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MBP Gene

protein-coding   GIFtS: 65
GCID: GC18M074690

Myelin Basic Protein

  See MBP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Myelin Basic Protein1 2
Myelin A1 Protein2 3
Myelin Membrane Encephalitogenic Protein2 3

External Ids:    HGNC: 69251   Entrez Gene: 41552   Ensembl: ENSG000001979717   OMIM: 1594305   UniProtKB: P026863   
ORGUL members:         

Export aliases for MBP gene to outside databases

Previous GC identifers: GC18M074281 GC18M074839 GC18M074453 GC18M072817 GC18M072819 GC18M071371


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MBP Gene:
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and
Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the
immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional
exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription
start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons
unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal
Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce
the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting
that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is
important for the function and/or regulation of these genes. (provided by RefSeq, Jul 2008)

GeneCards Summary for MBP Gene:
MBP (myelin basic protein) is a protein-coding gene. Diseases associated with MBP include akinetic mutism, and chiari malformation. GO annotations related to this gene include protease binding and structural constituent of myelin sheath.

UniProtKB/Swiss-Prot: MBP_HUMAN, P02686
Function: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein
components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The
smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The
non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early
developing brain long before myelination, maybe as components of transcriptional complexes, and may also be
involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional
post-translational modifications give a wide spectrum of isomers, with each of them potentially having a
specialized function. Induces T-cell proliferation

Gene Wiki entry for MBP (Myelin basic protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MBP gene promoter:
         PPAR-alpha   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MBP promoter sequence
   Search Chromatin IP Primers for MBP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q23   Ensembl cytogenetic band:  18q23   HGNC cytogenetic band: 18q23

MBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MBP gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M074690:  view genomic region     (about GC identifiers)

Start:
74,690,783 bp from pter      End:
74,845,639 bp from pter
Size:
154,857 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MBP_HUMAN, P02686 (See protein sequence)
Recommended Name: Myelin basic protein  
Size: 304 amino acids; 33117 Da
Subunit: Homodimer. Isoform 3 exists as a homodimer
Developmental stage: Expression begins abruptly in 14-16 week old fetuses. Even smaller isoforms seem to be
produced during embryogenesis; some of these persisting in the adult. Isoform 4 expression is more evident at 16
weeks and its relative proportion declines thereafter
Sequence caution: Sequence=AAC41944.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The C-terminus
contains a Histidine tag; Sequence=BAD92223.1; Type=Erroneous initiation; Note=Translation N-terminally
shortened; Sequence=CAH10359.1; Type=Miscellaneous discrepancy; Note=wrong intron-exon boundaries;
6 PDB 3D structures from and Proteopedia for MBP:
1BX2 (3D)        1FV1 (3D)        1HQR (3D)        1QCL (3D)        1YMM (3D)        1ZGL (3D)    
Secondary accessions: A4FU54 A6NI84 A8MY86 A8MYL4 B3KY66 B7ZKS2 B7ZKS4 Q15337 Q15338 Q15339
Q15340 Q59GX3 Q65ZS4 Q6AI64 Q6FH37 Q6FI04 Q6PK23
Alternative splicing: 6 isoforms:  P02686-1   P02686-2   P02686-3   P02686-4   P02686-5   P02686-6   (Initiator Met-1 is removed. Contains a N-acetylalanine at position 2)

Explore the universe of human proteins at neXtProt for MBP: NX_P02686

Explore proteomics data for MBP at MOPED

Post-translational modifications: 

  • Several charge isomers of MBP; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4, C5, C6,
    C7, C8-A and C8-B (the least cationic form); are produced as a result of optional PTM, such as phosphorylation,
    deamidation of glutamine or asparagine, arginine citrullination and methylation. C8-A and C8-B contain each two
    mass isoforms termed C8-A(H), C8-A(L), C8-B(H) and C8-B(L), (H) standing for higher and (L) for lower molecular
    weight. C3, C4 and C5 are phosphorylated. The ratio of methylated arginine residues decreases during aging,
    making the protein more cationic1
  • The N-terminal alanine is acetylated (isoform 3, isoform 4, isoform 5 and isoform 6)1
  • Arg-241 was found to be 6% monomethylated and 60% symmetrically dimethylated1
  • Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK11
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MBP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001020252.1  NP_001020261.1  NP_001020263.1  NP_001020271.1  NP_001020272.1  NP_002376.1  

