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MCL1 Gene

protein-coding   GIFtS: 68
GCID: GC01M150547

Myeloid Cell Leukemia 1

(Previous name: myeloid cell leukemia sequence 1 (BCL2-related))
  See MCL1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myeloid Cell Leukemia 11 2     MCL1L2
Myeloid Cell Leukemia Sequence 1 (BCL2-Related)1 2     MCL1S2
Bcl-2-Like Protein 32 3     Mcl-12
Bcl-2-Related Protein EAT/Mcl12 3     TM2
BCL2L32 3     bcl2-L-32
mcl1/EAT2 3     Induced Myeloid Leukemia Cell Differentiation Protein Mcl-12
EAT2     Myeloid Cell Leukemia ES2
MCL1-ES2     Bcl2-L-33

External Ids:    HGNC: 69431   Entrez Gene: 41702   Ensembl: ENSG000001433847   OMIM: 1595525   UniProtKB: Q078203   

Export aliases for MCL1 gene to outside databases

Previous GC identifers: GC01M148388 GC01M146294 GC01M147322 GC01M147763 GC01M147360 GC01M148813 GC01M121925


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MCL1 Gene:
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results
in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting
apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and
are death-inducing. (provided by RefSeq, Oct 2010)

GeneCards Summary for MCL1 Gene:
MCL1 (myeloid cell leukemia 1) is a protein-coding gene. Diseases associated with MCL1 include cholangiocarcinoma, and megalencephalic leukoencephalopathy with subcortical cysts. GO annotations related to this gene include protein channel activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot: MCL1_HUMAN, Q07820
Function: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but
not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.
Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis

Gene Wiki entry for MCL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the MCL1 gene promoter:
         AP-1   ATF-2   c-Jun   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MCL1 promoter sequence
   Search Chromatin IP Primers for MCL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MCL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

MCL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M150547:  view genomic region     (about GC identifiers)

Start:
150,547,027 bp from pter      End:
150,552,214 bp from pter
Size:
5,188 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MCL1_HUMAN, Q07820 (See protein sequence)
Recommended Name: Induced myeloid leukemia cell differentiation protein Mcl-1  
Size: 350 amino acids; 37337 Da
Subunit: Interacts with BAD, BOK, BIK and BFM. Interacts with PMAIP1. Isoform 1 interacts with BAX, BAK1, TPT1 and
BCL2L11. Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2
does not interact with pro-apoptotic BCL2-related proteins. Interacts with BOP. Interacts with BCL2L11; may
sequester BCL2L11 to prevent its pro-apoptotic activity
Selected PDB 3D structures from and Proteopedia for MCL1 (see all 18):
2KBW (3D)        2NL9 (3D)        2NLA (3D)        2PQK (3D)        3D7V (3D)        3IO9 (3D)    
Secondary accessions: B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1
Alternative splicing: 2 isoforms:  Q07820-1   Q07820-2   

Explore the universe of human proteins at neXtProt for MCL1: NX_Q07820

Explore proteomics data for MCL1 at MOPED

Post-translational modifications: 

  • Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a
    pro-apoptotic 28 kDa C-terminal fragment1
  • Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region1
  • Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159
    induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol
    or okadaic acid induces phosphorylation on additional sites1
  • Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-1591
  • Ubiquitination2 at Lys5, Lys40, Lys136, Lys194, Lys197, Lys308
  • Modification sites at PhosphoSitePlus

  • See MCL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001184249.1  NP_068779.1  NP_877495.1  

    ENSEMBL proteins: 
     ENSP00000358022   ENSP00000309973  

    MCL1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MCL1 (Mcl-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MCL1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MCL1
    GenScript Custom Purified and Recombinant Proteins Services for MCL1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MCL1
    Cloud-Clone Corp. Proteins for MCL1

