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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MBIP Gene

protein-coding   GIFtS: 48
GCID: GC14M036767

MAP3K12 binding inhibitory protein 1
  Search for MBIP
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MBIP    

Aliases
for MBIP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
MAP3K12 Binding Inhibitory Protein 11 2
MAPK Upstream Kinase-Binding Inhibitory Protein2 3
MUK-Binding Inhibitory Protein2 3
MAP3K12-Binding Inhibitory Protein 12

External Ids:    HGNC: 204271   Entrez Gene: 515622   Ensembl: ENSG000001513327   OMIM: 6094315   UniProtKB: Q9NS733   

Export aliases for MBIP gene to outside databases

Previous GC identifers: GC14M034147 GC14M030625 GC14M034757 GC14M035837 GC14M016882


Summaries
for MBIP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MBIP1_HUMAN, Q9NS73
Function: Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC
complex, a complex with histone acetyltransferase activity on histones H3 and H4




Genomic Views
for MBIP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MBIP gene promoter:
         FOXI1   HFH-3   MEF-2A   Nkx6-1   HOXA5   CUTL1   aMEF-2   Pax-4a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MBIP promoter sequence
   Search SABiosciences Chromatin IP Primers for MBIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MBIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13.3   Ensembl cytogenetic band:  14q13.3   HGNC cytogenetic band: 14q13.2

MBIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MBIP gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M036767:  view genomic region     (about GC identifiers)

Start:
 36,767,764 bp from pter      End:
 36,789,882 bp from pter
Size:
 22,119 bases      Orientation:
 minus strand

Proteins
for MBIP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MBIP1_HUMAN, Q9NS73 (See protein sequence)
Recommended Name: MAP3K12-binding inhibitory protein 1  
Size: 344 amino acids; 39281 Da
Subunit: Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5,
YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, CSRP2BP and WDR5
Subcellular location: Nucleus. Cytoplasm. Note=Shows a cytoplasmic localization when coexpressed with MAP3K12
Sequence caution: Sequence=CAD62615.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q86TZ2 Q96AS5 Q9BS93 Q9NZE1
Alternative splicing: 4 isoforms:  Q9NS73-1   Q9NS73-2   Q9NS73-3   Q9NS73-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MBIP: NX_Q9NS73

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NS73

    • MBIP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138363.1  NP_057670.2  

    ENSEMBL proteins: 
     ENSP00000399718   ENSP00000324444   ENSP00000352517   ENSP00000451005   ENSP00000379620  
     ENSP00000451079   ENSP00000452075   ENSP00000452070  

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    Uscn Proteins for MBIP

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005671Ada2/Gcn5/Ada3 transcription activator complex IDA18838386
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--


    MBIP for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for MBIP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MBIP for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026062 MBIP

    Graphical View of Domain Structure for InterPro Entry Q9NS73

    ProtoNet protein and cluster: Q9NS73


    Function
    for MBIP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MBIP1_HUMAN, Q9NS73
    Function: Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC
    complex, a complex with histone acetyltransferase activity on histones H3 and H4

    miRNA
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    hsa-miR-142-5p hsa-miR-3154
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004860protein kinase inhibitor activity TAS10801814
    GO:0005515protein binding IPI19060904
    GO:0042802identical protein binding IPI19060904


    MBIP for ontologies           About GeneDecksing



    Pathways & Interactions
    for MBIP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MBIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/55 Interacting proteins for MBIP (Q9NS731, 2, 3 ENSP000003244444) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSRP2BPQ9H8E81, 2, 3, ENSP000002788164EBI-741953,EBI-750907 MINT-67943 I2D: score=5 STRING: ENSP00000278816
    FXR2P511161, 2, 3, ENSP000002501134EBI-741953,EBI-740459 MINT-67977 I2D: score=5 STRING: ENSP00000250113
    CCDC85BQ158342, 3, ENSP000003116954MINT-67364 I2D: score=5 STRING: ENSP00000311695
    NDEL1Q9GZM82, 3, ENSP000003339824MINT-66794 I2D: score=5 STRING: ENSP00000333982
    NINLQ9Y2I62, 3, ENSP000002788864MINT-68225 I2D: score=5 STRING: ENSP00000278886
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000173inactivation of MAPK activity involved in osmosensory signaling pathway TAS10801814
    GO:0043966histone H3 acetylation IDA18838386


    MBIP for ontologies           About GeneDecksing



    Drugs & Compounds
    for MBIP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MBIP
    Search CenterWatch for drugs/clinical trials and news about MBIP / MBIP1 

    Transcripts
    for MBIP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MBIP gene (2 alternative transcripts): 
    NM_001144891.1  NM_016586.2  

    Unigene Cluster for MBIP:

    MAP3K12 binding inhibitory protein 1
    Hs.368647  [show with all ESTs]
    Unigene Representative Sequence: AF208857
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000416007(uc001wtm.2 uc001wto.2 uc010tpy.1 uc001wtn.2)
    ENST00000318473 ENST00000359527 ENST00000553877 ENST00000557044 ENST00000553977
    ENST00000396329 ENST00000554855 ENST00000553298 ENST00000553549 ENST00000556427


