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Aliases for MBLAC2 Gene

Aliases for MBLAC2 Gene

  • Metallo-Beta-Lactamase Domain Containing 2 2 3
  • EC 3.-.-.- 4

External Ids for MBLAC2 Gene

Previous GeneCards Identifiers for MBLAC2 Gene

  • GC05M089790
  • GC05M084964

Summaries for MBLAC2 Gene

GeneCards Summary for MBLAC2 Gene

MBLAC2 (Metallo-Beta-Lactamase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBLAC2 Gene

Genomics for MBLAC2 Gene

Regulatory Elements for MBLAC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MBLAC2 Gene

Start:
90,458,203 bp from pter
End:
90,474,768 bp from pter
Size:
16,566 bases
Orientation:
Minus strand

Genomic View for MBLAC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MBLAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MBLAC2 Gene

Proteins for MBLAC2 Gene

  • Protein details for MBLAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68D91-MBLC2_HUMAN
    Recommended name:
    Metallo-beta-lactamase domain-containing protein 2
    Protein Accession:
    Q68D91
    Secondary Accessions:
    • D6RJI1
    • Q8IY16
    • Q8N8D8

    Protein attributes for MBLAC2 Gene

    Size:
    279 amino acids
    Molecular mass:
    31372 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MBLAC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MBLAC2 Gene

Proteomics data for MBLAC2 Gene at MOPED

Post-translational modifications for MBLAC2 Gene

  • Ubiquitination at Lys10, Lys226, and Lys256
  • Modification sites at PhosphoSitePlus

Other Protein References for MBLAC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MBLAC2 Gene

Domains for MBLAC2 Gene

Protein Domains for MBLAC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MBLAC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68D91

UniProtKB/Swiss-Prot:

MBLC2_HUMAN :
  • Q68D91
Family:
  • Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
genes like me logo Genes that share domains with MBLAC2: view

No data available for Gene Families for MBLAC2 Gene

Function for MBLAC2 Gene

Enzyme Numbers (IUBMB) for MBLAC2 Gene

Gene Ontology (GO) - Molecular Function for MBLAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MBLAC2: view

Animal Model Products

CRISPR Products

miRNA for MBLAC2 Gene

miRTarBase miRNAs that target MBLAC2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MBLAC2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MBLAC2 Gene

Localization for MBLAC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MBLAC2 Gene COMPARTMENTS Subcellular localization image for MBLAC2 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MBLAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with MBLAC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MBLAC2 Gene

Pathways for MBLAC2 Gene

SuperPathways for MBLAC2 Gene

No Data Available

Interacting Proteins for MBLAC2 Gene

Gene Ontology (GO) - Biological Process for MBLAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with MBLAC2: view

No data available for Pathways by source for MBLAC2 Gene

Transcripts for MBLAC2 Gene

mRNA/cDNA for MBLAC2 Gene

Unigene Clusters for MBLAC2 Gene

Metallo-beta-lactamase domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MBLAC2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MBLAC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MBLAC2 Gene

No ASD Table

Relevant External Links for MBLAC2 Gene

GeneLoc Exon Structure for
MBLAC2
ECgene alternative splicing isoforms for
MBLAC2

Expression for MBLAC2 Gene

mRNA expression in normal human tissues for MBLAC2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MBLAC2 Gene

SOURCE GeneReport for Unigene cluster for MBLAC2 Gene Hs.64004

genes like me logo Genes that share expressions with MBLAC2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MBLAC2 Gene

Orthologs for MBLAC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MBLAC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MBLAC2 35
  • 99.52 (n)
  • 99.64 (a)
MBLAC2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MBLAC2 35
  • 93.43 (n)
  • 97.49 (a)
MBLAC2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MBLAC2 35
  • 94.03 (n)
  • 96.77 (a)
MBLAC2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mblac2 35
  • 91.76 (n)
  • 97.13 (a)
Mblac2 16
Mblac2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MBLAC2 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mblac2 35
  • 92 (n)
  • 97.49 (a)
chicken
(Gallus gallus)
Aves MBLAC2 35
  • 77.21 (n)
  • 78.18 (a)
MBLAC2 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MBLAC2 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mblac2 35
  • 75.88 (n)
  • 80.73 (a)
zebrafish
(Danio rerio)
Actinopterygii mblac2 35
  • 66.54 (n)
  • 73.99 (a)
mblac2 36
  • 72 (a)
OneToOne
Species with no ortholog for MBLAC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MBLAC2 Gene

ENSEMBL:
Gene Tree for MBLAC2 (if available)
TreeFam:
Gene Tree for MBLAC2 (if available)

Paralogs for MBLAC2 Gene

Pseudogenes.org Pseudogenes for MBLAC2 Gene

genes like me logo Genes that share paralogs with MBLAC2: view

No data available for Paralogs for MBLAC2 Gene

Variants for MBLAC2 Gene

Sequence variations from dbSNP and Humsavar for MBLAC2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs2033261 -- 90,458,285(-) AATGT(A/G)ACATG utr-variant-3-prime
rs2963697 -- 90,471,439(-) AGCAG(A/C)CATTA intron-variant
rs7700312 -- 90,462,515(+) aaact(A/G)taaga intron-variant
rs7711257 -- 90,464,381(+) gcctc(A/G)gcaaa intron-variant
rs7730433 -- 90,464,074(+) gcaaa(G/T)aaatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MBLAC2 Gene

Variant ID Type Subtype PubMed ID
nsv518131 CNV Loss 19592680
nsv882364 CNV Gain 21882294

Relevant External Links for MBLAC2 Gene

HapMap Linkage Disequilibrium report
MBLAC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MBLAC2 Gene

Disorders for MBLAC2 Gene

No disorders were found for MBLAC2 Gene.

No data available for UniProtKB/Swiss-Prot for MBLAC2 Gene

Publications for MBLAC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. (PMID: 20458337) Buschow S.I. … Stoorvogel W. (Immunol. Cell Biol. 2010) 3
  3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for MBLAC2 Gene

Sources for MBLAC2 Gene

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