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Aliases for MCC Gene

Aliases for MCC Gene

  • Mutated In Colorectal Cancers 2 3
  • Colorectal Mutant Cancer Protein 3
  • Protein MCC 4
  • MCC1 3

External Ids for MCC Gene

Previous GeneCards Identifiers for MCC Gene

  • GC05M111957
  • GC05M112808
  • GC05M112392
  • GC05M112437
  • GC05M112434
  • GC05M112388
  • GC05M107537

Summaries for MCC Gene

Entrez Gene Summary for MCC Gene

  • This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MCC Gene

MCC (Mutated In Colorectal Cancers) is a Protein Coding gene. Diseases associated with MCC include colorectal cancer. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include receptor activity. An important paralog of this gene is USHBP1.

UniProtKB/Swiss-Prot for MCC Gene

  • Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation.

Gene Wiki entry for MCC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCC Gene

Genomics for MCC Gene

Regulatory Elements for MCC Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MCC Gene

Start:
113,022,099 bp from pter
End:
113,488,830 bp from pter
Size:
466,732 bases
Orientation:
Minus strand

Genomic View for MCC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCC Gene

Proteins for MCC Gene

  • Protein details for MCC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23508-CRCM_HUMAN
    Recommended name:
    Colorectal mutant cancer protein
    Protein Accession:
    P23508
    Secondary Accessions:
    • D3DT05
    • Q6ZR04

    Protein attributes for MCC Gene

    Size:
    829 amino acids
    Molecular mass:
    93027 Da
    Quaternary structure:
    • Interacts with SCRIB (via phosphorylated PDZ-binding motif), EZR, SNX27, SLC9A3R1 and SLC9A3R2. Interacts with CTNNB1; the interaction is enhanced upon Wnt stimulation. Interacts with MYH10.

    Alternative splice isoforms for MCC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCC Gene

Proteomics data for MCC Gene at MOPED

Post-translational modifications for MCC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MCC Gene

No data available for DME Specific Peptides for MCC Gene

Domains for MCC Gene

Gene Families for MCC Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for MCC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MCC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P23508

UniProtKB/Swiss-Prot:

CRCM_HUMAN :
  • P23508
Family:
  • Belongs to the MCC family.
genes like me logo Genes that share domains with MCC: view

Function for MCC Gene

Molecular function for MCC Gene

GENATLAS Biochemistry: mutated in colorectal cancer (see TSG5A)
UniProtKB/Swiss-Prot Function: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation.

Gene Ontology (GO) - Molecular Function for MCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0004872 receptor activity TAS 1848370
GO:0005509 calcium ion binding --
GO:0005515 protein binding IPI 18591935
genes like me logo Genes that share ontologies with MCC: view

Phenotypes for MCC Gene

MGI mutant phenotypes for MCC:
inferred from 2 alleles
GenomeRNAi human phenotypes for MCC:
genes like me logo Genes that share phenotypes with MCC: view

Animal Model Products

CRISPR Products

miRNA for MCC Gene

miRTarBase miRNAs that target MCC

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MCC

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MCC Gene

Localization for MCC Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCC Gene

Cell membrane. Cell projection, lamellipodium. Nucleus. Cytoplasm. Note=Colocalizes with actin at the leading edge of polarized cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCC Gene COMPARTMENTS Subcellular localization image for MCC gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18591935
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA 19555689
GO:0030027 lamellipodium IEA --
genes like me logo Genes that share ontologies with MCC: view

Pathways for MCC Gene

genes like me logo Genes that share pathways with MCC: view

Pathways by source for MCC Gene

1 BioSystems pathway for MCC Gene

Gene Ontology (GO) - Biological Process for MCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 1848370
GO:0010633 negative regulation of epithelial cell migration IMP 19555689
GO:0016055 Wnt signaling pathway IEA --
GO:0045184 establishment of protein localization IDA 18591935
GO:0050680 negative regulation of epithelial cell proliferation IDA 18591935
genes like me logo Genes that share ontologies with MCC: view

Transcripts for MCC Gene

Unigene Clusters for MCC Gene

Mutated in colorectal cancers:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MCC

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCC Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for MCC Gene

GeneLoc Exon Structure for
MCC
ECgene alternative splicing isoforms for
MCC

Expression for MCC Gene

mRNA expression in normal human tissues for MCC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MCC Gene

This gene is overexpressed in Ovary (8.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCC Gene

SOURCE GeneReport for Unigene cluster for MCC Gene Hs.593171

mRNA Expression by UniProt/SwissProt for MCC Gene

P23508-CRCM_HUMAN
Tissue specificity: Expressed in a variety of tissues
genes like me logo Genes that share expressions with MCC: view

In Situ Assay Products

Orthologs for MCC Gene

This gene was present in the common ancestor of animals.

