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Aliases for MCHR1 Gene

Aliases for MCHR1 Gene

  • Melanin-Concentrating Hormone Receptor 1 2 3
  • GPR24 3 4 6
  • SLC1 3 4 6
  • Somatostatin Receptor-Like Protein 3 4
  • G Protein-Coupled Receptor 24 2 3
  • MCH Receptor 1 3 4
  • MCH-1R 3 4
  • MCH1R 3 4
  • SLC-1 3 4
  • G-Protein Coupled Receptor 24 4
  • MCH-R1 4
  • MCHR-1 4
  • MCHR 4

External Ids for MCHR1 Gene

Previous HGNC Symbols for MCHR1 Gene

  • GPR24

Previous GeneCards Identifiers for MCHR1 Gene

  • GC22P039405
  • GC22P041074
  • GC22P024040

Summaries for MCHR1 Gene

Entrez Gene Summary for MCHR1 Gene

  • The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008]

GeneCards Summary for MCHR1 Gene

MCHR1 (Melanin-Concentrating Hormone Receptor 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and hormone binding. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for MCHR1 Gene

  • Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.

Tocris Summary for MCHR1 Gene

  • Melanin-concentrating hormone (MCH) is a neuropeptide that is expressed in the central and peripheral nervous systems and plays an important role in the control of feeding behaviors and energy metabolism. MCH acts on two GPCRs; MCH1 (GPR24) and MCH2 (GPR145). MCH1 and MCH2 have very similar tissue distribution patterns and are expressed in many brain regions, particularly the ventromedial, dorsalmedial and arcuate nuclei of the hypothalamus and zona incerta. They are also found at lower levels in the periphery including in the pituitary gland, adipose tissue and pancreas. MCH1 is a target for the orexigenic peptide leptin, which supports a role for MCH receptors in the control of food intake and energy expenditure. The human genes encoding MCH1 and MCH2 are localized to chromosomes 22q13.3 and 6q21 respectively. MCH2 is a pseudogene in rodents.

Gene Wiki entry for MCHR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCHR1 Gene

Genomics for MCHR1 Gene

Regulatory Elements for MCHR1 Gene

Genomic Location for MCHR1 Gene

Start:
40,678,750 bp from pter
End:
40,682,814 bp from pter
Size:
4,065 bases
Orientation:
Plus strand

Genomic View for MCHR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCHR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCHR1 Gene

Proteins for MCHR1 Gene

  • Protein details for MCHR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99705-MCHR1_HUMAN
    Recommended name:
    Melanin-concentrating hormone receptor 1
    Protein Accession:
    Q99705
    Secondary Accessions:
    • B2RBX6
    • Q5R3J1
    • Q96S47
    • Q9BV08

    Protein attributes for MCHR1 Gene

    Size:
    422 amino acids
    Molecular mass:
    45963 Da
    Quaternary structure:
    • Interacts with NCDN.
    SequenceCaution:
    • Sequence=AAC14587.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for MCHR1 Gene

Proteomics data for MCHR1 Gene at MOPED

Post-translational modifications for MCHR1 Gene

  • Glycosylation at Asn82, Asn85, and Asn92
  • Modification sites at PhosphoSitePlus

Other Protein References for MCHR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MCHR1 Gene

Domains for MCHR1 Gene

Gene Families for MCHR1 Gene

HGNC:
  • MCHR :GPCR / Class A : MCH receptors
IUPHAR :

Suggested Antigen Peptide Sequences for MCHR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99705

UniProtKB/Swiss-Prot:

MCHR1_HUMAN :
  • Q99705
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with MCHR1: view

Function for MCHR1 Gene

Molecular function for MCHR1 Gene

UniProtKB/Swiss-Prot Function: Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.

