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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MCAM Gene

protein-coding   GIFtS: 59
GCID: GC11M119179

Melanoma Cell Adhesion Molecule

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Melanoma Cell Adhesion Molecule1 2 3     S-Endo 1 Endothelial-Associated Antigen2 3
Gicerin1 2     CD1462
Cell Surface Glycoprotein P1H122 3     Cell Surface Glycoprotein MUC182
Melanoma-Associated Antigen A322 3     Melanoma Adhesion Molecule2
Melanoma-Associated Antigen MUC182 3     CD146 Antigen3
MUC182 3     

External Ids:    HGNC: 69341   Entrez Gene: 41622   Ensembl: ENSG000000767067   OMIM: 1557355   UniProtKB: P431213   

Export aliases for MCAM gene to outside databases

Previous GC identifers: GC11P121109 GC11M120690 GC11M119212 GC11M118716 GC11M118684 GC11M115119


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MCAM Gene: 
MCAM (melanoma cell adhesion molecule) is a protein-coding gene. Diseases associated with MCAM include placental site trophoblastic tumor, and epithelioid trophoblastic tumor. An important paralog of this gene is BCAM.

UniProtKB/Swiss-Prot: MUC18_HUMAN, P43121
Function: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions
in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular
system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells
during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and
PTK2/FAK1, and a transient increase in the intracellular calcium concentration

Gene Wiki entry for MCAM (CD146) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MCAM gene promoter:
         Max1   ER-alpha   Elk-1   p53   Nkx2-5   NF-kappaB   AREB6   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMCAM promoter sequence
   Search SABiosciences Chromatin IP Primers for MCAM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MCAM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

MCAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MCAM gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M119179:  view genomic region     (about GC identifiers)

Start:
119,179,234 bp from pter      End:
119,192,231 bp from pter
Size:
12,998 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MUC18_HUMAN, P43121 (See protein sequence)
Recommended Name: Cell surface glycoprotein MUC18 precursor  
Size: 646 amino acids; 71607 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=BAD93162.1; Type=Erroneous initiation;
Secondary accessions: O95812 Q59E86 Q6PHR3 Q6ZTR2
Alternative splicing: 2 isoforms:  P43121-1   P43121-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MCAM: NX_P43121

Explore proteomics data for MCAM at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P43121

  • MCAM Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MCAM Protein Expression
    REFSEQ proteins: NP_006491.2  
    ENSEMBL proteins: 
     ENSP00000264036   ENSP00000376561  

    Human Recombinant Protein Products for MCAM: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MCAM
    OriGene Protein Over-expression Lysate for MCAM
    OriGene MassSpec for MCAM 
    OriGene Custom Protein Services for MCAM
    GenScript Custom Purified and Recombinant Proteins Services for MCAM
    Novus Biologicals MCAM Proteins
    Novus Biologicals MCAM Lysate
    Sino Biological Recombinant Protein for MCAM
    Sino Biological Cell Lysate for MCAM 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MCAM 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane NAS8378324
    GO:0009897external side of plasma membrane IDA--
    GO:0016021integral to membrane IEA--

    MCAM for ontologies           About GeneDecksing



    MCAM Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MCAM
    R&D Systems Antibodies for MCAM (MCAM/CD146)
    OriGene Antibodies for MCAM
    OriGene Custom Antibody Services for MCAM
    GenScript Custom Superior Antibodies Services for MCAM
    Novus Biologicals MCAM Antibodies
    Abcam antibodies for MCAM
    Cloud-Clone Corp. Antibodies for MCAM 
    ThermoFisher Antibodies for MCAM
    LSBio Antibodies in human, mouse, rat for MCAM 

    Assay Products for MCAM: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MCAM
    R&D Systems Proteome Profiler Antibody Arrays for MCAM (MCAM/CD146)
    GenScript Custom Assay Services for MCAM
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MCAM 
    Cloud-Clone Corp. CLIAs for MCAM


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5/7 InterPro protein domains (see all 7):
     IPR003598 Ig_sub2
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry P43121

    ProtoNet protein and cluster: P43121

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: MUC18_HUMAN, P43121
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    MCAM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MUC18_HUMAN, P43121
    Function: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions
    in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular
    system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells
    during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and
    PTK2/FAK1, and a transient increase in the intracellular calcium concentration

