Aliases for MBP Gene
Aliases for MBP Gene
External Ids for MBP Gene
- HGNC: 6925
- Entrez Gene: 4155
- Ensembl: ENSG00000197971
- OMIM: 159430
- UniProtKB: P02686
Previous GeneCards Identifiers for MBP Gene
- GC18M074281
- GC18M074839
- GC18M074453
- GC18M072817
- GC18M072819
- GC18M074690
- GC18M071371
Summaries for MBP Gene
-
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]
GeneCards Summary for MBP Gene
MBP (Myelin Basic Protein) is a Protein Coding gene. Diseases associated with MBP include Demyelinating Disease and Secondary Progressive Multiple Sclerosis. Among its related pathways are Spinal Cord Injury and Neuroscience. GO annotations related to this gene include protease binding and structural constituent of myelin sheath.
UniProtKB/Swiss-Prot for MBP Gene
-
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBP Gene
Genomics for MBP Gene
Regulatory Elements for MBP Gene
Enhancers for MBP Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MBP on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the MBP gene promoter:
Regulatory Element Products
Genomic Location for MBP Gene
- Chromosome:
- 18
- Start:
- 76,978,827 bp from pter
- End:
- 77,133,708 bp from pter
- Size:
- 154,882 bases
- Orientation:
- Minus strand
Genomic View for MBP Gene
Genes around MBP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q23 by Ensembl
- 18q23 by Entrez Gene
- 18q23 by HGNC
MBP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MBP Gene
Proteins for MBP Gene
-
Protein details for MBP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P02686-MBP_HUMAN
- Recommended name:
- Myelin basic protein
- Protein Accession:
- P02686
- A4FU54
- A6NI84
- A8MY86
- A8MYL4
- B3KY66
- B7ZKS2
- B7ZKS4
- Q15337
- Q15338
- Q15339
- Q15340
- Q59GX3
- Q65ZS4
- Q6AI64
- Q6FH37
- Q6FI04
- Q6PK23
Protein attributes for MBP Gene
- Size:
- 304 amino acids
- Molecular mass:
- 33117 Da
- Quaternary structure:
-
- Homodimer. Isoform 3 exists as a homodimer.
- SequenceCaution:
-
- Sequence=AAC41944.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The C-terminus contains a Histidine tag.; Evidence={ECO:0000305}; Sequence=BAD92223.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH10359.1; Type=Miscellaneous discrepancy; Note=wrong intron-exon boundaries.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for MBP Gene
Protein Expression for MBP Gene
Post-translational modifications for MBP Gene
- Arg-241 was found to be 6% monomethylated and 60% symmetrically dimethylated.
- Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1.
- Several charge isomers of MBP; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4, C5, C6, C7, C8-A and C8-B (the least cationic form); are produced as a result of optional PTM, such as phosphorylation, deamidation of glutamine or asparagine, arginine citrullination and methylation. C8-A and C8-B contain each two mass isoforms termed C8-A(H), C8-A(L), C8-B(H) and C8-B(L), (H) standing for higher and (L) for lower molecular weight. C3, C4 and C5 are phosphorylated. The ratio of methylated arginine residues decreases during aging, making the protein more cationic.
- The N-terminal alanine is acetylated (isoform 3, isoform 4, isoform 5 and isoform 6).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for MBP Gene
- ENSEMBL proteins:
-
- ENSP00000346545
- ENSP00000348273
- ENSP00000352667
- ENSP00000380958
- ENSP00000380961
- ENSP00000380963
- ENSP00000380964
- ENSP00000380967
- ENSP00000380973
- ENSP00000405882
- ENSP00000431267
- ENSP00000431335
- ENSP00000432988
- ENSP00000434011
- ENSP00000435243
- ENSP00000435322
- ENSP00000435641
- ENSP00000436830
- ENSP00000436951
- ENSP00000437063
- ENSP00000442393
- ENSP00000462223
- ENSP00000462374
- ENSP00000462734
- ENSP00000462758
- ENSP00000462780
- ENSP00000463137
- ENSP00000463164
- ENSP00000463403
- ENSP00000463780
- ENSP00000372025
- REFSEQ proteins:
Antibody Products
- EMD Millipore top MBP Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for MBP
- R&D Systems Antibodies for MBP (MBP)
- Cell Signaling Technology (CST) Antibodies for MBP (MBP)
- Novus Biologicals Antibodies for MBP
-
Cloud-Clone Corp. Antibodies for MBP
- Invitrogen Antibodies for MBP
- antibodies-online Antibodies for MBP: See all 223
- GeneTex MBP antibody for MBP
-
Custom Antibody ServicesProSci Antibodies for MBP
-
Santa Cruz Biotechnology (SCBT) Antibodies for MBP
Protein Products
- EMD Millipore Purified and/or Recombinant MBP Protein
- Enzo Life Sciences proteins for MBP
- Search Origene for MassSpec and Protein Over-expression Lysates for MBP
- Origene Custom Protein Services for MBP
-
Cloud-Clone Corp. Proteins for MBP
- antibodies-online Proteins for MBP: See all 35
- Search antibodies-online for peptides
- Search GeneTex for Proteins for MBP
Assay Products
- EMD Millipore Kits and Assays for MBP
- R&D Systems ELISAs and other biochemical assays for MBP (MBP)
- antibodies-online Kits for MBP: See all 54
No data available for DME Specific Peptides for MBP Gene
Domains & Families for MBP Gene
Protein Domains for MBP Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MBP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P02686- Family:
-
- Belongs to the myelin basic protein family.
