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Aliases for MCEMP1 Gene

Aliases for MCEMP1 Gene

  • Mast Cell Expressed Membrane Protein 1 2 3 5
  • C19orf59 3 4
  • Mast Cell-Expressed Membrane Protein 1 3
  • Chromosome 19 Open Reading Frame 59 2

External Ids for MCEMP1 Gene

Previous HGNC Symbols for MCEMP1 Gene

  • C19orf59

Previous GeneCards Identifiers for MCEMP1 Gene

  • GC19P007648

Summaries for MCEMP1 Gene

Entrez Gene Summary for MCEMP1 Gene

  • This gene encodes a single-pass transmembrane protein. Based on its expression pattern, it is speculated to be involved in regulating mast cell differentiation or immune responses. [provided by RefSeq, Jul 2008]

GeneCards Summary for MCEMP1 Gene

MCEMP1 (Mast Cell Expressed Membrane Protein 1) is a Protein Coding gene. Among its related pathways are Immune System.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCEMP1 Gene

Genomics for MCEMP1 Gene

Regulatory Elements for MCEMP1 Gene

Enhancers for MCEMP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F007673 0.8 FANTOM5 ENCODE 17.8 -2.1 -2137 1.2 CBX3 PKNOX1 DDX20 FEZF1 GATA3 ZNF366 NFYB EED ZBTB20 SP3 MCEMP1 MCOLN1 STXBP2 PEX11G PNPLA6 RETN
GH19F007655 1.7 FANTOM5 Ensembl ENCODE 16.2 -19.3 -19328 4.2 PKNOX1 ZNF384 BMI1 RFX5 ZFHX2 POLR2A SCRT2 NFYB EED NR2F6 MCEMP1 XAB2 PCP2 STXBP2 MCOLN1 PEX11G ENSG00000268204 PNPLA6 RETN RPS27AP19
GH19F007713 0.9 Ensembl ENCODE 13.1 +38.0 37995 1.6 MBD2 CTBP1 GATA3 PKNOX1 DPF2 MNT CD209 TRAPPC5 MCEMP1 RPL21P129 CAMSAP3 CLEC4G FCER2 XAB2 LOC105372262
GH19F007715 0.2 Ensembl 13.1 +39.1 39073 0.2 MNT TRAPPC5 MCEMP1 CD209 RPL21P129 CAMSAP3 LOC105372262 CLEC4G
GH19F007791 0.5 ENCODE 12.6 +115.7 115743 1.6 ATF1 PKNOX1 L3MBTL2 HINFP RNF2 NRF1 REST ARID1B GATA3 CTBP1 CLEC4GP1 TRAPPC5 MCEMP1 CD209 RPL21P129 CLEC4G CAMSAP3 EXOSC3P2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MCEMP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MCEMP1 Gene

Chromosome:
19
Start:
7,676,628 bp from pter
End:
7,679,833 bp from pter
Size:
3,206 bases
Orientation:
Plus strand

Genomic View for MCEMP1 Gene

Genes around MCEMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCEMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCEMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCEMP1 Gene

Proteins for MCEMP1 Gene

  • Protein details for MCEMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX19-MCEM1_HUMAN
    Recommended name:
    Mast cell-expressed membrane protein 1
    Protein Accession:
    Q8IX19
    Secondary Accessions:
    • Q8IX20

    Protein attributes for MCEMP1 Gene

    Size:
    187 amino acids
    Molecular mass:
    21229 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MCEMP1 Gene

Post-translational modifications for MCEMP1 Gene

  • Glycosylation at Asn 124
  • Modification sites at PhosphoSitePlus

Other Protein References for MCEMP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MCEMP1 Gene

Domains & Families for MCEMP1 Gene

Protein Domains for MCEMP1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for MCEMP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MCEMP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MCEMP1 Gene

Function for MCEMP1 Gene

genes like me logo Genes that share phenotypes with MCEMP1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MCEMP1 Gene

Localization for MCEMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCEMP1 Gene

Membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for MCEMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MCEMP1: view

