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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MCEE Gene

protein-coding   GIFtS: 61
GCID: GC02M071336

Methylmalonyl CoA Epimerase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Methylmalonyl CoA Epimerase1 2
Glyoxalase Domain Containing 21 2
DL-Methylmalonyl-CoA Racemase2 3
GLOD22
Methylmalonyl-CoA Epimerase, Mitochondrial2
EC 5.1.99.13

External Ids:    HGNC: 167321   Entrez Gene: 846932   Ensembl: ENSG000001243707   OMIM: 6084195   UniProtKB: Q96PE73   

Export aliases for MCEE gene to outside databases

Previous GC identifers: GC02M071346 GC02M071547 GC02M071311 GC02M071248 GC02M071190 GC02M071073


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MCEE Gene:
The product of this gene catalyzes the interconversion of D- and L-methylmalonyl-CoA during the degradation of
branched chain amino acids. odd chain-length fatty acids, and other metabolites. Mutations in this gene result in
methylmalonyl-CoA epimerase deficiency, which is presented as mild to moderate methylmalonic aciduria. (provided
by RefSeq, Jul 2008)

GeneCards Summary for MCEE Gene: 
MCEE (methylmalonyl CoA epimerase) is a protein-coding gene. Diseases associated with MCEE include mcee-related methylmalonic acidemia, and methylmalonic acidemia, and among its related super-pathways are Metabolic pathways and methylmalonyl pathway. GO annotations related to this gene include methylmalonyl-CoA epimerase activity.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MCEE gene promoter:
         HOXA9   HOXA9B   Nkx5-1   E47   C/EBPalpha   IRF-2   POU2F1   POU2F1a   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMCEE promoter sequence
   Search SABiosciences Chromatin IP Primers for MCEE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCEE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.3   Ensembl cytogenetic band:  2p13.3   HGNC cytogenetic band: 2p13.3

MCEE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCEE gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M071336:  view genomic region     (about GC identifiers)

Start:
71,336,806 bp from pter      End:
71,357,394 bp from pter
Size:
20,589 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MCEE_HUMAN, Q96PE7 (See protein sequence)
Recommended Name: Methylmalonyl-CoA epimerase, mitochondrial precursor  
Size: 176 amino acids; 18749 Da
Subcellular location: Mitochondrion (Probable)
1 PDB 3D structure from and Proteopedia for MCEE:
3RMU (3D)    
Secondary accessions: Q53TP1 Q8WW63

Explore the universe of human proteins at neXtProt for MCEE: NX_Q96PE7

Explore proteomics data for MCEE at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96PE7

  • MCEE Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MCEE Protein Expression
    REFSEQ proteins: NP_115990.3  
    ENSEMBL proteins: 
     ENSP00000391140   ENSP00000244217   ENSP00000437361   ENSP00000441569  
    Reactome Protein details: Q96PE7
    Human Recombinant Protein Products for MCEE: 
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    Novus Biologicals MCEE Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for MCEE
    Cloud-Clone Corp. Proteins for MCEE 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005759mitochondrial matrix TAS--

    MCEE for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for MCEE


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR017515 MeMalonyl-CoA_epimerase

    Graphical View of Domain Structure for InterPro Entry Q96PE7

    ProtoNet protein and cluster: Q96PE7

    3 Blocks protein domains:
    IPB004360 Glyoxalase/Bleomycin resistance protein/dioxygenase domain
    IPB004361 Glyoxalase I
    IPB011588 Glyoxalase/extradiol ring-cleavage dioxygenase


    UniProtKB/Swiss-Prot: MCEE_HUMAN, Q96PE7
    Similarity: Belongs to the glyoxalase I family


    MCEE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MCEE_HUMAN, Q96PE7
    Catalytic activity: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA

         Enzyme Number (IUBMB): EC 5.1.99.11

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004493methylmalonyl-CoA epimerase activity IDA11481338
         
    MCEE for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MCEE 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MCEE About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    2Propionyl-CoA catabolism
    Propionyl-CoA catabolism0.60
    methylmalonyl pathway0.60
    32-oxobutanoate degradation I
    2-oxobutanoate degradation I0.57
    superpathway of methionine degradation0.37
    4Branched-chain amino acid catabolism
    Valine, leucine and isoleucine degradation0.39
    Propanoate metabolism0.31
    5Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
    Mitochondrial Fatty Acid Beta-Oxidation0.53

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for MCEE
        methylmalonyl pathway
    superpathway of methionine degradation
    2-oxobutanoate degradation I

    5        Reactome Pathways for MCEE
        Propionyl-CoA catabolism
    Metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism
    Metabolism of lipids and lipoproteins
    Mitochondrial Fatty Acid Beta-Oxidation


