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Aliases for MCAM Gene

Aliases for MCAM Gene

  • Melanoma Cell Adhesion Molecule 2 3 4
  • MUC18 3 4 6
  • S-Endo 1 Endothelial-Associated Antigen 3 4
  • Melanoma-Associated Antigen MUC18 3 4
  • Cell Surface Glycoprotein P1H12 3 4
  • Melanoma-Associated Antigen A32 3 4
  • Gicerin 2 3
  • CD146 3 6
  • Cell Surface Glycoprotein MUC18 3
  • Melanoma Adhesion Molecule 3
  • CD146 Antigen 4

External Ids for MCAM Gene

Previous GeneCards Identifiers for MCAM Gene

  • GC11P121109
  • GC11M120690
  • GC11M119212
  • GC11M118716
  • GC11M118684
  • GC11M119179
  • GC11M115119

Summaries for MCAM Gene

GeneCards Summary for MCAM Gene

MCAM (Melanoma Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with MCAM include placental site trophoblastic tumor and epithelioid trophoblastic tumor. An important paralog of this gene is ALCAM.

UniProtKB/Swiss-Prot for MCAM Gene

  • Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Gene Wiki entry for MCAM Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCAM Gene

Genomics for MCAM Gene

Regulatory Elements for MCAM Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MCAM Gene

Start:
119,308,524 bp from pter
End:
119,321,521 bp from pter
Size:
12,998 bases
Orientation:
Minus strand

Genomic View for MCAM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCAM Gene

Proteins for MCAM Gene

  • Protein details for MCAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43121-MUC18_HUMAN
    Recommended name:
    Cell surface glycoprotein MUC18
    Protein Accession:
    P43121
    Secondary Accessions:
    • O95812
    • Q59E86
    • Q6PHR3
    • Q6ZTR2

    Protein attributes for MCAM Gene

    Size:
    646 amino acids
    Molecular mass:
    71607 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD93162.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MCAM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCAM Gene

Proteomics data for MCAM Gene at MOPED

Post-translational modifications for MCAM Gene

  • Glycosylation at Asn56, Asn418, Asn449, Asn467, Asn508, Asn518, Asn527, and Asn544
  • Modification sites at PhosphoSitePlus

Other Protein References for MCAM Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MCAM (MCAM)

No data available for DME Specific Peptides for MCAM Gene

Domains for MCAM Gene

Gene Families for MCAM Gene

HGNC:
  • C2SET :Immunoglobulin superfamily / C2-set domain containing
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • VSET :Immunoglobulin superfamily / V-set domain containing

Suggested Antigen Peptide Sequences for MCAM Gene

Graphical View of Domain Structure for InterPro Entry

P43121

UniProtKB/Swiss-Prot:

MUC18_HUMAN :
  • P43121
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with MCAM: view

Function for MCAM Gene

Molecular function for MCAM Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Gene Ontology (GO) - Molecular Function for MCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with MCAM: view
genes like me logo Genes that share phenotypes with MCAM: view

Animal Models for MCAM Gene

MGI Knock Outs for MCAM:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MCAM

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MCAM Gene

Localization for MCAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCAM Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCAM Gene COMPARTMENTS Subcellular localization image for MCAM gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane NAS 8378324
GO:0005925 focal adhesion IDA 21423176
GO:0009897 external side of plasma membrane IDA 20354148
genes like me logo Genes that share ontologies with MCAM: view

Pathways for MCAM Gene

SuperPathways for MCAM Gene

No Data Available

PCR Array Products

Gene Ontology (GO) - Biological Process for MCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 23878390
GO:0003094 glomerular filtration IEP 20354148
GO:0007155 cell adhesion IEA --
GO:0009653 anatomical structure morphogenesis TAS 8378324
GO:0030335 positive regulation of cell migration IEA --
genes like me logo Genes that share ontologies with MCAM: view

No data available for Pathways by source for MCAM Gene

Compounds for MCAM Gene

(1) HMDB Compounds for MCAM Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(2) Novoseek inferred chemical compound relationships for MCAM Gene

Compound -log(P) Hits PubMed IDs
cyclic amp 5.16 4
tyrosine 0 4
genes like me logo Genes that share compounds with MCAM: view

Transcripts for MCAM Gene

Unigene Clusters for MCAM Gene

Melanoma cell adhesion molecule:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MCAM

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCAM Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - - - -
SP8: - - - - - -
SP9:
SP10: - - - -
SP11: - - - - - - - - -
SP12: - - - - - - - -
SP13: - - -
SP14: - - - - - -
SP15:
SP16: - - - - -
SP17: - - - - - -
SP18:

ExUns: 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17:
SP18:

Relevant External Links for MCAM Gene

GeneLoc Exon Structure for
MCAM
ECgene alternative splicing isoforms for
MCAM

Expression for MCAM Gene

mRNA expression in normal human tissues for MCAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MCAM Gene

This gene is overexpressed in Artery - Tibial (10.7), Artery - Coronary (6.6), and Artery - Aorta (5.1).

