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MBP Gene(Protein Coding)

Myelin Basic Protein

GCID:
GC18M076978
GIFtS:
68
Genes Participants
UDN Logo

Aliases for MBP Gene

Aliases for MBP Gene

  • Myelin Basic Protein 2 3 5
  • Myelin Membrane Encephalitogenic Protein 4
  • Myelin A1 Protein 4

External Ids for MBP Gene

Previous GeneCards Identifiers for MBP Gene

  • GC18M074281
  • GC18M074839
  • GC18M074453
  • GC18M072817
  • GC18M072819
  • GC18M074690
  • GC18M071371

Summaries for MBP Gene

Entrez Gene Summary for MBP Gene

  • The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for MBP Gene

MBP (Myelin Basic Protein) is a Protein Coding gene. Diseases associated with MBP include Central Pontine Myelinolysis and Acute Disseminated Encephalomyelitis. Among its related pathways are G-protein signaling Ras family GTPases in kinase cascades (scheme) and Glial Cell Differentiation. GO annotations related to this gene include protease binding and structural constituent of myelin sheath.

UniProtKB/Swiss-Prot for MBP Gene

  • The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

Tocris Summary for MBP Gene

Gene Wiki entry for MBP Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBP Gene

Genomics for MBP Gene

Products:

  1. Regulatory Element

Regulatory Elements for MBP Gene

Enhancers for MBP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MBP on UCSC Golden Path with GeneCards custom track

Promoters for MBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MBP on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MBP gene promoter:

Genomic Location for MBP Gene

Chromosome:
18
Start:
76,978,827 bp from pter
End:
77,133,708 bp from pter
Size:
154,882 bases
Orientation:
Minus strand

Genomic View for MBP Gene

Genes around MBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MBP Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MBP Gene

Proteins for MBP Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02686-MBP_HUMAN
    Recommended name:
    Myelin basic protein
    Protein Accession:
    P02686
    Secondary Accessions:
    • A4FU54
    • A6NI84
    • A8MY86
    • A8MYL4
    • B3KY66
    • B7ZKS2
    • B7ZKS4
    • Q15337
    • Q15338
    • Q15339
    • Q15340
    • Q59GX3
    • Q65ZS4
    • Q6AI64
    • Q6FH37
    • Q6FI04
    • Q6PK23

    Protein attributes for MBP Gene

    Size:
    304 amino acids
    Molecular mass:
    33117 Da
    Quaternary structure:
    • Homodimer. Isoform 3 exists as a homodimer.
    SequenceCaution:
    • Sequence=AAC41944.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The C-terminus contains a Histidine tag.; Evidence={ECO:0000305}; Sequence=BAD92223.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH10359.1; Type=Miscellaneous discrepancy; Note=wrong intron-exon boundaries.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MBP Gene

    Alternative splice isoforms for MBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MBP Gene

Proteomics data for MBP Gene at MOPED

Protein Expression for MBP Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MBP Gene

  • Arg-241 was found to be 6% monomethylated and 60% symmetrically dimethylated.
  • Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1.
  • Several charge isomers of MBP; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4, C5, C6, C7, C8-A and C8-B (the least cationic form); are produced as a result of optional PTM, such as phosphorylation, deamidation of glutamine or asparagine, arginine citrullination and methylation. C8-A and C8-B contain each two mass isoforms termed C8-A(H), C8-A(L), C8-B(H) and C8-B(L), (H) standing for higher and (L) for lower molecular weight. C3, C4 and C5 are phosphorylated. The ratio of methylated arginine residues decreases during aging, making the protein more cationic.
  • The N-terminal alanine is acetylated (isoform 3, isoform 4, isoform 5 and isoform 6).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MBP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MBP (MBP)

No data available for DME Specific Peptides for MBP Gene

Domains & Families for MBP Gene

Protein Domains for MBP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02686

UniProtKB/Swiss-Prot:

MBP_HUMAN :
  • Belongs to the myelin basic protein family.
Family:
  • Belongs to the myelin basic protein family.
genes like me logo Genes that share domains with MBP: view

No data available for Gene Families for MBP Gene

Function for MBP Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for MBP Gene

GENATLAS Biochemistry:
myelin,basic protein,major component of normal myelin of central nervous system,with three alternatively spliced isoforms
UniProtKB/Swiss-Prot Function:
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

Gene Ontology (GO) - Molecular Function for MBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17064692
GO:0019911 structural constituent of myelin sheath IEA,IBA --
genes like me logo Genes that share ontologies with MBP: view

Phenotypes for MBP Gene

MGI mutant phenotypes for MBP:
inferred from 6 alleles
GenomeRNAi human phenotypes for MBP:
genes like me logo Genes that share phenotypes with MBP: view

