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Aliases for MCAT Gene

Aliases for MCAT Gene

  • Malonyl CoA:ACP Acyltransferase (Mitochondrial) 2 3
  • Mitochondrial Malonyl CoA:ACP Acyltransferase 3 4
  • [Acyl-Carrier-Protein] Malonyltransferase 3 4
  • Mitochondrial Malonyltransferase 3 4
  • MCT 3 4
  • MT 3 4
  • Malonyl-CoA-Acyl Carrier Protein Transacylase, Mitochondrial 3
  • Malonyl-CoA:Acyl Carrier Protein Transacylase, Mitochondrial 3
  • EC 2.3.1.39 4
  • FASN2C 3
  • NET62 3
  • FabD 3

External Ids for MCAT Gene

Summaries for MCAT Gene

Entrez Gene Summary for MCAT Gene

  • The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2012]

GeneCards Summary for MCAT Gene

MCAT (Malonyl CoA:ACP Acyltransferase (Mitochondrial)) is a Protein Coding gene. Diseases associated with MCAT include vestibular neuronitis and neuronitis. Among its related pathways are Metabolism and Fatty acid metabolism. GO annotations related to this gene include transferase activity and [acyl-carrier-protein] S-malonyltransferase activity.

UniProtKB/Swiss-Prot for MCAT Gene

  • Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondrias.

Gene Wiki entry for MCAT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCAT Gene

Genomics for MCAT Gene

Genomic Location for MCAT Gene

Start:
43,132,206 bp from pter
End:
43,143,397 bp from pter
Size:
11,192 bases
Orientation:
Minus strand

Genomic View for MCAT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCAT Gene

Regulatory Elements for MCAT Gene

Proteins for MCAT Gene

  • Protein details for MCAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVS2-FABD_HUMAN
    Recommended name:
    Malonyl-CoA-acyl carrier protein transacylase, mitochondrial
    Protein Accession:
    Q8IVS2
    Secondary Accessions:
    • B0QY72
    • O95510
    • O95511

    Protein attributes for MCAT Gene

    Size:
    390 amino acids
    Molecular mass:
    42962 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MCAT Gene

    Alternative splice isoforms for MCAT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCAT Gene

Proteomics data for MCAT Gene at MOPED

Post-translational modifications for MCAT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MCAT Gene

No data available for DME Specific Peptides for MCAT Gene

Domains for MCAT Gene

UniProtKB/Swiss-Prot:

FABD_HUMAN
Family:
  • Belongs to the type II malonyltransferase family.:
    • Q8IVS2
genes like me logo Genes that share domains with MCAT: view

No data available for Gene Families for MCAT Gene

Function for MCAT Gene

Molecular function for MCAT Gene

UniProtKB/Swiss-Prot CatalyticActivity: Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].
UniProtKB/Swiss-Prot Function: Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondrias.

Enzyme Numbers (IUBMB) for MCAT Gene

Gene Ontology (GO) - Molecular Function for MCAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity IDA 12882974
GO:0016740 transferase activity IDA 12882974
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MCAT: view
genes like me logo Genes that share phenotypes with MCAT: view

miRNA for MCAT Gene

miRTarBase miRNAs that target MCAT

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MCAT Gene

Localization for MCAT Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCAT Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCAT Gene COMPARTMENTS Subcellular localization image for MCAT gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MCAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 12882974
genes like me logo Genes that share ontologies with MCAT: view

Pathways for MCAT Gene

genes like me logo Genes that share pathways with MCAT: view

Pathways by source for MCAT Gene

UniProtKB/Swiss-Prot Q8IVS2-FABD_HUMAN

  • Pathway: Lipid metabolism; fatty acid biosynthesis

Gene Ontology (GO) - Biological Process for MCAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006633 fatty acid biosynthetic process IEA --
GO:0008152 metabolic process IDA 12882974
genes like me logo Genes that share ontologies with MCAT: view

Compounds for MCAT Gene

(2) HMDB Compounds for MCAT Gene

Compound Synonyms Cas Number PubMed IDs
Coenzyme A
  • Acetoacetyl coenzyme A sodium salt
85-61-0
Malonyl-CoA
  • Malonyl Coenzyme A
524-14-1

