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MC5R Gene

protein-coding   GIFtS: 61
GCID: GC18P013815

Melanocortin 5 Receptor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Melanocortin 5 Receptor1 2
MC22
Melanocortin Receptor 52
Melanocortin-5 Receptor2
MC-23
MC5-R3

External Ids:    HGNC: 69331   Entrez Gene: 41612   Ensembl: ENSG000001761367   OMIM: 6000425   UniProtKB: P330323   

Export aliases for MC5R gene to outside databases

Previous GC identifers: GC18M013920 GC18P013911


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MC5R Gene:
This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family
that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and
adrenocorticotropic hormone and is suggested to play a role in sebum generation. (provided by RefSeq, Jun 2010)

GeneCards Summary for MC5R Gene:
MC5R (melanocortin 5 receptor) is a protein-coding gene. Diseases associated with MC5R include obesity, association with, and morbid obesity. GO annotations related to this gene include hormone binding and melanocortin receptor activity. An important paralog of this gene is CNR1.

UniProtKB/Swiss-Prot: MC5R_HUMAN, P33032
Function: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G
proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation
properties of melanocortins

summary for MC5R Gene:
Melanocortin receptors are activated by members of the melanocortin family: alpha-, beta- and
gamma-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). Endogenous antagonists
include agouti and agouti-related protein (AgRP). The melanocortin receptors are G-protein-coupled and 5
subtypes exist, MC1-5. The melanocortins are involved in a wide range of physiological functions, including
pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis and temperature control.

Gene Wiki entry for MC5R (Melanocortin 5 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NC_018929.2  NT_010859.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the MC5R gene promoter:
         CRE-BP1   AREB6   PPAR-gamma1   AML1a   SEF-1 (1)   PPAR-gamma2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMC5R promoter sequence
   Search Chromatin IP Primers for MC5R

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MC5R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.2   Ensembl cytogenetic band:  18p11.21   HGNC cytogenetic band: 18p11.2

MC5R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MC5R gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P013815:  view genomic region     (about GC identifiers)

Start:
13,824,154 bp from pter      End:
13,826,861 bp from pter
Size:
2,708 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MC5R_HUMAN, P33032 (See protein sequence)
Recommended Name: Melanocortin receptor 5  
Size: 325 amino acids; 36601 Da
Secondary accessions: B0YJ34 Q502V1

Explore the universe of human proteins at neXtProt for MC5R: NX_P33032

Explore proteomics data for MC5R at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn2, Asn15, Asn20, Asn28

  • See MC5R Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005904.1  
    ENSEMBL proteins: 
     ENSP00000468086   ENSP00000318077  
    Reactome Protein details: P33032

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MCNR: GPCR / Class A : Melanocortin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: MC5 receptor
    Melanocortin receptors

    5 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000621 Melancort_rcpt_5
     IPR001671 Melcrt_ACTH_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR001908 Melancort_rcpt

    Graphical View of Domain Structure for InterPro Entry P33032

    ProtoNet protein and cluster: P33032

    3 Blocks protein domains:
    IPB000621 Melanocortin 5 receptor signature
    IPB001671 Melanocortin receptor family signature
    IPB001908 Melanocortin receptor signature


    UniProtKB/Swiss-Prot: MC5R_HUMAN, P33032
    Similarity: Belongs to the G-protein coupled receptor 1 family


    MC5R for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MC5R_HUMAN, P33032
    Function: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G
    proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation
    properties of melanocortins

         Genatlas biochemistry entry for MC5R:
    melanocortin receptor 5,expressed in brain,G protein coupled receptor superfamily

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004977melanocortin receptor activity IEA--
    GO:0005515protein binding IPI19329486
    GO:0042562hormone binding IEA--
         
    MC5R for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mc5r):
     behavior/neurological  endocrine/exocrine gland  homeostasis/metabolism  integument  vision/eye 

    MC5R for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mc5rtm1Cone for MC5R

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MC5R
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MC5R

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MC5R
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MC5R

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    GenScript: all cDNA clones in your preferred vector: MC5R (NM_005913)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MC5R

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MC5R


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MC5R_HUMAN, P33032: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7739752
    GO:0016021integral component of membrane ----