Animal Models for MBP Gene

MGI Knock Outs for MBP:

miRNA for MBP Gene

miRTarBase miRNAs that target MBP

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MBP Gene

Localization for MBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MBP Gene

Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.
Isoform 3: Nucleus. Note=Targeted to nucleus in oligodendrocytes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MBP Gene COMPARTMENTS Subcellular localization image for MBP gene
Compartment Confidence
cytoskeleton 4
nucleus 4
plasma membrane 4
cytosol 3
extracellular 2
vacuole 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042995 cell projection IEA --
GO:0043025 neuronal cell body IBA --
GO:0043218 compact myelin IBA --
genes like me logo Genes that share ontologies with MBP: view

Pathways & Interactions for MBP Gene

genes like me logo Genes that share pathways with MBP: view

Pathways by source for MBP Gene

1 Cell Signaling Technology pathway for MBP Gene

SIGNOR curated interactions for MBP Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for MBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 synaptic transmission TAS 2434243
GO:0007417 central nervous system development TAS 2434243
GO:0021762 substantia nigra development IEP 22926577
GO:0032570 response to progesterone IEA --
GO:0034612 response to tumor necrosis factor IEA --
genes like me logo Genes that share ontologies with MBP: view

Drugs & Compounds for MBP Gene

Products:

  1. Drug

(47) Drugs for MBP Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATX-MS-1467 Pharma 0

(61) Additional Compounds for MBP Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-O-Sulfogalactosylceramide (d18:1/24:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • 3-O-Sulphogalactosylceramide
 151122-71-3
B2
115687-05-3
Etifoxine hydrochloride
56776-32-0
MOG (35-55)
149635-73-4
Nogo-66 (1-40)
475221-20-6

(5) Tocris Compounds for MBP Gene

Compound Action Cas Number
B2 Promotes inclusion formation in Huntington's and Parkinson's diseases 115687-05-3
Etifoxine hydrochloride Potentiator of GABAA receptors; anxiolytic 56776-32-0
MOG (35-55) Encephalitogenic myelin oligodendrocyte glycoprotein fragment 149635-73-4
Nogo-66 (1-40) Competitive antagonist for Nogo-66 receptor; promotes neuron regeneration 475221-20-6
PLP (139-151) Encephalitogenic myelin proteolipid fragment 122018-58-0
genes like me logo Genes that share compounds with MBP: view

Transcripts for MBP Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for MBP Gene

(13) REFSEQ mRNAs :
(34) Additional mRNA sequences :
(1185) Selected AceView cDNA sequences:
(48) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MBP Gene

Myelin basic protein:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MBP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - - - -
SP6: -
SP7:
SP8:
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - -
SP11: - -
SP12: - - -
SP13: -
SP14:
SP15: -

ExUns: 14c · 14d ^ 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for MBP Gene

GeneLoc Exon Structure for
MBP
ECgene alternative splicing isoforms for
MBP

Expression for MBP Gene

Products:

  1. Primer

mRNA expression in normal human tissues for MBP Gene

mRNA expression in normal human tissues for MBP Gene
mRNA expression by BioGPS for MBP GenemRNA expression by GTEx for MBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MBP Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x22.1), Brain - Substantia nigra (x8.0), Brain - Hippocampus (x4.1), and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for MBP Gene

This gene is overexpressed in Spinal cord (37.6), Frontal cortex (16.5), and Brain (14.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MBP Gene



SOURCE GeneReport for Unigene cluster for MBP Gene Hs.551713

mRNA Expression by UniProt/SwissProt for MBP Gene

P02686-MBP_HUMAN
Tissue specificity: MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.
genes like me logo Genes that share expression patterns with MBP: view

Primer Products

No data available for Protein tissue co-expression partners for MBP Gene

Orthologs for MBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MBP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia MBP 35
  • 84.88 (n)
  • 85.43 (a)
MBP 36
  • 31 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia MBP 35
  • 86.51 (n)
  • 87.29 (a)
MBP 36
  • 53 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mbp 35
  • 88.35 (n)
  • 87.55 (a)
Mbp 16
Mbp 36
  • 65 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia MBP 35
  • 100 (n)
  • 100 (a)
MBP 36
  • 35 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia MBP 36
  • 47 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia MBP 36
  • 32 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves MBP 35
  • 71.66 (n)
  • 73.65 (a)
MBP 36
  • 25 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia MBP 36
  • 42 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia mbp 35
  • 69.7 (n)
  • 65.24 (a)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.25724 35
zebrafish
(Danio rerio)
 Actinopterygii mbpb 35
  • 61.48 (n)
  • 54.92 (a)
mbpb 36
  • 48 (a)
 OneToOne
Species with no ortholog for MBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MBP Gene