    5         Kegg Pathways  (Kegg details for MCEE):
        Valine, leucine and isoleucine degradation
    Glyoxylate and dicarboxylate metabolism
    Propanoate metabolism
    Metabolic pathways
    Carbon metabolism


    MCEE for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MCEE

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for MCEE (ENSP000002442174) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MUTENSP000002748134STRING: ENSP00000274813
    PCCAENSP000003654624STRING: ENSP00000365462
    PCCBENSP000002516544STRING: ENSP00000251654
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006635fatty acid beta-oxidation TAS--
    GO:0019626short-chain fatty acid catabolic process TAS--
    GO:0044255cellular lipid metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0046491L-methylmalonyl-CoA metabolic process IDA11481338

    MCEE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MCEE for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MCEE

    3 HMDB Compounds for MCEE    About this table
    CompoundSynonyms CAS #PubMed Ids
    Methylmalonyl-CoA(R)-methylmalonyl-CoA (see all 12)104809-02-1--
    R-Methylmalonyl-CoA 73173-92-9--
    S-Methylmalonyl-CoA(S)-Methylmalonyl-CoA (see all 2)73173-91-8--

    7 Novoseek inferred chemical compound relationships for MCEE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenosylcobalamin 86.1 1 16843692 (1)
    methylmalonic acid 82 4 17823972 (2)
    fosfomycin 72.9 2 10360943 (1), 11076500 (1)
    isoleucine 56.7 1 11470438 (1)
    vitamin b12 50.4 1 16697227 (1)
    valine 50.2 1 11470438 (1)
    methionine 39.1 1 11470438 (1)

    Search CenterWatch for drugs/clinical trials and news about MCEE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MCEE gene: 
    NM_032601.3  

    Unigene Cluster for MCEE:

    Methylmalonyl CoA epimerase
    Hs.94949  [show with all ESTs]
    Unigene Representative Sequence: CB984952
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413592 ENST00000244217(uc002shs.2) ENST00000462609 ENST00000494660
    ENST00000486135
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MCEE
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCEE

    Additional mRNA sequence: 

    AF364547.1 BC020825.1 

    6 DOTS entries:

    DT.95369217  DT.91713573  DT.40301580  DT.452403  DT.120965828  DT.100027017 

    24/123 AceView cDNA sequences (see all 123):

    AI299838 BE219105 AA376175 AF364547 BE218633 CR624276 BU753977 AV645970 
    AI201757 BF590625 AW134960 AV681851 AI927096 AI350320 AV645652 CA312248 
    AA935949 CB135530 H97986 BI962674 BI492716 BQ013538 AA535540 AA449228 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MCEE    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b
    SP1:                    -                                       
    SP2:                                                            
    SP3:                    -           -     -     -               
    SP4:                                                            


    ECgene alternative splicing isoforms for MCEE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MCEE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAAGTTCA
    MCEE Expression
    About this image


    See MCEE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MCEE

    SOURCE GeneReport for Unigene cluster: Hs.94949
        SABiosciences Expression via Pathway-Focused PCR Arrays including MCEE: 
              Fatty Acid Metabolism in human mouse rat
              Amino Acid Metabolism II in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCEE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MCEE gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mcee1 , 5 methylmalonyl CoA epimerase1, 5 83.14(n)1
    80.11(a)1
      7 (34.65 cM)5
    737241  NM_028626.11  NP_082902.11 
     643926455 
    chicken
    (Gallus gallus)
    Aves MCEE1 methylmalonyl CoA epimerase 69.94(n)
    70.52(a)
      415385  XM_413770.3  XP_413770.1 
    lizard
    (Anolis carolinensis)
    Reptilia MCEE6
    Uncharacterized protein
    66(a)
    1 ↔ 1
    GL343428.1(12266-17472)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.114552 Xenopus laevis transcribed sequence with weak similarity more 74.25(n)    AW641355.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mcee1 methylmalonyl CoA epimerase 69.48(n)
    76.62(a)
      553804  NM_001020766.1  NP_001018602.1 
    worm
    (Caenorhabditis elegans)
    Secernentea D2030.53
    mce-11
    B.subtilis YQJC protein like3
    Protein MCE-11
    70(a)3
    64.87(n)1
    70.77(a)1
      I(7589938-7591115)3
    1725141  NM_059719.21  NP_492120.11 