No data available for Subcellular locations from COMPARTMENTS for MCEMP1 Gene

Pathways & Interactions for MCEMP1 Gene

SuperPathways for MCEMP1 Gene

SuperPathway Contained pathways
1 Immune System
genes like me logo Genes that share pathways with MCEMP1: view

Pathways by source for MCEMP1 Gene

2 Reactome pathways for MCEMP1 Gene

Interacting Proteins for MCEMP1 Gene

Selected Interacting proteins: Q8IX19-MCEM1_HUMAN for MCEMP1 Gene via IID

Symbol External ID(s) Details
JOSD2
YWHAE

Gene Ontology (GO) - Biological Process for MCEMP1 Gene

None

No data available for SIGNOR curated interactions for MCEMP1 Gene

Transcripts for MCEMP1 Gene

mRNA/cDNA for MCEMP1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCEMP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2: - -
SP3:

Relevant External Links for MCEMP1 Gene

GeneLoc Exon Structure for
MCEMP1
ECgene alternative splicing isoforms for
MCEMP1

Expression for MCEMP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MCEMP1 Gene

Protein differential expression in normal tissues from HIPED for MCEMP1 Gene

This gene is overexpressed in Monocytes (28.0), Blymphocyte (11.4), Neutrophil (10.7), and Peripheral blood mononuclear cells (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MCEMP1 Gene



Protein tissue co-expression partners for MCEMP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MCEMP1 Gene:

MCEMP1

mRNA Expression by UniProt/SwissProt for MCEMP1 Gene:

Q8IX19-MCEM1_HUMAN
Tissue specificity: Expressed specifically in mast cells. Found primarily in lung.
genes like me logo Genes that share expression patterns with MCEMP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MCEMP1 Gene

Orthologs for MCEMP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MCEMP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf59 34 35
  • 98.75 (n)
dog
(Canis familiaris)
Mammalia C20H19orf59 34
  • 73.3 (n)
C19orf59 35
  • 47 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C7H19orf59 34
  • 65.2 (n)
C19orf59 35
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1565374 34
  • 63.92 (n)
mouse
(Mus musculus)
Mammalia 1810033B17Rik 34 35
  • 63.67 (n)
Mcemp1 16
Species where no ortholog for MCEMP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MCEMP1 Gene

ENSEMBL:
Gene Tree for MCEMP1 (if available)
TreeFam:
Gene Tree for MCEMP1 (if available)

Paralogs for MCEMP1 Gene

(1) SIMAP similar genes for MCEMP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MCEMP1: view

No data available for Paralogs for MCEMP1 Gene

Variants for MCEMP1 Gene

Sequence variations from dbSNP and Humsavar for MCEMP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401670 -- 7,677,916(+) TGTGA(C/T)GGTGA intron-variant
rs10409343 -- 7,678,959(+) AAATC(C/T)TGGAG upstream-variant-2KB, reference, synonymous-codon
rs10411016 -- 7,680,157(+) CCTAA(G/T)GTACT downstream-variant-500B, upstream-variant-2KB
rs111420062 -- 7,679,270(+) GTCTC(A/G)GAGTT upstream-variant-2KB, utr-variant-3-prime
rs111599207 -- 7,679,892(+) GGAGA(A/G)TCTGC downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MCEMP1 Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV gain 17911159
nsv1060887 CNV gain 25217958
nsv1061452 CNV gain 25217958
nsv833731 CNV loss 17160897
nsv833732 CNV gain 17160897
nsv953959 CNV deletion 24416366

Variation tolerance for MCEMP1 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCEMP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCEMP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCEMP1 Gene

Disorders for MCEMP1 Gene

Relevant External Links for MCEMP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCEMP1

No disorders were found for MCEMP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MCEMP1 Gene

Publications for MCEMP1 Gene

  1. Identification and expression of a new type II transmembrane protein in human mast cells. (PMID: 15953541) Li K. … Yao Z. (Genomics 2005) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis. (PMID: 26846866) Raman K. … ParAc G. (Stroke 2016) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1. (PMID: 23383108) Denner J. … AkyA1z L. (PLoS ONE 2013) 3 64

Products for MCEMP1 Gene

Sources for MCEMP1 Gene

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