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Aliases for MCIDAS Gene

Aliases for MCIDAS Gene

  • Multiciliate Differentiation And DNA Synthesis Associated Cell Cycle Protein 2 3 5
  • Multiciliate Cell Differentiation 1 2 3
  • Protein Idas 3 4
  • Multicilin 2 3
  • MCIN 3 4
  • IDAS 3 4
  • MCI 3 4
  • Multiciliate Differentiation And DNA Synthesis-Associated Cell Cycle Protein 4

External Ids for MCIDAS Gene

Previous HGNC Symbols for MCIDAS Gene

  • MCIN

Previous GeneCards Identifiers for MCIDAS Gene

  • GC05M054521

Summaries for MCIDAS Gene

Entrez Gene Summary for MCIDAS Gene

  • This gene encodes a member of the geminin family of proteins. The encoded nuclear protein is required for the generation of multiciliated cells in respiratory epithelium. Mutations in this gene cause a rare mucociliary clearance disorder associated with recurring respiratory infections in human patients, known as reduced generation of multiple motile cilia (RGMC). [provided by RefSeq, Sep 2016]

GeneCards Summary for MCIDAS Gene

MCIDAS (Multiciliate Differentiation And DNA Synthesis Associated Cell Cycle Protein) is a Protein Coding gene. Diseases associated with MCIDAS include Mucociliary Clearance Disorder and Kartagener Syndrome. GO annotations related to this gene include identical protein binding and transcription coactivator activity.

UniProtKB/Swiss-Prot for MCIDAS Gene

  • Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway (PubMed:25048963). Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1 (PubMed:21543332, PubMed:24064211).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCIDAS Gene

Genomics for MCIDAS Gene

Regulatory Elements for MCIDAS Gene

Enhancers for MCIDAS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G055226 1.1 ENCODE 0.7 +0.2 200 2.2 PKNOX1 ARID4B SIN3A ZNF2 ZNF143 ZNF263 SP3 REST SMARCB1 CBX8 LOC105378973 CCNO MCIDAS PIR50338
GH05G055231 0.6 Ensembl 0.7 -4.3 -4286 0.4 CTCF RNF2 SUZ12 CBX2 ATF2 SCRT2 CTBP2 ZNF24 ZBTB33 EZH2 CCNO MCIDAS
GH05G055232 1 ENCODE 0.4 -6.3 -6326 3.3 ATF1 SIN3A GLI4 ZNF2 ZNF121 GLIS2 ZNF263 SP3 CBX8 ZNF610 LOC105378973 CCNO MCIDAS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MCIDAS on UCSC Golden Path with GeneCards custom track

Promoters for MCIDAS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000180734 15 201 ATF1 SIN3A ZNF121 GLIS2 KDM4B ZNF263 SMARCB1 GLIS1 KDM1A SETDB1

Genomic Location for MCIDAS Gene

Chromosome:
5
Start:
55,219,597 bp from pter
End:
55,227,315 bp from pter
Size:
7,719 bases
Orientation:
Minus strand

Genomic View for MCIDAS Gene

Genes around MCIDAS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCIDAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCIDAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCIDAS Gene

Proteins for MCIDAS Gene

  • Protein details for MCIDAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    D6RGH6-MCIN_HUMAN
    Recommended name:
    Multicilin
    Protein Accession:
    D6RGH6
    Secondary Accessions:
    • C9JGY3
    • D6R920
    • F8KGQ8

    Protein attributes for MCIDAS Gene

    Size:
    385 amino acids
    Molecular mass:
    41720 Da
    Quaternary structure:
    • Heterodimer (via coiled-coil domain) with GMNN (via coiled-coil domain); targets GMNN to the nucleus. Can form homodimers (in vitro, via coiled-coil domain), but these are much less stable than the heterodimer formed with GMNN.
    Miscellaneous:
    • Was named Idas in reference to the cousin of the Gemini in ancient Greek mythology.

    Three dimensional structures from OCA and Proteopedia for MCIDAS Gene

neXtProt entry for MCIDAS Gene

Post-translational modifications for MCIDAS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MCIDAS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MCIDAS Gene

Domains & Families for MCIDAS Gene

Protein Domains for MCIDAS Gene

Suggested Antigen Peptide Sequences for MCIDAS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

D6RGH6

UniProtKB/Swiss-Prot:

MCIN_HUMAN :
  • Belongs to the geminin family.
Family:
  • Belongs to the geminin family.
genes like me logo Genes that share domains with MCIDAS: view

No data available for Gene Families for MCIDAS Gene

Function for MCIDAS Gene

Molecular function for MCIDAS Gene

UniProtKB/Swiss-Prot Function:
Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway (PubMed:25048963). Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1 (PubMed:21543332, PubMed:24064211).

