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Aliases for MBOAT7 Gene

Aliases for MBOAT7 Gene

  • Membrane Bound O-Acyltransferase Domain Containing 7 2 3
  • Lysophosphatidylinositol Acyltransferase 2 3 4
  • LENG4 3 4 6
  • BB1 3 4 6
  • Bladder And Breast Carcinoma-Overexpressed Gene 1 Protein 3 4
  • 1-Acylglycerophosphatidylinositol O-Acyltransferase 3 4
  • Leukocyte Receptor Cluster (LRC) Member 4 2 3
  • Lyso-PI Acyltransferase 3 4
  • H-Mboa-7 3 4
  • LPLAT 7 3 4
  • LPIAT 3 4
  • OACT7 3 4
  • Malignant Cell Expression-Enhanced Gene/Tumor Progression-Enhanced 3
  • Membrane-Bound O-Acyltransferase Domain-Containing Protein 7 4
  • O-Acyltransferase Domain-Containing Protein 7 4
  • Leukocyte Receptor Cluster Member 4 4
  • Lysophospholipid Acyltransferase 7 3
  • EC 2.3.1.n4 4
  • EC 2.3.1.- 4
  • HMBOA-7 3
  • MBOA7 3
  • LRC4 3

External Ids for MBOAT7 Gene

Previous HGNC Symbols for MBOAT7 Gene

  • LENG4

Previous GeneCards Identifiers for MBOAT7 Gene

  • GC19M059374
  • GC19M054677
  • GC19M050993

Summaries for MBOAT7 Gene

Entrez Gene Summary for MBOAT7 Gene

  • This gene encodes a member of the membrane-bound O-acyltransferases family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the reacylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

GeneCards Summary for MBOAT7 Gene

MBOAT7 (Membrane Bound O-Acyltransferase Domain Containing 7) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups. An important paralog of this gene is MBOAT2.

UniProtKB/Swiss-Prot for MBOAT7 Gene

  • Acyltransferase which mediates the conversion of lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBOAT7 Gene

Genomics for MBOAT7 Gene

Regulatory Elements for MBOAT7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MBOAT7 Gene

Start:
54,173,412 bp from pter
End:
54,189,882 bp from pter
Size:
16,471 bases
Orientation:
Minus strand

Genomic View for MBOAT7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MBOAT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MBOAT7 Gene

Proteins for MBOAT7 Gene

  • Protein details for MBOAT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96N66-MBOA7_HUMAN
    Recommended name:
    Lysophospholipid acyltransferase 7
    Protein Accession:
    Q96N66
    Secondary Accessions:
    • A9C4B6
    • B0V3I5
    • B4DQ87
    • Q05DF0
    • Q7L5N2
    • Q99908
    • Q9BPV2
    • Q9BRE9

    Protein attributes for MBOAT7 Gene

    Size:
    472 amino acids
    Molecular mass:
    52765 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB37433.1; Type=Frameshift; Positions=63, 93, 144, 186; Evidence={ECO:0000305};

    Alternative splice isoforms for MBOAT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MBOAT7 Gene

Proteomics data for MBOAT7 Gene at MOPED

Post-translational modifications for MBOAT7 Gene

  • Ubiquitination at Lys288, Lys456, and Lys468
  • Glycosylation at Asn321
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MBOAT7 Gene

Domains for MBOAT7 Gene

Protein Domains for MBOAT7 Gene

Suggested Antigen Peptide Sequences for MBOAT7 Gene

Graphical View of Domain Structure for InterPro Entry

Q96N66

UniProtKB/Swiss-Prot:

MBOA7_HUMAN :
  • Q96N66
Family:
  • Belongs to the membrane-bound acyltransferase family.
genes like me logo Genes that share domains with MBOAT7: view

No data available for Gene Families for MBOAT7 Gene

Function for MBOAT7 Gene

Molecular function for MBOAT7 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + 1-acyl-sn-glycero-3-phosphatidylinositol = CoA + 1,2-diacyl-sn-glycero-3-phosphatidylinositol.
UniProtKB/Swiss-Prot CatalyticActivity: Acyl-[acyl-carrier-protein] + 1-acyl-sn-glycerol 3-phosphate = [acyl-carrier-protein] + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Activity is inhibited by thimerosal
UniProtKB/Swiss-Prot Function: Acyltransferase which mediates the conversion of lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.

Enzyme Numbers (IUBMB) for MBOAT7 Gene

Gene Ontology (GO) - Molecular Function for MBOAT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21903422
GO:0071617 lysophospholipid acyltransferase activity IEA --
genes like me logo Genes that share ontologies with MBOAT7: view
genes like me logo Genes that share phenotypes with MBOAT7: view

Animal Models for MBOAT7 Gene

MGI Knock Outs for MBOAT7:

Animal Model Products

CRISPR Products

miRNA for MBOAT7 Gene

miRTarBase miRNAs that target MBOAT7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MBOAT7

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for MBOAT7 Gene

Localization for MBOAT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MBOAT7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MBOAT7 Gene COMPARTMENTS Subcellular localization image for MBOAT7 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
extracellular 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for MBOAT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MBOAT7: view

Pathways for MBOAT7 Gene

genes like me logo Genes that share pathways with MBOAT7: view

Pathways by source for MBOAT7 Gene

UniProtKB/Swiss-Prot Q96N66-MBOA7_HUMAN

  • Pathway: Lipid metabolism; phospholipid metabolism.

