Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MBOAT2 Gene

Aliases for MBOAT2 Gene

  • Membrane Bound O-Acyltransferase Domain Containing 2 2 3
  • Membrane-Bound O-Acyltransferase Domain-Containing Protein 2 3 4
  • O-Acyltransferase (Membrane Bound) Domain Containing 2 2 3
  • 1-Acylglycerophosphoethanolamine O-Acyltransferase 3 4
  • O-Acyltransferase Domain-Containing Protein 2 3 4
  • Lysophosphatidylethanolamine Acyltransferase 3 4
  • 1-Acylglycerophosphate O-Acyltransferase 3 4
  • Lysophosphatidic Acid Acyltransferase 3 4
  • Lyso-PA Acyltransferase 3 4
  • Lyso-PE Acyltransferase 3 4
  • LPLAT 2 3 4
  • LPCAT4 3 6
  • OACT2 3 4
  • LPAAT 3 4
  • LPEAT 3 4
  • Lysophospholipid Acyltransferase 2 3
  • EC 2.3.1.51 4
  • EC 2.3.1.n7 4
  • EC 2.3.1.- 4

External Ids for MBOAT2 Gene

Previous HGNC Symbols for MBOAT2 Gene

  • OACT2

Previous GeneCards Identifiers for MBOAT2 Gene

  • GC02M008910
  • GC02M008996

Summaries for MBOAT2 Gene

GeneCards Summary for MBOAT2 Gene

MBOAT2 (Membrane Bound O-Acyltransferase Domain Containing 2) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is MBOAT7.

UniProtKB/Swiss-Prot for MBOAT2 Gene

  • Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBOAT2 Gene

Genomics for MBOAT2 Gene

Regulatory Elements for MBOAT2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MBOAT2 Gene

Start:
8,852,690 bp from pter
End:
9,003,813 bp from pter
Size:
151,124 bases
Orientation:
Minus strand

Genomic View for MBOAT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MBOAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MBOAT2 Gene

Proteins for MBOAT2 Gene

  • Protein details for MBOAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZWT7-MBOA2_HUMAN
    Recommended name:
    Lysophospholipid acyltransferase 2
    Protein Accession:
    Q6ZWT7
    Secondary Accessions:
    • A9EDR2
    • Q8NCE7
    • Q96KY4

    Protein attributes for MBOAT2 Gene

    Size:
    520 amino acids
    Molecular mass:
    59527 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11204.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MBOAT2 Gene

Proteomics data for MBOAT2 Gene at MOPED

Post-translational modifications for MBOAT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MBOAT2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MBOAT2 Gene

Domains for MBOAT2 Gene

Protein Domains for MBOAT2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MBOAT2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZWT7

UniProtKB/Swiss-Prot:

MBOA2_HUMAN :
  • Q6ZWT7
Family:
  • Belongs to the membrane-bound acyltransferase family.
genes like me logo Genes that share domains with MBOAT2: view

No data available for Gene Families for MBOAT2 Gene

Function for MBOAT2 Gene

Molecular function for MBOAT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine = CoA + 1,2-diacyl-sn-glycero-3-phosphoethanolamine
UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Partially inhibited by thimerosal
UniProtKB/Swiss-Prot Function: Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.

Enzyme Numbers (IUBMB) for MBOAT2 Gene

Gene Ontology (GO) - Molecular Function for MBOAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity IEA --
genes like me logo Genes that share ontologies with MBOAT2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MBOAT2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MBOAT2 Gene

Localization for MBOAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MBOAT2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MBOAT2 Gene COMPARTMENTS Subcellular localization image for MBOAT2 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MBOAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MBOAT2: view

Pathways for MBOAT2 Gene

genes like me logo Genes that share pathways with MBOAT2: view

UniProtKB/Swiss-Prot Q6ZWT7-MBOA2_HUMAN

  • Pathway: Lipid metabolism; phospholipid metabolism

Gene Ontology (GO) - Biological Process for MBOAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0036151 phosphatidylcholine acyl-chain remodeling TAS --
GO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0046474 glycerophospholipid biosynthetic process TAS --
genes like me logo Genes that share ontologies with MBOAT2: view

Transcripts for MBOAT2 Gene

Unigene Clusters for MBOAT2 Gene

Membrane bound O-acyltransferase domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MBOAT2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MBOAT2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MBOAT2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: - - -

