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Aliases for MBD3L5 Gene

Aliases for MBD3L5 Gene

  • Methyl-CpG Binding Domain Protein 3 Like 5 2 3 5
  • Methyl-CpG Binding Domain Protein 3-Like 5 2
  • MBD3-Like Protein 5 4

External Ids for MBD3L5 Gene

Previous GeneCards Identifiers for MBD3L5 Gene

  • GC19P006983

Summaries for MBD3L5 Gene

GeneCards Summary for MBD3L5 Gene

MBD3L5 (Methyl-CpG Binding Domain Protein 3 Like 5) is a Protein Coding gene. An important paralog of this gene is MBD3L3.

Additional gene information for MBD3L5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBD3L5 Gene

Genomics for MBD3L5 Gene

Regulatory Elements for MBD3L5 Gene

Enhancers for MBD3L5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H006270 2 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -754.6 -754578 10 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 DUS3L ZNF557 KHSRP SNRPEP4 SAFB ENSG00000267571 VMAC ACSBG2 ALKBH7 GPR108
GH19H006587 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -442.2 -442163 1 HDGF PKNOX1 ARNT YBX1 ZBTB40 ZNF366 SIRT6 ZNF143 ZNF207 ATF7 DENND1C LOC390877 FLJ25758 MBD3L5 MBD3L3 ACSBG2 ZNF557 ARHGEF18 DUS3L VMAC
GH19H006717 1.6 Ensembl ENCODE dbSUPER 14.6 -308.8 -308772 6 HDGF PKNOX1 FOXA2 MLX ARID4B YBX1 DMAP1 ZNF2 YY1 SLC30A9 GPR108 ZNF557 FLJ25758 MBD3L5 MBD3L3 LOC390877 DUS3L ACSBG2 XAB2 TNFSF14
GH19H006515 1.6 Ensembl ENCODE dbSUPER 14.6 -513.3 -513296 2 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZNF143 ZNF207 DEK SP3 ZC3H11A KHSRP SNRPEP4 DUS3L ENSG00000267571 ZNF557 VMAC LOC390877 FLJ25758 MBD3L5 MBD3L3
GH19H007690 1.5 FANTOM5 ENCODE dbSUPER 14.6 +662.0 662000 2 HDGF PKNOX1 BMI1 YBX1 BATF ZSCAN5C ZNF143 ZNF207 ATF7 RUNX3 FCER2 RPL21P129 LYPLA2P2 FLJ25758 MBD3L3 ENSG00000261866 MBD3L5 LINC01862 STXBP2 ARHGEF18
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MBD3L5 on UCSC Golden Path with GeneCards custom track

Genomic Location for MBD3L5 Gene

Chromosome:
19
Start:
7,029,930 bp from pter
End:
7,033,011 bp from pter
Size:
3,082 bases
Orientation:
Plus strand

Genomic View for MBD3L5 Gene

Genes around MBD3L5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MBD3L5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MBD3L5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MBD3L5 Gene

Proteins for MBD3L5 Gene

  • Protein details for MBD3L5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NJ08-MB3L5_HUMAN
    Recommended name:
    Putative methyl-CpG-binding domain protein 3-like 5
    Protein Accession:
    A6NJ08

    Protein attributes for MBD3L5 Gene

    Size:
    208 amino acids
    Molecular mass:
    22976 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The MBD3L proteins are encoded by strongly repeated regions of the 19p13 chromosome. The exact number of functional copies is unclear, and some of them may represent pseudogenes.

neXtProt entry for MBD3L5 Gene

Post-translational modifications for MBD3L5 Gene

No Post-translational modifications

Other Protein References for MBD3L5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MBD3L5 Gene

Domains & Families for MBD3L5 Gene

Gene Families for MBD3L5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MBD3L5 Gene

Suggested Antigen Peptide Sequences for MBD3L5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NJ08

UniProtKB/Swiss-Prot:

MB3L5_HUMAN :
  • Belongs to the MBD3L family.
Family:
  • Belongs to the MBD3L family.
genes like me logo Genes that share domains with MBD3L5: view

Function for MBD3L5 Gene

Phenotypes From GWAS Catalog for MBD3L5 Gene

Gene Ontology (GO) - Molecular Function for MBD3L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008327 methyl-CpG binding IBA --
genes like me logo Genes that share ontologies with MBD3L5: view

Phenotypes for MBD3L5 Gene

MGI mutant phenotypes for MBD3L5:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with MBD3L5: view

Animal Models for MBD3L5 Gene

MGI Knock Outs for MBD3L5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MBD3L5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MBD3L5 Gene

Localization for MBD3L5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MBD3L5 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MBD3L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with MBD3L5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MBD3L5 Gene

