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Aliases for MBOAT4 Gene

Aliases for MBOAT4 Gene

  • Membrane Bound O-Acyltransferase Domain Containing 4 2 3
  • Membrane-Bound O-Acyltransferase Domain-Containing Protein 4 3 4
  • O-Acyltransferase (Membrane Bound) Domain Containing 4 2 3
  • O-Acyltransferase Domain-Containing Protein 4 3 4
  • OACT4 3 4
  • GOAT 3 4
  • Ghrelin O-Acyltransferase 2
  • EC 2.3.1.- 4
  • FKSG89 3

External Ids for MBOAT4 Gene

Previous HGNC Symbols for MBOAT4 Gene

  • OACT4

Previous GeneCards Identifiers for MBOAT4 Gene

  • GC08M030108
  • GC08M029989
  • GC08M028533

Summaries for MBOAT4 Gene

GeneCards Summary for MBOAT4 Gene

MBOAT4 (Membrane Bound O-Acyltransferase Domain Containing 4) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Peptide hormone metabolism. GO annotations related to this gene include serine O-acyltransferase activity. An important paralog of this gene is MBOAT7.

UniProtKB/Swiss-Prot for MBOAT4 Gene

  • Mediates the octanoylation of ghrelin at Ser-3. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBOAT4 Gene

Genomics for MBOAT4 Gene

Regulatory Elements for MBOAT4 Gene

Genomic Location for MBOAT4 Gene

Chromosome:
8
Start:
30,131,454 bp from pter
End:
30,158,699 bp from pter
Size:
27,246 bases
Orientation:
Minus strand

Genomic View for MBOAT4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MBOAT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MBOAT4 Gene

Proteins for MBOAT4 Gene

  • Protein details for MBOAT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T53-MBOA4_HUMAN
    Recommended name:
    Ghrelin O-acyltransferase
    Protein Accession:
    Q96T53
    Secondary Accessions:
    • B1Q003

    Protein attributes for MBOAT4 Gene

    Size:
    435 amino acids
    Molecular mass:
    49716 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MBOAT4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MBOAT4 Gene

Proteomics data for MBOAT4 Gene at MOPED

Post-translational modifications for MBOAT4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MBOAT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MBOAT4 Gene

Domains & Families for MBOAT4 Gene

Gene Families for MBOAT4 Gene

Protein Domains for MBOAT4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MBOAT4 Gene

Graphical View of Domain Structure for InterPro Entry

Q96T53

UniProtKB/Swiss-Prot:

MBOA4_HUMAN :
  • Belongs to the membrane-bound acyltransferase family.
Family:
  • Belongs to the membrane-bound acyltransferase family.
genes like me logo Genes that share domains with MBOAT4: view

Function for MBOAT4 Gene

Molecular function for MBOAT4 Gene

UniProtKB/Swiss-Prot Function:
Mediates the octanoylation of ghrelin at Ser-3. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid.

Enzyme Numbers (IUBMB) for MBOAT4 Gene

Gene Ontology (GO) - Molecular Function for MBOAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016412 serine O-acyltransferase activity IDA 18443287
genes like me logo Genes that share ontologies with MBOAT4: view
genes like me logo Genes that share phenotypes with MBOAT4: view

Animal Models for MBOAT4 Gene

MGI Knock Outs for MBOAT4:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MBOAT4

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for MBOAT4 Gene

Localization for MBOAT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MBOAT4 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MBOAT4 Gene COMPARTMENTS Subcellular localization image for MBOAT4 gene
Compartment Confidence
endoplasmic reticulum 4
nucleus 1

Gene Ontology (GO) - Cellular Components for MBOAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0030176 integral component of endoplasmic reticulum membrane ISS --
genes like me logo Genes that share ontologies with MBOAT4: view

Pathways & Interactions for MBOAT4 Gene

genes like me logo Genes that share pathways with MBOAT4: view

Pathways by source for MBOAT4 Gene

Interacting Proteins for MBOAT4 Gene

Gene Ontology (GO) - Biological Process for MBOAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018191 peptidyl-serine octanoylation IDA 18443287
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MBOAT4: view

No data available for SIGNOR curated interactions for MBOAT4 Gene

Drugs & Compounds for MBOAT4 Gene

No Compound Related Data Available

Transcripts for MBOAT4 Gene

mRNA/cDNA for MBOAT4 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MBOAT4 Gene

Membrane bound O-acyltransferase domain containing 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MBOAT4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MBOAT4 Gene

No ASD Table

Relevant External Links for MBOAT4 Gene

GeneLoc Exon Structure for
MBOAT4
ECgene alternative splicing isoforms for
MBOAT4

Expression for MBOAT4 Gene

mRNA expression in normal human tissues for MBOAT4 Gene

mRNA differential expression in normal tissues according to GTEx for MBOAT4 Gene

This gene is overexpressed in Pancreas (x8.3) and Testis (x6.3).

