External Ids for MC4R Gene
Previous GeneCards Identifiers for MC4R Gene
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010]
GeneCards Summary for MC4R Gene
MC4R (Melanocortin 4 Receptor) is a Protein Coding gene. Diseases associated with MC4R include obesity, mc4r-related and obesity due to melanocortin 4 receptor deficiency. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include ubiquitin protein ligase binding and neuropeptide binding. An important paralog of this gene is LPAR1.
UniProtKB/Swiss-Prot for MC4R Gene
Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).
Melanocortin receptors are activated by members of the melanocortin family: alpha-, beta- and gamma-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). Endogenous antagonists include agouti and agouti-related protein (AgRP). The melanocortin receptors are G-protein-coupled and 5 subtypes exist, MC1-5. The melanocortins are involved in a wide range of physiological functions, including pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis and temperature control.