Pathways & Interactions for MBD3L5 Gene

SuperPathways for MBD3L5 Gene

No Data Available

Interacting Proteins for MBD3L5 Gene

Gene Ontology (GO) - Biological Process for MBD3L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006346 methylation-dependent chromatin silencing IBA --
genes like me logo Genes that share ontologies with MBD3L5: view

No data available for Pathways by source and SIGNOR curated interactions for MBD3L5 Gene

Drugs & Compounds for MBD3L5 Gene

No Compound Related Data Available

Transcripts for MBD3L5 Gene

mRNA/cDNA for MBD3L5 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MBD3L5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MBD3L5 Gene

No ASD Table

Relevant External Links for MBD3L5 Gene

GeneLoc Exon Structure for
MBD3L5
ECgene alternative splicing isoforms for
MBD3L5

Expression for MBD3L5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MBD3L5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MBD3L5 Gene

This gene is overexpressed in Esophagus (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MBD3L5 Gene



Protein tissue co-expression partners for MBD3L5 Gene

NURSA nuclear receptor signaling pathways regulating expression of MBD3L5 Gene:

MBD3L5

SOURCE GeneReport for Unigene cluster for MBD3L5 Gene:

Hs.717312
genes like me logo Genes that share expression patterns with MBD3L5: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MBD3L5 Gene

Orthologs for MBD3L5 Gene

This gene was present in the common ancestor of animals.

Orthologs for MBD3L5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MBD3L2 33
  • 98.22 (n)
-- 34
  • 96 (a)
ManyToMany
-- 34
  • 95 (a)
ManyToMany
-- 34
  • 95 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC100688619 33
  • 63.27 (n)
-- 34
  • 35 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MBD3L3 33
  • 63.15 (n)
-- 34
  • 49 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mbd3l2 33
  • 57.56 (n)
mouse
(Mus musculus)
Mammalia Mbd3l2 33 16 34
  • 56.91 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 24 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 21 (a)
OneToMany
chicken
(Gallus gallus)
Aves MBD3 34
  • 25 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii mbd3b 34
  • 24 (a)
ManyToMany
mbd3a 34
  • 22 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta MBD-like 34
  • 12 (a)
OneToMany
Species where no ortholog for MBD3L5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MBD3L5 Gene

ENSEMBL:
Gene Tree for MBD3L5 (if available)
TreeFam:
Gene Tree for MBD3L5 (if available)

Paralogs for MBD3L5 Gene

Paralogs for MBD3L5 Gene

(6) SIMAP similar genes for MBD3L5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MBD3L5: view

Variants for MBD3L5 Gene

Sequence variations from dbSNP and Humsavar for MBD3L5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1007329409 -- 7,032,296(+) TTCTT(-/TTC)TTTTC intron-variant
rs1016487589 -- 7,032,989(+) CTTTA(A/C)TAAAA utr-variant-3-prime
rs1025648351 -- 7,033,125(+) TTAAT(-/TG)TTTTT downstream-variant-500B
rs1035933855 -- 7,033,310(+) TTGTA(G/T)TTTTA downstream-variant-500B
rs1037547858 -- 7,033,478(+) GCCTG(C/G)CGCTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MBD3L5 Gene

Variant ID Type Subtype PubMed ID
dgv136e55 CNV gain 17911159
dgv1983e59 CNV duplication 20981092
dgv3421n100 CNV gain 25217958
dgv393n27 CNV gain 19166990
dgv6237n54 CNV gain 21841781
dgv6241n54 CNV gain 21841781
dgv6242n54 CNV gain 21841781
esv24114 CNV gain+loss 19812545
esv2751809 CNV gain 17911159
esv2751810 CNV loss 17911159
esv2760525 CNV gain 21179565
esv2762977 CNV gain+loss 21179565
esv33729 CNV gain+loss 17666407
esv3431845 CNV duplication 20981092
esv3574297 CNV gain 25503493
nsv1056752 CNV gain 25217958
nsv1057286 CNV loss 25217958
nsv1061916 CNV gain 25217958
nsv1071901 CNV deletion 25765185
nsv1141327 CNV duplication 24896259
nsv1153776 CNV duplication 26484159
nsv510880 OTHER complex 20534489
nsv517794 CNV gain+loss 19592680
nsv578476 CNV loss 21841781
nsv578487 CNV gain+loss 21841781
nsv821572 CNV duplication 20802225
nsv953956 CNV duplication 24416366
nsv960777 CNV duplication 23825009
nsv960778 CNV duplication 23825009

Variation tolerance for MBD3L5 Gene

Gene Damage Index Score: 1.19; 23.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MBD3L5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MBD3L5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MBD3L5 Gene

Disorders for MBD3L5 Gene

Relevant External Links for MBD3L5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MBD3L5

No disorders were found for MBD3L5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MBD3L5 Gene

Publications for MBD3L5 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60

Products for MBD3L5 Gene

Sources for MBD3L5 Gene

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