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Aliases for MBD3L4 Gene

Aliases for MBD3L4 Gene

  • Methyl-CpG Binding Domain Protein 3 Like 4 2 3 5
  • MBD3-Like Protein 4 4

External Ids for MBD3L4 Gene

Previous GeneCards Identifiers for MBD3L4 Gene

  • GC19M006990

Summaries for MBD3L4 Gene

Entrez Gene Summary for MBD3L4 Gene

  • This gene encodes a member of a family of proteins that are related to methyl-CpG-binding proteins but lack the methyl-CpG binding domain. There is no definitive support for transcription of this locus, and the transcript structure is inferred from other family members. [provided by RefSeq, Aug 2009]

GeneCards Summary for MBD3L4 Gene

MBD3L4 (Methyl-CpG Binding Domain Protein 3 Like 4) is a Protein Coding gene. An important paralog of this gene is MBD3L3.

Additional gene information for MBD3L4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBD3L4 Gene

Genomics for MBD3L4 Gene

GeneHancer (GH) Regulatory Elements for MBD3L4 Gene

Promoters and enhancers for MBD3L4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I007040 Promoter 0.5 EPDnew 550.8 +0.6 594 0.1 MBD3L4 MBD3L5
GH19I007049 Promoter 0.5 EPDnew 0.4 -8.5 -8461 0.1 MBD3L2 MBD3L4
GH19I007030 Promoter 0.5 EPDnew 0.4 +10.3 10304 0.1 MBD3L5 MBD3L4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MBD3L4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MBD3L4 gene promoter:

Genomic Locations for MBD3L4 Gene

Genomic Locations for MBD3L4 Gene
3,083 bases
Minus strand

Genomic View for MBD3L4 Gene

Genes around MBD3L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MBD3L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MBD3L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MBD3L4 Gene

Proteins for MBD3L4 Gene

  • Protein details for MBD3L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative methyl-CpG-binding domain protein 3-like 4
    Protein Accession:

    Protein attributes for MBD3L4 Gene

    208 amino acids
    Molecular mass:
    23121 Da
    Quaternary structure:
    No Data Available
    • The MBD3L proteins are encoded by strongly repeated regions of the 19p13 chromosome. The exact number of functional copies is unclear, and some of them may represent pseudogenes.

neXtProt entry for MBD3L4 Gene

Post-translational modifications for MBD3L4 Gene

No Post-translational modifications

Other Protein References for MBD3L4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MBD3L4 Gene

Domains & Families for MBD3L4 Gene

Gene Families for MBD3L4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MBD3L4 Gene

Suggested Antigen Peptide Sequences for MBD3L4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MBD3L family.
  • Belongs to the MBD3L family.
genes like me logo Genes that share domains with MBD3L4: view

Function for MBD3L4 Gene

Gene Ontology (GO) - Molecular Function for MBD3L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008327 methyl-CpG binding IBA --
genes like me logo Genes that share ontologies with MBD3L4: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MBD3L4 Gene

Localization for MBD3L4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MBD3L4 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MBD3L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with MBD3L4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MBD3L4 Gene

Pathways & Interactions for MBD3L4 Gene

SuperPathways for MBD3L4 Gene

No Data Available

Interacting Proteins for MBD3L4 Gene

Gene Ontology (GO) - Biological Process for MBD3L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA --
GO:0006346 methylation-dependent chromatin silencing IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MBD3L4: view

No data available for Pathways by source and SIGNOR curated interactions for MBD3L4 Gene

Drugs & Compounds for MBD3L4 Gene

No Compound Related Data Available

Transcripts for MBD3L4 Gene

mRNA/cDNA for MBD3L4 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MBD3L4 Gene

No ASD Table

Relevant External Links for MBD3L4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MBD3L4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MBD3L4 Gene

NURSA nuclear receptor signaling pathways regulating expression of MBD3L4 Gene:


SOURCE GeneReport for Unigene cluster for MBD3L4 Gene:

genes like me logo Genes that share expression patterns with MBD3L4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MBD3L4 Gene

Orthologs for MBD3L4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MBD3L4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MBD3L2 33
  • 98.24 (n)
-- 34
  • 97 (a)
-- 34
  • 96 (a)
-- 34
  • 96 (a)
(Canis familiaris)
Mammalia LOC100688619 33
  • 63.27 (n)
-- 34
  • 35 (a)
(Bos Taurus)
Mammalia MBD3L3 33
  • 63.15 (n)
-- 34
  • 49 (a)
(Rattus norvegicus)
Mammalia Mbd3l2 33
  • 57.4 (n)
(Mus musculus)
Mammalia Mbd3l2 33 34
  • 56.91 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 23 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 21 (a)
(Gallus gallus)
Aves MBD3 34
  • 25 (a)
(Danio rerio)
Actinopterygii mbd3b 34
  • 24 (a)
mbd3a 34
  • 22 (a)
fruit fly
(Drosophila melanogaster)
Insecta MBD-like 34
  • 12 (a)
Species where no ortholog for MBD3L4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MBD3L4 Gene

Gene Tree for MBD3L4 (if available)
Gene Tree for MBD3L4 (if available)

Paralogs for MBD3L4 Gene

Paralogs for MBD3L4 Gene

(5) SIMAP similar genes for MBD3L4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MBD3L4: view

Variants for MBD3L4 Gene

Sequence variations from dbSNP and Humsavar for MBD3L4 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1006243984 -- 7,039,961(-) A/C intron_variant
rs1006502342 -- 7,037,358(-) C/T downstream_transcript_variant
rs1008031456 -- 7,037,307(-) C/G downstream_transcript_variant
rs1013806536 -- 7,040,253(-) G/C upstream_transcript_variant
rs1014905723 -- 7,040,014(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MBD3L4 Gene

Variant ID Type Subtype PubMed ID
dgv136e55 CNV gain 17911159
dgv1701n106 OTHER inversion 24896259
dgv1984e59 CNV duplication 20981092
dgv3421n100 CNV gain 25217958
dgv393n27 CNV gain 19166990
dgv6237n54 CNV gain 21841781
dgv6241n54 CNV gain 21841781
dgv6242n54 CNV gain 21841781
dgv6243n54 CNV loss 21841781
dgv6244n54 CNV loss 21841781
esv24114 CNV gain+loss 19812545
esv2751809 CNV gain 17911159
esv2751810 CNV loss 17911159
esv2760525 CNV gain 21179565
esv2762977 CNV gain+loss 21179565
esv3323576 CNV duplication 20981092
esv33729 CNV gain+loss 17666407
esv3574297 CNV gain 25503493
nsv1056752 CNV gain 25217958
nsv1057286 CNV loss 25217958
nsv1061916 CNV gain 25217958
nsv1141328 CNV duplication 24896259
nsv1152474 CNV duplication 26484159
nsv510880 OTHER complex 20534489
nsv517794 CNV gain+loss 19592680
nsv578487 CNV gain+loss 21841781
nsv578490 CNV loss 21841781
nsv821572 CNV duplication 20802225
nsv953956 CNV duplication 24416366
nsv960778 CNV duplication 23825009

Additional Variant Information for MBD3L4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MBD3L4 Gene

Disorders for MBD3L4 Gene

Additional Disease Information for MBD3L4

No disorders were found for MBD3L4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MBD3L4 Gene

Publications for MBD3L4 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58

Products for MBD3L4 Gene

Sources for MBD3L4 Gene

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