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    MCAM for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mcam):
     cardiovascular system  homeostasis/metabolism  immune system  no phenotypic analysis 

    MCAM for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MCAM: Mcamtm1Pyu Mcamtm1Lex

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MCAM 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MCAM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MCAM 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MCAM 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCAM
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate MCAM (see all 15):
    hsa-miR-100* hsa-miR-3194-5p hsa-miR-624* hsa-miR-486-3p hsa-miR-410 hsa-miR-548aa hsa-miR-4260 hsa-miR-1251
    SwitchGear 3'UTR luciferase reporter plasmidMCAM 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MCAM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MCAM

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: MCAM (NM_006500)
    Sino Biological Human cDNA Clone for MCAM
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCAM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCAM
    Sirion Biotech Customized lentivirus for stable overexpression of MCAM 
                         Customized lentivirus expression plasmids for stable overexpression of MCAM 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MCAM
    Search LifeMap BioReagents cell lines for MCAM
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCAM


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MCAM

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/30 Interacting proteins for MCAM (P431212, 3 ENSP000002640364) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7IPQ6VMQ62, 3MINT-61905 I2D: score=3 
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    PTK2BQ142893, ENSP000003328164I2D: score=1 STRING: ENSP00000332816
    UBE2OQ9C0C93, ENSP000003236874I2D: score=1 STRING: ENSP00000323687
    ADAM10O146722MINT-8407185
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003094glomerular filtration IEP--
    GO:0007155cell adhesion IEA--
    GO:0009653anatomical structure morphogenesis TAS8378324
    GO:0061042vascular wound healing IEP--

    MCAM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MCAM for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MCAM (MUC18)

    1 HMDB Compound for MCAM    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 Novoseek inferred chemical compound relationships for MCAM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic amp 5.16 5 8616875 (4)
    tyrosine 0 10 9756930 (3), 16004799 (1)

    Search CenterWatch for drugs/clinical trials and news about MCAM / MUC18

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MCAM gene: 
    NM_006500.2  

    Unigene Cluster for MCAM:

    Melanoma cell adhesion molecule
    Hs.599039  [show with all ESTs]
    Unigene Representative Sequence: AK126303
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264036(uc001pwf.3) ENST00000528533 ENST00000525586 ENST00000524940
    ENST00000528976 ENST00000530706 ENST00000529257 ENST00000529295 ENST00000530006
    ENST00000530937 ENST00000528502 ENST00000529686 ENST00000526190 ENST00000525555
    ENST00000534522 ENST00000530144 ENST00000526992 ENST00000392814
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MCAM
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate MCAM (see all 15):
    hsa-miR-100* hsa-miR-3194-5p hsa-miR-624* hsa-miR-486-3p hsa-miR-410 hsa-miR-548aa hsa-miR-4260 hsa-miR-1251
    SwitchGear 3'UTR luciferase reporter plasmidMCAM 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MCAM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MCAM
    Clone
    Products:
         
    OriGene clones in human, mouse for MCAM (see all 6)
    OriGene ORF clones in mouse, rat for MCAM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MCAM (NM_006500)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MCAM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MCAM
    Sirion Biotech Customized lentivirus for stable overexpression of MCAM 
                         Customized lentivirus expression plasmids for stable overexpression of MCAM 
    Primer
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    OriGene qPCR primer pairs and template standards for MCAM
    OriGene qSTAR qPCR primer pairs in human, mouse for MCAM
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MCAM
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MCAM
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCAM

    Additional mRNA sequence: 

    AB209925.1 AF089868.1 AJ297452.1 AK126303.1 AK128335.1 AK291571.1 AK312430.1 BC056418.1 
    M28882.1 M29277.1 

    24/31 DOTS entries (see all 31):

    DT.100829269  DT.120727722  DT.100647670  DT.95368635  DT.119361  DT.99926495  DT.120727667  DT.120727687 
    DT.95368622  DT.95123100  DT.100852916  DT.100800076  DT.120727637  DT.100647666  DT.120727609  DT.100812084 
    DT.100827619  DT.100863889  DT.120727613  DT.120727617  DT.120727640  DT.120727723  DT.91771719  DT.119363 

