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MC1R Gene

protein-coding GIFtS: 68

GC16P088513

melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MC1-R ^³
MGC14337 ^²
MSH-R ^¹, ², ³
MSHR ^³
SHEP2 ^², ⁵

Descriptions
Melanocortin receptor 1 ^³
Melanotropin receptor ^², ³
melanocortin 1 receptor ^²
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) ^²

External Ids
HGNC: 6929¹
Entrez Gene: 4157²
UniProtKB: Q01726³
Ensembl: ENSG00000198211⁷

Search outside databases for aliases for MC1R gene

Previous GC identifers: GC16P081304 GC16P090971 GC16P089685 GC16P089727

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MC1R:

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The

encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis.

Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a

loss in function are associated with increased pheomelanin production, which leads to lighter skin

and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin

damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the

receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun

sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30

variant alleles have been identified which correlate with skin and hair color, providing evidence

that this gene is an important component in determining normal human pigment variation. [provided

by RefSeq]

UniProtKB/Swiss-Prot: MSHR_HUMAN, Q01726

Function: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is

mediated by G proteins which activate adenylate cyclase

Gene Wiki entry for MC1R (Melanocortin_1_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MC1R gene

Entrez Gene cytogenetic band: 16q24.3 Ensembl cytogenetic band: 16q24.3 HGNC cytogenetic band: 16q24.3

MC1R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P088513: (about GC identifiers)

Start:	88,512,527 bp from pter
End:	88,530,006 bp from pter
Size:	17,480 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000016.8 NT_010542.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MSHR_HUMAN, Q01726 (See protein sequence)

Recommended Name: Melanocyte-stimulating hormone receptor

Size: 317 amino acids; 34706 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q66K38 Q8WWX6 Q8WWX7 Q96I33 Q96RU4 Q9UBF7 Q9UN58 Q9UN59 Q9UN60 Q9UN61 Q9UN62

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002377.4

ENSEMBL proteins:

ENSP00000302777 ENSP00000320295

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant MC1R Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MC1 Receptor)
	Human Recombinant Proteins from Abnova (MC1R)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	9571181

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Antibodies for MC1R:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of MC1R
	Sigma-Aldrich Antibodies for MC1R
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (MC1 Receptor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MC1R)
	Novus Biologicals Antibody for MC1R

Assays for MC1R:

	Invitrogen Assays for MC1R
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q01726

ProtoNet protein and cluster: Q01726

2 Blocks protein families:

IPB000761 Melanocyte stimulating hormone receptor signature

IPB001671 Melanocortin receptor family signature

UniProtKB/Swiss-Prot: MSHR_HUMAN, Q01726

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MC1R)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MC1R)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002386

Applied Biosystems Silencer® siRNAs for MC1R

Sigma-Aldrich siRNA and siRNA Panels for MC1R

Sigma-Aldrich shRNA Panels and shRNA for MC1R

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MC1R
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002386
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002386
untagged cDNA clone in CMV expression vector: NM_002386

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002386

UniProtKB/Swiss-Prot: MSHR_HUMAN, Q01726

Function: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is

mediated by G proteins which activate adenylate cyclase

Genatlas biochemistry entry for MC1R:

melanocortin receptor 1,murine extension (Ext) homolog,expressed in cells of melanocytic origin and

adrenal cortex,G protein coupled receptor superfamily,regulator of eumelanin and phaeomelanin

production

10 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Mc1r):

behavior/neurological	cellular	craniofacial	growth/size	hearing/vestibular/ear
limbs/digits/tail	pigmentation	skin/coat/nails	touch/vibrissae	tumorigenesis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004980	melanocyte stimulating hormone receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for MC1R (Your Favorite Gene powered by Ingenuity)

Melanocyte Development and Pigmentation Signaling

GeneDecks MC1R for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for MC1R

5/58 Interacting proteins for MC1R (ENSP00000302777³) via UniProtKB, MINT, and/or STRING (see all 58 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
POMC	ENSP00000370171³	STRING (score=.999)
ASIP	ENSP00000364092³	STRING (score=.993)
PARD3	ENSP00000363921³	STRING (score=.965)
MC4R	ENSP00000299766³	STRING (score=.963)
TCP1	ENSP00000317334³	STRING (score=.953)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	TAS	9571181
GO:0007275	multicellular organismal development	TAS	7581459
GO:0009650	UV protection	TAS	7581459

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for MC1R available from Tocris Bioscience