Relevant External Links for MBOAT2 Gene

GeneLoc Exon Structure for
MBOAT2
ECgene alternative splicing isoforms for
MBOAT2

Expression for MBOAT2 Gene

mRNA expression in normal human tissues for MBOAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MBOAT2 Gene

SOURCE GeneReport for Unigene cluster for MBOAT2 Gene Hs.467634

mRNA Expression by UniProt/SwissProt for MBOAT2 Gene

Q6ZWT7-MBOA2_HUMAN
Tissue specificity: Expressed in neutrophils.
genes like me logo Genes that share expressions with MBOAT2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MBOAT2 Gene

Orthologs for MBOAT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MBOAT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MBOAT2 35
  • 99.42 (n)
  • 98.65 (a)
MBOAT2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MBOAT2 35
  • 88.48 (n)
  • 90.1 (a)
MBOAT2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MBOAT2 35
  • 89.47 (n)
  • 89.74 (a)
MBOAT2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mboat2 35
  • 85.68 (n)
  • 86.71 (a)
Mboat2 16
Mboat2 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MBOAT2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MBOAT2 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mboat2 35
  • 86.13 (n)
  • 87.28 (a)
chicken
(Gallus gallus)
Aves MBOAT2 35
  • 81.39 (n)
  • 82.45 (a)
MBOAT2 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MBOAT2 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mboat2 35
  • 71.41 (n)
  • 72.13 (a)
zebrafish
(Danio rerio)
Actinopterygii mboat2a 36
  • 64 (a)
OneToMany
mboat2b 35
  • 64.01 (n)
  • 65.13 (a)
mboat2b 36
  • 58 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007567 35
  • 47.36 (n)
  • 42.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta oys 35
  • 46.93 (n)
  • 41.8 (a)
oys 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mboa-3 36
  • 32 (a)
ManyToMany
mboa-4 35
  • 45.56 (n)
  • 37.41 (a)
mboa-4 36
  • 29 (a)
ManyToMany
mboa-5 36
  • 25 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR271C 35
  • 42.13 (n)
  • 30.87 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALE1 35
  • 45.1 (n)
  • 31.27 (a)
ALE1 36
  • 20 (a)
OneToMany
ALE1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20163g 35
  • 43.73 (n)
  • 31.47 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G63050 35
  • 44.62 (n)
  • 31.48 (a)
rice
(Oryza sativa)
Liliopsida Os02g0676000 35
  • 41.06 (n)
  • 28.29 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06194 35
  • 42.29 (n)
  • 31.21 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC16A3.10 35
  • 44.47 (n)
  • 31.19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10638 36
  • 32 (a)
OneToMany
Species with no ortholog for MBOAT2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MBOAT2 Gene

ENSEMBL:
Gene Tree for MBOAT2 (if available)
TreeFam:
Gene Tree for MBOAT2 (if available)

Paralogs for MBOAT2 Gene

Paralogs for MBOAT2 Gene

Selected SIMAP similar genes for MBOAT2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MBOAT2: view

Variants for MBOAT2 Gene

Sequence variations from dbSNP and Humsavar for MBOAT2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs722845 -- 8,932,790(+) ACATA(C/G)AAATC intron-variant
rs867457 -- 8,990,417(-) CTATA(A/G)TGCCA intron-variant
rs870250 -- 8,994,483(-) TGTAC(A/G)GCAGA intron-variant
rs967230 -- 8,998,724(+) TTTCT(C/G)TGTGT intron-variant
rs998967 -- 8,876,904(-) TAAAT(A/G)ACTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MBOAT2 Gene

Variant ID Type Subtype PubMed ID
nsv833359 CNV Loss 17160897
nsv517367 CNV Gain 19592680
esv2719616 CNV Deletion 23290073
nsv2600 CNV Insertion 18451855

Relevant External Links for MBOAT2 Gene

HapMap Linkage Disequilibrium report
MBOAT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MBOAT2 Gene

Disorders for MBOAT2 Gene

No disorders were found for MBOAT2 Gene.

No data available for UniProtKB/Swiss-Prot for MBOAT2 Gene

Publications for MBOAT2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  4. LPT1 encodes a membrane-bound O-acyltransferase involved in the acylation of lysophospholipids in the yeast Saccharomyces cerevisiae. (PMID: 17890783) Tamaki H. … Kumagai H. (J. Biol. Chem. 2007) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4

Products for MBOAT2 Gene

Sources for MBOAT2 Gene

Back to Top

Content