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MCAM Gene

protein-coding   GIFtS: 60
GCID: GC11M119179

Melanoma Cell Adhesion Molecule

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Melanoma Cell Adhesion Molecule1 2 3     S-Endo 1 Endothelial-Associated Antigen2 3
MUC182 3 5     CD1462 5
Gicerin1 2     Cell Surface Glycoprotein MUC182
Cell Surface Glycoprotein P1H122 3     Melanoma Adhesion Molecule2
Melanoma-Associated Antigen A322 3     CD146 Antigen3
Melanoma-Associated Antigen MUC182 3     

External Ids:    HGNC: 69341   Entrez Gene: 41622   Ensembl: ENSG000000767067   OMIM: 1557355   UniProtKB: P431213   

Export aliases for MCAM gene to outside databases

Previous GC identifers: GC11P121109 GC11M120690 GC11M119212 GC11M118716 GC11M118684 GC11M115119


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MCAM Gene:
MCAM (melanoma cell adhesion molecule) is a protein-coding gene. Diseases associated with MCAM include placental site trophoblastic tumor, and epithelioid trophoblastic tumor. An important paralog of this gene is BCAM.

UniProtKB/Swiss-Prot: MUC18_HUMAN, P43121
Function: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions
in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular
system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells
during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and
PTK2/FAK1, and a transient increase in the intracellular calcium concentration

Gene Wiki entry for MCAM (CD146) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MCAM gene promoter:
         Max1   ER-alpha   Elk-1   p53   Nkx2-5   NF-kappaB   AREB6   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMCAM promoter sequence
   Search Chromatin IP Primers for MCAM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MCAM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

MCAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCAM gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M119179:  view genomic region     (about GC identifiers)

Start:
119,179,234 bp from pter      End:
119,192,231 bp from pter
Size:
12,998 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MUC18_HUMAN, P43121 (See protein sequence)
Recommended Name: Cell surface glycoprotein MUC18 precursor  
Size: 646 amino acids; 71607 Da
Sequence caution: Sequence=BAD93162.1; Type=Erroneous initiation;
Secondary accessions: O95812 Q59E86 Q6PHR3 Q6ZTR2
Alternative splicing: 2 isoforms:  P43121-1   P43121-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MCAM: NX_P43121

Explore proteomics data for MCAM at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn56, Asn418, Asn449, Asn467, Asn508, Asn518, Asn527, Asn544
  • Modification sites at PhosphoSitePlus

  • See MCAM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006491.2  
    ENSEMBL proteins: 
     ENSP00000264036   ENSP00000376561  

    MCAM Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MCAM
    OriGene Protein Over-expression Lysate for MCAM
    OriGene MassSpec for MCAM
    OriGene Custom Protein Services for MCAM
    GenScript Custom Purified and Recombinant Proteins Services for MCAM
    Novus Biologicals MCAM Protein
    Novus Biologicals MCAM Lysate
    Sino Biological Recombinant Protein for MCAM
    Sino Biological Cell Lysate for MCAM
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MCAM

    MCAM Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MCAM
    R&D Systems Antibodies for MCAM (MCAM/CD146)
    OriGene Antibodies for MCAM
    OriGene Custom Antibody Services for MCAM
    Novus Biologicals MCAM Antibodies
    Abcam antibodies for MCAM
    Cloud-Clone Corp. Antibodies for MCAM
    ThermoFisher Antibodies for MCAM
    LSBio Antibodies in human, mouse, rat for MCAM

    MCAM Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MCAM
    R&D Systems Proteome Profiler Antibody Arrays for MCAM (MCAM/CD146)
    GenScript Custom Assay Services for MCAM
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MCAM
    Cloud-Clone Corp. CLIAs for MCAM


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    Selected InterPro protein domains (see all 7):
     IPR003598 Ig_sub2
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry P43121

    ProtoNet protein and cluster: P43121

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: MUC18_HUMAN, P43121
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    MCAM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MUC18_HUMAN, P43121
    Function: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions
    in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular
    system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells
    during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and
    PTK2/FAK1, and a transient increase in the intracellular calcium concentration

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    MCAM for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mcam):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system  no phenotypic analysis 

    MCAM for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MCAM: Mcamtm1Pyu Mcamtm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MCAM
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MCAM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MCAM
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MCAM

    miRNA
    Products:
        
    miRTarBase miRNAs that target MCAM:
    hsa-mir-124-3p (MIRT022381), hsa-mir-155-5p (MIRT020604), hsa-mir-192-5p (MIRT026263), hsa-mir-1 (MIRT023581), hsa-mir-215-5p (MIRT024589)