ENSEMBL:
Gene Tree for MBP (if available)
TreeFam:
Gene Tree for MBP (if available)

Paralogs for MBP Gene

No data available for Paralogs for MBP Gene

Variants for MBP Gene

Sequence variations from dbSNP and Humsavar for MBP Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs7964 -- 77,014,162(-) AGAAG(A/G)CATAT intron-variant, utr-variant-3-prime
rs12406 -- 77,013,113(+) GACTT(C/T)GAGAG intron-variant, utr-variant-3-prime
rs1584579 -- 77,127,923(-) GTGTG(A/T)GAGTG intron-variant, utr-variant-5-prime
rs1617144 -- 77,115,434(+) CTTCC(C/T)GAAAA intron-variant
rs1617173 -- 77,115,445(+) CACAG(A/G)TTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MBP Gene

Variant ID Type Subtype PubMed ID
esv2717388 CNV Deletion 23290073
nsv909946 CNV Gain 21882294
nsv526525 CNV Loss 19592680
nsv909947 CNV Loss 21882294
esv2717424 CNV Deletion 23290073
esv2717425 CNV Deletion 23290073
esv2717426 CNV Deletion 23290073
esv2669970 CNV Deletion 23128226
esv2717427 CNV Deletion 23290073
esv1337607 CNV Deletion 17803354
esv1000858 CNV Deletion 20482838
esv2578357 CNV Deletion 19546169
esv2717428 CNV Deletion 23290073
esv269268 CNV Insertion 20981092
esv996768 CNV Insertion 20482838
esv1353770 CNV Insertion 17803354
nsv130931 CNV Insertion 16902084
esv2425384 CNV Deletion 19546169
esv2008649 CNV Deletion 18987734
esv3092 CNV Deletion 18987735
esv2717430 CNV Deletion 23290073
esv9710 CNV Loss 19470904
esv2535215 CNV Deletion 19546169
esv999528 CNV Insertion 20482838
esv1080906 CNV Insertion 17803354
esv2717431 CNV Deletion 23290073
esv2663549 CNV Deletion 23128226
esv2717432 CNV Deletion 23290073
esv1249335 CNV Deletion 17803354

Variation tolerance for MBP Gene

Residual Variation Intolerance Score: 78.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.17; 51.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MBP Gene

Human Gene Mutation Database (HGMD)
MBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MBP Gene

Disorders for MBP Gene

MalaCards: The human disease database

(73) MalaCards diseases for MBP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
central pontine myelinolysis
  • central pontine myelinosis
acute disseminated encephalomyelitis
  • acute disseminated encephalitis
optic neuritis
relapsing-remitting multiple sclerosis
  • relapsing-remitting ms
secondary progressive multiple sclerosis
  • secondary-progressive ms
- elite association - COSMIC cancer census association via MalaCards
Search MBP in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MBP_HUMAN
  • Note=The reduction in the surface charge of citrullinated and/or methylated MBP could result in a weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as chronical multiple sclerosis (MS), and fulminating MS (Marburg disease).

Relevant External Links for MBP

Genetic Association Database (GAD)
MBP
Human Genome Epidemiology (HuGE) Navigator
MBP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MBP
genes like me logo Genes that share disorders with MBP: view

No data available for Genatlas for MBP Gene

Publications for MBP Gene

  1. Identification of three forms of human myelin basic protein by cDNA cloning. (PMID: 2425357) Kamholz J. … Lazzarini R.A. (Proc. Natl. Acad. Sci. U.S.A. 1986) 2 3 4 67
  2. [Expression of myelin basic protein and glial fibrillary acidic protein genes in human glial brain tumors]. (PMID: 19663312) Dmytrenko V.V. … Kavsan V.M. (Tsitol. Genet. 2009) 3 23
  3. Pharmacogenetics of glatiramer acetate therapy for multiple sclerosis reveals drug-response markers. (PMID: 17622942) Grossman I. … Miller A. (Pharmacogenet. Genomics 2007) 3 23
  4. Myelin basic protein, an autoantigen in multiple sclerosis, is selectively processed by human trypsin 4. (PMID: 16412431) Medveczky P. … GrA!f L. (FEBS Lett. 2006) 3 23
  5. Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel. (PMID: 14594813) Ryazanova L.V. … Ryazanov A.G. (J. Biol. Chem. 2004) 3 23

Products for MBP Gene

Sources for MBP Gene

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