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MCL1 Gene

protein-coding GIFtS: 65

GC01M148813

myeloid cell leukemia sequence 1 (BCL2-related)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BCL2L3 ^¹, ², ³
Bcl2-L-3 ^³
EAT ^²
MCL1L ^²
MCL1S ^²
MGC104264 ^²
MGC1839 ^²
Mcl-1 ^¹, ²
OTTHUMP00000032794 ^²
OTTHUMP00000032795 ^²
TM ^²
mcl1/EAT ^³

Descriptions
Bcl-2-like protein 3 ^³
Bcl-2-related protein EAT/mcl1 ^³
induced myeloid leukemia cell differentiation protein Mcl-1 ^²
myeloid cell leukemia sequence 1 ^²
myeloid cell leukemia sequence 1 (BCL2-related) ^²
myeloid cell leukemia sequence 1, isoform 1 ^²

External Ids
HGNC: 6943¹
Entrez Gene: 4170²
UniProtKB: Q07820³
Ensembl: ENSG00000143384⁷

Search outside databases for aliases for MCL1 gene

Previous GC identifers: GC01M148388 GC01M146294 GC01M147322 GC01M147763 GC01M147360

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MCL1:

The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this

locus and two transcript variants encoding distinct isoforms have been identified. The longer gene

product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced

shorter gene product (isoform 2) promotes apoptosis and is death-inducing. [provided by RefSeq]

UniProtKB/Swiss-Prot: MCL1_HUMAN, Q07820

Function: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of

viability but not of proliferation. Mediates its effects by interactions with a number of other

regulators of apoptosis. Isoform 1 inhibits apoptosis while isoform 2 promotes it

Gene Wiki entry for MCL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MCL1 gene

Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.2 HGNC cytogenetic band: 1q21

MCL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M148813: (about GC identifiers)

Start:	148,813,658 bp from pter
End:	148,818,760 bp from pter
Size:	5,103 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MCL1_HUMAN, Q07820 (See protein sequence)

Recommended Name: Induced myeloid leukemia cell differentiation protein Mcl-1

Size: 350 amino acids; 37337 Da

Subunit: Interacts with BAD, BOK, BIK and BFM (By similarity). Interacts with PMAIP1. Isoform 1

interacts with BAX, BAK1, TPT1 and BCL2L11. Heterodimer of isoform 1 and isoform 2. Homodimers of

isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro-apoptototic

BCL2-related proteins

Subcellular location: Membrane; Single-pass membrane protein (Potential). Cytoplasm. Mitochondrion.

Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria

PDB structures from and Proteopedia :

2NL9 (3D)

2NLA (3D)

2PQK (3D)

3D7V (3D)

Secondary accessions: B2R6B2 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1

Alternative splicing: 2 isoforms: Q07820-1 Q07820-2

Post-translational modifications:

Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127,

yielding a pro-apoptotic 28 kDa C-terminal fragment¹

Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region¹

Phosphorylated on Thr-163. Treatment with taxol or okadaic acid induces phosphorylation on

additional sites¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_068779.1 NP_877495.1

ENSEMBL proteins:

ENSP00000309973 ENSP00000358022

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for MCL1 (Mcl-1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MCL1)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	TAS	10837489
GO:0005739	mitochondrion	IEA	--
GO:0005741	mitochondrial outer membrane	TAS	10837489
GO:0016020	membrane	IEA	--

About this table

Antibodies for MCL1:

	Invitrogen Antibodies for MCL1
	Millipore Mono- and Polyclonal Antibodies for the study of MCL1
	Sigma-Aldrich Antibodies for MCL1
	R&D Systems Antibodies for MCL1 (Mcl-1)
	Cell Signaling Technology (CST) Antibodies for MCL1 (Mcl-1)
	Antibodies from Abcam (MCL1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MCL1)
	Novus Biologicals Antibodies for MCL1

Assays for MCL1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q07820

ProtoNet protein and cluster: Q07820

1 Blocks protein family: IPB000712 Apoptosis regulator Bcl-2 protein

UniProtKB/Swiss-Prot: MCL1_HUMAN, Q07820

Similarity: Belongs to the Bcl-2 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MCL1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MCL1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_021960

Applied Biosystems Silencer® siRNAs for MCL1

Sigma-Aldrich siRNA and siRNA Panels for MCL1

Sigma-Aldrich shRNA Panels and shRNA for MCL1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_021960
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_021960
untagged cDNA clones in CMV expression vector (see all 2): NM_021960

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_021960

UniProtKB/Swiss-Prot: MCL1_HUMAN, Q07820

Function: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of

viability but not of proliferation. Mediates its effects by interactions with a number of other

regulators of apoptosis. Isoform 1 inhibits apoptosis while isoform 2 promotes it

