MBLAC1 Gene
protein-coding GIFtS: 34
GCID: GC07P099724
|
|
metallo-beta-lactamase domain containing 1
| |
Aliases
for MBLAC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Metallo-Beta-Lactamase Domain Containing 11 2 | | MGC494161 | | Metallo-Beta-Lactamase Domain-Containing Protein 12 | | EC 3.-.-.-3 |
Export aliases for MBLAC1 gene to outside databasesPrevious GC identifers: GC07P099563 GC07P094359 |
Summaries
for MBLAC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for MBLAC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MBLAC1 gene promoter:
Max1 Tal-1beta Arnt E47 CREB POU2F1 POU2F1a c-Myc ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for MBLAC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MBLAC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22MBLAC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P099724: view genomic region
(about GC identifiers)
Start:
|
99,724,317 bp from pter |
End:
|
99,726,121 bp from pter |
Size:
|
1,805 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 99,084,436-99,086,240 |
|
Proteins
for MBLAC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MBLC1_HUMAN, A4D2B0 (See
protein sequence)Recommended Name: Metallo-beta-lactamase domain-containing protein 1 Size: 266 amino acids; 27202 Da
Cofactor: Binds 2 zinc ions per subunit (By similarity)
Secondary accessions: Q8N5X8Explore the universe of human proteins at neXtProt for MBLAC1: NX_A4D2B0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A4D2B0
MBLAC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_981942.1
ENSEMBL proteins: ENSP00000381150 ENSP00000406055
Human Recombinant Protein Products:
MBLAC1 Antibody Products:
Assay Products for MBLAC1: |
Protein
Domains /
Families
for MBLAC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MBLAC1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A4D2B0ProtoNet protein and cluster: A4D2B0 UniProtKB/Swiss-Prot: MBLC1_HUMAN, A4D2B0Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family |
Function
for MBLAC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Number (IUBMB): EC 3.-.-.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MBLAC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MBLAC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MBLAC1 (NM_203397) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MBLAC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MBLAC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MBLAC1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016787 | hydrolase activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
MBLAC1 for ontologies About GeneDecksing
|
Pathways & Interactions
for MBLAC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MBLAC1
|
Drugs & Compounds
for MBLAC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MBLAC1
Search CenterWatch for drugs/clinical trials and news about MBLAC1 / MBLC1
|
Transcripts
for MBLAC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MBLAC1 gene: NM_203397.1 Unigene Cluster for MBLAC1: Metallo-beta-lactamase domain containing 1 Hs.632319 [show with all ESTs]Unigene Representative Sequence: NM_2033972 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000398075(uc003utp.3) ENST00000421390
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MBLAC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MBLAC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MBLAC1 (NM_203397) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MBLAC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MBLAC1 |
Additional cDNA sequence: BC031288.1 2 DOTS entries: DT.86858903 DT.100663512 11 AceView cDNA sequences: AW772344 BM547133 BQ441096 BI603487 BC031288 BF754820 CB269491 AW449216 BI666652 BG953759 BQ333210
GeneLoc Exon Structure
|
Expression
for MBLAC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MBLAC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGGACCGAGC
About this image
See MBLAC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MBLAC1
SOURCE GeneReport for Unigene cluster: Hs.632319
SABiosciences Custom PCR Arrays for MBLAC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MBLAC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MBLAC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MBLAC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MBLAC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MBLAC1 |
Orthologs
for MBLAC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MBLAC1 gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for MBLAC1 (if available)
TreeFam Gene Tree for MBLAC1 (if available) |
Paralogs
for MBLAC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MBLAC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MBLAC1 (99724317 - 99726121 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MBLAC1
1 CNV: 2104 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MBLAC1 |
|
Disorders
/ Diseases
for MBLAC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for MBLAC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MBLAC1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MBLAC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for MBLAC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MBLAC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MBLAC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MBLAC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MBLAC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MBLAC1 gene:
Search GeneIP for patents involving MBLAC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MBLAC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MBLAC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MBLAC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MBLAC1 | | | OriGene Protein Over-expression Lysate for MBLAC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MBLAC1 | | OriGene 3'-UTR Clone for MBLAC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MBLAC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MBLAC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MBLAC1 | | OriGene Custom Protein Services for MBLAC1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MBLAC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MBLAC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MBLAC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MBLAC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MBLAC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MBLAC1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MBLAC1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MBLAC1 |
|  |  |  | | | | Search ThermoFisher Antibodies for MBLAC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MBLAC1 |
|
|
|
|
