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MC2R Gene

protein-coding GIFtS: 65

GC18M013874

melanocortin 2 receptor (adrenocorticotropic hormone)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ACTH-R ^³
ACTHR ^¹, ², ³
MC2-R ^³
MGC125798 ^²
OTTHUMP00000162512 ^²

Descriptions
ACTH receptor ^², ³
Adrenocorticotropin receptor ^³
MC2 receptor ^²
Melanocortin receptor 2 ^³
corticotropin receptor ^²
melanocortin 2 receptor ^²
melanocortin 2 receptor (adrenocorticotropic hormone) ^²

External Ids
HGNC: 6930¹
Entrez Gene: 4158²
UniProtKB: Q01718³
Ensembl: ENSG00000185231⁷

Search outside databases for aliases for MC2R gene

Previous GC identifer: GC18M013963

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MC2R:

MC2R encodes one member of the five-member G-protein associated melanocortin receptor family.

Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides

derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic

hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin

ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. [provided by RefSeq]

UniProtKB/Swiss-Prot: ACTHR_HUMAN, Q01718

Function: Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate

adenylate cyclase

Gene Wiki entry for MC2R (ACTH_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MC2R gene

Entrez Gene cytogenetic band: 18p11.2 Ensembl cytogenetic band: 18p11.21 HGNC cytogenetic band: 18p11.2

MC2R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M013874: (about GC identifiers)

Start:	13,872,043 bp from pter
End:	13,905,535 bp from pter
Size:	33,493 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000018.8 NT_010859.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ACTHR_HUMAN, Q01718 (See protein sequence)

Recommended Name: Adrenocorticotropic hormone receptor

Size: 297 amino acids; 33927 Da

Subunit: Interacts with FALP/MRAP

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q3MI45 Q504X6

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000520.1

ENSEMBL proteins:

ENSP00000382718 ENSP00000333821

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant MC2R Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MC2 Receptor, MC2 receptor)
	Human Recombinant Proteins from Abnova (MC2R)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	9175632

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Antibodies for MC2R:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of MC2R
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (MC2 Receptor, MC2 receptor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MC2R)
	Novus Biologicals Antibody for MC2R

Assays for MC2R:

	Invitrogen Assays for MC2R
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q01718

ProtoNet protein and cluster: Q01718

2 Blocks protein families:

IPB001168 Adrenocorticotrophin receptor signature

IPB001671 Melanocortin receptor family signature

UniProtKB/Swiss-Prot: ACTHR_HUMAN, Q01718

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MC2R)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MC2R)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000529

Applied Biosystems Silencer® siRNAs for MC2R

Sigma-Aldrich siRNA and siRNA Panels for MC2R

Sigma-Aldrich shRNA Panels and shRNA for MC2R

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MC2R
		Millipore Clones for the Expression of MC2R

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000529
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000529
untagged cDNA clone in CMV expression vector: NM_000529

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000529

UniProtKB/Swiss-Prot: ACTHR_HUMAN, Q01718

Function: Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate

adenylate cyclase

Genatlas biochemistry entry for MC2R:

melanocortin receptor 2,expressed in melanocytes adrenal cortex,G protein coupled receptor

superfamily,with a loss of heterozygosity (LOH) in adrenocortical carcinoma

8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mc2r):

	adipose tissue	behavior/neurological	endocrine/exocrine gland	hematopoietic system
homeostasis/metabolism	immune system	lethality-postnatal

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004978	adrenocorticotropin receptor activity	TAS	9175632

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for MC2R

5/16 Interacting proteins for MC2R (ENSP00000333821³) via UniProtKB, MINT, and/or STRING (see all 16 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
POMC	ENSP00000370171³	STRING (score=.999)
MRAP	ENSP00000306697³	STRING (score=.972)
NR5A1	ENSP00000362690³	STRING (score=.967)
CRH	ENSP00000276571³	STRING (score=.933)
CYP17A1	ENSP00000358903³	STRING (score=.911)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	TAS	9175632

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for MC2R available from Tocris Bioscience