    24/417 AceView cDNA sequences (see all 417):

    CB045248 CN482381 BQ269696 AA303432 H27357 AA057324 AI088654 BX355753 
    AK128335 CA406644 BQ943054 AU126003 BP383662 N48880 CA434640 AI094287 
    BQ925298 BQ881010 BP372819 AL554839 BQ962590 AI061054 BQ677920 BU146772 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for MCAM (see all 18)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a ·
    SP1:                                            -     -     -     -     -                                         -                       -                     
    SP2:                                            -     -     -     -     -           -                             -                       -                     
    SP3:                                            -     -     -     -     -                                         -                       -                     
    SP4:                          -     -     -     -     -     -     -     -                                         -                       -                     
    SP5:                                            -     -           -     -                                         -                                             

    ExUns: 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b
    SP1:                                                                    -           -               
    SP2:                                                                    -           -               
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for MCAM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MCAM expression in normal human tissues (normalized intensities)      MCAM embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGATTAAAG
    MCAM Expression
    About this image


    MCAM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 11 entries
             Pericytes Microvessels
             Human umbilical vein endothelial cells (HUVEC)
             Endothelial-like cells ( Derivation and purification of endothelial precursor cells...
             Human Ovarian Microvascular Endothelial Cells (HOMEC)   
             huvec   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Stem Cells Subcutaneous White Adipose
             breast ; adipocytes   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow Stromal Cells Bone Marrow
     
     Breast
             breast ; myoepithelial cells   

    See MCAM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MCAM

    SOURCE GeneReport for Unigene cluster: Hs.599039

    UniProtKB/Swiss-Prot: MUC18_HUMAN, P43121
    Tissue specificity: Detected in endothelial cells in vascular tissue throughout the body. May appear at the
    surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle
    in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant
    melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected
    in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis

        SABiosciences Expression via Pathway-Focused PCR Arrays including MCAM: 
              Mesenchymal Stem Cell in human mouse rat
              Tumor Metastasis in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MCAM
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MCAM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MCAM gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mcam1 , 5 melanoma cell adhesion molecule1, 5 80.75(n)1
    76.47(a)1
      9 (24.68 cM)5
    840041  NM_023061.21  NP_075548.21 
     441344695 
    chicken
    (Gallus gallus)
    Aves MCAM1 melanoma cell adhesion molecule 56.67(n)
    43.65(a)
      448832  NM_001004768.1  NP_001004768.1 
    lizard
    (Anolis carolinensis)
    Reptilia MCAM6
    Uncharacterized protein
    32(a)
    1 ↔ 1
    GL343797.1(132681-148676)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005375461 cell surface glycoprotein MUC18-like 53.23(n)
    41.5(a)
      100537546  XM_003198701.1  XP_003198749.1 


    ENSEMBL Gene Tree for MCAM (if available)
    TreeFam Gene Tree for MCAM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MCAM gene
    BCAM2  ALCAM2  

    MCAM for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/349 SNPs in MCAM are shown (see all 349)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1868381571,2
    --119179453(+) GCCCTC/TCTAGG 1 -- ut310--------
    rs1920047251,2
    --119179464(+) GTTGGG/TGCCCT 1 -- ut310--------
    rs127878941,2
    H--119179475(+) GAGCTT/CGGTTT 1 -- ut314Minor allele frequency- C:0.00NS EA 418
    rs589393661,2
    C,F--119179614(+) GAACAC/GGGGGG 1 -- ut313Minor allele frequency- G:0.13WA 122
    rs18932681,2
    C,F,A--119179617(-) AATCCC/GCCGTG 1 -- ut31 ese34Minor allele frequency- G:0.36CSA WA 123
    rs18932671,2
    C,F,A,H--119179644(-) GTTTTC/TGAGTT 1 -- ut3110Minor allele frequency- T:0.09NS EA NA WA CSA 548
    rs136991,2
    C,F,A,H--119179652(-) TGGGCG/ACTGTT 1 -- ut31 ese314Minor allele frequency- A:0.16MN NS EA NA WA CSA 807
    rs136121,2
    C,F--119179668(-) CCTGCG/AGTGAG 1 -- ut31 ese33Minor allele frequency- A:0.07MN CSA EA 306
    rs11314671,2
    C,F,A--119179678(-) AAGATG/ACGTGC 1 -- ut31 ese38Minor allele frequency- A:0.31MN WA NA CSA EA 550
    rs110331,2
    C,F,A--119179679(-) AAAGAC/TACGTG 1 -- ut31 ese37Minor allele frequency- T:0.49MN NA WA EA 734