Induction: Expression increases early during phorbol-ester induced differentiation along the

monocyte/macrophage pathway in myeloid leukemia cell lines ML-1. Rapidly up-regulated by CSF2 in

ML-1 cells. Up-regulated by heat-shock induced differentiation. Expression increases early during

retinoic acid-induced differentiation

Genatlas biochemistry entry for MCL1:

myeloid cell leukemia 1,involved in programmed myeloid cell differentiation,with homology to BCL2

5 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Mcl1):

embryogenesis

hematopoietic system

immune system

lethality-prenatal/perinatal

normal

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IDA	10837489
GO:0015266	protein channel activity	TAS	10837489
GO:0046982	protein heterodimerization activity	IPI	10837489

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for MCL1

5/87 Interacting proteins for MCL1 (Q07820^{1, 2} ENSP00000358022³) via UniProtKB, MINT, and/or STRING (see all 87 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HUWE1	Q7Z6Z7², ENSP00000262854³	MINT-68753 MINT-68750 MINT-68749 MINT-68752 STRING (score=.951)
BAX	Q07812², ENSP00000293288³	MINT-4980279 MINT-4980319 STRING (score=.966)
BBC3	Q9BXH1¹, ENSP00000352999³	EBI-1003422, EBI-519884 STRING (score=.995)
PMAIP1	Q13794¹, ENSP00000269518³	EBI-1003422, EBI-707392 STRING (score=.992)
BIK	Q13323¹, ENSP00000216115³	EBI-1003422, EBI-700794 STRING (score=.97)

About this table

5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001709	cell fate determination	NAS	10837489
GO:0006916	anti-apoptosis	TAS	10837489
GO:0007275	multicellular organismal development	TAS	8790944
GO:0019725	cellular homeostasis	NAS	10837489
GO:0030154	cell differentiation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for MCL1:

Antagonist

Compounds for MCL1 available from Tocris Bioscience
10/31 Novoseek chemical compound relationships for MCL1 gene (see all 31 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
noxa	85.83	58	19372561 (7), 17018621 (4), 16782027 (3), 17971907 (3) (see all 23)
pd-184352	60.84	1	17218385 (1)
pd 98,059	48.06	13	12606824 (2), 11314001 (1), 12479056 (1), 10961875 (1) (see all 10)
[alcl]	46.88	8	15858125 (4), 17430669 (2)
epoxomicin	44.89	1	16876795 (1)
phosphatidylinositol	43.99	12	18036649 (2), 11368774 (2), 10454566 (1), 11390502 (1) (see all 10)
tyrosine	43.42	9	12438243 (1), 18088462 (1), 15753661 (1), 11767000 (1) (see all 9)
vanadate	42.97	1	12359245 (1)
wortmannin	36.51	10	11390502 (2), 12606824 (2), 11314001 (1), 17935137 (1) (see all 7)
bryostatin 1	34.10	4	15291360 (2), 16465244 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MCL1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MCL1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_021960

Sigma-Aldrich siRNA and siRNA Panels for MCL1

Sigma-Aldrich shRNA Panels and shRNA for MCL1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_021960 NM_182763

REFSEQ mRNAs for MCL1 gene (2 alternative transcripts):

NM_021960.3 NM_182763.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_021960 NM_182763

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_021960
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_021960
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_021960

Additional cDNA sequence:

AF118124.1 AF118276.1 AF118277.1 AF118278.1 AF203373.1 AK294462.1 AK297217.1 AK300499.1

AK304775.1 AK312508.1 AK316267.1 BC017197.2 BC071897.1 BC107735.1 BT006640.1 CR610973.1

CR618814.1 CR621920.1 CR625890.1 L08246.1

24/26 DOTS entries (see all 26 ):

DT.95301973 DT.449911 DT.95301975 DT.92454096 DT.92454081 DT.121443994 DT.100883419 DT.121443999

DT.92025156 DT.95301970 DT.95210901 DT.95301989 DT.95301980 DT.101964311 DT.121444038 DT.121443995

DT.121444001 DT.121444002 DT.121444016 DT.121444037 DT.40108891 DT.95301956 DT.99943281 DT.100883430

24/849 AceView cDNA sequences (see all 849 ):

CA310292 CB146739 BM725225 AW593473 CB852940 BI093508 AI582805 BU626282

CA421486 BE673943 BI492038 BM985298 AA040674 BM826993 AA521334 AA278892

BU615283 BM671008 BM818791 BQ012814 AA564590 BQ380037 AI601134 AA206920

highest scoring ESTs for MCL1:

L08246 AA012976 AA017360 AA035539 AA278299 AA283692 AA287559 AA287701 AA291667 AA305899

Unigene Cluster for MCL1:

