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Aliases for MBIP Gene

Aliases for MBIP Gene

  • MAP3K12 Binding Inhibitory Protein 1 2 3 5
  • MAPK Upstream Kinase-Binding Inhibitory Protein 4
  • MUK-Binding Inhibitory Protein 4

External Ids for MBIP Gene

Previous GeneCards Identifiers for MBIP Gene

  • GC14M034147
  • GC14M030625
  • GC14M034757
  • GC14M035837
  • GC14M036767
  • GC14M016882

Summaries for MBIP Gene

GeneCards Summary for MBIP Gene

MBIP (MAP3K12 Binding Inhibitory Protein 1) is a Protein Coding gene. Among its related pathways are Chromatin organization. GO annotations related to this gene include identical protein binding and protein kinase inhibitor activity.

UniProtKB/Swiss-Prot for MBIP Gene

  • Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBIP Gene

Genomics for MBIP Gene

Regulatory Elements for MBIP Gene

Enhancers for MBIP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G036272 1.8 Ensembl 17.4 +48.3 48276 0.4 PKNOX1 ZSCAN4 FEZF1 ZNF384 ZIC2 ZNF2 ZNF324 CTBP1 ZBTB48 PATZ1 MBIP RPL29P3 NKX2-8 RN7SKP21
GH14G036345 1.8 VISTA 17.3 -25.2 -25238 1.6 ZNF146 FOXA2 SMARCA4 ZNF580 EP300 MBIP RPL29P3 NKX2-8 ENSG00000283098 DPPA3P2
GH14G036269 1.5 ENCODE 10.8 +51.1 51130 0.9 OSR2 L3MBTL2 ZSCAN4 POU5F1 ZIC2 MBIP RPL29P3 NKX2-8 RN7SKP21
GH14G036318 1.1 ENCODE 11.5 +0.7 739 2.7 PKNOX1 FOXA2 MLX CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 YY1 MBIP RN7SKP21
GH14G036281 0.7 ENCODE 6.8 +39.2 39167 0.2 ATF1 L3MBTL2 HCFC1 NFYC SIX5 ELF4 MNT ETS1 NFYB GABPB1 SFTA3 NKX2-1-AS1 NKX2-1 RPL29P3 NKX2-8 MBIP RN7SKP21
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MBIP on UCSC Golden Path with GeneCards custom track

Promoters for MBIP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000067696 576 2200 PKNOX1 FOXA2 MLX CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 YY1

Genomic Location for MBIP Gene

Chromosome:
14
Start:
36,298,558 bp from pter
End:
36,320,676 bp from pter
Size:
22,119 bases
Orientation:
Minus strand

Genomic View for MBIP Gene

Genes around MBIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MBIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MBIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MBIP Gene

Proteins for MBIP Gene

  • Protein details for MBIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS73-MBIP1_HUMAN
    Recommended name:
    MAP3K12-binding inhibitory protein 1
    Protein Accession:
    Q9NS73
    Secondary Accessions:
    • Q86TZ2
    • Q96AS5
    • Q9BS93
    • Q9NZE1

    Protein attributes for MBIP Gene

    Size:
    344 amino acids
    Molecular mass:
    39281 Da
    Quaternary structure:
    • Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, KAT14 and WDR5.
    SequenceCaution:
    • Sequence=CAD62615.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MBIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MBIP Gene

Post-translational modifications for MBIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MBIP Gene

Domains & Families for MBIP Gene

Gene Families for MBIP Gene

Protein Domains for MBIP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MBIP: view

No data available for UniProtKB/Swiss-Prot for MBIP Gene

Function for MBIP Gene

Molecular function for MBIP Gene

UniProtKB/Swiss-Prot Function:
Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Gene Ontology (GO) - Molecular Function for MBIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity TAS 10801814
GO:0005515 protein binding IPI 16189514
GO:0030366 molybdopterin synthase activity IBA --
GO:0042802 identical protein binding IPI 16189514
genes like me logo Genes that share ontologies with MBIP: view

Phenotypes for MBIP Gene

genes like me logo Genes that share phenotypes with MBIP: view

Animal Model Products

CRISPR Products

miRNA for MBIP Gene

miRTarBase miRNAs that target MBIP

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MBIP Gene

Localization for MBIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MBIP Gene

Nucleus. Cytoplasm. Note=Shows a cytoplasmic localization when coexpressed with MAP3K12.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MBIP gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for MBIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with MBIP: view