    ENSEMBL proteins: 
     ENSP00000372025   ENSP00000462734   ENSP00000380973   ENSP00000380964   ENSP00000380963  
     ENSP00000435243   ENSP00000352667   ENSP00000436830   ENSP00000462780   ENSP00000431267  
     ENSP00000380967   ENSP00000346545   ENSP00000431335   ENSP00000462758   ENSP00000434011  
     ENSP00000435641   ENSP00000462223   ENSP00000463780   ENSP00000463403   ENSP00000405882  
     ENSP00000432988   ENSP00000442393   ENSP00000436951   ENSP00000463137   ENSP00000435322  
     ENSP00000437063   ENSP00000380961   ENSP00000380958   ENSP00000462374   ENSP00000463164  
     ENSP00000348273  

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    Cloud-Clone Corp. Proteins for MBP

     
    Search eBioscience for Proteins for MBP 

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    MBP Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MBP
    Cloud-Clone Corp. CLIAs for MBP
    Search eBioscience for ELISAs for MBP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000548 Myelin_BP

    Graphical View of Domain Structure for InterPro Entry P02686

    ProtoNet protein and cluster: P02686

    1 Blocks protein domain: IPB000548 Myelin basic protein

    UniProtKB/Swiss-Prot: MBP_HUMAN, P02686
    Similarity: Belongs to the myelin basic protein family


    Find genes that share domains with MBP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MBP_HUMAN, P02686
    Function: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein
    components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The
    smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The
    non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early
    developing brain long before myelination, maybe as components of transcriptional complexes, and may also be
    involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional
    post-translational modifications give a wide spectrum of isomers, with each of them potentially having a
    specialized function. Induces T-cell proliferation

         Genatlas biochemistry entry for MBP:
    myelin,basic protein,major component of normal myelin of central nervous system,with three alternatively spliced
    isoforms

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IEA--
    GO:0005515protein binding IPI17064692
    GO:0019911structural constituent of myelin sheath IEA--
         
    Find genes that share ontologies with MBP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MBP:
     Increased gamma-H2AX phosphory 

         11 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Mbp):
     behavior/neurological  cellular  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  nervous system  normal  reproductive system 
     vision/eye 

    Find genes that share phenotypes with MBP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mbptm1Atc for MBP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MBP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MBP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MBP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MBP

    miRNA
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    Block miRNA regulation of human, mouse, rat MBP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MBP (see all 22):
    hsa-miR-2052 hsa-miR-34b* hsa-miR-16-2* hsa-miR-1258 hsa-miR-3653 hsa-miR-132 hsa-miR-449a hsa-miR-1323
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MBP

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: MBP (NM_001633)
    Sino Biological Human cDNA Clone for MBP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MBP

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    eBioscience FlowRNA Probe Sets ( VA4-12730) for MBP 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MBP_HUMAN, P02686: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of
    myelin
    MBP_HUMAN, P02686: Isoform 3: Nucleus. Note=Targeted to nucleus in oligodendrocytes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    plasma membrane3
    cytosol2
    extracellular2
    nucleus2
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane IEA--
    GO:0033269internode region of axon IEA--
    GO:0042995cell projection ----
    GO:0043025neuronal cell body IEA--

    Find genes that share ontologies with MBP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MBP About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1G protein signaling Ras family GTPases in kinase cascades scheme
    MAPK Cascade0.44
    2Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    3Spinal Cord Injury
    Spinal Cord Injury
    4Selected targets of C EBPbeta
    Selected targets of C EBPbeta
    5Neural Crest Differentiation
    Neural Crest Differentiation


    4 BioSystems Pathways for MBP
        Spinal Cord Injury
    Neural Crest Differentiation
    MAPK Cascade
    Glial Cell Differentiation



        Pathway & Disease-focused RT2 Profiler PCR Arrays including MBP: 
              Terminal Differentiation Markers in human mouse rat
              Multiple Sclerosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MBP (P026861, 2, 3 ENSP000003482734) via UniProtKB, MINT, STRING, and/or I2D (see all 90)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APTXQ7Z2E32, 3, ENSP000004008064MINT-2860724 I2D: score=3 STRING: ENSP00000400806
    ATN1P542592, 3, ENSP000003490764MINT-2860743 I2D: score=3 STRING: ENSP00000349076
    MAPK1P284822, 3, ENSP000002158324MINT-4301912 I2D: score=1 STRING: ENSP00000215832
    ENSG00000206308P019033, ENSP000003727464I2D: score=2 STRING: ENSP00000372746
    HLA-DRAP019033, ENSP000003787864I2D: score=2 STRING: ENSP00000378786
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS7504278
    GO:0007268synaptic transmission TAS2434243
    GO:0007417central nervous system development TAS2434243
    GO:0008366axon ensheathment TAS2434243
    GO:0009636response to toxic substance IEA--