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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MBIP:
    hsa-miR-142-5p hsa-miR-3154
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB038523.1 AF208857.1 AK293473.1 AK315290.1 BC005197.1 BC016821.1 BX248287.1 

    8 DOTS entries:

    DT.40207398  DT.91667543  DT.97778888  DT.91748825  DT.100639753  DT.40198477  DT.100671322  DT.97768486 

    24/168 AceView cDNA sequences (see all 168):

    H56604 AA761801 AA828263 CR610521 CR590283 AA972708 BM661864 AA761503 
    AI640292 BX248287 CR594524 BU687161 BM510713 AI074368 BM802512 AA745614 
    AI859712 CB962207 BG547103 BF513672 AL699838 AW419109 BC005197 AW865274 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MBIP (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                    -                             -                       -         
    SP2:                    -                             -                 -     -         
    SP3:                                                                    -     -         
    SP4:                                                                                    
    SP5:                    -     -                                                         


    ECgene alternative splicing isoforms for MBIP

    Expression
    for MBIP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MBIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAATAAACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MBIP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Nkx2-1 GFP+ cells (Efficient derivation...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MBIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MBIP

    SOURCE GeneReport for Unigene cluster: Hs.368647

    UniProtKB/Swiss-Prot: MBIP1_HUMAN, Q9NS73
    Tissue specificity: Ubiquitous. High expression seen in the heart and lung

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    In Situ
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    Orthologs
    for MBIP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MBIP gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mbip1 , 5 MAP3K12 binding inhibitory protein 11, 5 86.73(n)1
    82.01(a)1    		   12 (24.30 cM)5
    2175881  NM_145442.21  NP_663417.11 
     563283065 
    chicken
    (Gallus gallus)    		 Aves MBIP1 MAP3K12 binding inhibitory protein 1 72.47(n)
    71.98(a)    		   423329  XM_421246.3  XP_421246.2 
    lizard
    (Anolis carolinensis)    		 Reptilia MBIP6
    		 --
    		 70(a)
    		 1 ↔ 1
    		 1(24464893-24476131)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.64502 Xenopus laevis transcribed sequence with weak similarity more 79.41(n)    BU915682.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.283962 Danio rerio cDNA clone IMAGE6791366, partial cds 74.52(n)    BC057252.1 


    ENSEMBL Gene Tree for MBIP (if available)
    TreeFam Gene Tree for MBIP (if available) 

    Paralogs
    for MBIP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for MBIP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/312 NCBI SNPs in MBIP are shown (see all 312)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1906616421,2
    		--36767359(+) TGCTGA/CGATTA 2 -- int10--------
    rs71427901,2
    		C,F,H,--36767424(+) TTCCAC/TATAAC 2 -- int110Minor allele frequency- T:0.05NS EA NA WA 1210
    rs1828782301,2
    		--36767455(+) GTTTAA/GTTTAT 2 -- int10--------
    rs284993811,2
    		C,--36767660(+) TTCTTC/TGTAAC 2 -- int14Minor allele frequency- T:0.05NA WA 124
    rs1487893671,2
    		C,--36767725(+) AGAAC-/AAAGACA 2 -- int10--------
    rs118489821,2
    		C,F,H,--36767734(+) ACAGAT/ATAAGT 2 -- int17Minor allele frequency- A:0.32NA WA CSA 130
    rs791841161,2
    		F,--36767899(+) GCAAAG/CTACTG 2 -- ut311Minor allele frequency- C:0.08WA 118
    rs1856883391,2
    		--36767934(+) ATCAAC/TGTTAC 2 -- ut310--------
    rs1175231701,2
    		F,--36767945(+) AAATAT/CAAAGT 2 -- ut311Minor allele frequency- C:0.02NA 120
    rs1498820781,2
    		--36768108(+) CATTCA/GTTATT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for MBIP (36767764 - 36789882 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MBIP
         1 CNV: 8766

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    Disorders / Diseases
    for MBIP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MBIP for disorders           About MalaCards

    MBIP for disorders           About GeneDecksing

    OMIM gene information: 609431    OMIM disorders: --


    Export disorders for MBIP gene to outside databases

    Publications
    for MBIP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MBIP gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with MBIP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/Dual leucine zipper-bearing kinase/leucine zipper protein kinase. (PubMed id 10801814)1, 2, 3, 9 Fukuyama K.... Ohno S. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    4. Discovery of common variants associated with low TSH l evels and thyroid cancer risk. (PubMed id 22267200)1 Gudmundsson J....Stefansson K. (2012)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    9. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
    10. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. (PubMed id 19103755)2 Guelman S.... Zha J. (2009)

    External Searches for MBIP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing MBIP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51562 HGNC: 20427 AceView: MBIP Ensembl:ENSG00000151332 euGenes: HUgn51562
    ECgene: MBIP H-InvDB: MBIP

    Other Databases showing MBIP gene

    (According to HUGE)
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    Specialized Databases showing MBIP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MBIP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MBIP gene:
    Search GeneIP for patents involving MBIP

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