Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MCF2L2 Gene

protein-coding GIFtS: 53
GCID: GC03M182895

MCF.2 cell line derived transforming sequence-like 2

Explore 4 diseases affiliated with
MCF2L2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
MCF.2 Cell Line Derived Transforming Sequence-Like 2¹ ²		MCF2-Transforming Sequence-Like Protein 2² ³
ARHGEF22¹ ²		Probable Guanine Nucleotide Exchange Factor MCF2L2²
KIAA0861¹ ³		DRG³
Dbs-Related Rho Family Guanine Nucleotide Exchange Factor² ³

External Ids:	HGNC: 30319¹	Entrez Gene: 23101²	Ensembl: ENSG00000053524⁷	UniProtKB: Q86YR7³

Export aliases for MCF2L2 gene to outside databases

Previous GC identifers: GC03M184378 GC03M180301

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MF2L2_HUMAN, Q86YR7

Function: Probably functions as a guanine nucleotide exchange factor (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MCF2L2 gene promoter:
En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MCF2L2 promoter sequence

Search SABiosciences Chromatin IP Primers for MCF2L2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCF2L2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27.1 Ensembl cytogenetic band: 3q27.1 HGNC cytogenetic band: 3q27

MCF2L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCF2L2 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M182895: view genomic region (about GC identifiers)

Start:	182,895,831 bp from pter	End:	183,146,566 bp from pter
Size:	250,736 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MF2L2_HUMAN, Q86YR7 (See protein sequence)

Recommended Name: Probable guanine nucleotide exchange factor MCF2L2

Size: 1114 amino acids; 126993 Da

Sequence caution: Sequence=AAO19651.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: O94942 Q6P2B8 Q6ZVJ5 Q8N318

Alternative splicing: 4 isoforms: Q86YR7-1 Q86YR7-2 Q86YR7-3 Q86YR7-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MCF2L2: NX_Q86YR7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86YR7

MCF2L2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055893.2

ENSEMBL proteins:

ENSP00000328118 ENSP00000420070 ENSP00000388190 ENSP00000414131 ENSP00000417345

Human Recombinant Protein Products for MCF2L2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for MCF2L2
	GenScript Custom Purified and Recombinant Proteins Services for MCF2L2
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MCF2L2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--

MCF2L2 for ontologies About GeneDecksing

MCF2L2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for MCF2L2
	GenScript Custom Superior Antibodies Services for MCF2L2
	Novus Biologicals MCF2L2 Antibodies
	Abcam antibodies for MCF2L2
	Uscn Antibodies for MCF2L2
	ThermoFisher Antibody for MCF2L2

Assay Products for MCF2L2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MCF2L2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MCF2L2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MCF2L2 for domains About GeneDecksing

5 InterPro domains/families:

IPR000219 DH-domain

IPR001849 Pleckstrin_homology

IPR001251 CRAL-TRIO_dom

IPR011993 PH_like_dom

IPR018159 Spectrin/alpha-actinin

Graphical View of Domain Structure for InterPro Entry Q86YR7

ProtoNet protein and cluster: Q86YR7

2 Blocks protein families:

IPB000219 DH domain

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: MF2L2_HUMAN, Q86YR7

Similarity: Belongs to the MCF2 family

Similarity: Contains 1 CRAL-TRIO domain

Similarity: Contains 1 DH (DBL-homology) domain

Similarity: Contains 1 PH domain

Similarity: Contains 1 spectrin repeat

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MF2L2_HUMAN, Q86YR7

Function: Probably functions as a guanine nucleotide exchange factor (By similarity)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005089	Rho guanyl-nucleotide exchange factor activity	IEA	--
GO:0005543	phospholipid binding	IEA	--

MCF2L2 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for MCF2L2:

Cell division defect

Increased G2M DNA content

Increased number of mitotic ce

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MCF2L2

miRNA Products:		OriGene 3'-UTR Clone: MCF2L2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCF2L2
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate MCF2L2:
		hsa-miR-3163 hsa-miR-3132 hsa-miR-219-5p hsa-miR-548c-3p hsa-miR-508-3p
		SwitchGear 3'UTR luciferase reporter plasmid: MCF2L2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCF2L2 OriGene shRNA RFP: MCF2L2 OriGene siRNA: MCF2L2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MCF2L2
		Sirion Biotech Custom design and validation of potent shRNA sequences against MCF2L2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MCF2L2
			Sirion Biotech Customized adenovirus for overexpression of MCF2L2 Sirion Biotech Customized adenovirus for potent knockdown of MCF2L2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCF2L2 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCF2L2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MCF2L2 (NM_015078)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCF2L2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCF2L2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MCF2L2
		Search LifeMap BioReagents cell lines for MCF2L2
		Sirion Biotech Customized stable knockdown cell line services for MCF2L2 Sirion Biotech Customized inducible knockdown cell line services for MCF2L2 Sirion Biotech Customized stable overexpressing cell line services for MCF2L2 Sirion Biotech Customized inducible overexpressing cell line services for MCF2L2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCF2L2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MCF2L2

