MC1R Gene
protein-coding GIFtS: 62
GCID: GC16P089982
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|
melanocortin 1 receptor (alpha melanocyte stimulating hormone...
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Aliases
for MC1R gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Melanocortin 1 Receptor (Alpha Melanocyte Stimulating Hormone Receptor)1 2 | | Melanocyte-Stimulating Hormone Receptor2 | | MSH-R1 2 3 | | Melanotropin Receptor2 | | MC1-R2 3 | | MSHR3 | | CMM52 5 | | Melanocortin Receptor 13 | | SHEP22 5 | | |
Export aliases for MC1R gene to outside databasesPrevious GC identifers: GC16P081304 GC16P090971 GC16P089685 GC16P089727 GC16P088513 GC16P089985 |
Summaries
for MC1R gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MC1R:
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, aseven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: redpheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increasedpheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin maycontribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptoractivates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sunsensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have beenidentified which correlate with skin and hair color, providing evidence that this gene is an important component indetermining normal human pigment variation. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MSHR_HUMAN, Q01726Function: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteinswhich activate adenylate cyclase
 summary
for MC1R: Melanocortin receptors are activated by members of the melanocortin family: alpha-, beta- and
gamma-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). Endogenous antagonists
include agouti and agouti-related protein (AgRP). The melanocortin receptors are G-protein-coupled and 5
subtypes exist, MC1-5. The melanocortins are involved in a wide range of physiological functions, including
pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis and temperature control.
Gene Wiki entry for MC1R (Melanocortin 1 receptor)
|
Genomic Views
for MC1R gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010542.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MC1R gene promoter:
HOXA9B HOXA9 CREB NRSF form 1 MyoD ZIC2/Zic2 NRSF form 2 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MC1R
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MC1R |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q24.3 Ensembl cytogenetic band: 16q24.3 HGNC cytogenetic band: 16q24.3MC1R Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P089982: view genomic region
(about GC identifiers)
Start:
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89,978,527 bp from pter |
End:
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89,987,385 bp from pter |
Size:
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8,859 bases |
Orientation:
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plus strand |
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Proteins
for MC1R gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MSHR_HUMAN, Q01726 (See
protein sequence)Recommended Name: Melanocyte-stimulating hormone receptor Size: 317 amino acids; 34706 Da
Subunit: Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes withGNAS-binding and thus inhibits agonist-induced cAMP production
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q66K38 Q8WWX6 Q8WWX7 Q96I33 Q96RU4 Q9UBF7 Q9UN58 Q9UN59 Q9UN60 Q9UN61 Q9UN62Explore the universe of human proteins at neXtProt for MC1R: NX_Q01726
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q01726
MC1R Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002377.4
ENSEMBL proteins: ENSP00000451760 ENSP00000451605 Reactome Protein details: Q01726
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
MC1R for ontologies About GeneDecksing
MC1R Antibody Products:
Assay Products for MC1R: |
Protein
Domains /
Families
for MC1R gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MC1R for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q01726ProtoNet protein and cluster: Q01726 2 Blocks protein families: IPB000761 Melanocyte stimulating hormone receptor signature IPB001671 Melanocortin receptor family signature
UniProtKB/Swiss-Prot: MSHR_HUMAN, Q01726Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for MC1R gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MSHR_HUMAN, Q01726Function: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteinswhich activate adenylate cyclase Genatlas biochemistry entry for MC1R:melanocortin receptor 1,murine extension (Ext) homolog,expressed in cells of melanocytic origin and adrenal cortex,Gprotein coupled receptor superfamily,regulator of eumelanin and phaeomelanin production
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MC1R (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MC1R
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MC1R (NM_002386) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MC1R | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MC1R |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MC1R |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
MC1R for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MC1R:
Animal Models:
10 MGI mutant phenotypes (inferred from 9 alleles ) (MGI details for Mc1r):
MC1R for phenotypes About GeneDecksing
|
Pathways & Interactions
for MC1R gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | Adenylate cyclase-activating neuropeptides | | | 4 | Melanocyte Development and Pigmentation | | | 5 | Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for MC1R