     
    Search eBioscience for Proteins for MCL1 

     
    antibodies-online proteins for MCL1 (3 products) 

     
    antibodies-online peptides for MCL1

    MCL1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MCL1
    R&D Systems Antibodies for MCL1 (Mcl-1)
    Cell Signaling Technology (CST) Antibodies for MCL1 
    OriGene Antibodies for MCL1
    OriGene Custom Antibody Services for MCL1
    Novus Biologicals MCL1 Antibodies
    Abcam antibodies for MCL1
    Cloud-Clone Corp. Antibodies for MCL1
    ThermoFisher Antibody for MCL1
    antibodies-online antibodies for MCL1 (218 products) 

    MCL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MCL1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MCL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MCL1
    Cloud-Clone Corp. CLIAs for MCL1
    Search eBioscience for ELISAs for MCL1 
    antibodies-online kits for MCL1 (11 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR020728 Bcl2_BH3_motif_CS
     IPR013281 Apop_reg_Mc1
     IPR020717 Bcl2_BH1_motif_CS
     IPR020726 Bcl2_BH2_motif_CS
     IPR002475 Bcl2-like

    Graphical View of Domain Structure for InterPro Entry Q07820

    ProtoNet protein and cluster: Q07820

    1 Blocks protein domain: IPB000712 Apoptosis regulator Bcl-2 protein

    UniProtKB/Swiss-Prot: MCL1_HUMAN, Q07820
    Similarity: Belongs to the Bcl-2 family


    Find genes that share domains with MCL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MCL1_HUMAN, Q07820
    Function: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but
    not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.
    Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis
    Induction: Expression increases early during phorbol ester-induced differentiation along the monocyte/macrophage
    pathway in myeloid leukemia cell line ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat
    shock-induced differentiation. Expression increases early during retinoic acid-induced differentiation

         Genatlas biochemistry entry for MCL1:
    myeloid cell leukemia 1,involved in programmed myeloid cell differentiation,with homology to BCL2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15901672
    GO:0015266protein channel activity TAS10837489
    GO:0042803protein homodimerization activity IBA--
    GO:0046982protein heterodimerization activity IPI10837489
    GO:0051434BH3 domain binding IPI--
         
    Find genes that share ontologies with MCL1           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for MCL1:
     Decreased cell number  Decreased viability after Chla  G0/1 arrest  Increased gamma-H2AX phosphory 
     Increased number of mitotic ce  Synthetic lethal with cisplati 

         8 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Mcl1):
     cellular  embryogenesis  hematopoietic system  immune system  integument 
     mortality/aging  normal  reproductive system 

    Find genes that share phenotypes with MCL1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MCL1: Mcl1tm1Yen Mcl1tm1Sjk

       genOway: Develop your customized and physiologically relevant rodent model for MCL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MCL1:
    hsa-mir-29c-3p (MIRT003288), hsa-mir-3679-3p (MIRT052877), hsa-mir-133a-3p (MIRT052648), hsa-mir-661 (MIRT004743), hsa-mir-15a-5p (MIRT000878), hsa-mir-30d-5p (MIRT047799), hsa-mir-320a (MIRT004440), hsa-mir-886-3p (MIRT006591), hsa-mir-16-5p (MIRT000877), hsa-mir-26b-5p (MIRT030090), hsa-mir-186-5p (MIRT021163), hsa-mir-193b-3p (MIRT004663), hsa-mir-181a-5p (MIRT006949), hsa-mir-512-5p (MIRT004406), hsa-mir-26a-5p (MIRT052649), hsa-mir-615-3p (MIRT040421), hsa-mir-153-3p (MIRT004080), hsa-mir-582-5p (MIRT004668), hsa-mir-876-3p (MIRT004744), hsa-mir-29b-3p (MIRT003287), hsa-mir-29a-3p (MIRT003286), hsa-mir-181b-5p (MIRT006952), hsa-mir-892b (MIRT004745), hsa-mir-193a-3p (MIRT002485), hsa-mir-101-3p (MIRT003921), hsa-mir-133b (MIRT003260), hsa-mir-151a-3p (MIRT019504), hsa-mir-148b-5p (MIRT004746), hsa-mir-518a-5p (MIRT004667)

