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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MCL1 Gene

protein-coding GIFtS: 64
GCID: GC01M150547

myeloid cell leukemia sequence 1 (BCL2-related)

Explore 99 diseases affiliated with
MCL1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Myeloid Cell Leukemia Sequence 1 (BCL2-Related)¹ ²		MCL1L²
BCL2L3¹ ² ³		MCL1S²
Mcl-1¹ ²		TM²
Bcl-2-Like Protein 3² ³		Bcl2-L-3³
Bcl-2-Related Protein EAT/Mcl1² ³		Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1²
Mcl1/EAT¹		Myeloid Cell Leukemia ES²
EAT²		Bcl2-L-3³
MCL1-ES²

External Ids:	HGNC: 6943¹	Entrez Gene: 4170²	Ensembl: ENSG00000143384⁷	OMIM: 159552⁵	UniProtKB: Q07820³

Export aliases for MCL1 gene to outside databases

Previous GC identifers: GC01M148388 GC01M146294 GC01M147322 GC01M147763 GC01M147360 GC01M148813 GC01M121925

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MCL1:

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in

multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis

while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are

death-inducing. (provided by RefSeq, Oct 2010)

UniProtKB/Swiss-Prot: MCL1_HUMAN, Q07820

Function: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of

proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits

apoptosis. Isoform 2 promotes apoptosis

Gene Wiki entry for MCL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MCL1 gene promoter:
AP-1 ATF-2 c-Jun STAT5A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MCL1 promoter sequence

Search SABiosciences Chromatin IP Primers for MCL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21

MCL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCL1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M150547: view genomic region (about GC identifiers)

Start:	150,547,032 bp from pter	End:	150,552,136 bp from pter
Size:	5,105 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MCL1_HUMAN, Q07820 (See protein sequence)

Recommended Name: Induced myeloid leukemia cell differentiation protein Mcl-1

Size: 350 amino acids; 37337 Da

Subunit: Interacts with BAD, BOK, BIK and BFM (By similarity). Interacts with PMAIP1. Isoform 1 interacts with BAX,

BAK1, TPT1 and BCL2L11. Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected.

Isoform 2 does not interact with pro-apoptotic BCL2-related proteins. Interacts with BOP (By similarity)

Subcellular location: Membrane; Single-pass membrane protein (Potential). Cytoplasm. Mitochondrion. Nucleus,

nucleoplasm. Note=Cytoplasmic, associated with mitochondria

6/16 PDB 3D structures from and Proteopedia for MCL1 (see all 16):

2KBW (3D)

2NL9 (3D)

2NLA (3D)

2PQK (3D)

3D7V (3D)

3IO9 (3D)

Secondary accessions: B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1

Alternative splicing: 2 isoforms: Q07820-1 Q07820-2

Explore the universe of human proteins at neXtProt for MCL1: NX_Q07820

Post-translational modifications:

Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a

pro-apoptotic 28 kDa C-terminal fragment¹

Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region¹

Phosphorylated on Thr-163. Treatment with taxol or okadaic acid induces phosphorylation on additional sites¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q07820

MCL1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001184249.1 NP_068779.1 NP_877495.1

ENSEMBL proteins:

ENSP00000358022 ENSP00000309973

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for MCL1 (Mcl-1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: MCL1 OriGene Custom Protein Services for MCL1
	GenScript Custom Purified and Recombinant Proteins Services for MCL1
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for MCL1
	Uscn Proteins for MCL1

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	IEA	--
GO:0005737	cytoplasm	TAS	10837489
GO:0005739	mitochondrion	IDA	--
GO:0005741	mitochondrial outer membrane	TAS	10837489

MCL1 for ontologies About GeneDecksing

MCL1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MCL1
	R&D Systems Antibodies for MCL1 (Mcl-1)
	Cell Signaling Technology (CST) Antibodies for MCL1
	OriGene Antibodies (see all 15): MCL1 OriGene Custom Antibody Services for MCL1
	GenScript Superior Antibodies for MCL1
	Abcam antibodies for MCL1
	Uscn Antibodies for MCL1
	ThermoFisher Antibody for MCL1

Assay Products for MCL1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MCL1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MCL1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MCL1 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR020728 Bcl2_BH3_motif_CS