Compound	Action	CAS number
Galanin (1-30) (human)	Endogenous galanin receptor agonist	[119418-04-1]
alpha-MSH	Endogenous melanocortin receptor agonist	[581-05-5]
Melanotan II	High affinity melanocortin receptor agonist	[121062-08-6]
[Nle4,D-Phe7]-alpha-MSH	Melanocortin receptor agonist	[75921-69-6]

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10/14 Novoseek chemical compound relationships for MC1R gene (see all 14 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
eumelanin	92.56	56	16524431 (2), 12006619 (2), 16827749 (2), 12503631 (2) (see all 29)
phaeomelanin	89.09	15	10403794 (1), 7581459 (1), 10101176 (1), 11837451 (1) (see all 8)
alpha msh	85.52	28	16177130 (4), 12439754 (3), 12473109 (3), 11689486 (2) (see all 6)
acth	68.51	44	11041375 (3), 10029451 (2), 15498881 (2), 15748644 (2) (see all 21)
dopachrome	66.62	3	9862732 (1), 11493672 (1), 12519127 (1)
shu 9119	59.65	1	17127674 (1)
cyclic amp	21.15	11	15102092 (2), 16274845 (2), 9571181 (1), 12503631 (1)
tripeptide s	19.91	1	15102092 (1)
calcium	5.07	4	9124542 (1), 16914090 (1)
dithiothreitol	3.96	1	11237737 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MC1R)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MC1R)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002386

Sigma-Aldrich siRNA and siRNA Panels for MC1R

Sigma-Aldrich shRNA Panels and shRNA for MC1R

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002386

REFSEQ mRNAs for MC1R gene:

NM_002386.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002386

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002386
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002386
                                 untagged cDNA clone in CMV expression vector: NM_002386

Additional cDNA sequence:

AK024232.1 AK054666.1 AK225902.1 AK311630.1 BC007856.2 BC080622.1 X67594.1

9 DOTS entries:

DT.406626 DT.120721036 DT.121643636 DT.100735529 DT.91667661 DT.97778643 DT.97795732 DT.120720907

DT.95166574

24/933 AceView cDNA sequences (see all 933 ):

CR596505 BX442565 BX464037 AU119449 BQ924056 CR625315 BC001678 BX460133

BE784462 BQ639410 CR590075 CR612113 CR605315 AL537104 CR624149 CR610945

BF568062 BC020171 BM557821 BQ925781 CR594431 CR601082 BQ676579 BU527312

highest scoring ESTs for MC1R:

AI123000 X67594 AA431397 AA432389 AA778295 AI379405 AI911373 AK024232 AU150244 AW270712

Unigene Cluster for MC1R:

Melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)

Hs.513829 [show with all ESTs]

Unigene Representative Sequence: AK311630

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for MC1R (see all 11 )

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b	^	10	^	11a	·	11b	·	11c	·	11d	·	11e
SP1:					-		-		-		-		-		-		-		-				-						-		-		-
SP2:							-		-		-		-		-		-		-				-						-		-		-
SP3:											-		-		-		-		-				-						-		-		-
SP4:													-		-		-		-				-						-		-		-
SP5:																	-		-				-						-		-		-

About this scheme

ECgene alternative splicing isoforms for MC1R

2 Ensembl transcripts including schematic representations:

ENST00000304984 ENST00000315491

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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MC1R expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MC1R

¹ / ² / ³

4 probe-sets matching MC1R gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34557_at²^{, 3}	U95-A	2	1.00	0.59	0.85	0.80	X67594	1.00	0.90	0.95	1
54532_at²^{, 3}	U95-C	2	0.94	0.83	0.94	1.21	AI123000	1.00	0.90	0.95	1
205458_at²^{, 3}	U133-A	2	1.00	0.82	--	--	BG034972	0.80	1.00	0.91	1
205458_at²	U133Plus2	2	1.00	0.82	--	--	--	--	--	--	--

GeneDecks MC1R for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGGCCAGGAA

SOURCE GeneReport for Unigene cluster: Hs.513829
Expression variation in blood from EXPOLDB for MC1R
UniProtKB/Swiss-Prot: MSHR_HUMAN, Q01726
Tissue specificity: Melanocytes and corticoadrenal tissue

