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Aliases for MCL1 Gene

Aliases for MCL1 Gene

  • MCL1, BCL2 Family Apoptosis Regulator 2 3
  • Myeloid Cell Leukemia Sequence 1 (BCL2-Related) 2 3
  • BCL2 Family Apoptosis Regulator 3 5
  • Bcl-2-Related Protein EAT/Mcl1 3 4
  • Myeloid Cell Leukemia 1 2 3
  • Bcl-2-Like Protein 3 3 4
  • Bcl2-L-3 3 4
  • Mcl1/EAT 3 4
  • BCL2L3 3 4
  • Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 3
  • Myeloid Cell Leukemia ES 3
  • MCL1-ES 3
  • MCL1L 3
  • MCL1S 3
  • Mcl-1 3
  • EAT 3
  • TM 3

External Ids for MCL1 Gene

Previous GeneCards Identifiers for MCL1 Gene

  • GC01M148388
  • GC01M146294
  • GC01M147322
  • GC01M147763
  • GC01M147360
  • GC01M148813
  • GC01M150547
  • GC01M121925
  • GC01M150581

Summaries for MCL1 Gene

Entrez Gene Summary for MCL1 Gene

  • This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]

GeneCards Summary for MCL1 Gene

MCL1 (MCL1, BCL2 Family Apoptosis Regulator) is a Protein Coding gene. Diseases associated with MCL1 include Myeloid Leukemia and Leukemia. Among its related pathways are Apoptosis and Autophagy and Innate Immune System. GO annotations related to this gene include protein homodimerization activity and BH3 domain binding.

UniProtKB/Swiss-Prot for MCL1 Gene

  • Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

Gene Wiki entry for MCL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCL1 Gene

Genomics for MCL1 Gene

Regulatory Elements for MCL1 Gene

Enhancers for MCL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G150609 2.1 FANTOM5 Ensembl ENCODE dbSUPER 33.7 -33.0 -33005 7.5 PKNOX1 FOXA2 ARID4B SIN3A YY1 SLC30A9 ZNF766 ZNF143 FOS KLF13 HORMAD1 MCL1 CTSS ARNT GOLPH3L VPS72 CDC42SE1 LYSMD1 GABPB2 VPS45
GH01G150618 2 FANTOM5 Ensembl ENCODE dbSUPER 15.3 -43.0 -42981 7.5 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A FEZF1 ZNF766 ZNF207 HORMAD1 MCL1 GOLPH3L ARNT CTSS C1orf54 PRPF3 PLEKHO1 CDC42SE1 MINDY1
GH01G150602 2.1 FANTOM5 Ensembl ENCODE dbSUPER 13 -25.2 -25172 4.1 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 MEF2D GLIS1 RCOR2 PRPF3 HORMAD1 SETDB1 UBE2D3P3 SF3B4 GOLPH3L MCL1 GABPB2 RPS10P6 CTSS
GH01G150626 1.7 FANTOM5 ENCODE dbSUPER 15 -49.6 -49634 4.9 HDGF PKNOX1 FOXA2 ARNT WRNIP1 SIN3A ARID4B DMAP1 YBX1 ZNF2 HORMAD1 SETDB1 GOLPH3L UBE2D3P3 PRPF3 MCL1 SF3B4 ADAMTSL4 RPS10P6 GABPB2
GH01G150320 1.6 FANTOM5 ENCODE 15.1 +258.0 257983 2.4 MLX CREB3L1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC PRPF3 ADAMTSL4 GABPB2 MRPS21 MCL1 LYSMD1 CTSS SEMA6C TARS2 HORMAD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MCL1 on UCSC Golden Path with GeneCards custom track

Promoters for MCL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000013522 1738 4401 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21

Genomic Location for MCL1 Gene

Chromosome:
1
Start:
150,574,551 bp from pter
End:
150,579,738 bp from pter
Size:
5,188 bases
Orientation:
Minus strand

Genomic View for MCL1 Gene

Genes around MCL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCL1 Gene

Proteins for MCL1 Gene

  • Protein details for MCL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07820-MCL1_HUMAN
    Recommended name:
    Induced myeloid leukemia cell differentiation protein Mcl-1
    Protein Accession:
    Q07820
    Secondary Accessions:
    • B2R6B2
    • D3DV03
    • D3DV04
    • Q9HD91
    • Q9NRQ3
    • Q9NRQ4
    • Q9UHR7
    • Q9UHR8
    • Q9UHR9
    • Q9UNJ1

    Protein attributes for MCL1 Gene

    Size:
    350 amino acids
    Molecular mass:
    37337 Da
    Quaternary structure:
    • Interacts with HIF3A (via C-terminus domain) (By similarity). Interacts with BAD, BOK, BIK and BMF (By similarity). Interacts with PMAIP1 (PubMed:17389404). Interacts with BBC3 (By similarity). Isoform 1 interacts with BAX, BAK1 and TPT1 (PubMed:10837489, PubMed:12149273, PubMed:15077116). Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro-apoptotic BCL2-related proteins (PubMed:10837489). Interacts with BOP (PubMed:23055042). Interacts with BCL2L11; may sequester BCL2L11 to prevent its pro-apoptotic activity (PubMed:10837489, PubMed:27013495, PubMed:17389404, PubMed:20562877).

