Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MBOAT2 Gene

protein-coding   GIFtS: 50
GCID: GC02M008910

Membrane Bound O-Acyltransferase Domain Containing 2

(Previous name: O-acyltransferase (membrane bound) domain containing 2)
(Previous symbol: OACT2)
  Search for MBOAT2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Membrane Bound O-Acyltransferase Domain Containing 21 2     LPAAT2 3
OACT21 2 3     LPEAT2 3
O-Acyltransferase (Membrane Bound) Domain Containing 21 2     LPLAT 22 3
Lyso-PA Acyltransferase2 3     O-Acyltransferase Domain-Containing Protein 22 3
Lyso-PE Acyltransferase2 3     LPCAT42 5
Lysophosphatidic Acid Acyltransferase2 3     Lysophospholipid Acyltransferase 22
Lysophosphatidylethanolamine Acyltransferase2 3     EC 2.3.1.-3
Membrane-Bound O-Acyltransferase Domain-Containing Protein 22 3     EC 2.3.1.513
1-Acylglycerophosphate O-Acyltransferase2 3     EC 2.3.1.n73
1-Acylglycerophosphoethanolamine O-Acyltransferase2 3     

External Ids:    HGNC: 251931   Entrez Gene: 1296422   Ensembl: ENSG000001437977   OMIM: 6119495   UniProtKB: Q6ZWT73   

Export aliases for MBOAT2 gene to outside databases

Previous GC identifer: GC02M008843


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MBOAT2 Gene: 
MBOAT2 (membrane bound O-acyltransferase domain containing 2) is a protein-coding gene. Among its related super-pathways are Glycerophospholipid biosynthesis and Metabolic pathways. GO annotations related to this gene include 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is LPCAT3.

UniProtKB/Swiss-Prot: MBOA2_HUMAN, Q6ZWT7
Function: Acyltransferase which mediates the conversion of lysophosphatidylethanolamine
(1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine
(1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of
lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak
lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid
acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the
Lands cycle




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005334.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MBOAT2 gene promoter:
         HFH-3   USF1   Sox5   Nkx2-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   FOXI1   RORalpha1   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMBOAT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MBOAT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MBOAT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.1   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p25

MBOAT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MBOAT2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M008910:  view genomic region     (about GC identifiers)

Start:
8,992,820 bp from pter      End:
9,143,942 bp from pter
Size:
151,123 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MBOA2_HUMAN, Q6ZWT7 (See protein sequence)
Recommended Name: Lysophospholipid acyltransferase 2  
Size: 520 amino acids; 59527 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAC11204.1; Type=Erroneous initiation;
Secondary accessions: A9EDR2 Q8NCE7 Q96KY4

Explore the universe of human proteins at neXtProt for MBOAT2: NX_Q6ZWT7

Explore proteomics data for MBOAT2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZWT7

  • MBOAT2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MBOAT2 Protein Expression
    REFSEQ proteins: NP_620154.2  
    ENSEMBL proteins: 
     ENSP00000302177   ENSP00000419573   ENSP00000420114   ENSP00000417409  
    Reactome Protein details: Q6ZWT7
    Human Recombinant Protein Products for MBOAT2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MBOAT2
    GenScript Custom Purified and Recombinant Proteins Services for MBOAT2
    Novus Biologicals MBOAT2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MBOAT2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral to membrane IEA--

    MBOAT2 for ontologies           About GeneDecksing



    MBOAT2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MBOAT2
    GenScript Custom Superior Antibodies Services for MBOAT2
    Novus Biologicals MBOAT2 Antibody
    Abcam antibodies for MBOAT2
    Cloud-Clone Corp. Antibodies for MBOAT2 
    Search ThermoFisher Antibodies for MBOAT2
    LSBio Antibodies in human, mouse, rat for MBOAT2 

    Assay Products for MBOAT2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MBOAT2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MBOAT2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MBOAT2 
    Cloud-Clone Corp. CLIAs for MBOAT2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR004299 MBOAT_fam

    Graphical View of Domain Structure for InterPro Entry Q6ZWT7

    ProtoNet protein and cluster: Q6ZWT7

    UniProtKB/Swiss-Prot: MBOA2_HUMAN, Q6ZWT7
    Similarity: Belongs to the membrane-bound acyltransferase family


