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MBOAT2 Gene

protein-coding   GIFtS: 51
GCID: GC02M008996

Membrane Bound O-Acyltransferase Domain Containing 2

(Previous name: O-acyltransferase (membrane bound) domain containing 2)
(Previous symbol: OACT2)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Membrane Bound O-Acyltransferase Domain Containing 21 2     LPAAT2 3
OACT21 2 3     LPEAT2 3
O-Acyltransferase (Membrane Bound) Domain Containing 21 2     LPLAT 22 3
Lyso-PA Acyltransferase2 3     O-Acyltransferase Domain-Containing Protein 22 3
Lyso-PE Acyltransferase2 3     LPCAT42 5
Lysophosphatidic Acid Acyltransferase2 3     Lysophospholipid Acyltransferase 22
Lysophosphatidylethanolamine Acyltransferase2 3     EC 2.3.1.-3
Membrane-Bound O-Acyltransferase Domain-Containing Protein 22 3     EC 2.3.1.513
1-Acylglycerophosphate O-Acyltransferase2 3     EC 2.3.1.n73
1-Acylglycerophosphoethanolamine O-Acyltransferase2 3     

External Ids:    HGNC: 251931   Entrez Gene: 1296422   Ensembl: ENSG000001437977   OMIM: 6119495   UniProtKB: Q6ZWT73   

Export aliases for MBOAT2 gene to outside databases

Previous GC identifers: GC02M008910 GC02M008843


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MBOAT2 Gene:
MBOAT2 (membrane bound O-acyltransferase domain containing 2) is a protein-coding gene. Diseases associated with MBOAT2 include malaria. GO annotations related to this gene include 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is LPCAT3.

UniProtKB/Swiss-Prot: MBOA2_HUMAN, Q6ZWT7
Function: Acyltransferase which mediates the conversion of lysophosphatidylethanolamine
(1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine
(1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of
lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak
lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid
acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the
Lands cycle




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005334.17  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MBOAT2 gene promoter:
         HFH-3   USF1   Sox5   Nkx2-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   FOXI1   RORalpha1   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMBOAT2 promoter sequence
   Search Chromatin IP Primers for MBOAT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MBOAT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.1   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p25

MBOAT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MBOAT2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M008996:  view genomic region     (about GC identifiers)

Start:
8,992,820 bp from pter      End:
9,143,942 bp from pter
Size:
151,123 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MBOA2_HUMAN, Q6ZWT7 (See protein sequence)
Recommended Name: Lysophospholipid acyltransferase 2  
Size: 520 amino acids; 59527 Da
Sequence caution: Sequence=BAC11204.1; Type=Erroneous initiation;
Secondary accessions: A9EDR2 Q8NCE7 Q96KY4

Explore the universe of human proteins at neXtProt for MBOAT2: NX_Q6ZWT7

Explore proteomics data for MBOAT2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MBOAT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_620154.2  
    ENSEMBL proteins: 
     ENSP00000302177   ENSP00000419573   ENSP00000420114   ENSP00000417409  
    Reactome Protein details: Q6ZWT7

    MBOAT2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004299 MBOAT_fam

    Graphical View of Domain Structure for InterPro Entry Q6ZWT7

    ProtoNet protein and cluster: Q6ZWT7

    UniProtKB/Swiss-Prot: MBOA2_HUMAN, Q6ZWT7
    Similarity: Belongs to the membrane-bound acyltransferase family


    MBOAT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MBOA2_HUMAN, Q6ZWT7
    Function: Acyltransferase which mediates the conversion of lysophosphatidylethanolamine
    (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine
    (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of
    lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak
    lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid
    acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the
    Lands cycle
    Catalytic activity: Acyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine = CoA +
    1,2-diacyl-sn-glycero-3-phosphoethanolamine
    Catalytic activity: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate
    Enzyme regulation: Partially inhibited by thimerosal

         Enzyme Numbers (IUBMB): EC 2.3.1.n71 EC 2.3.1.511 EC 2.3.1.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity IEA--
         
    MBOAT2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MBOAT2
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    hsa-miR-579 hsa-miR-4291 hsa-miR-607 hsa-miR-429 hsa-miR-25 hsa-miR-3653 hsa-miR-877* hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidMBOAT2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MBOA2_HUMAN, Q6ZWT7: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    plasma membrane3
    cytosol1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--