    MC5R for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MC5R About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    4G alpha (s) signalling events
    G alpha (s) signalling events
    5Adenylate cyclase activating neuropeptides
    Adenylate cyclase activating neuropeptides

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for MC5R
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for MC5R
        Peptide ligand-binding receptors
    G alpha (s) signalling events


    1 Kegg Pathway  (Kegg details for MC5R):
        Neuroactive ligand-receptor interaction


    MC5R for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MC5R: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MC5R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MC5R (P330323 ENSP000003180774) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGRPO002533, ENSP000002909534I2D: score=1 STRING: ENSP00000290953
    POMCP011893, ENSP000002647084I2D: score=3 STRING: ENSP00000264708
    ASIPP421273, ENSP000003640924I2D: score=1 STRING: ENSP00000364092
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY6ENSP000003114054STRING: ENSP00000311405
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS7739752
    GO:0030819positive regulation of cAMP biosynthetic process IDA19329486

    MC5R for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MC5R available from Tocris Bioscience    About this table
    CompoundAction CAS #
    [D-Trp8]-gamma-MSHSelective MC3 receptor agonist[321351-81-9]
    PG 106Selective MC3 receptor antagonist[944111-22-2]
    alpha-MSHEndogenous melanocortin receptor agonist[581-05-5]
    SHU 9119 MC3 and MC4 antagonist, MC5 partial agonist [168482-23-3]
    HS 014Selective MC4 receptor antagonist[207678-81-7]

    9 IUPHAR Ligands for MC5R (MC5 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    PG-901
    AgonistFull agonist10.512431055
    SHU9119
    AgonistPartial agonist910657491
    NDP-MSH
    AgonistFull agonist912007532
    MT-II
    AgonistFull agonist912007532
    [125I]NDP-MSH
    AgonistFull agonist8.615840392
    HS024
    AntagonistAntagonist8.59832440
    Ac-c[Cys-Glu-His-D-Phe-Arg-Trp-D-Cys]-Pro-Pro-Lys-Asp-NH2
    AntagonistAntagonist812904077
    alpha-MSH
    AgonistFull agonist6.912007532
    agouti-related protein
    AntagonistInverse agonist6.59892020

    4 Novoseek inferred chemical compound relationships for MC5R gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alpha msh 74.1 2 17539827 (1), 17376561 (1)
    shu 9119 73.1 1 17127674 (1)
    acth 67.5 6 19743876 (1), 14694081 (1), 12644303 (1), 17584128 (1) (see all 5)
    lipid 1.01 6 19915133 (3), 16309786 (1), 12851311 (1)



    MC5R for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MC5R gene: 
    NM_005913.2  

    Unigene Cluster for MC5R:

    Melanocortin 5 receptor
    Hs.248145  [show with all ESTs]
    Unigene Representative Sequence: BC095531
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589410 ENST00000324750(uc010xaf.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat MC5R

    Additional mRNA sequence: 

    BC069153.1 BC069545.1 BC095531.1 

    1 DOTS entry:

    DT.102819854 

    4 AceView cDNA sequences:

    BC069545 NM_005913 BC069153 CF147775 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MC5R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCACTTCA
    MC5R Expression
    About this image


    MC5R expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Hair (Integumentary System)
             Sebocytes Sebaceous Gland
    MC5R Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MC5R Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248145

    UniProtKB/Swiss-Prot: MC5R_HUMAN, P33032
    Tissue specificity: Expressed in the brain but not in the melanoma cells

        Pathway & Disease-focused RT2 Profiler PCR Array including MC5R: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
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    OriGene qSTAR qPCR primer pairs in human, mouse for MC5R
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MC5R
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    QuantiFast Probe-based Assays in human, mouse, rat MC5R
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MC5R

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MC5R gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mc5r1 , 5 melanocortin 5 receptor1, 5 81.92(n)1
    81.82(a)1
      18 (41.46 cM)5
    172031  NM_013596.21  NP_038624.21 
     683376035 
    chicken
    (Gallus gallus)
    Aves MC5R1 melanocortin 5 receptor 74.28(n)
    78.09(a)
      421047  NM_001031015.1  NP_001026186.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mc5r1 melanocortin 5 receptor 69.14(n)
    77.16(a)
      100124993  NM_001102922.1  NP_001096392.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mc5ra2 melanocortin 5a receptor 75.8(n)   286834  NM_173279.1 


