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Aliases for MCHR1 Gene

Aliases for MCHR1 Gene

  • Melanin Concentrating Hormone Receptor 1 2 3 5
  • Melanin-Concentrating Hormone Receptor 1 2 3
  • Somatostatin Receptor-Like Protein 3 4
  • G Protein-Coupled Receptor 24 2 3
  • MCH Receptor 1 3 4
  • MCH-1R 3 4
  • GPR24 3 4
  • MCH1R 3 4
  • SLC-1 3 4
  • SLC1 3 4
  • G-Protein Coupled Receptor 24 4
  • MCH-R1 4
  • MCHR-1 4
  • MCHR 4

External Ids for MCHR1 Gene

Previous HGNC Symbols for MCHR1 Gene

  • GPR24

Previous GeneCards Identifiers for MCHR1 Gene

  • GC22P039405
  • GC22P041074
  • GC22P024040

Summaries for MCHR1 Gene

Entrez Gene Summary for MCHR1 Gene

  • The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008]

GeneCards Summary for MCHR1 Gene

MCHR1 (Melanin Concentrating Hormone Receptor 1) is a Protein Coding gene. Diseases associated with MCHR1 include Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1 and Obesity. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and hormone binding. An important paralog of this gene is MCHR2.

UniProtKB/Swiss-Prot for MCHR1 Gene

  • Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.

Tocris Summary for MCHR1 Gene

  • Melanin-concentrating hormone (MCH) is a neuropeptide that is expressed in the central and peripheral nervous systems and plays an important role in the control of feeding behaviors and energy metabolism. MCH acts on two GPCRs: MCH1 (GPR24) and MCH2 (GPR145).

Gene Wiki entry for MCHR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCHR1 Gene

Genomics for MCHR1 Gene

Regulatory Elements for MCHR1 Gene

Enhancers for MCHR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F040650 1.8 FANTOM5 Ensembl ENCODE 12.8 -25.4 -25418 4.9 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 FOS ZNF263 XPNPEP3 GAPDHP37 MCHR1 LOC101927257 SLC25A17 ST13 PMM1 ADSL MKL1 RPL4P6
GH22F040644 1.2 Ensembl ENCODE 12.3 -33.1 -33106 3.1 PKNOX1 MLX ARID4B SLC30A9 ZNF121 ZNF143 SP5 REST KAT8 SSRP1 XPNPEP3 GAPDHP37 MCHR1 LOC101927257 ST13 ADSL LOC105373038 MKL1
GH22F040588 0.9 ENCODE 11 -89.6 -89637 1.5 ELF3 MLX ZFP64 ARID4B DMAP1 ZNF48 ZSCAN9 RAD21 RARA MIXL1 MKL1 SGSM3 ENSG00000229999 LOC101927257 MCHR1 GAPDHP37 RPL4P6
GH22F040726 1.2 Ensembl ENCODE 5.8 +51.9 51891 8.1 PKNOX1 FEZF1 RAD21 ZNF121 ZNF366 KLF7 ZNF548 FOS ZEB2 PPARG EP300 PHF5A ENSG00000272834 ENSG00000232754 XRCC6 ENSG00000227413 XPNPEP3 MCHR1 GC22M040968 LOC100313968
GH22F040647 0.4 ENCODE 12.3 -30.7 -30655 1.5 CEBPB XPNPEP3 GAPDHP37 MCHR1 LOC101927257 ST13 LOC105373038 MKL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MCHR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MCHR1 Gene

Chromosome:
22
Start:
40,678,750 bp from pter
End:
40,682,814 bp from pter
Size:
4,065 bases
Orientation:
Plus strand

Genomic View for MCHR1 Gene

Genes around MCHR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCHR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCHR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCHR1 Gene

Proteins for MCHR1 Gene

  • Protein details for MCHR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99705-MCHR1_HUMAN
    Recommended name:
    Melanin-concentrating hormone receptor 1
    Protein Accession:
    Q99705
    Secondary Accessions:
    • B2RBX6
    • Q5R3J1
    • Q96S47
    • Q9BV08