    Find genes that share ontologies with MBP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for MBP
      Browse compounds at ApexBio 

    Compounds for MBP available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PLP (139-151)Encephalitogenic myelin proteolipid fragment[122018-58-0]
    ONO 2506Inhibits S100B synthesis; neuroprotective[185517-21-9]
    C3bot (154-182)Neurotrophic fragment of clostridial C3 protein[1246280-79-4]
    MOG (35-55)Encephalitogenic myelin oligodendrocyte glycoprotein fragment[149635-73-4]
    Nogo-66 (1-40)Competitive antagonist for Nogo-66 receptor; promotes neuron regeneration[475221-20-6]

    1 HMDB Compound for MBP    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-32480186

    Selected Novoseek inferred chemical compound relationships for MBP gene (see all 101)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',3'-cyclic nucleotide 87.3 59 11279272 (2), 11356257 (2), 1964183 (1), 8416742 (1) (see all 39)
    glatiramer acetate 78.9 106 9237101 (7), 7541725 (5), 10861011 (4), 8965119 (3) (see all 28)
    copolymer i 69.6 9 1707304 (3), 1714060 (1), 11003134 (1)
    cuprizone 62.8 5 18938062 (1), 20305752 (1), 17290413 (1)
    threonine 59.4 24 1315774 (1), 14594813 (1), 1716348 (1), 1716457 (1) (see all 20)
    benzophenone-3 55.6 9 7679413 (1), 16049372 (1), 7517457 (1), 11207660 (1) (see all 7)
    sulfatide 55.4 22 18039685 (3), 9482258 (2), 1372178 (2), 12161033 (1) (see all 10)
    sulf 54.4 12 9130259 (4), 1372178 (3), 12161033 (1)
    citrulline 53.2 36 1707596 (2), 7683860 (2), 7507225 (2), 10675299 (2) (see all 15)
    edss 50.1 3 9619641 (1), 9987755 (1)



    Find genes that share compounds with MBP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MBP gene (8 alternative transcripts): 
    NM_001025081.1  NM_001025090.1  NM_001025092.1  NM_001025100.1  NM_001025101.1  NM_002385.2  NM_001025094.1  NM_001025098.1  

    Unigene Cluster for MBP:

    Myelin basic protein
    Hs.551713  [show with all ESTs]
    Unigene Representative Sequence: NM_001025100
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 48):
    ENST00000382582 ENST00000490319(uc010dqz.3) ENST00000585201(uc010xfe.1)
    ENST00000397875 ENST00000397866 ENST00000397865 ENST00000527041 ENST00000359645
    ENST00000528160 ENST00000577755 ENST00000527975 ENST00000578715 ENST00000397869
    ENST00000354542 ENST00000531144 ENST00000583474 ENST00000533278 ENST00000526111

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    Selected qRT-PCR Assays for microRNAs that regulate MBP (see all 22):
    hsa-miR-2052 hsa-miR-34b* hsa-miR-16-2* hsa-miR-1258 hsa-miR-3653 hsa-miR-132 hsa-miR-449a hsa-miR-1323
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    Primer
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    eBioscience FlowRNA Probe Sets ( VA4-12730) for MBP 

    Additional mRNA sequence: 

    AB208986.1 AK074315.1 AK093588.1 AK094611.1 AK095121.1 AK098402.1 AK098513.1 AK122594.1 
    AK123433.1 AK124830.1 AK126977.1 AK128770.1 AK128788.1 AK289893.1 AK293922.1 AK296492.1 
    AK314553.1 BC008749.2 BC030093.1 BC065248.1 BC068550.1 BC080654.1 BC101771.1 BC101773.1 
    BC130034.1 BC143348.1 BC143350.1 CR536534.1 CR541919.1 L18865.1 M13577.1 M30047.1 
    M30515.1 M30516.1 

    Selected DOTS entries (see all 159):

    DT.100889742  DT.101985667  DT.95223942  DT.95095286  DT.91848616  DT.95095349  DT.121101020  DT.121100766 
    DT.95310721  DT.100889773  DT.121100675  DT.100889749  DT.95211483  DT.121101087  DT.100889740  DT.91873487 
    DT.86855495  DT.121100576  DT.95164195  DT.100889757  DT.111002  DT.100889751  DT.100889768  DT.121100982 

    Selected AceView cDNA sequences (see all 1185):