    MBOAT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MBOA2_HUMAN, Q6ZWT7
    Function: Acyltransferase which mediates the conversion of lysophosphatidylethanolamine
    (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine
    (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of
    lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak
    lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid
    acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the
    Lands cycle
    Catalytic activity: Acyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine = CoA +
    1,2-diacyl-sn-glycero-3-phosphoethanolamine
    Catalytic activity: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate
    Enzyme regulation: Partially inhibited by thimerosal

         Enzyme Numbers (IUBMB): EC 2.3.1.n71 EC 2.3.1.511 EC 2.3.1.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity IEA--
         
    MBOAT2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MBOAT2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MBOAT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MBOAT2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MBOAT2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MBOAT2
    8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate MBOAT2 (see all 61):
    hsa-miR-579 hsa-miR-4291 hsa-miR-607 hsa-miR-429 hsa-miR-25 hsa-miR-3653 hsa-miR-877* hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidMBOAT2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MBOAT2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MBOAT2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MBOAT2
    Sirion Biotech Customized adenovirus for overexpression of MBOAT2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MBOAT2 (see all 5)
    OriGene ORF clones in mouse, rat for MBOAT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MBOAT2 (NM_138799)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MBOAT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MBOAT2
    Sirion Biotech Customized lentivirus for stable overexpression of MBOAT2 
                         Customized lentivirus expression plasmids for stable overexpression of MBOAT2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MBOAT2
    Search LifeMap BioReagents cell lines for MBOAT2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MBOAT2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MBOAT2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Glycerophospholipid metabolism0.62
    Phospholipid metabolism0.64
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    3CDP-diacylglycerol biosynthesis I
    CDP-diacylglycerol biosynthesis I0.94
    triacylglycerol biosynthesis0.50
    phosphatidylglycerol biosynthesis II (non-plastidic)0.94
    4Acyl chain remodelling of PE
    Acyl chain remodelling of PE0.85
    Acyl chain remodelling of PC0.85
    5Glycerolipid metabolism
    Glycerolipid metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for MBOAT2
        CDP-diacylglycerol biosynthesis I
    triacylglycerol biosynthesis
    phosphatidylglycerol biosynthesis II (non-plastidic)

    5/6        Reactome Pathways for MBOAT2 (see all 6)
        Acyl chain remodelling of PE
    Glycerophospholipid biosynthesis
    Metabolism
    Acyl chain remodelling of PC
    Phospholipid metabolism


    3         Kegg Pathways  (Kegg details for MBOAT2):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: MBOA2_HUMAN, Q6ZWT7
    Pathway: Lipid metabolism; phospholipid metabolism


    MBOAT2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MBOAT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/60 Interacting proteins for MBOAT2 (Q6ZWT73 ENSP000003021774) via UniProtKB, MINT, STRING, and/or I2D (see all 60)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGPAT1Q999433I2D: score=1 
    ENSG00000206324Q999433I2D: score=1 
    ENSG00000226467Q999433I2D: score=1 
    ENSG00000227642Q999433I2D: score=1 
    ENSG00000228892Q999433I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0036151phosphatidylcholine acyl-chain remodeling TAS--
    GO:0036152phosphatidylethanolamine acyl-chain remodeling TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0046474glycerophospholipid biosynthetic process TAS--

    MBOAT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MBOAT2 (MBOA2)

    Search CenterWatch for drugs/clinical trials and news about MBOAT2 / MBOA2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MBOAT2 gene: 
    NM_138799.2  

    Unigene Clusters for MBOAT2:

    Membrane bound O-acyltransferase domain containing 2
    Hs.467634  [show with all ESTs], Hs.593538  [show with all ESTs]
    Unigene Representative Sequences: NM_138799, AF052107
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305997(uc002qzg.1 uc010yix.1) ENST00000471753 ENST00000486315
    ENST00000473432 ENST00000486484 ENST00000494760 ENST00000477073 ENST00000474341
    ENST00000462696 ENST00000460786
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MBOAT2
    8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate MBOAT2 (see all 61):
    hsa-miR-579 hsa-miR-4291 hsa-miR-607 hsa-miR-429 hsa-miR-25 hsa-miR-3653 hsa-miR-877* hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidMBOAT2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MBOAT2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MBOAT2
    Clone
    Products:
         
