Aliases for MBP Gene
Aliases for MBP Gene
External Ids for MBP Gene
- HGNC: 6925
- Entrez Gene: 4155
- Ensembl: ENSG00000197971
- OMIM: 159430
- UniProtKB: P02686
Previous GeneCards Identifiers for MBP Gene
- GC18M074281
- GC18M074839
- GC18M074453
- GC18M072817
- GC18M072819
- GC18M074690
- GC18M071371
Summaries for MBP Gene
-
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]
GeneCards Summary for MBP Gene
MBP (Myelin Basic Protein) is a Protein Coding gene. Diseases associated with MBP include Demyelinating Disease and Multiple Sclerosis. Among its related pathways are Neural Crest Differentiation and Glial Cell Differentiation. Gene Ontology (GO) annotations related to this gene include protease binding and structural constituent of myelin sheath.
UniProtKB/Swiss-Prot for MBP Gene
-
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
Additional gene information for MBP Gene
- Monarch Initiative
- Search for MBP at DataMed
- Search for MBP at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBP Gene
Genomics for MBP Gene
GeneHancer (GH) Regulatory Elements for MBP Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH18I077122 | Promoter/Enhancer | 2.5 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 556.5 | +4.9 | 4912 | 12 | PKNOX1 FOXA2 ZFP64 ARID4B FEZF1 IRF4 ZNF48 YY1 ZNF121 GLIS2 | MBP ENSG00000278330 GC18M077130 | |
GH18I077018 | Promoter/Enhancer | 0.7 | EPDnew dbSUPER | 550.1 | +116.6 | 116633 | 0.1 | MBP GC18M077011 GC18M077009 ENSG00000275178 | ||
GH18I077134 | Enhancer | 0.4 | ENCODE dbSUPER | 550.8 | -1.1 | -1120 | 0 | MBP ENSG00000265844 GC18M077130 | ||
GH18I077051 | Enhancer | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 33.6 | +78.5 | 78503 | 7.6 | HDGF FOXA2 MLX ARNT ARID4B YBX1 ZNF2 IRF4 ZNF143 JUNB | MBP ZNF236 ENSG00000275178 GC18M077011 GC18M077009 | |
GH18I077059 | Enhancer | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 27.6 | +66.2 | 66185 | 15.8 | HDGF PKNOX1 SIN3A IRF4 BRCA1 ZNF143 ATF7 FOS RUNX3 JUNB | MBP ENSG00000275178 GC18M077009 GC18M077011 |
- Top Transcription factor binding sites by QIAGEN in the MBP gene promoter:
Regulatory Element Products
Genomic Locations for MBP Gene
- chr18:76,978,827-77,133,708
- (GRCh38/hg38)
- Size:
- 154,882 bases
- Orientation:
- Minus strand
- chr18:74,690,783-74,845,639
- (GRCh37/hg19)
Genomic View for MBP Gene
- Cytogenetic band:
-
- 18q23 by Ensembl
- 18q23 by Entrez Gene
- 18q23 by HGNC


RefSeq DNA sequence for MBP Gene
Proteins for MBP Gene
-
Protein details for MBP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P02686-MBP_HUMAN
- Recommended name:
- Myelin basic protein
- Protein Accession:
- P02686
- A4FU54
- A6NI84
- A8MY86
- A8MYL4
- B3KY66
- B7ZKS2
- B7ZKS4
- Q15337
- Q15338
- Q15339
- Q15340
- Q59GX3
- Q65ZS4
- Q6AI64
- Q6FH37
- Q6FI04
- Q6PK23
Protein attributes for MBP Gene
- Size:
- 304 amino acids
- Molecular mass:
- 33117 Da
- Quaternary structure:
-
- Homodimer. Isoform 3 exists as a homodimer.
- SequenceCaution:
-
- Sequence=AAC41944.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The C-terminus contains a Histidine tag.; Evidence={ECO:0000305}; Sequence=BAD92223.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH10359.1; Type=Miscellaneous discrepancy; Note=wrong intron-exon boundaries.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for MBP Gene
Protein Expression for MBP Gene
Post-translational modifications for MBP Gene
- Arg-241 was found to be 6% monomethylated and 60% symmetrically dimethylated.
- Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1.
- Several charge isomers of MBP; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4, C5, C6, C7, C8-A and C8-B (the least cationic form); are produced as a result of optional PTM, such as phosphorylation, deamidation of glutamine or asparagine, arginine citrullination and methylation. C8-A and C8-B contain each two mass isoforms termed C8-A(H), C8-A(L), C8-B(H) and C8-B(L), (H) standing for higher and (L) for lower molecular weight. C3, C4 and C5 are phosphorylated. The ratio of methylated arginine residues decreases during aging, making the protein more cationic.
- The N-terminal alanine is acetylated (isoform 3, isoform 4, isoform 5 and isoform 6).
Other Protein References for MBP Gene
- ENSEMBL proteins:
-
- ENSP00000346545
- ENSP00000348273
- ENSP00000352667
- ENSP00000380958
- ENSP00000380961
- ENSP00000380963
- ENSP00000380964
- ENSP00000380967
- ENSP00000380973
- ENSP00000405882
- ENSP00000431267
- ENSP00000431335
- ENSP00000432988
- ENSP00000434011
- ENSP00000435243
- ENSP00000435322
- ENSP00000435641
- ENSP00000436830
- ENSP00000436951
- ENSP00000437063
- ENSP00000442393
- ENSP00000462223
- ENSP00000462374
- ENSP00000462734
- ENSP00000462758
- ENSP00000462780
- ENSP00000463137
- ENSP00000463164
- ENSP00000463403
- ENSP00000463780
- ENSP00000372025
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for MBP (MBP)
- Cell Signaling Technology (CST) Antibodies for MBP (MBP)
- Novus Biologicals Antibodies for MBP
-
Abcam antibodies for MBP
-
Cloud-Clone Corp. Antibodies for MBP
- Invitrogen Antibodies for MBP
- antibodies-online: Search results for 186 available MBP Antibodies ranked by validation data
- Compare Top MBP Antibodies
-
Quality Products:
- ABIN462005
- ABIN1078364
- ABIN871740
- ABIN1574105
- ABIN119025
- ABIN119024
- ABIN181840
- ABIN110680
- ABIN358484
- ABIN119023
- ABIN462005
- ABIN1078364
- ABIN871740
- ABIN1574105
- ABIN119025
- ABIN119024
- ABIN181840
- ABIN110680
- ABIN358484
- ABIN119023
- ABIN462005
- ABIN1078364
- ABIN871740
- ABIN1574105
- ABIN119025
- ABIN119024
- ABIN181840
- ABIN110680
- ABIN358484
- ABIN119023
- GeneTex MBP antibody for MBP
-
Santa Cruz Biotechnology (SCBT) Antibodies for MBP
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for MBP
- Origene Custom Protein Services for MBP
- ProSpec Recombinant Proteins for MBP
-
Cloud-Clone Corp. Proteins for MBP
- antibodies-online: Search results for 28 available MBP Proteins ranked by validation data
- Compare Top MBP Proteins
-
Quality Products:
- ABIN1473175
- ABIN1461865
- ABIN1614038
- ABIN1608858
- ABIN1614574
- ABIN1608779
- ABIN2125979
- ABIN2726640
- ABIN2123324
- ABIN1047418
- ABIN1473175
- ABIN1461865
- ABIN1614038
- ABIN1608858
- ABIN1614574
- ABIN1608779
- ABIN2125979
- ABIN2726640
- ABIN2123324
- ABIN1047418
- ABIN1473175
- ABIN1461865
- ABIN1614038
- ABIN1608858
- ABIN1614574
- ABIN1608779
- ABIN2125979
- ABIN2726640
- ABIN2123324
- ABIN1047418
- Search GeneTex for Proteins for MBP
-
Abcam proteins for MBP
Assay Products
- R&D Systems ELISAs and other biochemical assays for MBP (MBP)
- antibodies-online: Search results for 54 available MBP Elisa Kits ranked by validation data
- Compare Top MBP Elisa Kits
-
Quality Products:
- ABIN366558
- ABIN367838
- ABIN1571156
- ABIN368451
- ABIN2851344
- ABIN628798
- ABIN1564404
- ABIN1564405
- ABIN994011
- ABIN1056323
- ABIN366558
- ABIN367838
- ABIN1571156
- ABIN368451
- ABIN2851344
- ABIN628798
- ABIN1564404
- ABIN1564405
- ABIN994011
- ABIN1056323
- ABIN366558
- ABIN367838
- ABIN1571156
- ABIN368451
- ABIN2851344
- ABIN628798
- ABIN1564404
- ABIN1564405
- ABIN994011
- ABIN1056323
No data available for DME Specific Peptides for MBP Gene
Domains & Families for MBP Gene
Gene Families for MBP Gene
- Human Protein Atlas (HPA):
-
- Candidate cardiovascular disease genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for MBP Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MBP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P02686- Family:
-
- Belongs to the myelin basic protein family.
