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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MCHR2 Gene

protein-coding   GIFtS: 57
GCID: GC06M100367

Melanin-Concentrating Hormone Receptor 2

(Previous name: G protein-coupled receptor 145)
(Previous symbol: GPR145)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Melanin-Concentrating Hormone Receptor 21 2     MCH-2R2 3
GPR1451 2 3     MCH-R22 3
MCH22 3 5     MCHR-22 3
MCH2R2 3 5     G-Protein Coupled Receptor 1452 3
SLT2 3 5     MCH Receptor 22 3
G Protein-Coupled Receptor 1451 2     G Protein-Coupled Receptor Slt2
GPRv172 3     Melanin-Concentrating Hormone 22

External Ids:    HGNC: 208671   Entrez Gene: 845392   Ensembl: ENSG000001520347   OMIM: 6061115   UniProtKB: Q969V13   

Export aliases for MCHR2 gene to outside databases

Previous GC identifers: GC06M100476 GC06M097807


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MCHR2 Gene: 
MCHR2 (melanin-concentrating hormone receptor 2) is a protein-coding gene. Diseases associated with MCHR2 include hemolytic-uremic syndrome, and shigellosis, and among its related super-pathways are GPCR ligand binding and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is SSTR3.

UniProtKB/Swiss-Prot: MCHR2_HUMAN, Q969V1
Function: Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide
hydrolysis

summary for MCHR2 Gene:
Melanin-concentrating hormone (MCH) is a neuropeptide that is expressed in the central and peripheral
nervous systems and plays an important role in the control of feeding behaviors and energy metabolism. MCH
acts on two GPCRs; MCH1 (GPR24) and MCH2 (GPR145). MCH1 and MCH2 have very similar tissue distribution
patterns and are expressed in many brain regions, particularly the ventromedial, dorsalmedial and arcuate
nuclei of the hypothalamus and zona incerta. They are also found at lower levels in the periphery including
in the pituitary gland, adipose tissue and pancreas. MCH1 is a target for the orexigenic peptide leptin,
which supports a role for MCH receptors in the control of food intake and energy expenditure. The human
genes encoding MCH1 and MCH2 are localized to chromosomes 22q13.3 and 6q21 respectively. MCH2 is a
pseudogene in rodents.

Gene Wiki entry for MCHR2 (Melanin-concentrating hormone receptor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MCHR2 gene promoter:
         Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMCHR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MCHR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCHR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16   Ensembl cytogenetic band:  6q16.2   HGNC cytogenetic band: 6q16

MCHR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCHR2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M100367:  view genomic region     (about GC identifiers)

Start:
100,367,786 bp from pter      End:
100,442,114 bp from pter
Size:
74,329 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MCHR2_HUMAN, Q969V1 (See protein sequence)
Recommended Name: Melanin-concentrating hormone receptor 2  
Size: 340 amino acids; 38849 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B3KVW4 E1P5D7 Q5VTV7 Q6Q377 Q9BXA8

Explore the universe of human proteins at neXtProt for MCHR2: NX_Q969V1

Explore proteomics data for MCHR2 at MOPED 

MCHR2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

MCHR2 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001035269.1  NP_115892.2  

ENSEMBL proteins: 
 ENSP00000358214   ENSP00000403490   ENSP00000281806  
Reactome Protein details: Q969V1
Human Recombinant Protein Products for MCHR2: 
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Cloud-Clone Corp. Proteins for MCHR2 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IEA--

MCHR2 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
MCHR: GPCR / Class A : MCH receptors

IUPHAR Guide to PHARMACOLOGY protein family classification: MCH2 receptor 
Melanin-concentrating hormone receptors

4 InterPro protein domains:
 IPR008361 MCH_rcpt
 IPR017452 GPCR_Rhodpsn_7TM
 IPR008362 MCH2_receptor
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q969V1

ProtoNet protein and cluster: Q969V1

UniProtKB/Swiss-Prot: MCHR2_HUMAN, Q969V1
Similarity: Belongs to the G-protein coupled receptor 1 family


MCHR2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: MCHR2_HUMAN, Q969V1
Function: Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide
hydrolysis

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
     
MCHR2 for ontologies           About GeneDecksing


Animal Models:
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miRNA
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Inhib. RNA
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for MCHR2 About                                                                                                See pathways by source

SuperPathContained pathways About
1Class A/1 (Rhodopsin-like receptors)
Class A/1 (Rhodopsin-like receptors)0.71
G alpha (i) signalling events0.46
GPCR ligand binding0.71
Neuroactive ligand-receptor interaction0.37
Peptide ligand-binding receptors0.60
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
3G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPK0.90
G alpha (q) signalling events0.90
4GPCRs, Other
GPCRs, Other