Gene Ontology (GO) - Molecular Function for MCIDAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IEA --
GO:0005515 protein binding IPI 21543332
GO:0042802 identical protein binding IPI 21543332
genes like me logo Genes that share ontologies with MCIDAS: view

Phenotypes for MCIDAS Gene

genes like me logo Genes that share phenotypes with MCIDAS: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCIDAS Gene

Localization for MCIDAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCIDAS Gene

Nucleus. Note=Excluded from the nucleolus. {ECO:0000269 PubMed:21543332}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCIDAS gene
Compartment Confidence
nucleus 5
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MCIDAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21543332
GO:0005730 NOT nucleolus IDA 21543332
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with MCIDAS: view

Pathways & Interactions for MCIDAS Gene

SuperPathways for MCIDAS Gene

No Data Available

Interacting Proteins for MCIDAS Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000426359%0d%0a9606.ENSP00000230056%0d%0a
Selected Interacting proteins: D6RGH6-MCIN_HUMAN ENSP00000426359 for MCIDAS Gene via IID STRING UniProtKB

Gene Ontology (GO) - Biological Process for MCIDAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006275 regulation of DNA replication IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007049 cell cycle IEA --
GO:0007346 regulation of mitotic cell cycle IEA,IMP 21543332
genes like me logo Genes that share ontologies with MCIDAS: view

No data available for Pathways by source and SIGNOR curated interactions for MCIDAS Gene

Drugs & Compounds for MCIDAS Gene

(2) Drugs for MCIDAS Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 2050
Fludarabine Approved Pharma DNA synthsis inhibitor 1154,1154

(2) ApexBio Compounds for MCIDAS Gene

Compound Action Cas Number
Carboplatin Antitumor agent that forms platinum-DNA adducts. 41575-94-4
Fludarabine DNA synthsis inhibitor 21679-14-1
genes like me logo Genes that share compounds with MCIDAS: view

Drug Products

Transcripts for MCIDAS Gene

mRNA/cDNA for MCIDAS Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MCIDAS Gene

Multiciliate differentiation and DNA synthesis associated cell cycle protein:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCIDAS Gene

No ASD Table

Relevant External Links for MCIDAS Gene

GeneLoc Exon Structure for
MCIDAS
ECgene alternative splicing isoforms for
MCIDAS

Expression for MCIDAS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MCIDAS Gene

mRNA differential expression in normal tissues according to GTEx for MCIDAS Gene

This gene is overexpressed in Stomach (x10.6), Thyroid (x6.7), Pancreas (x5.5), and Bladder (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of MCIDAS Gene:

MCIDAS

SOURCE GeneReport for Unigene cluster for MCIDAS Gene:

Hs.394578

Evidence on tissue expression from TISSUES for MCIDAS Gene

  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with MCIDAS: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCIDAS Gene

Orthologs for MCIDAS Gene

This gene was present in the common ancestor of chordates.

Orthologs for MCIDAS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCIN 34
  • 99.57 (n)
MCIDAS 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCIDAS 35 34
  • 88.19 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MCIDAS 35 34
  • 86.63 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mcidas 16 35 34
  • 81.29 (n)
rat
(Rattus norvegicus)
Mammalia Mcidas 34
  • 80.21 (n)
oppossum
(Monodelphis domestica)
Mammalia MCIDAS 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves MCIDAS 35
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCIDAS 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mci 34
  • 59.12 (n)
Species where no ortholog for MCIDAS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MCIDAS Gene

ENSEMBL:
Gene Tree for MCIDAS (if available)
TreeFam:
Gene Tree for MCIDAS (if available)

Paralogs for MCIDAS Gene

No data available for Paralogs for MCIDAS Gene

Variants for MCIDAS Gene

Sequence variations from dbSNP and Humsavar for MCIDAS Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs777031813 Pathogenic 55,222,341(+) ATGTC(G/T)CAAGG reference, stop-gained
rs797045151 Pathogenic 55,220,427(-) CCAGG(A/G)CAATG reference, missense
rs797045152 Pathogenic 55,220,382(-) GTTCC(A/G/T)CTGGG reference, missense
rs186341559 Likely benign 55,227,016(+) CGCCC(C/T)ACCTT intron-variant, upstream-variant-2KB
rs375687696 Likely benign 55,220,462(+) CTGTG(A/G)CTGCG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MCIDAS Gene

Variant ID Type Subtype PubMed ID
nsv1027090 CNV gain 25217958
nsv830302 CNV gain 17160897

Variation tolerance for MCIDAS Gene

Gene Damage Index Score: 1.44; 28.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCIDAS Gene

Human Gene Mutation Database (HGMD)
MCIDAS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCIDAS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCIDAS Gene

Disorders for MCIDAS Gene

MalaCards: The human disease database

(9) MalaCards diseases for MCIDAS Gene - From: ClinVar, GeneTests, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MCIDAS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCIDAS
genes like me logo Genes that share disorders with MCIDAS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MCIDAS Gene

Publications for MCIDAS Gene

  1. Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression. (PMID: 21543332) Pefani D.E. … Lygerou Z. (J. Biol. Chem. 2011) 2 3 4 64
  2. MCIDAS mutations result in a mucociliary clearance disorder with reduced generation of multiple motile cilia. (PMID: 25048963) Boon M. … Omran H. (Nat. Commun. 2014) 3 4 64
  3. The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing. (PMID: 24064211) Caillat C. … Perrakis A. (J. Biol. Chem. 2013) 3 4 64
  4. Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation. (PMID: 22231168) Stubbs J.L. … Kintner C. (Nat. Cell Biol. 2012) 2 3 64
  5. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4 64

Products for MCIDAS Gene

Sources for MCIDAS Gene

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