    Block miRNA regulation of human, mouse, rat MCL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MCL1 (see all 86):
    hsa-miR-520e hsa-miR-607 hsa-miR-3607-3p hsa-miR-520f hsa-miR-193a-3p hsa-miR-106a hsa-miR-93 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidMCL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MCL1
    Predesigned siRNA for gene silencing in human, mouse, rat MCL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MCL1

    Clone
    Products:
         
    OriGene clones in human, mouse for MCL1 (see all 17)
    OriGene ORF clones in mouse, rat for MCL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MCL1 (NM_021960)
    Sino Biological Human cDNA Clone for MCL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCL1
    Addgene plasmids for MCL1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MCL1
    Browse ESI BIO Cell Lines and PureStem Progenitors for MCL1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCL1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12649) for MCL1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MCL1_HUMAN, Q07820: Membrane; Single-pass membrane protein (Potential). Cytoplasm. Mitochondrion. Nucleus,
    nucleoplasm. Note=Cytoplasmic, associated with mitochondria
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol3
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IEA--
    GO:0005737cytoplasm TAS10837489
    GO:0005739mitochondrion IDA--
    GO:0005741mitochondrial outer membrane TAS10837489

    Find genes that share ontologies with MCL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MCL1 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis (WikiPathways)
    Apoptosis0.38
    Apoptosis Modulation and Signaling0.38
    2IL-9 Signaling Pathways
    IL-7 Signaling Pathway0.40
    3Immune response Antigen presentation by MHC class II
    Immune response IL 22 signaling pathway0.31
    4PI3K-Akt signaling pathway
    PI3K-Akt signaling pathway
    5MicroRNAs in cancer
    MicroRNAs in cancer


    Find genes that share SuperPaths with MCL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for MCL1
        IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types


    1 Cell Signaling Technology (CST) Pathway for MCL1
        Apoptosis and Autophagy

    2 GeneGo (Thomson Reuters) Pathways for MCL1
        Immune response IL-22 signaling pathway
    Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

    Selected BioSystems Pathways for MCL1 (see all 7)
        Apoptosis
    Apoptosis Modulation and Signaling
    IL-7 Signaling Pathway
    E2F transcription factor network
    IL6-mediated signaling events



    2 Kegg Pathways  (Kegg details for MCL1):
        PI3K-Akt signaling pathway
    MicroRNAs in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MCL1 (see all 12): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Leukemia in human mouse rat
              Lymphoma in human mouse rat
              Liver Cancer in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MCL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MCL1 (Q078201, 2, 3 ENSP000003580224) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAXQ078121, 2, 3, ENSP000002932884EBI-1003422,EBI-516580 MINT-7307171 MINT-7306728 MINT-4980279 MINT-4980319 I2D: score=5 STRING: ENSP00000293288
    BCL2L11O435211, 2, 3EBI-1003422,EBI-526406 MINT-68751 MINT-4980348 MINT-4980279 MINT-4980319 MINT-7543162 I2D: score=12 
    BAK1Q166111, 2, 3, ENSP000003635914EBI-1003422,EBI-519866 MINT-7306728 MINT-7306752 I2D: score=5 STRING: ENSP00000363591
    PMAIP1Q137941, 2, 3, ENSP000003261194EBI-1003422,EBI-707392 MINT-7543162 I2D: score=4 STRING: ENSP00000326119
    HUWE1Q7Z6Z72, 3, ENSP000002628544MINT-68753 MINT-68750 MINT-68749 MINT-68752 I2D: score=5 STRING: ENSP00000262854
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001709cell fate determination NAS10837489
    GO:0007275multicellular organismal development IEA--
    GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage IBA--
    GO:0008637apoptotic mitochondrial changes IEA--
    GO:0019725cellular homeostasis NAS10837489