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for MCHR2
    GPCRs, Other

5/9        Reactome Pathways for MCHR2 (see all 9)
    GPCR downstream signaling
Peptide ligand-binding receptors
Gastrin-CREB signalling pathway via PKC and MAPK
Signaling by GPCR
GPCR ligand binding


1         Kegg Pathway  (Kegg details for MCHR2):
    Neuroactive ligand-receptor interaction


MCHR2 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MCHR2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/246 Interacting proteins for MCHR2 (Q969V13 ENSP000002818064) via UniProtKB, MINT, STRING, and/or I2D (see all 246)
InteractantInteraction Details
GeneCardExternal ID(s)
PMCHP203823, ENSP000003322254I2D: score=1 STRING: ENSP00000332225
CXCR1ENSP000002956834STRING: ENSP00000295683
DRD2ENSP000003548594STRING: ENSP00000354859
DRD4ENSP000001761834STRING: ENSP00000176183
EDNRBENSP000003353114STRING: ENSP00000335311
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

MCHR2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MCHR2 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for MCHR2 available from Tocris Bioscience    About this table
CompoundAction CAS #
SNAP 94847 hydrochloridePotent and selective MCH1 antagonist[487051-12-7]
GW 803430MCH1 antagonist[515141-51-2]
ATC 0175 hydrochlorideMCH1 antagonist; also 5-HT2B antagonist and 5-HT1A partial agonist[510733-97-8]
MCH (human, mouse, rat) Potent endogenous MCH agonist[128315-56-0]
[Ala17]-MCH Potent, MCH receptor agonist [359784-84-2]

6 IUPHAR Ligands for MCHR2 (MCH2 receptor)    About this table 
LigandTypeActionAffinityPubmed IDs
[Phe13,Tyr19]MCH
AgonistFull agonist8.4 - 9.211459838 11404457
melanin-concentrating hormone
AgonistFull agonist8.2 - 9.211404457
Ac-hMCH-(6-16)-NH2
AgonistFull agonist8.4 - 8.812009900
[Ava9,10,Ava14,15]-Ac-hMCH6-16-NH2
AntagonistAntagonist7.312009900
MCH (salmon)
AgonistFull agonist6.2 - 7.111459838 11404457
ATC0065
AntagonistAntagonist5.8 - 5.915677346

1 Novoseek inferred chemical compound relationship for MCHR2 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
calcium 23.5 4 15476925 (1), 19397943 (1), 11404457 (1), 15340116 (1)

Search CenterWatch for drugs/clinical trials and news about MCHR2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MCHR2 gene (2 alternative transcripts): 
NM_001040179.1  NM_032503.2  

Unigene Cluster for MCHR2:

Melanin-concentrating hormone receptor 2
Hs.591342  [show with all ESTs]
Unigene Representative Sequence: BC038441
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000369212 ENST00000445970(uc003pqi.1) ENST00000281806(uc003pqh.1)

miRNA
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hsa-miR-640
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Inhib. RNA
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Additional mRNA sequence: 

AB058849.1 AB060151.1 AF347063.1 AF399937.1 AK123634.1 AY029596.1 AY562946.1 BC038441.1 
BC095515.1 

3 DOTS entries:

DT.95362394  DT.97827438  DT.91755813 

12 AceView cDNA sequences:

AB058849 BC038441 AK123634 BX279838 AY029596 AF399937 AY562946 CF147811 
AB060151 BI914562 AF347063 NM_032503 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MCHR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CAAATACAAT
MCHR2 Expression
About this image


See MCHR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MCHR2

SOURCE GeneReport for Unigene cluster: Hs.591342

UniProtKB/Swiss-Prot: MCHR2_HUMAN, Q969V1
Tissue specificity: Specifically expressed in the brain, with highest levels in cerebral cortex, hippocampus and
amygdala. No expression detected in the cerebellum, thalamus or hypothalamus

    SABiosciences Expression via Pathway-Focused PCR Array including MCHR2: 
          G Protein Coupled Receptors 384HT in human mouse rat

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MCHR2 gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia MCHR21 melanin-concentrating hormone receptor 2 90.42(n)
91.1(a)
  403562  NM_001003037.1  NP_001003037.1 
zebrafish
(Danio rerio)
Actinopterygii MCHR2 (1 of 2)6
MCHR2 (2 of 2)6
(see all 3)
melanin-concentrating hormone receptor 2
(see all 3)
67(a)
58(a)
(see all 3)
1 ↔ many
1 ↔ many
(see all 3)
16(35138222-35152276)
Zv9_NA491(43860-58507)
fruit fly
(Drosophila melanogaster)
Insecta star16
AlCR26
allatostatin C receptor 2
17(a)
15(a)
many ↔ many
many ↔ many
3L(18553358-18569426)
3L(18478237-18495657)
worm
(Caenorhabditis elegans)
Secernentea npr-246
npr-166
Protein NPR-16, isoform a
18(a)
14(a)
many ↔ many
many ↔ many
X(17483339-17486831)
X(3528812-3531826)