Gene Ontology (GO) - Molecular Function for MCHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 10421367
GO:0008022 protein C-terminus binding IEA --
GO:0008188 neuropeptide receptor activity TAS 10860944
GO:0030273 melanin-concentrating hormone receptor activity IEA --
GO:0042562 hormone binding IEA --
genes like me logo Genes that share ontologies with MCHR1: view
genes like me logo Genes that share phenotypes with MCHR1: view

Animal Models for MCHR1 Gene

MGI Knock Outs for MCHR1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for MCHR1 Gene

Localization for MCHR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCHR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCHR1 Gene COMPARTMENTS Subcellular localization image for MCHR1 gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MCHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10421367
GO:0016021 integral component of membrane --
GO:0031513 nonmotile primary cilium ISS --
GO:0060170 ciliary membrane IEA --
genes like me logo Genes that share ontologies with MCHR1: view

Pathways for MCHR1 Gene

genes like me logo Genes that share pathways with MCHR1: view

Pathways by source for MCHR1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MCHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 10421367
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway TAS 10421368
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS 10421367
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
genes like me logo Genes that share ontologies with MCHR1: view

Compounds for MCHR1 Gene

(5) Tocris Compounds for MCHR1 Gene

Compound Action Cas Number
MCH (human, mouse, rat) Potent endogenous MCH agonist [128315-56-0]
ATC 0175 hydrochloride MCH1 antagonist; also 5-HT2B antagonist and 5-HT1A partial agonist [510733-97-8]
GW 803430 MCH1 antagonist [515141-51-2]
SNAP 94847 hydrochloride Potent and selective MCH1 antagonist [487051-12-7]
TC-MCH 7c Selective melanin-concentrating hormone receptor 1 (MCH1R) antagonist [864756-35-4]

(32) IUPHAR Ligand for MCHR1 Gene

Ligand Type Action Affinity Pubmed IDs
[125I]MCH (human, mouse, rat) Agonist Full agonist 10.8
S36057 Agonist Full agonist 10.4
S38151 Antagonist Antagonist 10
MCH6-17 Agonist Full agonist 9.8
compound 2 [PMID:11375253] Agonist Full agonist 9.7
[125I]S36057 Antagonist Antagonist 9.5
[125I](3-iodo-Tyr13)-MCH Antagonist Antagonist 9.4
compound 17 [PMID:17125263] Antagonist Antagonist 9.4
GW803430 Antagonist Antagonist 9.3
melanin-concentrating hormone Agonist Full agonist 9.2
[Phe13,Tyr19]MCH Agonist Full agonist 9.2
[125I][Phe13,Tyr19]MCH Agonist Full agonist 9.2
SNAP-7941 Antagonist Antagonist 9.2
tetralin_urea analogue (7o) Antagonist Antagonist 9.1
C3 Agonist Full agonist 8.9
Ac-hMCH-(6-16)-NH2 Agonist Full agonist 8.8
7-fluorochromone-2-carboxamide Antagonist Antagonist 8.5
p-guanidinobenzoyl-MCH-(7-17) Agonist Full agonist 8.4
T-226296 Antagonist Antagonist 8.3
S36541 Antagonist Antagonist 8.3
TPI 1361-17 Antagonist Antagonist 8.2
ATC0175 Antagonist Antagonist 8.1
S36539 Antagonist Antagonist 8
S36540 Antagonist Antagonist 7.8
[3H]SNAP-7941 Antagonist Antagonist 7.8
SB-568849 Antagonist Antagonist 7.7
S36077 Agonist Full agonist 7.4
[Ava9,10,Ava14,15]-Ac-hMCH6-16-NH2 Antagonist Antagonist 7.3
MCH (salmon) Agonist Full agonist 7.1
variant MCH Agonist Full agonist 6.6
ATC0065 Antagonist Antagonist 5.9
[3H]MCH (human, mouse, rat) Agonist Full agonist

(6) Novoseek inferred chemical compound relationships for MCHR1 Gene

Compound -log(P) Hits PubMed IDs
aminoquinoline 79.1 2
lead 45.1 2
calcium 7.9 5
haloperidol 5.41 2
forskolin 0.777 1
genes like me logo Genes that share compounds with MCHR1: view

Transcripts for MCHR1 Gene

Unigene Clusters for MCHR1 Gene

Melanin-concentrating hormone receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MCHR1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCHR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: -
SP3: - -
SP4:

Relevant External Links for MCHR1 Gene

GeneLoc Exon Structure for
MCHR1
ECgene alternative splicing isoforms for
MCHR1

Expression for MCHR1 Gene

mRNA expression in normal human tissues for MCHR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MCHR1 Gene

This gene is overexpressed in Brain - Cortex (7.7), Brain - Anterior cingulate cortex (BA24) (6.9), Brain - Frontal Cortex (BA9) (6.7), and Brain - Hypothalamus (6.1).

