MC4R Gene
protein-coding GIFtS: 61
GCID: GC18M058011
|
|
melanocortin 4 receptor
| |
Aliases
for MC4R gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Melanocortin 4 Receptor1 2 | | MC4-R2 3 | | Melanocortin Receptor 42 |
Export aliases for MC4R gene to outside databasesPrevious GC identifers: GC18M057869 GC18M056187 GC18M056189 GC18M054747 |
Summaries
for MC4R gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MC4R:
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. Theencoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is anintronless gene. Defects in this gene are a cause of autosomal dominant obesity. (provided by RefSeq, Jan 2010)
UniProtKB/Swiss-Prot: MC4R_HUMAN, P32245Function: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, andgamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase
 summary
for MC4R: Melanocortin receptors are activated by members of the melanocortin family: alpha-, beta- and
gamma-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). Endogenous antagonists
include agouti and agouti-related protein (AgRP). The melanocortin receptors are G-protein-coupled and 5
subtypes exist, MC1-5. The melanocortins are involved in a wide range of physiological functions, including
pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis and temperature control.
Gene Wiki entry for MC4R (Melanocortin 4 receptor)
|
Genomic Views
for MC4R gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_025028.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MC4R gene promoter:
TBP CREB POU2F1 POU2F1a deltaCREB ARP-1 POU6F1 (c2) Tal-1beta E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for MC4R
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MC4R |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q22 Ensembl cytogenetic band: 18q21.32 HGNC cytogenetic band: 18q22MC4R Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M058011: view genomic region
(about GC identifiers)
Start:
|
58,038,564 bp from pter |
End:
|
58,040,001 bp from pter |
Size:
|
1,438 bases |
Orientation:
|
minus strand |
|
Proteins
for MC4R gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MC4R_HUMAN, P32245 (See
protein sequence)Recommended Name: Melanocortin receptor 4 Size: 332 amino acids; 36943 Da
Subunit: Interacts with ATRNL1 (By similarity). Interacts with MGRN1, but does not undergo MGRN1-mediatedubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production
Subcellular location: Cell membrane; Multi-pass membrane protein
6 PDB 3D structures from  and Proteopedia  for MC4R:2IQP (3D)
2IQR (3D)
2IQS (3D)
2IQU (3D)
2IQV (3D)
2IQW (3D)
Secondary accessions: B2RAC3 Q16317 Q3MIJ6Explore the universe of human proteins at neXtProt for MC4R: NX_P32245
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P32245
MC4R Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005903.2
ENSEMBL proteins: ENSP00000299766 Reactome Protein details: P32245
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MC4R for ontologies About GeneDecksing
MC4R Antibody Products:
Assay Products for MC4R: |
Protein
Domains /
Families
for MC4R gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MC4R for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P32245ProtoNet protein and cluster: P32245 4 Blocks protein families: IPB000155 Melanocortin 4 receptor signature IPB000621 Melanocortin 5 receptor signature IPB001671 Melanocortin receptor family signature IPB001908 Melanocortin receptor signature
UniProtKB/Swiss-Prot: MC4R_HUMAN, P32245Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for MC4R gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MC4R_HUMAN, P32245Function: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, andgamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase Genatlas biochemistry entry for MC4R:melanocortin receptor 4,expressed in brain,placenta and intestinal tissue,G protein coupled receptorsuperfamily,involved in energy balance,but likely to be a minor contributor in obesity
Clone
Products: |  | EMD Millipore Clones for the Expression of MC4R | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MC4R (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MC4R
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MC4R (NM_005912) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MC4R | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MC4R |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MC4R |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
MC4R for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for MC4R: Mc4rtm1Lex Mc4rtm1Dhu
11 MGI mutant phenotypes (inferred from 7 alleles ) (MGI details for Mc4r):
MC4R for phenotypes About GeneDecksing
|
Pathways & Interactions
for MC4R gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | Adenylate cyclase-activating neuropeptides | | | 4 | Syndecan-3-mediated signaling events | | | 5 | Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for MC4R
3  BioSystems Pathways for MC4R
5/7 
Reactome Pathways for MC4R (see all 7)
1 
Kegg Pathway (Kegg details for MC4R):
