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Aliases for MCAM Gene

Aliases for MCAM Gene

  • Melanoma Cell Adhesion Molecule 2 3 4 5
  • S-Endo 1 Endothelial-Associated Antigen 3 4
  • Melanoma-Associated Antigen MUC18 3 4
  • Cell Surface Glycoprotein P1H12 3 4
  • Melanoma-Associated Antigen A32 3 4
  • Gicerin 2 3
  • MUC18 3 4
  • Cell Surface Glycoprotein MUC18 3
  • Melanoma Adhesion Molecule 3
  • CD146 Antigen 4
  • CD146 3

External Ids for MCAM Gene

Previous GeneCards Identifiers for MCAM Gene

  • GC11P121109
  • GC11M120690
  • GC11M119212
  • GC11M118716
  • GC11M118684
  • GC11M119179
  • GC11M115119

Summaries for MCAM Gene

GeneCards Summary for MCAM Gene

MCAM (Melanoma Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with MCAM include Melanoma and Skin Melanoma. Among its related pathways are Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers and Adhesion. An important paralog of this gene is BCAM.

UniProtKB/Swiss-Prot for MCAM Gene

  • Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Gene Wiki entry for MCAM Gene

Additional gene information for MCAM Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCAM Gene

Genomics for MCAM Gene

Regulatory Elements for MCAM Gene

Enhancers for MCAM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H119314 1.3 ENCODE dbSUPER 11 +2.7 2712 8 HDGF PKNOX1 ARNT SIN3A ARID4B FEZF1 ZNF2 ZNF766 ZNF143 SP3 RNF26 ENSG00000245869 MCAM BCL9L CBL IFT46 RPS25 ENSG00000271751 GC11M119321 MIR6756
GH11H119305 1.2 Ensembl ENCODE dbSUPER 9.3 +15.2 15171 2 CTCF MAZ CEBPB MAX CEBPG RAD21 NFIL3 POLR2A CEBPA PRDM10 HINFP RNF26 ENSG00000245385 MFRP C1QTNF5 NLRX1 ABCG4 DPAGT1 C2CD2L MCAM
GH11H118529 1 ENCODE 10.3 +790.6 790599 3 HDGF ATF1 ARID4B SIN3A DMAP1 ZNF2 ETS1 GLIS2 ZNF207 KLF7 BCL9L ENSG00000254909 UBE4A RPL23AP64 ARCN1 IFT46 ENSG00000254428 KMT2A ENSG00000245869 DPAGT1
GH11H119217 1 Ensembl ENCODE 9.2 +103.2 103187 2 JUN CEBPG FOSL1 TCF12 MTA3 GATA3 POLR2A FOSL2 ZSCAN29 TRIM24 HINFP NLRX1 CBL PDZD3 ABCG4 DPAGT1 C2CD2L H2AFX HMBS MFRP
GH11H119257 0.8 ENCODE 8.8 +62.1 62050 3 HDGF PKNOX1 BATF ATF7 PRDM10 NFE2 ETV6 IKZF2 SMARCA5 CEBPB CBL PDZD3 NLRX1 HMBS ABCG4 MFRP C1QTNF5 DPAGT1 C2CD2L H2AFX
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MCAM on UCSC Golden Path with GeneCards custom track

Promoters for MCAM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000266138 321 401 HDAC1 HDGF TBP RB1 NFRKB SIN3A ZNF766 GLIS2 ZNF143 ATF7

Genomic Location for MCAM Gene

Chromosome:
11
Start:
119,308,524 bp from pter
End:
119,321,521 bp from pter
Size:
12,998 bases
Orientation:
Minus strand

Genomic View for MCAM Gene

Genes around MCAM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCAM Gene

Proteins for MCAM Gene

  • Protein details for MCAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43121-MUC18_HUMAN
    Recommended name:
    Cell surface glycoprotein MUC18
    Protein Accession:
    P43121
    Secondary Accessions:
    • O95812
    • Q59E86
    • Q6PHR3
    • Q6ZTR2