    Find genes that share ontologies with MCL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for MCL1 (see all 19)     About this table
    CompoundAction CAS #
    2,3-DCPE hydrochlorideSelectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro[418788-90-6]
    ABT-199Selective Bcl-2 inhibitor[1257044-40-8]
    ABT-263 (Navitoclax)orally sellecitive inhibitor of Bcl-2 family proteins[923564-51-6]
    ABT-737novel and potent inhibitor of BCL-2 family proteins[852808-04-9]
    Apogossypolone (ApoG2)pan Bcl-2 inhibitor[886578-07-0]
    AT-101R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1[90141-22-3]
    Bax channel blockerPotent inhibitor of Bax-mediated mitochondrial cytochrome c release[335165-68-9]
    Bax inhibitor peptide P5Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria[579492-83-4]
    Bax inhibitor peptide V5Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria[579492-81-2]
    Bax inhibitor peptide, negative controlNegative control peptide for the Bax inhibitor peptides V5 and P5[1315378-74-5]

    Browse Tocris compounds for MCL1

    Selected Novoseek inferred chemical compound relationships for MCL1 gene (see all 87)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    noxa 88.2 82 19372561 (7), 17018621 (4), 20051518 (4), 16782027 (3) (see all 34)
    flavopiridol 77.6 34 12429644 (4), 12517783 (3), 18000861 (2), 16432172 (2) (see all 17)
    roscovitine 68.5 20 15827128 (4), 17234790 (4), 17942397 (1), 19228744 (1) (see all 8)
    pd-184352 68 4 20117835 (2), 17218385 (1), 19773546 (1)
    bortezomib 67.1 24 20051518 (4), 17545623 (3), 18566236 (3), 17018621 (3) (see all 7)
    sorafenib 62.3 39 17909059 (5), 17634558 (4), 17595328 (4), 20071162 (4) (see all 19)
    fludarabine 59.5 18 16501812 (3), 18599795 (2), 15370246 (2), 17018621 (2) (see all 9)
    ly294002 58.7 18 12606824 (2), 11585835 (2), 11314001 (1), 12479056 (1) (see all 12)
    imatinib 56.7 14 18088462 (2), 17595328 (2), 15626746 (2), 12727828 (1) (see all 8)
    gossypol 55.8 14 18762177 (6)



    Find genes that share compounds with MCL1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MCL1 gene (3 alternative transcripts): 
    NM_001197320.1  NM_021960.4  NM_182763.2  

    Unigene Cluster for MCL1:

    Myeloid cell leukemia sequence 1 (BCL2-related)
    Hs.632486  [show with all ESTs]
    Unigene Representative Sequence: NM_021960
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369026(uc010pch.2 uc021oyf.1 uc001euz.3 uc001eva.3)
    ENST00000464132 ENST00000307940
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MCL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MCL1 (see all 86):
    hsa-miR-520e hsa-miR-607 hsa-miR-3607-3p hsa-miR-520f hsa-miR-193a-3p hsa-miR-106a hsa-miR-93 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidMCL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MCL1
    Predesigned siRNA for gene silencing in human, mouse, rat MCL1
    Clone
    Products:
         
    OriGene clones in human, mouse for MCL1 (see all 17)
    OriGene ORF clones in mouse, rat for MCL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MCL1 (NM_021960)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCL1
    Addgene plasmids for MCL1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MCL1
    OriGene qSTAR qPCR primer pairs in human, mouse for MCL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MCL1
      QuantiTect SYBR Green Assays in human, mouse, rat MCL1
      QuantiFast Probe-based Assays in human, mouse, rat MCL1
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12649) for MCL1 

    Additional mRNA sequence: 

    AF118124.1 AF118276.1 AF118277.1 AF118278.1 AF203373.1 AK294462.1 AK297217.1 AK300499.1 
    AK304775.1 AK312508.1 AK316267.1 BC017197.2 BC071897.1 BC107735.1 BT006640.1 FJ917536.1 
    L08246.1 

    Selected DOTS entries (see all 27):

