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Aliases for MBOAT2 Gene

Aliases for MBOAT2 Gene

  • Membrane Bound O-Acyltransferase Domain Containing 2 2 3 5
  • Membrane-Bound O-Acyltransferase Domain-Containing Protein 2 3 4
  • O-Acyltransferase (Membrane Bound) Domain Containing 2 2 3
  • 1-Acylglycerophosphoethanolamine O-Acyltransferase 3 4
  • Lysophosphatidylethanolamine Acyltransferase 3 4
  • 1-Acylglycerophosphate O-Acyltransferase 3 4
  • Lysophosphatidic Acid Acyltransferase 3 4
  • Lyso-PA Acyltransferase 3 4
  • Lyso-PE Acyltransferase 3 4
  • LPLAT 2 3 4
  • OACT2 3 4
  • LPAAT 3 4
  • LPEAT 3 4
  • O-Acyltransferase Domain-Containing Protein 2 4
  • Lysophospholipid Acyltransferase 2 3
  • EC 2.3.1.51 4
  • EC 2.3.1.n7 4
  • EC 2.3.1.- 4
  • LPCAT4 3

External Ids for MBOAT2 Gene

Previous HGNC Symbols for MBOAT2 Gene

  • OACT2

Previous GeneCards Identifiers for MBOAT2 Gene

  • GC02M008910
  • GC02M008996

Summaries for MBOAT2 Gene

GeneCards Summary for MBOAT2 Gene

MBOAT2 (Membrane Bound O-Acyltransferase Domain Containing 2) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is MBOAT1.

UniProtKB/Swiss-Prot for MBOAT2 Gene

  • Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBOAT2 Gene

Genomics for MBOAT2 Gene

Regulatory Elements for MBOAT2 Gene

Enhancers for MBOAT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F009033 0.2 Ensembl 11.6 -29.8 -29788 0.4 ARID1B JUND SMARCA4 IKZF1 MGA MBOAT2 HMGB1P25 RPL30P3
GH02F009060 0.2 ENCODE 11.2 -57.2 -57174 0.2 LEF1 ZNF175 ZNF644 CHAMP1 FOSL1 GATA2 ZNF584 TRIM24 ZNF639 L3MBTL2 MBOAT2 ENSG00000261104 RPL30P3 HMGB1P25
GH02F009052 0.4 Ensembl 11.2 -49.5 -49489 1.0 SCRT1 PKNOX1 MTA2 ARNT BMI1 SMARCA4 GATA2 IKZF1 SCRT2 MBOAT2 ENSG00000261104 RPL30P3 HMGB1P25
GH02F008957 0.2 Ensembl 11.2 +46.0 46013 0.4 KDM1A MBOAT2 PIR62426
GH02F009058 0.2 ENCODE 11.2 -54.4 -54364 0.2 KLF1 JUN KLF17 CHAMP1 HIC1 ZFHX2 ZNF316 CTBP1 ZNF366 TRIM24 MBOAT2 RPL30P3 HMGB1P25
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MBOAT2 on UCSC Golden Path with GeneCards custom track

Promoters for MBOAT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000584769 113 2601 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 ZNF2 ZNF143 ZNF207 FOS

Genomic Location for MBOAT2 Gene

Chromosome:
2
Start:
8,852,690 bp from pter
End:
9,003,813 bp from pter
Size:
151,124 bases
Orientation:
Minus strand

Genomic View for MBOAT2 Gene

Genes around MBOAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MBOAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MBOAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MBOAT2 Gene

Proteins for MBOAT2 Gene

  • Protein details for MBOAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZWT7-MBOA2_HUMAN
    Recommended name:
    Lysophospholipid acyltransferase 2
    Protein Accession:
    Q6ZWT7
    Secondary Accessions:
    • A9EDR2
    • Q8NCE7
    • Q96KY4

    Protein attributes for MBOAT2 Gene

    Size:
    520 amino acids
    Molecular mass:
    59527 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11204.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MBOAT2 Gene

Post-translational modifications for MBOAT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MBOAT2 Gene

Domains & Families for MBOAT2 Gene

Gene Families for MBOAT2 Gene

Protein Domains for MBOAT2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MBOAT2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZWT7

UniProtKB/Swiss-Prot:

MBOA2_HUMAN :
  • Belongs to the membrane-bound acyltransferase family.
Family:
  • Belongs to the membrane-bound acyltransferase family.
genes like me logo Genes that share domains with MBOAT2: view

Function for MBOAT2 Gene

Molecular function for MBOAT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine = CoA + 1,2-diacyl-sn-glycero-3-phosphoethanolamine.
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Partially inhibited by thimerosal.
UniProtKB/Swiss-Prot Function:
Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.

Enzyme Numbers (IUBMB) for MBOAT2 Gene

Gene Ontology (GO) - Molecular Function for MBOAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity TAS --
GO:0004147 dihydrolipoamide branched chain acyltransferase activity IEA --
GO:0008951 palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity IEA --
GO:0016406 carnitine O-acyltransferase activity IEA --
GO:0016412 serine O-acyltransferase activity IEA --
genes like me logo Genes that share ontologies with MBOAT2: view

Phenotypes for MBOAT2 Gene

GenomeRNAi human phenotypes for MBOAT2:
genes like me logo Genes that share phenotypes with MBOAT2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MBOAT2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MBOAT2 Gene

Localization for MBOAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MBOAT2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MBOAT2 Gene COMPARTMENTS Subcellular localization image for MBOAT2 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for MBOAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MBOAT2: view

Pathways & Interactions for MBOAT2 Gene

genes like me logo Genes that share pathways with MBOAT2: view

UniProtKB/Swiss-Prot Q6ZWT7-MBOA2_HUMAN

  • Pathway: Lipid metabolism; phospholipid metabolism.