Compound	Action	CAS number
ACTH (1-39)	Potent endogenous MC2 agonist	[12279-41-3]
alpha-MSH	Endogenous melanocortin receptor agonist	[581-05-5]
Melanotan II	High affinity melanocortin receptor agonist	[121062-08-6]
[Nle4,D-Phe7]-alpha-MSH	Melanocortin receptor agonist	[75921-69-6]

About this table

10/16 Novoseek chemical compound relationships for MC2R gene (see all 16 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
acth	93.16	572	8550775 (13), 11420487 (7), 14671214 (7), 9167964 (7) (see all 99)
cpas	64.39	4	9582497 (2)
3beta-hydroxysteroid	57.83	4	11241179 (1), 7895901 (1)
steroid	51.34	7	10720064 (2), 15919738 (1), 18493136 (1), 9795339 (1)
forskolin	49.84	12	8961279 (4), 8550775 (2), 17712720 (1), 9141522 (1) (see all 5)
ribonucleic acid	43.43	6	9284742 (1), 15004405 (1), 9141522 (1), 10720064 (1)
dhea	40.66	3	16260430 (2)
androstenedione	35.10	1	9196605 (1)
dehydroepiandrosterone sulfate	34.28	4	9196605 (1), 7895901 (1)
cyclic amp	27.69	8	16402925 (1), 17082810 (1), 1655650 (1), 12530627 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MC2R)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MC2R)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000529

Sigma-Aldrich siRNA and siRNA Panels for MC2R

Sigma-Aldrich shRNA Panels and shRNA for MC2R

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000529

REFSEQ mRNAs for MC2R gene:

NM_000529.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000529

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000529
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000529
                                 untagged cDNA clone in CMV expression vector: NM_000529

Additional cDNA sequence:

AK289381.1 AK315319.1 BC069074.1 BC094710.1 BC104169.1 BC104170.1 Y10259.1

1 DOTS entry:

DT.91668476

4 AceView cDNA sequences:

BC069074 NM_000529 CF147776 Y10259

highest scoring ESTs for MC2R:

BC069074 BI830442 BX282244 CB985786 CF147776 NM_000529 BC094710 BP196054 DA014877 DA014945

Unigene Cluster for MC2R:

Melanocortin 2 receptor (adrenocorticotropic hormone)

Hs.248144 [show with all ESTs]

Unigene Representative Sequence: NM_000529

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000399821 ENST00000327606

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MC2R expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MC2R

¹ / ² / ³

5 probe-sets matching MC2R gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
420_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X65633	0.20	1.00	0.72	1
208568_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000529	0.60	1.00	0.82	1
217434_at²^{, 3}	U133-A	1	1.00	1.00	--	--	Y10259	0.40	1.00	0.76	1
208568_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217434_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGACTGTTGT

SOURCE GeneReport for Unigene cluster: Hs.248144
Expression variation in blood from EXPOLDB for MC2R
UniProtKB/Swiss-Prot: ACTHR_HUMAN, Q01718
Tissue specificity: Melanocytes and corticoadrenal tissue

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MC2R gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MC2R¹	--	melanocortin 2 receptor (adrenocorticotropic hormone)	87.23(n) 90.85(a)	483980 XM_541098.2 XP_541098.2
chimpanzee (Pan troglodytes)	MC2R¹	--	melanocortin 2 receptor (adrenocorticotropic hormone)	99.21(n) 99.33(a)	455500 XM_512192.2 XP_512192.1
cow (Bos taurus)	MC2R¹	--	melanocortin 2 receptor (adrenocorticotropic hormone)	85.36(n) 81.42(a)	281299 NM_174109.2 NP_776534.1
rat (Rattus norvegicus)	Mc2r¹	--	melanocortin 2 receptor	85.59(n) 90.2(a)	282839 XM_574167.2 XP_574167.1
mouse (Mus musculus)	Mc2r^{1, 5}	18 (37.00 cM)⁵	melanocortin 2 receptor^{1, 5}	84.46(n)¹ 88.85(a)¹	17200¹ NM_008560.2¹ NP_032586.1¹ AA474908⁵ AK033100⁵ (see all 15)

