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Aliases for MBD6 Gene

Aliases for MBD6 Gene

  • Methyl-CpG Binding Domain Protein 6 2 3
  • Methyl-CpG-Binding Protein MBD6 4
  • KIAA1887 4

External Ids for MBD6 Gene

Summaries for MBD6 Gene

GeneCards Summary for MBD6 Gene

MBD6 (Methyl-CpG Binding Domain Protein 6) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is MBD5.

UniProtKB/Swiss-Prot for MBD6 Gene

  • Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro)

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBD6 Gene

Genomics for MBD6 Gene

Genomic Location for MBD6 Gene

57,520,710 bp from pter
57,530,148 bp from pter
9,439 bases
Plus strand

Genomic View for MBD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MBD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MBD6 Gene

Regulatory Elements for MBD6 Gene

Proteins for MBD6 Gene

  • Protein details for MBD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyl-CpG-binding domain protein 6
    Protein Accession:
    Secondary Accessions:
    • Q8N3M0
    • Q8NA81
    • Q96Q00

    Protein attributes for MBD6 Gene

    1003 amino acids
    Molecular mass:
    101201 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MBD6 Gene

Proteomics data for MBD6 Gene at MOPED

Post-translational modifications for MBD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MBD6 Gene

Domains for MBD6 Gene

Protein Domains for MBD6 Gene



  • The MBD domain is necessary for chromocentric localization:
    • Q96DN6
  • Contains 1 MBD (methyl-CpG-binding) domain.:
    • Q96DN6
genes like me logo Genes that share domains with MBD6: view

No data available for Gene Families for MBD6 Gene

Function for MBD6 Gene

Molecular function for MBD6 Gene

UniProtKB/Swiss-Prot Function: Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro)

Gene Ontology (GO) - Molecular Function for MBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 NOT DNA binding IDA 20700456
GO:0003682 chromatin binding IDA 20700456
genes like me logo Genes that share ontologies with MBD6: view

miRNA for MBD6 Gene

miRTarBase miRNAs that target MBD6

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MBD6 Gene

Localization for MBD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MBD6 Gene

Nucleus. Chromosome. Note=Associated with pericentric heterochromatin in about 25% of the cells.

Subcellular locations from

Jensen Localization Image for MBD6 Gene COMPARTMENTS Subcellular localization image for MBD6 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MBD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0010369 chromocenter IDA 20700456
genes like me logo Genes that share ontologies with MBD6: view

Pathways for MBD6 Gene

SuperPathways for MBD6 Gene

No Data Available

Interacting Proteins for MBD6 Gene

Gene Ontology (GO) - Biological Process for MBD6 Gene


No data available for Pathways by source for MBD6 Gene

Transcripts for MBD6 Gene

Unigene Clusters for MBD6 Gene

Methyl-CpG binding domain protein 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MBD6 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a ·
SP3: - -
SP4: - - -
SP5: -
SP6: -
SP7: - - - - -
SP8: - - - - - -
SP9: - - - - -
SP10: - - - - -
SP11: - - - - -
SP12: - -

ExUns: 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c
SP18: - -

Relevant External Links for MBD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MBD6 Gene

mRNA expression in normal human tissues for MBD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MBD6 Gene

This gene is overexpressed in Whole Blood (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MBD6 Gene

SOURCE GeneReport for Unigene cluster for MBD6 Gene Hs.524523

genes like me logo Genes that share expressions with MBD6: view

Orthologs for MBD6 Gene

This gene was present in the common ancestor of animals.

Orthologs for MBD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MBD6 36
  • 99.8 (n)
  • 99.9 (a)
MBD6 37
  • 100 (a)
(Bos Taurus)
Mammalia MBD6 36
  • 94.32 (n)
  • 95.21 (a)
MBD6 37
  • 94 (a)
(Canis familiaris)
Mammalia MBD6 36
  • 93.25 (n)
  • 94.52 (a)
MBD6 37
  • 94 (a)
(Mus musculus)
Mammalia Mbd6 36
  • 90.64 (n)
  • 91.88 (a)
Mbd6 16
Mbd6 37
  • 93 (a)
(Rattus norvegicus)
Mammalia Mbd6 36
  • 90.87 (n)
  • 91.79 (a)
(Anolis carolinensis)
Reptilia MBD6 37
  • 35 (a)
(Danio rerio)
Actinopterygii mbd6 37
  • 17 (a)
fruit fly
(Drosophila melanogaster)
Insecta sba 37
  • 8 (a)
Species with no ortholog for MBD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MBD6 Gene

Gene Tree for MBD6 (if available)
Gene Tree for MBD6 (if available)

Paralogs for MBD6 Gene

Paralogs for MBD6 Gene

genes like me logo Genes that share paralogs with MBD6: view

Variants for MBD6 Gene

Sequence variations from dbSNP and Humsavar for MBD6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1148554 -- 57,525,324(-) GAAGG(A/G)TCAGC intron-variant
rs1148555 -- 57,524,851(+) AGAGT(A/G)CAGAG intron-variant
rs1148556 -- 57,523,742(+) CCATA(C/T)TCCTG intron-variant
rs1284605 -- 57,527,405(+) CATGG(C/T)CTATC intron-variant
rs1709873 -- 57,528,876(+) AGTTT(C/T)CCACC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MBD6 Gene

Variant ID Type Subtype PubMed ID
nsv899117 CNV Loss 21882294
nsv899118 CNV Gain 21882294
dgv513e1 CNV Complex 17122850
nsv428283 CNV Gain 18775914
nsv469411 CNV Loss 19166990
nsv899119 CNV Loss 21882294
nsv899120 CNV Loss 21882294
nsv724 CNV Insertion 18451855

Relevant External Links for MBD6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for MBD6 Gene

(1) University of Copenhagen DISEASES for MBD6 Gene

Relevant External Links for MBD6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MBD6: view

No data available for UniProtKB/Swiss-Prot for MBD6 Gene

Publications for MBD6 Gene

  1. Comparative study of methyl-CpG-binding domain proteins. (PMID: 12529184) Roloff T.C. … Nuber U.A. (BMC Genomics 2003) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The human proteins MBD5 and MBD6 associate with heterochromatin but they do not bind methylated DNA. (PMID: 20700456) Laget S. … Defossez P.A. (PLoS ONE 2010) 3 4
  4. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MBD6 Gene

Sources for MBD6 Gene

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