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MBOAT1 Gene

protein-coding   GIFtS: 49
GCID: GC06M020102

Membrane Bound O-Acyltransferase Domain Containing 1

(Previous name: O-acyltransferase (membrane bound) domain containing 1)
(Previous symbol: OACT1)
  See MBOAT1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Membrane Bound O-Acyltransferase Domain Containing 11 2     LPLAT 12 3
OACT11 2 3     O-Acyltransferase Domain-Containing Protein 12 3
O-Acyltransferase (Membrane Bound) Domain Containing 11 2     12
Lysophosphatidylethanolamine Acyltransferase 11 2     LPEAT12
Lyso-PS Acyltransferase2 3     LPLAT2
Lysophosphatidylserine Acyltransferase2 3     dJ434O11.12
Membrane-Bound O-Acyltransferase Domain-Containing Protein 12 3     Lysophospholipid Acyltransferase 12
1-Acylglycerophosphoserine O-Acyltransferase2 3     EC 2.3.1.-3
LPSAT2 3     EC 2.3.1.n63

External Ids:    HGNC: 215791   Entrez Gene: 1541412   Ensembl: ENSG000001721977   OMIM: 6117325   UniProtKB: Q6ZNC83   

Export aliases for MBOAT1 gene to outside databases

Previous GC identifer: GC06M020209


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MBOAT1 Gene:
This gene belongs to the membrane-bound O-acetyltransferase superfamily. The encoded transmembrane protein is an
enzyme that transfers organic compounds, preferably from oleoyl-CoA, to hydroxyl groups of protein targets in
membranes. A translocation disrupting this gene may be associated with brachydactyly syndactyly syndrome.
Alternately spliced transcript variants have been described for this gene. (provided by RefSeq, Nov 2012)

GeneCards Summary for MBOAT1 Gene:
MBOAT1 (membrane bound O-acyltransferase domain containing 1) is a protein-coding gene. Diseases associated with MBOAT1 include brachydactyly-syndactyly syndrome. GO annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups. An important paralog of this gene is LPCAT3.

UniProtKB/Swiss-Prot: MBOA1_HUMAN, Q6ZNC8
Function: Acyltransferase which mediates the conversion of lysophosphatidylserine
(1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine
(1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Prefers oleoyl-CoA as the acyl donor.
Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway
also known as the Lands cycle




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MBOAT1 gene promoter:
         MEF-2   MEF-2A   POU2F1   POU2F1b   POU2F1a   FOXO4   FOXO1a   STAT3   POU2F1c   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MBOAT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MBOAT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p22.3

MBOAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MBOAT1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M020102:  view genomic region     (about GC identifiers)

Start:
20,100,935 bp from pter      End:
20,212,670 bp from pter
Size:
111,736 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MBOA1_HUMAN, Q6ZNC8 (See protein sequence)
Recommended Name: Lysophospholipid acyltransferase 1  
Size: 495 amino acids; 56557 Da
Secondary accessions: A9EDQ5 B4DL59 B4E3J4 Q86XC2 Q8N9R5
Alternative splicing: 3 isoforms:  Q6ZNC8-1   Q6ZNC8-2   Q6ZNC8-3   

Explore the universe of human proteins at neXtProt for MBOAT1: NX_Q6ZNC8

Explore proteomics data for MBOAT1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MBOAT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073949.1  
    ENSEMBL proteins: 
     ENSP00000324944   ENSP00000441568   ENSP00000439814  
    Reactome Protein details: Q6ZNC8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004299 MBOAT_fam

    Graphical View of Domain Structure for InterPro Entry Q6ZNC8

    ProtoNet protein and cluster: Q6ZNC8

    UniProtKB/Swiss-Prot: MBOA1_HUMAN, Q6ZNC8
    Similarity: Belongs to the membrane-bound acyltransferase family


    Find genes that share domains with MBOAT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MBOA1_HUMAN, Q6ZNC8
    Function: Acyltransferase which mediates the conversion of lysophosphatidylserine
    (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine
    (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Prefers oleoyl-CoA as the acyl donor.
    Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway
    also known as the Lands cycle
    Catalytic activity: Acyl-CoA + 1-acyl-sn-glycero-3-phosphatidylserine = CoA +
    1,2-diacyl-sn-glycero-3-phosphatidylserine
    Enzyme regulation: Partially inhibited by thimerosal