    HapMap Linkage Disequilibrium report for MCAM (119179234 - 119192231 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MCAM:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv898417CNV Loss21882294
    nsv898418CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 155735    OMIM disorders: --

    20/32 diseases for MCAM (see all 32):    About MalaCards
    placental site trophoblastic tumor    epithelioid trophoblastic tumor    melanoma    gallbladder adenocarcinoma
    arteriosclerosis obliterans    skin melanoma    arteriosclerosis    hyperuricemia
    mucoepidermoid carcinoma    malignant pleural mesothelioma    myelofibrosis    sleep apnea
    endotheliitis    nephrotic syndrome    esophageal cancer    peritonitis
    skin disease    choriocarcinoma    myopathy    periodontitis

    3 diseases from the University of Copenhagen DISEASES database for MCAM:
    Melanoma     Epithelioid trophoblastic tumor     Placental site trophoblastic tumor

    MCAM for disorders           About GeneDecksing

    10/16 Novoseek inferred disease relationships for MCAM gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 73.1 90 16969099 (4), 9398060 (3), 15610525 (3), 8616875 (3) (see all 35)
    metastatic melanoma 69.8 13 9810513 (2), 15610525 (1), 8959342 (1), 9187135 (1) (see all 9)
    cell damage 53.5 7 15567448 (2), 15356072 (1), 18160586 (1), 15897668 (1) (see all 5)
    metastasis 50.7 24 14695161 (3), 10362144 (2), 14980717 (2), 19703903 (2) (see all 11)
    tumors 36.9 56 19123925 (7), 14695161 (4), 7923217 (4), 10951239 (2) (see all 16)
    inflammation 34.1 12 20470278 (2), 17175317 (1), 17982057 (1), 18635422 (1) (see all 7)
    renal failure chronic 31.9 2 15356072 (2)
    prostate carcinoma 27.7 1 18196513 (1)
    lung metastases 26.9 1 10362144 (1)
    nevi 20.7 3 8959342 (1), 9187135 (1)


    Export disorders for MCAM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MCAM gene, integrated from 9 sources (see all 160):
    (articles sorted by number of sources associating them with MCAM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily. (PubMed id 2602381)1, 2, 3 Lehmann J.M.... Johnson J.P. (1989)
    2. The progression associated antigen MUC18: a unique member of the immunoglobulin supergene family. (PubMed id 8292890)1, 2, 9 Johnson J.P.... Sers C. (1993)
    3. Genomic organization of the melanoma-associated glycoprotein MUC18: implications for the evolution of the immunoglobulin domains. (PubMed id 8378324)1, 2, 9 Sers C.... Johnson J.P. (1993)
    4. Assignment of the human melanoma cell adhesion molecule gene (MCAM) to chromosome 11 band q23.3 by radiation hybrid mapping. (PubMed id 10702685)1, 3, 9 Kuske M.D. and Johnson J.P. (1999)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Identification and functional assessment of endothelial P1H12. (PubMed id 11709656)1, 2 Solovey A.N....Hebbel R.P. (2001)
    8. Outside-in signaling pathway linked to CD146 engagement in human endothelial cells. (PubMed id 11036077)1, 2 Anfosso F....Dignat-George F. (2001)
    9. Identification of the S-endo 1 endothelial-associated antigen. (PubMed id 8573133)1, 2 Bardin N....Sampol J. (1996)
    10. Isolation and functional characterization of the A32 melanoma- associated antigen. (PubMed id 8162602)1, 2 Shih I.-M.... Herlyn M. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4162 HGNC: 6934 AceView: MCAM Ensembl:ENSG00000076706 euGenes: HUgn4162
    ECgene: MCAM H-InvDB: MCAM

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MCAM Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MCAM Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MCAM gene:
    Search GeneIP for patents involving MCAM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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