No data available for Gene Families for MBP Gene
Function for MBP Gene
Molecular function for MBP Gene
- GENATLAS Biochemistry:
- myelin,basic protein,major component of normal myelin of central nervous system,with three alternatively spliced isoforms
- UniProtKB/Swiss-Prot Function:
- The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002020 | protease binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0005516 | calmodulin binding | IPI | 19855925 |
| GO:0019911 | structural constituent of myelin sheath | IEA | -- |
Phenotypes for MBP Gene
- MGI mutant phenotypes for MBP:
-
inferred from 6 alleles
- mortality/aging
- cellular phenotype
- behavior/neurological phenotype
- normal phenotype
- growth/size/body region phenotype
- immune system phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- hematopoietic system phenotype
- GenomeRNAi human phenotypes for MBP:
-
- Increased viability
- Increased gamma-H2AX phosphorylation
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased IL-8 secretion
- Weakly decreased NFAT1-GFP nuclear translocation
- Negative genetic interaction between BLM-/- and BLM+/+
Animal Models for MBP Gene
- MGI Knock Outs for MBP:
-
- Mbp tm1Atc
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MBP
-
- Search ViGene Biosciences for MBP
CRISPR Products
-
OriGene CRISPR knockouts for MBP
-
Santa Cruz Biotechnology (SCBT) CRISPR for MBP
- GenScript: Design CRISPR guide RNA sequences for MBP
miRNA for MBP Gene
- miRTarBase miRNAs that target MBP
miRNA Products
- Search ViGene Biosciences for MBP
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for MBP
- Browse OriGene Inhibitory RNA Products For MBP
Clone Products
- Sino Biological Human cDNA Clone for MBP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MBP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MBP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for MBP
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA4-12730) for MBP
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MBP Gene
Localization for MBP Gene
Subcellular locations from UniProtKB/Swiss-Prot for MBP Gene
- Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.
- Isoform 3: Nucleus. Note=Targeted to nucleus in oligodendrocytes.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| cytoskeleton | 4 |
| nucleus | 4 |
| cytosol | 3 |
| extracellular | 2 |
| mitochondrion | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IDA | 22524708 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0033269 | internode region of axon | IEA | -- |
Pathways & Interactions for MBP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Neuroscience | ||
| 2 | Glial Cell Differentiation | ||
| 3 | G-protein signaling Ras family GTPases in kinase cascades (scheme) |
.44
|
|
| 4 | MECP2 and Associated Rett Syndrome | ||
| 5 | Neural Crest Differentiation | ||
Pathways by source for MBP Gene
1 Cell Signaling Technology pathway for MBP Gene
6 BioSystems pathways for MBP Gene
Interacting Proteins for MBP Gene
Selected Interacting proteins:
P02686-MBP_HUMAN
ENSP00000372025
for MBP Gene via
MINT
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IDA | 22524708 |
| GO:0006955 | immune response | TAS | 7504278 |
| GO:0007268 | chemical synaptic transmission | TAS | 2434243 |
| GO:0007417 | central nervous system development | TAS | 2434243 |
| GO:0007605 | sensory perception of sound | IEA | -- |
Drugs & Compounds for MBP Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Myelin Basic Protein (68-82), guinea pig | Pharma | 0 | ||||
| Myelin Basic Protein (87-99) | Pharma | Encephalitogenic peptide | 0 | |||
| ATX-MS-1467 | Pharma | 0 | ||||
| MOG (35-55) | Pharma | Minor component of CNS myelin, Encephalitogenic myelin oligodendrocyte glycoprotein fragment | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 3-O-Sulfogalactosylceramide (d18:1/24:0) |
|
151122-71-3 | ||||
| C3bot (154-182) |
|
1246280-79-4 |
|
|
||
| Nogo-66 (1-40) |
|
475221-20-6 |
|
|
||
| ONO 2506 |
|
185517-21-9 |
|
|
||
| PLP (139-151) |
|
122018-58-0 |
|
|
(5) Tocris Compounds for MBP Gene
| Compound | Action | Cas Number |