IPR013281 Apop_reg_Mc1

IPR020717 Bcl2_BH1_motif_CS

IPR020726 Bcl2_BH2_motif_CS

IPR002475 Bcl2-like

Graphical View of Domain Structure for InterPro Entry Q07820

ProtoNet protein and cluster: Q07820

1 Blocks protein family: IPB000712 Apoptosis regulator Bcl-2 protein

UniProtKB/Swiss-Prot: MCL1_HUMAN, Q07820

Similarity: Belongs to the Bcl-2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MCL1_HUMAN, Q07820

Function: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of

proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits

apoptosis. Isoform 2 promotes apoptosis

Induction: Expression increases early during phorbol ester-induced differentiation along the monocyte/macrophage

pathway in myeloid leukemia cell line ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat

shock-induced differentiation. Expression increases early during retinoic acid-induced differentiation

Genatlas biochemistry entry for MCL1:

myeloid cell leukemia 1,involved in programmed myeloid cell differentiation,with homology to BCL2

miRNA Products:		miRTarBase miRNAs that target MCL1: hsa-mir-512-5p (MIRT004406), hsa-mir-29c (MIRT003288), hsa-mir-876-3p (MIRT004744), hsa-mir-582-5p (MIRT004668), hsa-mir-153 (MIRT004080), hsa-mir-661 (MIRT004743), hsa-mir-29b (MIRT003287), hsa-mir-29a (MIRT003286), hsa-mir-320a (MIRT004440), hsa-mir-892b (MIRT004745), hsa-mir-193a-3p (MIRT002485), hsa-mir-133b (MIRT003260), hsa-mir-101 (MIRT003921), hsa-mir-193b (MIRT004663), hsa-mir-148b (MIRT004746), hsa-mir-518a-5p (MIRT004667)

		OriGene 3'-UTR Clone (see all 2): MCL1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCL1
		8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate MCL1 (see all 86):
		hsa-miR-520e hsa-miR-607 hsa-miR-3607-3p hsa-miR-520f hsa-miR-193a-3p hsa-miR-106a hsa-miR-93 hsa-miR-3148

		SwitchGear 3'UTR luciferase reporter plasmid: MCL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCL1 (see all 7) OriGene shRNA RFP: MCL1 OriGene siRNA: MCL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MCL1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MCL1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCL1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCL1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): MCL1 (NM_021960)
		Sino Biological Human cDNA Clone for MCL1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCL1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MCL1
		Search LifeMap BioReagents cell lines for MCL1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCL1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0015266	protein channel activity	TAS	10837489
GO:0046982	protein heterodimerization activity	IPI	10837489
GO:0051434	BH3 domain binding	IPI	--

MCL1 for ontologies About GeneDecksing

6 GenomeRNAi human phenotypes for MCL1:

Decreased cell number	Decreased viability after Chla	G0/1 arrest	Increased gamma-H2AX phosphory
Increased number of mitotic ce	Synthetic lethal with cisplati

Animal Models:
Mouse knock-outs for MCL1: Mcl1^tm1Yen Mcl1^tm1Sjk
8 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Mcl1):

cellular	embryogenesis	hematopoietic system	immune system	integument
mortality/aging	normal	reproductive system

MCL1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptosis Modulation and Signaling

Apoptosis Modulation and Signaling

1.00

Apoptosis

0.38

Immune response IL-22 signaling pathway

Immune response IL-22 signaling pathway

1.00

Immune response_IL-22 signaling pathway

0.87

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

0.24

Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins

0.24

Apoptosis and Autophagy

Apoptosis and Autophagy

1.00

HIF-1-alpha transcription factor network

HIF-1-alpha transcription factor network

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for MCL1

	Immune response IL-22 signaling pathway
	Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

1 R&D Systems Pathway for MCL1

IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types

1 Cell Signaling Technology (CST) Pathway for MCL1

Apoptosis and Autophagy

2 GeneGo (Thomson Reuters) Pathways for MCL1

	Immune response IL-22 signaling pathway
	Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

5/7 BioSystems Pathways for MCL1 (see all 7)

	Apoptosis Modulation and Signaling
	Apoptosis
	IL-7 Signaling Pathway
	HIF-1-alpha transcription factor network
	Direct p53 effectors