    OriGene clones in human, mouse for MBOAT2 (see all 5)
    OriGene ORF clones in mouse, rat for MBOAT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MBOAT2 (NM_138799)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MBOAT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MBOAT2
    Sirion Biotech Customized lentivirus for stable overexpression of MBOAT2 
                         Customized lentivirus expression plasmids for stable overexpression of MBOAT2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MBOAT2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MBOAT2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MBOAT2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MBOAT2

    Additional mRNA sequence: AF052107.1 

    14 DOTS entries:

    DT.97760554  DT.114404  DT.100044364  DT.441494  DT.120965098  DT.40240092  DT.91887369  DT.120965086 
    DT.120965102  DT.100888874  DT.95356882  DT.120965077  DT.91817896  DT.100703505 

    24/118 AceView cDNA sequences (see all 118):

    AA789002 NM_138799 AI040666 AA449282 W60959 AK074779 AA332287 AW188870 
    H61476 AL118923 AI925869 BM693872 AA581966 BE646183 BQ448055 AK027321 
    BF114614 BU624589 AI951970 AA347970 AA347969 W63789 BM823666 CF122771 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MBOAT2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                                                                    
    SP2:              -     -     -                                                         


    ECgene alternative splicing isoforms for MBOAT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MBOAT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGAAATGG
    MBOAT2 Expression
    About this image


    See MBOAT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MBOAT2

    SOURCE GeneReport for Unigene clusters: Hs.467634 Hs.593538

    UniProtKB/Swiss-Prot: MBOA2_HUMAN, Q6ZWT7
    Tissue specificity: Expressed in neutrophils

        SABiosciences Custom PCR Arrays for MBOAT2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MBOAT2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MBOAT2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MBOAT2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MBOAT2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MBOAT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MBOAT2 gene from 9/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mboat21 , 5 membrane bound O-acyltransferase domain containing more1, 5 85.68(n)1
    86.71(a)1
      12 (8.50 cM)5
    672161  NM_026037.31  NP_080313.21 
     248315995 
    chicken
    (Gallus gallus)
    Aves MBOAT21 membrane bound O-acyltransferase domain containing more 81.59(n)
    82.75(a)
      421925  NM_001031090.1  NP_001026261.1 
    lizard
    (Anolis carolinensis)
    Reptilia MBOAT26
    Uncharacterized protein
    78(a)
    1 ↔ 1
    1(148747709-148873413)
    zebrafish
    (Danio rerio)
    Actinopterygii BI710672.12   -- 77.31(n)    BI710672.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta oys1 oysgedart 46.73(n)
    40.59(a)
      36045  NM_136702.2  NP_610546.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mboa-41 Protein MBOA-4 45.37(n)
    36.81(a)
      182414  NM_069690.1  NP_502091.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ALE1(YOR175C)4
    ALE11
    Broad-specificity lysophospholipid acyltransferase, more4
    Ale1p1
    44.98(n)1
    31.47(a)1
      15(661674-659815)4
    8543461, 4  NP_014818.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G630501 membrane bound O-acyl transferase domain-containing more 43.95(n)
    31.11(a)
      842608  NM_104983.4  NP_176493.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g06760001 hypothetical protein 41.67(n)
    28.7(a)
      4330302  NM_001054258.1  NP_001047723.1 


    ENSEMBL Gene Tree for MBOAT2 (if available)
    TreeFam Gene Tree for MBOAT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MBOAT2 gene
    LPCAT32  MBOAT42  MBOAT12  MBOAT72  
    1 SIMAP similar gene for MBOAT2 using alignment to 4 protein entries:     MBOA2_HUMAN (see all proteins):
    MBOAT1

