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Aliases for MBOAT4 Gene

Aliases for MBOAT4 Gene

  • Membrane Bound O-Acyltransferase Domain Containing 4 2 3 5
  • Membrane-Bound O-Acyltransferase Domain-Containing Protein 4 3 4
  • O-Acyltransferase (Membrane Bound) Domain Containing 4 2 3
  • O-Acyltransferase Domain-Containing Protein 4 3 4
  • Ghrelin O-Acyltransferase 2 3
  • OACT4 3 4
  • GOAT 3 4
  • EC 2.3.1.- 4
  • FKSG89 3

External Ids for MBOAT4 Gene

Previous HGNC Symbols for MBOAT4 Gene

  • OACT4

Previous GeneCards Identifiers for MBOAT4 Gene

  • GC08M030108
  • GC08M029989
  • GC08M028533

Summaries for MBOAT4 Gene

GeneCards Summary for MBOAT4 Gene

MBOAT4 (Membrane Bound O-Acyltransferase Domain Containing 4) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Peptide hormone metabolism. GO annotations related to this gene include serine O-acyltransferase activity. An important paralog of this gene is MBOAT2.

UniProtKB/Swiss-Prot for MBOAT4 Gene

  • Mediates the octanoylation of ghrelin at Ser-3. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBOAT4 Gene

Genomics for MBOAT4 Gene

Regulatory Elements for MBOAT4 Gene

Enhancers for MBOAT4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G030088 2 FANTOM5 Ensembl ENCODE dbSUPER 5.4 +65.9 65914 9.2 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 ZNF766 FOS NFYC REST LEPROTL1 SARAF HSPA8P11 MBOAT4
GH08G030097 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.3 +58.7 58688 4.6 PKNOX1 FOXA2 ATF1 CREB3L1 MLX ZNF133 ARID4B DMAP1 YY1 FOS LEPROTL1 SARAF MBOAT4 GC08M030097 RPS15AP24
GH08G030075 1.5 FANTOM5 Ensembl ENCODE dbSUPER 5.2 +81.9 81935 1.6 FEZF1 ZNF316 CBX5 GATA2 NFE2 IKZF2 MAFK ZNF362 MAFG DPF2 LEPROTL1 SARAF MBOAT4 ENSG00000272256 RNU6-1218P
GH08G030059 1.3 Ensembl ENCODE dbSUPER 5.3 +98.7 98651 1.4 TBP CTCF JUN KLF17 FOSL1 ZNF121 POLR3A FOS SMARCE1 ZNF362 LEPROTL1 SARAF DUSP4 MBOAT4 RNU6-1218P ENSG00000272256
GH08G030419 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.2 -263.3 -263349 4.8 ATF1 FOXA2 ARNT ZFP64 FEZF1 ZNF48 TCF12 GATA2 FOS REST RBPMS-AS1 RBPMS GTF2E2 MBOAT4 PIR31328
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MBOAT4 on UCSC Golden Path with GeneCards custom track

Genomic Location for MBOAT4 Gene

Chromosome:
8
Start:
30,131,454 bp from pter
End:
30,158,699 bp from pter
Size:
27,246 bases
Orientation:
Minus strand

Genomic View for MBOAT4 Gene

Genes around MBOAT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MBOAT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MBOAT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MBOAT4 Gene

Proteins for MBOAT4 Gene

  • Protein details for MBOAT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T53-MBOA4_HUMAN
    Recommended name:
    Ghrelin O-acyltransferase
    Protein Accession:
    Q96T53
    Secondary Accessions:
    • B1Q003

    Protein attributes for MBOAT4 Gene

    Size:
    435 amino acids
    Molecular mass:
    49716 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MBOAT4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MBOAT4 Gene

Post-translational modifications for MBOAT4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MBOAT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MBOAT4 Gene

Domains & Families for MBOAT4 Gene

Gene Families for MBOAT4 Gene

Protein Domains for MBOAT4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MBOAT4 Gene

Graphical View of Domain Structure for InterPro Entry

Q96T53

UniProtKB/Swiss-Prot:

MBOA4_HUMAN :
  • Belongs to the membrane-bound acyltransferase family.
Family:
  • Belongs to the membrane-bound acyltransferase family.
genes like me logo Genes that share domains with MBOAT4: view

Function for MBOAT4 Gene

Molecular function for MBOAT4 Gene

UniProtKB/Swiss-Prot Function:
Mediates the octanoylation of ghrelin at Ser-3. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid.

Enzyme Numbers (IUBMB) for MBOAT4 Gene

Gene Ontology (GO) - Molecular Function for MBOAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008374 O-acyltransferase activity TAS --
GO:0016412 serine O-acyltransferase activity IDA 18443287
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with MBOAT4: view
genes like me logo Genes that share phenotypes with MBOAT4: view

Animal Models for MBOAT4 Gene

MGI Knock Outs for MBOAT4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MBOAT4 Gene

Localization for MBOAT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MBOAT4 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MBOAT4 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for MBOAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030176 integral component of endoplasmic reticulum membrane IEA,ISS --
genes like me logo Genes that share ontologies with MBOAT4: view

Pathways & Interactions for MBOAT4 Gene

genes like me logo Genes that share pathways with MBOAT4: view

Pathways by source for MBOAT4 Gene

Interacting Proteins for MBOAT4 Gene

Gene Ontology (GO) - Biological Process for MBOAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018191 peptidyl-serine octanoylation IDA 18443287
genes like me logo Genes that share ontologies with MBOAT4: view

No data available for SIGNOR curated interactions for MBOAT4 Gene

Drugs & Compounds for MBOAT4 Gene

No Compound Related Data Available

Transcripts for MBOAT4 Gene

mRNA/cDNA for MBOAT4 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MBOAT4 Gene

Membrane bound O-acyltransferase domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MBOAT4 Gene

No ASD Table

Relevant External Links for MBOAT4 Gene

GeneLoc Exon Structure for
MBOAT4
ECgene alternative splicing isoforms for
MBOAT4

Expression for MBOAT4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MBOAT4 Gene

mRNA differential expression in normal tissues according to GTEx for MBOAT4 Gene

This gene is overexpressed in Pancreas (x8.3) and Testis (x6.3).