MC4R for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MC4R
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/77 Interacting proteins for MC4R (P322453 ENSP000002997664) via UniProtKB, MINT, STRING, and/or I2D (see all 77)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002024 | diet induced thermogenesis |
IEA | -- | | GO:0006112 | energy reserve metabolic process |
IEA | -- | | GO:0007188 | adenylate cyclase-modulating G-protein coupled receptor signaling pathway |
TAS | 8794897 | | GO:0007631 | feeding behavior |
IEA | -- | | GO:0019222 | regulation of metabolic process |
-- | -- |
MC4R for ontologies About GeneDecksing
|
Drugs & Compounds
for MC4R gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MC4R for compounds About GeneDecksing
Compounds for MC4R available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| SHU 9119 | MC3 and MC4 antagonist, MC5 partial agonist | [168482-23-3] | | THIQ | Potent and selective MC4 receptor agonist | [312637-48-2] | | MCL 0020 | Selective MC4 receptor antagonist | [475498-26-1] | | JKC 363 | Potent and selective MC4 receptor antagonist | [436083-30-6] | | Melanotan II | High affinity melanocortin receptor agonist | [121062-08-6] |
10/29 Novoseek chemical compound relationships for MC4R gene (see all 29) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| shu 9119 |
87.5 |
17 |
12666176 (2), 9853124 (2), 15072565 (2), 12851307 (1) (see all 12) |
| mb-243 |
86.4 |
1 |
15582434 (1) |
| alpha msh |
77.8 |
5 |
16166226 (2), 9751529 (1), 14709157 (1) |
| acth |
57.9 |
15 |
19743876 (2), 14694081 (2), 8584883 (1), 9605554 (1) (see all 9) |
| piperidine |
24.7 |
3 |
17768046 (1), 16697186 (1) |
| tetrapeptide |
18.6 |
1 |
20304640 (1) |
| beta-alanine |
17.3 |
2 |
14643322 (2) |
| piperazine |
17.2 |
2 |
15317471 (1) |
| cocaine |
14.6 |
10 |
12490616 (4), 15597110 (1), 15340100 (1), 17440766 (1) |
| alanine |
11.9 |
1 |
9454589 (1) |
Search CenterWatch for drugs/clinical trials and news about MC4R
|
Transcripts
for MC4R gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MC4R gene: NM_005912.2 Unigene Cluster for MC4R: Melanocortin 4 receptor Hs.532833 [show with all ESTs]Unigene Representative Sequence: NM_0059121 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000299766(uc002lie.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MC4R (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MC4R
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MC4R (NM_005912) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MC4R | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MC4R |
Additional cDNA sequence: AK314130.1 BC069172.1 BC101802.1 BC111992.1 1 DOTS entry: DT.91848835 2 AceView cDNA sequences: BC069172 NM_005912
GeneLoc Exon Structure
|
Expression
for MC4R gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MC4R expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTAATTCAA
About this image
See MC4R Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MC4R
SOURCE GeneReport for Unigene cluster: Hs.532833
UniProtKB/Swiss-Prot: MC4R_HUMAN, P32245Tissue specificity: Brain, placental, and gut tissues
SABiosciences Expression via Pathway-Focused PCR Array including MC4R:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MC4R
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MC4R | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MC4R | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MC4R | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MC4R |
Orthologs
for MC4R gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MC4R gene from 3/11 species (see all 11) About this table
ENSEMBL Gene Tree for MC4R (if available)
TreeFam Gene Tree for MC4R (if available) |
Paralogs
for MC4R gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MC4R gene
- CNR12 GPR122 ENSG000002675342 LPAR22 CNR22 S1PR12 GPR32 MC2R2
- MC5R2 S1PR32 S1PR42 MC1R2 GPR62 LPAR12 MC3R2 LPAR32
- S1PR52
9 SIMAP similar genes for MC4R using alignment to 10 protein entries: MC4R_HUMAN (see all proteins):LOC441453 MC3R MC5R MC1R MC2R LPAR1
EDG2 HTR5A CHRM2
MC4R for paralogs About GeneDecksing
|
Genomic Variants
for MC4R gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MC4R (58038564 - 58040001 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MC4R: --
Human Gene Mutation Database (HGMD): MC4R
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MC4R |
|
Disorders
/ Diseases
for MC4R gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MC4R for disorders About GeneDecksing
OMIM gene information: 155541
OMIM disorders: 601665
UniProtKB/Swiss-Prot: MC4R_HUMAN, P32245
Defects in MC4R are a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increaseof body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation ofbody fat
20/28  diseases for MC4R (see all 28): About MalaCardsobesity attention deficit hyperactivity disorder obesity, autosomal dominant bulimia nervosa
eating disorder acth deficiency anorexia nervosa type 2 diabetes mellitus
autism spectrum disorder sleep apnea polycystic ovary syndrome insulin resistance
