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Aliases for MCEMP1 Gene

Aliases for MCEMP1 Gene

  • Mast Cell-Expressed Membrane Protein 1 2 3
  • C19orf59 3 4
  • Chromosome 19 Open Reading Frame 59 2

External Ids for MCEMP1 Gene

Previous HGNC Symbols for MCEMP1 Gene

  • C19orf59

Previous GeneCards Identifiers for MCEMP1 Gene

  • GC19P007648

Summaries for MCEMP1 Gene

Entrez Gene Summary for MCEMP1 Gene

  • This gene encodes a single-pass transmembrane protein. Based on its expression pattern, it is speculated to be involved in regulating mast cell differentiation or immune responses. [provided by RefSeq, Jul 2008]

GeneCards Summary for MCEMP1 Gene

MCEMP1 (Mast Cell-Expressed Membrane Protein 1) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCEMP1 Gene

Genomics for MCEMP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MCEMP1 Gene

7,676,628 bp from pter
7,679,833 bp from pter
3,206 bases
Plus strand

Genomic View for MCEMP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MCEMP1 Gene

No data available for Regulatory Elements for MCEMP1 Gene

Proteins for MCEMP1 Gene

  • Protein details for MCEMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mast cell-expressed membrane protein 1
    Protein Accession:
    Secondary Accessions:
    • Q8IX20

    Protein attributes for MCEMP1 Gene

    187 amino acids
    Molecular mass:
    21229 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MCEMP1 Gene

Proteomics data for MCEMP1 Gene at MOPED

Post-translational modifications for MCEMP1 Gene

  • Glycosylation at Asn 124
  • Modification sites at PhosphoSitePlus

Other Protein References for MCEMP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MCEMP1 Gene

Domains & Families for MCEMP1 Gene

Protein Domains for MCEMP1 Gene


Suggested Antigen Peptide Sequences for MCEMP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MCEMP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MCEMP1 Gene

Function for MCEMP1 Gene

Phenotypes for MCEMP1 Gene

genes like me logo Genes that share phenotypes with MCEMP1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MCEMP1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MCEMP1 Gene

Localization for MCEMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCEMP1 Gene

Membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for MCEMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MCEMP1: view

No data available for Subcellular locations from COMPARTMENTS for MCEMP1 Gene

Pathways & Interactions for MCEMP1 Gene

SuperPathways for MCEMP1 Gene

No Data Available

Interacting Proteins for MCEMP1 Gene

Gene Ontology (GO) - Biological Process for MCEMP1 Gene


No data available for Pathways by source and SIGNOR curated interactions for MCEMP1 Gene

Drugs & Compounds for MCEMP1 Gene

No Compound Related Data Available

Transcripts for MCEMP1 Gene

mRNA/cDNA for MCEMP1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MCEMP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCEMP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2: - -

Relevant External Links for MCEMP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MCEMP1 Gene

mRNA expression in normal human tissues for MCEMP1 Gene

Protein differential expression in normal tissues from HIPED for MCEMP1 Gene

This gene is overexpressed in Monocytes (28.0), Blymphocyte (11.4), Neutrophil (10.7), and Peripheral blood mononuclear cells (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MCEMP1 Gene

mRNA Expression by UniProt/SwissProt for MCEMP1 Gene

Tissue specificity: Expressed specifically in mast cells. Found primarily in lung.
genes like me logo Genes that share expression patterns with MCEMP1: view

Protein tissue co-expression partners for MCEMP1 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MCEMP1 Gene

Orthologs for MCEMP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MCEMP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C7H19orf59 35
  • 65.2 (n)
  • 48.35 (a)
C19orf59 36
  • 45 (a)
(Canis familiaris)
Mammalia C20H19orf59 35
  • 73.3 (n)
  • 55.68 (a)
C19orf59 36
  • 47 (a)
(Mus musculus)
Mammalia 1810033B17Rik 35
  • 63.67 (n)
  • 49.1 (a)
1810033B17Rik 16
1810033B17Rik 36
  • 40 (a)
(Pan troglodytes)
Mammalia C19H19orf59 35
  • 98.75 (n)
  • 97.85 (a)
C19H19orf59 36
  • 98 (a)
(Rattus norvegicus)
Mammalia RGD1565374 35
  • 63.92 (n)
  • 48.24 (a)
Species with no ortholog for MCEMP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MCEMP1 Gene

Gene Tree for MCEMP1 (if available)
Gene Tree for MCEMP1 (if available)

Paralogs for MCEMP1 Gene

(1) SIMAP similar genes for MCEMP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MCEMP1: view

No data available for Paralogs for MCEMP1 Gene

Variants for MCEMP1 Gene

Sequence variations from dbSNP and Humsavar for MCEMP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs889183 -- 7,676,840(-) ACACT(C/T)GGAAA upstream-variant-2KB
rs3032321 -- 7,677,457(+) TGTGT(-/GT)GGTGT intron-variant
rs5826983 -- 7,677,458(+) GTGTG(-/T)GGTGT intron-variant
rs8103654 -- 7,678,617(+) TGTAG(G/T)CTCGC intron-variant
rs8107661 -- 7,677,459(+) TGTGT(A/G)GTGTG intron-variant

Variation tolerance for MCEMP1 Gene

Residual Variation Intolerance Score: 84.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCEMP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MCEMP1 Gene

Disorders for MCEMP1 Gene

Relevant External Links for MCEMP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MCEMP1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MCEMP1 Gene

Publications for MCEMP1 Gene

  1. Identification and expression of a new type II transmembrane protein in human mast cells. (PMID: 15953541) Li K. … Yao Z. (Genomics 2005) 2 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1. (PMID: 23383108) Denner J. … AkyA1z L. (PLoS ONE 2013) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 67

Products for MCEMP1 Gene

Sources for MCEMP1 Gene

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