    MBOAT2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MBOAT2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Glycerophospholipid metabolism0.62
    Phospholipid metabolism0.64
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3triacylglycerol biosynthesis
    triacylglycerol biosynthesis0.48
    CDP-diacylglycerol biosynthesis I0.00
    phosphatidylglycerol biosynthesis II (non-plastidic)0.48
    4Acyl chain remodelling of PC
    Acyl chain remodelling of PE0.85
    Acyl chain remodelling of PC0.85
    5Glycerolipid metabolism
    Glycerolipid metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for MBOAT2
        CDP-diacylglycerol biosynthesis I
    triacylglycerol biosynthesis
    phosphatidylglycerol biosynthesis II (non-plastidic)

    2 Reactome Pathways for MBOAT2
        Acyl chain remodelling of PE
    Acyl chain remodelling of PC


    3 Kegg Pathways  (Kegg details for MBOAT2):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: MBOA2_HUMAN, Q6ZWT7
    Pathway: Lipid metabolism; phospholipid metabolism


    MBOAT2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MBOAT2
    Interactions:

        Search GeneGlobe Interaction Network for MBOAT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MBOAT2 (Q6ZWT73 ENSP000003021774) via UniProtKB, MINT, STRING, and/or I2D (see all 68)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGPAT1Q999433, ENSP000003374634I2D: score=1 STRING: ENSP00000337463
    ENSG00000206324Q999433, ENSP000003827234I2D: score=1 STRING: ENSP00000382723
    ENSG00000226467Q999433, ENSP000004058644I2D: score=1 STRING: ENSP00000405864
    ENSG00000227642Q999433, ENSP000003895164I2D: score=1 STRING: ENSP00000389516
    ENSG00000228892Q999433, ENSP000004128054I2D: score=1 STRING: ENSP00000412805
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0036151phosphatidylcholine acyl-chain remodeling TAS--
    GO:0036152phosphatidylethanolamine acyl-chain remodeling TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0046474glycerophospholipid biosynthetic process TAS--

    MBOAT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MBOAT2 (MBOA2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MBOAT2 gene: 
    NM_138799.2  

    Unigene Clusters for MBOAT2:

    Membrane bound O-acyltransferase domain containing 2
    Hs.467634  [show with all ESTs], Hs.593538  [show with all ESTs]
    Unigene Representative Sequences: NM_138799, AF052107
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305997(uc002qzg.1 uc010yix.1) ENST00000471753 ENST00000486315
    ENST00000473432 ENST00000486484 ENST00000494760 ENST00000477073 ENST00000474341
    ENST00000462696 ENST00000460786
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MBOAT2 (see all 61):
    hsa-miR-579 hsa-miR-4291 hsa-miR-607 hsa-miR-429 hsa-miR-25 hsa-miR-3653 hsa-miR-877* hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidMBOAT2 3' UTR sequence
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    Additional mRNA sequence: AF052107.1 

    14 DOTS entries:

    DT.97760554  DT.114404  DT.100044364  DT.441494  DT.120965098  DT.40240092  DT.91887369  DT.120965086 
    DT.120965102  DT.100888874  DT.95356882  DT.120965077  DT.91817896  DT.100703505 

    Selected AceView cDNA sequences (see all 118):

    AA449282 AA332287 AI925869 NM_138799 W60959 AI040666 BM693872 H61476 
    AL118923 AA789002 AW188870 AK074779 BU624589 W63676 BM670934 BF114614 
    AI951970 AA347970 CF122771 BQ448055 AI690750 BM126251 AI139947 CF528456 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MBOAT2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                                                                    
    SP2:              -     -     -                                                         


    ECgene alternative splicing isoforms for MBOAT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MBOAT2 expression in normal human tissues (normalized intensities)      MBOAT2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGAAATGG
    MBOAT2 Expression
    About this image


    MBOAT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Esophagus (Gastrointestinal Tract)
    MBOAT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MBOAT2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.467634 Hs.593538

    UniProtKB/Swiss-Prot: MBOA2_HUMAN, Q6ZWT7
    Tissue specificity: Expressed in neutrophils