hyperandrogenism diabetes mellitus spinocerebellar ataxia morbid obesity
apnea hyperinsulinism obesity, association with gout
3 diseases from the University of Copenhagen DISEASES database for MC4R:Morbid obesity Diabetes mellitus Hyperinsulinism 10/18 Novoseek disease relationships for MC4R gene (see all 18) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| obesity |
83.2 |
440 |
10598807 (5), 16710097 (5), 16507637 (5), 19255736 (5) (see all 99) |
| obesity morbid |
56.9 |
7 |
10903341 (2), 17941900 (1), 10903343 (1), 10196693 (1) (see all 5) |
| binge eating disorder |
47.6 |
9 |
16030156 (5), 15585384 (1), 16094248 (1), 18777518 (1) |
| acth deficiency |
46.5 |
1 |
9620771 (1) |
| binge eating |
43.8 |
5 |
16507637 (2), 20305219 (1), 12646666 (1) |
| genetic susceptibility |
40 |
2 |
16083993 (1), 11397906 (1) |
| hyperandrogenism |
36.5 |
4 |
15533382 (2) |
| hyperinsulinemia |
30.3 |
6 |
18971258 (1), 15126516 (1), 10078568 (1), 19214805 (1) |
| anorexia nervosa |
29.5 |
1 |
10199800 (1) |
| insulin resistance |
21.1 |
13 |
18454146 (3), 19680233 (1), 19050674 (1), 11246450 (1) (see all 5) |
Genetic Association Database (GAD): MC4R
Human Genome Epidemiology (HuGE) Navigator: MC4R (148 documents)
Export disorders for MC4R gene to outside databases
|
Publications
for MC4R gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MC4R gene, integrated from 9 sources (see all 492):
(articles sorted by number of sources associating them with MC4R) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children. (PubMed id 11487744)1, 2, 4, 9 Dubern B.... Tounian P. (2001)
- Prevalence of mutations and functional analyses of melanocortin 4 receptor variants identified among 750 men with juvenile-onset obesity. (PubMed id 15486053)1, 2, 4, 9 Larsen L.H....Pedersen O. (2005)
- Identification and characterization of melanocortin-4 receptor gene mutations in morbidly obese finnish children and adults. (PubMed id 14764818)1, 2, 4, 9 Valli-Jaakola K.... Schalin-Jaentti C. (2004)
- Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans. (PubMed id 10199800)1, 2, 4, 9 Hinney A.... Hebebrand J. (1999)
- [Prevalence of melanocortin 4 receptor (MC4R) mutations and polymorphismsin consecutively ascertained obese children and adolescents from a pediatric health care utilization population] (PubMed id 16032553)1, 4, 9 Zakel U.A....Hinney A. (2005)
- Six novel mutations in the proopiomelanocortin and melanocortin receptor 4 genes in severely obese adults living in southern Italy. (PubMed id 15951321)1, 4, 9 Buono P....Sacchetti L. (2005)
- The 103I variant of the melanocortin 4 receptor is associated with low serum triglyceride levels. (PubMed id 16278267)1, 4, 9 Bronner G....Schaefer J.R. (2006)
- A novel nonsense mutation in the melanocortin-4 receptor associated with obesity in a Spanish population. (PubMed id 12629567)1, 4, 9 Marti A....Hebebrand J. (2003)
- The human MC4R promoter: characterization and role in obesity. (PubMed id 14633862)1, 4, 9 Lubrano-Berthelier C....Vaisse C. (2003)
- Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity. (PubMed id 12959994)1, 4, 9 Tao Y.X. and Segaloff D.L. (2003)
|
External Searches for MC4R gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MC4R gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MC4R gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MC4R gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MC4R | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MC4R | | Wikipedia | http://en.wikipedia.org/wiki/Melanocortin_receptor |
|
| | |
About This Section
| Patent Information for MC4R gene:
Search GeneIP for patents involving MC4R
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MC4R gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for MC4R | | OriGene shRNA RFP for MC4R | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MC4R | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MC4R | | | OriGene Protein Over-expression Lysate for MC4R | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MC4R | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MC4R | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MC4R | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MC4R | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MC4R | | OriGene Custom Protein Services for MC4R | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MC4R | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MC4R | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MC4R | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MC4R | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MC4R | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MC4R |
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| | | | Tocris compounds for MC4R |
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 | | | MC4R Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MC4R |
|  |  |  | | | | ThermoFisher Antibodies for MC4R |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MC4R |
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