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Aliases for MCAT Gene

Aliases for MCAT Gene

  • Malonyl-CoA-Acyl Carrier Protein Transacylase 2 3 5
  • Malonyl CoA:ACP Acyltransferase (Mitochondrial) 2 3
  • Mitochondrial Malonyl CoA:ACP Acyltransferase 3 4
  • [Acyl-Carrier-Protein] S-Malonyltransferase 2 3
  • [Acyl-Carrier-Protein] Malonyltransferase 3 4
  • Mitochondrial Malonyltransferase 3 4
  • MCT 3 4
  • MT 3 4
  • Malonyl-CoA-Acyl Carrier Protein Transacylase, Mitochondrial 3
  • EC 2.3.1.39 4
  • FASN2C 3
  • NET62 3
  • FabD 3

External Ids for MCAT Gene

Previous GeneCards Identifiers for MCAT Gene

  • GC22M041858
  • GC22M043528
  • GC22M026486

Summaries for MCAT Gene

Entrez Gene Summary for MCAT Gene

  • The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2012]

GeneCards Summary for MCAT Gene

MCAT (Malonyl-CoA-Acyl Carrier Protein Transacylase) is a Protein Coding gene. Diseases associated with MCAT include Middle Ear Disease. Among its related pathways are Metabolism and Fatty acid metabolism. GO annotations related to this gene include poly(A) RNA binding and [acyl-carrier-protein] S-malonyltransferase activity.

UniProtKB/Swiss-Prot for MCAT Gene

  • Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondrias.

Gene Wiki entry for MCAT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCAT Gene

Genomics for MCAT Gene

Regulatory Elements for MCAT Gene

Enhancers for MCAT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F043103 1.6 FANTOM5 Ensembl ENCODE 12 +39.0 38977 1.6 PKNOX1 ATF1 MLX ARID4B GATA2 FOS JUNB MXD4 TSHZ1 REST MCAT TSPO CYB5R3 ARFGAP3 BIK CYP2D7 GC22M043099
GH22F043012 1.4 FANTOM5 ENCODE 10.5 +128.8 128807 3.2 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 PACSIN2 RPL5P34 ARFGAP3 NAGA MCAT PIR35633
GH22F042867 1.4 Ensembl ENCODE 10.1 +275.7 275696 1.0 PKNOX1 MLX ARNT WRNIP1 ARID4B ZNF2 YY1 SLC30A9 ZNF143 ZNF207 ARFGAP3 LOC100506679 MCAT ENSG00000227370 LOC101927393
GH22F043099 1.2 VISTA Ensembl ENCODE 11.7 +42.2 42231 2.6 ELF3 PKNOX1 SAP130 NR2F2 ARID1B GATA3 GATA2 ZNF157 PBX2 TCF7 LOC100506679 TSPO MCAT CYB5R3 ARFGAP3 BIK TTLL1 GC22M043099
GH22F043066 1.2 Ensembl ENCODE 10.9 +75.9 75895 1.4 PKNOX1 KLF17 ZNF2 ZEB1 GTF3C2 ZNF121 GLIS2 ZNF366 FOS CREM TTLL1 RPS25P10 RN7SKP80 BIK ENSG00000273366 A4GALT MCAT RPL5P34 ENSG00000233903 OGFRP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MCAT on UCSC Golden Path with GeneCards custom track

Promoters for MCAT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000170766 297 1801 HDGF MLX ARID4B SIN3A DMAP1 ZNF143 ZNF207 ZHX2 MXD4 REST

Genomic Location for MCAT Gene

Chromosome:
22
Start:
43,132,206 bp from pter
End:
43,143,397 bp from pter
Size:
11,192 bases
Orientation:
Minus strand

Genomic View for MCAT Gene

Genes around MCAT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCAT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCAT Gene

Proteins for MCAT Gene

  • Protein details for MCAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVS2-FABD_HUMAN
    Recommended name:
    Malonyl-CoA-acyl carrier protein transacylase, mitochondrial
    Protein Accession:
    Q8IVS2
    Secondary Accessions:
    • B0QY72
    • O95510
    • O95511

    Protein attributes for MCAT Gene

    Size:
    390 amino acids
    Molecular mass:
    42962 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MCAT Gene

    Alternative splice isoforms for MCAT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCAT Gene

Post-translational modifications for MCAT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MCAT Gene

No data available for DME Specific Peptides for MCAT Gene

Domains & Families for MCAT Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVS2

UniProtKB/Swiss-Prot:

FABD_HUMAN :
  • Belongs to the type II malonyltransferase family.
Family:
  • Belongs to the type II malonyltransferase family.
genes like me logo Genes that share domains with MCAT: view

No data available for Gene Families for MCAT Gene

Function for MCAT Gene

Molecular function for MCAT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].
UniProtKB/Swiss-Prot Function:
Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondrias.

