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MCF2 Gene

protein-coding GIFtS: 59

GC0XM138491

MCF.2 cell line derived transforming sequence
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DBL ^¹, ², ³, ⁵
OTTHUMP00000024156 ^²

Descriptions
MCF.2 cell line derived transforming sequence ^²
Oncogene MCF2 (oncogene DBL) ^²
Proto-oncogene MCF-2 ^³

External Ids
HGNC: 6940¹
Entrez Gene: 4168²
UniProtKB: P10911³
Ensembl: ENSG00000101977⁷

Search outside databases for aliases for MCF2 gene

Previous GC identifers: GC0XM133248 GC0XM135521 GC0XM136608 GC0XM137369 GC0XM138389

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MCF2:

MCF2 is a member of a large family of GDP-GTP exchange factors that modulate the activity of small

GTPases of the Rho family. Five-prime recombinations result in the loss of N-terminal codons,

producing MCF2 variants with oncogenic potential.[supplied by OMIM]

UniProtKB/Swiss-Prot: MCF2_HUMAN, P10911

Function: Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases.

Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the

GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits

decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward

RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL

oncogene is active toward RHOA, RAC1 and CDC42

Gene Wiki entry for MCF2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MCF2 gene

Entrez Gene cytogenetic band: Xq27 Ensembl cytogenetic band: Xq27.1 HGNC cytogenetic band: Xq26.3-q27.1

MCF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM138491: (about GC identifiers)

Start:	138,491,596 bp from pter
End:	138,618,047 bp from pter
Size:	126,452 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000023.9 NT_011786.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MCF2_HUMAN, P10911 (See protein sequence)

Recommended Name: Proto-oncogene DBL

Size: 925 amino acids; 107673 Da

Subunit: Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate

(PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P). May

interact with CCPG1

Subcellular location: Cytoplasm

Subcellular location: Isoform 1: Membrane

Subcellular location: Isoform 3: Membrane. Note=Colocalizes with CDC42 to plasma membrane

Secondary accessions: P14919 Q5JYJ4 Q8IUF3 Q8IUF4 Q9UJB3

Alternative splicing: 4 isoforms: P10911-1 P10911-2 P10911-3 P10911-4

REFSEQ proteins (2 alternative transcripts):

NP_001093325.1 NP_005360.3

ENSEMBL proteins:

ENSP00000359605 ENSP00000359610 ENSP00000359608 ENSP00000342204

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005624	membrane fraction	TAS	3281159
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	TAS	3281159
GO:0005856	cytoskeleton	TAS	3056717

About this table

Antibodies for MCF2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for MCF2 (MCF2/Dbl)
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for MCF2

Assays for MCF2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P10911

ProtoNet protein and cluster: P10911

4 Blocks protein families:

IPB000219 DH domain

IPB001849 Pleckstrin-like

IPB002017 Spectrin repeat

IPB003957 CCAAT-binding transcription factor subunit A signature

UniProtKB/Swiss-Prot: MCF2_HUMAN, P10911

Domain: The CRAL-TRIO domain is involved in interaction with inositol phospholipids

Domain: The DH domain is essential for transforming activity and directly catalyzes GDP-GTP

exchange activity. It may interact with CCPG1

Similarity: Belongs to the MCF2 family

Similarity: Contains 1 CRAL-TRIO domain

Similarity: Contains 1 DH (DBL-homology) domain

Similarity: Contains 1 PH domain

Similarity: Contains 1 spectrin repeat

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MCF2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005369

Applied Biosystems Silencer® siRNAs for MCF2

Sigma-Aldrich siRNA for MCF2

Sigma-Aldrich shRNA Panels and shRNA for MCF2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001099855
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001099855
untagged cDNA clones in CMV expression vector (see all 3): AL117234

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001099855

UniProtKB/Swiss-Prot: MCF2_HUMAN, P10911

Function: Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases.

Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the

GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits

decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward

RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL

oncogene is active toward RHOA, RAC1 and CDC42

Genatlas biochemistry entry for MCF2:

transforming sequence,MCF.2 cell line derived,highly expressed in brain,specifically activating

CDC42 and not RAC or RHOA

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mcf2):

behavior/neurological

nervous system

reproductive system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005085	guanyl-nucleotide exchange factor activity	IEA	--
GO:0005089	Rho guanyl-nucleotide exchange factor activity	IEA	--
GO:0005515	protein binding	IPI	18470881

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for MCF2

5/99 Interacting proteins for MCF2 (P10911^{1, 2} ENSP00000359610³) via UniProtKB, MINT, and/or STRING (see all 99 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RDX	P35241², ENSP00000342830³	MINT-17859 MINT-17858 STRING (score=.956)
NME1	P15531¹	EBI-1914514, EBI-741141
CDC42P2	ENSP00000314458³	STRING (score=.998)
RHOG	ENSP00000339467³	STRING (score=.998)
RAC2	ENSP00000249071³	STRING (score=.981)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007242	intracellular signaling cascade	IEA	--
GO:0035023	regulation of Rho protein signal transduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MCF2
6 Novoseek chemical compound relationships for MCF2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gdp	81.00	22	9681826 (2), 8570171 (1), 8969170 (1), 10518015 (1) (see all 17)
gtp	73.04	14	9681826 (2), 8969170 (1), 11007481 (1), 15817389 (1) (see all 12)
tyrosine	30.70	9	10652228 (5), 11007481 (2), 12496381 (1)
threonine	0.93	1	11337492 (1)
lipid	0.00	1	11577097 (1)
calcium	0.00	2	9141492 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MCF2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005369

