Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MCC Gene

protein-coding GIFtS: 59
GCID: GC05M112388

mutated in colorectal cancers

Explore 19 diseases affiliated with
MCC via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mutated In Colorectal Cancers¹ ²
MCC1²
Colorectal Mutant Cancer Protein²
Protein MCC³

External Ids:	HGNC: 6935¹	Entrez Gene: 4163²	Ensembl: ENSG00000171444⁷	OMIM: 159350⁵	UniProtKB: P23508³

Export aliases for MCC gene to outside databases

Previous GC identifers: GC05M111957 GC05M112808 GC05M112392 GC05M112437 GC05M112434 GC05M107537

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MCC:

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle

progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and

membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants

encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CRCM_HUMAN, P23508

Function: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation

and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription

factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation

Gene Wiki entry for MCC

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MCC gene promoter:
RP58 Sp1 Pax-5 HOXA3 AML1a MEF-2A aMEF-2 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): MCC promoter sequence

Search SABiosciences Chromatin IP Primers for MCC

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCC

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q21 Ensembl cytogenetic band: 5q22.2 HGNC cytogenetic band: 5q21-q22

MCC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCC gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M112388: view genomic region (about GC identifiers)

Start:	112,357,796 bp from pter	End:	112,824,527 bp from pter
Size:	466,732 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CRCM_HUMAN, P23508 (See protein sequence)

Recommended Name: Colorectal mutant cancer protein

Size: 829 amino acids; 93027 Da

Subunit: Interacts with SCRIB, EZR, SNX27, SLC9A3R1 and SLC9A3R2. Interacts with CTNNB1; the interaction is enhanced

upon Wnt stimulation

Subcellular location: Cell membrane. Nucleus. Cytoplasm

Secondary accessions: D3DT05 Q6ZR04

Alternative splicing: 2 isoforms: P23508-1 P23508-2 (Ref.5 (BAC87521) sequence is in conflict in position: 25:S->GSSSG)

Explore the universe of human proteins at neXtProt for MCC: NX_P23508

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P23508

MCC Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001078846.1 NP_002378.1

ENSEMBL proteins:

ENSP00000305617 ENSP00000421615 ENSP00000386227

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: MCC Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for MCC
	GenScript Custom Purified and Recombinant Proteins Services for MCC
	Novus Biologicals MCC Proteins Novus Biologicals MCC Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MCC

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18591935
GO:0005737	cytoplasm	IDA	--
GO:0005886	plasma membrane	IDA	19555689

MCC for ontologies About GeneDecksing

MCC Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for MCC
	GenScript Custom Superior Antibodies Services for MCC
	Novus Biologicals MCC Antibodies
	Search for Antibodies for MCC at Abcam
	Uscn Antibodies for MCC
	Search ThermoFisher Antibodies for MCC

Assay Products for MCC:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MCC
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MCC

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MCC for domains About GeneDecksing

1 InterPro domain/family:

IPR019536 USH1C-bd_PDZ_domain

Graphical View of Domain Structure for InterPro Entry P23508

ProtoNet protein and cluster: P23508

UniProtKB/Swiss-Prot: CRCM_HUMAN, P23508

Similarity: Belongs to the MCC family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CRCM_HUMAN, P23508

Function: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation

and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription

factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation

Genatlas biochemistry entry for MCC:

mutated in colorectal cancer (see TSG5A)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MCC Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCC
		8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate MCC (see all 74):
		hsa-miR-548j hsa-miR-300 hsa-miR-106a hsa-miR-3074-3p hsa-miR-519a hsa-miR-93 hsa-miR-548a-5p hsa-miR-200b

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCC (see all 4) OriGene shRNA RFP: MCC OriGene siRNA: MCC
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MCC

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MCC

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCC (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCC (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MCC (NM_002387)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCC
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCC

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MCC
		Search LifeMap BioReagents cell lines for MCC

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCC

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	TAS	1848370
GO:0005515	protein binding	IPI	--

MCC for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MCC:

Upregulation of Wnt/beta-caten

Animal Models:
1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Mcc):

normal

MCC for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TNF-alpha/NF-kB Signaling Pathway