         Enzyme Numbers (IUBMB): EC 2.3.1.n61 EC 2.3.1.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups IEA--
         
    Find genes that share ontologies with MBOAT1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for MBOAT1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
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    hsa-miR-30c hsa-miR-4311 hsa-miR-181c hsa-miR-30d hsa-miR-103a hsa-miR-3692 hsa-miR-30a hsa-miR-4325
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MBOA1_HUMAN, Q6ZNC8: Membrane; Multi-pass membrane protein (Potential)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with MBOAT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MBOAT1 About    
    See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Glycerophospholipid metabolism0.62
    Phospholipid metabolism0.64
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3Acyl chain remodelling of PC
    Acyl chain remodelling of PE0.85
    Acyl chain remodelling of PS0.00
    4Glycerolipid metabolism
    Glycerolipid metabolism


    Find genes that share SuperPaths with MBOAT1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for MBOAT1
        Acyl chain remodelling of PE
    Acyl chain remodelling of PS


    3 Kegg Pathways  (Kegg details for MBOAT1):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: MBOA1_HUMAN, Q6ZNC8
    Pathway: Lipid metabolism; phospholipid metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MBOAT1
    Interactions:

        Search GeneGlobe Interaction Network for MBOAT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MBOAT1 (ENSP000003249444) via UniProtKB, MINT, STRING, and/or I2D (see all 54)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDS2ENSP000004198794STRING: ENSP00000419879
    EPT1ENSP000002605854STRING: ENSP00000260585
    GPAMENSP000002652764STRING: ENSP00000265276
    GPAT2ENSP000003525474STRING: ENSP00000352547
    PLA2G2AENSP000003642524STRING: ENSP00000364252
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0036150phosphatidylserine acyl-chain remodeling TAS--
    GO:0036152phosphatidylethanolamine acyl-chain remodeling TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0046474glycerophospholipid biosynthetic process TAS--

    Find genes that share ontologies with MBOAT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for MBOAT1 (MBOA1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MBOAT1 gene: 
    NM_001080480.2  

    Unigene Cluster for MBOAT1:

    Membrane bound O-acyltransferase domain containing 1
    Hs.377830  [show with all ESTs]
    Unigene Representative Sequence: NM_001080480
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324607 ENST00000541730(uc003ncx.1 uc011dji.1) ENST00000536798

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    hsa-miR-30c hsa-miR-4311 hsa-miR-181c hsa-miR-30d hsa-miR-103a hsa-miR-3692 hsa-miR-30a hsa-miR-4325
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    Additional mRNA sequence: 

    AB305043.1 AK093994.1 AK131269.1 AK296857.1 AK304748.1 BC045695.1 BC150650.1 BC150652.1 
    NR_073465.1 

    3 DOTS entries:

    DT.409407  DT.40258532  DT.91753362 

    Selected AceView cDNA sequences (see all 59):

    AA513216 AW769471 BQ001168 AI734993 CB130025 CA417675 BC045695 AI377269 
    CA430312 AI024993 AA133721 BF356925 AA078851 AA807913 AW268402 CB131933 
    BI600326 BI089687 AX748402 BE088710 AK131269 BP872150 BX404693 CB850854 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MBOAT1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17
    SP1:                                                                                                                              
    SP2:                                                                                            -                                 
    SP3:              -     -     -     -                                                                                             
    SP4:              -     -                                                                                                         
    SP5:                                                                                                                    -         


    ECgene alternative splicing isoforms for MBOAT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MBOAT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MBOAT1 Expression
    About this image


    MBOAT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Mesencephalic Floor Plate
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Lung (Respiratory System)
             Stem Bronchi
     
     Kidney (Urinary System)
             Metanephros
     
     Lower Urinary Tract (Urinary System)
             Ureter
    MBOAT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MBOAT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.377830

    UniProtKB/Swiss-Prot: MBOA1_HUMAN, Q6ZNC8
    Tissue specificity: Expressed in neutrophils

