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MCAM Gene

protein-coding GIFtS: 59

GC11M118684

melanoma cell adhesion molecule
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD146 ^¹, ²
Gicerin ^²
MUC18 ^¹, ², ³

Descriptions
CD146 antigen ^³
Cell surface glycoprotein P1H12 ^³
Melanoma-associated antigen A32 ^³
Melanoma-associated antigen MUC18 ^³
S-endo 1 endothelial-associated antigen ^³
melanoma adhesion molecule ^²
melanoma cell adhesion molecule ^², ³

External Ids
HGNC: 6934¹
Entrez Gene: 4162²
UniProtKB: P43121³
Ensembl: ENSG00000076706⁷

Search outside databases for aliases for MCAM gene

Previous GC identifers: GC11P121109 GC11M120690 GC11M119212 GC11M118716

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MUC18_HUMAN, P43121

Function: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at

intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact

with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could

be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface

receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the

intracellular calcium concentration

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MCAM gene

Entrez Gene cytogenetic band: 11q23.3 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.3

MCAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M118684: (about GC identifiers)

Start:	118,684,444 bp from pter
End:	118,693,050 bp from pter
Size:	8,607 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_033899.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MUC18_HUMAN, P43121 (See protein sequence)

Recommended Name: Cell surface glycoprotein MUC18 precursor

Size: 646 amino acids; 71607 Da

Subcellular location: Membrane; Single-pass type I membrane protein

Secondary accessions: O95812 Q59E86 Q6PHR3 Q6ZTR2

Alternative splicing: 2 isoforms: P43121-1 P43121-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_006491.2

ENSEMBL proteins:

ENSP00000264036 ENSP00000376561

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CD146)
	Human Recombinant Proteins from Abnova (MCAM)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18029348
GO:0005737	cytoplasm	IDA	18029348
GO:0005794	Golgi apparatus	IDA	18029348
GO:0005886	plasma membrane	NAS	8378324
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for MCAM:

	Invitrogen Antibodies for MCAM
	Millipore Mono- and Polyclonal Antibodies for the study of MCAM
	Sigma-Aldrich Antibodies for MCAM
	R&D Systems Antibodies for MCAM (MCAM/CD146)
	Antibodies from Abcam (CD146), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MCAM)
	Novus Biologicals Antibodies for MCAM

Assays for MCAM:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P43121

ProtoNet protein and cluster: P43121

2 Blocks protein families:

IPB003598 Immunoglobulin C-2 type

IPB013162 CD80-like C2-set immunoglobulin

UniProtKB/Swiss-Prot: MUC18_HUMAN, P43121

Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MCAM)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006500

Applied Biosystems Silencer® siRNAs for MCAM

Sigma-Aldrich siRNA and siRNA Panels for MCAM

Sigma-Aldrich shRNA Panels and shRNA for MCAM

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MCAM
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_006500
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006500
untagged cDNA clone in CMV expression vector: NM_006500

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006500

UniProtKB/Swiss-Prot: MUC18_HUMAN, P43121

Function: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at

intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact

with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could

be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface

receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the

intracellular calcium concentration

1 MGI phenotypic allele for Mcam (no phenotypes)

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for MCAM

5/23 Interacting proteins for MCAM (ENSP00000264036³ P43121²) via UniProtKB, MINT, and/or STRING (see all 23 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATF7IP	Q6VMQ6²	MINT-61905
TFAP2A	ENSP00000368933³	STRING (score=.945)
LGALS3	ENSP00000254301³	STRING (score=.865)
TFAP2B	ENSP00000263046³	STRING (score=.821)
FYN	ENSP00000357656³	STRING (score=.755)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	TAS	8378324
GO:0009653	anatomical structure morphogenesis	TAS	8378324

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MCAM
2 Novoseek chemical compound relationships for MCAM gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cyclic amp	5.92	5	8616875 (4)
tyrosine	0.00	10	9756930 (3), 16004799 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MCAM)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006500

Sigma-Aldrich siRNA and siRNA Panels for MCAM

Sigma-Aldrich shRNA Panels and shRNA for MCAM

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006500

REFSEQ mRNAs for MCAM gene:

NM_006500.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006500

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006500
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006500
                                 untagged cDNA clone in CMV expression vector: NM_006500

Additional cDNA sequence:

AB209925.1 AF089868.1 AJ297452.1 AK126303.1 AK128335.1 AK291571.1 AK312430.1 BC056418.1

CR619421.1 CR625352.1 M28882.1 M29277.1

24/32 DOTS entries (see all 32 ):

DT.100829269 DT.120727722 DT.100647670 DT.95368635 DT.119361 DT.99926495 DT.120727667 DT.120727687

DT.95368622 DT.95123100 DT.100852916 DT.100800076 DT.120727637 DT.100647666 DT.120727609 DT.100812084

DT.100827619 DT.100863889 DT.120727613 DT.120727617 DT.120727640 DT.120727723 DT.91771719 DT.119363

24/417 AceView cDNA sequences (see all 417 ):