NURSA nuclear receptor signaling pathways regulating expression of MBOAT4 Gene:

MBOAT4

SOURCE GeneReport for Unigene cluster for MBOAT4 Gene:

Hs.627194

mRNA Expression by UniProt/SwissProt for MBOAT4 Gene:

Q96T53-MBOA4_HUMAN
Tissue specificity: Expressed predominantly in stomach with moderate levels in pancreas and relatively low levels in most other tissues.

Evidence on tissue expression from TISSUES for MBOAT4 Gene

  • Stomach(2.6)
genes like me logo Genes that share expression patterns with MBOAT4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MBOAT4 Gene

Orthologs for MBOAT4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MBOAT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MBOAT4 34 35
  • 99.08 (n)
dog
(Canis familiaris)
Mammalia MBOAT4 34 35
  • 83.75 (n)
rat
(Rattus norvegicus)
Mammalia Mboat4 34
  • 81.23 (n)
mouse
(Mus musculus)
Mammalia Mboat4 34 16 35
  • 80.84 (n)
cow
(Bos Taurus)
Mammalia MBOAT4 34 35
  • 80.61 (n)
oppossum
(Monodelphis domestica)
Mammalia MBOAT4 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves MBOAT4 34 35
  • 59.9 (n)
lizard
(Anolis carolinensis)
Reptilia MBOAT4 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487840 34
  • 56.34 (n)
zebrafish
(Danio rerio)
Actinopterygii mboat4 34 35
  • 50.42 (n)
fruit fly
(Drosophila melanogaster)
Insecta oys 35
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mboa-5 35
  • 17 (a)
ManyToMany
mboa-3 35
  • 15 (a)
ManyToMany
mboa-4 35
  • 15 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALE1 35
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10638 35
  • 19 (a)
OneToMany
Species where no ortholog for MBOAT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MBOAT4 Gene

ENSEMBL:
Gene Tree for MBOAT4 (if available)
TreeFam:
Gene Tree for MBOAT4 (if available)

Paralogs for MBOAT4 Gene

Paralogs for MBOAT4 Gene

genes like me logo Genes that share paralogs with MBOAT4: view

Variants for MBOAT4 Gene

Sequence variations from dbSNP and Humsavar for MBOAT4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000067962 -- 30,142,283(+) ATTGA(C/T)ATACA intron-variant
rs1000236346 -- 30,135,319(+) GGAAA(C/T)GTTGA intron-variant
rs1000533422 -- 30,138,158(+) AAATG(C/T)TCAGG intron-variant, downstream-variant-500B
rs1000579422 -- 30,133,400(+) TGAAT(A/G)TGTGT intron-variant
rs1000671656 -- 30,131,472(+) TTTAG(A/G)AAAAA intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MBOAT4 Gene

Variant ID Type Subtype PubMed ID
esv2736827 CNV deletion 23290073
esv3616784 CNV loss 21293372
nsv1124332 CNV deletion 24896259
nsv831277 CNV gain 17160897

Variation tolerance for MBOAT4 Gene

Gene Damage Index Score: 3.17; 51.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MBOAT4 Gene

Human Gene Mutation Database (HGMD)
MBOAT4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MBOAT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MBOAT4 Gene

Disorders for MBOAT4 Gene

Relevant External Links for MBOAT4

Human Genome Epidemiology (HuGE) Navigator
MBOAT4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MBOAT4

No disorders were found for MBOAT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MBOAT4 Gene

Publications for MBOAT4 Gene

  1. Ghrelin octanoylation mediated by an orphan lipid transferase. (PMID: 18443287) Gutierrez J.A. … Hale J.E. (Proc. Natl. Acad. Sci. U.S.A. 2008) 2 3 4 64
  2. Ghrelin O-acyltransferase (GOAT), a specific enzyme that modifies ghrelin with a medium-chain fatty acid. (PMID: 27489223) Kojima M. … Sato T. (J. Biochem. 2016) 3 64
  3. Structure-activity analysis of human ghrelin O-acyltransferase reveals chemical determinants of ghrelin selectivity and acyl group recognition. (PMID: 25562443) Darling J.E. … Hougland J.L. (Biochemistry 2015) 3 64
  4. Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight. (PMID: 24194510) Gahete M.D. … Luque R.M. (J. Endocrinol. 2014) 3 64
  5. The ghrelin activating enzyme ghrelin-O-acyltransferase (GOAT) is present in human plasma and expressed dependent on body mass index. (PMID: 23454172) Goebel-Stengel M. … Stengel A. (Peptides 2013) 3 64

Products for MBOAT4 Gene

Sources for MBOAT4 Gene

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