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for MCF2L2 (Q86YR7³ ENSP00000328118⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SIRT1	Q96EB6³, ENSP00000212015⁴	I2D: score=2 STRING: ENSP00000212015
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207
MEGF10	Q96KG7³, ENSP00000274473⁴	I2D: score=2 STRING: ENSP00000274473
RASL10B	ENSP00000268864⁴	STRING: ENSP00000268864
RAB19	ENSP00000275874⁴	STRING: ENSP00000275874

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0035023	regulation of Rho protein signal transduction	IEA	--

MCF2L2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MCF2L2

3 HMDB Compounds for MCF2L2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about MCF2L2 / MF2L2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MCF2L2 gene:

NM_015078.2

Unigene Cluster for MCF2L2:

MCF.2 cell line derived transforming sequence-like 2

Hs.208267 [show with all ESTs]

Unigene Representative Sequence: BX649003

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000328913(uc003fli.1) ENST00000473233 ENST00000478652 ENST00000464626

ENST00000468976 ENST00000488149(uc011bqr.1) ENST00000447025(uc003flj.1 uc011bqs.1)

ENST00000414362 ENST00000475664 ENST00000459750(uc003flp.1) ENST00000492331

ENST00000482017 ENST00000461074

miRNA Products:		OriGene 3'-UTR Clone: MCF2L2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCF2L2
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate MCF2L2:
		hsa-miR-3163 hsa-miR-3132 hsa-miR-219-5p hsa-miR-548c-3p hsa-miR-508-3p
		SwitchGear 3'UTR luciferase reporter plasmid: MCF2L2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCF2L2 OriGene shRNA RFP: MCF2L2 OriGene siRNA: MCF2L2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MCF2L2
		Sirion Biotech Custom design and validation of potent shRNA sequences against MCF2L2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCF2L2 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCF2L2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MCF2L2 (NM_015078)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCF2L2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCF2L2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MCF2L2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat MCF2L2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCF2L2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCF2L2

Additional cDNA sequence:

AB020668.1 AK124500.1 AK301698.1 AK310962.1 AY172737.1 BC029074.2 BC064632.1 BX647790.1

BX648525.1 BX649003.1

15 DOTS entries:

DT.91907482 DT.97837559 DT.311018 DT.102842877 DT.101978686 DT.86849491 DT.99936716 DT.120868409

DT.92028182 DT.120868411 DT.75129021 DT.92022931 DT.95162130 DT.97792580 DT.91855366

24/56 AceView cDNA sequences (see all 56):

CD367113 CA848316 BX642438 NM_015078 AK124500 BU685704 AI074993 BX487485

AI871372 CA848607 BU683997 BG184963 BC064632 BX109053 AB020668 BC029074

BX649003 AA325939 AI370362 AY172737 BM929566 BX642437 BU685601 BG192266

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MCF2L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

MCF2L2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MCF2L2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MCF2L2

SOURCE GeneReport for Unigene cluster: Hs.208267

UniProtKB/Swiss-Prot: MF2L2_HUMAN, Q86YR7

Tissue specificity: Significantly expressed in brain and modestly in pancreas, brain and testis

SABiosciences Custom PCR Arrays for MCF2L2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MCF2L2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat MCF2L2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCF2L2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCF2L2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCF2L2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MCF2L2 gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MCF2L2¹	MCF.2 cell line derived transforming sequence-like more	69.19(n) 66.27(a)		424959 XM_422768.3 XP_422768.3
lizard (Anolis carolinensis)	Reptilia	MCF2L2⁶	--	48(a)	1 ↔ 1	3(15942-151520)
zebrafish (Danio rerio)	Actinopterygii	CT990625.1⁶	--	47(a)	1 ↔ 1	11(10533584-10722703)
fruit fly (Drosophila melanogaster)	Insecta	CG30440⁶	--	15(a)	possible ortholog	2R(1355819-1383341)
worm (Caenorhabditis elegans)	Secernentea	cgef-1⁶	CDC-42 Guanine nucleotide Exchange Factor family m...	17(a)	1 → many	X(2785593-2799235)