Pathways & Interactions for MBIP Gene

genes like me logo Genes that share pathways with MBIP: view

Pathways by source for MBIP Gene

Gene Ontology (GO) - Biological Process for MBIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000173 inactivation of MAPK activity involved in osmosensory signaling pathway TAS 10801814
GO:0032324 molybdopterin cofactor biosynthetic process IBA --
GO:0043966 histone H3 acetylation IDA 18838386
genes like me logo Genes that share ontologies with MBIP: view

No data available for SIGNOR curated interactions for MBIP Gene

Drugs & Compounds for MBIP Gene

No Compound Related Data Available

Transcripts for MBIP Gene

Unigene Clusters for MBIP Gene

MAP3K12 binding inhibitory protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MBIP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - - - -
SP3: - -
SP4:
SP5: - -
SP6:

Relevant External Links for MBIP Gene

GeneLoc Exon Structure for
MBIP
ECgene alternative splicing isoforms for
MBIP

Expression for MBIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MBIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MBIP Gene

This gene is overexpressed in Seminal vesicle (47.2) and Blymphocyte (17.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MBIP Gene



Protein tissue co-expression partners for MBIP Gene

NURSA nuclear receptor signaling pathways regulating expression of MBIP Gene:

MBIP

SOURCE GeneReport for Unigene cluster for MBIP Gene:

Hs.368647

mRNA Expression by UniProt/SwissProt for MBIP Gene:

Q9NS73-MBIP1_HUMAN
Tissue specificity: Ubiquitous. High expression seen in the heart and lung.

Evidence on tissue expression from TISSUES for MBIP Gene

  • Kidney(4.3)
  • Bone marrow(4.2)
  • Nervous system(2.4)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with MBIP: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MBIP Gene

Orthologs for MBIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MBIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MBIP 34 35
  • 99.61 (n)
cow
(Bos Taurus)
Mammalia MBIP 34 35
  • 92.34 (n)
dog
(Canis familiaris)
Mammalia MBIP 34 35
  • 92.25 (n)
rat
(Rattus norvegicus)
Mammalia Mbip 34
  • 87.59 (n)
mouse
(Mus musculus)
Mammalia Mbip 34 16 35
  • 86.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MBIP 35
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MBIP 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves MBIP 34 35
  • 72.47 (n)
lizard
(Anolis carolinensis)
Reptilia MBIP 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mbip 34
  • 63.78 (n)
Str.1990 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6450 34
zebrafish
(Danio rerio)
Actinopterygii mbip 34 35
  • 57 (n)
Dr.28396 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10182 35
  • 30 (a)
OneToOne
Species where no ortholog for MBIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MBIP Gene

ENSEMBL:
Gene Tree for MBIP (if available)
TreeFam:
Gene Tree for MBIP (if available)

Paralogs for MBIP Gene

No data available for Paralogs for MBIP Gene

Variants for MBIP Gene

Sequence variations from dbSNP and Humsavar for MBIP Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000066679 -- 36,310,592(+) AATAT(A/G)ACAGA intron-variant
rs1000234271 -- 36,304,957(+) CCAAC(A/G)AAAGT intron-variant
rs1000357909 -- 36,306,694(+) ATAAG(A/T)ATTAT intron-variant
rs1000538148 -- 36,312,360(+) ATTCT(A/C)CTTCA intron-variant
rs1000610255 -- 36,320,193(+) AGCCT(C/G)CCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MBIP Gene

Variant ID Type Subtype PubMed ID
dgv83e55 CNV gain 17911159
nsv1040487 CNV gain 25217958
nsv1054427 CNV gain 25217958
nsv518747 CNV loss 19592680
nsv832771 CNV loss 17160897

Variation tolerance for MBIP Gene

Residual Variation Intolerance Score: 26.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MBIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MBIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MBIP Gene

Disorders for MBIP Gene

Relevant External Links for MBIP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MBIP

No disorders were found for MBIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MBIP Gene

Publications for MBIP Gene

  1. MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/Dual leucine zipper-bearing kinase/leucine zipper protein kinase. (PMID: 10801814) Fukuyama K. … Ohno S. (J. Biol. Chem. 2000) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64
  4. A High-Density Map for Navigating the Human Polycomb Complexome. (PMID: 27705803) Hauri S. … Beisel C. (Cell Rep 2016) 3 64
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64

Products for MBIP Gene

Sources for MBIP Gene

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