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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MBP Gene

protein-coding GIFtS: 67
GCID: GC18M074690

myelin basic protein

Explore 171 diseases affiliated with
MBP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Myelin Basic Protein¹ ²
Myelin A1 Protein² ³
Myelin Membrane Encephalitogenic Protein² ³

External Ids:	HGNC: 6925¹	Entrez Gene: 4155²	Ensembl: ENSG00000197971⁷	OMIM: 159430⁵	UniProtKB: P02686³

Export aliases for MBP gene to outside databases

Previous GC identifers: GC18M074281 GC18M074839 GC18M074453 GC18M072817 GC18M072819 GC18M071371

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MBP:

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann

cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune

system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons

located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites

gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to

Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence

linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized

myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription

unit is an integral part of the Golli transcription unit and that this arrangement is important for the function

and/or regulation of these genes. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MBP_HUMAN, P02686

Function: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of

the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might

have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms

(isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination,

maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural

cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of

isomers, with each of them potentially having a specialized function. Induces T-cell proliferation

Gene Wiki entry for MBP (Myelin basic protein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_025028.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MBP gene promoter:
PPAR-alpha AP-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MBP promoter sequence

Search SABiosciences Chromatin IP Primers for MBP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MBP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q23 Ensembl cytogenetic band: 18q23 HGNC cytogenetic band: 18q23

MBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MBP gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M074690: view genomic region (about GC identifiers)

Start:	74,690,783 bp from pter	End:	74,845,639 bp from pter
Size:	154,857 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MBP_HUMAN, P02686 (See protein sequence)

Recommended Name: Myelin basic protein

Size: 304 amino acids; 33117 Da

Subunit: Homodimer. Isoform 3 exists as a homodimer

Subcellular location: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin

Developmental stage: Expression begins abruptly in 14-16 week old fetuses. Even smaller isoforms seem to be produced

during embryogenesis; some of these persisting in the adult. Isoform 4 expression is more evident at 16 weeks and its

relative proportion declines thereafter

Sequence caution: Sequence=AAC41944.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The C-terminus

contains a Histidine tag; Sequence=BAD92223.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Sequence=CAH10359.1; Type=Miscellaneous discrepancy; Note=wrong intron-exon boundaries;

6 PDB 3D structures from and Proteopedia for MBP:

1BX2 (3D)

1FV1 (3D)

1HQR (3D)

1QCL (3D)

1YMM (3D)

1ZGL (3D)

Secondary accessions: A4FU54 A6NI84 A8MY86 A8MYL4 B3KY66 B7ZKS2 B7ZKS4 Q15337 Q15338 Q15339 Q15340

Q59GX3 Q65ZS4 Q6AI64 Q6FH37 Q6FI04 Q6PK23

Alternative splicing: 6 isoforms: P02686-1 P02686-2 P02686-3 P02686-4 P02686-5 P02686-6 (Initiator Met-1 is removed. Contains a N-acetylalanine at position 2)

Explore the universe of human proteins at neXtProt for MBP: NX_P02686

Post-translational modifications:

Several charge isomers of MBP; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4, C5, C6, C7,

C8-A and C8-B (the least cationic form); are produced as a result of optional PTM, such as phosphorylation,

deamidation of glutamine or asparagine, arginine citrullination and methylation. C8-A and C8-B contain each two mass

isoforms termed C8-A(H), C8-A(L), C8-B(H) and C8-B(L), (H) standing for higher and (L) for lower molecular weight. C3,

C4 and C5 are phosphorylated. The ratio of methylated arginine residues decreases during aging, making the protein

more cationic¹

The N-terminal alanine is acetylated (isoform 3, isoform 4, isoform 5 and isoform 6)¹

Arg-241 was found to be 6% monomethylated and 60% symmetrically dimethylated¹

Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P02686

MBP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001020252.1 NP_001020261.1 NP_001020263.1 NP_001020271.1 NP_001020272.1 NP_002376.1

ENSEMBL proteins:

ENSP00000372025 ENSP00000462734 ENSP00000380973 ENSP00000380964 ENSP00000380963

ENSP00000435243 ENSP00000352667 ENSP00000436830 ENSP00000462780 ENSP00000431267

ENSP00000380967 ENSP00000346545 ENSP00000431335 ENSP00000462758 ENSP00000434011

ENSP00000435641 ENSP00000462223 ENSP00000463780 ENSP00000463403 ENSP00000405882

ENSP00000432988 ENSP00000442393 ENSP00000436951 ENSP00000463137 ENSP00000435322

ENSP00000437063 ENSP00000380961 ENSP00000380958 ENSP00000462374 ENSP00000463164

ENSP00000348273

Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant MBP Protein
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for MBP
	OriGene Purified Proteins (see all 4): MBP OriGene Protein Over-expression Lysate (see all 7): MBP OriGene Custom Protein Services for MBP
	GenScript Custom Purified and Recombinant Proteins Services for MBP
	Novus Biologicals MBP Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for MBP
	Uscn Proteins for MBP

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0033269	internode region of axon	IEA	--
GO:0042995	cell projection	--	--
GO:0043025	neuronal cell body	IEA	--
GO:0043209	myelin sheath	--	--

MBP for ontologies About GeneDecksing

MBP Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MBP
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	Cell Signaling Technology (CST) Antibodies for MBP
	OriGene Antibodies (see all 3): MBP OriGene Custom Antibody Services for MBP
	GenScript Superior Antibodies for MBP
	Novus Biologicals MBP Antibodies
	Abcam antibodies for MBP
	Uscn Antibodies for MBP
	ThermoFisher Antibody for MBP

Assay Products for MBP:

	EMD Millipore Kits and Assays for the Analysis of MBP
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MBP
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MBP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MBP for domains About GeneDecksing

1 InterPro domain/family:

IPR000548 Myelin_BP

Graphical View of Domain Structure for InterPro Entry P02686

ProtoNet protein and cluster: P02686

1 Blocks protein family: IPB000548 Myelin basic protein

UniProtKB/Swiss-Prot: MBP_HUMAN, P02686

Similarity: Belongs to the myelin basic protein family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MBP_HUMAN, P02686

Function: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of

the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might

have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms

(isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination,

maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural

cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of

isomers, with each of them potentially having a specialized function. Induces T-cell proliferation

Genatlas biochemistry entry for MBP:

myelin,basic protein,major component of normal myelin of central nervous system,with three alternatively spliced

isoforms

miRNA Products:		OriGene 3'-UTR Clone (see all 6): MBP Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MBP
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate MBP (see all 22):
		hsa-miR-2052 hsa-miR-34b* hsa-miR-16-2* hsa-miR-1258 hsa-miR-3653 hsa-miR-132 hsa-miR-449a hsa-miR-1323

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MBP (see all 7) OriGene shRNA RFP: MBP OriGene siRNA: MBP
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MBP

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: MBP (NM_001633)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MBP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MBP
		Search LifeMap BioReagents cell lines for MBP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MBP

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002020	protease binding	IEA	--
GO:0019911	structural constituent of myelin sheath	IEA	--

MBP for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MBP:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Mbp^tm1Atc for MBP
11 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Mbp):

behavior/neurological	cellular	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism
immune system	mortality/aging	nervous system	normal	reproductive system
vision/eye

MBP for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Selected targets of C/EBPbeta

Selected targets of C/EBPbeta

1.00

Glial Cell Differentiation

Glial Cell Differentiation

1.00

Neural Crest Differentiation

Neural Crest Differentiation

1.00

G-protein signaling_Ras family GTPases in kinase cascades (scheme)

MAPK Cascade

0.44

Cell adhesion_ECM remodeling

Metalloproteases in connective tissue degradation

0.31

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for MBP

	Selected targets of C/EBPbeta
	Metalloproteases in connective tissue degradation

3 BioSystems Pathways for MBP

	Neural Crest Differentiation
	MAPK Cascade
	Glial Cell Differentiation

MBP for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MBP

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/74 Interacting proteins for MBP (P02686^{2, 3} ENSP00000348273⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 74)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APTX	Q7Z2E3²^,³, ENSP00000400806⁴	MINT-2860724 I2D: score=3 STRING: ENSP00000400806
ATN1	P54259²^,³, ENSP00000349076⁴	MINT-2860743 I2D: score=3 STRING: ENSP00000349076
MAPK1	P28482²^,³, ENSP00000215832⁴	MINT-4301912 I2D: score=1 STRING: ENSP00000215832
CALM1	P62158³	I2D: score=1
CALM2	P62158³	I2D: score=1