(1) Drugbank Compounds for MCAT Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
3,6,9,12,15-PENTAOXAHEPTADECAN-1-OL
target
genes like me logo Genes that share compounds with MCAT: view

Transcripts for MCAT Gene

Unigene Clusters for MCAT Gene

Malonyl CoA:ACP acyltransferase (mitochondrial):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MCAT Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
SP1: - - -
SP2: - - - -
SP3: -
SP4: - - -
SP5: - -

Relevant External Links for MCAT Gene

GeneLoc Exon Structure for
MCAT
ECgene alternative splicing isoforms for
MCAT

Expression for MCAT Gene

mRNA expression in normal human tissues for MCAT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCAT Gene

SOURCE GeneReport for Unigene cluster for MCAT Gene Hs.349111

genes like me logo Genes that share expressions with MCAT: view

Orthologs for MCAT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCAT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCAT 36
  • 99.57 (n)
  • 99.49 (a)
MCAT 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MCAT 36
  • 85.96 (n)
  • 82.88 (a)
MCAT 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCAT 36
  • 86.14 (n)
  • 83.71 (a)
MCAT 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcat 36
  • 78.68 (n)
  • 76.58 (a)
Mcat 16
Mcat 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCAT 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcat 36
  • 79.16 (n)
  • 77.84 (a)
chicken
(Gallus gallus)
Aves MCAT 36
  • 71.57 (n)
  • 69.75 (a)
MCAT 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCAT 37
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.30452 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mcat 36
  • 66.85 (n)
  • 66.95 (a)
zebrafish
(Danio rerio)
Actinopterygii mcat 36
  • 63 (n)
  • 63.3 (a)
mcat 37
  • 57 (a)
OneToMany
MCAT (2 of 2) 37
  • 61 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005650 36
  • 55.43 (n)
  • 50.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta beg 36
  • 57.42 (n)
  • 49.35 (a)
beg 37
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C50D2.9 36
  • 49.94 (n)
  • 42.96 (a)
C50D2.9 37
  • 31 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G30200 36
  • 47.18 (n)
  • 41.89 (a)
rice
(Oryza sativa)
Liliopsida Os03g0297400 36
  • 49.38 (n)
  • 43.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3192 37
  • 41 (a)
OneToOne
Species with no ortholog for MCAT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MCAT Gene

ENSEMBL:
Gene Tree for MCAT (if available)
TreeFam:
Gene Tree for MCAT (if available)

Paralogs for MCAT Gene

No data available for Paralogs for MCAT Gene

Variants for MCAT Gene

Sequence variations from dbSNP and Humsavar for MCAT Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs7402 -- 43,133,023(+) GTCAT(C/T)GCATT utr-variant-3-prime, nc-transcript-variant
rs13815 - 43,133,308(-) CCACG(C/G)GCATA utr-variant-3-prime, reference, missense, nc-transcript-variant
rs737802 -- 43,132,787(+) GATTC(C/T)AGCTT utr-variant-3-prime, nc-transcript-variant
rs872841 -- 43,134,694(-) GCACA(C/G)AAGCA intron-variant
rs872842 -- 43,134,625(-) CAGGC(A/T)ACAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCAT Gene

Variant ID Type Subtype PubMed ID
nsv834214 CNV Gain 17160897
esv33816 CNV Gain 17666407
dgv4986n71 CNV Loss 21882294
dgv4987n71 CNV Loss 21882294
nsv915201 CNV Loss 21882294
dgv4988n71 CNV Loss 21882294

Relevant External Links for MCAT Gene

HapMap Linkage Disequilibrium report
MCAT

Disorders for MCAT Gene

(2) University of Copenhagen DISEASES for MCAT Gene

Relevant External Links for MCAT

Genetic Association Database (GAD)
MCAT
Human Genome Epidemiology (HuGE) Navigator
MCAT
genes like me logo Genes that share disorders with MCAT: view

No data available for UniProtKB/Swiss-Prot for MCAT Gene

Publications for MCAT Gene

  1. Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein. (PMID: 12882974) Zhang L. … Smith S. (J. Biol. Chem. 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  4. Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation. (PMID: 20564319) Kim S.T. … Sun J. (Prostate 2010) 3 49
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49

Products for MCAT Gene

Sources for MCAT Gene

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