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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MCAT Gene

protein-coding   GIFtS: 60
GCID: GC22M043528

Malonyl CoA:ACP Acyltransferase (Mitochondrial)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Malonyl CoA:ACP Acyltransferase (Mitochondrial)1 2     FASN2C2
Mitochondrial Malonyl CoA:ACP Acyltransferase2 3     NET622
Mitochondrial Malonyltransferase2 3     fabD2
MCT2 3     Malonyl-CoA-Acyl Carrier Protein Transacylase, Mitochondrial2
MT2 3     Malonyl-CoA:Acyl Carrier Protein Transacylase, Mitochondrial2
[Acyl-Carrier-Protein] Malonyltransferase2 3     EC 2.3.1.393

External Ids:    HGNC: 296221   Entrez Gene: 273492   Ensembl: ENSG000001002947   OMIM: 6144795   UniProtKB: Q8IVS23   

Export aliases for MCAT gene to outside databases

Previous GC identifers: GC22M041858 GC22M026486


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MCAT Gene:
The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a
malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a
fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type
I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different
isoforms. (provided by RefSeq, Mar 2012)

GeneCards Summary for MCAT Gene: 
MCAT (malonyl CoA:ACP acyltransferase (mitochondrial)) is a protein-coding gene. Diseases associated with MCAT include vestibular neuronitis, and leptospirosis, and among its related super-pathways are Saturated fatty acid biosynthesis and Metabolism. GO annotations related to this gene include transferase activity and [acyl-carrier-protein] S-malonyltransferase activity.

UniProtKB/Swiss-Prot: FABD_HUMAN, Q8IVS2
Function: Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the
phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the
biosynthesis of fatty acids in mitochondrias

Gene Wiki entry for MCAT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MCAT gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMCAT promoter sequence
   Search SABiosciences Chromatin IP Primers for MCAT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCAT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.31   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

MCAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCAT gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M043528:  view genomic region     (about GC identifiers)

Start:
43,528,212 bp from pter      End:
43,539,403 bp from pter
Size:
11,192 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FABD_HUMAN, Q8IVS2 (See protein sequence)
Recommended Name: Malonyl-CoA-acyl carrier protein transacylase, mitochondrial precursor  
Size: 390 amino acids; 42962 Da
Subcellular location: Mitochondrion
1 PDB 3D structure from and Proteopedia for MCAT:
2C2N (3D)    
Secondary accessions: O95510 O95511
Alternative splicing: 2 isoforms:  Q8IVS2-1   Q8IVS2-2   

Explore the universe of human proteins at neXtProt for MCAT: NX_Q8IVS2

Explore proteomics data for MCAT at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IVS2

  • MCAT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MCAT Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_055322.1  NP_775738.3  

    ENSEMBL proteins: 
     ENSP00000331306   ENSP00000290429  

    Human Recombinant Protein Products for MCAT: 
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    Novus Biologicals MCAT Proteins
    Novus Biologicals MCAT Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MCAT 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA12882974

    MCAT for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for MCAT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR016035 Acyl_Trfase/lysoPLipase
     IPR016036 Malonyl_transacylase_ACP-bd
     IPR014043 Acyl_transferase
     IPR001227 Ac_transferase_dom

    Graphical View of Domain Structure for InterPro Entry Q8IVS2

    ProtoNet protein and cluster: Q8IVS2

    1 Blocks protein domain: IPB001227 Acyl transferase domain

    UniProtKB/Swiss-Prot: FABD_HUMAN, Q8IVS2
    Similarity: Belongs to the type II malonyltransferase family


    MCAT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FABD_HUMAN, Q8IVS2
    Function: Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the
    phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the
    biosynthesis of fatty acids in mitochondrias
    Catalytic activity: Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein]

         Enzyme Number (IUBMB): EC 2.3.1.391

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004314[acyl-carrier-protein] S-malonyltransferase activity IDA12882974
    GO:0005515protein binding ----
    GO:0016740transferase activity IDA12882974
         
    MCAT for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MCAT:
     Increased gamma-H2AX phosphory 