ENSEMBL Gene Tree for MCF2L2 (if available)
TreeFam Gene Tree for MCF2L2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MCF2L2 gene

KALRN² ARHGEF25² PLEKHG4B² TRIO² MCF2L² KIAA1755² PLEKHG4² MCF2²

ARHGEF40²

5 SIMAP similar genes for MCF2L2 using alignment to 2 protein entries: MF2L2_HUMAN (see all proteins):

MCF2L TRIO MCF2 tgat SESTD1

MCF2L2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for MCF2L2
PGOHUM00000238296

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189758219^1,2		--	182895340(+)	`GGTGCC/TTGTAA`	1	--	ds500¹		0	--	--	--	--
rs181176221^1,2		--	182895362(+)	`TGGGAA/GGCTGA`	1	--	ds500¹		0	--	--	--	--
rs138700866^1,2		--	182895390(+)	`AACCCA/GGGAGG`	1	--	ds500¹		0	--	--	--	--
rs112819183^1,2	C	--	182895397(+)	`GAGGCG/AGAGGT`	1	--	ds500¹		1		WA	2
rs150802453^1,2		--	182895457(+)	`CAAAAC/TTCCAT`	1	--	ds500¹		0	--	--	--	--
rs186534107^1,2		--	182895477(+)	`AAAAAA/GAAAGA`	1	--	ds500¹		0	--	--	--	--
rs199957865^1,2		--	182895550(+)	`AAAAG-/AAAT AACTG`	1	--	ds500¹		0	--	--	--	--
rs201351292^1,2		--	182895556(+)	`AATAA-/CTGAGAA`	1	--	ds500¹		0	--	--	--	--
rs35316957^1,2	C	--	182895557(+)	`ATAAC-/TGAGAAT`	1	--	ds500¹		1		NA	2
rs73058058^1,2	C	--	182895617(+)	`AAAAAT/ATCAGA`	1	--	ds500¹		1		WA	2

HapMap Linkage Disequilibrium report for MCF2L2 (182895831 - 183145831 bp, first 250kb of MCF2L2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for MCF2L2
1 CNV: 51025
3 Indels: 68511 60445 98551
Human Gene Mutation Database (HGMD): MCF2L2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MCF2L2

DNA2.0 Custom Variant and Variant Library Synthesis for MCF2L2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MCF2L2 for disorders About GeneDecksing

UniProtKB/Swiss-Prot: MF2L2_HUMAN, Q86YR7

Genetic variation in MCF2L2 may be associated with susceptibility to noninsulin-dependent diabetes mellitus

(NIDDM) [MIM:125853]; also known as diabetes mellitus type 2

4 diseases for MCF2L2: About MalaCards

type 1 diabetes mellitus polycystic ovary syndrome diabetes mellitus nephropathy

Human Genome Epidemiology (HuGE) Navigator: MCF2L2 (4 documents)

Export disorders for MCF2L2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MCF2L2 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with MCF2L2)

Utopia: connect your pdf to the dynamic
world of online information

Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q. (PubMed id 18259684)^{1, 2} Takeuchi F.... Kato N. (2008)
Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)^{1, 2} Nagase T....Ohara O. (1998)
Family-based association study of the MCF2L2 gene and polycystic ovary syndrome. (PubMed id 19648752)^{1, 9} Zheng Q....Chen Z.J. (2009)
Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphi sms on the development of nephropathy in type 1 Diabetes Mellitus. (PubMed id 20667095)¹ Zhang D....Gu H.F. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Identification and characterization of proteins inter acting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effec ts of sirtuins. (PubMed id 19343720)¹ Law I.K....Wang Y. (2009)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)² Sjoeblom T.... Velculescu V.E. (2006)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)² Muzny D.M....Gibbs R.A. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23101	HGNC: 30319	AceView: MCF2L2	Ensembl:ENSG00000053524	euGenes: HUgn23101
ECgene: MCF2L2	H-InvDB: MCF2L2

(According to HUGE)
About This Section

HUGE: KIAA0861

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MCF2L2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MCF2L2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MCF2L2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MCF2L2 gene:
Search GeneIP for patents involving MCF2L2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for MCF2L2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCF2L2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MCF2L2
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for MCF2L2		OriGene 3'-UTR Clone for MCF2L2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCF2L2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCF2L2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MCF2L2		OriGene Custom Protein Services for MCF2L2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MCF2L2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MCF2L2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCF2L2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MCF2L2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCF2L2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCF2L2