CD622804 BU726454 AA075411 CA406644 AL554839 AA301986 AU130835 BQ186858

BX355753 CB045248 CN484395 BM839729 CD622801 AI191503 BQ925298 AL548612

BQ917338 BM974622 M78206 AU119585 CK299961 BQ575580 W79542 BP372017

highest scoring ESTs for MCAM:

AF089868 AL541635 AL546898 AL548612 AL556415 AU100486 AU119585 AU130835 AU139007 AU139865

Unigene Cluster for MCAM:

Melanoma cell adhesion molecule

Hs.599039 [show with all ESTs]

Unigene Representative Sequence: AK126303

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for MCAM (see all 18 )

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	·	9d	·	9e	·	9f	^	10a	·	10b	·	10c	·	10d	^	11a	·	11b	^	12a	·
SP1:															-		-		-		-		-														-								-
SP2:															-		-		-		-		-				-										-								-
SP3:															-		-		-		-		-														-								-
SP4:									-		-		-		-		-		-		-		-														-								-
SP5:															-		-				-		-														-

ExUns:	12b	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18a	·	18b	^	19	^	20a	·	20b	^	21	^	22	^	23a	·	23b
SP1:																							-				-
SP2:																							-				-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for MCAM

2 Ensembl transcripts including schematic representations:

ENST00000264036 ENST00000392814

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MCAM expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MCAM

¹ / ² / ³

10 probe-sets matching MCAM gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
87991_at²^{, 3}	U95-E	1	0.69	1.00	1.00	1.00	AA155914	0.60	1.00	0.82	1
797_at*²^{, 3}	U95-A	1	--	--	-0.54	0.17	X68264	0.20	1.00	0.72	1
210869_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M29277	0.80	1.00	0.91	1
209086_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE964361	0.40	1.00	0.76	1
211340_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M28882	0.60	1.00	0.82	1
209087_x_at²^{, 3}	U133-A	2	1.00	0.95	--	--	AF089868	0.80	1.00	0.91	1
210869_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209086_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211340_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209087_x_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks MCAM for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGGATTAAAG

SOURCE GeneReport for Unigene cluster: Hs.599039
Expression variation in blood from EXPOLDB for MCAM
UniProtKB/Swiss-Prot: MUC18_HUMAN, P43121
Tissue specificity: Detected in endothelial cells in vascular tissue throughout the body. May
appear at the surface of neural crest cells during their embryonic migration. Appears to be
limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and
the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic
lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and
thin primary melanomas with a low probability of metastasis

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MCAM gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MCAM¹	--	melanoma cell adhesion molecule	83.95(n) 81.21(a)	489368 XM_546486.2 XP_546486.2
chimpanzee (Pan troglodytes)	MCAM¹	--	melanoma cell adhesion molecule	99.31(n) 98.88(a)	744688 XM_001149681.1 XP_001149681.1
cow (Bos taurus)	MCAM¹	--	melanoma cell adhesion molecule	85.82(n) 81.79(a)	281301 XM_586044.3 XP_586044.3
rat (Rattus norvegicus)	Mcam¹	--	melanoma cell adhesion molecule	81.27(n) 75.54(a)	78967 NM_023983.3 NP_076473.2
mouse (Mus musculus)	Mcam^{1, 5}	9⁵	melanoma cell adhesion molecule^{1, 5}	80.8(n)¹ 76.63(a)¹	84004¹ NM_023061.1¹ NP_075548.1¹ AB035508⁵ AB035509⁵ (see all 20)

About this table Species with no ortholog for MCAM

ENSEMBL Gene Tree for MCAM

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MCAM gene

BCAM² ALCAM²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/48 NCBI SNPs in MCAM are shown (see all 48 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 53)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7914^1,2	C,F,H,O	118685526(-)	`TCTTGC/TAGAAC`	1	--	ut3¹ ese³		19		MN EA NA EU WA	3002
	rs13699^1,2	A,F,H	118684862(-)	`TGGGCG/ACTGTT`	1	--	ut3¹ ese³		5		MN EU EA WA	556
	rs1893267^1,2	A,F,H	118684854(-)	`GTTTTC/TGAGTT`	1	--	ut3¹		3		EU EA	300
--	rs11033^1,2	A,F	118684889(-)	`aaagaT/CaCGTG`	1	--	ut3¹ ese³		2		MN	372
--	rs1131467^1,2	A,F	118684888(-)	`AAGATG/ACGTGC`	1	--	ut3¹ ese³		1		MN	184
	rs2511842^1,2	C,H	118694795(-)	`GAGACG/AAATCC`	1	--	ng3¹		4		EU EA WA	412
	rs34587557^1,2	F	118690887(+)	`GCTGCT/CCGTAC`	1	G/E	mis¹		1		NA	78
	rs12787894^1,2	H	118684685(+)	`GAGCTT/CGGTTT`	1	--	ut3¹		4		EU EA WA	418
	rs13700^1,2	F	118684760(-)	`GAGCAG/TACAAA`	1	--	ut3¹ ese³		1		MN	184
--	rs1893268^1,2	A	118684827(-)	`AATCCC/GCCGTG`	1	--	ut3¹ ese³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for MCAM (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 155735