MCL1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MCL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/70 Interacting proteins for MCL1 (Q07820^{1, 2, 3} ENSP00000358022⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 70)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BAX	Q07812¹^,²^,³, ENSP00000293288⁴	EBI-1003422,EBI-516580 MINT-7307171 MINT-7306728 MINT-4980279 MINT-4980319 I2D: score=5 STRING: ENSP00000293288
BCL2L11	O43521¹^,²^,³	EBI-1003422,EBI-1002160 MINT-68751 MINT-4980348 MINT-4980279 MINT-4980319 MINT-7543162 I2D: score=12
BAK1	Q16611¹^,²^,³, ENSP00000363591⁴	EBI-1003422,EBI-519866 MINT-7306728 MINT-7306752 I2D: score=5 STRING: ENSP00000363591
PMAIP1	Q13794¹^,²^,³, ENSP00000326119⁴	EBI-1003422,EBI-707392 MINT-7543162 I2D: score=4 STRING: ENSP00000326119
HUWE1	Q7Z6Z7²^,³, ENSP00000262854⁴	MINT-68753 MINT-68750 MINT-68749 MINT-68752 I2D: score=5 STRING: ENSP00000262854

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001709	cell fate determination	NAS	10837489
GO:0006915	apoptotic process	IDA	10837489
GO:0007275	multicellular organismal development	IEA	--
GO:0019725	cellular homeostasis	NAS	10837489
GO:0034097	response to cytokine stimulus	IDA	9184696

MCL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MCL1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MCL1
10/87 Novoseek chemical compound relationships for MCL1 gene (see all 87) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
noxa	88.2	82	19372561 (7), 17018621 (4), 20051518 (4), 16782027 (3) (see all 34)
flavopiridol	77.6	34	12429644 (4), 12517783 (3), 18000861 (2), 16432172 (2) (see all 17)
roscovitine	68.5	20	15827128 (4), 17234790 (4), 17942397 (1), 19228744 (1) (see all 8)
pd-184352	68	4	20117835 (2), 17218385 (1), 19773546 (1)
bortezomib	67.1	24	20051518 (4), 17545623 (3), 18566236 (3), 17018621 (3) (see all 7)
sorafenib	62.3	39	17909059 (5), 17634558 (4), 17595328 (4), 20071162 (4) (see all 19)
fludarabine	59.5	18	16501812 (3), 18599795 (2), 15370246 (2), 17018621 (2) (see all 9)
ly294002	58.7	18	12606824 (2), 11585835 (2), 11314001 (1), 12479056 (1) (see all 12)
imatinib	56.7	14	18088462 (2), 17595328 (2), 15626746 (2), 12727828 (1) (see all 8)
gossypol	55.8	14	18762177 (6)

Search CenterWatch for drugs/clinical trials and news about MCL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MCL1 gene (3 alternative transcripts):

NM_001197320.1 NM_021960.4 NM_182763.2

Unigene Cluster for MCL1:

Myeloid cell leukemia sequence 1 (BCL2-related)

Hs.632486 [show with all ESTs]

Unigene Representative Sequence: NM_021960

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000369026(uc010pch.2 uc021oyf.1 uc001euz.3 uc001eva.3)

ENST00000464132 ENST00000307940

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MCL1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCL1
		8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate MCL1 (see all 86):
		hsa-miR-520e hsa-miR-607 hsa-miR-3607-3p hsa-miR-520f hsa-miR-193a-3p hsa-miR-106a hsa-miR-93 hsa-miR-3148

		SwitchGear 3'UTR luciferase reporter plasmid: MCL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCL1 (see all 7) OriGene shRNA RFP: MCL1 OriGene siRNA: MCL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MCL1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCL1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCL1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): MCL1 (NM_021960)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCL1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MCL1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MCL1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCL1

Additional cDNA sequence:

AF118124.1 AF118276.1 AF118277.1 AF118278.1 AF203373.1 AK294462.1 AK297217.1 AK300499.1

AK304775.1 AK312508.1 AK316267.1 BC017197.2 BC071897.1 BC107735.1 BT006640.1 FJ917536.1

L08246.1

24/27 DOTS entries (see all 27):