	GenScript Custom Purified and Recombinant Proteins Services for MCF2L2		GenScript cDNA clones with any tag delivered in your preferred vector for MCF2L2
	GenScript Custom Assay Services for MCF2L2		GenScript Custom Superior Antibodies Services for MCF2L2
	GenScript Custom overexpressing Cell Line Services for MCF2L2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in MCF2L2 promoter
	Search Chromatin IP Primers for MCF2L2
	RT² qPCR Primer Assay in human, mouse / rat MCF2L2
	Search GNC Networks for MCF2L2
	SABiosciences Custom PCR Arrays for MCF2L2

Search Tocris compounds for MCF2L2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	MCF2L2 antibodies

	Antibodies for MCF2L2
	See all of Abcam's Antibodies, Kits and Proteins for MCF2L2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

MCF2L2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for MCF2L2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCF2L2

	SwitchGear 3'UTR luciferase reporter plasmids for MCF2L2
	SwitchGear Promoter luciferase reporter plasmids for MCF2L2

ThermoFisher Antibody for MCF2L2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCF2L2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MCF2L2

Sirion Biotech Customized:

	stable knockdown cell line services for MCF2L2
	inducible knockdown cell line services for MCF2L2
	design and validation of potent shRNA sequences against MCF2L2
	adenovirus for potent knockdown of MCF2L2
	adenovirus for overexpression of MCF2L2
	stable overexpressing cell line services for MCF2L2
	inducible overexpressing cell line services for MCF2L2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MCF2L2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

MCF2L2 Gene

MCF.2 cell line derived transforming sequence-like 2

Aliases
for MCF2L2 gene

Summaries
for MCF2L2 gene

Genomic Views
for MCF2L2 gene

Proteins
for MCF2L2 gene

Protein Domains /
Families
for MCF2L2 gene

Function
for MCF2L2 gene

Pathways & Interactions
for MCF2L2 gene

Drugs & Compounds
for MCF2L2 gene

Transcripts
for MCF2L2 gene

Expression
for MCF2L2 gene

Orthologs
for MCF2L2 gene

Paralogs
for MCF2L2 gene

Genomic Variants
for MCF2L2 gene

Disorders / Diseases
for MCF2L2 gene

Publications
for MCF2L2 gene

External Searches for MCF2L2 gene

Genome Databases showing MCF2L2 gene

Other Databases showing MCF2L2 gene

Specialized Databases showing MCF2L2 gene

Intellectual Property
for MCF2L2 gene

Products
for MCF2L2 gene

View Random Gene

Advanced Search

Export list of displayed genes

MCF2L2 Gene

MCF.2 cell line derived transforming sequence-like 2

Aliasesfor MCF2L2 gene

Summariesfor MCF2L2 gene

Genomic Viewsfor MCF2L2 gene

Proteinsfor MCF2L2 gene

Protein Domains /Familiesfor MCF2L2 gene

Functionfor MCF2L2 gene

Pathways & Interactionsfor MCF2L2 gene

Drugs & Compoundsfor MCF2L2 gene

Transcriptsfor MCF2L2 gene

Expression for MCF2L2 gene

Orthologsfor MCF2L2 gene

Paralogsfor MCF2L2 gene

Genomic Variantsfor MCF2L2 gene

Disorders / Diseasesfor MCF2L2 gene

Publicationsfor MCF2L2 gene

External Searches for MCF2L2 gene

Genome Databases showing MCF2L2 gene

Other Databases showing MCF2L2 gene

Specialized Databases showing MCF2L2 gene

Intellectual Propertyfor MCF2L2 gene

Productsfor MCF2L2 gene

View Random Gene

Aliases
for MCF2L2 gene

Summaries
for MCF2L2 gene

Genomic Views
for MCF2L2 gene

Proteins
for MCF2L2 gene

Protein Domains /
Families
for MCF2L2 gene

Function
for MCF2L2 gene

Pathways & Interactions
for MCF2L2 gene

Drugs & Compounds
for MCF2L2 gene

Transcripts
for MCF2L2 gene

Expression
for MCF2L2 gene

Orthologs
for MCF2L2 gene

Paralogs
for MCF2L2 gene

Genomic Variants
for MCF2L2 gene

Disorders / Diseases
for MCF2L2 gene

Publications
for MCF2L2 gene

Intellectual Property
for MCF2L2 gene

Products
for MCF2L2 gene