TNF-alpha/NF-kB Signaling Pathway

1.00

1 BioSystems Pathway for MCC

TNF-alpha/NF-kB Signaling Pathway

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MCC

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/249 Interacting proteins for MCC (P23508^{1, 2, 3} ENSP00000386227⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 249)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SCRIB	Q14160²^,³, ENSP00000349486⁴	MINT-7210634 MINT-7210690 MINT-7210609 MINT-7210820 MINT-7211237 MINT-7211022 MINT-7210883 MINT-7210731 I2D: score=1 STRING: ENSP00000349486
CSNK1E	P49674²^,³, ENSP00000352929⁴	MINT-8252780 I2D: score=3 STRING: ENSP00000352929
EZR	P15311²^,³, ENSP00000338934⁴	MINT-7211237 I2D: score=2 STRING: ENSP00000338934
NFKBIB	Q15653²^,³	MINT-47859 I2D: score=4
DYNC1I1	O14576²^,³	MINT-8254888 I2D: score=2

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	1848370
GO:0010633	negative regulation of epithelial cell migration	IMP	19555689
GO:0016055	Wnt receptor signaling pathway	IEA	--
GO:0050680	negative regulation of epithelial cell proliferation	IDA	18591935
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	IDA	18591935

MCC for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MCC
Search CenterWatch for drugs/clinical trials and news about MCC / CRCM

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MCC gene (2 alternative transcripts):

NM_001085377.1 NM_002387.2

Unigene Cluster for MCC:

Mutated in colorectal cancers

Hs.593171 [show with all ESTs]

Unigene Representative Sequence: NM_001085377

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000302475(uc003kqj.4 uc003kqk.4 uc003kql.4) ENST00000515367

ENST00000408903 ENST00000514701(uc011cwb.1 uc010jcd.1) ENST00000502648

ENST00000505604 ENST00000506605 ENST00000511847 ENST00000511242

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MCC Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCC
		8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate MCC (see all 74):
		hsa-miR-548j hsa-miR-300 hsa-miR-106a hsa-miR-3074-3p hsa-miR-519a hsa-miR-93 hsa-miR-548a-5p hsa-miR-200b

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCC (see all 4) OriGene shRNA RFP: MCC OriGene siRNA: MCC
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MCC

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCC (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCC (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MCC (NM_002387)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCC
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCC

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MCC Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat MCC
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCC
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCC

Additional cDNA sequence:

AK096212.1 AK128596.1 AK300259.1 AL359558.1 BC009279.2 BC018919.2 BC043431.2 BX537952.1

CR749713.1 M62397.1

12 DOTS entries:

DT.441438 DT.439205 DT.206787 DT.99936084 DT.101982227 DT.120847212 DT.40210745 DT.92419764

DT.437378 DT.120847111 DT.92426124 DT.100800143

24/155 AceView cDNA sequences (see all 155):

CD515997 CA337225 CF890841 AW169982 CB305455 BM665160 BM313537 AV661084

AA018666 AV645467 BX109864 CB051013 N50795 BM695282 BU737797 BX503916

BE880871 AA937337 AL359558 BG618915 AK096212 AK128596 AI125954 BX280605

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for MCC About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16	^	17	^	18a	·	18b
SP1:																	-
SP2:					-												-
SP3:					-		-										-
SP4:

ECgene alternative splicing isoforms for MCC

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MCC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGACTAAGTT

About this image

MCC expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Primitive streak-like cells (Generation of endode...)

Extraembryonic endoderm-like cells (Generation of extrae...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MCC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MCC

SOURCE GeneReport for Unigene cluster: Hs.593171

UniProtKB/Swiss-Prot: CRCM_HUMAN, P23508

Tissue specificity: Expressed in a variety of tissues

SABiosciences Custom PCR Arrays for MCC

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MCC Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat MCC
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCC
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCC

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MCC gene from 5/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mcc^{1 , 5}	mutated in colorectal cancers^{1, 5}	88.02(n)¹ 95.31(a)¹		18 (23.74 cM)⁵ 328949¹ NM_001085373.1¹ NP_001078842.1¹ 44425061⁵
chicken (Gallus gallus)	Aves	MCC¹	mutated in colorectal cancers	79.59(n) 93.22(a)		415603 XM_413971.3 XP_413971.3
lizard (Anolis carolinensis)	Reptilia	MCC⁶	--	92(a)	1 ↔ 1	GL343193.1(7084892-7178820)
zebrafish (Danio rerio)	Actinopterygii	mcc¹	mutated in colorectal cancers	76.36(n) 85.01(a)		100537329 XM_003198564.1 XP_003198612.1
fruit fly (Drosophila melanogaster)	Insecta	CG34404¹	CG34404	44.27(n) 31.49(a)		41873 NM_142200.3 NP_650457.2

