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Aliases for MCL1 Gene

Aliases for MCL1 Gene

  • Myeloid Cell Leukemia 1 2 3
  • Myeloid Cell Leukemia Sequence 1 (BCL2-Related) 2 3
  • Bcl-2-Related Protein EAT/Mcl1 3 4
  • Bcl-2-Like Protein 3 3 4
  • Bcl2-L-3 3 4
  • Mcl1/EAT 3 4
  • BCL2L3 3 4
  • Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 3
  • Myeloid Cell Leukemia ES 3
  • MCL1-ES 3
  • MCL1L 3
  • MCL1S 3
  • Mcl-1 3
  • EAT 3
  • TM 3

External Ids for MCL1 Gene

Previous GeneCards Identifiers for MCL1 Gene

  • GC01M148388
  • GC01M146294
  • GC01M147322
  • GC01M147763
  • GC01M147360
  • GC01M148813
  • GC01M150547
  • GC01M121925

Summaries for MCL1 Gene

Entrez Gene Summary for MCL1 Gene

  • This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]

GeneCards Summary for MCL1 Gene

MCL1 (Myeloid Cell Leukemia 1) is a Protein Coding gene. Diseases associated with MCL1 include cholangiocarcinoma and megalencephalic leukoencephalopathy with subcortical cysts. Among its related pathways are PI3K-Akt signaling pathway and MicroRNAs in cancer. GO annotations related to this gene include protein heterodimerization activity and protein channel activity.

UniProtKB/Swiss-Prot for MCL1 Gene

  • Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

Gene Wiki entry for MCL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCL1 Gene

Genomics for MCL1 Gene

Regulatory Elements for MCL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MCL1 Gene

Start:
150,574,551 bp from pter
End:
150,579,738 bp from pter
Size:
5,188 bases
Orientation:
Minus strand

Genomic View for MCL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCL1 Gene

Proteins for MCL1 Gene

  • Protein details for MCL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07820-MCL1_HUMAN
    Recommended name:
    Induced myeloid leukemia cell differentiation protein Mcl-1
    Protein Accession:
    Q07820
    Secondary Accessions:
    • B2R6B2
    • D3DV03
    • D3DV04
    • Q9HD91
    • Q9NRQ3
    • Q9NRQ4
    • Q9UHR7
    • Q9UHR8
    • Q9UHR9
    • Q9UNJ1

    Protein attributes for MCL1 Gene

    Size:
    350 amino acids
    Molecular mass:
    37337 Da
    Quaternary structure:
    • Interacts with HIF3A (via C-terminus domain) (By similarity). Interacts with BAD, BOK, BIK and BFM. Interacts with PMAIP1. Isoform 1 interacts with BAX, BAK1, TPT1 and BCL2L11. Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro-apoptotic BCL2-related proteins. Interacts with BOP. Interacts with BCL2L11; may sequester BCL2L11 to prevent its pro-apoptotic activity.

    Three dimensional structures from OCA and Proteopedia for MCL1 Gene

    Alternative splice isoforms for MCL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCL1 Gene

Proteomics data for MCL1 Gene at MOPED

Post-translational modifications for MCL1 Gene

  • Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment
  • Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.
  • Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region.
  • Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-159.
  • Ubiquitination at Lys5, Lys40, Lys136, Lys194, Lys197, and Lys308
  • Modification sites at PhosphoSitePlus

Other Protein References for MCL1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MCL1 (MCL1)

No data available for DME Specific Peptides for MCL1 Gene

Domains for MCL1 Gene

Suggested Antigen Peptide Sequences for MCL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q07820

UniProtKB/Swiss-Prot:

MCL1_HUMAN :
  • Q07820
Family:
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with MCL1: view

No data available for Gene Families for MCL1 Gene

Function for MCL1 Gene

Molecular function for MCL1 Gene

GENATLAS Biochemistry: myeloid cell leukemia 1,involved in programmed myeloid cell differentiation,with homology to BCL2
UniProtKB/Swiss-Prot Function: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
UniProtKB/Swiss-Prot Induction: Expression increases early during phorbol ester-induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell line ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat shock-induced differentiation. Expression increases early during retinoic acid-induced differentiation.