    Protein attributes for MCHR1 Gene

    Size:
    422 amino acids
    Molecular mass:
    45963 Da
    Quaternary structure:
    • Interacts with NCDN.
    SequenceCaution:
    • Sequence=AAC14587.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for MCHR1 Gene

Post-translational modifications for MCHR1 Gene

  • Glycosylation at Asn 82, Asn 85, and Asn 92
  • Modification sites at PhosphoSitePlus

Other Protein References for MCHR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for MCHR1

No data available for DME Specific Peptides for MCHR1 Gene

Domains & Families for MCHR1 Gene

Gene Families for MCHR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q99705

UniProtKB/Swiss-Prot:

MCHR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with MCHR1: view

Function for MCHR1 Gene

Molecular function for MCHR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.

Gene Ontology (GO) - Molecular Function for MCHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA,TAS 10421367
GO:0008188 neuropeptide receptor activity TAS 10860944
GO:0030273 melanin-concentrating hormone receptor activity IEA,IBA --
genes like me logo Genes that share ontologies with MCHR1: view
genes like me logo Genes that share phenotypes with MCHR1: view

Animal Models for MCHR1 Gene

MGI Knock Outs for MCHR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for MCHR1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MCHR1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MCHR1 Gene

Localization for MCHR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCHR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCHR1 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MCHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10421367
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0097730 non-motile cilium ISS --
genes like me logo Genes that share ontologies with MCHR1: view

Pathways & Interactions for MCHR1 Gene

genes like me logo Genes that share pathways with MCHR1: view

SIGNOR curated interactions for MCHR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MCHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 10421367
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS 10421368
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS 10421367
genes like me logo Genes that share ontologies with MCHR1: view

Drugs & Compounds for MCHR1 Gene

(50) Drugs for MCHR1 Gene - From: ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATC 0065 Pharma MCH1 antagonist,potent and selective, Potent and selective MCH1 antagonist 0
GW 803430 Pharma MCH1 antagonist 0
MCH (human, mouse, rat) Pharma Potent endogenous MCH agonist 0
SNAP 94847 hydrochloride Pharma Potent and selective MCH1 antagonist 0
TC-MCH 7c Pharma Selective melanin-concentrating hormone receptor 1 (MCH1R) antagonist 0

(2) Additional Compounds for MCHR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for MCHR1 Gene

Compound Action Cas Number
ATC 0065 Potent and selective MCH1 antagonist 510732-84-0
GW 803430 MCH1 antagonist 515141-51-2
MCH (human, mouse, rat) Potent endogenous MCH agonist 128315-56-0
SNAP 94847 hydrochloride Potent and selective MCH1 antagonist 487051-12-7
TC-MCH 7c Selective melanin-concentrating hormone receptor 1 (MCH1R) antagonist 864756-35-4

(7) ApexBio Compounds for MCHR1 Gene

Compound Action Cas Number
[Ala17]-MCH 359784-84-2
ATC 0065 MCH1 antagonist,potent and selective 510732-84-0
ATC 0175 hydrochloride MCH1 antagonist,potent and selective 510733-97-8
GW 803430 515141-51-2
MCH (human, mouse, rat) 128315-56-0
SNAP 94847 hydrochloride 487051-12-7
TC-MCH 7c 864756-35-4
genes like me logo Genes that share compounds with MCHR1: view

Transcripts for MCHR1 Gene

Unigene Clusters for MCHR1 Gene

Melanin-concentrating hormone receptor 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MCHR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCHR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: -
SP3: - -
SP4:

Relevant External Links for MCHR1 Gene

GeneLoc Exon Structure for
MCHR1
ECgene alternative splicing isoforms for
MCHR1

Expression for MCHR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MCHR1 Gene

mRNA differential expression in normal tissues according to GTEx for MCHR1 Gene

This gene is overexpressed in Brain - Cortex (x7.7), Brain - Anterior cingulate cortex (BA24) (x6.9), Brain - Frontal Cortex (BA9) (x6.7), and Brain - Hypothalamus (x6.1).