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MC1R gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MC1R¹	--	melanocortin 1 receptor (alpha melanocyte stimulating more	83.7(n) 80.13(a)	489652 NM_001014282.1 NP_001014304.1
chimpanzee (Pan troglodytes)	MC1R¹	--	melanocortin 1 receptor (alpha melanocyte stimulating more	98.21(n) 97.15(a)	493980 NM_001009152.1 NP_001009152.1
cow (Bos taurus)	MC1R¹	--	melanocortin 1 receptor (alpha melanocyte stimulating more	84.65(n) 80.76(a)	281298 NM_174108.2 NP_776533.1
mouse (Mus musculus)	Mc1r^{1, 5}	8 (68.00 cM)⁵	melanocortin 1 receptor^{1, 5}	79.68(n)¹ 76.51(a)¹	17199¹ NM_008559.2¹ NP_032585.2¹ AB177607⁵ AB177608⁵ (see all 15)
chicken (Gallus gallus)	MC1R¹	--	melanocortin 1 receptor (alpha melanocyte stimulating more	74.04(n) 61.9(a)	427562 NM_001031462.1 NP_001026633.1

About this table Species with no ortholog for MC1R

ENSEMBL Gene Tree for MC1R

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MC1R gene

ENSG00000173213² ENSG00000159247² TUBB6² TUBB1² TUBB4Q² ENSG00000173876²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: MSHR_HUMAN, Q01726

Polymorphism: Variations in MC1R are linked to the degree of skin pigmentation (Types I-IV). Type I

skin the most lightly pigmented and type IV the most dark pigmented. Partial loss-of-function

mutations are associated with fair skin, poor tanning and increased skin cancer risk

Polymorphism: Genetic variations in MC1R are associated with variation in skin/hair/eye

pigmentation type 2 (SHEP2) [MIM:266300]. Hair, eye and skin pigmentation are among the most

visible examples of human phenotypic variation, with a broad normal range that is subject to

substantial geographic stratification. In the case of skin, individuals tend to have lighter

pigmentation with increasing distance from the equator. By contrast, the majority of variation in

human eye and hair color is found among individuals of European ancestry, with most other human

populations fixed for brown eyes and black hair

10/70 NCBI SNPs in MC1R are shown (see all 70 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 52)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3212357^1,2	A,C,F,H	88512105(+)	`CTCACC/TAGGGT`	1	--	ut5¹		5	NS EA WA	374
	rs885479^1,2	A,C,F,H	88513655(+)	`GCGGCG/AAGCCG`	1	Q/R	mis¹ ese³		13	MN EU EA WA NS CSAM NA	1178
	rs3212369^1,2	A,C,F,H	88514261(+)	`CTGAAA/GGTGTT`	1	--	ut3¹		10	NS EU EA WA	890
	rs3212363^1,2	C,F,H	88512942(+)	`GCGGTT/AGATGC`	1	--	ut5¹		16	NS EA NA EU WA	1960
	rs1805005^1,2	C,F,H	88513345(+)	`TGGTGG/TTGGCC`	1	V/L	mis¹		13	MN NS EU EA WA CSAM NA	1042
	rs3212368^1,2	C,F,H	88514133(+)	`TGCACG/ACGGCT`	1	--	ut3¹		9	NS EU EA WA NA	592
	rs3212366^1,2	C,F,H	88513753(+)	`TCTTCT/CTCCTG`	1	L/F	mis¹ ese³ trp³		11	NS EU EA WA MN CSAM	918
--	rs3212358^1,2	A,C,F	88512240(+)	`TCTACG/AAGATG`	1	--	ut5¹		8	NS	752
	rs1805007^1,2	C,F,H	88513618(+)	`CACTGC/G/TGCTAC`	2	R/G R/C	mis¹ ese³		19	NS NA EU EA WA MN CSAM	1526
--	rs3212354^1,2	A,C,F	88511871(+)	`CCCTCC/TCCACC`	1	--	ut5¹		2	NS	88

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HapMap Linkage Disequilibrium images for MC1R (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 155555

10/30 Novoseek disease relationships for MC1R gene (see all 30 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
melanoma	80.91	323	12177778 (7), 15998953 (7), 12439754 (7), 16172233 (7) (see all 99)
skin cancer	79.37	58	16721784 (4), 12753400 (3), 17130136 (3), 12006619 (2) (see all 33)
freckles	70.28	14	11487574 (5), 18079748 (1), 15250941 (1), 17371441 (1)
melanoma cloudman s91	64.99	2	10614575 (1)
nevi	61.01	7	10536983 (1), 16214921 (1), 15998953 (1), 14709592 (1) (see all 7)
nonmelanoma skin cancer	59.95	7	11254446 (3), 16982779 (1), 11830546 (1), 11708951 (1)
albinism oculocutaneous	57.84	5	11499678 (1), 18392143 (1), 17570052 (1)
dysplastic nevi	55.12	3	16214921 (2), 16172233 (1)
carcinoma basal cell	53.55	18	11179997 (3), 10340440 (2), 16645598 (2), 18067130 (2) (see all 8)
lentigines	45.52	5	11487574 (3), 18079748 (1), 17371441 (1)