    DT.95301973  DT.449911  DT.95301975  DT.92454096  DT.100883419  DT.92454081  DT.121443994  DT.121443999 
    DT.95301970  DT.95210901  DT.92025156  DT.95301989  DT.95301980  DT.121444038  DT.101964311  DT.121443995 
    DT.121444001  DT.121444002  DT.121444016  DT.121444037  DT.95301954  DT.95301956  DT.99943281  DT.100883430 

    Selected AceView cDNA sequences (see all 849):

    AA282815 AI249665 BM725225 BQ716214 CR618814 BM692689 BX438900 AI624921 
    BM976410 CA420573 AA040674 BM974028 BF436437 AI287364 AI521664 AW628807 
    BI912368 BX384319 AA903078 AA040576 BP356106 AA521334 AI953772 AW170180 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MCL1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b
    SP1:                    -                           
    SP2:                    -     -                     
    SP3:                    -     -     -               
    SP4:                                                


    ECgene alternative splicing isoforms for MCL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MCL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACATTCTGT
    MCL1 Expression
    About this image


    MCL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    MCL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MCL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632486
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MCL1 (see all 12): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Leukemia in human mouse rat
              Lymphoma in human mouse rat
              Liver Cancer in human mouse rat
              Apoptosis in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for MCL1
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    QuantiFast Probe-based Assays in human, mouse, rat MCL1
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for MCL1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mcl11 , 5 myeloid cell leukemia sequence 11, 5 81.17(n)1
    80.66(a)1
      3 (40.74 cM)5
    172101  NM_008562.31  NP_032588.11 
     956587215 
    chicken
    (Gallus gallus)
    Aves MCL11 myeloid cell leukemia sequence 1 (BCL2-related) 64.98(n)
    62.16(a)
      395674  NM_001257283.1  NP_001244212.1 
    lizard
    (Anolis carolinensis)
    Reptilia MCL16
    myeloid cell leukemia sequence 1 (BCL2-related)
    45(a)
    1 ↔ 1
    GL343779.1(45963-137682)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ028977.12   -- 69.78(n)    BJ028977.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mcl1a1 myeloid cell leukemia sequence 1a 51.38(n)
    44.04(a)
      58122  NM_131599.1  NP_571674.1 


    ENSEMBL Gene Tree for MCL1 (if available)
    TreeFam Gene Tree for MCL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MCL1 gene

    Find genes that share paralogs with MCL1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MCL1
    PGOHUM00000245769


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MCL1 (see all 218)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs346544581,2
    C--150546790(+) TTTGATTT/-TTTTA 3 -- cds11Minor allele frequency- -:0.00NA 2
    rs356094811,2
    C--150547483(-) ATGACTG/-TGGAA 3 -- ut315Minor allele frequency- -:0.00NS 186
    rs30651111,2
    C--150548887(-) CTTAG-/ATA   
      G
    /TAGA
    GTTTT
    6 -- ut316NS CSA 188
    rs1139127011,2
    C--150548887(+) AAAAAC/TCTAAG 3 -- ut310--------
    rs1452437281,2
    C--150548888(+) AAACC-/CTAT  
            
    TAAGG
    3 -- ut310--------
    rs580907821,2
    C--150548890(+) ACCTATCTA/-  
            
    AGGAA
    3 -- ut311Minor allele frequency- -:0.00NA 2
    rs31158731,2
    C--150552281(-) CCGGCC/TCAGGC 3 -- us2k10--------
    rs38319871,2
    C--150552290(+) GGGCC-/GGGGCCTG
    AGCCGGGGCC
    TGAGC
    6 -- us2k1 cds11Minor allele frequency- GGGGCCTGAGCCGGGGCC:0.00NA 2
    rs1885562051,2
    --157048000(+) GGTGGA/CGCATG 3 -- ds50010--------
    rs121262711,2
    C,F--157048001(+) GTGGCA/GCATGC 3 -- ds50014Minor allele frequency- G:0.38NA WA 8

