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Aliases for MBD3L5 Gene

Aliases for MBD3L5 Gene

  • Methyl-CpG Binding Domain Protein 3 Like 5 2 3 5
  • Methyl-CpG Binding Domain Protein 3-Like 5 2
  • MBD3-Like Protein 5 4

External Ids for MBD3L5 Gene

Previous GeneCards Identifiers for MBD3L5 Gene

  • GC19P006983

Summaries for MBD3L5 Gene

GeneCards Summary for MBD3L5 Gene

MBD3L5 (Methyl-CpG Binding Domain Protein 3 Like 5) is a Protein Coding gene. An important paralog of this gene is MBD3L4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBD3L5 Gene

Genomics for MBD3L5 Gene

Regulatory Elements for MBD3L5 Gene

Enhancers for MBD3L5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F006765 0.2 ENCODE 16.2 -262.6 -262648 4.5 HDGF ATF1 PKNOX1 ARID4B SIN3A ETS1 ZNF121 GTF3C2 GLIS2 ZNF207 SH2D3A FLJ25758 MBD3L5 MBD3L3 LOC390877 XAB2 RPL21P129 ZNF557 ACSBG2 ENSG00000267571
GH19F006717 0.2 ENCODE 16.2 -312.3 -312290 0.2 HDGF ATF1 PKNOX1 ARNT YBX1 ZNF2 ZNF302 GATA2 ZNF207 PAF1 XAB2 ENSG00000267571 FLJ25758 MBD3L5 LOC390877 MBD3L3 ACSBG2 GPR108 ENSG00000269680 ALKBH7
GH19F006733 0.8 Ensembl ENCODE 16.2 -292.2 -292178 8.1 CREB3L1 ZFP64 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 GPR108 ENSG00000269680 FLJ25758 MBD3L5 MBD3L3 LOC390877 ACSBG2 ALKBH7 VAV1 VMAC
GH19F006582 1.3 FANTOM5 Ensembl ENCODE 16.2 -442.6 -442634 9.3 HDGF PKNOX1 ARNT WRNIP1 SIN3A YBX1 ZNF48 ZNF121 GLIS2 ZNF143 LOC390877 FLJ25758 MBD3L5 MBD3L3 ACSBG2 ALKBH7 ENSG00000267571 PRR22 CD70 RPL36
GH19F006457 0.7 ENCODE 16.2 -570.5 -570452 3.4 PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC25A23 VMAC ENSG00000267571 LOC390877 MBD3L3 MBD3L5 FLJ25758 ZNF557 ACSBG2 MIR6791
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MBD3L5 on UCSC Golden Path with GeneCards custom track

Genomic Location for MBD3L5 Gene

7,029,930 bp from pter
7,033,011 bp from pter
3,082 bases
Plus strand

Genomic View for MBD3L5 Gene

Genes around MBD3L5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MBD3L5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MBD3L5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MBD3L5 Gene

Proteins for MBD3L5 Gene

  • Protein details for MBD3L5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative methyl-CpG-binding domain protein 3-like 5
    Protein Accession:

    Protein attributes for MBD3L5 Gene

    208 amino acids
    Molecular mass:
    22976 Da
    Quaternary structure:
    No Data Available
    • The MBD3L proteins are encoded by strongly repeated regions of the 19p13 chromosome. The exact number of functional copies is unclear, and some of them may represent pseudogenes.

neXtProt entry for MBD3L5 Gene

Post-translational modifications for MBD3L5 Gene

No Post-translational modifications

Other Protein References for MBD3L5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MBD3L5 Gene

Domains & Families for MBD3L5 Gene

Protein Domains for MBD3L5 Gene

Suggested Antigen Peptide Sequences for MBD3L5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MBD3L family.
  • Belongs to the MBD3L family.
genes like me logo Genes that share domains with MBD3L5: view

No data available for Gene Families for MBD3L5 Gene

Function for MBD3L5 Gene

Gene Ontology (GO) - Molecular Function for MBD3L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008327 methyl-CpG binding IBA --
genes like me logo Genes that share ontologies with MBD3L5: view

Phenotypes for MBD3L5 Gene

MGI mutant phenotypes for MBD3L5:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with MBD3L5: view

Animal Models for MBD3L5 Gene

MGI Knock Outs for MBD3L5:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MBD3L5 Gene

Localization for MBD3L5 Gene

Subcellular locations from

Jensen Localization Image for MBD3L5 Gene COMPARTMENTS Subcellular localization image for MBD3L5 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MBD3L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with MBD3L5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MBD3L5 Gene