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Human Gene Mutation Database: MC1R
Genetic Association Database: MC1R
Human Genome Epidemiology Navigator: MC1R (66 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/364 PubMed articles for MC1R gene (see all 364 ):

High polymorphism at the human melanocortin 1 receptor locus. (PubMed id 10101176)^{1, 3, 4} Rana B.K....Li W.H. (1999)
Identification of novel functional variants of the melanocortin 1 receptor gene originated from Asians. (PubMed id 16463023)^{1, 3, 4} Nakayama K.... Ishida T. (2006)
The melanocortin-1-receptor gene is the major freckle gene. (PubMed id 11487574)^{1, 3, 6} Bastiaens M....Bouwes Bavinck J.N. (2001)
Melanocortin-1 receptor genotype is a risk factor for basal and squamous cell carcinoma. (PubMed id 11179997)^{1, 3, 6} Box N.F....Sturm R.A. (2001)
The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma. (PubMed id 8894704)^{1, 3, 4} Valverde P.... Rees J.L. (1996)
Novel MC1R variants in Ligurian melanoma patients and controls. (PubMed id 15221796)^{1, 3, 6} Pastorino L....Scarra G.B. (2004)
MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations. (PubMed id 11500805)^{1, 3, 6} Box N.F....Hayward N.K. (2001)
Melanocortin 1 receptor variants in an Irish population. (PubMed id 9665397)^{1, 3, 4} Smith R.... Rees J.L. (1998)
Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair. (PubMed id 9302268)^{1, 3, 4} Box N.F.... Sturm R.A. (1997)
Polymorphisms in the melanocortin-1 receptor (MC1R) and agouti signaling protein (ASIP) genes in Korean vitiligo patients. (PubMed id 12859622)^{1, 3, 6} Na G.Y....Kim J.C. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4157	HGNC: 6929	AceView: MC1RandTUBB4	Ensembl:ENSG00000198211	euGenes: HUgn4157
ECgene: MC1R	H-InvDB: MC1R

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for MC1R	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/mc1r/

Licensable Technologies for MC1R
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MC1R:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MC1R-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MC1R		Antibodies for MC1R
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MC1R		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MC1R)
	Antibodies (MC1R)
	Chimera RNAi (MC1R)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (MC1 Receptor)
	Antibodies (MC1 Receptor)

Search OriGene for MC1R

Tocris compounds for MC1R

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MC1R

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
MC1R Gene at Home site.
Version 2.41.1
server5.xennexinc.com

MC1R Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for MC1R

Summaries
for MC1R

Genomic Location
for MC1R

Proteins
for MC1R

Protein Domains/
Families
for MC1R

Gene Function
for MC1R

Pathways & Interactions
for MC1R

Drugs & Compounds
for MC1R

Transcripts
for MC1R

Expression
for MC1R

Orthologs
for MC1R

Paralogs
for MC1R

SNPs/Variants
for MC1R

Disorders & Mutations
for MC1R

Medical News
for MC1R

Publications
for MC1R

Search for MC1R

Genome Databases showing MC1R

Other Databases showing MC1R

Specialized Databases showing MC1R

Licensable Technologies
for MC1R

Services
for MC1R

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MC1R Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor MC1R

Summariesfor MC1R

Genomic Locationfor MC1R

Proteinsfor MC1R

Protein Domains/Familiesfor MC1R

Gene Functionfor MC1R

Pathways & Interactionsfor MC1R

Drugs & Compoundsfor MC1R

Transcriptsfor MC1R

Expression for MC1R

Orthologsfor MC1R

Paralogsfor MC1R

SNPs/Variantsfor MC1R

Disorders & Mutationsfor MC1R

Medical Newsfor MC1R

Publicationsfor MC1R

Search for MC1R

Genome Databases showing MC1R

Other Databases showing MC1R

Specialized Databases showing MC1R

Licensable Technologiesfor MC1R

Servicesfor MC1R

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MC1R

Summaries
for MC1R

Genomic Location
for MC1R

Proteins
for MC1R

Protein Domains/
Families
for MC1R

Gene Function
for MC1R

Pathways & Interactions
for MC1R

Drugs & Compounds
for MC1R

Transcripts
for MC1R

Expression
for MC1R

Orthologs
for MC1R

Paralogs
for MC1R

SNPs/Variants
for MC1R

Disorders & Mutations
for MC1R

Medical News
for MC1R

Publications
for MC1R

Licensable Technologies
for MC1R

Services
for MC1R