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	TAS	7504278
GO:0007268	synaptic transmission	TAS	2434243
GO:0007417	central nervous system development	TAS	2434243
GO:0008366	axon ensheathment	TAS	2434243
GO:0009636	response to toxin	IEA	--

MBP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MBP for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for MBP

Compounds for MBP available from Tocris Bioscience About this table

Compound	Action	CAS #
Myelin Basic Protein (87-99)	Major antigenic component implicated in the pathophysiology of multiple sclerosis	[118506-26-6]

1 HMDB Compound for MBP About this table

Compound	Synonyms	CAS #	PubMed Ids
3-O-Sulfogalactosylceramide (d18:1/24:0)	Sulfatide (d18:1/24:0) (see all 16)	151122-71-3	2480186

10/101 Novoseek chemical compound relationships for MBP gene (see all 101) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
2',3'-cyclic nucleotide	87.3	59	11279272 (2), 11356257 (2), 1964183 (1), 8416742 (1) (see all 39)
glatiramer acetate	78.9	106	9237101 (7), 7541725 (5), 10861011 (4), 8965119 (3) (see all 28)
copolymer i	69.6	9	1707304 (3), 1714060 (1), 11003134 (1)
cuprizone	62.8	5	18938062 (1), 20305752 (1), 17290413 (1)
threonine	59.4	24	1315774 (1), 14594813 (1), 1716348 (1), 1716457 (1) (see all 20)
benzophenone-3	55.6	9	7679413 (1), 16049372 (1), 7517457 (1), 11207660 (1) (see all 7)
sulfatide	55.4	22	18039685 (3), 9482258 (2), 1372178 (2), 12161033 (1) (see all 10)
sulf	54.4	12	9130259 (4), 1372178 (3), 12161033 (1)
citrulline	53.2	36	1707596 (2), 7683860 (2), 7507225 (2), 10675299 (2) (see all 15)
edss	50.1	3	9619641 (1), 9987755 (1)

Search CenterWatch for drugs/clinical trials and news about MBP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MBP gene (8 alternative transcripts):

NM_001025081.1 NM_001025090.1 NM_001025092.1 NM_001025100.1 NM_001025101.1 NM_002385.2 NM_001025094.1 NM_001025098.1

Unigene Cluster for MBP:

Myelin basic protein

Hs.551713 [show with all ESTs]

Unigene Representative Sequence: NM_001025100

18/48 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 48):

ENST00000382582 ENST00000490319(uc010dqz.3) ENST00000585201(uc010xfe.1)

ENST00000397875 ENST00000397866 ENST00000397865 ENST00000527041 ENST00000359645

ENST00000528160 ENST00000577755 ENST00000527975 ENST00000578715 ENST00000397869

ENST00000354542 ENST00000531144 ENST00000583474 ENST00000533278 ENST00000526111

miRNA Products:		OriGene 3'-UTR Clone (see all 6): MBP Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MBP
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate MBP (see all 22):
		hsa-miR-2052 hsa-miR-34b* hsa-miR-16-2* hsa-miR-1258 hsa-miR-3653 hsa-miR-132 hsa-miR-449a hsa-miR-1323

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MBP (see all 7) OriGene shRNA RFP: MBP OriGene siRNA: MBP
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MBP

Additional cDNA sequence:

AB208986.1 AK074315.1 AK093588.1 AK094611.1 AK095121.1 AK098402.1 AK098513.1 AK122594.1

AK123433.1 AK124830.1 AK126977.1 AK128770.1 AK128788.1 AK289893.1 AK293922.1 AK296492.1

AK314553.1 BC008749.2 BC030093.1 BC065248.1 BC068550.1 BC080654.1 BC101771.1 BC101773.1

BC130034.1 BC143348.1 BC143350.1 CR536534.1 CR541919.1 L18865.1 M13577.1 M30047.1

M30515.1 M30516.1

24/159 DOTS entries (see all 159):

DT.100889742 DT.101985667 DT.95223942 DT.95095286 DT.91848616 DT.95095349 DT.121101020 DT.121100766

DT.95310721 DT.100889773 DT.121100675 DT.100889749 DT.95211483 DT.121101087 DT.100889740 DT.91873487

DT.86855495 DT.121100576 DT.95164195 DT.100889757 DT.111002 DT.100889751 DT.100889768 DT.121100982

24/1185 AceView cDNA sequences (see all 1185):