DT.95301973 DT.449911 DT.95301975 DT.92454096 DT.100883419 DT.92454081 DT.121443994 DT.121443999

DT.95301970 DT.95210901 DT.92025156 DT.95301989 DT.95301980 DT.121444038 DT.101964311 DT.121443995

DT.121444001 DT.121444002 DT.121444016 DT.121444037 DT.95301954 DT.95301956 DT.99943281 DT.100883430

24/849 AceView cDNA sequences (see all 849):

AV716418 BE891878 BP356106 CA420573 BQ946108 CA306295 AI200499 AI357125

BM976410 BU541505 AI347351 NM_021960 AI953772 AV654800 BP341402 AA564590

AI242412 BU727383 AI676215 BU624922 AW189547 AV685436 AV658665 AI367170

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for MCL1 About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3a	·	3b
SP1:							-
SP2:							-		-
SP3:							-		-		-
SP4:

ECgene alternative splicing isoforms for MCL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MCL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACATTCTGT

About this image
See MCL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MCL1

SOURCE GeneReport for Unigene cluster: Hs.632486

SABiosciences Expression via Pathway-Focused PCR Arrays including MCL1 (see all 12):

Oncogenes & Tumor Suppressor Genes in human mouse rat

Leukemia in human mouse rat

Lymphoma in human mouse rat

Liver Cancer in human mouse rat

Apoptosis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MCL1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MCL1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCL1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MCL1 gene from 5/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mcl1^{1 , 5}	myeloid cell leukemia sequence 1^{1, 5}	81.17(n)¹ 80.66(a)¹		3 (40.74 cM)⁵ 17210¹ NM_008562.3¹ NP_032588.1¹ 95658721⁵
chicken (Gallus gallus)	Aves	MCL1¹	myeloid cell leukemia sequence 1 (BCL2-related)	61.04(n) 56.69(a)		395674 XM_001233734.2 XP_001233735.2
lizard (Anolis carolinensis)	Reptilia	MCL1⁶	--	52(a)	1 ↔ 1	GL343779.1(131347-137095)
African clawed frog (Xenopus laevis)	Amphibia	BJ028977.1²	--	69.78(n)		BJ028977.1
zebrafish (Danio rerio)	Actinopterygii	mcl1a¹	myeloid cell leukemia sequence 1a	51.22(n) 44.04(a)		58122 NM_131599.1 NP_571674.1

ENSEMBL Gene Tree for MCL1 (if available)
TreeFam Gene Tree for MCL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MCL1 gene

MCL1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for MCL1
PGOHUM00000245769

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188556205^1,2		--	150546597(+)	`GGTGGA/CGCATG`	3	--	ds500¹		0	--	--	--	--
rs12126271^1,2	C,F,	--	150546598(+)	`GTGGCA/GCATGC`	3	--	ds500¹		4		NA WA	8
rs181637718^1,2		--	150546616(+)	`CCCAGA/CTACTC`	3	--	ds500¹		0	--	--	--	--
rs141957591^1,2	C,	--	150546790(+)	`TTTGA-/TTTTTTTA`	3	--	ds500¹		0	--	--	--	--
rs34654458^1,2	C	--	150546791(+)	`TTGATTTT/-TTTAC`	3	--	ds500¹		1		NA	2
rs185215157^1,2		--	150546856(+)	`CAACAA/CCTCTA`	3	--	ds500¹		0	--	--	--	--
rs6587756^1,2	C,F,H,	--	150546865(+)	`TAATTT/AGAATT`	3	--	ds500¹		17		NS EA NA WA CSA	931
rs36123358^1,2	C,	--	150547096(-)	`GTCAAA/GTGTAG`	3	--	ut3¹		5		NS	190
rs78625781^1,2	C,F,	--	150547218(+)	`TAGAGG/CACTGC`	3	--	ut3¹		1		WA	118
rs11850^1,2		--	150547247(-)	`TGTCTT/CACGCT`	3	--	ut3¹		1		MN	184

HapMap Linkage Disequilibrium report for MCL1 (150547032 - 150552136 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MCL1: --
Human Gene Mutation Database (HGMD): MCL1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MCL1

DNA2.0 Custom Variant and Variant Library Synthesis for MCL1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MCL1 for disorders           About GeneDecksing