About this table Species with no ortholog for MC2R

ENSEMBL Gene Tree for MC2R

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MC2R gene

MC4R² MC3R² MC5R²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/328 NCBI SNPs in MC2R are shown (see all 328 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 167)

AB	SNP ID	Valid	Chr 18 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1940907^1,2	A,C,F,H,O	13872230(+)	`CTGAAC/GCTTGT`	1	--	ut3¹ ese³		17	EA NA MN EU WA	2816
	rs1893219^1,2	A,C,F,H	13906387(-)	`TCAGGT/CCTCTC`	1	--	ng3¹ trp³		4	EU EA WA	400
	rs4464147^1,2	A,C,F,H	13874009(+)	`AGGTGG/ACATCA`	1	--	ut3¹		9	EU EA WA NA CSAM	792
	rs12454469^1,2	A,C,F,H	13907057(+)	`AGACAT/CGCGGT`	1	--	ng3¹		11	NA EU EA WA	980
	rs2186944^1,2	A,C,F,H	13905542(+)	`AGCTCG/AGAGAG`	1	--	ng3¹ trp³		4	EU EA WA	378
	rs11878067^1,2	A,C,F,H	13906793(+)	`CAGACA/GATGGG`	1	--	ng3¹		7	NA EU EA WA	544
	rs4797825^1,2	A,C,F,H	13874566(+)	`TTACAT/CTATTC`	1	--	ut3¹ ese³		14	NA EU CSAM EA NS WA	1824
	rs1940906^1,2	C,F,H,O	13872198(+)	`TGATAA/GAAGAA`	1	--	ut3¹		13	NS MN NA EU EA WA	806
	rs1893220^1,2	A,C,F,H	13906294(-)	`TTGGCC/ACCAGC`	1	--	ng3¹		5	MN EU EA WA	598
	rs4797824^1,2	A,C,F,H	13874513(+)	`TGCATA/C/TCATTA`	1	--	ut3¹ ese³		22	NA EU CSAM EA NS WA	2344

About this table

HapMap Linkage Disequilibrium images for MC2R (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607397 disorders: 202200

UniProtKB/Swiss-Prot: ACTHR_HUMAN, Q01718

Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1) [MIM:202200];

also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive

disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is

characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency

10/19 Novoseek disease relationships for MC2R gene (see all 19 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
acth resistance	96.23	15	18426811 (2), 17161331 (1), 18407210 (1), 17128564 (1) (see all 10)
allgrove syndrome	87.22	6	18426811 (1), 1850671 (1), 18407210 (1), 11701718 (1)
adrenocortical cancer	80.14	3	7883845 (1)
carcinoma adrenocortical	78.56	7	15879363 (1), 9582497 (1), 8187950 (1), 9795339 (1) (see all 5)
adrenal tumor	74.63	9	9167964 (2), 9284742 (1), 12727943 (1), 11248736 (1) (see all 6)
adenoma adrenocortical	72.10	4	11420487 (1), 10216530 (1), 11004727 (1)
cushing syndrome	71.49	6	11420487 (2), 12456795 (1)
adrenal adenoma	70.89	1	15879363 (1)
adrenal disease	60.05	2	9167964 (2)
adenoma	59.64	25	11420487 (7), 9582497 (2), 9888585 (2), 14671214 (2) (see all 11)

About this table

Genatlas disease: MC2R

Addison disease with ACTH resistant adrenal insufficiency and glucocorticoid

deficiency,characterized by failure to thrive,weakness and fatigue or adrenal crisis

Human Gene Mutation Database: MC2R
Genetic Association Database: MC2R
Human Genome Epidemiology Navigator: MC2R (9 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/206 PubMed articles for MC2R gene (see all 206 ):