    BE677395 BM931305 AK124830 CB154972 H44561 AA348748 CD514400 AA321162 
    AA332866 BU151039 AW118326 BQ058155 CB152985 AA434553 CB153096 AI379430 
    CB152227 CF455220 BX953029 F01798 CD514255 BF056430 AI866444 AW206642 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MBP (see all 15)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ·
    SP1:                                                                          -           -                 -                 -     -                           
    SP2:                                                                          -     -     -                 -                 -     -                           
    SP3:                                                                          -           -                 -           -     -     -                           
    SP4:                                                                          -     -     -                 -           -     -     -                           
    SP5:                                                                    -     -     -     -     -     -     -     -     -     -     -     -                     

    ExUns: 14c · 14d ^ 15a · 15b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for MBP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTATTAATA
    MBP Expression
    About this image


    MBP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Thalamus
             Oligodendrocyte-like cells
     
     Spinal Cord (Nervous System)    fully expand to see all 6 entries
             Myelinating Oligodendrocyte Cells Spinal Cord White Matter
             Oligodendrocyte-like cells
     
     Oligodendrocytes (Nervous System)    fully expand to see all 5 entries
             Oligodendrocyte-like cells
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 4 entries
             Myelinating Schwann Cells Peripheral Nerve Domain
             Schwann-like cells
     
     Schwann Cells (Nervous System)    fully expand to see all 2 entries
             Schwann-like cells
    MBP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MBP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.551713

    UniProtKB/Swiss-Prot: MBP_HUMAN, P02686
    Tissue specificity: MBP isoforms are found in both the central and the peripheral nervous system, whereas
    Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from
    the immune system

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MBP: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for MBP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mbp1 , 5 myelin basic protein1, 5 88.35(n)1
    87.55(a)1
      18 (55.84 cM)5
    171961  NM_010777.31  NP_034907.11 
     824751465 
    chicken
    (Gallus gallus)
    Aves MBP1 myelin basic protein 71.66(n)
    73.65(a)
      396217  NM_205280.1  NP_990611.1 
    lizard
    (Anolis carolinensis)
    Reptilia MBP6
    myelin basic protein
    42(a)
    1 ↔ 1
    4(50865105-50973289)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.257242 Xenopus laevis mRNA for myelin basic protein, complete more 77.52(n)    AB000736.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mbpb1 myelin basic protein b 61.48(n)
    54.92(a)
      368319  NM_001271459.1  NP_001258388.1 


    ENSEMBL Gene Tree for MBP (if available)
    TreeFam Gene Tree for MBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MBP (see all 4034)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1148446341,2
    F--71411579(+) CCTGTG/AAGTGT 4 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1400077731,2
    --71411649(+) AGTAGA/GGTGGG 4 -- us2k10--------
    rs600904461,2
    C--74683074(+) ACCCT-/GTCTGTG 2 -- int11Minor allele frequency- GT:0.00NA 2
    rs4703191,2
    C,F,A--74690322(+) TAAGAT/GCCTGT 5 -- ds50018Minor allele frequency- G:0.21NA WA EA 368
    rs351901261,2
    C--74690349(+) AAAAC-/AAAAGAG 5 -- ds50010--------
    rs1868538441,2
    --74690349(+) AAAACA/GAAAGA 5 -- ds50010--------
    rs1448875941,2
    --74690357(+) AGAGAA/CTTTCG 5 -- ds50010--------
    rs1131698211,2
    C,F--74690361(+) ACTTTC/TGTCTA 5 -- ds50012Minor allele frequency- T:0.05CSA WA 120
    rs1457793501,2
    C--74690524(+) AGAAC-/ACAG  
            
    ACAGA
    5 -- ds50010--------
    rs1886015651,2
    --74690556(+) GAGACA/GCTAAA 5 -- ds50010--------

    HapMap Linkage Disequilibrium report for MBP (74690783 - 74845639 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MBP (see all 29):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717424CNV Deletion23290073
    esv2717426CNV Deletion23290073
    esv1000858CNV Deletion20482838
    esv2717430CNV Deletion23290073
    esv2425384CNV Deletion19546169
    esv1337607CNV Deletion17803354
    esv2717388CNV Deletion23290073
    esv2717428CNV Deletion23290073
    esv1249335CNV Deletion17803354
    esv2717427CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MBP
    DNA2.0 Custom Variant and Variant Library Synthesis for MBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 159430    OMIM disorders: --

    UniProtKB/Swiss-Prot: MBP_HUMAN, P02686
  • Note=The reduction in the surface charge of citrullinated and/or methylated MBP could result in a
    weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as
    chronical multiple sclerosis (MS), and fulminating MS (Marburg disease)