OMIM gene information: 159552    OMIM disorders: --

20/99 diseases for MCL1 (see all 99):    About MalaCards

myeloid leukemia leukemia megalencephalic leukoencephalopathy with subcortical cysts spinal cord injury

b-cell non-hodgkin lymphoma t-cell leukemia anaplastic large cell lymphoma non-hodgkin lymphoma

central nervous system lymphoma large granular lymphocyte leukemia lymphocytic leukemia gastrointestinal stromal tumor

primary biliary cirrhosis malignant mesothelioma hodgkin's lymphoma burkitt's lymphoma

b-cell lymphomas leukemia/lymphoma cutaneous malignant melanoma myocardial infarction

10/76 Novoseek disease relationships for MCL1 gene (see all 76) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphocytic leukemia chronic b-cell	72.3	8	19487028 (2), 14695629 (2), 19581935 (1), 15291360 (1) (see all 6)
leukemia lymphocytic chronic	70.4	12	15126604 (2), 19008456 (2), 12210808 (1), 18599795 (1) (see all 10)
leukemia	62	50	17909059 (2), 9446661 (2), 17178043 (2), 16109713 (2) (see all 34)
myeloma	59.5	40	15459900 (4), 10583232 (4), 15902294 (3), 10602002 (3) (see all 21)
cancer	57.9	52	16761109 (2), 18399351 (2), 17495324 (2), 19099185 (2) (see all 38)
tumors	57.7	114	8909234 (4), 9060818 (4), 16361547 (3), 17561513 (3) (see all 70)
leukemia b-cell	54	2	19581935 (1), 19092849 (1), 15728130 (1)
myeloid leukemia	51.1	9	16761109 (3), 16806223 (1), 7682708 (1), 12788061 (1) (see all 7)
lymphoma	49.3	23	11389033 (2), 8080035 (1), 15854132 (1), 16487175 (1) (see all 18)
leukaemia lymphocytic	49.2	2	15759030 (1), 16501812 (1)

Human Genome Epidemiology (HuGE) Navigator: MCL1 (7 documents)

Export disorders for MCL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MCL1 gene, integrated from 9 sources (see all 856):
(articles sorted by number of sources associating them with MCL1)

Utopia: connect your pdf to the dynamic
world of online information

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. (PubMed id 7682708)^{1, 2, 3, 9} Kozopas K.M.... Craig R.W. (1993)
MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. (PubMed id 10837489)^{1, 2, 9} Bae J.... Hsueh A.J.W. (2000)
Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and fortilin. The potential role of MCL1 as a fortilin chaperone. (PubMed id 12149273)^{1, 2, 9} Zhang D.... Fujise K. (2002)
Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage. (PubMed id 15122313)^{1, 2, 9} Michels J....Packham G. (2004)
Exon skipping in Mcl-1 results in a Bcl-2 homology domain 3 only gene product that promotes cell death. (PubMed id 10766760)^{1, 2, 9} Bingle C.D....Whyte M.K.B. (2000)
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. (PubMed id 15989957)^{1, 2, 9} Zhong Q.... Wang X. (2005)
Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. (PubMed id 15077116)^{1, 2, 9} Leu J.I.-J.... George D.L. (2004)
MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol. (PubMed id 15241487)^{1, 2, 9} Domina A.M.... Craig R.W. (2004)
Mcl-1 is an immediate-early gene activated by the granulocyte- macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response. (PubMed id 9671497)^{1, 2, 9} Chao J.-R....Yang-Yen H.-F. (1998)
Human and mouse chromosomal mapping of the myeloid cell leukemia-1 gene: MCL1 maps to human chromosome 1q21, a region that is frequently altered in preneoplastic and neoplastic disease. (PubMed id 7835896)^{1, 3, 9} Craig R.W....Griffin C.A. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4170	HGNC: 6943	AceView: MCL1	Ensembl:ENSG00000143384	euGenes: HUgn4170
ECgene: MCL1	H-InvDB: MCL1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MCL1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MCL1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mcl1/

Intellectual Property for MCL1 gene
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Patent Information for MCL1 gene:
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GeneCards and IP:
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myeloid cell leukemia sequence 1 (BCL2-related)

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MCL1 Gene

myeloid cell leukemia sequence 1 (BCL2-related)

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