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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MCAM Gene

protein-coding   GIFtS: 57
GCID: GC11M119179

melanoma cell adhesion molecule
 Explore 38 diseases affiliated with
MCAM via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MCAM    

Aliases
for MCAM gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Melanoma Cell Adhesion Molecule1 2 3     S-Endo 1 Endothelial-Associated Antigen2 3
MUC181 2 3     Gicerin2
CD1461 2     Cell Surface Glycoprotein MUC182
Cell Surface Glycoprotein P1H122 3     Melanoma Adhesion Molecule2
Melanoma-Associated Antigen A322 3     CD146 Antigen3
Melanoma-Associated Antigen MUC182 3     

External Ids:    HGNC: 69341   Entrez Gene: 41622   Ensembl: ENSG000000767067   OMIM: 1557355   UniProtKB: P431213   

Export aliases for MCAM gene to outside databases

Previous GC identifers: GC11P121109 GC11M120690 GC11M119212 GC11M118716 GC11M118684 GC11M115119


Summaries
for MCAM gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MUC18_HUMAN, P43121
Function: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in
vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system,
thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during
embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a
transient increase in the intracellular calcium concentration

Gene Wiki entry for MCAM (CD146)


Genomic Views
for MCAM gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MCAM gene promoter:
         Max1   ER-alpha   Elk-1   p53   Nkx2-5   NF-kappaB   AREB6   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MCAM promoter sequence
   Search SABiosciences Chromatin IP Primers for MCAM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCAM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

MCAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCAM gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M119179:  view genomic region     (about GC identifiers)

Start:
 119,179,234 bp from pter      End:
 119,191,799 bp from pter
Size:
 12,566 bases      Orientation:
 minus strand

Proteins
for MCAM gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MUC18_HUMAN, P43121 (See protein sequence)
Recommended Name: Cell surface glycoprotein MUC18 precursor  
Size: 646 amino acids; 71607 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=BAD93162.1; Type=Erroneous initiation;
Secondary accessions: O95812 Q59E86 Q6PHR3 Q6ZTR2
Alternative splicing: 2 isoforms:  P43121-1   P43121-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MCAM: NX_P43121

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P43121

    • MCAM Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006491.2  
    ENSEMBL proteins: 
     ENSP00000264036   ENSP00000376561  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: MCAM
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    OriGene Custom Protein Services for MCAM 
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    Novus Biologicals MCAM Proteins
    Novus Biologicals MCAM Lysate
    Sino Biological Recombinant Protein for MCAM
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MCAM

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane NAS8378324
    GO:0009897external side of plasma membrane IDA--
    GO:0016021integral to membrane IEA--


    MCAM for ontologies           About GeneDecksing



    MCAM Antibody Products: 
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    Abcam antibodies for MCAM 
    Uscn Antibodies for MCAM
    ThermoFisher Antibodies for MCAM

    Assay Products for MCAM: 
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    Uscn ELISAs and CLIAs for MCAM

    Protein Domains /
    Families
    for MCAM gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MCAM for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR003598 Ig_sub2
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry P43121

    ProtoNet protein and cluster: P43121

    2 Blocks protein families:
    IPB003598 Immunoglobulin C-2 type
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: MUC18_HUMAN, P43121
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    Function
    for MCAM gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MUC18_HUMAN, P43121
    Function: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in
    vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system,
    thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during
    embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a
    transient increase in the intracellular calcium concentration

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCAM
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate MCAM (see all 15):
    hsa-miR-100* hsa-miR-3194-5p hsa-miR-624* hsa-miR-486-3p hsa-miR-410 hsa-miR-548aa hsa-miR-4260 hsa-miR-1251
    SwitchGear 3'UTR luciferase reporter plasmid: MCAM 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCAM (see all 7)
    OriGene shRNA RFP: MCAM
    OriGene siRNA: MCAM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MCAM

    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCAM 

    Cell Line
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    Search LifeMap BioReagents cell lines for MCAM

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCAM

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Mcam):
     cardiovascular system 

    MCAM for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MCAM gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MCAM

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/30 Interacting proteins for MCAM (P431212, 3 ENSP000002640364) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7IPQ6VMQ62, 3MINT-61905 I2D: score=3 
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    PTK2BQ142893, ENSP000003328164I2D: score=1 STRING: ENSP00000332816
    UBE2OQ9C0C93, ENSP000003236874I2D: score=1 STRING: ENSP00000323687
    ADAM10O146722MINT-8407185
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003094glomerular filtration IEP--
    GO:0007155cell adhesion IEA--
    GO:0009653anatomical structure morphogenesis TAS8378324
    GO:0061042vascular wound healing IEP--


    MCAM for ontologies           About GeneDecksing



    Drugs & Compounds
    for MCAM gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MCAM for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MCAM

    1 HMDB Compound for MCAM    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    2 Novoseek chemical compound relationships for MCAM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic amp 5.16 5 8616875 (4)
    tyrosine 0 10 9756930 (3), 16004799 (1)

    Search CenterWatch for drugs/clinical trials and news about MCAM / MUC18 

    Transcripts
    for MCAM gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MCAM gene: 
    NM_006500.2  