|---|---|---|
| C3bot (154-182) | Neurotrophic fragment of clostridial C3 protein | 1246280-79-4 |
| MOG (35-55) | Encephalitogenic myelin oligodendrocyte glycoprotein fragment | 149635-73-4 |
| Nogo-66 (1-40) | Competitive antagonist for Nogo-66 receptor; promotes neuron regeneration | 475221-20-6 |
| ONO 2506 | Inhibits S-100beta synthesis; neuroprotective | 185517-21-9 |
| PLP (139-151) | Encephalitogenic myelin proteolipid fragment | 122018-58-0 |
(2) ApexBio Compounds for MBP Gene
| Compound | Action | Cas Number |
|---|---|---|
| Myelin Basic Protein (68-82), guinea pig | 98474-59-0 | |
| Myelin Basic Protein (87-99) | Encephalitogenic peptide | 118506-26-6 |
Drug Products
- ApexBio compounds for MBP
Transcripts for MBP Gene
mRNA/cDNA for MBP Gene
- (12) REFSEQ mRNAs :
- (34) Additional mRNA sequences :
- (1185) Selected AceView cDNA sequences:
- (48) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MBP Gene
- Myelin basic protein:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MBP
-
Santa Cruz Biotechnology (SCBT) CRISPR for MBP
- GenScript: Design CRISPR guide RNA sequences for MBP
miRNA Products
- Search ViGene Biosciences for MBP
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for MBP
- Browse OriGene Inhibitory RNA Products For MBP
Clone Products
- Sino Biological Human cDNA Clone for MBP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MBP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MBP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA4-12730) for MBP
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - |
| ExUns: | 14c | · | 14d | ^ | 15a | · | 15b |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | |||||||
| SP3: | |||||||
| SP4: | |||||||
| SP5: | |||||||
| SP6: | |||||||
| SP7: | |||||||
| SP8: | |||||||
| SP9: | |||||||
| SP10: | - | - | |||||
| SP11: | |||||||
| SP12: | |||||||
| SP13: | |||||||
| SP14: | |||||||
| SP15: |
Expression for MBP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Oligodendrocyte Precursor Cells Forebrain White Matter
- Adult Endothelial Cells Blood Brain Barrier
- Hypothalamus
- Thalamus
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Myelinating Schwann Cells Peripheral Nerve Domain
- Myelinating Oligodendrocyte Cells Spinal Cord White Matter
- Oligodendrocyte-like cells (Wang S et. al. 2013)
- B27-induced oligodendrocyte-like cells(Sundberg M et. al. 2010)
- Spinal Cord (Nervous System)
-
Peripheral Nervous System (Nervous System)
- Immature Schwann Cells Peripheral Nerve Domain
- Myelinating Schwann Cells Peripheral Nerve Domain
- Schwann-like cells(McKenzie IA et. al. 2006)
- Schwann-like cells(Pomp O et. al. 2008)
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- T Helper Cells Thymus
- Eosinophil Progenitors Hematopoietic Bone Marrow
- Bone (Muscoskeletal System)
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
- Gonad
- Kidney (Urinary System)
- Inner Cell Mass (Early Embryonic Tissues)
-
Ovary (Reproductive System)
- Cumulus Cells Antral Follicle
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
-
Liver (Hepatobiliary System)
- Mature Mesothelial Cells Liver Lobule
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Endothelium (Cardiovascular System)
- Adult Endothelial Cells Blood Brain Barrier
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Neural Tube (Nervous System)
- Heart (Cardiovascular System)
- NULL (Uncategorized)
- Germ Cells (Reproductive System)
- Oligodendrocytes (Nervous System)
mRNA differential expression in normal tissues according to GTEx for MBP Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x22.1), Brain - Substantia nigra (x8.0), Brain - Hippocampus (x4.1), and Brain - Hypothalamus (x4.1).
This gene is overexpressed in Spinal cord (37.6), Frontal cortex (16.5), and Brain (14.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MBP Gene
NURSA nuclear receptor signaling pathways regulating expression of MBP Gene:
MBPSOURCE GeneReport for Unigene cluster for MBP Gene:
Hs.551713mRNA Expression by UniProt/SwissProt for MBP Gene:
P02686-MBP_HUMAN
Tissue specificity:
MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.
