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Aliases for MC5R Gene

Aliases for MC5R Gene

  • Melanocortin 5 Receptor 2 3 5
  • Melanocortin-5 Receptor 3
  • MC5-R 4
  • MC-2 4
  • MC2 3

External Ids for MC5R Gene

Previous GeneCards Identifiers for MC5R Gene

  • GC18M013920
  • GC18P013911

Summaries for MC5R Gene

Entrez Gene Summary for MC5R Gene

  • This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010]

GeneCards Summary for MC5R Gene

MC5R (Melanocortin 5 Receptor) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and melanocortin receptor activity. An important paralog of this gene is MC4R.

UniProtKB/Swiss-Prot for MC5R Gene

  • Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

Tocris Summary for MC5R Gene

  • Melanocortin receptors are activated by members of the melanocortin family: alpha-, beta- and gamma-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). The melanocortins are involved in a range of physiological functions, including pigmentation and inflammation.

Gene Wiki entry for MC5R Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MC5R Gene

Genomics for MC5R Gene

Regulatory Elements for MC5R Gene

Enhancers for MC5R Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MC5R on UCSC Golden Path with GeneCards custom track

Promoters for MC5R Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MC5R on UCSC Golden Path with GeneCards custom track

Genomic Location for MC5R Gene

13,824,155 bp from pter
13,826,862 bp from pter
2,708 bases
Plus strand

Genomic View for MC5R Gene

Genes around MC5R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MC5R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MC5R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MC5R Gene

Proteins for MC5R Gene

  • Protein details for MC5R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanocortin receptor 5
    Protein Accession:
    Secondary Accessions:
    • B0YJ34
    • Q502V1

    Protein attributes for MC5R Gene

    325 amino acids
    Molecular mass:
    36601 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MC5R Gene

Proteomics data for MC5R Gene at MOPED

Post-translational modifications for MC5R Gene

  • Glycosylation at Asn 2, Asn 15, Asn 20, and Asn 28
  • Modification sites at PhosphoSitePlus

Other Protein References for MC5R Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for MC5R (Melanocortin-5 R/MC5R)

No data available for DME Specific Peptides for MC5R Gene

Domains & Families for MC5R Gene

Gene Families for MC5R Gene

Suggested Antigen Peptide Sequences for MC5R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with MC5R: view

Function for MC5R Gene

Molecular function for MC5R Gene

GENATLAS Biochemistry:
melanocortin receptor 5,expressed in brain,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.
genes like me logo Genes that share phenotypes with MC5R: view

Animal Models for MC5R Gene

MGI Knock Outs for MC5R:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MC5R Gene

Localization for MC5R Gene

Subcellular locations from UniProtKB/Swiss-Prot for MC5R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MC5R Gene COMPARTMENTS Subcellular localization image for MC5R gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for MC5R Gene

Pathways & Interactions for MC5R Gene

genes like me logo Genes that share pathways with MC5R: view

SIGNOR curated interactions for MC5R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MC5R Gene


Drugs & Compounds for MC5R Gene

(12) Drugs for MC5R Gene - From: DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>125</sup>I]NDP-MSH Pharma Full agonist, Agonist 0
Ac-c[Cys-Glu-His-D-Phe-Arg-Trp-D-Cys]-Pro-Pro-Lys-Asp-NH<sub>2</sub> Pharma Antagonist 0
agouti-related protein Pharma Inverse agonist, Antagonist 0
HS024 Pharma Antagonist 0
MT-II Pharma Full agonist, Agonist 0

(7) Additional Compounds for MC5R Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Full agonist, Agonist
Melanotan II

(5) Tocris Compounds for MC5R Gene

Compound Action Cas Number
[Nle4,D-Phe7]-alpha-MSH Melanocortin receptor agonist 75921-69-6
alpha-MSH Endogenous melanocortin receptor agonist 581-05-5
gamma1-MSH Selective MC3 receptor agonist 72629-65-3
Melanotan II High affinity melanocortin receptor agonist 121062-08-6
THIQ Potent and selective MC4 receptor agonist 312637-48-2
genes like me logo Genes that share compounds with MC5R: view

Transcripts for MC5R Gene

mRNA/cDNA for MC5R Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MC5R Gene

Melanocortin 5 receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MC5R Gene

No ASD Table

Relevant External Links for MC5R Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MC5R Gene

mRNA expression in normal human tissues for MC5R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MC5R Gene

This gene is overexpressed in Esophagus - Mucosa (x10.4), Testis (x7.2), and Skin - Not Sun Exposed (Suprapubic) (x5.5).