    Block miRNA regulation of human, mouse, rat MCAM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MCAM (see all 15):
    hsa-miR-100* hsa-miR-3194-5p hsa-miR-624* hsa-miR-486-3p hsa-miR-410 hsa-miR-548aa hsa-miR-4260 hsa-miR-1251
    SwitchGear 3'UTR luciferase reporter plasmidMCAM 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MCAM
    Predesigned siRNA for gene silencing in human, mouse, rat MCAM

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MCAM

    Clone
    Products:
         
    OriGene clones in human, mouse for MCAM (see all 5)
    OriGene ORF clones in mouse, rat for MCAM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MCAM (NM_006500)
    Sino Biological Human cDNA Clone for MCAM
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCAM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCAM

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MCAM
    Browse ESI BIO Cell Lines and PureStem Progenitors for MCAM 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCAM


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MUC18_HUMAN, P43121: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    extracellular2
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane NAS8378324
    GO:0009897external side of plasma membrane IDA--
    GO:0016021integral component of membrane IEA--

    MCAM for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including MCAM: 
              Mesenchymal Stem Cell in human mouse rat
              Tumor Metastasis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MCAM

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for MCAM (P431212, 3 ENSP000002640364) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7IPQ6VMQ62, 3MINT-61905 I2D: score=3 
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    PTK2BQ142893, ENSP000003328164I2D: score=1 STRING: ENSP00000332816
    UBE2OQ9C0C93, ENSP000003236874I2D: score=1 STRING: ENSP00000323687
    ADAM10O146722MINT-8407185
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003094glomerular filtration IEP--
    GO:0007155cell adhesion IEA--
    GO:0009653anatomical structure morphogenesis TAS8378324
    GO:0061042vascular wound healing IEP--

    MCAM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MCAM (MUC18)

    1 HMDB Compound for MCAM    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 Novoseek inferred chemical compound relationships for MCAM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic amp 5.16 5 8616875 (4)
    tyrosine 0 10 9756930 (3), 16004799 (1)



    MCAM for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MCAM gene: 
    NM_006500.2  

    Unigene Cluster for MCAM:

    Melanoma cell adhesion molecule
    Hs.599039  [show with all ESTs]
    Unigene Representative Sequence: AK126303
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264036(uc001pwf.3) ENST00000528533 ENST00000525586 ENST00000524940
    ENST00000528976 ENST00000530706 ENST00000529257 ENST00000529295 ENST00000530006
    ENST00000530937 ENST00000528502 ENST00000529686 ENST00000526190 ENST00000525555
    ENST00000534522 ENST00000530144 ENST00000526992 ENST00000392814
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MCAM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MCAM (see all 15):
    hsa-miR-100* hsa-miR-3194-5p hsa-miR-624* hsa-miR-486-3p hsa-miR-410 hsa-miR-548aa hsa-miR-4260 hsa-miR-1251
    SwitchGear 3'UTR luciferase reporter plasmidMCAM 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MCAM
    Predesigned siRNA for gene silencing in human, mouse, rat MCAM
    Clone
    Products:
         
    OriGene clones in human, mouse for MCAM (see all 5)
    OriGene ORF clones in mouse, rat for MCAM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MCAM (NM_006500)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCAM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCAM
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MCAM
    OriGene qSTAR qPCR primer pairs in human, mouse for MCAM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MCAM
      QuantiTect SYBR Green Assays in human, mouse, rat MCAM
      QuantiFast Probe-based Assays in human, mouse, rat MCAM

    Additional mRNA sequence: 

    AB209925.1 AF089868.1 AJ297452.1 AK126303.1 AK128335.1 AK291571.1 AK312430.1 BC056418.1 
    M28882.1 M29277.1 

    Selected DOTS entries (see all 31):

    DT.100829269  DT.120727722  DT.100647670  DT.95368635  DT.119361  DT.99926495  DT.120727667  DT.120727687 
    DT.95368622  DT.95123100  DT.100852916  DT.100800076  DT.120727637  DT.100647666  DT.120727609  DT.100812084 
    DT.100827619  DT.100863889  DT.120727613  DT.120727617  DT.120727640  DT.120727723  DT.91771719  DT.119363 

    Selected AceView cDNA sequences (see all 417):