    Protein attributes for MCAM Gene

    Size:
    646 amino acids
    Molecular mass:
    71607 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD93162.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MCAM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCAM Gene

Post-translational modifications for MCAM Gene

  • Glycosylation at Asn56, posLast=418418, Asn449, posLast=467467, posLast=508508, Asn518, posLast=527527, and Asn544
  • Modification sites at PhosphoSitePlus

Other Protein References for MCAM Gene

Assay Products

  • Cloud-Clone Corp. Assay Kits for MCAM

No data available for DME Specific Peptides for MCAM Gene

Domains & Families for MCAM Gene

Suggested Antigen Peptide Sequences for MCAM Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MCAM: view

No data available for UniProtKB/Swiss-Prot for MCAM Gene

Function for MCAM Gene

Molecular function for MCAM Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Phenotypes From GWAS Catalog for MCAM Gene

genes like me logo Genes that share phenotypes with MCAM: view

Animal Models for MCAM Gene

MGI Knock Outs for MCAM:

Animal Model Products

  • Taconic Biosciences Mouse Models for MCAM

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MCAM
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MCAM Gene

Localization for MCAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCAM Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCAM gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 3
cytoskeleton 2
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane NAS 8378324
GO:0005925 focal adhesion IDA 21423176
GO:0009897 external side of plasma membrane IDA 20354148
genes like me logo Genes that share ontologies with MCAM: view

Pathways & Interactions for MCAM Gene

genes like me logo Genes that share pathways with MCAM: view

Pathways by source for MCAM Gene

1 Cell Signaling Technology pathway for MCAM Gene

Gene Ontology (GO) - Biological Process for MCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 23878390
GO:0003094 glomerular filtration IEP 20354148
GO:0007155 cell adhesion IEA,TAS --
GO:0009653 anatomical structure morphogenesis TAS 8378324
GO:0030335 positive regulation of cell migration IEA --
genes like me logo Genes that share ontologies with MCAM: view

No data available for SIGNOR curated interactions for MCAM Gene

Drugs & Compounds for MCAM Gene

(3) Drugs for MCAM Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with MCAM: view

Transcripts for MCAM Gene

Unigene Clusters for MCAM Gene

Melanoma cell adhesion molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MCAM
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MCAM Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - - - -
SP8: - - - - - -
SP9:
SP10: - - - -
SP11: - - - - - - - - -
SP12: - - - - - - - -
SP13: - - -
SP14: - - - - - -
SP15:
SP16: - - - - -
SP17: - - - - - -
SP18:

ExUns: 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17:
SP18:

Relevant External Links for MCAM Gene

GeneLoc Exon Structure for
MCAM
ECgene alternative splicing isoforms for
MCAM

Expression for MCAM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MCAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MCAM Gene

This gene is overexpressed in Artery - Tibial (x10.7), Artery - Coronary (x6.6), and Artery - Aorta (x5.1).

Protein differential expression in normal tissues from HIPED for MCAM Gene

This gene is overexpressed in Adipocyte (16.2), Seminal vesicle (7.3), and Nasopharynx (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MCAM Gene



Protein tissue co-expression partners for MCAM Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MCAM Gene:

MCAM

SOURCE GeneReport for Unigene cluster for MCAM Gene:

Hs.599039

mRNA Expression by UniProt/SwissProt for MCAM Gene:

P43121-MUC18_HUMAN
Tissue specificity: Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.

Evidence on tissue expression from TISSUES for MCAM Gene

  • Nervous system(5)
  • Liver(4.3)
  • Lung(4.2)
  • Heart(3.4)
  • Skin(3.4)
  • Kidney(3.3)
  • Muscle(2.9)
  • Intestine(2.8)
  • Blood(2.4)
  • Bone marrow(2.4)
  • Eye(2.2)
  • Stomach(2.1)
  • Lymph node(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with MCAM: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MCAM Gene

Orthologs for MCAM Gene

This gene was present in the common ancestor of chordates.