Sigma-Aldrich siRNA for MCF2

Sigma-Aldrich shRNA Panels and shRNA for MCF2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001099855 NM_005369

REFSEQ mRNAs for MCF2 gene (2 alternative transcripts):

NM_001099855.1 NM_005369.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001099855 NM_005369

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001099855
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001099855
                                 untagged cDNA clones in CMV expression vector (see all 3): AL117234

Additional cDNA sequence:

AB085901.1 AB085902.1 AK296488.1 AK296529.1 AK302957.1 AK313900.1 AK316416.1 AL117234.1

BC151247.1 J03639.1 X12556.1 X13230.1

5 DOTS entries:

DT.95366728 DT.92070670 DT.92070671 DT.95366727 DT.121301235

24 AceView cDNA sequences:

AL117234 BQ189571 AL040486 BQ632854 BX093553 AB085901 BQ632565 AB085902

NM_005369 AL120131 AL046410 AW341436 BF062094 X12556 BG205068 X13230

N35192 AV752834 AI004109 AA610032 N23406 J03639 AA758713 BU568480

highest scoring ESTs for MCF2:

X12556 AL117234 AL120131 BQ632854 AA610032 AA758713 AB085901 AB085902 AI004109 AL040486

Unigene Cluster for MCF2:

MCF.2 cell line derived transforming sequence

Hs.387262 [show with all ESTs]

Unigene Representative Sequence: NM_001099855

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000370573 ENST00000370578 ENST00000370576 ENST00000338585

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MCF2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MCF2

¹ / ² / ³

7 probe-sets matching MCF2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1807_g_at²^{, 3}	U95-A	1	1.00	1.00	0.95	1.25	X12556	1.00	1.00	1.00	1
1806_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.06	X12556	1.00	1.00	1.00	1
217004_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X13230	0.60	1.00	0.82	1
208017_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005369	0.60	1.00	0.82	1
1555313_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217004_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208017_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTGTAATTCT

SOURCE GeneReport for Unigene cluster: Hs.387262
Expression variation in blood from EXPOLDB for MCF2
UniProtKB/Swiss-Prot: MCF2_HUMAN, P10911
Tissue specificity: Isoform 1 is expressed only in brain. Isoform 3 is expressed in heart, kidney,
spleen, liver and testis. Isoform 4 is expressed in brain, heart, kidney, testis, placenta,
stomach and peripheral blood. The protein is detectable in brain, heart, kidney, intestine,
muscle, lung and testis

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MCF2 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MCF2¹	--	MCF.2 cell line derived transforming sequence	89.35(n) 88.8(a)	492176 XM_549296.2 XP_549296.2
cow (Bos taurus)	MCF2¹	--	MCF.2 cell line derived transforming sequence	88.47(n) 86.33(a)	532185 XM_610695.3 XP_610695.3
rat (Rattus norvegicus)	Mcf2¹	--	MCF.2 cell line derived transforming sequence	82.3(n) 78.36(a)	317598 XM_229172.4 XP_229172.3
mouse (Mus musculus)	Mcf2^{1, 5}	X (22.50 cM)⁵	mcf.2 transforming sequence^{1, 5}	80.74(n)¹ 75.47(a)¹	109904¹ NM_133197.2¹ NP_573460.1¹ AA591884⁵ AB052945⁵ (see all 14)
chicken (Gallus gallus)	MCF2¹	--	MCF.2 cell line derived transforming sequence	69.24(n) 65.67(a)	422253 XM_420239.2 XP_420239.2

About this table Species with no ortholog for MCF2

ENSEMBL Gene Tree for MCF2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MCF2 gene

MCF2L² KIAA1755² MCF2L2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/485 NCBI SNPs in MCF2 are shown (see all 485 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 121)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2891098^1,2	A,C,F,H,O	138553126(-)	`TTCAAA/GCAAGT`	2	--	int¹ ng3¹		13	EU EA WA NA	921
	rs5907612^1,2	A,C,F,H	138553877(+)	`AGACCA/GGAGCA`	2	--	ng3¹ int¹		4	EU NA	215
	rs2206575^1,2	C,F,H,O	138552595(+)	`TTCCTC/ACAATT`	2	--	ut5¹ int¹		11	EU EA WA NA	770
	rs6635886^1,2	A,F,H	138491398(+)	`TTTGCT/CTGGAG`	2	--	ng5¹		4	EU EA WA	418
	rs17340169^1,2	C,F,H	138552584(+)	`GAGTTA/GACACA`	2	--	int¹ ut5¹		11	NA EU EA WA	742
	rs926563^1,2	C,H	138552391(+)	`GCAACG/ATTGAT`	2	--	int¹ ut5¹		5	MN EU EA WA	604
--	rs12387194^1,2	H	138529453(+)	`TTTTTG/TTTTTA`	2	Q/K	mis¹		2	EU WA	232
	rs2235708^1,2	A,C,F,H	138506410(+)	`TATCTG/ATCAGA`	2	D/D	syn¹ ese³		8	EU EA WA	628
	rs1051619^1,2	C,F,H,O	138507378(-)	`GAAGGA/TTCTGC`	2	G/G	syn¹		12	MN NA EU EA WA	1007
	rs3128285^1,2	H	138496276(+)	`AATTCA/CGTTTC`	2	T/T	syn¹		4	EU EA WA	410

