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Aliases for MCC Gene

Aliases for MCC Gene

  • Mutated In Colorectal Cancers 2 3 5
  • Protein MCC 4
  • MCC1 3

External Ids for MCC Gene

Previous GeneCards Identifiers for MCC Gene

  • GC05M111957
  • GC05M112808
  • GC05M112392
  • GC05M112437
  • GC05M112434
  • GC05M112388
  • GC05M107537

Summaries for MCC Gene

Entrez Gene Summary for MCC Gene

  • This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MCC Gene

MCC (Mutated In Colorectal Cancers) is a Protein Coding gene. Diseases associated with MCC include Colorectal Cancer and Familial Adenomatous Polyposis. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include calcium ion binding and receptor activity. An important paralog of this gene is USHBP1.

UniProtKB/Swiss-Prot for MCC Gene

  • Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780).

Gene Wiki entry for MCC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCC Gene

Genomics for MCC Gene

Regulatory Elements for MCC Gene

Enhancers for MCC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MCC on UCSC Golden Path with GeneCards custom track

Promoters for MCC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MCC on UCSC Golden Path with GeneCards custom track

Genomic Location for MCC Gene

Chromosome:
5
Start:
113,022,099 bp from pter
End:
113,488,830 bp from pter
Size:
466,732 bases
Orientation:
Minus strand

Genomic View for MCC Gene

Genes around MCC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCC Gene

Proteins for MCC Gene

  • Protein details for MCC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23508-CRCM_HUMAN
    Recommended name:
    Colorectal mutant cancer protein
    Protein Accession:
    P23508
    Secondary Accessions:
    • D3DT05
    • Q6ZR04

    Protein attributes for MCC Gene

    Size:
    829 amino acids
    Molecular mass:
    93027 Da
    Quaternary structure:
    • Interacts with SCRIB (via phosphorylated PDZ-binding motif), EZR, SNX27, SLC9A3R1 and SLC9A3R2. Interacts with CTNNB1; the interaction is enhanced upon Wnt stimulation. Interacts with MYH10. Interacts with CCAR2.

    Alternative splice isoforms for MCC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCC Gene

Proteomics data for MCC Gene at MOPED

Post-translational modifications for MCC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MCC Gene

No data available for DME Specific Peptides for MCC Gene

Domains & Families for MCC Gene

Gene Families for MCC Gene

Protein Domains for MCC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MCC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P23508

UniProtKB/Swiss-Prot:

CRCM_HUMAN :
  • Belongs to the MCC family.
Family:
  • Belongs to the MCC family.
genes like me logo Genes that share domains with MCC: view

Function for MCC Gene

Molecular function for MCC Gene

GENATLAS Biochemistry:
mutated in colorectal cancer (see TSG5A)
UniProtKB/Swiss-Prot Function:
Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780).

Gene Ontology (GO) - Molecular Function for MCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 1848370
genes like me logo Genes that share ontologies with MCC: view
genes like me logo Genes that share phenotypes with MCC: view

Human Phenotype Ontology for MCC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for MCC Gene

miRTarBase miRNAs that target MCC

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MCC Gene

Localization for MCC Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCC Gene

Cell membrane. Cell projection, lamellipodium. Nucleus. Cytoplasm. Note=Colocalizes with actin at the leading edge of polarized cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCC Gene COMPARTMENTS Subcellular localization image for MCC gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 18591935
genes like me logo Genes that share ontologies with MCC: view

Pathways & Interactions for MCC Gene

genes like me logo Genes that share pathways with MCC: view

Pathways by source for MCC Gene

1 BioSystems pathway for MCC Gene

Gene Ontology (GO) - Biological Process for MCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 1848370
GO:0010633 negative regulation of epithelial cell migration IMP 19555689
GO:0045184 establishment of protein localization IDA 18591935
GO:0090090 negative regulation of canonical Wnt signaling pathway IMP 24824780
genes like me logo Genes that share ontologies with MCC: view

No data available for SIGNOR curated interactions for MCC Gene

Drugs & Compounds for MCC Gene

No Compound Related Data Available

Transcripts for MCC Gene

Unigene Clusters for MCC Gene

Mutated in colorectal cancers:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MCC Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for MCC Gene

GeneLoc Exon Structure for
MCC
ECgene alternative splicing isoforms for
MCC

Expression for MCC Gene

mRNA expression in normal human tissues for MCC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MCC Gene

This gene is overexpressed in Ovary (x8.1).

