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Aliases for MCEMP1 Gene

Aliases for MCEMP1 Gene

  • Mast Cell Expressed Membrane Protein 1 2 3 5
  • C19orf59 3 4
  • Mast Cell-Expressed Membrane Protein 1 3
  • Chromosome 19 Open Reading Frame 59 2

External Ids for MCEMP1 Gene

Previous HGNC Symbols for MCEMP1 Gene

  • C19orf59

Previous GeneCards Identifiers for MCEMP1 Gene

  • GC19P007648

Summaries for MCEMP1 Gene

Entrez Gene Summary for MCEMP1 Gene

  • This gene encodes a single-pass transmembrane protein. Based on its expression pattern, it is speculated to be involved in regulating mast cell differentiation or immune responses. [provided by RefSeq, Jul 2008]

GeneCards Summary for MCEMP1 Gene

MCEMP1 (Mast Cell Expressed Membrane Protein 1) is a Protein Coding gene. Among its related pathways are Innate Immune System.

Additional gene information for MCEMP1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCEMP1 Gene

Genomics for MCEMP1 Gene

Regulatory Elements for MCEMP1 Gene

Enhancers for MCEMP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H007673 1.3 FANTOM5 Ensembl ENCODE 17.8 -2.1 -2137 1 PKNOX1 FEZF1 GATA3 ZNF366 NFYB ZNF350 ZBTB20 SP3 NFYA ZNF621 MCEMP1 XAB2 HNRNPM ZNF414 ZNF557 ELAVL1 SNAPC2 MCOLN1 STXBP2 PEX11G
GH19H007700 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +27.9 27860 7 HDGF PKNOX1 YBX1 ZNF143 ZNF207 ATF7 RUNX3 JUNB ZNF592 NBN ELAVL1 HNRNPM XAB2 STXBP2 FCER2 PEX11G MAP2K7 CD209 CLEC4G RPL21P129
GH19H007655 1.1 FANTOM5 Ensembl ENCODE 16.2 -20.7 -20695 1 POLR2A HLF MCEMP1 STXBP2 XAB2 MCOLN1 PEX11G PNPLA6 RETN RPS27AP19 ENSG00000268204
GH19H007543 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -131.9 -131902 3 POLR2A BCL11A BCL11B NR2F2 SPI1 EGR2 MCOLN1 MCEMP1 PEX11G PNPLA6 STXBP2 RETN GC19M007532 CAMSAP3
GH19H007799 1.1 Ensembl ENCODE 12.3 +123.3 123273 1 GTF2F1 CTCF KLF17 CHD7 RAD21 RELA RFX5 E2F1 CC2D1A ZFHX2 TRAPPC5 MCEMP1 CLEC4G RPL21P129 CD209 PET100 XAB2 LRRC8E PRR36 CLEC4GP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MCEMP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MCEMP1 Gene

Chromosome:
19
Start:
7,676,628 bp from pter
End:
7,679,833 bp from pter
Size:
3,206 bases
Orientation:
Plus strand

Genomic View for MCEMP1 Gene

Genes around MCEMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCEMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCEMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCEMP1 Gene

Proteins for MCEMP1 Gene

  • Protein details for MCEMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX19-MCEM1_HUMAN
    Recommended name:
    Mast cell-expressed membrane protein 1
    Protein Accession:
    Q8IX19
    Secondary Accessions:
    • Q8IX20

    Protein attributes for MCEMP1 Gene

    Size:
    187 amino acids
    Molecular mass:
    21229 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MCEMP1 Gene

Post-translational modifications for MCEMP1 Gene

  • Glycosylation at Asn124
  • Modification sites at PhosphoSitePlus

Other Protein References for MCEMP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MCEMP1 Gene

Domains & Families for MCEMP1 Gene

Gene Families for MCEMP1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MCEMP1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for MCEMP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MCEMP1: view

No data available for UniProtKB/Swiss-Prot for MCEMP1 Gene

Function for MCEMP1 Gene

Phenotypes From GWAS Catalog for MCEMP1 Gene

genes like me logo Genes that share phenotypes with MCEMP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MCEMP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MCEMP1 Gene