Function for MBP Gene
Molecular function for MBP Gene
- GENATLAS Biochemistry:
- myelin,basic protein,major component of normal myelin of central nervous system,with three alternatively spliced isoforms
- UniProtKB/Swiss-Prot Function:
- The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
Phenotypes From GWAS Catalog for MBP Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002020 | protease binding | IEA | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0005516 | calmodulin binding | IPI | 19855925 |
GO:0019911 | structural constituent of myelin sheath | IBA | -- |
Phenotypes for MBP Gene
- MGI mutant phenotypes for MBP:
-
inferred from 6 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- hematopoietic system phenotype
- GenomeRNAi human phenotypes for MBP:
-
- Increased viability
- Increased gamma-H2AX phosphorylation
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased IL-8 secretion
- Weakly decreased NFAT1-GFP nuclear translocation
- Negative genetic interaction between BLM-/- and BLM+/+
Animal Models for MBP Gene
- MGI Knock Outs for MBP:
-
- Mbp tm1Atc
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MBP
-
- Search ViGene Biosciences for MBP
CRISPR Products
-
OriGene CRISPR knockouts for MBP
- genomics-online: gRNA clones - Search results for 213 available MBP gene related products
- Overview of 213 available MBP gene related products
- Applied Biological Materials CRISPR for MBP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MBP
- GenScript: Design CRISPR guide RNA sequences for MBP
miRNA for MBP Gene
- miRTarBase miRNAs that target MBP
miRNA Products
- Search ViGene Biosciences for MBP
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MBP
- Browse OriGene Inhibitory RNA Products For MBP
- genomics-online: shRNA clones - Search results for 213 available MBP gene related products
- Overview of 213 available MBP gene related products
Clone Products
-
OriGene ORF clones in human for MBP
- RG223405
- RC223405L2
- RC223405L1
- RC223405
- RG221469
- RC221469L2
- RC221469L1
- RC221469
- RG209071
- RC209071L2
- RC209071L1
- RC209071
- RG210291
- RC210291L2
- RC210291L1
- RC210291
- RG200710
- RC200710L2
- RC200710L1
- RC200710
- RG215746
- RC215746L2
- RC215746L1
- RC215746
- RC223405L2V
- RC223405L1V
- RC221469L2V
- RC221469L1V
- RC209071L2V
- RC209071L1V
- RC210291L2V
- RC210291L1V
- RC200710L2V
- RC200710L1V
- RC215746L2V
- RC215746L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MBP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MBP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MBP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MBP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MBP
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MBP Gene
Localization for MBP Gene
Subcellular locations from UniProtKB/Swiss-Prot for MBP Gene
- Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.
- Isoform 3: Nucleus. Note=Targeted to nucleus in oligodendrocytes.