         14 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mcat):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  integument 
     mortality/aging  muscle  normal  skeleton 

    MCAT for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MCAT 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MCAT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MCAT 
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    hsa-miR-214 hsa-miR-330-3p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidMCAT 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCAT


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MCAT About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Saturated fatty acid biosynthesis
    Fatty acid biosynthesis0.50
    2Metabolism
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2         Kegg Pathways  (Kegg details for MCAT):
        Fatty acid biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: FABD_HUMAN, Q8IVS2
    Pathway: Lipid metabolism; fatty acid biosynthesis


    MCAT for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MCAT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/251 Interacting proteins for MCAT (Q8IVS22, 3 ENSP000002904294) via UniProtKB, MINT, STRING, and/or I2D (see all 251)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    SUMO3P558543, ENSP000003303434I2D: score=1 STRING: ENSP00000330343
    AARS2Q5JTZ92MINT-8079030
    AASSQ9UDR52MINT-8079030
    ABCB7O750272MINT-8079030
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006633fatty acid biosynthetic process IEA--
    GO:0008152metabolic process IDA12882974

    MCAT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MCAT (FABD)

    2 HMDB Compounds for MCAT    About this table
    CompoundSynonyms CAS #PubMed Ids
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Malonyl-CoAMalonyl Coenzyme A (see all 11)524-14-1--

    1 DrugBank Compound for MCAT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3,6,9,12,15-PENTAOXAHEPTADECAN-1-OL-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about MCAT / FABD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MCAT gene (2 alternative transcripts): 
    NM_014507.3  NM_173467.4  

    Unigene Cluster for MCAT:

    Malonyl CoA:ACP acyltransferase (mitochondrial)
    Hs.349111  [show with all ESTs]
    Unigene Representative Sequence: NM_173467
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327555 ENST00000290429(uc003bdl.1 uc003bdm.1) ENST00000464244

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MCAT:
    hsa-miR-214 hsa-miR-330-3p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidMCAT 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene ORF clones in mouse, rat for MCAT
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    GenScript: all cDNA clones in your preferred vector (see all 2): MCAT (NM_173467)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCAT
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCAT

    Additional mRNA sequence: 

    AK314059.1 AL359401.1 AL359403.1 BC030985.1 BC042195.1 NR_046423.1 

    6 DOTS entries:

    DT.100791112  DT.214995  DT.100791103  DT.100791115  DT.100649324  DT.99931642 

    24/148 AceView cDNA sequences (see all 148):

    AL359403 AI560418 BE888005 NM_173467 Z39496 BX111669 BM761404 AA478384 
    BE855429 BM762651 AA449980 BM793204 BM853555 BM669538 BQ941346 AL359401 
    AI051149 NM_014507 AI095109 AA827477 CR599689 AI379511 AA402283 CR604802 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MCAT    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
    SP1:                                -     -           -                           
    SP2:                                -     -           -     -                     
    SP3:                                -                                             
    SP4:                                      -           -     -                     
    SP5:                                -     -                                       


    ECgene alternative splicing isoforms for MCAT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MCAT expression in normal human tissues (normalized intensities)      MCAT embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGACCTGGA
    MCAT Expression
    About this image


    MCAT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Epithelium
             nasopharynx ; respiratory epithelial cells   
             bronchial epithelial cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Breast
             breast ; myoepithelial cells   
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Islets of Langerhans
             pancreas ; exocrine glandular cells   

