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Aliases for MCCD1 Gene

Aliases for MCCD1 Gene

  • Mitochondrial Coiled-Coil Domain 1 2 3

External Ids for MCCD1 Gene

Previous GeneCards Identifiers for MCCD1 Gene

  • GC00U913796
  • GC06U900561
  • GC06P031605
  • GC06P031496
  • GC06P031283

Summaries for MCCD1 Gene

GeneCards Summary for MCCD1 Gene

MCCD1 (Mitochondrial Coiled-Coil Domain 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCCD1 Gene

Genomics for MCCD1 Gene

Regulatory Elements for MCCD1 Gene

Genomic Location for MCCD1 Gene

31,528,717 bp from pter
31,530,232 bp from pter
1,516 bases
Plus strand

Genomic View for MCCD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCCD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MCCD1 Gene

  • Protein details for MCCD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial coiled-coil domain protein 1
    Protein Accession:
    Secondary Accessions:
    • A2AB29
    • A2RUP7
    • B0UZB2
    • Q7RTY2

    Protein attributes for MCCD1 Gene

    119 amino acids
    Molecular mass:
    13259 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MCCD1 Gene

Proteomics data for MCCD1 Gene at MOPED

Post-translational modifications for MCCD1 Gene

No Post-translational modifications

Other Protein References for MCCD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MCCD1 Gene

Domains for MCCD1 Gene

Protein Domains for MCCD1 Gene


Suggested Antigen Peptide Sequences for MCCD1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MCCD1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MCCD1 Gene

Function for MCCD1 Gene

Phenotypes for MCCD1 Gene

GenomeRNAi human phenotypes for MCCD1:
genes like me logo Genes that share phenotypes with MCCD1: view

Animal Model Products

CRISPR Products

miRNA for MCCD1 Gene

miRTarBase miRNAs that target MCCD1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for MCCD1 Gene

Localization for MCCD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCCD1 Gene


Subcellular locations from

Jensen Localization Image for MCCD1 Gene COMPARTMENTS Subcellular localization image for MCCD1 gene
Compartment Confidence
mitochondrion 5
extracellular 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MCCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with MCCD1: view

Pathways for MCCD1 Gene

SuperPathways for MCCD1 Gene

No Data Available

Interacting Proteins for MCCD1 Gene

Gene Ontology (GO) - Biological Process for MCCD1 Gene


No data available for Pathways by source for MCCD1 Gene

Transcripts for MCCD1 Gene

mRNA/cDNA for MCCD1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MCCD1 Gene

Mitochondrial coiled-coil domain 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MCCD1 Gene

No ASD Table

Relevant External Links for MCCD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MCCD1 Gene

mRNA expression in normal human tissues for MCCD1 Gene

mRNA differential expression in normal tissues according to GTEx for MCCD1 Gene

This gene is overexpressed in Kidney - Cortex (52.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MCCD1 Gene

SOURCE GeneReport for Unigene cluster for MCCD1 Gene Hs.558922

mRNA Expression by UniProt/SwissProt for MCCD1 Gene

Tissue specificity: Widely expressed. Expressed in adult and fetal liver, kidney and lung. Expressed in fetal brain. Weakly expressed in fetal spleen.
genes like me logo Genes that share expressions with MCCD1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Expression partners for MCCD1 Gene

Orthologs for MCCD1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MCCD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MCCD1 35
  • 77.06 (n)
  • 69.72 (a)
MCCD1 36
  • 68 (a)
(Canis familiaris)
Mammalia MCCD1 35
  • 81.03 (n)
  • 75.86 (a)
MCCD1 36
  • 80 (a)
(Pan troglodytes)
Mammalia MCCD1 35
  • 99.16 (n)
  • 99.16 (a)
MCCD1 36
  • 99 (a)
(Monodelphis domestica)
Mammalia MCCD1 36
  • 71 (a)
Species with no ortholog for MCCD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MCCD1 Gene

Gene Tree for MCCD1 (if available)
Gene Tree for MCCD1 (if available)

Paralogs for MCCD1 Gene Pseudogenes for MCCD1 Gene

genes like me logo Genes that share paralogs with MCCD1: view

No data available for Paralogs for MCCD1 Gene

Variants for MCCD1 Gene

Sequence variations from dbSNP and Humsavar for MCCD1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2259435 - 31,529,138(-) CTGCT(C/T)TTCCA missense, reference
rs2286712 -- 31,529,202(-) TCCTA(C/G)CTGTG intron-variant
rs2516480 -- 31,529,014(-) ACCAT(C/G)GCGGG utr-variant-5-prime
rs2516481 -- 31,528,946(-) AGGAC(A/T)TGGCC upstream-variant-2KB
rs2516482 -- 31,528,792(-) CAGTT(C/T)AGGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MCCD1 Gene

Variant ID Type Subtype PubMed ID
esv690 CNV CNV 17122850
dgv1042e201 CNV Deletion 23290073
dgv1921e1 CNV Complex 17122850
dgv213e55 CNV Gain 17911159
essv13266 CNV CNV 17122850
dgv6580n71 CNV Gain 21882294
dgv1927e1 CNV Complex 17122850
nsv884416 CNV Gain 21882294
nsv830627 CNV Loss 17160897
nsv526235 CNV Loss 19592680
nsv470809 CNV Loss 18288195

Relevant External Links for MCCD1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCCD1 Gene

Disorders for MCCD1 Gene

Relevant External Links for MCCD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MCCD1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MCCD1 Gene

Publications for MCCD1 Gene

  1. A novel gene encoding a coiled-coil mitochondrial protein located at the telomeric end of the human MHC Class III region. (PMID: 14527716) Semple J.I. … Campbell R.D. (Gene 2003) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). (PMID: 19115949) Limou S. … Zagury J.F. (J. Infect. Dis. 2009) 3 48
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for MCCD1 Gene

Sources for MCCD1 Gene

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