- Plasma membrane (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005622 | intracellular | IDA | 22524708 |
GO:0005634 | nucleus | IEA | -- |
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0033269 | internode region of axon | IBA | -- |
Pathways & Interactions for MBP Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Neuroscience | ||
2 | Glial Cell Differentiation | ||
3 | G-protein signaling Ras family GTPases in kinase cascades (scheme) |
.44
|
|
4 | MECP2 and Associated Rett Syndrome | ||
5 | Neural Crest Differentiation |
Pathways by source for MBP Gene
1 Cell Signaling Technology pathway for MBP Gene
6 BioSystems pathways for MBP Gene
Interacting Proteins for MBP Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | IDA | 22524708 |
GO:0006955 | immune response | TAS | 7504278 |
GO:0007268 | chemical synaptic transmission | TAS | 2434243 |
GO:0007417 | central nervous system development | TAS | 2434243 |
GO:0007605 | sensory perception of sound | IEA | -- |
Drugs & Compounds for MBP Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Myelin Basic Protein (68-82), guinea pig | Pharma | 0 | ||||
Myelin Basic Protein (87-99) | Pharma | Encephalitogenic peptide | 0 | |||
ATX-MS-1467 | Pharma | 0 | ||||
MOG (35-55) | Pharma | Minor component of CNS myelin, Encephalitogenic myelin oligodendrocyte glycoprotein fragment | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
3-O-Sulfogalactosylceramide (d18:1/24:0) |
|
151122-71-3 | ||||
Nogo-66 (1-40) |
|
475221-20-6 |
|
|
||
PLP (139-151) |
|
122018-58-0 |
|
|
(5) Tocris Compounds for MBP Gene
Compound | Action | Cas Number |
---|---|---|
B2 | Promotes inclusion formation in Huntington's and Parkinson's diseases | 115687-05-3 |
MOG (35-55) | Encephalitogenic myelin oligodendrocyte glycoprotein fragment | 149635-73-4 |
Nogo-66 (1-40) | Competitive antagonist for Nogo-66 receptor; promotes neuron regeneration | 475221-20-6 |
PLP (139-151) | Encephalitogenic myelin proteolipid fragment | 122018-58-0 |
TCS PrP Inhibitor 13 | Antiprion agent; potently inhibits PrP-res accumulation | 34320-83-7 |
(2) ApexBio Compounds for MBP Gene
Compound | Action | Cas Number |
---|---|---|
Myelin Basic Protein (68-82), guinea pig | 98474-59-0 | |
Myelin Basic Protein (87-99) | Encephalitogenic peptide | 118506-26-6 |
Transcripts for MBP Gene
mRNA/cDNA for MBP Gene
- (12) REFSEQ mRNAs :
- (34) Additional mRNA sequences :
- (1185) Selected AceView cDNA sequences:
- (48) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MBP Gene
- Myelin basic protein:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MBP
- genomics-online: gRNA clones - Search results for 213 available MBP gene related products
- Overview of 213 available MBP gene related products
- Applied Biological Materials CRISPR for MBP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MBP
- GenScript: Design CRISPR guide RNA sequences for MBP
miRNA Products
- Search ViGene Biosciences for MBP
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MBP
- Browse OriGene Inhibitory RNA Products For MBP
- genomics-online: shRNA clones - Search results for 213 available MBP gene related products
- Overview of 213 available MBP gene related products
Clone Products
-
OriGene ORF clones in human for MBP
- RG223405
- RC223405L2
- RC223405L1
- RC223405
- RG221469
- RC221469L2
- RC221469L1
- RC221469
- RG209071
- RC209071L2
- RC209071L1
- RC209071
- RG210291
- RC210291L2
- RC210291L1
- RC210291
- RG200710
- RC200710L2
- RC200710L1
- RC200710
- RG215746
- RC215746L2
- RC215746L1
- RC215746
- RC223405L2V
- RC223405L1V
- RC221469L2V
- RC221469L1V
- RC209071L2V
- RC209071L1V
- RC210291L2V
- RC210291L1V
- RC200710L2V
- RC200710L1V
- RC215746L2V
- RC215746L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MBP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MBP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MBP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MBP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP15: | - |
ExUns: | 14c | · | 14d | ^ | 15a | · | 15b |
---|---|---|---|---|---|---|---|
SP1: | |||||||
SP2: | |||||||
SP3: | |||||||
SP4: | |||||||
SP5: | |||||||
SP6: | |||||||
SP7: | |||||||
SP8: | |||||||
SP9: | |||||||
SP10: | - | - | |||||
SP11: | |||||||
SP12: | |||||||
SP13: | |||||||
SP14: | |||||||
SP15: |
Expression for MBP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Oligodendrocyte Precursor Cells Forebrain White Matter