Orthologs for MCAM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCAM 33 34
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia MCAM 33 34
  • 85.57 (n)
rat
(Rattus norvegicus)
Mammalia Mcam 33
  • 81.27 (n)
cow
(Bos Taurus)
Mammalia MCAM 34
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcam 33 16 34
  • 80.75 (n)
oppossum
(Monodelphis domestica)
Mammalia MCAM 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 45 (a)
OneToMany
-- 34
  • 43 (a)
OneToMany
chicken
(Gallus gallus)
Aves MCAM 33 34
  • 56.67 (n)
lizard
(Anolis carolinensis)
Reptilia MCAM 34
  • 31 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mcam 33
  • 49.06 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101884730 33
  • 50.45 (n)
MCAM (3 of 3) 34
  • 36 (a)
OneToMany
MCAM (2 of 3) 34
  • 35 (a)
OneToMany
mcamb 34
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 18 (a)
OneToMany
Species where no ortholog for MCAM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MCAM Gene

ENSEMBL:
Gene Tree for MCAM (if available)
TreeFam:
Gene Tree for MCAM (if available)

Paralogs for MCAM Gene

Paralogs for MCAM Gene

genes like me logo Genes that share paralogs with MCAM: view

Variants for MCAM Gene

Sequence variations from dbSNP and Humsavar for MCAM Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs886047815 Likely benign 119,308,073(+) AGTTA(-/GTTA)ACTAA downstream-variant-500B, utr-variant-3-prime
rs1000022573 -- 119,318,792(+) AAAAC(A/G)AAGCC upstream-variant-2KB
rs1000143348 -- 119,313,953(+) ATATA(C/T)GAGCA intron-variant, upstream-variant-2KB
rs1001098778 -- 119,312,622(+) CTCCA(C/T)TTCCA downstream-variant-500B, reference, missense
rs1001343806 -- 119,309,351(+) AGAGG(-/CAGA)CAGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MCAM Gene

Variant ID Type Subtype PubMed ID
nsv556469 CNV gain 21841781
nsv952747 CNV deletion 24416366

Variation tolerance for MCAM Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.18; 61.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MCAM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCAM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCAM Gene

Disorders for MCAM Gene

MalaCards: The human disease database

(6) MalaCards diseases for MCAM Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
skin melanoma
  • melanoma
uterine sarcoma
  • uterine corpus sarcoma
prostate cancer
  • prostate cancer, hereditary, 5
epithelioid cell melanoma
  • epithelioid melanoma
- elite association - COSMIC cancer census association via MalaCards
Search MCAM in MalaCards View complete list of genes associated with diseases

Relevant External Links for MCAM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCAM
genes like me logo Genes that share disorders with MCAM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MCAM Gene

Publications for MCAM Gene

  1. Assignment of the human melanoma cell adhesion molecule gene (MCAM) to chromosome 11 band q23.3 by radiation hybrid mapping. (PMID: 10702685) Kuske MD … Johnson JP (Cytogenetics and cell genetics 1999) 2 3 22 60
  2. Genomic organization of the melanoma-associated glycoprotein MUC18: implications for the evolution of the immunoglobulin domains. (PMID: 8378324) Sers C … Johnson JP (Proceedings of the National Academy of Sciences of the United States of America 1993) 3 4 22 60
  3. The progression associated antigen MUC18: a unique member of the immunoglobulin supergene family. (PMID: 8292890) Johnson JP … Sers C (Melanoma research 1993) 3 4 22 60
  4. MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily. (PMID: 2602381) Lehmann JM … Johnson JP (Proceedings of the National Academy of Sciences of the United States of America 1989) 2 3 4 60
  5. Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis. (PMID: 19703903) Melnikova VO … Bar-Eli M (The Journal of biological chemistry 2009) 3 22 60

Products for MCAM Gene

Sources for MCAM Gene

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