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Aliases for MCHR2 Gene

Aliases for MCHR2 Gene

  • Melanin Concentrating Hormone Receptor 2 2 3 5
  • G Protein-Coupled Receptor 145 2 3
  • G-Protein Coupled Receptor 145 3 4
  • MCH Receptor 2 3 4
  • GPR145 3 4
  • GPRv17 3 4
  • MCH-2R 3 4
  • MCH-R2 3 4
  • MCHR-2 3 4
  • MCH2R 3 4
  • MCH2 3 4
  • SLT 3 4
  • Melanin-Concentrating Hormone Receptor 2 2
  • Melanin-Concentrating Hormone 2 3
  • G Protein-Coupled Receptor Slt 3

External Ids for MCHR2 Gene

Previous HGNC Symbols for MCHR2 Gene

  • GPR145

Previous GeneCards Identifiers for MCHR2 Gene

  • GC06M100476
  • GC06M100367
  • GC06M097807

Summaries for MCHR2 Gene

GeneCards Summary for MCHR2 Gene

MCHR2 (Melanin Concentrating Hormone Receptor 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for MCHR2 Gene

  • Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.

Tocris Summary for MCHR2 Gene

  • Melanin-concentrating hormone (MCH) is a neuropeptide that is expressed in the central and peripheral nervous systems and plays an important role in the control of feeding behaviors and energy metabolism. MCH acts on two GPCRs: MCH1 (GPR24) and MCH2 (GPR145).

Gene Wiki entry for MCHR2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCHR2 Gene

Genomics for MCHR2 Gene

Regulatory Elements for MCHR2 Gene

Transcription factor binding sites by QIAGEN in the MCHR2 gene promoter:

Genomic Location for MCHR2 Gene

Chromosome:
6
Start:
99,919,910 bp from pter
End:
99,994,247 bp from pter
Size:
74,338 bases
Orientation:
Minus strand

Genomic View for MCHR2 Gene

Genes around MCHR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCHR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCHR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCHR2 Gene

Proteins for MCHR2 Gene

  • Protein details for MCHR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969V1-MCHR2_HUMAN
    Recommended name:
    Melanin-concentrating hormone receptor 2
    Protein Accession:
    Q969V1
    Secondary Accessions:
    • B3KVW4
    • E1P5D7
    • Q5VTV7
    • Q6Q377
    • Q9BXA8

    Protein attributes for MCHR2 Gene

    Size:
    340 amino acids
    Molecular mass:
    38849 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MCHR2 Gene

Proteomics data for MCHR2 Gene at MOPED

Post-translational modifications for MCHR2 Gene

  • Glycosylation at Asn 10 and Asn 17

Other Protein References for MCHR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MCHR2

No data available for DME Specific Peptides for MCHR2 Gene

Domains & Families for MCHR2 Gene

Gene Families for MCHR2 Gene

Protein Domains for MCHR2 Gene

Suggested Antigen Peptide Sequences for MCHR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969V1

UniProtKB/Swiss-Prot:

MCHR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with MCHR2: view

Function for MCHR2 Gene

Molecular function for MCHR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.

Gene Ontology (GO) - Molecular Function for MCHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0008528 G-protein coupled peptide receptor activity IBA --
genes like me logo Genes that share ontologies with MCHR2: view
genes like me logo Genes that share phenotypes with MCHR2: view

Animal Model Products

CRISPR Products

miRNA for MCHR2 Gene

miRTarBase miRNAs that target MCHR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCHR2 Gene

Localization for MCHR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCHR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCHR2 Gene COMPARTMENTS Subcellular localization image for MCHR2 gene
Compartment Confidence
plasma membrane 5
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for MCHR2 Gene

Pathways & Interactions for MCHR2 Gene

genes like me logo Genes that share pathways with MCHR2: view

Pathways by source for MCHR2 Gene

SIGNOR curated interactions for MCHR2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MCHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with MCHR2: view

Drugs & Compounds for MCHR2 Gene

(8) Drugs for MCHR2 Gene - From: Novoseek, IUPHAR, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[Ava<sup>9,10</sup>,Ava<sup>14,15</sup>]-Ac-hMCH<sub>6-16</sub>-NH2 Pharma Antagonist 0
[Phe<sup>13</sup>,Tyr<sup>19</sup>]MCH Pharma Full agonist, Agonist 0
Ac-hMCH-(6-16)-NH2 Pharma Full agonist, Agonist 0
ATC0065 Pharma Antagonist 0
MCH (salmon) Pharma Full agonist, Agonist 0

(5) Additional Compounds for MCHR2 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[Ala17]-MCH
359784-84-2
ATC 0065
510732-84-0
ATC 0175 hydrochloride
510733-97-8
MCH (human, mouse, rat)
128315-56-0
SNAP 94847 hydrochloride
487051-12-7

