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Set Analyses:

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MBP Gene

protein-coding GIFtS: 65
GCID: GC18M074690

Myelin Basic Protein

Microbiology & Infectious Diseases Congress

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Myelin Basic Protein¹ ²
Myelin A1 Protein² ³
Myelin Membrane Encephalitogenic Protein² ³

External Ids:	HGNC: 6925¹	Entrez Gene: 4155²	Ensembl: ENSG00000197971⁷	OMIM: 159430⁵	UniProtKB: P02686³

ORGUL members:

Export aliases for MBP gene to outside databases

Previous GC identifers: GC18M074281 GC18M074839 GC18M074453 GC18M072817 GC18M072819 GC18M071371

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MBP Gene:

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and

Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the

immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional

exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription

start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons

unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal

Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce

the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting

that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is

important for the function and/or regulation of these genes. (provided by RefSeq, Jul 2008)

GeneCards Summary for MBP Gene:

MBP (myelin basic protein) is a protein-coding gene. Diseases associated with MBP include munchausen by proxy, and autoimmune disease of the nervous system. GO annotations related to this gene include protease binding and structural constituent of myelin sheath.

UniProtKB/Swiss-Prot: MBP_HUMAN, P02686

Function: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein

components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The

smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The

non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early

developing brain long before myelination, maybe as components of transcriptional complexes, and may also be

involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional

post-translational modifications give a wide spectrum of isomers, with each of them potentially having a

specialized function. Induces T-cell proliferation

Gene Wiki entry for MBP (Myelin basic protein) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000018.10 NT_010966.15 NC_018929.2

Regulatory elements:

Regulatory transcription factor binding sites in the MBP gene promoter:
PPAR-alpha AP-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MBP promoter sequence

Search Chromatin IP Primers for MBP

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MBP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q23 Ensembl cytogenetic band: 18q23 HGNC cytogenetic band: 18q23

MBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MBP gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M074690: view genomic region (about GC identifiers)

Start:	74,690,783 bp from pter	End:	74,845,639 bp from pter
Size:	154,857 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MBP_HUMAN, P02686 (See protein sequence)

Recommended Name: Myelin basic protein

Size: 304 amino acids; 33117 Da

Subunit: Homodimer. Isoform 3 exists as a homodimer

Developmental stage: Expression begins abruptly in 14-16 week old fetuses. Even smaller isoforms seem to be

produced during embryogenesis; some of these persisting in the adult. Isoform 4 expression is more evident at 16

weeks and its relative proportion declines thereafter

Sequence caution: Sequence=AAC41944.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The C-terminus

contains a Histidine tag; Sequence=BAD92223.1; Type=Erroneous initiation; Note=Translation N-terminally

shortened; Sequence=CAH10359.1; Type=Miscellaneous discrepancy; Note=wrong intron-exon boundaries;

6 PDB 3D structures from and Proteopedia for MBP:

1BX2 (3D)

1FV1 (3D)

1HQR (3D)

1QCL (3D)

1YMM (3D)

1ZGL (3D)

Secondary accessions: A4FU54 A6NI84 A8MY86 A8MYL4 B3KY66 B7ZKS2 B7ZKS4 Q15337 Q15338 Q15339

Q15340 Q59GX3 Q65ZS4 Q6AI64 Q6FH37 Q6FI04 Q6PK23

Alternative splicing: 6 isoforms: P02686-1 P02686-2 P02686-3 P02686-4 P02686-5 P02686-6 (Initiator Met-1 is removed. Contains a N-acetylalanine at position 2)

Explore the universe of human proteins at neXtProt for MBP: NX_P02686

Explore proteomics data for MBP at MOPED

Post-translational modifications:

Several charge isomers of MBP; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4, C5, C6,

C7, C8-A and C8-B (the least cationic form); are produced as a result of optional PTM, such as phosphorylation,

deamidation of glutamine or asparagine, arginine citrullination and methylation. C8-A and C8-B contain each two

mass isoforms termed C8-A(H), C8-A(L), C8-B(H) and C8-B(L), (H) standing for higher and (L) for lower molecular

weight. C3, C4 and C5 are phosphorylated. The ratio of methylated arginine residues decreases during aging,

making the protein more cationic¹

The N-terminal alanine is acetylated (isoform 3, isoform 4, isoform 5 and isoform 6)¹