ENSEMBL Gene Tree for MCC (if available)
TreeFam Gene Tree for MCC (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MCC gene

USHBP1²

1 SIMAP similar gene for MCC using alignment to 2 protein entries: CRCM_HUMAN (see all proteins):

DKFZp686J1286

MCC for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74342408^1,2	C,	--	107537136(+)	`GTCAA-/GGTTAC`	2	--	ds500¹		0	--	--	--	--
rs76268784^1,2	C,F,	--	107537500(+)	`GGATAG/ACCTTA`	2	--	ds500¹		2		WA EA	238
rs11552010^1,2	F,	--	107538544(-)	`ATAATA/C/GCTGAC`	4	--	ut3¹		1		WA	118
rs79070394^1,2	F,	--	107538958(+)	`GTACCC/ATAATT`	2	--	ut3¹		1		WA	118
rs113312294^1,2		--	107539048(+)	`TTTGCC/TGAATC`	2	--	ut3¹		1		CSA	2
rs111392734^1,2	F,	--	107539245(+)	`TTGACA/G/TGATAG`	4	--	ut3¹		3		CSA WA	122
rs74382553^1,2	F,	--	107539369(+)	`TTGATC/TGGGTA`	2	--	ut3¹		1		NA	120
rs79192921^1,2	F,	--	107539382(+)	`TACGGT/CGCACT`	2	--	ut3¹		1		WA	118
rs201014205^1,2	C	--	107539478(+)	`ACTTTC/TTTTAC`	2	--	ut3¹		0	--	--	--	--
rs6862944^1,2	C,F,A,H,	--	107539776(+)	`GACAGA/GTTTTT`	2	--	ut3¹		6		NS EA WA NA	656

HapMap Linkage Disequilibrium report for MCC (112357796 - 112607796 bp, first 250kb of MCC)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for MCC
6 CNVs: 93190 64281 6437 51529 23748 69185
4 Indels: 10894 12736 64279 40792

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MCC

DNA2.0 Custom Variant and Variant Library Synthesis for MCC

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MCC for disorders           About GeneDecksing

OMIM gene information: 159350    OMIM disorders: --

19 diseases for MCC:    About MalaCards

colorectal cancer familial adenomatous polyposis adenomatous polyposis coli nonpapillary renal cell carcinoma

pleuropneumonia merkel cell carcinoma polyposis atopic dermatitis

renal cell carcinoma pandas dermatitis esophageal cancer

esophagitis gastric cancer pancreatic cancer lung cancer

carcinoma breast cancer pancreatitis

1 disease from the University of Copenhagen DISEASES database for MCC:

Nonpapillary renal cell carcinoma

9 Novoseek disease relationships for MCC gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
familial adenomatous polyposis	76.4	4	1565631 (2), 1325652 (2)
colorectal tumors	75.3	7	1848370 (2), 8626604 (2), 1651562 (1), 1682292 (1)
colorectal carcinoma	52.5	3	1682292 (2), 1325652 (1)
colorectal cancer	52.1	5	1848370 (1), 1668888 (1), 1682292 (1), 1339098 (1) (see all 5)
nsclc	44.1	2	7812947 (1)
colon cancer	33.3	4	1565631 (2), 1314630 (1), 11311560 (1)
tumors	25.9	10	11311560 (2), 7796415 (1), 8226275 (1), 7812947 (1) (see all 8)
cancer lung	21.9	2	1565631 (1), 1348017 (1)
cancer	3.24	2	1565631 (2)

Human Genome Epidemiology (HuGE) Navigator: MCC (9 documents)
Tumor Gene Database (TGDB): MCC