Myeloid cell leukemia sequence 1 (BCL2-related)

Hs.719112 [show with all ESTs]

Unigene Representative Sequence: NM_021960

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for MCL1

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3a	·	3b
SP1:							-
SP2:							-		-
SP3:							-		-		-
SP4:

About this scheme

ECgene alternative splicing isoforms for MCL1

2 Ensembl transcripts including schematic representations:

ENST00000307940 ENST00000369026

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MCL1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MCL1

¹ / ² / ³

8 probe-sets matching MCL1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
277_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.98	L08246	1.00	1.00	1.00	1
33146_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.02	L08246	1.00	1.00	1.00	1
200797_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI275690	0.60	1.00	0.82	1
200798_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_021960	0.60	1.00	0.82	1
200796_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF594446	0.60	1.00	0.82	1
200797_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200798_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200796_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.719112
Expression variation in blood from EXPOLDB for MCL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MCL1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MCL1¹	--	myeloid cell leukemia sequence 1 (BCL2-related)	88.19(n) 87.71(a)	403537 NM_001003016.1 NP_001003016.1
chimpanzee (Pan troglodytes)	MCL1¹	--	myeloid cell leukemia sequence 1 (BCL2-related)	99.14(n) 99.42(a)	457274 XM_513776.2 XP_513776.2
cow (Bos taurus)	MCL1¹	--	myeloid cell leukemia sequence 1 (BCL2-related)	88.35(n) 88.54(a)	788087 XM_001255136.1 XP_001255137.1
rat (Rattus norvegicus)	Mcl1¹	--	myeloid cell leukemia sequence 1	82.12(n) 82.73(a)	60430 NM_021846.2 NP_068618.2
mouse (Mus musculus)	Mcl1^{1, 5}	3 (43.60 cM)⁵	myeloid cell leukemia sequence 1^{1, 5}	81.17(n)¹ 80.66(a)¹	17210¹ NM_008562.3¹ NP_032588.1¹ AA174356⁵ AF063886⁵ (see all 20)

About this table Species with no ortholog for MCL1

ENSEMBL Gene Tree for MCL1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/35 NCBI SNPs in MCL1 are shown (see all 35 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 50)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs878471^1,2	A,C,F,H	148814371(+)	`GGGCAG/ATTCTT`	2	--	ut3¹		16	NA EA MN EU WA NS	1184
	rs6587756^1,2	C,F,H	148813489(+)	`TAATTT/AGAATT`	2	--	ng5¹		7	EU EA WA NA	560
--	rs4970918^1,2	A,C,F	148819972(+)	`ggggtG/Agatct`	2	--	ng3¹		5	NS	144
--	rs6661538^1,2	C,F	148820069(+)	`gtgggG/Acagaa`	2	--	ng3¹		5	NS	150
--	rs1913116^1,2	C,F	148819586(-)	`CCCAGC/TTACTC`	2	--	ng3¹		5	NS	176
	rs35900369^1,2	F	148815106(-)	`GGTCTA/GAGCCT`	2	--	ut3¹		5	NS	190
--	rs34994736^1,2	F	148820283(-)	`TAAGAG/AGCTGA`	2	--	ng3¹		5	NS	150
--	rs35822171^1,2	F	148819819(-)	`AAAGCC/TTGTTT`	2	--	ng3¹		5	NS	168
	rs35392872^1,2	F	148814562(-)	`ATGCTC/TACTTA`	2	--	ut3¹		5	NS	186
	rs35176837^1,2	F	148814451(-)	`TCAGTC/TTCGGA`	2	--	ut3¹		5	NS	190

About this table

HapMap Linkage Disequilibrium images for MCL1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 159552

10/75 Novoseek disease relationships for MCL1 gene (see all 75 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphocytic leukemia chronic b-cell	68.89	5	14695629 (2), 19092849 (1), 15291360 (1), 15728130 (1)
leukemia lymphocytic chronic	68.77	10	15126604 (2), 19008456 (2), 12210808 (1), 18599795 (1) (see all 8)
leukemia	59.12	39	17909059 (2), 9446661 (2), 12149273 (2), 16109713 (2) (see all 26)
myeloma	58.62	39	15459900 (4), 10583232 (4), 15902294 (3), 10602002 (3) (see all 20)
tumors	54.91	100	8909234 (4), 9060818 (4), 16361547 (3), 17561513 (3) (see all 58)
myeloid leukemia	54.01	9	16761109 (3), 16806223 (1), 7682708 (1), 12788061 (1) (see all 7)
cancer	53.60	45	16761109 (2), 18399351 (2), 17495324 (2), 19099185 (2) (see all 32)
lymphoma	47.74	22	17430669 (2), 11389033 (2), 8080035 (1), 15854132 (1) (see all 16)
lymphoma follicular	47.21	6	16487175 (2), 15343511 (2), 12210808 (1), 7835896 (1)
myeloid leukemia chronic	47.20	7	17599053 (2), 18088462 (1), 17595328 (1), 15626746 (1) (see all 6)

