MBOAT4 Gene
protein-coding GIFtS: 38
GCID: GC08M029989
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membrane bound O-acyltransferase domain containing 4(Previous name: O-acyltransferase (membrane bound) domain containing 4...)
(Previous symbol: OACT4)
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Aliases
for MBOAT4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Membrane Bound O-Acyltransferase Domain Containing 41 2 | | O-Acyltransferase Domain-Containing Protein 42 3 | | GOAT1 2 3 5 | | FKSG891 | | OACT41 2 3 | | Ghrelin O-Acyltransferase2 | | O-Acyltransferase (Membrane Bound) Domain Containing 41 2 | | EC 2.3.1.-3 | | Membrane-Bound O-Acyltransferase Domain-Containing Protein 42 3 | | |
Export aliases for MBOAT4 gene to outside databasesPrevious GC identifers: GC08M030108 GC08M028533 |
Summaries
for MBOAT4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MBOA4_HUMAN, Q96T53Function: Mediates the octanoylation of ghrelin at 'Ser-3'. Can use a variety of fatty acids as substrates includingoctanoic acid, decanoic acid and tetradecanoic acid
|
Genomic Views
for MBOAT4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MBOAT4 gene promoter:
c-Fos AP-1 JunB Lmo2 Fra-1 FosB GATA-6 FOXC1 JunD c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for MBOAT4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MBOAT4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p12 Ensembl cytogenetic band: 8p12 HGNC cytogenetic band: 8p12MBOAT4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M029989: view genomic region
(about GC identifiers)
Start:
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29,989,187 bp from pter |
End:
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30,002,202 bp from pter |
Size:
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13,016 bases |
Orientation:
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minus strand |
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Proteins
for MBOAT4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MBOA4_HUMAN, Q96T53 (See
protein sequence)Recommended Name: Ghrelin O-acyltransferase Size: 435 amino acids; 49716 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: B1Q003Alternative splicing: 2 isoforms: Q96T53-1 Q96T53-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MBOAT4: NX_Q96T53
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96T53
MBOAT4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001094386.1
ENSEMBL proteins: ENSP00000314196 Reactome Protein details: Q96T53
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005789 | endoplasmic reticulum membrane |
TAS | -- | | GO:0030176 | integral to endoplasmic reticulum membrane |
ISS | -- |
MBOAT4 for ontologies About GeneDecksing
MBOAT4 Antibody Products:
Assay Products for MBOAT4: |
Protein
Domains /
Families
for MBOAT4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MBOAT4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96T53ProtoNet protein and cluster: Q96T53 UniProtKB/Swiss-Prot: MBOA4_HUMAN, Q96T53Similarity: Belongs to the membrane-bound acyltransferase family |
Function
for MBOAT4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MBOA4_HUMAN, Q96T53Function: Mediates the octanoylation of ghrelin at 'Ser-3'. Can use a variety of fatty acids as substrates includingoctanoic acid, decanoic acid and tetradecanoic acidEnzyme Number (IUBMB): EC 2.3.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MBOAT4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MBOAT4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: MBOAT4 (NM_001100916) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MBOAT4 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MBOAT4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MBOAT4 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016412 | serine O-acyltransferase activity |
IDA | 18443287 |
MBOAT4 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Mboat4tm1Jagu for MBOAT4
5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Mboat4):
MBOAT4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MBOAT4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | | | 2 | Insulin Processing | | | 3 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for MBOAT4
MBOAT4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MBOAT4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for MBOAT4 (ENSP000003141964) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0018191 | peptidyl-serine octanoylation |
IDA | 18443287 |
MBOAT4 for ontologies About GeneDecksing
|
Drugs & Compounds
for MBOAT4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MBOAT4
Search CenterWatch for drugs/clinical trials and news about MBOAT4 / MBOA4
|
Transcripts
for MBOAT4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MBOAT4 gene: NM_001100916.1 Unigene Cluster for MBOAT4: Membrane bound O-acyltransferase domain containing 4 Hs.627194 [show with all ESTs]Unigene Representative Sequence: NM_0011009161 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000320542(uc010lvg.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MBOAT4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MBOAT4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MBOAT4 (NM_001100916) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MBOAT4 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MBOAT4 |
Additional cDNA sequence: EU518495.2 1 DOTS entry: DT.120629872
GeneLoc Exon Structure
|
Expression
for MBOAT4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MBOAT4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MBOAT4 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.627194
UniProtKB/Swiss-Prot: MBOA4_HUMAN, Q96T53Tissue specificity: Expressed predominantly in stomach with moderate levels in pancreas and relatively low levels inmost other tissues
SABiosciences Custom PCR Arrays for MBOAT4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MBOAT4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MBOAT4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MBOAT4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MBOAT4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MBOAT4 |
Orthologs
for MBOAT4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MBOAT4 gene from 4/9 species (see all 9) About this table
ENSEMBL Gene Tree for MBOAT4 (if available)
TreeFam Gene Tree for MBOAT4 (if available) |
Paralogs
for MBOAT4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MBOAT4 gene
- LPCAT32 MBOAT12 MBOAT72 MBOAT22
MBOAT4 for paralogs About GeneDecksing
|
Genomic Variants
for MBOAT4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MBOAT4 (29989187 - 30002202 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MBOAT4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MBOAT4 |
|
Disorders
/ Diseases
for MBOAT4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MBOAT4 for disorders About GeneDecksing
OMIM gene information: 611940
OMIM disorders: --
3  diseases for MBOAT4: About MalaCardsanorexia nervosa gastroparesis ileus
Human Genome Epidemiology (HuGE) Navigator: MBOAT4 (1 document)
Export disorders for MBOAT4 gene to outside databases
|
Publications
for MBOAT4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MBOAT4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MBOAT4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Ghrelin octanoylation mediated by an orphan lipid transferase. (PubMed id 18443287)1, 2, 3 Gutierrez J.A.... Hale J.E. (2008)
- The expression of ghrelin O-acyltransferase (GOAT) in human tissues. (PubMed id 21646729)1 Lim C.T....Korbonits M. (2011)
- The ghrelin O-acyltransferase-ghrelin system: a novel regulator of glucose metabolism. (PubMed id 21150588)1 Heppner K.M....TschAPp M.H. (2011)
- Genetic studies on the ghrelin, growth hormone secreta gogue receptor (GHSR) and ghrelin O-acyl transferase (GOAT) genes. (PubMed id 21930173)1 Liu B....Korbonits M. (2011)
- Genetic variation of the ghrelin activator gene ghrel in O-acyltransferase (GOAT) is associated with anorexia nervosa. (PubMed id 21035823)1 MA1ller T.D....Hinney A. (2010)
- Expression and modulation of ghrelin O-acyltransferas e in cultured chondrocytes. (PubMed id 19479831)1 GA^mez R....Gualillo O. (2009)
- Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, a s well as n-octanoic acid. (PubMed id 19628676)1 Takahashi T....Kojima M. (2009)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
|
External Searches for MBOAT4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MBOAT4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MBOAT4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MBOAT4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MBOAT4 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MBOAT4 gene:
Search GeneIP for patents involving MBOAT4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MBOAT4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MBOAT4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MBOAT4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MBOAT4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MBOAT4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MBOAT4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MBOAT4 |
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 | | | MBOAT4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MBOAT4 |
|  |  |  | | | | Search ThermoFisher Antibodies for MBOAT4 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MBOAT4 |
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