Aliases for MC5R Gene
External Ids for MC5R Gene
Previous GeneCards Identifiers for MC5R Gene
This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010]
GeneCards Summary for MC5R Gene
MC5R (Melanocortin 5 Receptor) is a Protein Coding gene. Diseases associated with MC5R include obesity. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include hormone binding and melanocortin receptor activity. An important paralog of this gene is LPAR1.
UniProtKB/Swiss-Prot for MC5R Gene
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins
Melanocortin receptors are activated by members of the melanocortin family: alpha-, beta- and gamma-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). Endogenous antagonists include agouti and agouti-related protein (AgRP). The melanocortin receptors are G-protein-coupled and 5 subtypes exist, MC1-5. The melanocortins are involved in a wide range of physiological functions, including pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis and temperature control.