Gene Ontology (GO) - Molecular Function for MCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15901672
GO:0015266 protein channel activity TAS 10837489
GO:0042803 protein homodimerization activity IBA --
GO:0046982 protein heterodimerization activity IPI 10837489
GO:0051434 BH3 domain binding IPI 21036904
genes like me logo Genes that share ontologies with MCL1: view
genes like me logo Genes that share phenotypes with MCL1: view

Animal Models for MCL1 Gene

MGI Knock Outs for MCL1:

Animal Model Products

CRISPR Products

miRNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MCL1 Gene

Localization for MCL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCL1 Gene

Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCL1 Gene COMPARTMENTS Subcellular localization image for MCL1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20467439
GO:0005654 nucleoplasm IEA --
GO:0005737 cytoplasm TAS 10837489
GO:0005739 mitochondrion IDA 7896880
GO:0005741 mitochondrial outer membrane TAS 10837489
genes like me logo Genes that share ontologies with MCL1: view

Pathways for MCL1 Gene

genes like me logo Genes that share pathways with MCL1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for MCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001709 cell fate determination NAS 10837489
GO:0007275 multicellular organismal development IEA --
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA --
GO:0008637 apoptotic mitochondrial changes IEA --
GO:0019725 cellular homeostasis NAS 10837489
genes like me logo Genes that share ontologies with MCL1: view

Compounds for MCL1 Gene

(19) ApexBio Compounds for MCL1 Gene

Compound Action Cas Number
2,3-DCPE hydrochloride Selectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro. [418788-90-6]
ABT-199 Selective Bcl-2 inhibitor [1257044-40-8]
ABT-263 (Navitoclax) orally sellecitive inhibitor of Bcl-2 family proteins [923564-51-6]
ABT-737 novel and potent inhibitor of BCL-2 family proteins [852808-04-9]
Apogossypolone (ApoG2) pan Bcl-2 inhibitor [886578-07-0]
AT-101 R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 [90141-22-3]
Bax channel blocker Potent inhibitor of Bax-mediated mitochondrial cytochrome c release. [335165-68-9]
Bax inhibitor peptide P5 Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria [579492-83-4]
Bax inhibitor peptide V5 Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria [579492-81-2]
Bax inhibitor peptide, negative control Negative control peptide for the Bax inhibitor peptides V5 and P5 [1315378-74-5]
BM-1074 potent and efficacious Bcl-2/Bcl-xL inhibitor [1391108-10-3]
Gambogic Acid activates caspases with EC50 of 0.78-1.64 uM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 [2752-65-0]
HA14-1 non-peptidic ligand of a Bcl-2 [65673-63-4]
Marinopyrrole A novel and specific Mcl-1 inhibitor [1227962-62-0]
MIM1 Inhibitor of Mcl-1
Obatoclax mesylate (GX15-070) potently inhibits BCL-2 family [803712-79-0]
Sabutoclax pan-Bcl-2 inhibitor [1228108-65-3]
TW-37 potent small-molecule inhibitor of BCL-2 [877877-35-5]
WEHI-539 high affinity (subnanomolar) and selectivity for BCL-XL [1431866-33-9]

(87) Novoseek inferred chemical compound relationships for MCL1 Gene

Compound -log(P) Hits PubMed IDs
noxa 88.2 64
flavopiridol 77.6 24
roscovitine 68.5 14
pd-184352 68 4
bortezomib 67.1 17
genes like me logo Genes that share compounds with MCL1: view

Transcripts for MCL1 Gene

Unigene Clusters for MCL1 Gene

Myeloid cell leukemia sequence 1 (BCL2-related):
Representative Sequences:

