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Aliases for MCIDAS Gene

Aliases for MCIDAS Gene

  • Multiciliate Differentiation And DNA Synthesis Associated Cell Cycle Protein 2 3
  • IDAS 3 4 6
  • Multiciliate Differentiation And DNA Synthesis-Associated Cell Cycle Protein 3 4
  • Multiciliate Cell Differentiation 1 2 3
  • Protein Idas 3 4
  • Multicilin 2 3
  • MCIN 3 4
  • MCI 3 4

External Ids for MCIDAS Gene

Previous HGNC Symbols for MCIDAS Gene

  • MCIN

Previous GeneCards Identifiers for MCIDAS Gene

  • GC05M054521

Summaries for MCIDAS Gene

GeneCards Summary for MCIDAS Gene

MCIDAS (Multiciliate Differentiation And DNA Synthesis Associated Cell Cycle Protein) is a Protein Coding gene. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for MCIDAS Gene

  • Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway (PubMed:25048963). Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1 (PubMed:21543332, PubMed:24064211).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCIDAS Gene

Genomics for MCIDAS Gene

Genomic Location for MCIDAS Gene

Start:
55,219,597 bp from pter
End:
55,227,315 bp from pter
Size:
7,719 bases
Orientation:
Minus strand

Genomic View for MCIDAS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCIDAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCIDAS Gene

No data available for Regulatory Elements for MCIDAS Gene

Proteins for MCIDAS Gene

  • Protein details for MCIDAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    D6RGH6-MCIN_HUMAN
    Recommended name:
    Multicilin
    Protein Accession:
    D6RGH6
    Secondary Accessions:
    • C9JGY3
    • D6R920
    • F8KGQ8

    Protein attributes for MCIDAS Gene

    Size:
    385 amino acids
    Molecular mass:
    41720 Da
    Quaternary structure:
    • Heterodimer (via coiled-coil domain) with GMNN (via coiled-coil domain); targets GMNN to the nucleus. Can form homodimers (in vitro, via coiled-coil domain), but these are much less stable than the heterodimer formed with GMNN.
    Miscellaneous:
    • Was named Idas in reference to the cousin of the Gemini in ancient Greek mythology.

    Three dimensional structures from OCA and Proteopedia for MCIDAS Gene

neXtProt entry for MCIDAS Gene

Proteomics data for MCIDAS Gene at MOPED

Post-translational modifications for MCIDAS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MCIDAS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MCIDAS Gene

Domains for MCIDAS Gene

Protein Domains for MCIDAS Gene

Graphical View of Domain Structure for InterPro Entry

D6RGH6

UniProtKB/Swiss-Prot:

MCIN_HUMAN :
  • D6RGH6
Family:
  • Belongs to the geminin family.
genes like me logo Genes that share domains with MCIDAS: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MCIDAS Gene

Function for MCIDAS Gene

Molecular function for MCIDAS Gene

UniProtKB/Swiss-Prot Function: Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway (PubMed:25048963). Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1 (PubMed:21543332, PubMed:24064211).

Gene Ontology (GO) - Molecular Function for MCIDAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IEA --
GO:0005515 protein binding IPI 21543332
GO:0042802 identical protein binding IPI 21543332
genes like me logo Genes that share ontologies with MCIDAS: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MCIDAS Gene

Localization for MCIDAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCIDAS Gene

Nucleus. Note=Excluded from the nucleolus. {ECO:0000269 PubMed:21543332}.

Gene Ontology (GO) - Cellular Components for MCIDAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21543332
GO:0005730 NOT nucleolus IDA 21543332
genes like me logo Genes that share ontologies with MCIDAS: view

No data available for Subcellular locations from COMPARTMENTS for MCIDAS Gene

Pathways for MCIDAS Gene

SuperPathways for MCIDAS Gene

No Data Available

Interacting Proteins for MCIDAS Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000426359%0d%0a9606.ENSP00000230056%0d%0a
Selected Interacting proteins: ENSP00000426359 D6RGH6-MCIN_HUMAN for MCIDAS Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for MCIDAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006275 regulation of DNA replication IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007049 cell cycle IEA --
GO:0007346 regulation of mitotic cell cycle IMP 21543332
GO:0042384 cilium assembly ISS --
genes like me logo Genes that share ontologies with MCIDAS: view