Enzyme Numbers (IUBMB) for MCAT Gene

Gene Ontology (GO) - Molecular Function for MCAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity IEA,IDA 12882974
GO:0016740 transferase activity IEA,IDA 12882974
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MCAT: view
genes like me logo Genes that share phenotypes with MCAT: view

Animal Model Products

miRNA for MCAT Gene

miRTarBase miRNAs that target MCAT

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MCAT

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCAT Gene

Localization for MCAT Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCAT Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCAT gene
Compartment Confidence
mitochondrion 5
cytoskeleton 2
cytosol 2
plasma membrane 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MCAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 12882974
genes like me logo Genes that share ontologies with MCAT: view

Pathways & Interactions for MCAT Gene

genes like me logo Genes that share pathways with MCAT: view

UniProtKB/Swiss-Prot Q8IVS2-FABD_HUMAN

  • Pathway: Lipid metabolism; fatty acid biosynthesis.

Gene Ontology (GO) - Biological Process for MCAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0008152 metabolic process IEA,IDA 12882974
genes like me logo Genes that share ontologies with MCAT: view

No data available for SIGNOR curated interactions for MCAT Gene

Drugs & Compounds for MCAT Gene

(3) Drugs for MCAT Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
3,6,9,12,15-PENTAOXAHEPTADECAN-1-OL Experimental Pharma Target 0
malonyl-coa Experimental Pharma 0
Coenzyme A Nutra 0
genes like me logo Genes that share compounds with MCAT: view

Transcripts for MCAT Gene

Unigene Clusters for MCAT Gene

Malonyl CoA:ACP acyltransferase (mitochondrial):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MCAT

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCAT Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
SP1: - - -
SP2: - - - -
SP3: -
SP4: - - -
SP5: - -

Relevant External Links for MCAT Gene

GeneLoc Exon Structure for
MCAT
ECgene alternative splicing isoforms for
MCAT

Expression for MCAT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MCAT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MCAT Gene

This gene is overexpressed in Liver (18.4) and Lung (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MCAT Gene



Protein tissue co-expression partners for MCAT Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MCAT Gene:

MCAT

SOURCE GeneReport for Unigene cluster for MCAT Gene:

Hs.349111
genes like me logo Genes that share expression patterns with MCAT: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MCAT Gene

Orthologs for MCAT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCAT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCAT 34 35
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia MCAT 34 35
  • 86.14 (n)
cow
(Bos Taurus)
Mammalia MCAT 34 35
  • 85.96 (n)
rat
(Rattus norvegicus)
Mammalia Mcat 34
  • 79.16 (n)
mouse
(Mus musculus)
Mammalia Mcat 34 16 35
  • 78.68 (n)
oppossum
(Monodelphis domestica)
Mammalia MCAT 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves MCAT 34 35
  • 71.57 (n)
lizard
(Anolis carolinensis)
Reptilia MCAT 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mcat 34
  • 66.85 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30452 34
zebrafish
(Danio rerio)
Actinopterygii mcat 34 35
  • 63 (n)
MCAT (2 of 2) 35
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta beg 34 35
  • 57.42 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005650 34
  • 55.43 (n)
worm
(Caenorhabditis elegans)
Secernentea C50D2.9 34 35
  • 49.94 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G30200 34
  • 47.18 (n)
rice
(Oryza sativa)
Liliopsida Os03g0297400 34
  • 49.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3192 35
  • 41 (a)
OneToOne
Species where no ortholog for MCAT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MCAT Gene

ENSEMBL:
Gene Tree for MCAT (if available)
TreeFam:
Gene Tree for MCAT (if available)

Paralogs for MCAT Gene

No data available for Paralogs for MCAT Gene

Variants for MCAT Gene

Sequence variations from dbSNP and Humsavar for MCAT Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs111789572 -- 43,134,818(+) GGACC(A/G)CAGGA intron-variant
rs112069026 -- 43,143,444(+) GGGGC(A/T)TCCGG upstream-variant-2KB
rs112076476 -- 43,137,793(+) AAGAG(A/G)AACAG intron-variant
rs112236534 -- 43,143,268(+) GGAGG(C/T)ACCGG nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon
rs112412023 -- 43,137,753(+) TTAAA(-/A)TAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCAT Gene

Variant ID Type Subtype PubMed ID
nsv834214 CNV gain 17160897
esv3647855 CNV loss 21293372
esv33816 CNV gain 17666407
esv2762124 CNV gain 21179565

Variation tolerance for MCAT Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.77; 89.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCAT Gene

Human Gene Mutation Database (HGMD)
MCAT
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCAT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCAT Gene

Disorders for MCAT Gene

MalaCards: The human disease database

(1) MalaCards diseases for MCAT Gene - From: DISEASES

Disorder Aliases PubMed IDs
middle ear disease
  • disorder of middle ear
- elite association - COSMIC cancer census association via MalaCards
Search MCAT in MalaCards View complete list of genes associated with diseases

Relevant External Links for MCAT

Genetic Association Database (GAD)
MCAT
Human Genome Epidemiology (HuGE) Navigator
MCAT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCAT
genes like me logo Genes that share disorders with MCAT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MCAT Gene

Publications for MCAT Gene

  1. Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein. (PMID: 12882974) Zhang L. … Smith S. (J. Biol. Chem. 2003) 2 3 4 64
  2. Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation. (PMID: 20564319) Kim S.T. … Sun J. (Prostate 2010) 3 46 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. (PMID: 19767753) Eeles R.A. … Easton D.F. (Nat. Genet. 2009) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for MCAT Gene

Sources for MCAT Gene

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