    MBOAT2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2467 SNPs in MBOAT2 are shown (see all 2467)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880916321,2
    --8968468(+) CAGGGG/TTATGA 1 -- ds50010--------
    rs1484132611,2
    C--8968478(+) AAATC-/AAGTCA 1 -- ds50010--------
    rs15502561,2
    C,F,A,H--8968561(-) ATGATC/TTTGGC 1 -- ds50019Minor allele frequency- T:0.12NS EA NA WA 646
    rs15502551,2
    C,F,O,A,H--8968564(-) AATATG/AATCTT 1 -- ds500120Minor allele frequency- A:0.28NS EA NA WA CSA 2344
    rs1130021771,2
    C,F--8968615(+) GCTGAG/TAAATA 1 -- ds50012Minor allele frequency- T:0.05CSA WA 120
    rs1411260631,2
    --8968676(+) CAAAA-/CACAAAAA 1 -- cds10--------
    rs605964321,2
    C--8968679(+) AAAAA-/C/    
       CACAC
    AACAC
    1 -- ds50010--------
    rs347467381,2
    C--8968680(+) AAAAA-/C/CAC 
            
    ACACA
    2 -- ds5001 cds10--------
    rs15502541,2
    C,F,A--8968966(-) CAGCCC/TGGGTG 1 -- ut31 ese34Minor allele frequency- T:0.33MN NA 190
    rs133880061,2
    C,F,A--8968984(+) GTGGCA/GCAATT 1 -- ut31 ese34Minor allele frequency- G:0.38NA WA 8

    HapMap Linkage Disequilibrium report for MBOAT2 (8992820 - 9143942 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MBOAT2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2719616CNV Deletion23290073
    nsv2600CNV Insertion18451855
    nsv833359CNV Loss17160897
    nsv517367CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MBOAT2
    DNA2.0 Custom Variant and Variant Library Synthesis for MBOAT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MBOAT2 for disorders           About MalaCards
    OMIM gene information: 611949    OMIM disorders: --


    MBOAT2 for disorders           About GeneDecksing


    Export disorders for MBOAT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MBOAT2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MBOAT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. LPT1 encodes a membrane-bound O-acyltransferase involved in the acylation of lysophospholipids in the yeast Saccharomyces cerevisiae. (PubMed id 17890783)1, 2 Tamaki H.... Kumagai H. (2007)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils. (PubMed id 18772128)2 Gijon M.A.... Voelker D.R. (2008)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)
    9. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 129642 HGNC: 25193 AceView: OACT2 Ensembl:ENSG00000143797 euGenes: HUgn129642
    ECgene: MBOAT2 Kegg: 129642 H-InvDB: MBOAT2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MBOAT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MBOAT2 gene:
    Search GeneIP for patents involving MBOAT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MBOAT2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MBOAT2  
     OriGene qSTAR qPCR primer pairs in human, mouse for MBOAT2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MBOAT2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MBOAT2   OriGene Custom Protein Services for MBOAT2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MBOAT2
     QIAGEN SeqTarget long-range PCR primers for resequencing MBOAT2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MBOAT2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MBOAT2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MBOAT2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MBOAT2
     GenScript Custom Purified and Recombinant Proteins Services for MBOAT2 GenScript cDNA clones with any tag delivered in your preferred vector for MBOAT2
     GenScript Custom Assay Services for MBOAT2 GenScript Custom Superior Antibodies Services for MBOAT2
     GenScript Custom overexpressing Cell Line Services for MBOAT2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MBOAT2 promoter
     Search Chromatin IP Primers for MBOAT2
     RT2 qPCR Primer Assay in human, mouse, rat MBOAT2
     Search GNC Networks for MBOAT2
     SABiosciences Custom PCR Arrays for MBOAT2
     Search Tocris compounds for MBOAT2 (MBOA2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MBOAT2 antibodies
     MBOAT2 proteins
     Antibodies for MBOAT2
     See all of Abcam's Antibodies, Kits and Proteins for MBOAT2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for MBOAT2
     Antibodies for MBOAT2
     ELISAs for MBOAT2
     CLIAs for MBOAT2
     Search LifeMap BioReagents cell lines for MBOAT2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MBOAT2
     SwitchGear 3'UTR luciferase reporter plasmids for MBOAT2
     SwitchGear Promoter luciferase reporter plasmids for MBOAT2
     Search ThermoFisher Antibodies for MBOAT2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MBOAT2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MBOAT2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MBOAT2
    Customized:
     lentivirus for stable overexpression of MBOAT2
     lentivirus expression plasmids for stable overexpression of MBOAT2
     adenovirus for overexpression of MBOAT2
     LSBio Antibodies in human, mouse, rat for MBOAT2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MBOAT2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4