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Aliases for MC5R Gene

Aliases for MC5R Gene

  • Melanocortin 5 Receptor 2 3
  • Melanocortin-5 Receptor 3
  • MC5-R 4
  • MC-2 4
  • MC2 3

External Ids for MC5R Gene

Previous GeneCards Identifiers for MC5R Gene

  • GC18M013920
  • GC18P013911

Summaries for MC5R Gene

Entrez Gene Summary for MC5R Gene

  • This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010]

GeneCards Summary for MC5R Gene

MC5R (Melanocortin 5 Receptor) is a Protein Coding gene. Diseases associated with MC5R include obesity. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and melanocortin receptor activity. An important paralog of this gene is LPAR1.

UniProtKB/Swiss-Prot for MC5R Gene

  • Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins

Tocris Summary for MC5R Gene

  • Melanocortin receptors are activated by members of the melanocortin family: alpha-, beta- and gamma-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). The melanocortins are involved in a range of physiological functions, including pigmentation and inflammation.

Gene Wiki entry for MC5R Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MC5R Gene

Genomics for MC5R Gene

Regulatory Elements for MC5R Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MC5R Gene

Chromosome:
18
Start:
13,824,155 bp from pter
End:
13,826,862 bp from pter
Size:
2,708 bases
Orientation:
Plus strand

Genomic View for MC5R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MC5R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MC5R Gene

Proteins for MC5R Gene

  • Protein details for MC5R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33032-MC5R_HUMAN
    Recommended name:
    Melanocortin receptor 5
    Protein Accession:
    P33032
    Secondary Accessions:
    • B0YJ34
    • Q502V1

    Protein attributes for MC5R Gene

    Size:
    325 amino acids
    Molecular mass:
    36601 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MC5R Gene

Proteomics data for MC5R Gene at MOPED

Post-translational modifications for MC5R Gene

  • Glycosylation at Asn 2, Asn 15, Asn 20, and Asn 28
  • Modification sites at PhosphoSitePlus

Other Protein References for MC5R Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for MC5R (Melanocortin-5 R/MC5R)

No data available for DME Specific Peptides for MC5R Gene

Domains & Families for MC5R Gene

Gene Families for MC5R Gene

Suggested Antigen Peptide Sequences for MC5R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P33032

UniProtKB/Swiss-Prot:

MC5R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with MC5R: view

Function for MC5R Gene

Molecular function for MC5R Gene

GENATLAS Biochemistry:
melanocortin receptor 5,expressed in brain,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins

Gene Ontology (GO) - Molecular Function for MC5R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004977 melanocortin receptor activity IEA --
GO:0005515 protein binding IPI 19329486
GO:0042562 hormone binding IEA --
genes like me logo Genes that share ontologies with MC5R: view
genes like me logo Genes that share phenotypes with MC5R: view

Animal Models for MC5R Gene

MGI Knock Outs for MC5R:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MC5R

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for MC5R Gene

Localization for MC5R Gene

Subcellular locations from UniProtKB/Swiss-Prot for MC5R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MC5R Gene COMPARTMENTS Subcellular localization image for MC5R gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for MC5R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7739752
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with MC5R: view

Pathways & Interactions for MC5R Gene

genes like me logo Genes that share pathways with MC5R: view

Pathways by source for MC5R Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for MC5R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MC5R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 7739752
GO:0030819 positive regulation of cAMP biosynthetic process IDA 19329486
genes like me logo Genes that share ontologies with MC5R: view

Drugs & Compounds for MC5R Gene

(12) Drugs for MC5R Gene - From: IUPHAR, DGIdb, NovoSeek, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>125</sup>I]NDP-MSH Pharma Full agonist, Agonist 0
Ac-c[Cys-Glu-His-D-Phe-Arg-Trp-D-Cys]-Pro-Pro-Lys-Asp-NH<sub>2</sub> Pharma Antagonist 0
agouti-related protein Pharma Inverse agonist, Antagonist 0
HS024 Pharma Antagonist 0
MT-II Pharma Full agonist, Agonist 0

(7) Additional Compounds for MC5R Gene - From: NovoSeek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NDP-MSH
Full agonist, Agonist
[Nle4,D-Phe7]-alpha-MSH
75921-69-6
Melanocyte-stimulating hormone release inhibiting factor
2002-44-0
Melanotan II
121062-08-6
Alpha msh
genes like me logo Genes that share compounds with MC5R: view

Transcripts for MC5R Gene

mRNA/cDNA for MC5R Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MC5R Gene

Melanocortin 5 receptor:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MC5R

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MC5R Gene

No ASD Table

Relevant External Links for MC5R Gene

GeneLoc Exon Structure for
MC5R
ECgene alternative splicing isoforms for
MC5R

Expression for MC5R Gene

mRNA expression in normal human tissues for MC5R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MC5R Gene

This gene is overexpressed in Esophagus - Mucosa (x10.4), Testis (x7.2), and Skin - Not Sun Exposed (Suprapubic) (x5.5).