About this table

Human Genome Epidemiology Navigator: MCL1 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/599 PubMed articles for MCL1 gene (see all 599 ):

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. (PubMed id 7682708)^{1, 2, 3, 4} Kozopas K.M.... Craig R.W. (1993)
MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. (PubMed id 10837489)^{1, 3, 4} Bae J.... Hsueh A.J.W. (2000)
Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and fortilin. The potential role of MCL1 as a fortilin chaperone. (PubMed id 12149273)^{1, 3, 4} Zhang D.... Fujise K. (2002)
Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage. (PubMed id 15122313)^{1, 3, 4} Michels J....Packham G. (2004)
Mcl-1 is an immediate-early gene activated by the granulocyte- macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response. (PubMed id 9671497)^{1, 3, 4} Chao J.-R....Yang-Yen H.-F. (1998)
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. (PubMed id 15989957)^{1, 3, 4} Zhong Q.... Wang X. (2005)
Human and mouse chromosomal mapping of the myeloid cell leukemia-1 gene: MCL1 maps to human chromosome 1q21, a region that is frequently altered in preneoplastic and neoplastic disease. (PubMed id 7835896)^{1, 2, 3} Craig R.W....Griffin C.A. (1994)
Exon skipping in Mcl-1 results in a Bcl-2 homology domain 3 only gene product that promotes cell death. (PubMed id 10766760)^{1, 3, 4} Bingle C.D....Whyte M.K.B. (2000)
Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. (PubMed id 15077116)^{1, 3, 4} Leu J.I.-J.... George D.L. (2004)
MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol. (PubMed id 15241487)^{1, 3, 4} Domina A.M.... Craig R.W. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4170	HGNC: 6943	AceView: MCL1	Ensembl:ENSG00000143384	euGenes: HUgn4170
ECgene: MCL1	H-InvDB: MCL1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MCL1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mcl1/

Licensable Technologies for MCL1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MCL1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MCL1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MCL1		Antibodies for MCL1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MCL1		Small molecules for MCL1
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Antibodies (MCL1)
	Chimera RNAi (MCL1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for MCL1 (Mcl-1)

	Recombinant Proteins (MCL1)
	Antibodies (MCL1)

Search OriGene for MCL1

Tocris compounds for MCL1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MCL1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
MCL1 Gene at Home site.
Version 2.41.1
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MCL1 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for MCL1

Summaries
for MCL1

Genomic Location
for MCL1

Proteins
for MCL1

Protein Domains/
Families
for MCL1

Gene Function
for MCL1

Pathways & Interactions
for MCL1

Drugs & Compounds
for MCL1

Transcripts
for MCL1

Expression
for MCL1

Orthologs
for MCL1

Paralogs
for MCL1

SNPs/Variants
for MCL1

Disorders & Mutations
for MCL1

Medical News
for MCL1

Publications
for MCL1

Search for MCL1

Genome Databases showing MCL1

Other Databases showing MCL1

Specialized Databases showing MCL1

Licensable Technologies
for MCL1

Services
for MCL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MCL1 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor MCL1

Summariesfor MCL1

Genomic Locationfor MCL1

Proteinsfor MCL1

Protein Domains/Familiesfor MCL1

Gene Functionfor MCL1

Pathways & Interactionsfor MCL1

Drugs & Compoundsfor MCL1

Transcriptsfor MCL1

Expression for MCL1

Orthologsfor MCL1

Paralogsfor MCL1

SNPs/Variantsfor MCL1

Disorders & Mutationsfor MCL1

Medical Newsfor MCL1

Publicationsfor MCL1

Search for MCL1

Genome Databases showing MCL1

Other Databases showing MCL1

Specialized Databases showing MCL1

Licensable Technologiesfor MCL1

Servicesfor MCL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MCL1

Summaries
for MCL1

Genomic Location
for MCL1

Proteins
for MCL1

Protein Domains/
Families
for MCL1

Gene Function
for MCL1

Pathways & Interactions
for MCL1

Drugs & Compounds
for MCL1

Transcripts
for MCL1

Expression
for MCL1

Orthologs
for MCL1

Paralogs
for MCL1

SNPs/Variants
for MCL1

Disorders & Mutations
for MCL1

Medical News
for MCL1

Publications
for MCL1

Licensable Technologies
for MCL1

Services
for MCL1