    Three dimensional structures from OCA and Proteopedia for MCL1 Gene

    Alternative splice isoforms for MCL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCL1 Gene

Post-translational modifications for MCL1 Gene

  • Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.
  • Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.
  • Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region.
  • Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-159.
  • Ubiquitination at Lys5, posLast=4040, Lys136, Lys194, posLast=197197, and Lys308
  • Modification sites at PhosphoSitePlus

Other Protein References for MCL1 Gene

No data available for DME Specific Peptides for MCL1 Gene

Domains & Families for MCL1 Gene

Gene Families for MCL1 Gene

Suggested Antigen Peptide Sequences for MCL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q07820

UniProtKB/Swiss-Prot:

MCL1_HUMAN :
  • Belongs to the Bcl-2 family.
Family:
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with MCL1: view

Function for MCL1 Gene

Molecular function for MCL1 Gene

GENATLAS Biochemistry:
myeloid cell leukemia 1,involved in programmed myeloid cell differentiation,with homology to BCL2
UniProtKB/Swiss-Prot Function:
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
UniProtKB/Swiss-Prot Induction:
Expression increases early during phorbol ester-induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell line ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat shock-induced differentiation. Expression increases early during retinoic acid-induced differentiation.

Gene Ontology (GO) - Molecular Function for MCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15901672
GO:0015266 protein channel activity TAS 10837489
GO:0046982 protein heterodimerization activity IPI 10837489
GO:0051434 BH3 domain binding IPI 21036904
genes like me logo Genes that share ontologies with MCL1: view
genes like me logo Genes that share phenotypes with MCL1: view

Animal Models for MCL1 Gene

MGI Knock Outs for MCL1:

Animal Model Products

miRNA for MCL1 Gene

miRTarBase miRNAs that target MCL1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MCL1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MCL1 Gene

Localization for MCL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCL1 Gene

Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCL1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5
plasma membrane 2
cytoskeleton 2
endoplasmic reticulum 2
extracellular 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20467439
GO:0005654 nucleoplasm IEA --
GO:0005737 cytoplasm TAS 10837489
GO:0005739 mitochondrion IDA 7896880
GO:0005741 mitochondrial outer membrane TAS 10837489
genes like me logo Genes that share ontologies with MCL1: view

Pathways & Interactions for MCL1 Gene

genes like me logo Genes that share pathways with MCL1: view

SIGNOR curated interactions for MCL1 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001709 cell fate determination NAS 10837489
GO:0006915 apoptotic process IEA --
GO:0007275 multicellular organism development IEA --
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA --
GO:0008637 apoptotic mitochondrial changes IEA --
genes like me logo Genes that share ontologies with MCL1: view

Drugs & Compounds for MCL1 Gene

(59) Drugs for MCL1 Gene - From: ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mitomycin Approved Pharma Inhibits DNA synthesis,antibiotic and antitumor agent 0
A-1210477 Pharma MCL-1 inhibitor 0
Marinopyrrole A Pharma Selective Mcl-1 inhibitor 0
MIM1 Pharma Mcl-1 Inhibitor, Mcl-1 inhibitor; proapoptotic 0
TW-37 Pharma Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1 0

(35) Additional Compounds for MCL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(6) ApexBio Compounds for MCL1 Gene

Compound Action Cas Number
A-1210477 MCL-1 inhibitor 1668553-26-1
Marinopyrrole A Selective Mcl-1 inhibitor 1227962-62-0
MIM1 Mcl-1 Inhibitor
Mitomycin C Inhibits DNA synthesis,antibiotic and antitumor agent 1950-07-7
TW-37 Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1 877877-35-5
UMI-77 518303-20-3
genes like me logo Genes that share compounds with MCL1: view

Drug Products

Transcripts for MCL1 Gene

Unigene Clusters for MCL1 Gene

Myeloid cell leukemia sequence 1 (BCL2-related):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MCL1

Alternative Splicing Database (ASD) splice patterns (SP) for MCL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for MCL1 Gene

GeneLoc Exon Structure for
MCL1
ECgene alternative splicing isoforms for
MCL1

Expression for MCL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MCL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MCL1 Gene

This gene is overexpressed in Whole Blood (x6.1).