SOURCE GeneReport for Unigene cluster for MBOAT4 Gene Hs.627194

mRNA Expression by UniProt/SwissProt for MBOAT4 Gene

Q96T53-MBOA4_HUMAN
Tissue specificity: Expressed predominantly in stomach with moderate levels in pancreas and relatively low levels in most other tissues.
genes like me logo Genes that share expression patterns with MBOAT4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MBOAT4 Gene

Orthologs for MBOAT4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MBOAT4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MBOAT4 35
  • 80.61 (n)
  • 79.54 (a)
MBOAT4 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MBOAT4 35
  • 83.75 (n)
  • 81.15 (a)
MBOAT4 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mboat4 35
  • 80.84 (n)
  • 78.62 (a)
Mboat4 16
Mboat4 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MBOAT4 35
  • 99.08 (n)
  • 98.39 (a)
MBOAT4 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mboat4 35
  • 81.23 (n)
  • 78.16 (a)
oppossum
(Monodelphis domestica)
Mammalia MBOAT4 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves MBOAT4 35
  • 59.9 (n)
  • 54.52 (a)
MBOAT4 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MBOAT4 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487840 35
  • 56.34 (n)
  • 49.17 (a)
zebrafish
(Danio rerio)
Actinopterygii mboat4 35
  • 50.42 (n)
  • 39.25 (a)
mboat4 36
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta oys 36
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mboa-3 36
  • 15 (a)
ManyToMany
mboa-4 36
  • 15 (a)
ManyToMany
mboa-5 36
  • 17 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALE1 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10638 36
  • 19 (a)
OneToMany
Species with no ortholog for MBOAT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MBOAT4 Gene

ENSEMBL:
Gene Tree for MBOAT4 (if available)
TreeFam:
Gene Tree for MBOAT4 (if available)

Paralogs for MBOAT4 Gene

Paralogs for MBOAT4 Gene

genes like me logo Genes that share paralogs with MBOAT4: view

Variants for MBOAT4 Gene

Sequence variations from dbSNP and Humsavar for MBOAT4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1877183 -- 30,142,653(-) CTGGC(C/T)GGATG intron-variant
rs1877184 -- 30,142,424(-) AAGTC(C/G)TGATT intron-variant
rs1910367 -- 30,145,585(-) ccacc(A/G)cagcc upstream-variant-2KB, intron-variant
rs2134562 -- 30,147,910(+) tcttt(C/T)CCAAA intron-variant
rs2134563 -- 30,147,982(+) gggac(A/G)tatca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MBOAT4 Gene

Variant ID Type Subtype PubMed ID
nsv831277 CNV Gain 17160897
esv2736827 CNV Deletion 23290073

Variation tolerance for MBOAT4 Gene

Gene Damage Index Score: 3.17; 51.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MBOAT4 Gene

HapMap Linkage Disequilibrium report
MBOAT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MBOAT4 Gene

Disorders for MBOAT4 Gene

Relevant External Links for MBOAT4

Human Genome Epidemiology (HuGE) Navigator
MBOAT4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MBOAT4
genes like me logo Genes that share disorders with MBOAT4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MBOAT4 Gene

Publications for MBOAT4 Gene

  1. Ghrelin octanoylation mediated by an orphan lipid transferase. (PMID: 18443287) Gutierrez J.A. … Hale J.E. (Proc. Natl. Acad. Sci. U.S.A. 2008) 2 67
  2. Structure-activity analysis of human ghrelin O-acyltransferase reveals chemical determinants of ghrelin selectivity and acyl group recognition. (PMID: 25562443) Darling J.E. … Hougland J.L. (Biochemistry 2015) 67
  3. Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight. (PMID: 24194510) Gahete M.D. … Luque R.M. (J. Endocrinol. 2014) 67
  4. Architectural organization of the metabolic regulatory enzyme ghrelin O-acyltransferase. (PMID: 24045953) Taylor M.S. … Cole P.A. (J. Biol. Chem. 2013) 67
  5. The ghrelin activating enzyme ghrelin-O-acyltransferase (GOAT) is present in human plasma and expressed dependent on body mass index. (PMID: 23454172) Goebel-Stengel M. … Stengel A. (Peptides 2013) 67

Products for MBOAT4 Gene

Sources for MBOAT4 Gene

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