Arg-241 was found to be 6% monomethylated and 60% symmetrically dimethylated¹

Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1¹

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See MBP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (6 alternative transcripts):

NP_001020252.1 NP_001020261.1 NP_001020263.1 NP_001020271.1 NP_001020272.1 NP_002376.1

ENSEMBL proteins:

ENSP00000372025 ENSP00000462734 ENSP00000380973 ENSP00000380964 ENSP00000380963

ENSP00000435243 ENSP00000352667 ENSP00000436830 ENSP00000462780 ENSP00000431267

ENSP00000380967 ENSP00000346545 ENSP00000431335 ENSP00000462758 ENSP00000434011

ENSP00000435641 ENSP00000462223 ENSP00000463780 ENSP00000463403 ENSP00000405882

ENSP00000432988 ENSP00000442393 ENSP00000436951 ENSP00000463137 ENSP00000435322

ENSP00000437063 ENSP00000380961 ENSP00000380958 ENSP00000462374 ENSP00000463164

ENSP00000348273

MBP Human Recombinant Protein Products:

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	Novus Biologicals MBP Proteins Novus Biologicals MBP Lysates
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MBP Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MBP
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	Novus Biologicals MBP Antibodies
	Abcam antibodies for MBP
	Cloud-Clone Corp. Antibodies for MBP
	ThermoFisher Antibody for MBP
	LSBio Antibodies in human, mouse, rat for MBP

MBP Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MBP
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for MBP Cloud-Clone Corp. CLIAs for MBP

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:

IPR000548 Myelin_BP

Graphical View of Domain Structure for InterPro Entry P02686

ProtoNet protein and cluster: P02686

1 Blocks protein domain: IPB000548 Myelin basic protein

UniProtKB/Swiss-Prot: MBP_HUMAN, P02686

Similarity: Belongs to the myelin basic protein family

MBP for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: MBP_HUMAN, P02686

Function: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein

components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The

smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The

non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early

developing brain long before myelination, maybe as components of transcriptional complexes, and may also be

involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional

post-translational modifications give a wide spectrum of isomers, with each of them potentially having a

specialized function. Induces T-cell proliferation

Genatlas biochemistry entry for MBP:

myelin,basic protein,major component of normal myelin of central nervous system,with three alternatively spliced

isoforms

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002020	protease binding	IEA	--
GO:0005515	protein binding	IPI	17064692
GO:0019911	structural constituent of myelin sheath	IEA	--

MBP for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for MBP:

Increased gamma-H2AX phosphory

11 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Mbp):

behavior/neurological	cellular	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism
immune system	mortality/aging	nervous system	normal	reproductive system
vision/eye

MBP for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Mbp^tm1Atc for MBP

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MBP

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MBP

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MBP

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MBP

miRNA Products:		Block miRNA regulation of human, mouse, rat MBP using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MBP (see all 22):
		hsa-miR-2052 hsa-miR-34b* hsa-miR-16-2* hsa-miR-1258 hsa-miR-3653 hsa-miR-132 hsa-miR-449a hsa-miR-1323

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MBP
		Predesigned siRNA for gene silencing in human, mouse, rat MBP

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MBP

Clone Products:		OriGene clones in human, mouse for MBP (see all 34) OriGene ORF clones in mouse, rat for MBP OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MBP (NM_001633)
		Sino Biological Human cDNA Clone for MBP
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MBP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MBP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MBP
		Browse ESI BIO Cell Lines and PureStem Progenitors for MBP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MBP

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

MBP_HUMAN, P02686: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of

myelin

MBP_HUMAN, P02686: Isoform 3: Nucleus. Note=Targeted to nucleus in oligodendrocytes

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	3
plasma membrane	3
cytosol	2
extracellular	2
nucleus	2
endoplasmic reticulum	1
mitochondrion	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0033269	internode region of axon	IEA	--
GO:0042995	cell projection	--	--
GO:0043025	neuronal cell body	IEA	--

MBP for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MBP About (see all 6)