Evidence on tissue expression from TISSUES for MBP Gene
- Kidney(5)
- Nervous system(5)
- Skin(4.9)
- Lung(4.5)
- Eye(3.5)
- Blood(3.3)
- Spleen(2.9)
- Lymph node(2.8)
- Muscle(2.8)
- Thyroid gland(2.4)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs for MBP
-
OriGene qPCR primer pairs and template standards for MBP
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MBP Gene
Orthologs for MBP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MBP 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Mbp 34 16 35 |
|
||
| dog (Canis familiaris) |
Mammalia | MBP 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | MBP 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MBP 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MBP 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MBP 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MBP 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mbp 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.25724 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mbpb 34 35 |
|
- Species where no ortholog for MBP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MBP Gene
No data available for Paralogs for MBP Gene
Variants for MBP Gene
| SNP ID | Clin | Chr 18 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000001600 | -- | 77,073,734(+) | GGACA(G/T)GCAGA | intron-variant | |
| rs1000003982 | -- | 77,068,016(+) | CATCC(C/T)GTGTG | intron-variant | |
| rs1000010918 | -- | 77,035,319(+) | TGTAC(A/G)CCCTT | intron-variant | |
| rs1000041881 | -- | 76,993,584(+) | CATTT(G/T)ATCCC | intron-variant | |
| rs1000061231 | -- | 77,068,203(+) | GAGGA(C/G)GGAAG | intron-variant |
Residual Variation Intolerance Score:
78.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.17;
51.80% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for MBP Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MBP Gene
Disorders for MBP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| demyelinating disease |
|
|
| secondary progressive multiple sclerosis |
|
|
| guillain-barre syndrome |
|
|
| central pontine myelinolysis |
|
|
| optic neuritis |
|
Search MBP in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MBP_HUMAN- Note=The reduction in the surface charge of citrullinated and/or methylated MBP could result in a weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as chronical multiple sclerosis (MS), and fulminating MS (Marburg disease).
Relevant External Links for MBP
No data available for Genatlas for MBP Gene
Publications for MBP Gene
- Pharmacogenetics of glatiramer acetate therapy for multiple sclerosis reveals drug-response markers. (PMID: 17622942) Grossman I. … Miller A. (Pharmacogenet. Genomics 2007) 3 22 46 64
- Myelin basic protein gene is associated with MS in DR4- and DR5-positive Italians and Russians. (PMID: 12939427) Guerini F.R. … Favorova O.O. (Neurology 2003) 3 22 46 64
- The isolation and characterization of four myelin basic proteins from the unbound fraction during CM52 chromatography. (PMID: 7574672) Boulias C. … Moscarello M.A. (Arch. Biochem. Biophys. 1995) 3 4 22 64
- Identification of three forms of human myelin basic protein by cDNA cloning. (PMID: 2425357) Kamholz J. … Lazzarini R.A. (Proc. Natl. Acad. Sci. U.S.A. 1986) 2 3 4 64
- Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
Products for MBP Gene
- Browse Small Molecules at EMD Millipore
- EMD Millipore top MBP Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for MBP
- EMD Millipore Purified and/or Recombinant MBP Protein
- EMD Millipore Kits and Assays for MBP
- EMD Millipore genomic analysis products
- R&D Systems Antibodies for MBP (MBP)
- Browse R&D Systems for Human Recombinant Proteins
- R&D Systems ELISAs and other biochemical assays for MBP (MBP)
- Browse Primary Antibodies
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- Custom Antibody ServicesOriGene Antibodies for MBP
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for MBP
- Origene Custom Protein Services for MBP
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for MBP
- Browse OriGene Inhibitory RNA Products For MBP
- OriGene qPCR primer pairs and template standards for MBP
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for MBP in any vector
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- Cell Signaling Technology (CST) Antibodies for MBP (MBP)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for MBP
- Browse Sino Biological Cell Lysates
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- Sino Biological Antibodies
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for MBP
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- Cloud-Clone Corp. Antibodies for MBP
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- Invitrogen Antibodies for MBP
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- antibodies-online Antibodies for MBP: See all 223
- antibodies-online Kits for MBP: See all 54
- antibodies-online Proteins for MBP: See all 35
- Search antibodies-online for peptides
- GeneTex MBP antibody for MBP
- Search GeneTex for Proteins for MBP
- Search ViGene Biosciences for MBP
- Santa Cruz Biotechnology (SCBT) Antibodies for MBP
- Search Santa Cruz Biotechnology (SCBT) for MBP siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MBP
- Custom Antibody ServicesProSci Antibodies for MBP
- Search for MBP Proteins at ProSci
- Horizon Cell Lines for MBP
- Cyagen custom Knockout/knockin (KOKI) mouse models for MBP
- VectorBuilder custom plasmid, inducible vectors for MBP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MBP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MBP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (26) UniGene
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- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
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- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
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- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
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- (99) Illumina
- (100) COMPARTMENTS
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- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
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- (154) TISSUES
- (155) Gene ORGANizer