    See MCAT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MCAT

    SOURCE GeneReport for Unigene cluster: Hs.349111
        SABiosciences Custom PCR Arrays for MCAT
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCAT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MCAT gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mcat1 , 5 malonyl CoA:ACP acyltransferase (mitochondrial)1, 5 78.68(n)1
    76.58(a)1
      15 (39.40 cM)5
    2237221  NM_001030014.21  NP_001025185.11 
     835467975 
    chicken
    (Gallus gallus)
    Aves MCAT1 malonyl CoA:ACP acyltransferase (mitochondrial) 71.37(n)
    69.29(a)
      427934  XM_425506.3  XP_425506.3 
    lizard
    (Anolis carolinensis)
    Reptilia MCAT6
    Uncharacterized protein
    61(a)
    1 ↔ 1
    5(86777850-86785537)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.304522 Xenopus laevis transcribed sequence with weak similarity more 77.61(n)    48041910 
    zebrafish
    (Danio rerio)
    Actinopterygii mcat1 malonyl CoA:ACP acyltransferase (mitochondrial) 63(n)
    63.3(a)
      564111  NM_001045043.1  NP_001038508.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta beg1 bad egg 57.42(n)
    49.35(a)
      39910  NM_140693.2  NP_648950.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C50D2.91 Protein C50D2.9 49.66(n)
    42.18(a)
      259414  NM_182154.2  NP_871954.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G302001 [acyl-carrier-protein] S-malonyltransferase 47.34(n)
    42.03(a)
      817570  NM_128573.3  NP_565697.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02974001 hypothetical protein 49.71(n)
    43.6(a)
      4332547  NM_001056372.1  NP_001049837.1 


    ENSEMBL Gene Tree for MCAT (if available)
    TreeFam Gene Tree for MCAT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/391 SNPs in MCAT are shown (see all 391)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887516241,2
    --43527728(+) CTCCTC/GAGGCT 3 -- ds5001 int10--------
    rs775919801,2
    C,F--43527731(+) CTGAGG/ACTGCC 3 -- ds5001 int11Minor allele frequency- A:0.10WA 118
    rs1811277001,2
    --43527758(+) AGGGAA/GGGAGC 3 -- ds5001 int10--------
    rs782683851,2
    F--43527798(+) AAGTTC/ATCTGT 3 -- ds5001 int11Minor allele frequency- A:0.04WA 118
    rs1460148451,2
    --43527854(+) TCCCAA/GGGACG 3 -- ds5001 int10--------
    rs1388521831,2
    C--43527886(+) ATCACA/GTCGCA 3 -- ds5001 int10--------
    rs1412400111,2
    --43527923(+) TTCGAA/GACATG 3 -- ds5001 int10--------
    rs562456061,2
    C,F--43527971(+) GGTGTG/ATAATG 3 -- ds5001 int11Minor allele frequency- A:0.50WA 2
    rs1181007391,2
    F--43528053(+) AGCTGG/CGCCCT 3 -- ds5001 int11Minor allele frequency- C:0.03EA 120
    rs1494700331,2
    C--43528140(+) ACATTC/TTAAGA 3 -- ds5001 int10--------

    HapMap Linkage Disequilibrium report for MCAT (43528212 - 43539403 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MCAT:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv4988n71CNV Loss21882294
    nsv915201CNV Loss21882294
    dgv4987n71CNV Loss21882294
    dgv4986n71CNV Loss21882294
    esv33816CNV Gain17666407
    nsv834214CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614479    OMIM disorders: --

    7 diseases for MCAT:    About MalaCards
    vestibular neuronitis    leptospirosis    pneumonia    tuberculosis
    prostate cancer    prostatitis    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for MCAT:
    Leptospirosis     Vestibular neuronitis

    MCAT for disorders           About GeneDecksing

    Genetic Association Database (GAD): MCAT
    Human Genome Epidemiology (HuGE) Navigator: MCAT (5 documents)

    Export disorders for MCAT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MCAT gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with MCAT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein. (PubMed id 12882974)1, 2, 3 Zhang L.... Smith S. (2003)
    2. Prostate cancer risk-associated variants reported fro m genome-wide association studies: meta-analysis and their contribution to gene tic Variation. (PubMed id 20564319)1, 4 Kim S.T....Sun J. (2010)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Identification of seven new prostate cancer susceptib ility loci through a genome-wide association study. (PubMed id 19767753)1, 4 Eeles R.A....Cao G. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)1, 2 Collins J.E.... Dunham I. (2003)
    7. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27349 HGNC: 29622 AceView: MT Ensembl:ENSG00000100294 euGenes: HUgn27349
    ECgene: MCAT Kegg: 27349 H-InvDB: MCAT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MCAT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MCAT gene:
    Search GeneIP for patents involving MCAT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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