See pathways by source

SuperPath

Contained pathways About

G protein signaling Ras family GTPases in kinase cascades scheme

MAPK Cascade

0.44

Cell adhesion ECM remodeling

Metalloproteases in connective tissue degradation

0.31

Spinal Cord Injury

Spinal Cord Injury

Selected targets of C EBPbeta

Selected targets of C EBPbeta

Neural Crest Differentiation

Neural Crest Differentiation

4 BioSystems Pathways for MBP

	Spinal Cord Injury
	Neural Crest Differentiation
	MAPK Cascade
	Glial Cell Differentiation

Pathway & Disease-focused RT² Profiler PCR Arrays including MBP:

Terminal Differentiation Markers in human mouse rat

Multiple Sclerosis in human mouse rat

Interactions:

GeneGlobe Interaction Network for MBP

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for MBP (P02686^{1, 2, 3} ENSP00000348273⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 90)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APTX	Q7Z2E3²^,³, ENSP00000400806⁴	MINT-2860724 I2D: score=3 STRING: ENSP00000400806
ATN1	P54259²^,³, ENSP00000349076⁴	MINT-2860743 I2D: score=3 STRING: ENSP00000349076
MAPK1	P28482²^,³, ENSP00000215832⁴	MINT-4301912 I2D: score=1 STRING: ENSP00000215832
ENSG00000206308	P01903³, ENSP00000372746⁴	I2D: score=2 STRING: ENSP00000372746
HLA-DRA	P01903³, ENSP00000378786⁴	I2D: score=2 STRING: ENSP00000378786

About this table

Gene Ontology (GO): Selected biological process terms (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	TAS	7504278
GO:0007268	synaptic transmission	TAS	2434243
GO:0007417	central nervous system development	TAS	2434243
GO:0008366	axon ensheathment	TAS	2434243
GO:0009636	response to toxic substance	IEA	--

MBP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for MBP

Browse compounds at ApexBio

Compounds for MBP available from Tocris Bioscience About this table

Compound	Action	CAS #
PLP (139-151)	Encephalitogenic myelin proteolipid fragment	[122018-58-0]
ONO 2506	Inhibits S100B synthesis; neuroprotective	[185517-21-9]
C3bot (154-182)	Neurotrophic fragment of clostridial C3 protein	[1246280-79-4]
MOG (35-55)	Encephalitogenic myelin oligodendrocyte glycoprotein fragment	[149635-73-4]
Nogo-66 (1-40)	Competitive antagonist for Nogo-66 receptor; promotes neuron regeneration	[475221-20-6]

1 HMDB Compound for MBP About this table

Compound	Synonyms	CAS #	PubMed Ids
3-O-Sulfogalactosylceramide (d18:1/24:0)	Sulfatide (d18:1/24:0) (see all 16)	151122-71-3	2480186

Selected Novoseek inferred chemical compound relationships for MBP gene (see all 101) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
2',3'-cyclic nucleotide	87.3	59	11279272 (2), 11356257 (2), 1964183 (1), 8416742 (1) (see all 39)
glatiramer acetate	78.9	106	9237101 (7), 7541725 (5), 10861011 (4), 8965119 (3) (see all 28)
copolymer i	69.6	9	1707304 (3), 1714060 (1), 11003134 (1)
cuprizone	62.8	5	18938062 (1), 20305752 (1), 17290413 (1)
threonine	59.4	24	1315774 (1), 14594813 (1), 1716348 (1), 1716457 (1) (see all 20)
benzophenone-3	55.6	9	7679413 (1), 16049372 (1), 7517457 (1), 11207660 (1) (see all 7)
sulfatide	55.4	22	18039685 (3), 9482258 (2), 1372178 (2), 12161033 (1) (see all 10)
sulf	54.4	12	9130259 (4), 1372178 (3), 12161033 (1)
citrulline	53.2	36	1707596 (2), 7683860 (2), 7507225 (2), 10675299 (2) (see all 15)
edss	50.1	3	9619641 (1), 9987755 (1)

MBP for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MBP gene (8 alternative transcripts):

NM_001025081.1 NM_001025090.1 NM_001025092.1 NM_001025100.1 NM_001025101.1 NM_002385.2 NM_001025094.1 NM_001025098.1

Unigene Cluster for MBP:

Myelin basic protein

Hs.551713 [show with all ESTs]

Unigene Representative Sequence: NM_001025100

Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 48):

ENST00000382582 ENST00000490319(uc010dqz.3) ENST00000585201(uc010xfe.1)