- Adult Endothelial Cells Blood Brain Barrier
- Hypothalamus
- Thalamus
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Myelinating Schwann Cells Peripheral Nerve Domain
- Myelinating Oligodendrocyte Cells Spinal Cord White Matter
- Oligodendrocyte-like cells (Wang S et. al. 2013)
- B27-induced oligodendrocyte-like cells(Sundberg M et. al. 2010)
- Spinal Cord (Nervous System)
-
Peripheral Nervous System (Nervous System)
- Immature Schwann Cells Peripheral Nerve Domain
- Myelinating Schwann Cells Peripheral Nerve Domain
- Schwann-like cells(McKenzie IA et. al. 2006)
- Schwann-like cells(Pomp O et. al. 2008)
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- T Helper Cells Thymus
- Eosinophil Progenitors Hematopoietic Bone Marrow
- Bone (Muscoskeletal System)
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
- Gonad
- Kidney (Urinary System)
- Inner Cell Mass (Early Embryonic Tissues)
-
Ovary (Reproductive System)
- Cumulus Cells Antral Follicle
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
-
Liver (Hepatobiliary System)
- Mature Mesothelial Cells Liver Lobule
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Endothelium (Cardiovascular System)
- Adult Endothelial Cells Blood Brain Barrier
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Neural Tube (Nervous System)
- Heart (Cardiovascular System)
- NULL (Uncategorized)
- Germ Cells (Reproductive System)
- Oligodendrocytes (Nervous System)
mRNA differential expression in normal tissues according to GTEx for MBP Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MBP Gene
NURSA nuclear receptor signaling pathways regulating expression of MBP Gene:
MBPSOURCE GeneReport for Unigene cluster for MBP Gene:
Hs.551713mRNA Expression by UniProt/SwissProt for MBP Gene:
P02686-MBP_HUMANEvidence on tissue expression from TISSUES for MBP Gene
- Kidney(5)
- Nervous system(5)
- Skin(4.9)
- Lung(4.5)
- Eye(3.5)
- Blood(3.3)
- Spleen(2.9)
- Lymph node(2.8)
- Muscle(2.8)
- Thyroid gland(2.4)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs for MBP
-
OriGene qPCR primer pairs and template standards for MBP
- genomics-online: primer clones - Search results for 213 available MBP gene related products
- Overview of 213 available MBP gene related products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MBP Gene
Orthologs for MBP Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | MBP 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Mbp 33 16 34 |
|
||
dog (Canis familiaris) |
Mammalia | MBP 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | MBP 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | MBP 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | MBP 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | MBP 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | MBP 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | mbp 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.25724 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | mbpb 34 33 |
|
OneToOne |
- Species where no ortholog for MBP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MBP Gene
No data available for Paralogs for MBP Gene
Variants for MBP Gene
SNP ID | Clin | Chr 18 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000001600 | -- | 77,073,734(-) | T/G | genic_upstream_transcript_variant, intron_variant | |
rs1000003982 | -- | 77,068,016(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
rs1000010918 | -- | 77,035,319(-) | G/A | genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant | |
rs1000041881 | -- | 76,993,584(-) | T/G | genic_downstream_transcript_variant, intron_variant | |
rs1000061231 | -- | 77,068,203(-) | G/C | genic_upstream_transcript_variant, intron_variant |
Additional Variant Information for MBP Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MBP Gene
Disorders for MBP Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
demyelinating disease |
|
|
multiple sclerosis |
|
|
central pontine myelinolysis |
|
|
acute disseminated encephalomyelitis |
|
|
secondary progressive multiple sclerosis |
|
UniProtKB/Swiss-Prot
MBP_HUMAN- Note=The reduction in the surface charge of citrullinated and/or methylated MBP could result in a weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as chronical multiple sclerosis (MS), and fulminating MS (Marburg disease).