    ENSEMBL Gene Tree for MC5R (if available)
    TreeFam Gene Tree for MC5R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for MC5R gene
    CNR12  GPR122  LPAR22  S1PR12  CNR22  S1PR32  S1PR22  LPAR12  
    MC1R2  MC3R2  GPR32  MC2R2  MC4R2  S1PR42  GPR62  LPAR32  
    S1PR52  
    10 SIMAP similar genes for MC5R using alignment to 2 protein entries:     MC5R_HUMAN (see all proteins):
    MC3R    MC4R    LOC441453    LPAR2    OR51E2    MC1R
    MC2R    EDG2    LPAR1    ADORA2A

    MC5R for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MC5R (see all 152)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438171511,2
    C,Funtested113826364(+) TTCCTA/C/TCTGGT 2 L syn11NA 4552
    rs1446217061,2
    C--13823574(+) AGCAAA/CCACCC 1 -- us2k10--------
    rs1163768961,2
    C,F--13823643(+) TCAACC/AAACCA 1 -- us2k13Minor allele frequency- A:0.09WA NA EA 358
    rs1383749851,2
    --13823652(+) CAAGGA/TACCAC 1 -- us2k10--------
    rs1416432781,2
    C--13823671(+) CCAAT-/CAACGAAC 1 -- us2k10--------
    rs1157017321,2
    C,F--13823789(+) ACCACC/TCAACC 1 -- us2k12Minor allele frequency- T:0.12WA EA 238
    rs96756531,2
    A--13823801(+) accaaA/Gcaagc 1 -- us2k10--------
    rs72399321,2
    C--13823866(+) cactcA/Taccaa 1 -- us2k14Minor allele frequency- T:0.16WA NA EA 360
    rs1880923681,2
    --13823893(+) GCAACC/GACTCA 1 -- us2k10--------
    rs1489141371,2
    --13823923(+) GACCGA/GCCGAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MC5R (13824154 - 13826861 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MC5R:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv909413CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MC5R
    DNA2.0 Custom Variant and Variant Library Synthesis for MC5R

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600042    OMIM disorders: --

    11 diseases for MC5R:    
    About MalaCards
    obesity, association with    morbid obesity    anorexia nervosa    atopic dermatitis
    obesity    bipolar disorder    dermatitis    schizophrenia
    melanoma    neuronitis    hepatitis


    MC5R for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for MC5R gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 20.8 2 10078851 (2)

    Genetic Association Database (GAD): MC5R
    Human Genome Epidemiology (HuGE) Navigator: MC5R (11 documents)

    Export disorders for MC5R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MC5R gene, integrated from 10 sources (see all 71):
    (articles sorted by number of sources associating them with MC5R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression, candidate gene, and population studies of the melanocortin 5 receptor. (PubMed id 11286624)1, 2, 4, 9 Hatta N.... Rees J.L. (J. Invest. Dermatol. 2001)
    2. Molecular cloning of a novel human melanocortin receptor. (PubMed id 8396929)1, 2, 3 Chhajlani V.... Wikberg J.E.S. (Biochem. Biophys. Res. Commun. 1993)
    3. Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH. (PubMed id 9240466)1, 2, 9 Fraendberg P.-A.... Chhajlani V. (Biochem. Biophys. Res. Commun. 1997)
    4. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder. (PubMed id 19502010)1, 4 Miller C.L....Leonard S. (Schizophr. Res. 2009)
    7. Further evidence for the role of ENPP1 in obesity: association with morbid obesity in Finns. (PubMed id 18551113)1, 4 Valli-Jaakola K....Kontula K. (Obesity (Silver Spring) 2008)
    8. Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder. (PubMed id 16314755)1, 4 Lohoff F.W. and Berrettini W.H. (Psychiatr. Genet. 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype. (PubMed id 7739752)1, 2 Fathi Z.... Parker E.M. (Neurochem. Res. 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4161 HGNC: 6933 AceView: MC5R Ensembl:ENSG00000176136 euGenes: HUgn4161
    ECgene: MC5R Kegg: 4161 H-InvDB: MC5R

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MC5R Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Melanocortin_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MC5R gene:
    Search GeneIP for patents involving MC5R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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