Orthologs for MCC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCC 35
  • 99.3 (n)
  • 100 (a)
MCC 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MCC 35
  • 89.79 (n)
  • 96.91 (a)
MCC 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCC 35
  • 91.48 (n)
  • 97.9 (a)
MCC 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcc 35
  • 88.27 (n)
  • 95.65 (a)
Mcc 16
Mcc 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCC 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCC 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcc 35
  • 87.36 (n)
  • 94.54 (a)
chicken
(Gallus gallus)
Aves MCC 35
  • 79.7 (n)
  • 93.71 (a)
MCC 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCC 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mcc 35
  • 78.33 (n)
  • 92.2 (a)
zebrafish
(Danio rerio)
Actinopterygii mcc 35
  • 76.26 (n)
  • 84.9 (a)
MCC 36
  • 83 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG34404 36
  • 23 (a)
OneToMany
Species with no ortholog for MCC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MCC Gene

ENSEMBL:
Gene Tree for MCC (if available)
TreeFam:
Gene Tree for MCC (if available)

Paralogs for MCC Gene

Paralogs for MCC Gene

Selected SIMAP similar genes for MCC Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MCC: view

Variants for MCC Gene

Sequence variations from dbSNP and Humsavar for MCC Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs26959 -- 113,400,918(-) AGAGC(C/T)ACTTA intron-variant
rs26960 -- 113,401,041(-) TTAGG(C/T)CTCTT intron-variant
rs26961 -- 113,401,082(-) GTTCA(C/T)TTCCC intron-variant
rs26962 -- 113,401,313(-) TAATT(G/T)TAAGT intron-variant
rs26963 -- 113,402,273(-) tctgt(C/T)gccca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCC Gene

Variant ID Type Subtype PubMed ID
nsv882717 CNV Loss 21882294
nsv509990 CNV Loss 20534489
esv26027 CNV Gain 19812545
nsv516887 CNV Loss 19592680
nsv528441 CNV Loss 19592680
esv2730602 CNV Deletion 23290073
esv2730603 CNV Deletion 23290073
esv22346 CNV Loss 19812545
esv2666148 CNV Deletion 23128226
nsv329870 CNV Loss 16902084
esv1010186 CNV Insertion 20482838
nsv512858 CNV Insertion 21212237
esv1419638 CNV Insertion 17803354
nsv882718 CNV Loss 21882294
nsv882719 CNV Loss 21882294
nsv471785 CNV Loss 16327809
nsv528805 CNV Loss 19592680
esv2660679 CNV Deletion 23128226
esv25166 CNV Loss 19812545
esv1715529 CNV Insertion 17803354
esv1680514 CNV Insertion 17803354
esv2671074 CNV Deletion 23128226
nsv329948 CNV Loss 16902084
esv2669481 CNV Deletion 23128226

Relevant External Links for MCC Gene

HapMap Linkage Disequilibrium report
MCC
Human Gene Mutation Database (HGMD)
MCC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCC Gene

Disorders for MCC Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MCC Gene including...

Search for MCC Gene in MalaCards »

(1) OMIM Diseases for MCC Gene (159350)

(1) University of Copenhagen DISEASES for MCC Gene

(9) Novoseek inferred disease relationships for MCC Gene

Disease -log(P) Hits PubMed IDs
familial adenomatous polyposis 76.4 4
colorectal tumors 75.3 6
colorectal carcinoma 52.5 3
colorectal cancer 52.1 5
nsclc 44.1 1

Relevant External Links for MCC

Genetic Association Database (GAD)
MCC
Human Genome Epidemiology (HuGE) Navigator
MCC
Tumor Gene Database (TGDB):
MCC
genes like me logo Genes that share disorders with MCC: view

No data available for UniProtKB/Swiss-Prot for MCC Gene

Publications for MCC Gene

  1. Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. (PMID: 1848370) Kinzler K.W. … Nakamura Y. (Science 1991) 2 3 4 23
  2. MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase. (PMID: 8626604) Matsumine A. … Akiyama T. (J. Biol. Chem. 1996) 3 23
  3. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. (PMID: 1651563) Nishisho I. … Vogelstein B. (Science 1991) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin- dependent transcription. (PMID: 18591935) Fukuyama R. … Sizemore N. (Oncogene 2008) 3 4

Products for MCC Gene

Sources for MCC Gene

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