About this table

HapMap Linkage Disequilibrium images for MCF2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 311030

UniProtKB/Swiss-Prot: MCF2_HUMAN, P10911

MCF2 and DBL represent two activated versions of the same proto-oncogene

5 Novoseek disease relationships for MCF2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma b-cell	13.33	2	15163014 (1), 15306850 (1)
dysplasia	7.91	3	8969170 (1), 8994827 (1), 9671479 (1)
tumors	0.00	1	2098495 (1)
lymphoma	0.00	1	15163014 (1)
leukemia	0.00	2	15276214 (1), 15163014 (1)

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Tumor Gene Database: MCF2

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/175 PubMed articles for MCF2 gene (see all 175 ):

Activation of a mcf.2 oncogene by deletion of amino-terminal coding sequences. (PubMed id 2577874)^{2, 3, 4} Noguchi T.... Birnbaum D. (1988)
Alternative splicing variants of the human DBL (MCF-2) proto- oncogene. (PubMed id 12445822)^{1, 3, 4} Komai K.... Shiozawa S. (2002)
Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23. (PubMed id 1611909)^{1, 2, 3} Galland F....Birnbaum D. (1992)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)
Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product. (PubMed id 8276860)^{3, 4} Hart M.J.... Zheng Y. (1994)
A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr. (PubMed id 2065022)^{3, 4} Ron D.... Eva A. (1991)
The predicted DBL oncogene product defines a distinct class of transforming proteins. (PubMed id 3281159)^{3, 4} Eva A.... Aaronson S.A. (1988)
Molecular cloning and characterization of the human dbl proto- oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells. (PubMed id 3056717)^{3, 4} Ron D.... Eva A. (1988)
Characterization of novel splicing variants of the mouse MCF-2 (DBL) proto-oncogene. (PubMed id 13679059)^{1, 3} Komai K....Shiozawa S. (2003)
Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation. (PubMed id 10854437)^{1, 3} Zhu K....Zheng Y. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4168	HGNC: 6940	AceView: MCF2	Ensembl:ENSG00000101977	euGenes: HUgn4168
ECgene: MCF2	H-InvDB: MCF2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MCF2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for MCF2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MCF2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MCF2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MCF2		Browse antibodies at Sigma-Aldrich
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	Lentivirus-delivered shRNAs for MCF2		Browse small molecules at Sigma-Aldrich
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MCF2 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for MCF2

Summaries
for MCF2

Genomic Location
for MCF2

Proteins
for MCF2

Protein Domains/
Families
for MCF2

Gene Function
for MCF2

Pathways & Interactions
for MCF2

Drugs & Compounds
for MCF2

Transcripts
for MCF2

Expression
for MCF2

Orthologs
for MCF2

Paralogs
for MCF2

SNPs/Variants
for MCF2

Disorders & Mutations
for MCF2

Medical News
for MCF2

Publications
for MCF2

Search for MCF2

Genome Databases showing MCF2

Other Databases showing MCF2

Specialized Databases showing MCF2

Licensable Technologies
for MCF2

Services
for MCF2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MCF2 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor MCF2

Summariesfor MCF2

Genomic Locationfor MCF2

Proteinsfor MCF2

Protein Domains/Familiesfor MCF2

Gene Functionfor MCF2

Pathways & Interactionsfor MCF2

Drugs & Compoundsfor MCF2

Transcriptsfor MCF2

Expression for MCF2

Orthologsfor MCF2

Paralogsfor MCF2

SNPs/Variantsfor MCF2

Disorders & Mutationsfor MCF2

Medical Newsfor MCF2

Publicationsfor MCF2

Search for MCF2

Genome Databases showing MCF2

Other Databases showing MCF2

Specialized Databases showing MCF2

Licensable Technologiesfor MCF2

Servicesfor MCF2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MCF2

Summaries
for MCF2

Genomic Location
for MCF2

Proteins
for MCF2

Protein Domains/
Families
for MCF2

Gene Function
for MCF2

Pathways & Interactions
for MCF2

Drugs & Compounds
for MCF2

Transcripts
for MCF2

Expression
for MCF2

Orthologs
for MCF2

Paralogs
for MCF2

SNPs/Variants
for MCF2

Disorders & Mutations
for MCF2

Medical News
for MCF2

Publications
for MCF2

Licensable Technologies
for MCF2

Services
for MCF2