    BQ881010 AA302361 N48880 BQ917338 BU174232 BU947658 BX355753 BQ224399 
    H27357 BQ917279 BQ575580 BM839729 AA303432 CA434640 BG055788 CB043935 
    BQ878001 CD622804 AI191503 AL545925 BM820486 AL554839 AL569913 BP364922 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MCAM (see all 18)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a ·
    SP1:                                            -     -     -     -     -                                         -                       -                     
    SP2:                                            -     -     -     -     -           -                             -                       -                     
    SP3:                                            -     -     -     -     -                                         -                       -                     
    SP4:                          -     -     -     -     -     -     -     -                                         -                       -                     
    SP5:                                            -     -           -     -                                         -                                             

    ExUns: 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b
    SP1:                                                                    -           -               
    SP2:                                                                    -           -               
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for MCAM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MCAM expression in normal human tissues (normalized intensities)      MCAM embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGATTAAAG
    MCAM Expression
    About this image


    MCAM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 23) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 11 entries
             Dental Pulp Stem Cells Dental Pulp
             Stem cells from human exfoliated deciduous teeth
     
     Mesenchymal Stem Cells
             Bone Marrow Stromal Cells Bone Marrow
     
     Endothelium (Cardiovascular System)    fully expand to see all 5 entries
             Pericytes Microvessels
             Human umbilical vein endothelial cells (HUVEC)
             Endothelial-like cells
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow Stromal Cells Bone Marrow
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow Stromal Cells Bone Marrow
    MCAM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MCAM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.599039

    UniProtKB/Swiss-Prot: MUC18_HUMAN, P43121
    Tissue specificity: Detected in endothelial cells in vascular tissue throughout the body. May appear at the
    surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle
    in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant
    melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected
    in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MCAM: 
              Mesenchymal Stem Cell in human mouse rat
              Tumor Metastasis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MCAM
    OriGene qSTAR qPCR primer pairs in human, mouse for MCAM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MCAM
    QuantiTect SYBR Green Assays in human, mouse, rat MCAM
    QuantiFast Probe-based Assays in human, mouse, rat MCAM
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCAM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MCAM gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mcam1 , 5 melanoma cell adhesion molecule1, 5 80.75(n)1
    76.47(a)1
      9 (24.68 cM)5
    840041  NM_023061.21  NP_075548.21 
     441344695 
    chicken
    (Gallus gallus)
    Aves MCAM1 melanoma cell adhesion molecule 56.67(n)
    43.65(a)
      448832  NM_001004768.1  NP_001004768.1 
    lizard
    (Anolis carolinensis)
    Reptilia MCAM6
    melanoma cell adhesion molecule
    31(a)
    1 ↔ 1
    GL343797.1(132681-148676)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mcam1 melanoma cell adhesion molecule 49.06(n)
    38.77(a)
      100489907  XM_004916046.1  XP_004916103.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018847301 cell surface glycoprotein MUC18-like 50.45(n)
    38.31(a)
      101884730  XM_005172015.1  XP_005172072.1 


    ENSEMBL Gene Tree for MCAM (if available)
    TreeFam Gene Tree for MCAM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MCAM gene
    BCAM2  ALCAM2  

    MCAM for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MCAM (see all 349)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1868381571,2
    --119179453(+) GCCCTC/TCTAGG 1 -- ut310--------
    rs1920047251,2
    --119179464(+) GTTGGG/TGCCCT 1 -- ut310--------
    rs127878941,2
    H--119179475(+) GAGCTT/CGGTTT 1 -- ut314Minor allele frequency- C:0.00NS EA 418
    rs589393661,2
    C,F--119179614(+) GAACAC/GGGGGG 1 -- ut313Minor allele frequency- G:0.13WA 122
    rs18932681,2
    C,F,A--119179617(-) AATCCC/GCCGTG 1 -- ut31 ese34Minor allele frequency- G:0.36CSA WA 123
    rs18932671,2
    C,F,A,H--119179644(-) GTTTTC/TGAGTT 1 -- ut3110Minor allele frequency- T:0.09NS EA NA WA CSA 548
    rs136991,2
    C,F,A,H--119179652(-) TGGGCG/ACTGTT 1 -- ut31 ese314Minor allele frequency- A:0.16MN NS EA NA WA CSA 807
    rs136121,2
    C,F--119179668(-) CCTGCG/AGTGAG 1 -- ut31 ese33Minor allele frequency- A:0.07MN CSA EA 306
    rs11314671,2
    C,F,A--119179678(-) AAGATG/ACGTGC 1 -- ut31 ese38Minor allele frequency- A:0.31MN WA NA CSA EA 550
    rs110331,2
    C,F,A--119179679(-) AAAGAC/TACGTG 1 -- ut31 ese37Minor allele frequency- T:0.49MN NA WA EA 734