Hereditary isolated glucocorticoid deficiency is associated with abnormalities of the adrenocorticotropin receptor gene. (PubMed id 8227361)^{3, 4, 6} Tsigos C.... Chrousos G.P. (1993)
Clinical, genetic, and functional characterization of adrenocorticotropin receptor mutations using a novel receptor assay. (PubMed id 12213892)^{1, 3, 4} Fluck C.E.... Miller W.L. (2002)
Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2. (PubMed id 15654338)^{1, 3, 4} Metherell L.A....Clark A.J. (2005)
Characterization of an adrenocorticotropin (ACTH) receptor promoter polymorphism leading to decreased adrenal responsiveness to ACTH. (PubMed id 15240582)^{1, 3, 6} Slawik M....Beuschlein F. (2004)
Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor. (PubMed id 8094489)^{1, 3, 4} Clark A.J.L.... Grossman A. (1993)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Novel mutations of the ACTH receptor gene in a female adult patient with adrenal unresponsiveness to ACTH. (PubMed id 10971458)^{3, 4} Ishii T.... Matsuo N. (2000)
Demonstration by transfection studies that mutations in the adrenocorticotropin receptor gene are one cause of the hereditary syndrome of glucocorticoid deficiency. (PubMed id 8636348)^{3, 4} Naville D.... Begeot M. (1996)
Molecular cloning of a novel melanocortin receptor. (PubMed id 8463333)^{3, 4} Gantz I.... Yamada T. (1993)
Cloning and functional characterization of a family of receptors for the melanotropic peptides. (PubMed id 8390157)^{2, 3} Cone R.D....Mortrud M.T. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4158	HGNC: 6930	AceView: MC2R	Ensembl:ENSG00000185231	euGenes: HUgn4158
ECgene: MC2R	H-InvDB: MC2R

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=MC2R

Licensable Technologies for MC2R
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MC2R:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MC2R-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MC2R		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MC2R		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MC2R)
	Antibodies (MC2R)
	Chimera RNAi (MC2R)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (MC2 Receptor, MC2 receptor)
	Antibodies (MC2 Receptor, MC2 receptor)

Search OriGene for MC2R

Tocris compounds for MC2R

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MC2R

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MC2R Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for MC2R

Summaries
for MC2R

Genomic Location
for MC2R

Proteins
for MC2R

Protein Domains/
Families
for MC2R

Gene Function
for MC2R

Pathways & Interactions
for MC2R

Drugs & Compounds
for MC2R

Transcripts
for MC2R

Expression
for MC2R

Orthologs
for MC2R

Paralogs
for MC2R

SNPs/Variants
for MC2R

Disorders & Mutations
for MC2R

Medical News
for MC2R

Publications
for MC2R

Search for MC2R

Genome Databases showing MC2R

Other Databases showing MC2R

Specialized Databases showing MC2R

Licensable Technologies
for MC2R

Services
for MC2R

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MC2R Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor MC2R

Summariesfor MC2R

Genomic Locationfor MC2R

Proteinsfor MC2R

Protein Domains/Familiesfor MC2R

Gene Functionfor MC2R

Pathways & Interactionsfor MC2R

Drugs & Compoundsfor MC2R

Transcriptsfor MC2R

Expression for MC2R

Orthologsfor MC2R

Paralogsfor MC2R

SNPs/Variantsfor MC2R

Disorders & Mutationsfor MC2R

Medical Newsfor MC2R

Publicationsfor MC2R

Search for MC2R

Genome Databases showing MC2R

Other Databases showing MC2R

Specialized Databases showing MC2R

Licensable Technologiesfor MC2R

Servicesfor MC2R

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MC2R

Summaries
for MC2R

Genomic Location
for MC2R

Proteins
for MC2R

Protein Domains/
Families
for MC2R

Gene Function
for MC2R

Pathways & Interactions
for MC2R

Drugs & Compounds
for MC2R

Transcripts
for MC2R

Expression
for MC2R

Orthologs
for MC2R

Paralogs
for MC2R

SNPs/Variants
for MC2R

Disorders & Mutations
for MC2R

Medical News
for MC2R

Publications
for MC2R

Licensable Technologies
for MC2R

Services
for MC2R