  • Selected diseases for MBP (see all 21):    
    About MalaCards
    akinetic mutism    chiari malformation    juvenile pilocytic astrocytoma    optic nerve glioma
    landau-kleffner syndrome    central pontine myelinolysis    dysgammaglobulinemia    transverse myelitis
    mutism    melanotic neuroectodermal tumor    ossifying fibromyxoid tumor    pelizaeus-merzbacher disease
    myelitis    pineocytoma    krabbe disease    chronic inflammatory demyelinating polyradiculoneuropathy
    central neurocytoma    polyradiculoneuropathy    acute disseminated encephalomyelitis    olivopontocerebellar atrophy

    9 diseases from the University of Copenhagen DISEASES database for MBP:
    Multiple sclerosis     Acute disseminated encephalomyelitis     Hypersensitivity reaction type II disease     Brain disease
    Neuropathy     Measles     Neuromyelitis optica     Subacute sclerosing panencephalitis
    Myelitis

    Find genes that share disorders with MBP           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MBP gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    multiple sclerosis 92.5 562 14714495 (7), 1690527 (4), 12465458 (4), 1694970 (4) (see all 99)
    encephalomyelitis 89.8 187 7512579 (2), 7689596 (2), 7504090 (2), 15292513 (2) (see all 99)
    demyelinating diseases 86.7 49 1384994 (2), 1718484 (1), 8632058 (1), 11234279 (1) (see all 30)
    demyelination 85.6 88 19726693 (2), 7508580 (2), 12465458 (2), 7525334 (2) (see all 60)
    18q- syndrome 74.4 5 8507907 (1), 9259379 (1), 8767586 (1), 14508777 (1)
    autoimmune diseases 72.7 29 8393796 (1), 10377791 (1), 8590314 (1), 7692995 (1) (see all 20)
    encephalomyelitis acute disseminated 70.6 2 12589368 (1), 17990580 (1)
    optic neuritis 70.4 16 7510787 (2), 7515411 (2), 7513391 (1), 7524258 (1) (see all 10)
    autoimmune response 69.8 29 1718484 (1), 7689820 (1), 7526591 (1), 9394837 (1) (see all 16)
    myelin degeneration 63.6 5 20091409 (1), 9094982 (1), 16900293 (1), 19359623 (1) (see all 5)

    Genetic Association Database (GAD): MBP
    Human Genome Epidemiology (HuGE) Navigator: MBP (391 documents)

    Export disorders for MBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MBP gene, integrated from 10 sources (see all 1283):
    (articles sorted by number of sources associating them with MBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of three forms of human myelin basic protein by cDNA cloning. (PubMed id 2425357)1, 2, 3 Kamholz J.... Lazzarini R.A. (Proc. Natl. Acad. Sci. U.S.A. 1986)
    2. [Polymorphism of length of tetranucleotide repeat from the 5'-side from the myelin basic protein gene in multiple sclerosis in Russians]. (PubMed id 14714495)1, 4, 9 AndreevskiA- T.V....Favorova O.O. (Mol. Biol. (Mosk.) 2003)
    3. Myelin basic protein gene is associated with MS in DR4- and DR5-positive Italians and Russians. (PubMed id 12939427)1, 4, 9 Guerini F.R....Favorova O.O. (Neurology 2003)
    4. The isolation and characterization of four myelin basic proteins from the unbound fraction during CM52 chromatography. (PubMed id 7574672)1, 2, 9 Boulias C.... Moscarello M.A. (Arch. Biochem. Biophys. 1995)
    5. Characteristic imprint of single nucleotide polymorphisms in multiple sclerosis. (PubMed id 18720029)1, 4, 9 Szolnoki Z....Somogyvari F. (J. Mol. Neurosci. 2009)
    6. Pharmacogenetics of glatiramer acetate therapy for multiple sclerosis reveals drug-response markers. (PubMed id 17622942)1, 4, 9 Grossman I....Miller A. (Pharmacogenet. Genomics 2007)
    7. Leukocyte gelatinase B cleavage releases encephalitogens from human myelin basic protein. (PubMed id 7685161)1, 2, 9 Proost P.... Opdenakker G. (Biochem. Biophys. Res. Commun. 1993)
    8. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    9. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    10. Association between golli-MBP and schizophrenia in the Jewish Ashkenazi population: are regulatory regions involved? (PubMed id 19154657)1, 4 Baruch K....Navon R. (Int. J. Neuropsychopharmacol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4155 HGNC: 6925 AceView: MBP Ensembl:ENSG00000197971 euGenes: HUgn4155
    ECgene: MBP H-InvDB: MBP

    (According to HUGE)
    About This Section

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MBP Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Myelin_basic_protein

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MBP gene:
    Search GeneIP for patents involving MBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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