Pathways & Interactions for MBD3L5 Gene

SuperPathways for MBD3L5 Gene

No Data Available

Interacting Proteins for MBD3L5 Gene

Gene Ontology (GO) - Biological Process for MBD3L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006346 methylation-dependent chromatin silencing IBA --
genes like me logo Genes that share ontologies with MBD3L5: view

No data available for Pathways by source and SIGNOR curated interactions for MBD3L5 Gene

Transcripts for MBD3L5 Gene

mRNA/cDNA for MBD3L5 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MBD3L5 Gene

No ASD Table

Relevant External Links for MBD3L5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MBD3L5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MBD3L5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MBD3L5 Gene

This gene is overexpressed in Esophagus (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MBD3L5 Gene

Protein tissue co-expression partners for MBD3L5 Gene

NURSA nuclear receptor signaling pathways regulating expression of MBD3L5 Gene:


SOURCE GeneReport for Unigene cluster for MBD3L5 Gene:

genes like me logo Genes that share expression patterns with MBD3L5: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MBD3L5 Gene

Orthologs for MBD3L5 Gene

This gene was present in the common ancestor of animals.

Orthologs for MBD3L5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MBD3L2 34
  • 98.22 (n)
-- 35
  • 96 (a)
-- 35
  • 95 (a)
-- 35
  • 95 (a)
(Canis familiaris)
Mammalia LOC100688619 34
  • 63.27 (n)
-- 35
  • 35 (a)
(Bos Taurus)
Mammalia MBD3L3 34
  • 63.15 (n)
-- 35
  • 49 (a)
(Rattus norvegicus)
Mammalia Mbd3l2 34
  • 57.56 (n)
(Mus musculus)
Mammalia Mbd3l2 34 16 35
  • 56.91 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 24 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 21 (a)
(Gallus gallus)
Aves MBD3 35
  • 25 (a)
(Danio rerio)
Actinopterygii mbd3b 35
  • 24 (a)
mbd3a 35
  • 22 (a)
fruit fly
(Drosophila melanogaster)
Insecta MBD-like 35
  • 12 (a)
Species where no ortholog for MBD3L5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MBD3L5 Gene

Gene Tree for MBD3L5 (if available)
Gene Tree for MBD3L5 (if available)

Paralogs for MBD3L5 Gene

Paralogs for MBD3L5 Gene

(6) SIMAP similar genes for MBD3L5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MBD3L5: view

Variants for MBD3L5 Gene

Sequence variations from dbSNP and Humsavar for MBD3L5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs111314830 -- 7,032,155(+) CCCTG(A/C)AGGGG intron-variant
rs1651761 -- 7,032,143(+) GACTT(C/T)AGCAA intron-variant
rs1651763 -- 7,033,336(+) CACCA(G/T)GCTGG downstream-variant-500B
rs1690412 -- 7,030,769(-) ATAAC(G/T)TTCCA intron-variant
rs1690419 -- 7,032,898(+) GAAGC(G/T)CAGTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MBD3L5 Gene

Variant ID Type Subtype PubMed ID
dgv136e55 CNV gain 17911159
dgv1983e59 CNV duplication 20981092
dgv3421n100 CNV gain 25217958
dgv393n27 CNV gain 19166990
dgv6237n54 CNV gain 21841781
dgv6241n54 CNV gain 21841781
dgv6242n54 CNV gain 21841781
esv24114 CNV gain+loss 19812545
esv2751809 CNV gain 17911159
esv2751810 CNV loss 17911159
esv2760525 CNV gain 21179565
esv2762977 CNV gain+loss 21179565
esv33729 CNV gain+loss 17666407
esv3431845 CNV duplication 20981092
esv3574297 CNV gain 25503493
nsv1056752 CNV gain 25217958
nsv1057286 CNV loss 25217958
nsv1061916 CNV gain 25217958
nsv1071901 CNV deletion 25765185
nsv1141327 CNV duplication 24896259
nsv1153776 CNV duplication 26484159
nsv510880 OTHER complex 20534489
nsv517794 CNV gain+loss 19592680
nsv578476 CNV loss 21841781
nsv578487 CNV gain+loss 21841781
nsv821572 CNV duplication 20802225
nsv953956 CNV duplication 24416366
nsv960777 CNV duplication 23825009
nsv960778 CNV duplication 23825009

Variation tolerance for MBD3L5 Gene

Gene Damage Index Score: 1.19; 23.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MBD3L5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MBD3L5 Gene

Disorders for MBD3L5 Gene

Relevant External Links for MBD3L5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MBD3L5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MBD3L5 Gene

Publications for MBD3L5 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64

Products for MBD3L5 Gene

Sources for MBD3L5 Gene

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