    Unigene Cluster for MCAM:

    Melanoma cell adhesion molecule
    Hs.599039  [show with all ESTs]
    Unigene Representative Sequence: AK126303
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000264036(uc001pwf.3) ENST00000528533 ENST00000525586 ENST00000527913(uc001pwg.1)
    ENST00000524940 ENST00000528976 ENST00000530706 ENST00000529257 ENST00000529295
    ENST00000530006 ENST00000530937 ENST00000528502 ENST00000529686 ENST00000526190
    ENST00000525555 ENST00000534522 ENST00000530144 ENST00000526992

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCAM
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate MCAM (see all 15):
    hsa-miR-100* hsa-miR-3194-5p hsa-miR-624* hsa-miR-486-3p hsa-miR-410 hsa-miR-548aa hsa-miR-4260 hsa-miR-1251
    SwitchGear 3'UTR luciferase reporter plasmid: MCAM 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MCAM (see all 7)
    OriGene shRNA RFP: MCAM
    OriGene siRNA: MCAM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MCAM
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MCAM (NM_006500)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCAM 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCAM
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCAM

    Additional cDNA sequence: 

    AB209925.1 AF089868.1 AJ297452.1 AK126303.1 AK128335.1 AK291571.1 AK312430.1 BC056418.1 
    M28882.1 M29277.1 

    24/31 DOTS entries (see all 31):

    DT.100829269  DT.120727722  DT.100647670  DT.95368635  DT.119361  DT.99926495  DT.120727667  DT.120727687 
    DT.95368622  DT.95123100  DT.100852916  DT.100800076  DT.120727637  DT.100647666  DT.120727609  DT.100827619 
    DT.100863889  DT.120727613  DT.120727617  DT.120727640  DT.120727723  DT.91771719  DT.100812084  DT.119363 

    24/417 AceView cDNA sequences (see all 417):

    CD622801 BQ184737 AA303432 AI470984 AI626006 AA302358 BE349495 BU146772 
    BQ186858 AI088654 AL548612 AU130835 AL549949 BP383662 AI094287 CR625352 
    BU174232 BQ917279 BM974622 BF475730 BM547347 H27357 AA303504 BC056418 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for MCAM (see all 18)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a ·
    SP1:                                            -     -     -     -     -                                         -                       -                     
    SP2:                                            -     -     -     -     -           -                             -                       -                     
    SP3:                                            -     -     -     -     -                                         -                       -                     
    SP4:                          -     -     -     -     -     -     -     -                                         -                       -                     
    SP5:                                            -     -           -     -                                         -                                             

    ExUns: 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b
    SP1:                                                                    -           -               
    SP2:                                                                    -           -               
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for MCAM

    Expression
    for MCAM gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MCAM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGATTAAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MCAM expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EndotheliumMicrovesselsPericytesPericytes
    Lateral Plate MesodermSplanchnic MesodermPericytesPericytes
    OvaryAntral FollicleCumulus CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    Endothelial-like cells (Generation of endoth...)
    Myofibroblasts/mesenchymal-like cells (Derivation of neural...)
    Expanded PAX7 cells (Generation of skelet...)

    See MCAM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MCAM

    SOURCE GeneReport for Unigene cluster: Hs.599039

    UniProtKB/Swiss-Prot: MUC18_HUMAN, P43121
    Tissue specificity: Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of
    neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult
    tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed
    most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi
    and thin primary melanomas with a low probability of metastasis

        SABiosciences Expression via Pathway-Focused PCR Arrays including MCAM: 
              Mesenchymal Stem Cell in human mouse rat
              Tumor Metastasis in human mouse rat

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCAM

    Orthologs
    for MCAM gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MCAM gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MCAM1 melanoma cell adhesion molecule 56.67(n)
    43.65(a)    		   448832  NM_001004768.1  NP_001004768.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MCAM6
    		 --
    		 32(a)
    		 1 ↔ 1
    		 GL343797.1(132741-148676)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005375461 cell surface glycoprotein MUC18-like 53.23(n)
    41.5(a)    		   100537546  XM_003198701.1  XP_003198749.1 


    ENSEMBL Gene Tree for MCAM (if available)
    TreeFam Gene Tree for MCAM (if available) 

    Paralogs
    for MCAM gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MCAM gene
    BCAM2  AGER2  ALCAM2  

