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MBD6 Gene

protein-coding   GIFtS: 51
GCID: GC12P057916

Methyl-CpG Binding Domain Protein 6

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Methyl-CpG Binding Domain Protein 61 2
Methyl-CpG-Binding Protein MBD62 3
Methyl-CpG-Binding Domain Protein 62
KIAA18873

External Ids:    HGNC: 204451   Entrez Gene: 1147852   Ensembl: ENSG000001669877   UniProtKB: Q96DN63   
ORGUL members:         

Export aliases for MBD6 gene to outside databases

Previous GC identifers: GC12P058059 GC12P057633 GC12P056202 GC12P054932


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MBD6 Gene:
MBD6 (methyl-CpG binding domain protein 6) is a protein-coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is MBD5.

UniProtKB/Swiss-Prot: MBD6_HUMAN, Q96DN6
Function: Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MBD6 gene promoter:
         Max1   PPAR-gamma1   PPAR-gamma2   c-Myc   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MBD6 promoter sequence
   Search Chromatin IP Primers for MBD6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MBD6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.2

MBD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MBD6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P057916:  view genomic region     (about GC identifiers)

Start:
57,914,493 bp from pter      End:
57,923,931 bp from pter
Size:
9,439 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MBD6_HUMAN, Q96DN6 (See protein sequence)
Recommended Name: Methyl-CpG-binding domain protein 6  
Size: 1003 amino acids; 101201 Da
Secondary accessions: Q8N3M0 Q8NA81 Q96Q00

Explore the universe of human proteins at neXtProt for MBD6: NX_Q96DN6

Explore proteomics data for MBD6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MBD6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_443129.3  
    ENSEMBL proteins: 
     ENSP00000448070   ENSP00000450370   ENSP00000449603   ENSP00000347896   ENSP00000448202  
     ENSP00000446481   ENSP00000447365   ENSP00000449541   ENSP00000446834   ENSP00000449749  
     ENSP00000450160   ENSP00000447418   ENSP00000390211  

    MBD6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MBD6

     
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    Cloud-Clone Corp. ELISAs for MBD6
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    Search eBioscience for ELISAs for MBD6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001739 Methyl_CpG_DNA-bd
     IPR016177 DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q96DN6

    ProtoNet protein and cluster: Q96DN6

    UniProtKB/Swiss-Prot: MBD6_HUMAN, Q96DN6
    Domain: The MBD domain is necessary for chromocentric localization
    Similarity: Contains 1 MBD (methyl-CpG-binding) domain


    Find genes that share domains with MBD6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MBD6_HUMAN, Q96DN6
    Function: Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677NOT DNA binding IDA--
    GO:0003682chromatin binding IDA--
         
    Find genes that share ontologies with MBD6           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Mbd6 (no phenotypes)

    Find genes that share phenotypes with MBD6           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MBD6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MBD6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MBD6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MBD6

    miRNA
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    miRTarBase miRNAs that target MBD6:
    hsa-let-7b-5p (MIRT052082), hsa-mir-24-3p (MIRT030471), hsa-mir-124-3p (MIRT022555)

    Block miRNA regulation of human, mouse, rat MBD6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MBD6 (see all 95):
    hsa-miR-579 hsa-miR-607 hsa-miR-1321 hsa-miR-631 hsa-miR-30d hsa-miR-3653 hsa-miR-3921 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidMBD6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MBD6
    Predesigned siRNA for gene silencing in human, mouse, rat MBD6

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for MBD6
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    GenScript: all cDNA clones in your preferred vector: MBD6 (NM_052897)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MBD6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MBD6

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MBD6 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MBD6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MBD6_HUMAN, Q96DN6: Nucleus. Chromosome. Note=Associated with pericentric heterochromatin in about 25% of the
    cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005694chromosome ----
    GO:0010369chromocenter IDA--

    Find genes that share ontologies with MBD6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MBD6
    Interactions:

        Search GeneGlobe Interaction Network for MBD6

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for MBD6 (Q96DN62, 3 ENSP000003478964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DUSP12Q9UNI62, 3, ENSP000003569204MINT-65783 I2D: score=5 STRING: ENSP00000356920
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    DUSP1ENSP000002392234STRING: ENSP00000239223
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MBD6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MBD6 gene: 
    NM_052897.3  

    Unigene Cluster for MBD6:

    Methyl-CpG binding domain protein 6
    Hs.524523  [show with all ESTs]
    Unigene Representative Sequence: NM_052897
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000548887 ENST00000551351 ENST00000549231 ENST00000546805 ENST00000355673(uc001soj.1 uc001sok.1 uc001sol.1)
    ENST00000546632 ENST00000549623 ENST00000552255 ENST00000549042 ENST00000552659
    ENST00000547545 ENST00000548550 ENST00000552163 ENST00000547844 ENST00000431731

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MBD6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MBD6 (see all 95):
    hsa-miR-579 hsa-miR-607 hsa-miR-1321 hsa-miR-631 hsa-miR-30d hsa-miR-3653 hsa-miR-3921 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidMBD6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MBD6
    Predesigned siRNA for gene silencing in human, mouse, rat MBD6
    Clone
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    OriGene clones in human, mouse for MBD6 (see all 7)
    OriGene ORF clones in mouse, rat for MBD6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MBD6 (NM_052897)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MBD6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MBD6
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MBD6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MBD6
      QuantiTect SYBR Green Assays in human, mouse, rat MBD6
      QuantiFast Probe-based Assays in human, mouse, rat MBD6

    Additional mRNA sequence: 