(5) Tocris Compounds for MCHR2 Gene

Compound Action Cas Number
[Ala17]-MCH Potent MCH receptor agonist 359784-84-2
ATC 0065 Potent and selective MCH1 antagonist 510732-84-0
ATC 0175 hydrochloride MCH1 antagonist; also 5-HT2B antagonist and 5-HT1A partial agonist 510733-97-8
MCH (human, mouse, rat) Potent endogenous MCH agonist 128315-56-0
SNAP 94847 hydrochloride Potent and selective MCH1 antagonist 487051-12-7
genes like me logo Genes that share compounds with MCHR2: view

Transcripts for MCHR2 Gene

mRNA/cDNA for MCHR2 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MCHR2 Gene

Melanin-concentrating hormone receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MCHR2 Gene

No ASD Table

Relevant External Links for MCHR2 Gene

GeneLoc Exon Structure for
MCHR2
ECgene alternative splicing isoforms for
MCHR2

Expression for MCHR2 Gene

mRNA expression in normal human tissues for MCHR2 Gene

mRNA differential expression in normal tissues according to GTEx for MCHR2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x17.7), Brain - Cortex (x12.9), and Brain - Anterior cingulate cortex (BA24) (x11.6).

SOURCE GeneReport for Unigene cluster for MCHR2 Gene Hs.591342

mRNA Expression by UniProt/SwissProt for MCHR2 Gene

Q969V1-MCHR2_HUMAN
Tissue specificity: Specifically expressed in the brain, with highest levels in cerebral cortex, hippocampus and amygdala. No expression detected in the cerebellum, thalamus or hypothalamus.
genes like me logo Genes that share expression patterns with MCHR2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MCHR2 Gene

Orthologs for MCHR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MCHR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MCHR2 35
  • 87.52 (n)
  • 82.34 (a)
MCHR2 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCHR2 35
  • 90.24 (n)
  • 90.83 (a)
MCHR2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MCHR2 35
  • 99.51 (n)
  • 99.41 (a)
MCHR2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCHR2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCHR2 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR151 36
  • 21 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 24 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mchr2 35
  • 70.99 (n)
  • 74.04 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100150764 35
  • 65.21 (n)
  • 66.78 (a)
mchr2 36
  • 33 (a)
OneToMany
MCHR2 (1 of 3) 36
  • 63 (a)
OneToMany
MCHR2 (3 of 3) 36
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta AlCR2 36
  • 17 (a)
ManyToMany
star1 36
  • 18 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea npr-24 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 16 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
Species with no ortholog for MCHR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MCHR2 Gene

ENSEMBL:
Gene Tree for MCHR2 (if available)
TreeFam:
Gene Tree for MCHR2 (if available)

Paralogs for MCHR2 Gene

(13) SIMAP similar genes for MCHR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MCHR2: view

Variants for MCHR2 Gene

Sequence variations from dbSNP and Humsavar for MCHR2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs147988902 - 99,947,966(+) TTTTC(C/T)TGGAT reference, missense
rs62434070 - 99,943,081(+) TGATC(C/T)GGATG reference, missense
rs2001456 -- 99,991,133(+) GGTGC(A/G)GGCAT intron-variant
rs2397435 -- 99,940,380(+) agtaa(C/T)ttttt intron-variant
rs2397662 -- 99,956,717(+) AAAAG(C/T)GTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCHR2 Gene

Variant ID Type Subtype PubMed ID
nsv886441 CNV Gain 21882294
esv2752086 CNV Gain 17911159
esv269139 CNV Insertion 20981092
esv2659885 CNV Deletion 23128226
esv272904 CNV Insertion 20981092
esv270014 CNV Insertion 20981092
esv1423203 CNV Insertion 17803354

Variation tolerance for MCHR2 Gene

Residual Variation Intolerance Score: 18.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCHR2 Gene

HapMap Linkage Disequilibrium report
MCHR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCHR2 Gene

Disorders for MCHR2 Gene

Relevant External Links for MCHR2

Genetic Association Database (GAD)
MCHR2
Human Genome Epidemiology (HuGE) Navigator
MCHR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCHR2

No disorders were found for MCHR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MCHR2 Gene

Publications for MCHR2 Gene

  1. Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor. (PMID: 11355873) Mori M. … Fujino M. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23 67
  2. A systematic association mapping on chromosome 6q in bipolar affective disorder--evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorder. (PMID: 19927306) Abou Jamra R. … Schumacher J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 23
  3. Melanin-concentrating hormone receptor 2 affects 3T3-L1 preadipocyte differentiation. (PMID: 19683862) Yang J. … Song F. (Mol. Cell. Endocrinol. 2009) 3 23
  4. Establishment of CHO cell line expressing human MCHR2 gene and research of its molecular characteristics. (PMID: 20099459) Yuan C. … Song F. (Indian J. Exp. Biol. 2009) 3 23
  5. Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity. (PMID: 17698913) Ghoussaini M. … Meyre D. (J. Clin. Endocrinol. Metab. 2007) 3 23

Products for MCHR2 Gene

Sources for MCHR2 Gene

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