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Aliases for MCHR2 Gene

Aliases for MCHR2 Gene

  • Melanin-Concentrating Hormone Receptor 2 2 3
  • MCH2R 3 4 6
  • MCH2 3 4 6
  • SLT 3 4 6
  • G Protein-Coupled Receptor 145 2 3
  • G-Protein Coupled Receptor 145 3 4
  • MCH Receptor 2 3 4
  • GPR145 3 4
  • GPRv17 3 4
  • MCH-2R 3 4
  • MCH-R2 3 4
  • MCHR-2 3 4
  • Melanin-Concentrating Hormone 2 3
  • G Protein-Coupled Receptor Slt 3

External Ids for MCHR2 Gene

Previous HGNC Symbols for MCHR2 Gene

  • GPR145

Previous GeneCards Identifiers for MCHR2 Gene

  • GC06M100476
  • GC06M100367
  • GC06M097807

Summaries for MCHR2 Gene

GeneCards Summary for MCHR2 Gene

MCHR2 (Melanin-Concentrating Hormone Receptor 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for MCHR2 Gene

  • Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis

Tocris Summary for MCHR2 Gene

  • Melanin-concentrating hormone (MCH) is a neuropeptide that is expressed in the central and peripheral nervous systems and plays an important role in the control of feeding behaviors and energy metabolism. MCH acts on two GPCRs; MCH1 (GPR24) and MCH2 (GPR145). MCH1 and MCH2 have very similar tissue distribution patterns and are expressed in many brain regions, particularly the ventromedial, dorsalmedial and arcuate nuclei of the hypothalamus and zona incerta. They are also found at lower levels in the periphery including in the pituitary gland, adipose tissue and pancreas. MCH1 is a target for the orexigenic peptide leptin, which supports a role for MCH receptors in the control of food intake and energy expenditure. The human genes encoding MCH1 and MCH2 are localized to chromosomes 22q13.3 and 6q21 respectively. MCH2 is a pseudogene in rodents.

Gene Wiki entry for MCHR2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCHR2 Gene

Genomics for MCHR2 Gene

Regulatory Elements for MCHR2 Gene

Transcription factor binding sites by QIAGEN in the MCHR2 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MCHR2 Gene

Start:
99,919,910 bp from pter
End:
99,994,247 bp from pter
Size:
74,338 bases
Orientation:
Minus strand

Genomic View for MCHR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCHR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCHR2 Gene

Proteins for MCHR2 Gene

  • Protein details for MCHR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969V1-MCHR2_HUMAN
    Recommended name:
    Melanin-concentrating hormone receptor 2
    Protein Accession:
    Q969V1
    Secondary Accessions:
    • B3KVW4
    • E1P5D7
    • Q5VTV7
    • Q6Q377
    • Q9BXA8

    Protein attributes for MCHR2 Gene

    Size:
    340 amino acids
    Molecular mass:
    38849 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MCHR2 Gene

Proteomics data for MCHR2 Gene at MOPED

Post-translational modifications for MCHR2 Gene

Other Protein References for MCHR2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MCHR2 Gene

Domains for MCHR2 Gene

Gene Families for MCHR2 Gene

HGNC:
  • MCHR :GPCR / Class A : MCH receptors
IUPHAR :

Protein Domains for MCHR2 Gene

Suggested Antigen Peptide Sequences for MCHR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969V1

UniProtKB/Swiss-Prot:

MCHR2_HUMAN :
  • Q969V1
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with MCHR2: view

Function for MCHR2 Gene

Molecular function for MCHR2 Gene

UniProtKB/Swiss-Prot Function: Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis

Gene Ontology (GO) - Molecular Function for MCHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with MCHR2: view

Animal Model Products

CRISPR Products

miRNA for MCHR2 Gene

miRTarBase miRNAs that target MCHR2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MCHR2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MCHR2 Gene

Localization for MCHR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCHR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCHR2 Gene COMPARTMENTS Subcellular localization image for MCHR2 gene
Compartment Confidence
plasma membrane 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for MCHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MCHR2: view

Pathways for MCHR2 Gene

genes like me logo Genes that share pathways with MCHR2: view

Pathways by source for MCHR2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat

Gene Ontology (GO) - Biological Process for MCHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with MCHR2: view

Compounds for MCHR2 Gene

(5) Tocris Compounds for MCHR2 Gene

Compound Action Cas Number
MCH (human, mouse, rat) Potent endogenous MCH agonist [128315-56-0]
ATC 0175 hydrochloride MCH1 antagonist; also 5-HT2B antagonist and 5-HT1A partial agonist [510733-97-8]
GW 803430 MCH1 antagonist [515141-51-2]
SNAP 94847 hydrochloride Potent and selective MCH1 antagonist [487051-12-7]
TC-MCH 7c Selective melanin-concentrating hormone receptor 1 (MCH1R) antagonist [864756-35-4]