    AB067474.1 AK056399.1 AK093078.1 AK296990.1 AL834230.1 BC034295.1 BC040149.1 BC051370.1 
    BC065530.1 CR627478.1 

    19 DOTS entries:

    DT.121174597  DT.100788549  DT.416114  DT.100884095  DT.97847009  DT.100028132  DT.100673382  DT.121174537 
    DT.121174578  DT.101972327  DT.121174370  DT.121174522  DT.121174551  DT.121174584  DT.92403881  DT.100884101 
    DT.101975158  DT.121174553  DT.91909957 

    Selected AceView cDNA sequences (see all 247):

    AA749267 AI979278 AW304422 AW173060 AA961062 AK056399 BM912745 BM714347 
    BP354005 BM980662 BC051370 CB123586 BQ024087 CD364937 AI337023 BU688256 
    AI239833 BU902130 CD365165 AW518868 AI767627 CD723964 BI335776 BU553233 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MBD6 (see all 18)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                      -                       -                                                                                             
    SP4:                                      -     -                 -                                                                                             
    SP5:                                                              -                                                                                             

    ExUns: 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for MBD6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MBD6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCAGCTGTC
    MBD6 Expression
    About this image


    MBD6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Thyroid (Endocrine System)
    MBD6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MBD6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524523
        Custom PCR Arrays for MBD6
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat MBD6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MBD6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MBD6 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mbd61 , 5 methyl-CpG binding domain protein 61, 5 90.64(n)1
    91.88(a)1
      10 (74.50 cM)5
    1109621  NM_033072.21  NP_149063.21 
     1272819565 
    lizard
    (Anolis carolinensis)
    Reptilia MBD66
    methyl-CpG binding domain protein 6
    35(a)
    1 ↔ 1
    GL343212.1(515986-557664)
    zebrafish
    (Danio rerio)
    Actinopterygii mbd66
    methyl-CpG binding domain protein 6
    17(a)
    1 ↔ 1
    6(58770954-58813043) ENSDARG00000086980
    fruit fly
    (Drosophila melanogaster)
    Insecta sba6
    six-banded
    8(a)
    1 → many
    3R(19719889-19748695)


    ENSEMBL Gene Tree for MBD6 (if available)
    TreeFam Gene Tree for MBD6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MBD6 gene
    MBD52  
    2 SIMAP similar genes for MBD6 using alignment to 11 protein entries:     MBD6_HUMAN (see all proteins):
    DKFZp762N1313    MBD5

    Find genes that share paralogs with MBD6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MBD6 (see all 809)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452609221,2
    C,F--54930377(+) AACCCC/ACCAGG 1 -- int11Minor allele frequency- A:0.00NA 4550
    rs1467575471,2
    C--54930576(+) GGCTGG/TCTGGG 1 -- int10--------
    rs1920617761,2
    --54930585(+) GGCACC/TCCTAA 1 -- int10--------
    rs1820816151,2
    --54930699(+) GCAGAA/GACCAG 1 -- int10--------
    rs1403276991,2
    --54930727(+) ATATCC/TATCTT 1 -- int10--------
    rs7760381,2
    C,F,A,H--54930875(+) cagtgG/Tctcat 1 -- int120Minor allele frequency- T:0.23NS EA NA WA CSA 1992
    rs16692911,2
    C,H--54930920(+) ggcggA/Ctcacc 1 -- int17Minor allele frequency- C:0.00NA WA CSA 15
    rs17098741,2
    C,F,A--54930925(+) CTCACC/TGGAGG 1 -- int14Minor allele frequency- T:0.50NA WA 8
    rs1851542201,2
    --54930930(+) CGGAGA/GTCAGG 1 -- int10--------
    rs359247741,2
    C--54931144(+) GTCTC-/AAAAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for MBD6 (57914493 - 57923931 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MBD6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv724CNV Insertion18451855
    nsv469411CNV Loss19166990
    nsv899119CNV Loss21882294
    nsv899120CNV Loss21882294
    nsv899117CNV Loss21882294
    nsv428283CNV Gain18775914
    nsv899118CNV Gain21882294
    dgv513e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): MBD6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MBD6
    DNA2.0 Custom Variant and Variant Library Synthesis for MBD6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    1 disease from the University of Copenhagen DISEASES database for MBD6:
    Rett syndrome

    Find genes that share disorders with MBD6           About GenesLikeMe

    Genetic Association Database (GAD): MBD6
    Human Genome Epidemiology (HuGE) Navigator: MBD6 (1 document)

    Export disorders for MBD6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MBD6 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with MBD6)
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    1. The human proteins MBD5 and MBD6 associate with heterochromatin but they do not bind methylated DNA. (PubMed id 20700456)1, 2 Laget S.... Defossez P.A. (PLoS ONE 2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Comparative study of methyl-CpG-binding domain proteins. (PubMed id 12529184)1, 3 Roloff T.C.... Nuber U.A. (BMC Genomics 2003)
    4. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    5. MBD6 is a direct target of Oct4 and controls the stemness and differentiation of adipose tissue-derived stem cells. (PubMed id 23052207)1 Jung J.S....Kang S.K. (Cell. Mol. Life Sci. 2013)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. The expanding role of MBD genes in autism: identification of a MECP2 duplication and novel alterations in MBD5, MBD6, and SETDB1. (PubMed id 23055267)1 Cukier H.N....Gilbert J.R. (Autism Res 2012)
    8. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114785 HGNC: 20445 AceView: MBD6 Ensembl:ENSG00000166987 euGenes: HUgn114785
    ECgene: MBD6 H-InvDB: MBD6

    (According to HUGE)
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    HUGE: KIAA1887

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MBD6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MBD6 gene:
    Search GeneIP for patents involving MBD6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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