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MC1R
2  BioSystems Pathways for MC1R
5/7 
Reactome Pathways for MC1R (see all 7)
2 
Kegg Pathways (Kegg details for MC1R):
MC1R for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MC1R
4 Interacting proteins for MC1R (Q017263) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table
MC1R for ontologies About GeneDecksing
|
Drugs & Compounds
for MC1R gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MC1R for compounds About GeneDecksing
Compounds for MC1R available from Tocris Bioscience About this table
10/23 Novoseek chemical compound relationships for MC1R gene (see all 23) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| eumelanin |
92 |
57 |
16524431 (2), 12006619 (2), 16827749 (2), 12503631 (2) (see all 30) |
| phaeomelanin |
88.5 |
15 |
10403794 (1), 7581459 (1), 10101176 (1), 11837451 (1) (see all 8) |
| alpha msh |
84.4 |
28 |
16177130 (4), 12439754 (3), 12473109 (3), 11689486 (2) (see all 6) |
| acth |
68.7 |
45 |
11041375 (3), 10029451 (2), 15498881 (2), 15748644 (2) (see all 22) |
| dopachrome |
64.9 |
3 |
9862732 (1), 11493672 (1), 12519127 (1) |
| shu 9119 |
64.1 |
1 |
17127674 (1) |
| tripeptide |
44.3 |
1 |
19558415 (1) |
| tripeptide s |
38 |
1 |
15102092 (1) |
| vitamin d |
21.9 |
9 |
15210908 (1), 17523926 (1), 15609895 (1), 11720436 (1) (see all 6) |
| cyclic amp |
18.9 |
11 |
15102092 (2), 16274845 (2), 9571181 (1), 12503631 (1) |
Search CenterWatch for drugs/clinical trials and news about MC1R / MSHR
|
Transcripts
for MC1R gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MC1R gene: NM_002386.3 Unigene Cluster for MC1R: Melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) Hs.513829 [show with all ESTs]Unigene Representative Sequence: NM_0023863 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000539976(uc010ciy.1) ENST00000555427 ENST00000555147(uc002fpe.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MC1R (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MC1R
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MC1R (NM_002386) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MC1R | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MC1R |
Additional cDNA sequence: AK024232.1 AK054666.1 AK225902.1 BC007856.2 BC080622.1 X67594.1 6 DOTS entries: DT.406626 DT.120721036 DT.100735529 DT.121643636 DT.97778643 DT.120720907 24/933 AceView cDNA sequences (see all 933): CR613956 BX441201 CR608519 BC020171 BI870630 CR623379 BX460810 BE254057 CR594464 BQ944928 CR594636 CR616005 BQ679424 BU527312 CR593464 CA413850 CB121519 BQ420332 CR610920 CR611692 CB152242 CA421315 CR614385 BU529036
GeneLoc Exon Structure
|
Expression
for MC1R gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MC1R expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGCCAGGAA
About this image
See MC1R Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MC1R
SOURCE GeneReport for Unigene cluster: Hs.513829
UniProtKB/Swiss-Prot: MSHR_HUMAN, Q01726Tissue specificity: Melanocytes and corticoadrenal tissue
SABiosciences Expression via Pathway-Focused PCR Array including MC1R: | G Protein Coupled Receptors 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MC1R
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MC1R | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MC1R | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MC1R | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MC1R |
Orthologs
for MC1R gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MC1R gene from 2/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MC1R1 |
melanocortin 1 receptor (alpha melanocyte stimulating more |
74.04(n)
62.24(a) |
|
427562 NM_001031462.1 NP_001026633.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
mc1r1 |
melanocortin 1 receptor |
63.46(n)
60.82(a) |
|
353151 NM_180970.1 NP_851301.1 |
ENSEMBL Gene Tree for MC1R (if available)
TreeFam Gene Tree for MC1R (if available) |
Paralogs
for MC1R gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MC1R gene
- CNR12 GPR122 ENSG000002675342 LPAR22 CNR22 S1PR12 S1PR32 LPAR12
- MC3R2 MC5R2 MC2R2 GPR32 MC4R2 S1PR42 GPR62 LPAR32
- S1PR52
5 SIMAP similar genes for MC1R using alignment to 21 protein entries: MSHR_HUMAN (see all proteins):MC4R MC3R MC5R LOC441453 MC2R
MC1R for paralogs About GeneDecksing
|
Genomic Variants
for MC1R gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: MSHR_HUMAN, Q01726Polymorphism: Genetic variants in MC1R define the skin/hair/eye pigmentation variation locus 2 (SHEP2) [MIM:266300].Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normalrange that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighterpigmentation with increasing distance from the equator, with type I skin being the most lightly pigmented and type IVthe most dark pigmented. By contrast, the majority of variation in human eye and hair color is found among individualsof European ancestry, with most other human populations fixed for brown eyes and black hair. Partial loss-of-functionmutations are associated with fair skin, poor tanning and increased skin cancer riskPolymorphism: MC1R variants associated with red hair and fair skin, determine female-specific increased analgesia fromkappa-opioid receptor agonist [MIM:613098]
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MC1R (89978527 - 89987385 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MC1R: --
Human Gene Mutation Database (HGMD): MC1R
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MC1R gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MC1R for disorders About GeneDecksing
OMIM gene information: 155555