Additional Disease Information for MBP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for MBP Gene
Publications for MBP Gene
- Pharmacogenetics of glatiramer acetate therapy for multiple sclerosis reveals drug-response markers. (PMID: 17622942) Grossman I … Miller A (Pharmacogenetics and genomics 2007) 3 22 44 58
- Myelin basic protein gene is associated with MS in DR4- and DR5-positive Italians and Russians. (PMID: 12939427) Guerini FR … Favorova OO (Neurology 2003) 3 22 44 58
- The isolation and characterization of four myelin basic proteins from the unbound fraction during CM52 chromatography. (PMID: 7574672) Boulias C … Moscarello MA (Archives of biochemistry and biophysics 1995) 3 4 22 58
- Identification of three forms of human myelin basic protein by cDNA cloning. (PMID: 2425357) Kamholz J … Lazzarini R (Proceedings of the National Academy of Sciences of the United States of America 1986) 2 3 4 58
- Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
Products for MBP Gene
- R&D Systems Antibodies for MBP (MBP)
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- R&D Systems ELISAs and other biochemical assays for MBP (MBP)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
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- Custom Assay Services
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- OriGene qPCR primer pairs for MBP
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- RC215746L1V
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- RC210291L1
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- RC209071L1
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- RC221469
- RC221469L1
- RC221469L2
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- RC223405
- RC223405L1
- RC223405L2
- RG223405
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Cell Signaling Technology (CST) Antibodies for MBP (MBP)
- Search for Antibodies & Assays
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- Browse Sino Biological Cell Lysates
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for MBP
- Novus Biologicals proteins and lysates for MBP
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for MBP
- Abcam proteins for MBP
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for MBP
- Cloud-Clone Corp. Antibodies for MBP
- Cloud-Clone Corp. Proteins for MBP
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for MBP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for MBP
- Cyagen custom Knockout/knockin (KOKI) mouse models for MBP
- VectorBuilder custom plasmid, inducible vectors for MBP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MBP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 186 available MBP Antibodies ranked by validation data
- Compare Top MBP Antibodies
- Quality Products:
- ABIN119023
- ABIN358484
- ABIN110680
- ABIN181840
- ABIN119024
- ABIN119025
- ABIN1574105
- ABIN871740
- ABIN1078364
- ABIN462005
- ABIN119023
- ABIN358484
- ABIN110680
- ABIN181840
- ABIN119024
- ABIN119025
- ABIN1574105
- ABIN871740
- ABIN1078364
- ABIN462005
- ABIN119023
- ABIN358484
- ABIN110680
- ABIN181840
- ABIN119024
- ABIN119025
- ABIN1574105
- ABIN871740
- ABIN1078364
- ABIN462005
- antibodies-online: Search results for 54 available MBP Elisa Kits ranked by validation data
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- ABIN366558
- ABIN367838
- ABIN1571156
- ABIN368451
- ABIN2851344
- ABIN628798
- ABIN1564404
- ABIN1564405
- ABIN994011
- ABIN1056323
- ABIN366558
- ABIN367838
- ABIN1571156
- ABIN368451
- ABIN2851344
- ABIN628798
- ABIN1564404
- ABIN1564405
- ABIN994011
- ABIN1056323
- ABIN366558
- ABIN367838
- ABIN1571156
- ABIN368451
- ABIN2851344
- ABIN628798
- ABIN1564404
- ABIN1564405
- ABIN994011
- ABIN1056323
- antibodies-online: Search results for 28 available MBP Proteins ranked by validation data
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- ABIN1047418
- ABIN2123324
- ABIN2726640
- ABIN2125979
- ABIN1608779
- ABIN1614574
- ABIN1608858
- ABIN1614038
- ABIN1461865
- ABIN1473175
- ABIN1047418
- ABIN2123324
- ABIN2726640
- ABIN2125979
- ABIN1608779
- ABIN1614574
- ABIN1608858
- ABIN1614038
- ABIN1461865
- ABIN1473175
- ABIN1047418
- ABIN2123324
- ABIN2726640
- ABIN2125979
- ABIN1608779
- ABIN1614574
- ABIN1608858