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MBOAT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MBOAT2 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mboat21 , 5 membrane bound O-acyltransferase domain containing more1, 5 85.68(n)1
    86.71(a)1
      12 (8.50 cM)5
    672161  NM_026037.31  NP_080313.21 
     248315995 
    chicken
    (Gallus gallus)
    Aves MBOAT21 membrane bound O-acyltransferase domain containing more 81.39(n)
    82.45(a)
      421925  NM_001031090.1  NP_001026261.1 
    lizard
    (Anolis carolinensis)
    Reptilia MBOAT26
    membrane bound O-acyltransferase domain containing...
    78(a)
    1 ↔ 1
    1(148747709-148873413)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mboat21 membrane bound O-acyltransferase domain containing more 71.41(n)
    72.13(a)
      100124655  NM_001102685.1  NP_001096155.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI710672.12   -- 77.31(n)    BI710672.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta oys1 oysgedart 46.93(n)
    41.8(a)
      36045  NM_136702.2  NP_610546.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mboa-41 mboa-4 45.56(n)
    37.41(a)
      182414  NM_001268615.1  NP_001255544.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ALE1(YOR175C)4
    ALE11
    Broad-specificity lysophospholipid acyltransferase, more4
    ALE11
    45.1(n)1
    31.27(a)1
      15(661674-659815)4
    8543461, 4  NP_014818.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G630501 AT1G63050 44.62(n)
    31.48(a)
      842608  NM_104983.4  NP_176493.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g06760001 Os02g0676000 41.06(n)
    28.29(a)
      4330302  NM_001054258.1  NP_001047723.1 


    ENSEMBL Gene Tree for MBOAT2 (if available)
    TreeFam Gene Tree for MBOAT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MBOAT2 gene
    LPCAT32  MBOAT42  MBOAT12  MBOAT72  
    1 SIMAP similar gene for MBOAT2 using alignment to 4 protein entries:     MBOA2_HUMAN (see all proteins):
    MBOAT1

    MBOAT2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MBOAT2 (see all 2467)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880916321,2
    --8968468(+) CAGGGG/TTATGA 1 -- ds50010--------
    rs1484132611,2
    C--8968478(+) AAATC-/AAGTCA 1 -- ds50010--------
    rs15502561,2
    C,F,A,H--8968561(-) ATGATC/TTTGGC 1 -- ds50019Minor allele frequency- T:0.12NS EA NA WA 646
    rs15502551,2
    C,F,O,A,H--8968564(-) AATATG/AATCTT 1 -- ds500120Minor allele frequency- A:0.28NS EA NA WA CSA 2344
    rs1130021771,2
    C,F--8968615(+) GCTGAG/TAAATA 1 -- ds50012Minor allele frequency- T:0.05CSA WA 120
    rs1411260631,2
    --8968676(+) CAAAA-/CACAAAAA 1 -- cds10--------
    rs605964321,2
    C--8968679(+) AAAAA-/C/    
       CACAC
    AACAC
    1 -- ds50010--------
    rs347467381,2
    C--8968680(+) AAAAA-/C/CAC 
            
    ACACA
    2 -- ds5001 cds10--------
    rs15502541,2
    C,F,A--8968966(-) CAGCCC/TGGGTG 1 -- ut31 ese34Minor allele frequency- T:0.33MN NA 190
    rs133880061,2
    C,F,A--8968984(+) GTGGCA/GCAATT 1 -- ut31 ese34Minor allele frequency- G:0.38NA WA 8

    HapMap Linkage Disequilibrium report for MBOAT2 (8992820 - 9143942 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MBOAT2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719616CNV Deletion23290073
    nsv2600CNV Insertion18451855
    nsv833359CNV Loss17160897
    nsv517367CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611949    OMIM disorders: --

    1 disease for MBOAT2:    About MalaCards
    malaria


    MBOAT2 for disorders           About GeneDecksing


    Export disorders for MBOAT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MBOAT2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MBOAT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. LPT1 encodes a membrane-bound O-acyltransferase involved in the acylation of lysophospholipids in the yeast Saccharomyces cerevisiae. (PubMed id 17890783)1, 2 Tamaki H.... Kumagai H. (J. Biol. Chem. 2007)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils. (PubMed id 18772128)2 Gijon M.A.... Voelker D.R. (J. Biol. Chem. 2008)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (Genome Res. 1997)
    9. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 129642 HGNC: 25193 AceView: OACT2 Ensembl:ENSG00000143797 euGenes: HUgn129642
    ECgene: MBOAT2 Kegg: 129642 H-InvDB: MBOAT2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MBOAT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MBOAT2 gene:
    Search GeneIP for patents involving MBOAT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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