BF727350 CB155773 BP349448 AV729124 CK431001 CF453545 AA348363 AL533010

AA321160 AA348829 CB153591 F06160 AA889895 AA348803 BM977303 BP360101

BQ893737 AA348606 CB155578 CB155812 AI580896 CB152243 AI128878 BI039212

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for MBP (see all 15) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	·	7e	^	8	^	9	^	10a	·	10b	·	10c	^	11	^	12a	·	12b	^	13a	·	13b	·	13c	^	14a	·	14b	·
SP1:																									-				-						-						-		-
SP2:																									-		-		-						-						-		-
SP3:																									-				-						-				-		-		-
SP4:																									-		-		-						-				-		-		-
SP5:																							-		-		-		-		-		-		-		-		-		-		-		-

ExUns:	14c	·	14d	^	15a	·	15b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for MBP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MBP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTATTAATA

About this image

MBP expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Bone

Zeugopod Growth Plate

Bone

Bone

Brain

Renal Collecting Duct System

Kidney

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

See MBP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MBP

SOURCE GeneReport for Unigene cluster: Hs.551713

UniProtKB/Swiss-Prot: MBP_HUMAN, P02686

Tissue specificity: MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP

isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune

system

SABiosciences Expression via Pathway-Focused PCR Arrays including MBP:

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Multiple Sclerosis in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MBP gene from 5/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mbp^{1 , 5}	myelin basic protein^{1, 5}	88.35(n)¹ 87.55(a)¹		18 (55.84 cM)⁵ 17196¹ NM_010777.3¹ NP_034907.1¹ 82475146⁵
chicken (Gallus gallus)	Aves	MBP¹	myelin basic protein	71.86(n) 73.65(a)		396217 NM_205280.1 NP_990611.1
lizard (Anolis carolinensis)	Reptilia	MBP⁶	--	43(a)	1 ↔ 1	4(50865105-50900400)
African clawed frog (Xenopus laevis)	Amphibia	Xl.25724²	Xenopus laevis mRNA for myelin basic protein, complete more	77.52(n)		AB000736.1
zebrafish (Danio rerio)	Actinopterygii	mbpb¹	myelin basic protein b	60.88(n) 55.37(a)		368319 XM_001923576.2 XP_001923611.1

ENSEMBL Gene Tree for MBP (if available)
TreeFam Gene Tree for MBP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs470319^1,2	C,F,A,	--	74690322(+)	`TAAGAT/GCCTGT`	5	--	ds500¹		8		NA WA EA	368
rs142004973^1,2	C,	--	74690349(+)	`AAAAC-/AAAAGAG`	5	--	ds500¹		0	--	--	--	--
rs186853844^1,2		--	74690349(+)	`AAAACA/GAAAGA`	5	--	ds500¹		0	--	--	--	--
rs144887594^1,2		--	74690357(+)	`AGAGAA/CTTTCG`	5	--	ds500¹		0	--	--	--	--
rs113169821^1,2	C,	--	74690361(+)	`ACTTTC/TGTCTA`	5	--	ds500¹		2		CSA WA	120
rs188601565^1,2		--	74690556(+)	`GAGACA/GCTAAA`	5	--	ds500¹		0	--	--	--	--
rs6565923^1,2	C,F,A,H,	--	74690596(+)	`CCTAAC/AAACTA`	5	--	ds500¹		11		NS EA NA WA	922
rs9965258^1,2	C,	--	74690680(+)	`GCCCTG/ACCTGG`	5	--	ds500¹		2		CSA WA	120
rs2276276^1,2	C,F,A,	--	74690684(+)	`TGCCTG/CGAGAC`	5	--	ds500¹		14		NA EA WA CSA	732
rs2276277^1,2	C,F,H,	--	74690700(+)	`GGCACC/TGAGTC`	5	--	ds500¹		32		NA NS EA WA	3268

HapMap Linkage Disequilibrium report for MBP (74690783 - 74845639 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for MBP
1 CNV: 102725
5 Indels: 45692 61643 26116 42949 102726

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MBP for disorders About GeneDecksing

OMIM gene information: 159430 OMIM disorders: --

UniProtKB/Swiss-Prot: MBP_HUMAN, P02686

Note=The reduction in the surface charge of citrullinated and/or methylated MBP could result in a weakened

attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as chronical

multiple sclerosis (MS), and fulminating MS (Marburg disease)

