External Ids for MCC Gene
Previous GeneCards Identifiers for MCC Gene
This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MCC Gene
MCC (Mutated In Colorectal Cancers) is a Protein Coding gene. Diseases associated with MCC include Colorectal Cancer and Familial Adenomatous Polyposis. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include calcium ion binding and receptor activity. An important paralog of this gene is USHBP1.
UniProtKB/Swiss-Prot for MCC Gene
Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780).