    HapMap Linkage Disequilibrium report for MCAM (119179234 - 119192231 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MCAM:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv898417CNV Loss21882294
    nsv898418CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MCAM
    DNA2.0 Custom Variant and Variant Library Synthesis for MCAM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 155735    OMIM disorders: --

    Selected diseases for MCAM (see all 38):    About MalaCards
    placental site trophoblastic tumor    epithelioid trophoblastic tumor    gallbladder adenocarcinoma    melanoma
    arteriosclerosis obliterans    mucoepidermoid carcinoma    skin melanoma    arteriosclerosis
    hyperuricemia    malignant pleural mesothelioma    myelofibrosis    sleep apnea
    endotheliitis    nephrotic syndrome    diabetic nephropathy    esophageal cancer
    peritonitis    clear cell renal cell carcinoma    skin disease    choriocarcinoma

    3 diseases from the University of Copenhagen DISEASES database for MCAM:
    Melanoma     Epithelioid trophoblastic tumor     Placental site trophoblastic tumor

    MCAM for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for MCAM gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 73.1 90 16969099 (4), 9398060 (3), 15610525 (3), 8616875 (3) (see all 35)
    metastatic melanoma 69.8 13 9810513 (2), 15610525 (1), 8959342 (1), 9187135 (1) (see all 9)
    cell damage 53.5 7 15567448 (2), 15356072 (1), 18160586 (1), 15897668 (1) (see all 5)
    metastasis 50.7 24 14695161 (3), 10362144 (2), 14980717 (2), 19703903 (2) (see all 11)
    tumors 36.9 56 19123925 (7), 14695161 (4), 7923217 (4), 10951239 (2) (see all 16)
    inflammation 34.1 12 20470278 (2), 17175317 (1), 17982057 (1), 18635422 (1) (see all 7)
    renal failure chronic 31.9 2 15356072 (2)
    prostate carcinoma 27.7 1 18196513 (1)
    lung metastases 26.9 1 10362144 (1)
    nevi 20.7 3 8959342 (1), 9187135 (1)


    Export disorders for MCAM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MCAM gene, integrated from 10 sources (see all 165):
    (articles sorted by number of sources associating them with MCAM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily. (PubMed id 2602381)1, 2, 3 Lehmann J.M.... Johnson J.P. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    2. The progression associated antigen MUC18: a unique member of the immunoglobulin supergene family. (PubMed id 8292890)1, 2, 9 Johnson J.P.... Sers C. (Melanoma Res. 1993)
    3. Genomic organization of the melanoma-associated glycoprotein MUC18: implications for the evolution of the immunoglobulin domains. (PubMed id 8378324)1, 2, 9 Sers C.... Johnson J.P. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    4. Assignment of the human melanoma cell adhesion molecule gene (MCAM) to chromosome 11 band q23.3 by radiation hybrid mapping. (PubMed id 10702685)1, 3, 9 Kuske M.D. and Johnson J.P. (Cytogenet. Cell Genet. 1999)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Identification and functional assessment of endothelial P1H12. (PubMed id 11709656)1, 2 Solovey A.N....Hebbel R.P. (J. Lab. Clin. Med. 2001)
    8. Outside-in signaling pathway linked to CD146 engagement in human endothelial cells. (PubMed id 11036077)1, 2 Anfosso F....Dignat-George F. (J. Biol. Chem. 2001)
    9. Identification of the S-endo 1 endothelial-associated antigen. (PubMed id 8573133)1, 2 Bardin N....Sampol J. (Biochem. Biophys. Res. Commun. 1996)
    10. Isolation and functional characterization of the A32 melanoma- associated antigen. (PubMed id 8162602)1, 2 Shih I.-M.... Herlyn M. (Cancer Res. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4162 HGNC: 6934 AceView: MCAM Ensembl:ENSG00000076706 euGenes: HUgn4162
    ECgene: MCAM H-InvDB: MCAM

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MCAM Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MCAM Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MCAM gene:
    Search GeneIP for patents involving MCAM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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