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MBOAT1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mboat11 , 5 membrane bound O-acyltransferase domain containing more1, 5 84.9(n)1
    83.47(a)1
      13 (13.14 cM)5
    2181211  NM_153546.41  NP_705774.11 
     301364985 
    chicken
    (Gallus gallus)
    Aves MBOAT16
    membrane bound O-acyltransferase domain containing...
    72(a)
    1 ↔ 1
    2(59654813-59707760)
    lizard
    (Anolis carolinensis)
    Reptilia MBOAT16
    membrane bound O-acyltransferase domain containing...
    70(a)
    1 ↔ 1
    4(55849625-55891918)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX853279.12   -- 74.92(n)    BX853279.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mboat11 membrane bound O-acyltransferase domain containing more 61.87(n)
    57(a)
      572841  NM_001007396.2  NP_001007397.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta oys6
    oysgedart
    27(a)
    1 → many
    2R(5923268-5936123)
    worm
    (Caenorhabditis elegans)
    Secernentea mboa-36
    mboa-46
    (see all 3)
    Protein MBOA-3 (mboa-3) mRNA, complete cds
    Protein MBOA-4, isoform b (mboa-4) mRNA, complete ...
    (see all 3)
    35(a)
    28(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    X(5519876-5522819) WBGene00016934
    IV(11157149-11159492) WBGene00007446
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ALE16
    Broad-specificity lysophospholipid acyltransferase...
    21(a)
    1 → many
    XV(659815-661674) YOR175C


    ENSEMBL Gene Tree for MBOAT1 (if available)
    TreeFam Gene Tree for MBOAT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MBOAT1 gene
    LPCAT32  MBOAT42  MBOAT22  MBOAT72  
    1 SIMAP similar gene for MBOAT1 using alignment to 1 protein entry:     MBOA1_HUMAN:
    MBOAT2

    Find genes that share paralogs with MBOAT1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MBOAT1 (see all 2635)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs786621941,2
    F--20099460(+) AAGTGA/GCTCAG 2 -- ds50011Minor allele frequency- G:0.01WA 118
    rs24727571,2
    C,F,H--20099506(-) GATTGA/CATGAA 2 -- ds50015Minor allele frequency- C:0.07NS EA WA 538
    rs776252231,2
    C,F--20099532(+) AAACAC/ATTACT 2 -- ds50011Minor allele frequency- A:0.13WA 118
    rs576681171,2
    F--20099595(+) AAAAAG/AATGTG 2 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1391764171,2
    --20099682(+) GGACCA/GTCTGG 2 -- ds50010--------
    rs1499135571,2
    C--20099715(+) ACACAC/TGCCGC 2 -- ds50010--------
    rs1439599421,2
    --20099719(+) ACGCCA/GCACCA 2 -- ds50010--------
    rs1918166621,2
    --20099829(+) TTGCTC/TTTTGC 2 -- ds50010--------
    rs113985991,2
    C--20099891(+) AAAAA-/ACAACT 2 -- ds50010--------
    rs2000603631,2
    C--20099891(+) AAGTAA/CAAAAA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for MBOAT1 (20100935 - 20212670 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MBOAT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675422CNV Deletion23128226
    esv2731666CNV Deletion23290073
    esv272083CNV Insertion20981092
    esv1703699CNV Insertion17803354
    esv1010968CNV Insertion20482838
    nsv350077CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MBOAT1
    DNA2.0 Custom Variant and Variant Library Synthesis for MBOAT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611732    OMIM disorders: --

    1 disease for MBOAT1:    
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    brachydactyly-syndactyly syndrome


    Find genes that share disorders with MBOAT1           About GenesLikeMe

    Genetic Association Database (GAD): MBOAT1

    Export disorders for MBOAT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MBOAT1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with MBOAT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. (PubMed id 18287005)1, 3 Hishikawa D....Shimizu T. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    2. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PubMed id 18821565)1, 4 Lasky-Su J....Faraone S.V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    3. Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils. (PubMed id 18772128)1, 2 Gijon M.A.... Voelker D.R. (J. Biol. Chem. 2008)
    4. LPT1 encodes a membrane-bound O-acyltransferase involved in the acylation of lysophospholipids in the yeast Saccharomyces cerevisiae. (PubMed id 17890783)1, 2 Tamaki H.... Kumagai H. (J. Biol. Chem. 2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    8. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536)1 Barber M.J....Krauss R.M. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 154141 HGNC: 21579 AceView: OACT1 Ensembl:ENSG00000172197 euGenes: HUgn154141
    ECgene: MBOAT1 Kegg: 154141 H-InvDB: MBOAT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MBOAT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MBOAT1 gene:
    Search GeneIP for patents involving MBOAT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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