OMIM disorders: 266300 613099 613098 203200
UniProtKB/Swiss-Prot: MSHR_HUMAN, Q01726
Genetic variations in MC1R are a cause of susceptibility to cutaneous malignant melanoma type 5 (CMM5)[MIM:613099]. Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-existing benignnevus, which occurs most often in the skin but also may involve other sites
20/47  diseases for MC1R (see all 47): About MalaCardsanalgesia from kappa-opioid receptor agonist, female-specific skin/hair/eye pigmentation 2, blond hair/fair skin skin/hair/eye pigmentation 2, red hair/fair skin uv-induced skin damage
oculocutaneous albinism, type ii, modifier of,0 type vi ehlers-danlos syndrome melanoma skin cancer
oculocutaneous albinism xeroderma pigmentosum, group c oculocutaneous albinism type 2 ehlers-danlos syndrome
vulvar vestibulitis syndrome nevoid basal cell carcinoma syndrome xeroderma pigmentosum acanthosis nigricans
albinism dengue hemorrhagic fever back pain hemorrhagic fever
3 diseases from the University of Copenhagen DISEASES database for MC1R:Melanoma Skin cancer Oculocutaneous albinism 10/30 Novoseek disease relationships for MC1R gene (see all 30) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| melanoma |
82 |
386 |
12177778 (7), 15998953 (7), 12439754 (7), 16172233 (7) (see all 99) |
| skin cancer |
80.1 |
67 |
16721784 (4), 12753400 (3), 17130136 (3), 12006619 (2) (see all 39) |
| freckles |
75.6 |
15 |
11487574 (5), 18079748 (1), 15250941 (1), 17371441 (1) (see all 5) |
| melanoma cloudman s91 |
63.7 |
2 |
10614575 (1) |
| albinism oculocutaneous |
63.5 |
7 |
11499678 (1), 19710684 (1), 18392143 (1), 17570052 (1) |
| nevi |
63 |
9 |
10536983 (1), 16214921 (1), 15998953 (1), 14709592 (1) (see all 8) |
| nonmelanoma skin cancer |
60.3 |
7 |
11254446 (3), 16982779 (1), 11830546 (1), 11708951 (1) |
| dysplastic nevi |
57.3 |
4 |
16214921 (2), 19484507 (1), 16172233 (1) |
| carcinoma basal cell |
52.7 |
18 |
11179997 (3), 10340440 (2), 16645598 (2), 18067130 (2) (see all 8) |
| albinism |
46.8 |
1 |
14616056 (1) |
Genetic Association Database (GAD): MC1R
Human Genome Epidemiology (HuGE) Navigator: MC1R (100 documents)
Export disorders for MC1R gene to outside databases
|
Publications
for MC1R gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MC1R gene, integrated from 9 sources (see all 464):
(articles sorted by number of sources associating them with MC1R) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- High polymorphism at the human melanocortin 1 receptor locus. (PubMed id 10101176)1, 2, 9 Rana B.K....Li W.H. (1999)
- Identification of novel functional variants of the melanocortin 1 receptor gene originated from Asians. (PubMed id 16463023)1, 2, 9 Nakayama K.... Ishida T. (2006)
- The melanocortin-1-receptor gene is the major freckle gene. (PubMed id 11487574)1, 4, 9 Bastiaens M....Bouwes Bavinck J.N. (2001)
- Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells define structural determinants of receptor function. (PubMed id 12473109)1, 2, 9 Sanchez Mas J.... Jimenez-Cervantes C. (2002)
- Melanocortin-1 receptor genotype is a risk factor for basal and squamous cell carcinoma. (PubMed id 11179997)1, 4, 9 Box N.F....Sturm R.A. (2001)
- The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma. (PubMed id 8894704)1, 2, 9 Valverde P.... Rees J.L. (1996)
- Identification and functional analysis of novel variants of the human melanocortin 1 receptor found in melanoma patients. (PubMed id 19338054)1, 2, 9 Perez Oliva A.B.... Ribas G. (2009)
- Novel MC1R variants in Ligurian melanoma patients and controls. (PubMed id 15221796)1, 4, 9 Pastorino L....Scarra G.B. (2004)
- MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations. (PubMed id 11500805)1, 4, 9 Box N.F....Hayward N.K. (2001)
- Melanocortin 1 receptor variants in an Irish population. (PubMed id 9665397)1, 2, 9 Smith R.... Rees J.L. (1998)
|
External Searches for MC1R gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MC1R gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing MC1R gene
(According to HUGE)
About This Section
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Specialized Databases showing MC1R gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for MC1R gene:
Search GeneIP for patents involving MC1R
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MC1R gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for MC1R | | OriGene shRNA RFP for MC1R | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MC1R | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MC1R | | | OriGene Protein Over-expression Lysate for MC1R | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MC1R | | OriGene 3'-UTR Clone for MC1R | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MC1R | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MC1R | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MC1R | | OriGene Custom Protein Services for MC1R | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MC1R | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MC1R | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MC1R | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MC1R | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MC1R | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MC1R |
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| | | | Tocris compounds for MC1R |
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 | | | MC1R Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MC1R |
|  |  |  | | | | ThermoFisher Antibodies for MC1R |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MC1R |
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