No data available for Pathways by source for MCIDAS Gene

Compounds for MCIDAS Gene

(22) ApexBio Compounds for MCIDAS Gene

Compound Action Cas Number
Bleomycin Sulfate Chemotherapy agent, induces DNA strand break [9041-93-4]
Carboplatin Antitumor agent that forms platinum-DNA adducts. [41575-94-4]
Carmofur cytostatic derivative of fluorouracil. [61422-45-5]
Cladribine deoxyadenosine analog that induces apoptosis in CLL cells. [4291-63-8]
Clofarabine Deoxycytidine kinase (dCK) substrate. [123318-82-1]
CX-5461 Potent and selective inhibitor of Pol I-mediated rRNA synthesis [1138549-36-6]
Cyclophosphamide Nitrogen mustard alkylating agent and prodrug. [50-18-0]
Cytarabine inhibits DNA polymerases alpha, delta, and epsilon , and RNA polymerases resulting in suppression of DNA synthesis and repair. [147-94-4]
Dacarbazine Used as an antineoplastic in the treatment of malignant melanoma and sarcomas. [4342-3-4]
Daptomycin Calcium-dependent antibiotic. [103060-53-3]
Epirubicin HCl Antibiotic antitumor agent. [56390-09-1]
Floxuridine Antineoplastic antimetabolite. [50-91-9]
Fludarabine Chemotherapy agent [21679-14-1]
Gemcitabine Gemcitabine is a widely used antitumor agents in both clinics and research labs. [95058-81-4]
Gemcitabine HCl inhibits DNA synthesis [122111-03-9]
Ifosfamide Cytostatic agent that is structurally related to cyclophosphamide. [3778-73-2]
Mercaptopurine (6-MP) Inhibitor of de novo purine synthesis through interference with DNA and RNA synthesis. [50-44-2]
Mitomycin C Antibiotic and antitumor agent. [50-07-7]
Nelarabine Chemotherapy drug used in T-cell acute lymphoblastic leukemia. [121032-29-9]
Paradol active flavor constituent of the seeds of Guinea pepper [27113-22-0]
Rifaximin (Xifaxan) inhibits RNA synthesis and acts as a PXR (pregnane-X-receptor) activator. [80621-81-4]
VAL-083 bi-functional alkylating agent [23261-20-3]
genes like me logo Genes that share compounds with MCIDAS: view

Transcripts for MCIDAS Gene

mRNA/cDNA for MCIDAS Gene

(10) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MCIDAS Gene

Multiciliate differentiation and DNA synthesis associated cell cycle protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MCIDAS Gene

No ASD Table

Relevant External Links for MCIDAS Gene

GeneLoc Exon Structure for
MCIDAS
ECgene alternative splicing isoforms for
MCIDAS

Expression for MCIDAS Gene

mRNA expression in normal human tissues for MCIDAS Gene

mRNA differential expression in normal tissues according to GTEx for MCIDAS Gene

This gene is overexpressed in Stomach (10.6), Thyroid (6.7), Pancreas (5.5), and Bladder (4.8).

SOURCE GeneReport for Unigene cluster for MCIDAS Gene Hs.394578

genes like me logo Genes that share expressions with MCIDAS: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for MCIDAS Gene

Orthologs for MCIDAS Gene

This gene was present in the common ancestor of chordates.

Orthologs for MCIDAS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCIDAS 36
  • 99 (a)
OneToOne
MCIN 35
  • 99.57 (n)
  • 99.74 (a)
cow
(Bos Taurus)
Mammalia MCIDAS 35
  • 86.63 (n)
  • 84.76 (a)
MCIDAS 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCIDAS 35
  • 88.19 (n)
  • 88.28 (a)
MCIDAS 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcidas 35
  • 81.29 (n)
  • 79.26 (a)
Mcidas 16
Mcidas 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCIDAS 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcidas 35
  • 80.21 (n)
  • 79.42 (a)
chicken
(Gallus gallus)
Aves MCIDAS 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCIDAS 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mci 35
  • 59.12 (n)
  • 52.49 (a)
Species with no ortholog for MCIDAS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MCIDAS Gene

ENSEMBL:
Gene Tree for MCIDAS (if available)
TreeFam:
Gene Tree for MCIDAS (if available)

Paralogs for MCIDAS Gene

No data available for Paralogs for MCIDAS Gene

Variants for MCIDAS Gene

Sequence variations from dbSNP and Humsavar for MCIDAS Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs179795 -- 55,223,715(+) CCCCA(C/T)CCATG intron-variant
rs334876 -- 55,222,007(+) TTAAC(C/G)AATTT intron-variant
rs334877 -- 55,222,859(+) GGGTT(C/T)ACCAC intron-variant
rs334878 -- 55,224,050(+) GAAGC(A/G)GCAGG intron-variant
rs334879 -- 55,224,319(+) TTTGC(A/G)CTCAT intron-variant

Relevant External Links for MCIDAS Gene

HapMap Linkage Disequilibrium report
MCIDAS
Human Gene Mutation Database (HGMD)
MCIDAS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MCIDAS Gene

Disorders for MCIDAS Gene

UniProtKB/Swiss-Prot

MCIN_HUMAN
  • Note=Ciliary dyskinesia, primary (CILDN): A disorder characterized by abnormalities of motile cilia. Chronic recurrent infections of the upper (rhinitis, otitis media, nasal polyps and sinusitis) and lower airways (recurrent pneumonia, bronchiectasis, chronic obstructive airway disease caused by mucociliary clearance). The disease is caused by mutations affecting the gene represented in this entry. Respiratory epithelial cells carry only one or two cilia per cell. {ECO:0000269 PubMed:25048963}.

No disorders were found for MCIDAS Gene.

Publications for MCIDAS Gene

  1. Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression. (PMID: 21543332) Pefani D.E. … Lygerou Z. (J. Biol. Chem. 2011) 2 3 4
  2. Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation. (PMID: 22231168) Stubbs J.L. … Kintner C. (Nat. Cell Biol. 2012) 2 3
  3. The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing. (PMID: 24064211) Caillat C. … Perrakis A. (J. Biol. Chem. 2013) 3 4
  4. MCIDAS mutations result in a mucociliary clearance disorder with reduced generation of multiple motile cilia. (PMID: 25048963) Boon M. … Omran H. (Nat. Commun. 2014) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4

Products for MCIDAS Gene

  • antibodies-online peptides for MCIDAS
  • antibodies-online antibodies for MCIDAS
  • antibodies-online kits for MCIDAS

Sources for MCIDAS Gene

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