Interacting Proteins for MBOAT2 Gene

Gene Ontology (GO) - Biological Process for MBOAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IEA --
GO:0008654 phospholipid biosynthetic process IEA --
GO:0036151 phosphatidylcholine acyl-chain remodeling TAS --
GO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS --
genes like me logo Genes that share ontologies with MBOAT2: view

No data available for SIGNOR curated interactions for MBOAT2 Gene

Drugs & Compounds for MBOAT2 Gene

(1) Drugs for MBOAT2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0
genes like me logo Genes that share compounds with MBOAT2: view

Transcripts for MBOAT2 Gene

Unigene Clusters for MBOAT2 Gene

Membrane bound O-acyltransferase domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MBOAT2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: - - -

Relevant External Links for MBOAT2 Gene

GeneLoc Exon Structure for
MBOAT2
ECgene alternative splicing isoforms for
MBOAT2

Expression for MBOAT2 Gene

mRNA expression in normal human tissues for MBOAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MBOAT2 Gene

This gene is overexpressed in Lung (23.7), Platelet (20.1), Peripheral blood mononuclear cells (9.8), and Breast (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MBOAT2 Gene



NURSA nuclear receptor signaling pathways regulating expression of MBOAT2 Gene:

MBOAT2

SOURCE GeneReport for Unigene cluster for MBOAT2 Gene:

Hs.467634

mRNA Expression by UniProt/SwissProt for MBOAT2 Gene:

Q6ZWT7-MBOA2_HUMAN
Tissue specificity: Expressed in neutrophils.
genes like me logo Genes that share expression patterns with MBOAT2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for MBOAT2 Gene

Orthologs for MBOAT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MBOAT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MBOAT2 34 35
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia MBOAT2 34 35
  • 89.47 (n)
cow
(Bos Taurus)
Mammalia MBOAT2 34 35
  • 88.48 (n)
rat
(Rattus norvegicus)
Mammalia Mboat2 34
  • 86.13 (n)
mouse
(Mus musculus)
Mammalia Mboat2 34 16 35
  • 85.68 (n)
oppossum
(Monodelphis domestica)
Mammalia MBOAT2 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MBOAT2 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves MBOAT2 34 35
  • 81.39 (n)
lizard
(Anolis carolinensis)
Reptilia MBOAT2 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mboat2 34
  • 71.41 (n)
zebrafish
(Danio rerio)
Actinopterygii mboat2b 34 35
  • 64.01 (n)
mboat2a 35
  • 64 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007567 34
  • 47.36 (n)
fruit fly
(Drosophila melanogaster)
Insecta oys 34 35
  • 46.93 (n)
worm
(Caenorhabditis elegans)
Secernentea mboa-4 34 35
  • 45.56 (n)
mboa-3 35
  • 32 (a)
ManyToMany
mboa-5 35
  • 25 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALE1 34 35 37
  • 45.1 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20163g 34
  • 43.73 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR271C 34
  • 42.13 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G63050 34
  • 44.62 (n)
rice
(Oryza sativa)
Liliopsida Os02g0676000 34
  • 41.06 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC16A3.10 34
  • 44.47 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06194 34
  • 42.29 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10638 35
  • 32 (a)
OneToMany
Species where no ortholog for MBOAT2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MBOAT2 Gene

ENSEMBL:
Gene Tree for MBOAT2 (if available)
TreeFam:
Gene Tree for MBOAT2 (if available)

Paralogs for MBOAT2 Gene

Paralogs for MBOAT2 Gene

(1) SIMAP similar genes for MBOAT2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MBOAT2: view

Variants for MBOAT2 Gene

Sequence variations from dbSNP and Humsavar for MBOAT2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10164871 -- 8,853,212(+) TCGTG(C/T)CCCTT nc-transcript-variant, utr-variant-3-prime
rs10165076 -- 8,913,585(+) cccaa(A/C)atcac intron-variant
rs10170080 -- 8,945,726(+) GAAAA(G/T)GAAAC intron-variant
rs10175544 -- 8,904,392(+) ctgca(A/G)cctca intron-variant
rs10177181 -- 8,913,403(+) aaccc(A/G)cagag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MBOAT2 Gene

Variant ID Type Subtype PubMed ID
esv2719616 CNV deletion 23290073
esv3589761 CNV loss 21293372
nsv1071970 CNV deletion 25765185
nsv1112756 CNV deletion 24896259
nsv2600 CNV insertion 18451855
nsv517367 CNV gain 19592680
nsv833359 CNV loss 17160897

Variation tolerance for MBOAT2 Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MBOAT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MBOAT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MBOAT2 Gene

Disorders for MBOAT2 Gene

Relevant External Links for MBOAT2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MBOAT2

No disorders were found for MBOAT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MBOAT2 Gene

Publications for MBOAT2 Gene

  1. LPT1 encodes a membrane-bound O-acyltransferase involved in the acylation of lysophospholipids in the yeast Saccharomyces cerevisiae. (PMID: 17890783) Tamaki H. … Kumagai H. (J. Biol. Chem. 2007) 3 4 64
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64

Products for MBOAT2 Gene

Sources for MBOAT2 Gene

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