CRISPR Products

miRNA Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for MCL1 Gene

GeneLoc Exon Structure for
MCL1
ECgene alternative splicing isoforms for
MCL1

Expression for MCL1 Gene

mRNA expression in normal human tissues for MCL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MCL1 Gene

This gene is overexpressed in Whole Blood (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCL1 Gene

SOURCE GeneReport for Unigene cluster for MCL1 Gene Hs.632486

genes like me logo Genes that share expressions with MCL1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MCL1 Gene

Orthologs for MCL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MCL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCL1 35
  • 99.14 (n)
  • 99.42 (a)
MCL1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 84 (a)
OneToMany
MCL1 35
  • 88.35 (n)
  • 88.54 (a)
MCL1 36
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MCL1 35
  • 88.19 (n)
  • 87.71 (a)
MCL1 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcl1 35
  • 81.17 (n)
  • 80.66 (a)
Mcl1 16
Mcl1 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCL1 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcl1 35
  • 82.12 (n)
  • 82.73 (a)
chicken
(Gallus gallus)
Aves MCL1 35
  • 64.98 (n)
  • 62.16 (a)
MCL1 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCL1 36
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii bcl2l10 36
  • 31 (a)
OneToMany
mcl1a 35
  • 51.38 (n)
  • 44.04 (a)
mcl1a 36
  • 36 (a)
OneToMany
mcl1b 36
  • 35 (a)
OneToMany
Species with no ortholog for MCL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MCL1 Gene

ENSEMBL:
Gene Tree for MCL1 (if available)
TreeFam:
Gene Tree for MCL1 (if available)

Paralogs for MCL1 Gene

Pseudogenes.org Pseudogenes for MCL1 Gene

genes like me logo Genes that share paralogs with MCL1: view

No data available for Paralogs for MCL1 Gene

Variants for MCL1 Gene

Sequence variations from dbSNP and Humsavar for MCL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9971 -- 150,579,317(-) CGCCA(G/T)ACTCC intron-variant, reference, missense
rs1802504 -- 150,579,159(-) GAAGA(G/T)GAGCT intron-variant, reference, missense
rs1913116 -- 150,580,486(-) CCCAG(C/T)TACTC upstream-variant-2KB
rs1913117 -- 150,580,058(-) CCGTC(C/T)TCTTC upstream-variant-2KB
rs2669072 -- 150,579,808(-) gcccc(C/G)gctca upstream-variant-2KB

Relevant External Links for MCL1 Gene

HapMap Linkage Disequilibrium report
MCL1
Human Gene Mutation Database (HGMD)
MCL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MCL1 Gene

Disorders for MCL1 Gene

(76) Novoseek inferred disease relationships for MCL1 Gene

Disease -log(P) Hits PubMed IDs
lymphocytic leukemia chronic b-cell 72.3 8
leukemia lymphocytic chronic 70.4 12
leukemia 62 40
myeloma 59.5 35
cancer 57.9 44

Relevant External Links for MCL1

Genetic Association Database (GAD)
MCL1
Human Genome Epidemiology (HuGE) Navigator
MCL1
genes like me logo Genes that share disorders with MCL1: view

No data available for UniProtKB/Swiss-Prot for MCL1 Gene

Publications for MCL1 Gene

  1. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. (PMID: 7682708) Kozopas K.M. … Craig R.W. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 23
  2. MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol. (PMID: 15241487) Domina A.M. … Craig R.W. (Oncogene 2004) 3 4 23
  3. Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage. (PMID: 15122313) Michels J. … Packham G. (Oncogene 2004) 3 4 23
  4. MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. (PMID: 10837489) Bae J. … Hsueh A.J.W. (J. Biol. Chem. 2000) 3 4 23
  5. Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and fortilin. The potential role of MCL1 as a fortilin chaperone. (PMID: 12149273) Zhang D. … Fujise K. (J. Biol. Chem. 2002) 3 4 23

Products for MCL1 Gene

  • Addgene plasmids for MCL1

Sources for MCL1 Gene

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