10/16 Novoseek disease relationships for MCAM gene (see all 16 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
melanoma	73.53	82	16969099 (4), 9398060 (3), 15610525 (3), 8616875 (3) (see all 34)
metastatic melanoma	69.14	10	9810513 (2), 15610525 (1), 8959342 (1), 9187135 (1) (see all 8)
cell damage	54.68	7	15567448 (2), 15356072 (1), 18160586 (1), 15897668 (1) (see all 5)
metastasis	50.19	20	14695161 (3), 10362144 (2), 14980717 (2), 7923217 (2) (see all 10)
tumors	37.47	53	19123925 (7), 14695161 (4), 7923217 (4), 10951239 (2) (see all 16)
renal failure chronic	33.19	2	15356072 (2)
prostate carcinoma	28.71	1	18196513 (1)
lung metastases	28.22	1	10362144 (1)
inflammation	27.75	9	17175317 (1), 17982057 (1), 18160586 (1), 19229070 (1) (see all 5)
nevi	22.20	3	8959342 (1), 9187135 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/110 PubMed articles for MCAM gene (see all 110 ):

MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily. (PubMed id 2602381)^{2, 3, 4} Lehmann J.M.... Johnson J.P. (1989)
The progression associated antigen MUC18: a unique member of the immunoglobulin supergene family. (PubMed id 8292890)^{1, 3, 4} Johnson J.P.... Sers C. (1993)
Genomic organization of the melanoma-associated glycoprotein MUC18: implications for the evolution of the immunoglobulin domains. (PubMed id 8378324)^{1, 3, 4} Sers C.... Johnson J.P. (1993)
Assignment of the human melanoma cell adhesion molecule gene (MCAM) to chromosome 11 band q23.3 by radiation hybrid mapping. (PubMed id 10702685)^{1, 2, 3} Kuske M.D. and Johnson J.P. (1999)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification and functional assessment of endothelial P1H12. (PubMed id 11709656)^{3, 4} Solovey A.N....Hebbel R.P. (2001)
Outside-in signaling pathway linked to CD146 engagement in human endothelial cells. (PubMed id 11036077)^{3, 4} Anfosso F....Dignat-George F. (2001)
Identification of the S-endo 1 endothelial-associated antigen. (PubMed id 8573133)^{3, 4} Bardin N....Sampol J. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4162	HGNC: 6934	AceView: MCAM	Ensembl:ENSG00000076706	euGenes: HUgn4162
ECgene: MCAM	H-InvDB: MCAM

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MCAM	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for MCAM
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MCAM:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MCAM-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MCAM		Antibodies for MCAM
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MCAM		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MCAM)
	Antibodies (MCAM)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (CD146)
	Antibodies (CD146)

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Search Tocris compounds for MCAM

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Antibodies for MCAM

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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MCAM Gene at Home site.
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MCAM Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for MCAM

Summaries
for MCAM

Genomic Location
for MCAM

Proteins
for MCAM

Protein Domains/
Families
for MCAM

Gene Function
for MCAM

Pathways & Interactions
for MCAM

Drugs & Compounds
for MCAM

Transcripts
for MCAM

Expression
for MCAM

Orthologs
for MCAM

Paralogs
for MCAM

SNPs/Variants
for MCAM

Disorders & Mutations
for MCAM

Medical News
for MCAM

Publications
for MCAM

Search for MCAM

Genome Databases showing MCAM

Other Databases showing MCAM

Specialized Databases showing MCAM

Licensable Technologies
for MCAM

Services
for MCAM

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MCAM Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor MCAM

Summariesfor MCAM

Genomic Locationfor MCAM

Proteinsfor MCAM

Protein Domains/Familiesfor MCAM

Gene Functionfor MCAM

Pathways & Interactionsfor MCAM

Drugs & Compoundsfor MCAM

Transcriptsfor MCAM

Expression for MCAM

Orthologsfor MCAM

Paralogsfor MCAM

SNPs/Variantsfor MCAM

Disorders & Mutationsfor MCAM

Medical Newsfor MCAM

Publicationsfor MCAM

Search for MCAM

Genome Databases showing MCAM

Other Databases showing MCAM

Specialized Databases showing MCAM

Licensable Technologiesfor MCAM

Servicesfor MCAM

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MCAM

Summaries
for MCAM

Genomic Location
for MCAM

Proteins
for MCAM

Protein Domains/
Families
for MCAM

Gene Function
for MCAM

Pathways & Interactions
for MCAM

Drugs & Compounds
for MCAM

Transcripts
for MCAM

Expression
for MCAM

Orthologs
for MCAM

Paralogs
for MCAM

SNPs/Variants
for MCAM

Disorders & Mutations
for MCAM

Medical News
for MCAM

Publications
for MCAM

Licensable Technologies
for MCAM

Services
for MCAM