    MCAM for paralogs           About GeneDecksing



    Genomic Variants
    for MCAM gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/240 NCBI SNPs in MCAM are shown (see all 240)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1868381571,2
    		--119179453(+) GCCCTC/TCTAGG 1 -- ut310--------
    rs1920047251,2
    		--119179464(+) GTTGGG/TGCCCT 1 -- ut310--------
    rs127878941,2
    		H--119179475(+) GAGCTT/CGGTTT 1 -- ut314Minor allele frequency- C:0.00NS EA 418
    rs589393661,2
    		C,--119179614(+) GAACAC/GGGGGG 1 -- ut313Minor allele frequency- G:0.13WA 122
    rs18932681,2
    		C,F,A,--119179617(-) AATCCC/GCCGTG 1 -- ut31 ese34Minor allele frequency- G:0.36CSA WA 123
    rs18932671,2
    		C,F,A,H,--119179644(-) GTTTTC/TGAGTT 1 -- ut3110Minor allele frequency- T:0.09NS EA NA WA CSA 548
    rs136991,2
    		C,F,A,H,--119179652(-) TGGGCG/ACTGTT 1 -- ut31 ese314Minor allele frequency- A:0.16MN NS EA NA WA CSA 807
    rs136121,2
    		--119179668(-) CCTGCG/AGTGAG 1 -- ut31 ese33Minor allele frequency- A:0.07MN CSA EA 306
    rs11314671,2
    		C,F,A,--119179678(-) AAGATG/ACGTGC 1 -- ut31 ese38Minor allele frequency- A:0.31MN WA NA CSA EA 550
    rs110331,2
    		C,A,--119179679(-) AAAGAC/TACGTG 1 -- ut31 ese37Minor allele frequency- T:0.49MN NA WA EA 734

    HapMap Linkage Disequilibrium report for MCAM (119179234 - 119191799 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MCAM: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MCAM
    DNA2.0 Custom Variant and Variant Library Synthesis for MCAM

    Disorders / Diseases
    for MCAM gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MCAM for disorders           About GeneDecksing

    OMIM gene information: 155735    OMIM disorders: --

    20/38 diseases for MCAM (see all 38):    About MalaCards
    placental site trophoblastic tumor    melanoma    epithelioid trophoblastic tumor    malignant pleural mesothelioma
    arteriosclerosis obliterans    sleep apnea    arteriosclerosis    apnea
    epithelial ovarian cancer    mucoepidermoid carcinoma    gallbladder adenocarcinoma    myopathy
    hyperuricemia    nephrotic syndrome    skin melanoma    myelofibrosis
    rheumatoid arthritis    melanoma metastasis    ovarian cancer    skin disease

    3 diseases from the University of Copenhagen DISEASES database for MCAM:
    Melanoma     Epithelioid trophoblastic tumor     Placental site trophoblastic tumor

    10/16 Novoseek disease relationships for MCAM gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 73.1 90 16969099 (4), 9398060 (3), 15610525 (3), 8616875 (3) (see all 35)
    metastatic melanoma 69.8 13 9810513 (2), 15610525 (1), 8959342 (1), 9187135 (1) (see all 9)
    cell damage 53.5 7 15567448 (2), 15356072 (1), 18160586 (1), 15897668 (1) (see all 5)
    metastasis 50.7 24 14695161 (3), 10362144 (2), 14980717 (2), 19703903 (2) (see all 11)
    tumors 36.9 56 19123925 (7), 14695161 (4), 7923217 (4), 10951239 (2) (see all 16)
    inflammation 34.1 12 20470278 (2), 17175317 (1), 17982057 (1), 18635422 (1) (see all 7)
    renal failure chronic 31.9 2 15356072 (2)
    prostate carcinoma 27.7 1 18196513 (1)
    lung metastases 26.9 1 10362144 (1)
    nevi 20.7 3 8959342 (1), 9187135 (1)


    Export disorders for MCAM gene to outside databases

    Publications
    for MCAM gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MCAM gene, integrated from 9 sources (see all 149):
    (articles sorted by number of sources associating them with MCAM)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily. (PubMed id 2602381)1, 2, 3 Lehmann J.M.... Johnson J.P. (1989)
    2. The progression associated antigen MUC18: a unique member of the immunoglobulin supergene family. (PubMed id 8292890)1, 2, 9 Johnson J.P.... Sers C. (1993)
    3. Genomic organization of the melanoma-associated glycoprotein MUC18: implications for the evolution of the immunoglobulin domains. (PubMed id 8378324)1, 2, 9 Sers C.... Johnson J.P. (1993)
    4. Assignment of the human melanoma cell adhesion molecule gene (MCAM) to chromosome 11 band q23.3 by radiation hybrid mapping. (PubMed id 10702685)1, 3, 9 Kuske M.D. and Johnson J.P. (1999)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Identification and functional assessment of endothelial P1H12. (PubMed id 11709656)1, 2 Solovey A.N....Hebbel R.P. (2001)
    8. Outside-in signaling pathway linked to CD146 engagement in human endothelial cells. (PubMed id 11036077)1, 2 Anfosso F....Dignat-George F. (2001)
    9. Identification of the S-endo 1 endothelial-associated antigen. (PubMed id 8573133)1, 2 Bardin N....Sampol J. (1996)
    10. Isolation and functional characterization of the A32 melanoma- associated antigen. (PubMed id 8162602)1, 2 Shih I.-M.... Herlyn M. (1994)

    External Searches for MCAM gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
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    Genome Databases showing MCAM gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4162 HGNC: 6934 AceView: MCAM Ensembl:ENSG00000076706 euGenes: HUgn4162
    ECgene: MCAM H-InvDB: MCAM

    Other Databases showing MCAM gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MCAM gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MCAM Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MCAM Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MCAM gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MCAM gene:
    Search GeneIP for patents involving MCAM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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