Protein differential expression in normal tissues from HIPED for MCC Gene

This gene is overexpressed in Ovary (14.7), Bone marrow stromal cell (11.6), Breast (11.1), Adrenal (8.5), and Retina (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCC Gene



SOURCE GeneReport for Unigene cluster for MCC Gene Hs.593171

mRNA Expression by UniProt/SwissProt for MCC Gene

P23508-CRCM_HUMAN
Tissue specificity: Expressed in a variety of tissues.
genes like me logo Genes that share expression patterns with MCC: view

Primer Products

No data available for Protein tissue co-expression partners for MCC Gene

Orthologs for MCC Gene

This gene was present in the common ancestor of animals.

Orthologs for MCC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MCC 35
  • 89.79 (n)
  • 96.91 (a)
MCC 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCC 35
  • 91.48 (n)
  • 97.9 (a)
MCC 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcc 35
  • 88.27 (n)
  • 95.65 (a)
Mcc 16
Mcc 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MCC 35
  • 99.3 (n)
  • 100 (a)
MCC 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcc 35
  • 87.36 (n)
  • 94.54 (a)
oppossum
(Monodelphis domestica)
Mammalia MCC 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCC 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves MCC 35
  • 79.7 (n)
  • 93.71 (a)
MCC 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCC 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mcc 35
  • 78.33 (n)
  • 92.2 (a)
zebrafish
(Danio rerio)
Actinopterygii mcc 35
  • 76.26 (n)
  • 84.9 (a)
MCC 36
  • 83 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG34404 36
  • 23 (a)
OneToMany
Species with no ortholog for MCC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MCC Gene

ENSEMBL:
Gene Tree for MCC (if available)
TreeFam:
Gene Tree for MCC (if available)

Paralogs for MCC Gene

Paralogs for MCC Gene

(1) SIMAP similar genes for MCC Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MCC: view

Variants for MCC Gene

Sequence variations from dbSNP and Humsavar for MCC Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_005141 A colorectal cancer sample
rs35269015 A colorectal cancer sample 113,068,082(-) CTCCC(C/T)TGGTA reference, missense
VAR_005143 A colorectal cancer sample
VAR_005144 Colorectal cancer samples
VAR_005145 Colorectal cancer samples

Structural Variations from Database of Genomic Variants (DGV) for MCC Gene

Variant ID Type Subtype PubMed ID
nsv882717 CNV Loss 21882294
nsv509990 CNV Loss 20534489
esv26027 CNV Gain 19812545
nsv516887 CNV Loss 19592680
nsv528441 CNV Loss 19592680
esv2730602 CNV Deletion 23290073
esv2730603 CNV Deletion 23290073
esv22346 CNV Loss 19812545
esv2666148 CNV Deletion 23128226
nsv329870 CNV Loss 16902084
esv1010186 CNV Insertion 20482838
nsv512858 CNV Insertion 21212237
esv1419638 CNV Insertion 17803354
nsv882718 CNV Loss 21882294
nsv882719 CNV Loss 21882294
nsv471785 CNV Loss 16327809
nsv528805 CNV Loss 19592680
esv2660679 CNV Deletion 23128226
esv25166 CNV Loss 19812545
esv1715529 CNV Insertion 17803354
esv1680514 CNV Insertion 17803354
esv2671074 CNV Deletion 23128226
nsv329948 CNV Loss 16902084
esv2669481 CNV Deletion 23128226

Variation tolerance for MCC Gene

Residual Variation Intolerance Score: 30.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.14; 90.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCC Gene

Human Gene Mutation Database (HGMD)
MCC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCC Gene

Disorders for MCC Gene

MalaCards: The human disease database

(2) MalaCards diseases for MCC Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
familial adenomatous polyposis
  • adenomatous polyposis coli
- elite association - COSMIC cancer census association via MalaCards
Search MCC in MalaCards View complete list of genes associated with diseases

Relevant External Links for MCC

Genetic Association Database (GAD)
MCC
Human Genome Epidemiology (HuGE) Navigator
MCC
Tumor Gene Database (TGDB):
MCC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCC
genes like me logo Genes that share disorders with MCC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MCC Gene

Publications for MCC Gene

  1. Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. (PMID: 1848370) Kinzler K.W. … Nakamura Y. (Science 1991) 2 3 4 23 67
  2. Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes. (PMID: 25200342) Edwards S.K. … Xie P. (J Hematol Oncol 2014) 2 3
  3. MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase. (PMID: 8626604) Matsumine A. … Akiyama T. (J. Biol. Chem. 1996) 3 23
  4. MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm. (PMID: 24824780) Pangon L. … Kohonen-Corish M.R. (Int. J. Cancer 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for MCC Gene

Sources for MCC Gene

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