Protein differential expression in normal tissues from HIPED for MC5R Gene

This gene is overexpressed in Liver (61.9) and Pancreatic juice (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MC5R Gene

SOURCE GeneReport for Unigene cluster for MC5R Gene Hs.248145

mRNA Expression by UniProt/SwissProt for MC5R Gene

Tissue specificity: Expressed in the brain but not in the melanoma cells.
genes like me logo Genes that share expression patterns with MC5R: view

Protein tissue co-expression partners for MC5R Gene

Primer Products

Orthologs for MC5R Gene

This gene was present in the common ancestor of chordates.

Orthologs for MC5R Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MC5R 35
  • 82.1 (n)
  • 79.94 (a)
MC5R 36
  • 80 (a)
(Canis familiaris)
Mammalia MC5R 35
  • 85.83 (n)
  • 87.81 (a)
MC5R 36
  • 86 (a)
(Mus musculus)
Mammalia Mc5r 35
  • 81.92 (n)
  • 81.82 (a)
Mc5r 16
Mc5r 36
  • 70 (a)
(Pan troglodytes)
Mammalia MC5R 35
  • 99.18 (n)
  • 99.38 (a)
(Rattus norvegicus)
Mammalia Mc5r 35
  • 82.72 (n)
  • 81.48 (a)
(Monodelphis domestica)
Mammalia MC5R 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia MC5R 36
  • 74 (a)
(Gallus gallus)
Aves MC5R 35
  • 74.28 (n)
  • 78.09 (a)
MC5R 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mc5r 35
  • 69.14 (n)
  • 77.16 (a)
(Danio rerio)
Actinopterygii mc5ra 35
  • 72.48 (n)
  • 77.52 (a)
mc5ra 36
  • 70 (a)
mc5rb 36
  • 67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
-- 36
  • 17 (a)
Species with no ortholog for MC5R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MC5R Gene

Gene Tree for MC5R (if available)
Gene Tree for MC5R (if available)

Paralogs for MC5R Gene

Paralogs for MC5R Gene

(10) SIMAP similar genes for MC5R Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MC5R: view

Variants for MC5R Gene

Sequence variations from dbSNP and Humsavar for MC5R Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs2236700 - 13,826,392(+) ATGTT(C/G)CTCCT reference, missense
rs4797005 -- 13,824,149(+) CCCGC(A/G)GAGCC upstream-variant-2KB
rs4797006 -- 13,824,808(+) TGCTG(G/T)TTTTT upstream-variant-2KB
rs7239932 -- 13,823,867(+) cactc(A/T)accaa upstream-variant-2KB
rs8098942 -- 13,824,016(+) TTTTC(G/T)CTCGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MC5R Gene

Variant ID Type Subtype PubMed ID
nsv909413 CNV Gain 21882294

Variation tolerance for MC5R Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.99; 87.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MC5R Gene

Disorders for MC5R Gene

Relevant External Links for MC5R

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MC5R Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MC5R Gene

Publications for MC5R Gene

  1. Expression, candidate gene, and population studies of the melanocortin 5 receptor. (PMID: 11286624) Hatta N. … Rees J.L. (J. Invest. Dermatol. 2001) 3 4 23 48 67
  2. MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. (PMID: 19329486) Chan L.F. … Clark A.J. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  3. Melanocortin 5 receptor activates ERK1/2 through a PI3K-regulated signaling mechanism. (PMID: 19428994) Rodrigues A.R. … Gouveia A.M. (Mol. Cell. Endocrinol. 2009) 3 23
  4. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. (PMID: 17482720) Grieco P. … Hruby V.J. (Peptides 2007) 3 23
  5. Characterization of Agouti-related protein binding to melanocortin receptors. (PMID: 9892020) Yang Y.K. … Gantz I. (Mol. Endocrinol. 1999) 3 23

Products for MC5R Gene

Sources for MC5R Gene