(6) IUPHAR Ligand for MCHR2 Gene

Ligand Type Action Affinity Pubmed IDs
[Phe13,Tyr19]MCH Agonist Full agonist 9.2
melanin-concentrating hormone Agonist Full agonist 9.2
Ac-hMCH-(6-16)-NH2 Agonist Full agonist 8.8
[Ava9,10,Ava14,15]-Ac-hMCH6-16-NH2 Antagonist Antagonist 7.3
MCH (salmon) Agonist Full agonist 7.1
ATC0065 Antagonist Antagonist 5.9

(1) Novoseek inferred chemical compound relationships for MCHR2 Gene

Compound -log(P) Hits PubMed IDs
calcium 23.5 4
genes like me logo Genes that share compounds with MCHR2: view

Transcripts for MCHR2 Gene

mRNA/cDNA for MCHR2 Gene

(12) Selected AceView cDNA sequences:
(9) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MCHR2 Gene

Melanin-concentrating hormone receptor 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MCHR2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCHR2 Gene

No ASD Table

Relevant External Links for MCHR2 Gene

GeneLoc Exon Structure for
MCHR2
ECgene alternative splicing isoforms for
MCHR2

Expression for MCHR2 Gene

mRNA expression in normal human tissues for MCHR2 Gene

mRNA differential expression in normal tissues according to GTEx for MCHR2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (17.7), Brain - Cortex (12.9), and Brain - Anterior cingulate cortex (BA24) (11.6).

SOURCE GeneReport for Unigene cluster for MCHR2 Gene Hs.591342

mRNA Expression by UniProt/SwissProt for MCHR2 Gene

Q969V1-MCHR2_HUMAN
Tissue specificity: Specifically expressed in the brain, with highest levels in cerebral cortex, hippocampus and amygdala. No expression detected in the cerebellum, thalamus or hypothalamus
genes like me logo Genes that share expressions with MCHR2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for MCHR2 Gene

Orthologs for MCHR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MCHR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCHR2 35
  • 99.51 (n)
  • 99.41 (a)
MCHR2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MCHR2 35
  • 87.52 (n)
  • 82.34 (a)
MCHR2 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCHR2 35
  • 90.24 (n)
  • 90.83 (a)
MCHR2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCHR2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCHR2 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR151 36
  • 21 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 24 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mchr2 35
  • 70.99 (n)
  • 74.04 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100150764 35
  • 65.21 (n)
  • 66.78 (a)
mchr2 36
  • 33 (a)
OneToMany
MCHR2 (1 of 3) 36
  • 63 (a)
OneToMany
MCHR2 (3 of 3) 36
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta AlCR2 36
  • 17 (a)
ManyToMany
star1 36
  • 18 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea npr-24 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 16 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
Species with no ortholog for MCHR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MCHR2 Gene

ENSEMBL:
Gene Tree for MCHR2 (if available)
TreeFam:
Gene Tree for MCHR2 (if available)

Paralogs for MCHR2 Gene

Selected SIMAP similar genes for MCHR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MCHR2: view

Variants for MCHR2 Gene

Sequence variations from dbSNP and Humsavar for MCHR2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2001456 -- 99,991,133(+) GGTGC(A/G)GGCAT intron-variant
rs2397435 -- 99,940,380(+) agtaa(C/T)ttttt intron-variant
rs2397662 -- 99,956,717(+) AAAAG(C/T)GTTGT intron-variant
rs2397681 -- 99,925,708(+) tttgt(A/C)ccccc intron-variant
rs2397682 -- 99,925,752(+) ttatt(C/G)tatta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCHR2 Gene

Variant ID Type Subtype PubMed ID
nsv886441 CNV Gain 21882294
esv2752086 CNV Gain 17911159
esv269139 CNV Insertion 20981092
esv2659885 CNV Deletion 23128226
esv272904 CNV Insertion 20981092
esv270014 CNV Insertion 20981092
esv1423203 CNV Insertion 17803354

Relevant External Links for MCHR2 Gene

HapMap Linkage Disequilibrium report
MCHR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCHR2 Gene

Disorders for MCHR2 Gene

(1) Novoseek inferred disease relationships for MCHR2 Gene

Disease -log(P) Hits PubMed IDs
obesity 21.1 5

Relevant External Links for MCHR2

Genetic Association Database (GAD)
MCHR2
Human Genome Epidemiology (HuGE) Navigator
MCHR2
genes like me logo Genes that share disorders with MCHR2: view

No data available for UniProtKB/Swiss-Prot for MCHR2 Gene

Publications for MCHR2 Gene

  1. Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor. (PMID: 11355873) Mori M. … Fujino M. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23
  2. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. (PMID: 11404457) Sailer A.W. … Liu Q. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4 23
  3. Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity. (PMID: 17698913) Ghoussaini M. … Meyre D. (J. Clin. Endocrinol. Metab. 2007) 3 23 48
  4. Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, MCH-R2. (PMID: 11459838) Wang S. … Hawes B.E. (J. Biol. Chem. 2001) 3 4 23
  5. Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2. (PMID: 15340116) Hawes B.E. … Simon J.S. (Obes. Res. 2004) 3 4 23

Products for MCHR2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MCHR2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for MCHR2
  • Block miRNA regulation of MCHR2 using miScript Target Protectors

Sources for MCHR2 Gene

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