ENSEMBL Gene Tree for MCHR2 (if available)
TreeFam Gene Tree for MCHR2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MCHR2 gene
SSTR32  OPRL12  OPRK12  NPBWR12  OPRD12  KISS1R2  GALR12  SSTR42  
GALR22  SSTR52  SSTR12  GALR32  SSTR22  MCHR12  OPRM12  NPBWR22  
13 SIMAP similar genes for MCHR2 using alignment to 1 protein entry:     MCHR2_HUMAN:
MCHR1    GPR24    SSTR1    SSTR2    OPRK1    SSTR5
NPBWR1    OPRD1    OPRL1    OPRM1    NPBWR2    SSTR4
SSTR3

MCHR2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1556 SNPs in MCHR2 are shown (see all 1556)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1422594671,2
Cuntested1100403984(+) AAGTTC/TGGCAG 4 K E mis10--------
VAR_0266614
----see VAR_0266612 R K mis40--------
rs582476661,2
C,F--100367590(+) TCTTGT/CTTTTT 2 -- ds50015Minor allele frequency- C:0.20WA NA CSA 128
rs1999847361,2
--100367610(+) GTTTT-/GTTTTT 2 -- ds50010--------
rs1461358421,2
--100367658(+) GAGTGA/CAGTGG 2 -- ds50010--------
rs1399846991,2
--100367673(+) ATCTCA/GGCTCA 2 -- ds50010--------
rs1457015111,2
C--100367698(+) TCCTGA/GGTTCA 2 -- ds50010--------
rs1825875491,2
--100367792(+) GTAGAC/TAGGGT 2 -- ut310--------
rs1453706621,2
--100367816(+) CCAGAC/TTGGTC 2 -- ut310--------
rs1849734691,2
C--100367897(+) GCACCC/TGGCCA 2 -- ut310--------

HapMap Linkage Disequilibrium report for MCHR2 (100367786 - 100442114 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for MCHR2:    About this table     
Variant IDTypeSubtypePubMed ID
esv2659885CNV Deletion23128226
esv272904CNV Insertion20981092
esv269139CNV Insertion20981092
esv270014CNV Insertion20981092
esv1423203CNV Insertion17803354
esv2752086CNV Gain17911159
nsv886441CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 606111    OMIM disorders: --

8 diseases for MCHR2:    About MalaCards
hemolytic-uremic syndrome    shigellosis    mood disorder    diarrhea
obesity    schizophrenia    cerebritis    melanoma


MCHR2 for disorders           About GeneDecksing

1 Novoseek inferred disease relationship for MCHR2 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
obesity 21.1 5 17698913 (5)

Genetic Association Database (GAD): MCHR2
Human Genome Epidemiology (HuGE) Navigator: MCHR2 (7 documents)

Export disorders for MCHR2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MCHR2 gene, integrated from 9 sources (see all 40):
(articles sorted by number of sources associating them with MCHR2)
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  1. Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor. (PubMed id 11355873)1, 2, 3, 9 Mori M.... Fujino M. (2001)
  2. Molecular cloning and functional characterization of MCH2, a novel human MCH receptor. (PubMed id 11274220)1, 2, 3 Hill J....Muir A.I. (2001)
  3. Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity. (PubMed id 17698913)1, 4, 9 Ghoussaini M....Meyre D. (2007)
  4. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. (PubMed id 11404457)1, 2, 9 Sailer A.W.... Liu Q. (2001)
  5. Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, MCH-R2. (PubMed id 11459838)1, 2, 9 Wang S.... Hawes B.E. (2001)
  6. Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2. (PubMed id 15340116)1, 2, 9 Hawes B.E....Simon J.S. (2004)
  7. A systematic association mapping on chromosome 6q in bipolar affective disorder-evidence for the melanin-concentrating-hormone-recep tor-2 gene as a risk factor for bipolar affective disorder. (PubMed id 19927306)1, 4, 9 Abou Jamra R....Schumacher J. (2010)
  8. Thirty new loci for age at menarche identified by a m eta-analysis of genome-wide association studies. (PubMed id 21102462)1, 4 Elks C.E....Murray A. (2010)
  9. Two complex genotypes relevant to the kynurenine path way and melanotropin function show association with schizophrenia and bipolar d isorder. (PubMed id 19502010)1, 4 Miller C.L....Leonard S. (2009)
  10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84539 HGNC: 20867 AceView: GPR145 Ensembl:ENSG00000152034 euGenes: HUgn84539
ECgene: MCHR2 Kegg: 84539 H-InvDB: MCHR2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MCHR2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MCHR2 gene:
Search GeneIP for patents involving MCHR2

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