Protein differential expression in normal tissues for MCAM Gene

This gene is overexpressed in Adipocyte (16.2), Seminal vesicle (7.3), and Nasopharynx (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCAM Gene

SOURCE GeneReport for Unigene cluster for MCAM Gene Hs.599039

mRNA Expression by UniProt/SwissProt for MCAM Gene

P43121-MUC18_HUMAN
Tissue specificity: Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis
genes like me logo Genes that share expressions with MCAM: view

Expression partners for MCAM Gene

In Situ Assay Products

Orthologs for MCAM Gene

This gene was present in the common ancestor of chordates.

Orthologs for MCAM Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MCAM 35
  • 85.57 (n)
  • 83.66 (a)
MCAM 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcam 35
  • 80.75 (n)
  • 76.47 (a)
Mcam 16
Mcam 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MCAM 35
  • 99.33 (n)
  • 98.92 (a)
MCAM 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcam 35
  • 81.27 (n)
  • 75.54 (a)
cow
(Bos Taurus)
Mammalia MCAM 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCAM 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
OneToMany
-- 36
  • 45 (a)
OneToMany
chicken
(Gallus gallus)
Aves MCAM 35
  • 56.67 (n)
  • 43.65 (a)
MCAM 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCAM 36
  • 31 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mcam 35
  • 49.06 (n)
  • 38.77 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101884730 35
  • 50.45 (n)
  • 38.31 (a)
MCAM (2 of 3) 36
  • 35 (a)
OneToMany
MCAM (3 of 3) 36
  • 36 (a)
OneToMany
mcamb 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToMany
Species with no ortholog for MCAM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MCAM Gene

ENSEMBL:
Gene Tree for MCAM (if available)
TreeFam:
Gene Tree for MCAM (if available)

Paralogs for MCAM Gene

Paralogs for MCAM Gene

genes like me logo Genes that share paralogs with MCAM: view

Variants for MCAM Gene

Sequence variations from dbSNP and Humsavar for MCAM Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7914 -- 119,309,606(-) TCTTG(C/T)AGAAC utr-variant-3-prime
rs11033 -- 119,308,969(-) AAAGA(C/T)ACGTG utr-variant-3-prime
rs13612 -- 119,308,958(-) CCTGC(A/G)GTGAG utr-variant-3-prime
rs13699 -- 119,308,942(-) TGGGC(A/G)CTGTT utr-variant-3-prime
rs13700 -- 119,308,840(-) GAGCA(C/G/T)ACAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MCAM Gene

Variant ID Type Subtype PubMed ID
nsv898417 CNV Loss 21882294
nsv898418 CNV Loss 21882294

Relevant External Links for MCAM Gene

HapMap Linkage Disequilibrium report
MCAM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCAM Gene

Disorders for MCAM Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MCAM Gene in MalaCards »

(3) Diseases for MCAM Gene including...

(3) University of Copenhagen DISEASES for MCAM Gene

(16) Novoseek inferred disease relationships for MCAM Gene

Disease -log(P) Hits PubMed IDs
melanoma 73.1 57
metastatic melanoma 69.8 10
cell damage 53.5 6
metastasis 50.7 17
tumors 36.9 33
genes like me logo Genes that share disorders with MCAM: view

No data available for OMIM , UniProtKB/Swiss-Prot , Genatlas and External Links for MCAM Gene

Publications for MCAM Gene

  1. The progression associated antigen MUC18: a unique member of the immunoglobulin supergene family. (PMID: 8292890) Johnson J.P. … Sers C. (Melanoma Res. 1993) 3 4 23
  2. Genomic organization of the melanoma-associated glycoprotein MUC18: implications for the evolution of the immunoglobulin domains. (PMID: 8378324) Sers C. … Johnson J.P. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 4 23
  3. Assignment of the human melanoma cell adhesion molecule gene (MCAM) to chromosome 11 band q23.3 by radiation hybrid mapping. (PMID: 10702685) Kuske M.D. … Johnson J.P. (Cytogenet. Cell Genet. 1999) 2 3 23
  4. MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily. (PMID: 2602381) Lehmann J.M. … Johnson J.P. (Proc. Natl. Acad. Sci. U.S.A. 1989) 2 3 4
  5. Isolation and functional characterization of the A32 melanoma- associated antigen. (PMID: 8162602) Shih I.-M. … Herlyn M. (Cancer Res. 1994) 3 4

Products for MCAM Gene

Sources for MCAM Gene

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