SOURCE GeneReport for Unigene cluster for MCHR1 Gene Hs.248122

mRNA Expression by UniProt/SwissProt for MCHR1 Gene

Q99705-MCHR1_HUMAN
Tissue specificity: Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart
genes like me logo Genes that share expressions with MCHR1: view

In Situ Assay Products

No data available for Protein expression for MCHR1 Gene

Orthologs for MCHR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MCHR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCHR1 35
  • 100 (n)
  • 100 (a)
MCHR1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MCHR1 35
  • 92.33 (n)
  • 97.44 (a)
MCHR1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCHR1 35
  • 91.88 (n)
  • 97.17 (a)
MCHR1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mchr1 35
  • 88.95 (n)
  • 96.03 (a)
Mchr1 16
Mchr1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCHR1 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCHR1 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mchr1 35
  • 90.18 (n)
  • 96.03 (a)
chicken
(Gallus gallus)
Aves LOC100859572 35
  • 66.56 (n)
  • 59.41 (a)
MCHR1 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCHR1 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mchr1.2 35
  • 64.53 (n)
  • 67.07 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
mchr1a 35
  • 60.84 (n)
  • 56.51 (a)
mchr1a 36
  • 51 (a)
OneToMany
mchr1b 36
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta AlCR2 36
  • 18 (a)
ManyToMany
star1 36
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea npr-24 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 15 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
Species with no ortholog for MCHR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MCHR1 Gene

ENSEMBL:
Gene Tree for MCHR1 (if available)
TreeFam:
Gene Tree for MCHR1 (if available)

Paralogs for MCHR1 Gene

Selected SIMAP similar genes for MCHR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MCHR1: view

Variants for MCHR1 Gene

Sequence variations from dbSNP and Humsavar for MCHR1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs133067 -- 40,678,164(+) ttgca(C/T)tggcg upstream-variant-2KB
rs133068 -- 40,678,403(+) tcccc(C/G)caact upstream-variant-2KB
rs133069 -- 40,678,458(+) ccccc(A/C)ctttt upstream-variant-2KB
rs133070 -- 40,678,769(+) AAAGA(A/G)TCCCA upstream-variant-2KB
rs133071 -- 40,679,228(+) CGATC(C/T)TCACG utr-variant-5-prime, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MCHR1 Gene

Variant ID Type Subtype PubMed ID
nsv834205 CNV Gain+Loss 17160897
nsv915111 CNV Loss 21882294
nsv915112 CNV Loss 21882294

Relevant External Links for MCHR1 Gene

HapMap Linkage Disequilibrium report
MCHR1
Human Gene Mutation Database (HGMD)
MCHR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCHR1 Gene

Disorders for MCHR1 Gene

(2) University of Copenhagen DISEASES for MCHR1 Gene

(3) Novoseek inferred disease relationships for MCHR1 Gene

Disease -log(P) Hits PubMed IDs
obesity 56 20
vitiligo 46.8 5
melanoma 0 2

Relevant External Links for MCHR1

Genetic Association Database (GAD)
MCHR1
Human Genome Epidemiology (HuGE) Navigator
MCHR1
genes like me logo Genes that share disorders with MCHR1: view

No data available for UniProtKB/Swiss-Prot for MCHR1 Gene

Publications for MCHR1 Gene

  1. Characterization of a human gene related to genes encoding somatostatin receptors. (PMID: 8977118) Kolakowski L.F. Jr. … O'Dowd B.F. (FEBS Lett. 1996) 3 4 23
  2. Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2. (PMID: 15340116) Hawes B.E. … Simon J.S. (Obes. Res. 2004) 3 4 23
  3. Mutation analysis of the MCHR1 gene in human obesity. (PMID: 15941924) Wermter A.-K. … Hebebrand J. (Eur. J. Endocrinol. 2005) 3 4 23
  4. Association of melanin-concentrating hormone receptor 1 5' polymorphism with early-onset extreme obesity. (PMID: 16186414) Bell C.G. … Walley A.J. (Diabetes 2005) 3 23 48
  5. Association analyses suggest GPR24 as a shared susceptibility gene for bipolar affective disorder and schizophrenia. (PMID: 16741940) Severinsen J.E. … rglum A.D. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006) 3 23 48

Products for MCHR1 Gene

Sources for MCHR1 Gene

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