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Aliases for MC5R Gene

Aliases for MC5R Gene

  • Melanocortin 5 Receptor 2 3
  • Melanocortin Receptor 5 3
  • Melanocortin-5 Receptor 3
  • MC5-R 4
  • MC-2 4
  • MC2 3

External Ids for MC5R Gene

Previous GeneCards Identifiers for MC5R Gene

  • GC18M013920
  • GC18P013911

Summaries for MC5R Gene

Entrez Gene Summary for MC5R Gene

  • This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010]

GeneCards Summary for MC5R Gene

MC5R (Melanocortin 5 Receptor) is a Protein Coding gene. Diseases associated with MC5R include obesity. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include hormone binding and melanocortin receptor activity. An important paralog of this gene is LPAR1.

UniProtKB/Swiss-Prot for MC5R Gene

  • Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins

Tocris Summary for MC5R Gene

  • Melanocortin receptors are activated by members of the melanocortin family: alpha-, beta- and gamma-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). Endogenous antagonists include agouti and agouti-related protein (AgRP). The melanocortin receptors are G-protein-coupled and 5 subtypes exist, MC1-5. The melanocortins are involved in a wide range of physiological functions, including pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis and temperature control.

Gene Wiki entry for MC5R Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MC5R Gene

Genomics for MC5R Gene

Regulatory Elements for MC5R Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MC5R Gene

13,824,155 bp from pter
13,826,862 bp from pter
2,708 bases
Plus strand

Genomic View for MC5R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MC5R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MC5R Gene

Proteins for MC5R Gene

  • Protein details for MC5R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanocortin receptor 5
    Protein Accession:
    Secondary Accessions:
    • B0YJ34
    • Q502V1

    Protein attributes for MC5R Gene

    325 amino acids
    Molecular mass:
    36601 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MC5R Gene

Proteomics data for MC5R Gene at MOPED

Post-translational modifications for MC5R Gene

  • Glycosylation at Asn2, Asn15, Asn20, and Asn28
  • Modification sites at PhosphoSitePlus

Other Protein References for MC5R Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for MC5R (Melanocortin-5 R/MC5R)

No data available for DME Specific Peptides for MC5R Gene

Domains for MC5R Gene

Gene Families for MC5R Gene

  • MCNR :GPCR / Class A : Melanocortin receptors

Suggested Antigen Peptide Sequences for MC5R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P33032
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with MC5R: view

Function for MC5R Gene

Molecular function for MC5R Gene

GENATLAS Biochemistry:
melanocortin receptor 5,expressed in brain,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins

Gene Ontology (GO) - Molecular Function for MC5R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004977 melanocortin receptor activity IEA --
GO:0005515 protein binding IPI 19329486
GO:0042562 hormone binding IEA --
genes like me logo Genes that share ontologies with MC5R: view
genes like me logo Genes that share phenotypes with MC5R: view

Animal Models for MC5R Gene

MGI Knock Outs for MC5R:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MC5R

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for MC5R Gene

Localization for MC5R Gene

Subcellular locations from UniProtKB/Swiss-Prot for MC5R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MC5R Gene COMPARTMENTS Subcellular localization image for MC5R gene
Compartment Confidence
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MC5R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7739752
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with MC5R: view

Pathways for MC5R Gene

genes like me logo Genes that share pathways with MC5R: view

Pathways by source for MC5R Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MC5R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 7739752
GO:0030819 positive regulation of cAMP biosynthetic process IDA 19329486
genes like me logo Genes that share ontologies with MC5R: view

Compounds for MC5R Gene

(5) Tocris Compounds for MC5R Gene

Compound Action Cas Number
[D-Trp8]-gamma-MSH Selective MC3 receptor agonist [321351-81-9]
[Nle4,D-Phe7]-alpha-MSH Melanocortin receptor agonist [75921-69-6]
ACTH (1-39) Potent endogenous MC2 agonist [12279-41-3]
BMS 470539 dihydrochloride Potent, selective MC1 receptor agonist [457893-92-4]
MCL 0020 Selective MC4 receptor antagonist [475498-26-1]

(9) IUPHAR Ligand for MC5R Gene

Ligand Type Action Affinity Pubmed IDs
NDP-MSH Agonist Full agonist 10
[125I]NDP-MSH Agonist Full agonist 9.5
MT-II Agonist Full agonist 9.4
agouti-related protein Antagonist Inverse agonist 9.3
SHU9119 Agonist Partial agonist 9.2
alpha-MSH Agonist Full agonist 8.4
PG-901 Antagonist Antagonist 8.1
Ac-c[Cys-Glu-His-D-Phe-Arg-Trp-D-Cys]-Pro-Pro-Lys-Asp-NH2 Antagonist Antagonist 8
HS024 Antagonist Antagonist 7.7