Localization for MCEMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCEMP1 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCEMP1 gene
Compartment Confidence
plasma membrane 5
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MCEMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0035579 specific granule membrane TAS --
GO:0070821 tertiary granule membrane TAS --
genes like me logo Genes that share ontologies with MCEMP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MCEMP1 Gene

Pathways & Interactions for MCEMP1 Gene

genes like me logo Genes that share pathways with MCEMP1: view

Pathways by source for MCEMP1 Gene

3 Reactome pathways for MCEMP1 Gene

Interacting Proteins for MCEMP1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000329920%0d%0a9606.ENSP00000375691%0d%0a
Selected Interacting proteins: ENSP00000329920 Q8IX19-MCEM1_HUMAN for MCEMP1 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for MCEMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with MCEMP1: view

No data available for SIGNOR curated interactions for MCEMP1 Gene

Drugs & Compounds for MCEMP1 Gene

No Compound Related Data Available

Transcripts for MCEMP1 Gene

mRNA/cDNA for MCEMP1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MCEMP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MCEMP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2: - -
SP3:

Relevant External Links for MCEMP1 Gene

GeneLoc Exon Structure for
MCEMP1
ECgene alternative splicing isoforms for
MCEMP1

Expression for MCEMP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MCEMP1 Gene

Protein differential expression in normal tissues from HIPED for MCEMP1 Gene

This gene is overexpressed in Monocytes (28.0), Blymphocyte (11.4), Neutrophil (10.7), and Peripheral blood mononuclear cells (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MCEMP1 Gene



Protein tissue co-expression partners for MCEMP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MCEMP1 Gene:

MCEMP1

mRNA Expression by UniProt/SwissProt for MCEMP1 Gene:

Q8IX19-MCEM1_HUMAN
Tissue specificity: Expressed specifically in mast cells. Found primarily in lung.

Evidence on tissue expression from TISSUES for MCEMP1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with MCEMP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCEMP1 Gene

Orthologs for MCEMP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MCEMP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf59 33 34
  • 98.75 (n)
dog
(Canis familiaris)
Mammalia C20H19orf59 33
  • 73.3 (n)
C19orf59 34
  • 47 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C7H19orf59 33
  • 65.2 (n)
C19orf59 34
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1565374 33
  • 63.92 (n)
mouse
(Mus musculus)
Mammalia 1810033B17Rik 33 34
  • 63.67 (n)
Mcemp1 16
Species where no ortholog for MCEMP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MCEMP1 Gene

ENSEMBL:
Gene Tree for MCEMP1 (if available)
TreeFam:
Gene Tree for MCEMP1 (if available)

Paralogs for MCEMP1 Gene

(1) SIMAP similar genes for MCEMP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MCEMP1: view

No data available for Paralogs for MCEMP1 Gene

Variants for MCEMP1 Gene

Sequence variations from dbSNP and Humsavar for MCEMP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000274168 -- 7,675,653(+) GAAGC(C/T)GAGGA upstream-variant-2KB
rs1000646037 -- 7,675,210(+) TTTGG(A/G)AGACC upstream-variant-2KB
rs1001094088 -- 7,679,302(+) CGTGC(-/GTGT)GTGTG upstream-variant-2KB, utr-variant-3-prime
rs1001908911 -- 7,676,597(+) CTCCA(C/T)GGGGA upstream-variant-2KB
rs1001967496 -- 7,679,156(+) GAAGA(C/T)GGGGC upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MCEMP1 Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV gain 17911159
nsv1060887 CNV gain 25217958
nsv1061452 CNV gain 25217958
nsv833731 CNV loss 17160897
nsv833732 CNV gain 17160897
nsv953959 CNV deletion 24416366

Variation tolerance for MCEMP1 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCEMP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCEMP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCEMP1 Gene

Disorders for MCEMP1 Gene

Relevant External Links for MCEMP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCEMP1

No disorders were found for MCEMP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MCEMP1 Gene

Publications for MCEMP1 Gene

  1. Identification and expression of a new type II transmembrane protein in human mast cells. (PMID: 15953541) Li K … Yao Z (Genomics 2005) 2 3 4 22 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis. (PMID: 26846866) Raman K … Paré G (Stroke 2016) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for MCEMP1 Gene

Sources for MCEMP1 Gene

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