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Aliases for MBLAC2 Gene

Aliases for MBLAC2 Gene

  • Metallo-Beta-Lactamase Domain Containing 2 2 3 5
  • EC 3.-.-.- 4

External Ids for MBLAC2 Gene

Previous GeneCards Identifiers for MBLAC2 Gene

  • GC05M089790
  • GC05M084964

Summaries for MBLAC2 Gene

GeneCards Summary for MBLAC2 Gene

MBLAC2 (Metallo-Beta-Lactamase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBLAC2 Gene

Genomics for MBLAC2 Gene

Regulatory Elements for MBLAC2 Gene

Enhancers for MBLAC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MBLAC2 on UCSC Golden Path with GeneCards custom track

Promoters for MBLAC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MBLAC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MBLAC2 Gene

90,458,203 bp from pter
90,474,768 bp from pter
16,566 bases
Minus strand

Genomic View for MBLAC2 Gene

Genes around MBLAC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MBLAC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MBLAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MBLAC2 Gene

Proteins for MBLAC2 Gene

  • Protein details for MBLAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metallo-beta-lactamase domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • D6RJI1
    • Q8IY16
    • Q8N8D8

    Protein attributes for MBLAC2 Gene

    279 amino acids
    Molecular mass:
    31372 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MBLAC2 Gene


neXtProt entry for MBLAC2 Gene

Proteomics data for MBLAC2 Gene at MOPED

Post-translational modifications for MBLAC2 Gene

  • Ubiquitination at Lys 10, Lys 226, and Lys 256
  • Modification sites at PhosphoSitePlus

Other Protein References for MBLAC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MBLAC2 Gene

Domains & Families for MBLAC2 Gene

Protein Domains for MBLAC2 Gene


Suggested Antigen Peptide Sequences for MBLAC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
  • Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
genes like me logo Genes that share domains with MBLAC2: view

No data available for Gene Families for MBLAC2 Gene

Function for MBLAC2 Gene

Enzyme Numbers (IUBMB) for MBLAC2 Gene

Gene Ontology (GO) - Molecular Function for MBLAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MBLAC2: view

Phenotypes for MBLAC2 Gene

genes like me logo Genes that share phenotypes with MBLAC2: view

Animal Model Products

miRNA for MBLAC2 Gene

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MBLAC2 Gene

Localization for MBLAC2 Gene

Subcellular locations from

Jensen Localization Image for MBLAC2 Gene COMPARTMENTS Subcellular localization image for MBLAC2 gene
Compartment Confidence
extracellular 5
nucleus 3
cytoskeleton 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MBLAC2 Gene

Pathways & Interactions for MBLAC2 Gene

SuperPathways for MBLAC2 Gene

No Data Available

Interacting Proteins for MBLAC2 Gene

Gene Ontology (GO) - Biological Process for MBLAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with MBLAC2: view

No data available for Pathways by source and SIGNOR curated interactions for MBLAC2 Gene

Drugs & Compounds for MBLAC2 Gene

No Compound Related Data Available

Transcripts for MBLAC2 Gene

mRNA/cDNA for MBLAC2 Gene

Unigene Clusters for MBLAC2 Gene

Metallo-beta-lactamase domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MBLAC2 Gene

No ASD Table

Relevant External Links for MBLAC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MBLAC2 Gene

mRNA expression in normal human tissues for MBLAC2 Gene

Protein differential expression in normal tissues from HIPED for MBLAC2 Gene

This gene is overexpressed in Brain (23.5), Peripheral blood mononuclear cells (10.2), and Fetal Brain (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MBLAC2 Gene

SOURCE GeneReport for Unigene cluster for MBLAC2 Gene Hs.64004

genes like me logo Genes that share expression patterns with MBLAC2: view

Protein tissue co-expression partners for MBLAC2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MBLAC2 Gene

Orthologs for MBLAC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MBLAC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MBLAC2 35
  • 93.43 (n)
  • 97.49 (a)
  • 97 (a)
(Canis familiaris)
Mammalia MBLAC2 35
  • 94.03 (n)
  • 96.77 (a)
  • 96 (a)
(Mus musculus)
Mammalia Mblac2 35
  • 91.76 (n)
  • 97.13 (a)
Mblac2 16
Mblac2 36
  • 97 (a)
(Pan troglodytes)
Mammalia MBLAC2 35
  • 99.52 (n)
  • 99.64 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Mblac2 35
  • 92 (n)
  • 97.49 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 87 (a)
-- 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia MBLAC2 36
  • 77 (a)
(Gallus gallus)
Aves MBLAC2 35
  • 77.21 (n)
  • 78.18 (a)
  • 77 (a)
(Anolis carolinensis)
Reptilia MBLAC2 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mblac2 35
  • 75.88 (n)
  • 80.73 (a)
(Danio rerio)
Actinopterygii mblac2 35
  • 66.54 (n)
  • 73.99 (a)
mblac2 36
  • 72 (a)
Species with no ortholog for MBLAC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MBLAC2 Gene

Gene Tree for MBLAC2 (if available)
Gene Tree for MBLAC2 (if available)

Paralogs for MBLAC2 Gene Pseudogenes for MBLAC2 Gene

genes like me logo Genes that share paralogs with MBLAC2: view

No data available for Paralogs for MBLAC2 Gene

Variants for MBLAC2 Gene

Sequence variations from dbSNP and Humsavar for MBLAC2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_039956 -
rs2963697 -- 90,471,439(-) AGCAG(A/C)CATTA intron-variant
rs2033261 -- 90,458,285(-) AATGT(A/G)ACATG utr-variant-3-prime
rs33963892 -- 90,459,943(+) TTTAG(-/AT)ATGTC utr-variant-3-prime
rs34017289 -- 90,460,623(+) ATTAT(A/C)CAAAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MBLAC2 Gene

Variant ID Type Subtype PubMed ID
nsv518131 CNV Loss 19592680
nsv882364 CNV Gain 21882294

Variation tolerance for MBLAC2 Gene

Residual Variation Intolerance Score: 45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.72% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MBLAC2 Gene

Disorders for MBLAC2 Gene

Relevant External Links for MBLAC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MBLAC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MBLAC2 Gene

Publications for MBLAC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. (PMID: 20458337) Buschow S.I. … Stoorvogel W. (Immunol. Cell Biol. 2010) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MBLAC2 Gene

Sources for MBLAC2 Gene