NURSA nuclear receptor signaling pathways regulating expression of MCHR1 Gene:

MCHR1

SOURCE GeneReport for Unigene cluster for MCHR1 Gene:

Hs.248122

mRNA Expression by UniProt/SwissProt for MCHR1 Gene:

Q99705-MCHR1_HUMAN
Tissue specificity: Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.
genes like me logo Genes that share expression patterns with MCHR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MCHR1 Gene

Orthologs for MCHR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MCHR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCHR1 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia MCHR1 34 35
  • 92.33 (n)
dog
(Canis familiaris)
Mammalia MCHR1 34 35
  • 91.88 (n)
rat
(Rattus norvegicus)
Mammalia Mchr1 34
  • 90.18 (n)
mouse
(Mus musculus)
Mammalia Mchr1 34 16 35
  • 88.95 (n)
oppossum
(Monodelphis domestica)
Mammalia MCHR1 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCHR1 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859572 34
  • 66.56 (n)
MCHR1 35
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCHR1 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mchr1.2 34
  • 64.53 (n)
zebrafish
(Danio rerio)
Actinopterygii mchr1a 34 35
  • 60.84 (n)
mchr1b 35
  • 54 (a)
OneToMany
-- 34
fruit fly
(Drosophila melanogaster)
Insecta star1 35
  • 21 (a)
ManyToMany
AlCR2 35
  • 18 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea npr-24 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
-- 35
  • 15 (a)
ManyToMany
Species where no ortholog for MCHR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MCHR1 Gene

ENSEMBL:
Gene Tree for MCHR1 (if available)
TreeFam:
Gene Tree for MCHR1 (if available)

Paralogs for MCHR1 Gene

(13) SIMAP similar genes for MCHR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MCHR1: view

Variants for MCHR1 Gene

Sequence variations from dbSNP and Humsavar for MCHR1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs111800111 -- 40,682,714(+) CTGCA(C/T)GTGCA utr-variant-3-prime
rs112051789 -- 40,678,468(+) TTTTC(-/T)TTTTT upstream-variant-2KB
rs112216473 -- 40,680,591(+) ACACA(-/AT/CA)TACAC intron-variant
rs112405400 -- 40,679,528(+) GGAAG(A/T)CCCCC reference, missense
rs112670787 -- 40,680,264(+) GGATT(-/C)CAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCHR1 Gene

Variant ID Type Subtype PubMed ID
esv3568413 CNV loss 25503493
nsv1062438 CNV gain 25217958
nsv1160763 CNV duplication 26073780
nsv589047 CNV loss 21841781
nsv834205 CNV gain+loss 17160897
nsv955161 CNV deletion 24416366

Variation tolerance for MCHR1 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.59; 56.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCHR1 Gene

Human Gene Mutation Database (HGMD)
MCHR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCHR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCHR1 Gene

Disorders for MCHR1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MCHR1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
vitiligo-associated multiple autoimmune disease susceptibility 1
  • vitiligo
obesity
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards
Search MCHR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MCHR1

Genetic Association Database (GAD)
MCHR1
Human Genome Epidemiology (HuGE) Navigator
MCHR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCHR1
genes like me logo Genes that share disorders with MCHR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MCHR1 Gene

Publications for MCHR1 Gene

  1. Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans. (PMID: 18198296) Rutanen J. … Laakso M. (Obesity (Silver Spring) 2007) 3 22 46 64
  2. Association analyses suggest GPR24 as a shared susceptibility gene for bipolar affective disorder and schizophrenia. (PMID: 16741940) Severinsen J.E. … rglum A.D. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006) 3 22 46 64
  3. Mutation analysis of the MCHR1 gene in human obesity. (PMID: 15941924) Wermter A.-K. … Hebebrand J. (Eur. J. Endocrinol. 2005) 3 4 22 64
  4. Association of melanin-concentrating hormone receptor 1 5' polymorphism with early-onset extreme obesity. (PMID: 16186414) Bell C.G. … Walley A.J. (Diabetes 2005) 3 22 46 64
  5. Melanin-concentrating hormone receptor mutations and human obesity: functional analysis. (PMID: 15166293) Gibson W.T. … Farooqi I.S. (Obes. Res. 2004) 3 4 46 64

Products for MCHR1 Gene

Sources for MCHR1 Gene

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