ENST00000397875 ENST00000397866 ENST00000397865 ENST00000527041 ENST00000359645

ENST00000528160 ENST00000577755 ENST00000527975 ENST00000578715 ENST00000397869

ENST00000354542 ENST00000531144 ENST00000583474 ENST00000533278 ENST00000526111

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		Block miRNA regulation of human, mouse, rat MBP using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MBP (see all 22):
		hsa-miR-2052 hsa-miR-34b* hsa-miR-16-2* hsa-miR-1258 hsa-miR-3653 hsa-miR-132 hsa-miR-449a hsa-miR-1323

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MBP
		Predesigned siRNA for gene silencing in human, mouse, rat MBP

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		GenScript: all cDNA clones in your preferred vector: MBP (NM_001633)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MBP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MBP

Primer Products:		OriGene qPCR primer pairs and template standards for MBP OriGene qSTAR qPCR primer pairs in human, mouse for MBP
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat MBP
		QuantiTect SYBR Green Assays in human, mouse, rat MBP
		QuantiFast Probe-based Assays in human, mouse, rat MBP

Additional mRNA sequence:

AB208986.1 AK074315.1 AK093588.1 AK094611.1 AK095121.1 AK098402.1 AK098513.1 AK122594.1

AK123433.1 AK124830.1 AK126977.1 AK128770.1 AK128788.1 AK289893.1 AK293922.1 AK296492.1

AK314553.1 BC008749.2 BC030093.1 BC065248.1 BC068550.1 BC080654.1 BC101771.1 BC101773.1

BC130034.1 BC143348.1 BC143350.1 CR536534.1 CR541919.1 L18865.1 M13577.1 M30047.1

M30515.1 M30516.1

Selected DOTS entries (see all 159):

DT.100889742 DT.101985667 DT.95223942 DT.95095286 DT.91848616 DT.95095349 DT.121101020 DT.121100766

DT.95310721 DT.100889773 DT.121100675 DT.100889749 DT.95211483 DT.121101087 DT.100889740 DT.91873487

DT.86855495 DT.121100576 DT.95164195 DT.100889757 DT.111002 DT.100889751 DT.100889768 DT.121100982

Selected AceView cDNA sequences (see all 1185):

BE677395 BM931305 AK124830 CB154972 H44561 AA348748 CD514400 AA321162

AA332866 BU151039 AW118326 BQ058155 CB152985 AA434553 CB153096 AI379430

CB152227 CF455220 BX953029 F01798 CD514255 BF056430 AI866444 AW206642

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for MBP (see all 15) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	·	7e	^	8	^	9	^	10a	·	10b	·	10c	^	11	^	12a	·	12b	^	13a	·	13b	·	13c	^	14a	·	14b	·
SP1:																									-				-						-						-		-
SP2:																									-		-		-						-						-		-
SP3:																									-				-						-				-		-		-
SP4:																									-		-		-						-				-		-		-
SP5:																							-		-		-		-		-		-		-		-		-		-		-		-

ExUns:	14c	·	14d	^	15a	·	15b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for MBP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MBP expression in normal human tissues (normalized intensities) MBP embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TCTATTAATA

About this image

MBP expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 21) fully expand


Brain (Nervous System) fully expand to see all 16 entries
Myelinating Oligodendrocyte Cells Forebrain White Matter
Thalamus
Oligodendrocyte-like cells

Spinal Cord (Nervous System) fully expand to see all 6 entries
Myelinating Oligodendrocyte Cells Spinal Cord White Matter
Oligodendrocyte-like cells

Oligodendrocytes (Nervous System) fully expand to see all 5 entries
Oligodendrocyte-like cells

Peripheral Nervous System (Nervous System) fully expand to see all 4 entries
Myelinating Schwann Cells Peripheral Nerve Domain
Schwann-like cells

Schwann Cells (Nervous System) fully expand to see all 2 entries
Schwann-like cells

MBP Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

MBP Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.551713

UniProtKB/Swiss-Prot: MBP_HUMAN, P02686

Tissue specificity: MBP isoforms are found in both the central and the peripheral nervous system, whereas

Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from

the immune system

Pathway & Disease-focused RT² Profiler PCR Arrays including MBP:

Terminal Differentiation Markers in human mouse rat

Multiple Sclerosis in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MBP gene from Selected species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mbp^{1 , 5}	myelin basic protein^{1, 5}	88.35(n)¹ 87.55(a)¹		18 (55.84 cM)⁵ 17196¹ NM_010777.3¹ NP_034907.1¹ 82475146⁵
chicken (Gallus gallus)	Aves	MBP¹	myelin basic protein	71.66(n) 73.65(a)		396217 NM_205280.1 NP_990611.1
lizard (Anolis carolinensis)	Reptilia	MBP⁶	myelin basic protein	42(a)	1 ↔ 1	4(50865105-50973289)
African clawed frog (Xenopus laevis)	Amphibia	Xl.25724²	Xenopus laevis mRNA for myelin basic protein, complete more	77.52(n)		AB000736.1
zebrafish (Danio rerio)	Actinopterygii	mbpb¹	myelin basic protein b	61.48(n) 54.92(a)		368319 NM_001271459.1 NP_001258388.1

ENSEMBL Gene Tree for MBP (if available)
TreeFam Gene Tree for MBP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114844634^1,2	F	--	71411579(+)	`CCTGTG/AAGTGT`	4	--	us2k¹		1		WA	118
rs140007773^1,2		--	71411649(+)	`AGTAGA/GGTGGG`	4	--	us2k¹		0	--	--	--	--
rs60090446^1,2	C	--	74683074(+)	`ACCCT-/GTCTGTG`	2	--	int¹		1		NA	2
rs470319^1,2	C,F,A	--	74690322(+)	`TAAGAT/GCCTGT`	5	--	ds500¹		8		NA WA EA	368
rs35190126^1,2	C	--	74690349(+)	`AAAAC-/AAAAGAG`	5	--	ds500¹		0	--	--	--	--
rs186853844^1,2		--	74690349(+)	`AAAACA/GAAAGA`	5	--	ds500¹		0	--	--	--	--
rs144887594^1,2		--	74690357(+)	`AGAGAA/CTTTCG`	5	--	ds500¹		0	--	--	--	--
rs113169821^1,2	C,F	--	74690361(+)	`ACTTTC/TGTCTA`	5	--	ds500¹		2		CSA WA	120
rs145779350^1,2	C	--	74690524(+)	`AGAAC-/ACAG ACAGA`	5	--	ds500¹		0	--	--	--	--
rs188601565^1,2		--	74690556(+)	`GAGACA/GCTAAA`	5	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MBP (74690783 - 74845639 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for MBP (see all 29): About this table

Variant ID	Type	Subtype	PubMed ID
esv2717424	CNV	Deletion	23290073
esv2717426	CNV	Deletion	23290073
esv1000858	CNV	Deletion	20482838
esv2717430	CNV	Deletion	23290073
esv2425384	CNV	Deletion	19546169
esv1337607	CNV	Deletion	17803354
esv2717388	CNV	Deletion	23290073
esv2717428	CNV	Deletion	23290073
esv1249335	CNV	Deletion	17803354
esv2717427	CNV	Deletion	23290073

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing MBP

DNA2.0 Custom Variant and Variant Library Synthesis for MBP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 159430 OMIM disorders: --

UniProtKB/Swiss-Prot: MBP_HUMAN, P02686

Note=The reduction in the surface charge of citrullinated and/or methylated MBP could result in a

weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as

chronical multiple sclerosis (MS), and fulminating MS (Marburg disease)

Selected diseases for MBP (see all 164): About MalaCards

munchausen by proxy autoimmune disease of the nervous system akinetic mutism juvenile pilocytic astrocytoma

optic nerve glioma chiari malformation transverse myelitis landau-kleffner syndrome

central pontine myelinolysis melanotic neuroectodermal tumor dysgammaglobulinemia pineocytoma

ossifying fibromyxoid tumor pelizaeus-merzbacher disease acid sphingomyelinase deficiency lyme disease

meningoencephalitis allergic encephalomyelitis krabbe disease myelitis

9 diseases from the University of Copenhagen DISEASES database for MBP:

Multiple sclerosis Acute disseminated encephalomyelitis Hypersensitivity reaction type II disease Brain disease