(4) Novoseek inferred chemical compound relationships for MC5R Gene

Compound -log(P) Hits PubMed IDs
alpha msh 74.1 2
shu 9119 73.1 1
acth 67.5 5
lipid 1.01 5
genes like me logo Genes that share compounds with MC5R: view

Transcripts for MC5R Gene

mRNA/cDNA for MC5R Gene

(4) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MC5R Gene

Melanocortin 5 receptor:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MC5R

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MC5R Gene

No ASD Table

Relevant External Links for MC5R Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MC5R Gene

mRNA expression in normal human tissues for MC5R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MC5R Gene

This gene is overexpressed in Esophagus - Mucosa (10.4), Testis (7.2), and Skin - Not Sun Exposed (Suprapubic) (5.5).

Protein differential expression in normal tissues for MC5R Gene

This gene is overexpressed in Liver (61.9) and Pancreatic juice (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MC5R Gene

SOURCE GeneReport for Unigene cluster for MC5R Gene Hs.248145

mRNA Expression by UniProt/SwissProt for MC5R Gene

Tissue specificity: Expressed in the brain but not in the melanoma cells
genes like me logo Genes that share expressions with MC5R: view

Expression partners for MC5R Gene

In Situ Assay Products

Orthologs for MC5R Gene

This gene was present in the common ancestor of chordates.

Orthologs for MC5R Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MC5R 35
  • 82.1 (n)
  • 79.94 (a)
MC5R 36
  • 80 (a)
(Canis familiaris)
Mammalia MC5R 35
  • 85.83 (n)
  • 87.81 (a)
MC5R 36
  • 86 (a)
(Mus musculus)
Mammalia Mc5r 35
  • 81.92 (n)
  • 81.82 (a)
Mc5r 16
Mc5r 36
  • 70 (a)
(Pan troglodytes)
Mammalia MC5R 35
  • 99.18 (n)
  • 99.38 (a)
(Rattus norvegicus)
Mammalia Mc5r 35
  • 82.72 (n)
  • 81.48 (a)
(Monodelphis domestica)
Mammalia MC5R 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia MC5R 36
  • 74 (a)
(Gallus gallus)
Aves MC5R 35
  • 74.28 (n)
  • 78.09 (a)
MC5R 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mc5r 35
  • 69.14 (n)
  • 77.16 (a)
(Danio rerio)
Actinopterygii mc5ra 35
  • 72.48 (n)
  • 77.52 (a)
mc5ra 36
  • 70 (a)
mc5rb 36
  • 67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
-- 36
  • 17 (a)
Species with no ortholog for MC5R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MC5R Gene

Gene Tree for MC5R (if available)
Gene Tree for MC5R (if available)

Paralogs for MC5R Gene

Selected SIMAP similar genes for MC5R Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MC5R: view

Variants for MC5R Gene

Sequence variations from dbSNP and Humsavar for MC5R Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs1293453 -- 13,824,943(-) CATAC(A/G)TGTTA upstream-variant-2KB
rs1541276 -- 13,825,728(-) AAATT(G/T)ACTGT utr-variant-5-prime
rs2236699 -- 13,826,008(+) GTGGC(G/T)GACAT reference, synonymous-codon
rs2236700 - 13,826,392(+) ATGTT(C/G)CTCCT reference, missense
rs2236701 -- 13,826,509(+) TTTAC(C/T)GTGTG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MC5R Gene

Variant ID Type Subtype PubMed ID
nsv909413 CNV Gain 21882294

Relevant External Links for MC5R Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MC5R Gene

Disorders for MC5R Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MC5R Gene in MalaCards »

(1) Diseases for MC5R Gene including...

(1) Novoseek inferred disease relationships for MC5R Gene

Disease -log(P) Hits PubMed IDs
obesity 20.8 2

Relevant External Links for MC5R

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MC5R: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for MC5R Gene

Publications for MC5R Gene

  1. Expression, candidate gene, and population studies of the melanocortin 5 receptor. (PMID: 11286624) Hatta N. … Rees J.L. (J. Invest. Dermatol. 2001) 3 4 23 48
  2. Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH. (PMID: 9240466) Fraendberg P.-A. … Chhajlani V. (Biochem. Biophys. Res. Commun. 1997) 3 4 23
  3. Molecular cloning of a novel human melanocortin receptor. (PMID: 8396929) Chhajlani V. … Wikberg J.E.S. (Biochem. Biophys. Res. Commun. 1993) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder. (PMID: 16314755) Lohoff F.W. … Berrettini W.H. (Psychiatr. Genet. 2005) 3 48

Products for MC5R Gene

Sources for MC5R Gene

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