Aliases for MCF2L Gene
External Ids for MCF2L Gene
Previous GeneCards Identifiers for MCF2L Gene
GeneCards Summary for MCF2L Gene
MCF2L (MCF.2 Cell Line Derived Transforming Sequence-Like) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and RhoGDI Pathway. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity and 1-phosphatidylinositol binding. An important paralog of this gene is ARHGEF40.
UniProtKB/Swiss-Prot for MCF2L Gene
Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42.