Export disorders for MCC gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MCC gene, integrated from 9 sources (see all 52):
(articles sorted by number of sources associating them with MCC)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. (PubMed id 1848370)^{1, 2, 3, 9} Kinzler K.W.... Nakamura Y. (1991)
MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells. (PubMed id 19555689)^{1, 2} Arnaud C....Lecine P. (2009)
Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin- dependent transcription. (PubMed id 18591935)^{1, 2} Fukuyama R.... Sizemore N. (2008)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. (PubMed id 1651563)^{1, 2} Nishisho I....Hedge P. (1991)
MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase. (PubMed id 8626604)^{1, 9} Matsumine A....Akiyama T. (1996)
Loss of heterozygosity of the Mutated in Colorectal Ca ncer gene is not associated with promoter methylation in non-small cell lung can cer. (PubMed id 22542170)¹ Poursoltan P....Kohonen-Corish M.R. (2012)
The PDZ-binding motif of MCC is phosphorylated at posi tion -1 and controls lamellipodia formation in colon epithelial cells. (PubMed id 22480440)¹ Pangon L....Kohonen-Corish M.R. (2012)
Mutated in colorectal cancer protein modulates the NFk B pathway. (PubMed id 22213290)¹ Sigglekow N.D....Kohonen-Corish M.R. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4163	HGNC: 6935	AceView: MCC	Ensembl:ENSG00000171444	euGenes: HUgn4163
ECgene: MCC	H-InvDB: MCC

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MCC	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MCC	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MCC gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MCC gene:
Search GeneIP for patents involving MCC

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for MCC
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCC		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MCC
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for MCC		OriGene 3'-UTR Clone for MCC
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MCC		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MCC
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for MCC		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MCC		OriGene Custom Protein Services for MCC
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MCC
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MCC
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCC
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MCC
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCC
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCC

	GenScript Custom Purified and Recombinant Proteins Services for MCC		GenScript cDNA clones with any tag delivered in your preferred vector for MCC
	GenScript Custom Assay Services for MCC		GenScript Custom Superior Antibodies Services for MCC
	GenScript Custom overexpressing Cell Line Services for MCC		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in MCC promoter
	Search Chromatin IP Primers for MCC
	RT² qPCR Primer Assay in human, mouse / rat MCC
	GNC Network for MCC
	SABiosciences Custom PCR Arrays for MCC

Search Tocris compounds for MCC

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	MCC antibodies
	MCC proteins
	MCC lysates

	Search for Antibodies for MCC at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for MCC
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

MCC Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for MCC

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCC

	Browse SwitchGear 3'UTR luciferase reporter plasmids for MCC
	SwitchGear Promoter luciferase reporter plasmids for MCC

Search ThermoFisher Antibodies for MCC

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCC

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MCC gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

MCC Gene

mutated in colorectal cancers

Aliases
for MCC gene

Summaries
for MCC gene

Genomic Views
for MCC gene

Proteins
for MCC gene

Protein Domains /
Families
for MCC gene

Function
for MCC gene

Pathways & Interactions
for MCC gene

Drugs & Compounds
for MCC gene

Transcripts
for MCC gene

Expression
for MCC gene

Orthologs
for MCC gene

Paralogs
for MCC gene

Genomic Variants
for MCC gene

Disorders / Diseases
for MCC gene

Publications
for MCC gene

External Searches for MCC gene

Genome Databases showing MCC gene

Other Databases showing MCC gene

Specialized Databases showing MCC gene

Intellectual Property
for MCC gene

Products
for MCC gene

View Random Gene

Advanced Search

Export list of displayed genes

MCC Gene

mutated in colorectal cancers

Aliasesfor MCC gene

Summariesfor MCC gene

Genomic Viewsfor MCC gene

Proteinsfor MCC gene

Protein Domains /Familiesfor MCC gene

Functionfor MCC gene

Pathways & Interactionsfor MCC gene

Drugs & Compoundsfor MCC gene

Transcriptsfor MCC gene

Expression for MCC gene

Orthologsfor MCC gene

Paralogsfor MCC gene

Genomic Variantsfor MCC gene

Disorders / Diseasesfor MCC gene

Publicationsfor MCC gene

External Searches for MCC gene

Genome Databases showing MCC gene

Other Databases showing MCC gene

Specialized Databases showing MCC gene

Intellectual Propertyfor MCC gene

Productsfor MCC gene

View Random Gene

Aliases
for MCC gene

Summaries
for MCC gene

Genomic Views
for MCC gene

Proteins
for MCC gene

Protein Domains /
Families
for MCC gene

Function
for MCC gene

Pathways & Interactions
for MCC gene

Drugs & Compounds
for MCC gene

Transcripts
for MCC gene

Expression
for MCC gene

Orthologs
for MCC gene

Paralogs
for MCC gene

Genomic Variants
for MCC gene

Disorders / Diseases
for MCC gene

Publications
for MCC gene

Intellectual Property
for MCC gene

Products
for MCC gene