20/171 diseases for MBP (see all 171): About MalaCards

htlv-1 associated myelopathy/tropical spastic paraparesis htlv-1 associated myelopathy pelizaeus-merzbacher disease akinetic mutism

guillain-barre syndrome landau-kleffner syndrome central pontine myelinolysis tropical spastic paraparesis

neuromyelitis optica spinal cord injury malignant peripheral nerve sheath tumor relapsing-remitting multiple sclerosis

chiari malformation chronic inflammatory demyelinating polyradiculoneuropathy transverse myelitis niemann-pick disease

aids dementia complex ossifying fibromyxoid tumor acid sphingomyelinase deficiency subacute sclerosing panencephalitis

8 diseases from the University of Copenhagen DISEASES database for MBP:

Multiple sclerosis Acute disseminated encephalomyelitis Hypersensitivity reaction type II disease Brain disease

Neuropathy Measles Neuromyelitis optica Subacute sclerosing panencephalitis

10/96 Novoseek disease relationships for MBP gene (see all 96) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
multiple sclerosis	92.5	562	14714495 (7), 1690527 (4), 12465458 (4), 1694970 (4) (see all 99)
encephalomyelitis	89.8	187	7512579 (2), 7689596 (2), 7504090 (2), 15292513 (2) (see all 99)
demyelinating diseases	86.7	49	1384994 (2), 1718484 (1), 8632058 (1), 11234279 (1) (see all 30)
demyelination	85.6	88	19726693 (2), 7508580 (2), 12465458 (2), 7525334 (2) (see all 60)
18q- syndrome	74.4	5	8507907 (1), 9259379 (1), 8767586 (1), 14508777 (1)
autoimmune diseases	72.7	29	8393796 (1), 10377791 (1), 8590314 (1), 7692995 (1) (see all 20)
encephalomyelitis acute disseminated	70.6	2	12589368 (1), 17990580 (1)
optic neuritis	70.4	16	7510787 (2), 7515411 (2), 7513391 (1), 7524258 (1) (see all 10)
autoimmune response	69.8	29	1718484 (1), 7689820 (1), 7526591 (1), 9394837 (1) (see all 16)
myelin degeneration	63.6	5	20091409 (1), 9094982 (1), 16900293 (1), 19359623 (1) (see all 5)

Genetic Association Database (GAD): MBP
Human Genome Epidemiology (HuGE) Navigator: MBP (391 documents)

Export disorders for MBP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MBP gene, integrated from 9 sources (see all 1256):
(articles sorted by number of sources associating them with MBP)

Utopia: connect your pdf to the dynamic
world of online information

Identification of three forms of human myelin basic protein by cDNA cloning. (PubMed id 2425357)^{1, 2, 3} Kamholz J.... Lazzarini R.A. (1986)
[Polymorphism of length of tetranucleotide repeat from the 5'-side from the myelin basic protein gene in multiple sclerosis in Russians] (PubMed id 14714495)^{1, 4, 9} Andreevskii T.V....Favorova O.O. (2003)
Myelin basic protein gene is associated with MS in DR4- and DR5-positive Italians and Russians. (PubMed id 12939427)^{1, 4, 9} Guerini F.R....Favorova O.O. (2003)
The isolation and characterization of four myelin basic proteins from the unbound fraction during CM52 chromatography. (PubMed id 7574672)^{1, 2, 9} Boulias C.... Moscarello M.A. (1995)
Leukocyte gelatinase B cleavage releases encephalitogens from human myelin basic protein. (PubMed id 7685161)^{1, 2, 9} Proost P.... Opdenakker G. (1993)
Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule. (PubMed id 16079912)^{1, 2} Li Y.... Mariuzza R.A. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Genetic variation of mannose-binding protein associated with glomerular immune deposition in IgA nephropathy. (PubMed id 11940329)^{1, 4} Gong R....Li L. (2002)
[Mannose-binding protein gene polymorphism influences the patterns of glomerular immune deposition in IgA nephropathy] (PubMed id 11295122)^{1, 4} Gong R....Li L. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4155	HGNC: 6925	AceView: MBP	Ensembl:ENSG00000197971	euGenes: HUgn4155
ECgene: MBP	H-InvDB: MBP

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MBP	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Myelin_basic_protein

Intellectual Property for MBP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MBP gene:
Search GeneIP for patents involving MBP

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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Advanced Cell Diagnostics
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