Interacting Proteins for MBOAT7 Gene

Gene Ontology (GO) - Biological Process for MBOAT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0021591 ventricular system development IEA --
GO:0021819 layer formation in cerebral cortex IEA --
GO:0036149 phosphatidylinositol acyl-chain remodeling TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with MBOAT7: view

Transcripts for MBOAT7 Gene

Unigene Clusters for MBOAT7 Gene

Membrane bound O-acyltransferase domain containing 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MBOAT7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MBOAT7 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11
SP1: - -
SP2: - -
SP3: -
SP4: - - - - -
SP5:
SP6: - -
SP7: - - -
SP8: - -
SP9: -

Relevant External Links for MBOAT7 Gene

GeneLoc Exon Structure for
MBOAT7
ECgene alternative splicing isoforms for
MBOAT7

Expression for MBOAT7 Gene

mRNA expression in normal human tissues for MBOAT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MBOAT7 Gene

This gene is overexpressed in Whole Blood (15.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MBOAT7 Gene

SOURCE GeneReport for Unigene cluster for MBOAT7 Gene Hs.467279

mRNA Expression by UniProt/SwissProt for MBOAT7 Gene

Q96N66-MBOA7_HUMAN
Tissue specificity: Overexpressed in metastatic breast and bladder carcinomas relative to normal breast epithelium and urothelium.
genes like me logo Genes that share expressions with MBOAT7: view

In Situ Assay Products

Orthologs for MBOAT7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MBOAT7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MBOAT7 35
  • 99.44 (n)
  • 99.79 (a)
MBOAT7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MBOAT7 35
  • 91.74 (n)
  • 94.28 (a)
MBOAT7 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MBOAT7 35
  • 91.81 (n)
  • 95.97 (a)
MBOAT7 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mboat7 35
  • 89.12 (n)
  • 93.86 (a)
Mboat7 16
Mboat7 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MBOAT7 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mboat7 35
  • 89.48 (n)
  • 94.07 (a)
lizard
(Anolis carolinensis)
Reptilia MBOAT7 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mboat7 35
  • 62.14 (n)
  • 62 (a)
zebrafish
(Danio rerio)
Actinopterygii mboat7 35
  • 59.52 (n)
  • 59.67 (a)
mboat7 36
  • 56 (a)
OneToOne
zgc66032 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009259 35
  • 50.4 (n)
  • 34.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta frj 35
  • 48.5 (n)
  • 34.14 (a)
frj 36
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mboa-7 35
  • 42.94 (n)
  • 30.51 (a)
mboa-7 36
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALE1 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToOne
Species with no ortholog for MBOAT7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MBOAT7 Gene

ENSEMBL:
Gene Tree for MBOAT7 (if available)
TreeFam:
Gene Tree for MBOAT7 (if available)

Paralogs for MBOAT7 Gene

Paralogs for MBOAT7 Gene

genes like me logo Genes that share paralogs with MBOAT7: view

Variants for MBOAT7 Gene

Sequence variations from dbSNP and Humsavar for MBOAT7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs36626 -- 54,188,125(+) CTAGA(C/G)ATGAG intron-variant
rs36627 -- 54,187,895(+) CTGTA(A/G)TCCCA intron-variant
rs36628 -- 54,187,876(+) CAGGC(A/G)TGGTG intron-variant
rs36629 -- 54,187,845(+) ACCCC(A/G)GCTCT intron-variant
rs36630 -- 54,187,744(+) CGGAT(A/G)CGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MBOAT7 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
dgv4001n71 CNV Loss 21882294
nsv515623 CNV Loss 19592680
dgv4002n71 CNV Loss 21882294
nsv912398 CNV Loss 21882294
nsv510774 CNV Loss 20534489
nsv9751 CNV Gain 18304495
dgv1118e1 CNV Complex 17122850
nsv428371 CNV Gain+Loss 18775914
dgv1119e1 CNV Complex 17122850
esv2658376 CNV Deletion 23128226
esv1201253 CNV Deletion 17803354
nsv2546 CNV Loss 18451855

Relevant External Links for MBOAT7 Gene

HapMap Linkage Disequilibrium report
MBOAT7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MBOAT7 Gene

Disorders for MBOAT7 Gene

No disorders were found for MBOAT7 Gene.

No data available for UniProtKB/Swiss-Prot for MBOAT7 Gene

Publications for MBOAT7 Gene

  1. Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol. (PMID: 18094042) Lee H.C. … Arai H. (Mol. Biol. Cell 2008) 2 3 4
  2. Molecular analysis of a gene, BB1, overexpressed in bladder and breast carcinoma. (PMID: 8702217) Fukunaga-Johnson N. … Grossman H.B. (Anticancer Res. 1996) 2 3 4
  3. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H. … Ziegler A. (Immunogenetics 2000) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils. (PMID: 18772128) Gijon M.A. … Voelker D.R. (J. Biol. Chem. 2008) 3 4

Products for MBOAT7 Gene

Sources for MBOAT7 Gene

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