Neuropathy Measles Neuromyelitis optica Subacute sclerosing panencephalitis

Myelitis

MBP for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

Selected Novoseek inferred disease relationships for MBP gene (see all 96) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
multiple sclerosis	92.5	562	14714495 (7), 1690527 (4), 12465458 (4), 1694970 (4) (see all 99)
encephalomyelitis	89.8	187	7512579 (2), 7689596 (2), 7504090 (2), 15292513 (2) (see all 99)
demyelinating diseases	86.7	49	1384994 (2), 1718484 (1), 8632058 (1), 11234279 (1) (see all 30)
demyelination	85.6	88	19726693 (2), 7508580 (2), 12465458 (2), 7525334 (2) (see all 60)
18q- syndrome	74.4	5	8507907 (1), 9259379 (1), 8767586 (1), 14508777 (1)
autoimmune diseases	72.7	29	8393796 (1), 10377791 (1), 8590314 (1), 7692995 (1) (see all 20)
encephalomyelitis acute disseminated	70.6	2	12589368 (1), 17990580 (1)
optic neuritis	70.4	16	7510787 (2), 7515411 (2), 7513391 (1), 7524258 (1) (see all 10)
autoimmune response	69.8	29	1718484 (1), 7689820 (1), 7526591 (1), 9394837 (1) (see all 16)
myelin degeneration	63.6	5	20091409 (1), 9094982 (1), 16900293 (1), 19359623 (1) (see all 5)

Genetic Association Database (GAD): MBP
Human Genome Epidemiology (HuGE) Navigator: MBP (391 documents)

Export disorders for MBP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MBP gene, integrated from 10 sources (see all 1283):
(articles sorted by number of sources associating them with MBP)

Utopia: connect your pdf to the dynamic
world of online information

Identification of three forms of human myelin basic protein by cDNA cloning. (PubMed id 2425357)^{1, 2, 3} Kamholz J.... Lazzarini R.A. (Proc. Natl. Acad. Sci. U.S.A. 1986)
[Polymorphism of length of tetranucleotide repeat from the 5'-side from the myelin basic protein gene in multiple sclerosis in Russians]. (PubMed id 14714495)^{1, 4, 9} AndreevskiA- T.V....Favorova O.O. (Mol. Biol. (Mosk.) 2003)
Myelin basic protein gene is associated with MS in DR4- and DR5-positive Italians and Russians. (PubMed id 12939427)^{1, 4, 9} Guerini F.R....Favorova O.O. (Neurology 2003)
The isolation and characterization of four myelin basic proteins from the unbound fraction during CM52 chromatography. (PubMed id 7574672)^{1, 2, 9} Boulias C.... Moscarello M.A. (Arch. Biochem. Biophys. 1995)
Characteristic imprint of single nucleotide polymorphisms in multiple sclerosis. (PubMed id 18720029)^{1, 4, 9} Szolnoki Z....Somogyvari F. (J. Mol. Neurosci. 2009)
Pharmacogenetics of glatiramer acetate therapy for multiple sclerosis reveals drug-response markers. (PubMed id 17622942)^{1, 4, 9} Grossman I....Miller A. (Pharmacogenet. Genomics 2007)
Leukocyte gelatinase B cleavage releases encephalitogens from human myelin basic protein. (PubMed id 7685161)^{1, 2, 9} Proost P.... Opdenakker G. (Biochem. Biophys. Res. Commun. 1993)
Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)^{1, 4} Han S....Kang D. (Hum. Immunol. 2010)
Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)^{1, 4} Rajaraman P....Inskip P.D. (amp 2010)
Association between golli-MBP and schizophrenia in the Jewish Ashkenazi population: are regulatory regions involved? (PubMed id 19154657)^{1, 4} Baruch K....Navon R. (Int. J. Neuropsychopharmacol. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4155	HGNC: 6925	AceView: MBP	Ensembl:ENSG00000197971	euGenes: HUgn4155
ECgene: MBP	H-InvDB: MBP

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MBP	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Myelin_basic_protein

Intellectual Property for MBP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MBP gene:
Search GeneIP for patents involving MBP

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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HERPES
Myelinolysis Central Pontine
Measles
Meningoencephalitis
Genetic Susceptibility
Multiple Sclerosis Chronic Progressive
dysplasia
Autoimmune Diseases Nervous System
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Paraparesis Tropical Spastic
Pleocytosis
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neurodegeneration
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Myelitis Transverse
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Myelin Basic Protein

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