    HapMap Linkage Disequilibrium report for MCL1 (150547027 - 150552214 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MCL1: --
    Human Gene Mutation Database (HGMD): MCL1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MCL1
    DNA2.0 Custom Variant and Variant Library Synthesis for MCL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 159552    OMIM disorders: --

    5 diseases for MCL1:    
    About MalaCards
    cholangiocarcinoma    megalencephalic leukoencephalopathy with subcortical cysts    anaplastic large cell lymphoma    myeloma
    myeloid leukemia


    Find genes that share disorders with MCL1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MCL1 gene (see all 76)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphocytic leukemia chronic b-cell 72.3 8 19487028 (2), 14695629 (2), 19581935 (1), 15291360 (1) (see all 6)
    leukemia lymphocytic chronic 70.4 12 15126604 (2), 19008456 (2), 12210808 (1), 18599795 (1) (see all 10)
    leukemia 62 50 17909059 (2), 9446661 (2), 17178043 (2), 16109713 (2) (see all 34)
    myeloma 59.5 40 15459900 (4), 10583232 (4), 15902294 (3), 10602002 (3) (see all 21)
    cancer 57.9 52 16761109 (2), 18399351 (2), 17495324 (2), 19099185 (2) (see all 38)
    tumors 57.7 114 8909234 (4), 9060818 (4), 16361547 (3), 17561513 (3) (see all 70)
    leukemia b-cell 54 2 19581935 (1), 19092849 (1), 15728130 (1)
    myeloid leukemia 51.1 9 16761109 (3), 16806223 (1), 7682708 (1), 12788061 (1) (see all 7)
    lymphoma 49.3 23 11389033 (2), 8080035 (1), 15854132 (1), 16487175 (1) (see all 18)
    leukaemia lymphocytic 49.2 2 15759030 (1), 16501812 (1)

    Genetic Association Database (GAD): MCL1
    Human Genome Epidemiology (HuGE) Navigator: MCL1 (7 documents)

    Export disorders for MCL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for MCL1 gene, integrated from 10 sources (see all 905):
    (articles sorted by number of sources associating them with MCL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. (PubMed id 7682708)1, 2, 3, 9 Kozopas K.M.... Craig R.W. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    2. MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. (PubMed id 10837489)1, 2, 9 Bae J.... Hsueh A.J.W. (J. Biol. Chem. 2000)
    3. Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and fortilin. The potential role of MCL1 as a fortilin chaperone. (PubMed id 12149273)1, 2, 9 Zhang D.... Fujise K. (J. Biol. Chem. 2002)
    4. Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage. (PubMed id 15122313)1, 2, 9 Michels J....Packham G. (Oncogene 2004)
    5. Exon skipping in Mcl-1 results in a Bcl-2 homology domain 3 only gene product that promotes cell death. (PubMed id 10766760)1, 2, 9 Bingle C.D....Whyte M.K.B. (J. Biol. Chem. 2000)
    6. Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. (PubMed id 15989957)1, 2, 9 Zhong Q.... Wang X. (Cell 2005)
    7. Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. (PubMed id 15077116)1, 2, 9 Leu J.I.-J.... George D.L. (Nat. Cell Biol. 2004)
    8. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. (PubMed id 16543145)1, 2, 9 Maurer U....Green D.R. (Mol. Cell 2006)
    9. MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol. (PubMed id 15241487)1, 2, 9 Domina A.M.... Craig R.W. (Oncogene 2004)
    10. Mcl-1 is an immediate-early gene activated by the granulocyte- macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response. (PubMed id 9671497)1, 2, 9 Chao J.-R....Yang-Yen H.-F. (Mol. Cell. Biol. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4170 HGNC: 6943 AceView: MCL1 Ensembl:ENSG00000143384 euGenes: HUgn4170
    ECgene: MCL1 Kegg: 4170 H-InvDB: MCL1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MCL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MCL1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mcl1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MCL1 gene:
    Search GeneIP for patents involving MCL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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