    ENSEMBL Gene Tree for MCEE (if available)
    TreeFam Gene Tree for MCEE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/477 SNPs in MCEE are shown (see all 477)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1110335381,2
    C,Fpathogenic171217546(-) TGGGTC/TGACTC 2 R * stg12Minor allele frequency- T:0.00NA EU 5829
    rs729035461,2
    C--71202354(+) ACCATA/GAGCAT 1 -- ds50012Minor allele frequency- G:0.10WA 120
    rs1155517291,2
    F--71202367(+) TGGCAG/CTGGAT 1 -- ds50011Minor allele frequency- C:0.01NA 120
    rs1433878981,2
    C--71202399(+) CCCTAA/GGACCT 1 -- ds50010--------
    rs1833283951,2
    --71202524(+) CTTCCA/TATACA 1 -- ds50010--------
    rs729035481,2
    C--71202611(+) GAGATT/CAAAAT 1 -- ds50012Minor allele frequency- C:0.15WA 120
    rs1880672041,2
    --71202644(+) TCTAAA/GAAAGT 1 -- ds50010--------
    rs1512068121,2
    --71202702(+) ATTGTC/TATACT 1 -- ds50010--------
    rs1920608851,2
    --71202757(+) TACACA/CGCTAA 1 -- ds50010--------
    rs729035511,2
    C,F--71202771(+) ATTACA/TTTCAA 1 -- ds50012Minor allele frequency- T:0.09WA 120

    HapMap Linkage Disequilibrium report for MCEE (71336806 - 71357394 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for MCEE (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2720185CNV Deletion23290073
    nsv436287CNV Deletion17901297
    esv2678453CNV Deletion23128226
    esv2662403CNV Deletion23128226
    esv2675733CNV Deletion23128226
    nsv498925CNV Loss21111241
    nsv818028CNV Loss17921354
    nsv10002CNV Loss18304495
    nsv514075CNV Loss21397061
    nsv874254CNV Loss21882294


    Human Gene Mutation Database (HGMD): MCEE

    Locus Specific Mutation Databases (LSDB): MCEE
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608419   
    OMIM disorders: 251120  
    UniProtKB/Swiss-Prot: MCEE_HUMAN, Q96PE7
  • Methylmalonyl-CoA epimerase deficiency (MCEED) [MIM:251120]: Autosomal recessive inborn error of amino
    acid metabolism, involving valine, threonine, isoleucine and methionine. This organic aciduria may present in the
    neonatal period with life-threatening metabolic acidosis, hyperammonemia, feeding difficulties, pancytopenia and
    coma. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 5 diseases for MCEE:    About MalaCards
    mcee-related methylmalonic acidemia    methylmalonic acidemia    pancytopenia    metabolic acidosis
    tuberculosis

    1 disease from the University of Copenhagen DISEASES database for MCEE:
    Methylmalonic acidemia

    MCEE for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for MCEE gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methylmalonic aciduria 87.9 6 16697227 (2), 16752391 (1), 16843692 (1), 17823972 (1)

    GeneTests: MCEE
    GeneReviews: MCEE
    Genetic Association Database (GAD): MCEE
    Human Genome Epidemiology (HuGE) Navigator: MCEE (1 document)

    Export disorders for MCEE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MCEE gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with MCEE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A homozygous nonsense mutation in the methylmalonyl-CoA epimerase gene (MCEE) results in mild methylmalonic aciduria. (PubMed id 16752391)1, 2, 3, 9 Bikker H.... Duran M. (2006)
    2. Homozygous nonsense mutation in the MCEE gene and siRNA suppression of methylmalonyl-CoA epimerase expression: a novel cause of mild methylmalonic aciduria. (PubMed id 16697227)1, 3, 9 Dobson C.M....Gravel R.A. (2006)
    3. Propionyl-CoA and adenosylcobalamin metabolism in Cae norhabditis elegans: evidence for a role of methylmalonyl-CoA epimerase in inte rmediary metabolism. (PubMed id 16843692)1, 3, 9 Chandler R.J....Venditti C.P. (2006)
    4. Identification of the human methylmalonyl-CoA racemase gene based on the analysis of prokaryotic gene arrangements. Implications for decoding the human genome. (PubMed id 11481338)1, 2, 9 Bobik T.A. and Rasche M.E. (2001)
    5. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Atypical methylmalonic aciduria: frequency of mutations in the methylmalonyl CoA epimerase gene (MCEE). (PubMed id 17823972)1, 9 Gradinger A.B....Rosenblatt D.S. (2007)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84693 HGNC: 16732 AceView: MCEE Ensembl:ENSG00000124370 euGenes: HUgn84693
    ECgene: MCEE Kegg: 84693 H-InvDB: MCEE

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MCEE Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MCEE gene:
    Search GeneIP for patents involving MCEE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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