Protein differential expression in normal tissues from HIPED for MCL1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.6), Lymph node (13.2), Heart (6.6), and Liver (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MCL1 Gene



NURSA nuclear receptor signaling pathways regulating expression of MCL1 Gene:

MCL1

SOURCE GeneReport for Unigene cluster for MCL1 Gene:

Hs.632486

Evidence on tissue expression from TISSUES for MCL1 Gene

  • Nervous system(4.9)
  • Blood(4.5)
  • Lung(4.1)
  • Bone marrow(3.6)
  • Liver(3.5)
  • Intestine(3.4)
  • Pancreas(3)
  • Kidney(2.9)
  • Lymph node(2.9)
  • Heart(2.8)
  • Bone(2.6)
  • Muscle(2.6)
  • Skin(2.6)
  • Spleen(2.6)
  • Stomach(2.6)
  • Eye(2.4)
  • Gall bladder(2.4)
  • Adrenal gland(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with MCL1: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCL1 Gene

Orthologs for MCL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MCL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCL1 34 35
  • 99.14 (n)
cow
(Bos Taurus)
Mammalia MCL1 34 35
  • 88.35 (n)
-- 35
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MCL1 34 35
  • 88.19 (n)
rat
(Rattus norvegicus)
Mammalia Mcl1 34
  • 82.12 (n)
mouse
(Mus musculus)
Mammalia Mcl1 34 16 35
  • 81.17 (n)
oppossum
(Monodelphis domestica)
Mammalia MCL1 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves MCL1 34 35
  • 64.98 (n)
lizard
(Anolis carolinensis)
Reptilia MCL1 35
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mcl1a 34 35
  • 51.38 (n)
mcl1b 35
  • 35 (a)
OneToMany
bcl2l10 35
  • 31 (a)
OneToMany
Species where no ortholog for MCL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MCL1 Gene

ENSEMBL:
Gene Tree for MCL1 (if available)
TreeFam:
Gene Tree for MCL1 (if available)

Paralogs for MCL1 Gene

Pseudogenes.org Pseudogenes for MCL1 Gene

genes like me logo Genes that share paralogs with MCL1: view

No data available for Paralogs for MCL1 Gene

Variants for MCL1 Gene

Sequence variations from dbSNP and Humsavar for MCL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000303125 -- 150,578,578(+) AAATC(A/G)CTACT intron-variant, upstream-variant-2KB
rs1000824081 -- 150,574,082(+) AACCC(A/C)ATCTC intron-variant, downstream-variant-500B
rs1001151771 -- 150,574,253(+) ATCTC(-/A)AAAAA nc-transcript-variant, downstream-variant-500B
rs1001346754 -- 150,576,143(+) TTTTT(-/ATATGCACACAGCTA)ATGAG upstream-variant-2KB, utr-variant-3-prime
rs1001856748 -- 150,578,164(+) ACCTT(C/T)AGATA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MCL1 Gene

Variant ID Type Subtype PubMed ID
nsv1006838 CNV gain 25217958

Variation tolerance for MCL1 Gene

Residual Variation Intolerance Score: 50.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCL1 Gene

Human Gene Mutation Database (HGMD)
MCL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCL1 Gene

Disorders for MCL1 Gene

MalaCards: The human disease database

(30) MalaCards diseases for MCL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myeloid leukemia
  • leukemia myelogenous
leukemia
chlamydia
  • chlamydia trachomatis infectious disease
follicular lymphoma
  • lymphoma, follicular
alk-positive anaplastic large cell lymphoma
  • alk+ alcl
- elite association - COSMIC cancer census association via MalaCards
Search MCL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MCL1

Genetic Association Database (GAD)
MCL1
Human Genome Epidemiology (HuGE) Navigator
MCL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCL1
genes like me logo Genes that share disorders with MCL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MCL1 Gene

Publications for MCL1 Gene

  1. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. (PMID: 7682708) Kozopas K.M. … Craig R.W. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 22 64
  2. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. (PMID: 16543145) Maurer U. … Green D.R. (Mol. Cell 2006) 3 4 22 64
  3. MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol. (PMID: 15241487) Domina A.M. … Craig R.W. (Oncogene 2004) 3 4 22 64
  4. Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage. (PMID: 15122313) Michels J. … Packham G. (Oncogene 2004) 3 4 22 64
  5. Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and fortilin. The potential role of MCL1 as a fortilin chaperone. (PMID: 12149273) Zhang D. … Fujise K. (J. Biol. Chem. 2002) 3 4 22 64

Products for MCL1 Gene

  • Addgene plasmids for MCL1

Sources for MCL1 Gene

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