

    Protein attributes for MCM10 Gene

    Size:
    875 amino acids
    Molecular mass:
    98183 Da
    Quaternary structure:
    • Self-associates (By similarity). Interacts with ORC2. May interact with MCM2 and MCM6. Interacts with the DNA polymerase alpha subunit POLA1. Interacts with RECQL4; this interaction regulates RECQL4 unwinding activity. Interacts with WDHD1.
    SequenceCaution:
    • Sequence=AAF69623.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MCM10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCM10 Gene

Proteomics data for MCM10 Gene at MOPED

Post-translational modifications for MCM10 Gene

  • Ubiquitination at Lys 313 and Lys 627
  • Modification sites at PhosphoSitePlus

Other Protein References for MCM10 Gene

Antibody Products

No data available for DME Specific Peptides for MCM10 Gene

Domains & Families for MCM10 Gene

Protein Domains for MCM10 Gene

Suggested Antigen Peptide Sequences for MCM10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L590

UniProtKB/Swiss-Prot:

MCM10_HUMAN :
  • Each zinc finger-like domain binds a zinc ion and is involved in both ssDNA and dsDNA binding, as is the OB-fold domain.
  • Belongs to the MCM10 family.
Domain:
  • Each zinc finger-like domain binds a zinc ion and is involved in both ssDNA and dsDNA binding, as is the OB-fold domain.
  • The N-terminal domain mediates homodimerization.
Family:
  • Belongs to the MCM10 family.
genes like me logo Genes that share domains with MCM10: view

No data available for Gene Families for MCM10 Gene

Function for MCM10 Gene

Molecular function for MCM10 Gene

UniProtKB/Swiss-Prot Function:
Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359).

Gene Ontology (GO) - Molecular Function for MCM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IBA --
GO:0042802 identical protein binding IPI 17823614
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MCM10: view
genes like me logo Genes that share phenotypes with MCM10: view

Animal Models for MCM10 Gene

MGI Knock Outs for MCM10:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MCM10 Gene

Localization for MCM10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCM10 Gene

Nucleus. Note=Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase. From early to mid-S phase located in discrete nuclear foci. In early S phase, several hundred foci appeared throughout the nucleus. In mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions. In the late S and G phases localized to nucleoli.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCM10 Gene COMPARTMENTS Subcellular localization image for MCM10 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MCM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0031298 replication fork protection complex IBA --
genes like me logo Genes that share ontologies with MCM10: view

Pathways & Interactions for MCM10 Gene

genes like me logo Genes that share pathways with MCM10: view

Pathways by source for MCM10 Gene

SIGNOR curated interactions for MCM10 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for MCM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA,TAS --
GO:0006270 DNA replication initiation IBA --
GO:0008283 cell proliferation IEA --
genes like me logo Genes that share ontologies with MCM10: view

Drugs & Compounds for MCM10 Gene

No Compound Related Data Available

Transcripts for MCM10 Gene

Unigene Clusters for MCM10 Gene

Minichromosome maintenance complex component 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MCM10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
SP1: - -
SP2: - -
SP3:
SP4:
SP5:

Relevant External Links for MCM10 Gene

GeneLoc Exon Structure for
MCM10
ECgene alternative splicing isoforms for
MCM10

Expression for MCM10 Gene

mRNA expression in normal human tissues for MCM10 Gene

Protein differential expression in normal tissues from HIPED for MCM10 Gene

This gene is overexpressed in Cerebrospinal fluid (28.6), Kidney (13.8), Lung (10.5), Urine (6.7), and Placenta (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MCM10 Gene



SOURCE GeneReport for Unigene cluster for MCM10 Gene Hs.198363

genes like me logo Genes that share expression patterns with MCM10: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MCM10 Gene

Orthologs for MCM10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MCM10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MCM10 35
  • 84.96 (n)
  • 82.66 (a)
MCM10 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCM10 35
  • 84.54 (n)
  • 83.62 (a)
MCM10 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcm10 35
  • 79.46 (n)
  • 77.33 (a)
Mcm10 16
Mcm10 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MCM10 35
  • 99.01 (n)
  • 98.97 (a)
MCM10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcm10 35
  • 80.2 (n)
  • 79.12 (a)
oppossum
(Monodelphis domestica)
Mammalia MCM10 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCM10 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves MCM10 35
  • 68.6 (n)
  • 67.25 (a)
-- 36
  • 65 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MCM10 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mcm10 35
  • 61.83 (n)
  • 60.29 (a)
Str.1798 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398196 35
zebrafish
(Danio rerio)
Actinopterygii mcm10 35
  • 56.71 (n)
  • 52.59 (a)
mcm10 36
  • 49 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2336 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008723 35
  • 44.89 (n)
  • 33.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mcm10 35
  • 46.98 (n)
  • 37.26 (a)
Mcm10 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mcm-10 36
  • 27 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCM10 36
  • 20 (a)
OneToOne
MCM10 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
Species with no ortholog for MCM10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MCM10 Gene

ENSEMBL:
Gene Tree for MCM10 (if available)
TreeFam:
Gene Tree for MCM10 (if available)

Paralogs for MCM10 Gene

No data available for Paralogs for MCM10 Gene

Variants for MCM10 Gene

Sequence variations from dbSNP and Humsavar for MCM10 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs17152897 - 13,172,427(+) GCTAA(A/G)AGTAA reference, missense
rs7905784 - 13,192,356(+) AAGCC(A/T)CAGCT reference, missense
rs2274110 - 13,197,651(+) GGCAA(A/G)AGGCC reference, missense
rs34630110 - 13,172,753(-) TGAAG(C/G)CTTTG reference, missense
rs35114749 - 13,188,915(-) ACTGA(A/G)CCTGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MCM10 Gene

Variant ID Type Subtype PubMed ID
esv2733317 CNV Deletion 23290073

Variation tolerance for MCM10 Gene

Residual Variation Intolerance Score: 96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.76; 83.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCM10 Gene

HapMap Linkage Disequilibrium report
MCM10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCM10 Gene

Disorders for MCM10 Gene

Relevant External Links for MCM10

Genetic Association Database (GAD)
MCM10
Human Genome Epidemiology (HuGE) Navigator
MCM10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCM10

No disorders were found for MCM10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MCM10 Gene

Publications for MCM10 Gene

  1. Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication. (PMID: 17699597) Chattopadhyay S. … Bielinsky A.K. (Mol. Biol. Cell 2007) 2 3 4 23 67
  2. The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. (PMID: 11095689) Izumi M. … Hanaoka F. (Nucleic Acids Res. 2000) 2 3 23
  3. Ultraviolet radiation stress triggers the down-regulation of essential replication factor Mcm10. (PMID: 20064936) Sharma A. … Saxena S. (J. Biol. Chem. 2010) 3 23
  4. Physical interactions between Mcm10, DNA, and DNA polymerase alpha. (PMID: 19608746) Warren E.M. … Eichman B.F. (J. Biol. Chem. 2009) 3 23
  5. Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. (PMID: 19805216) Im J.S. … Lee J.K. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23

Products for MCM10 Gene

Sources for MCM10 Gene

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