Protein differential expression in normal tissues from HIPED for MC5R Gene

This gene is overexpressed in Liver (61.9) and Pancreatic juice (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MC5R Gene



SOURCE GeneReport for Unigene cluster for MC5R Gene Hs.248145

mRNA Expression by UniProt/SwissProt for MC5R Gene

P33032-MC5R_HUMAN
Tissue specificity: Expressed in the brain but not in the melanoma cells
genes like me logo Genes that share expression patterns with MC5R: view

Protein tissue co-expression partners for MC5R Gene

Primer Products

In Situ Assay Products

Orthologs for MC5R Gene

This gene was present in the common ancestor of chordates.

Orthologs for MC5R Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MC5R 35
  • 82.1 (n)
  • 79.94 (a)
MC5R 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MC5R 35
  • 85.83 (n)
  • 87.81 (a)
MC5R 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mc5r 35
  • 81.92 (n)
  • 81.82 (a)
Mc5r 16
Mc5r 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MC5R 35
  • 99.18 (n)
  • 99.38 (a)
rat
(Rattus norvegicus)
Mammalia Mc5r 35
  • 82.72 (n)
  • 81.48 (a)
oppossum
(Monodelphis domestica)
Mammalia MC5R 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MC5R 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves MC5R 35
  • 74.28 (n)
  • 78.09 (a)
MC5R 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mc5r 35
  • 69.14 (n)
  • 77.16 (a)
zebrafish
(Danio rerio)
Actinopterygii mc5ra 35
  • 72.48 (n)
  • 77.52 (a)
mc5ra 36
  • 70 (a)
OneToMany
mc5rb 36
  • 67 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
ManyToMany
-- 36
  • 17 (a)
ManyToMany
Species with no ortholog for MC5R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MC5R Gene

ENSEMBL:
Gene Tree for MC5R (if available)
TreeFam:
Gene Tree for MC5R (if available)

Paralogs for MC5R Gene

(10) SIMAP similar genes for MC5R Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MC5R: view

Variants for MC5R Gene

Sequence variations from dbSNP and Humsavar for MC5R Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs1293453 -- 13,824,943(-) CATAC(A/G)TGTTA upstream-variant-2KB
rs1541276 -- 13,825,728(-) AAATT(G/T)ACTGT utr-variant-5-prime
rs2236699 -- 13,826,008(+) GTGGC(A/G/T)GACAT synonymous-codon, reference
rs2236700 - 13,826,392(+) ATGTT(C/G)CTCCT reference, missense
rs2236701 -- 13,826,509(+) TTTAC(C/T)GTGTG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MC5R Gene

Variant ID Type Subtype PubMed ID
nsv909413 CNV Gain 21882294

Variation tolerance for MC5R Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.99; 87.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MC5R Gene

HapMap Linkage Disequilibrium report
MC5R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MC5R Gene

Disorders for MC5R Gene

MalaCards: The human disease database

(1) MalaCards diseases for MC5R Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
obesity
  • obesity, association with
- elite association
Search MC5R in MalaCards View complete list of genes associated with diseases

Relevant External Links for MC5R

Genetic Association Database (GAD)
MC5R
Human Genome Epidemiology (HuGE) Navigator
MC5R
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MC5R
genes like me logo Genes that share disorders with MC5R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MC5R Gene

Publications for MC5R Gene

  1. Increased alpha-melanocyte-stimulating hormone (alpha-MSH) levels and melanocortin receptors expression associated with pigmentation in an NC/Nga mouse model of atopic dermatitis. (PMID: 19889022) Hiramoto K. … Inoue M. (Exp. Dermatol. 2010) 23 67
  2. Novel binding motif of ACTH analogues at the melanocortin receptors. (PMID: 19743876) Yang Y. … Harmon C.M. (Biochemistry 2009) 23 67
  3. The melanocortin system in articular chondrocytes: melanocortin receptors, pro-opiomelanocortin, precursor proteases, and a regulatory effect of alpha-melanocyte-stimulating hormone on proinflammatory cytokines and extracellular matrix components. (PMID: 19790046) GrAossel S. … BAPhm M. (Arthritis Rheum. 2009) 23 67
  4. Demonstration of the proopiomelanocortin signaling system in the primary immune organ of the quail. (PMID: 19456381) Kobayashi T. … Machida T. (Ann. N. Y. Acad. Sci. 2009) 23 67
  5. Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking. (PMID: 19535343) Sebag J.A. … Hinkle P.M. (J. Biol. Chem. 2009) 23 67

Products for MC5R Gene

Sources for MC5R Gene

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