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Aliases for MBD3L4 Gene

Aliases for MBD3L4 Gene

  • Methyl-CpG Binding Domain Protein 3 Like 4 2 3
  • Methyl-CpG Binding Domain Protein 3-Like 4 5
  • MBD3-Like Protein 4 4

External Ids for MBD3L4 Gene

Previous GeneCards Identifiers for MBD3L4 Gene

  • GC19M006990

Summaries for MBD3L4 Gene

Entrez Gene Summary for MBD3L4 Gene

  • This gene encodes a member of a family of proteins that are related to methyl-CpG-binding proteins but lack the methyl-CpG binding domain. There is no definitive support for transcription of this locus, and the transcript structure is inferred from other family members. [provided by RefSeq, Aug 2009]

GeneCards Summary for MBD3L4 Gene

MBD3L4 (Methyl-CpG Binding Domain Protein 3 Like 4) is a Protein Coding gene. An important paralog of this gene is MBD3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBD3L4 Gene

Genomics for MBD3L4 Gene

Regulatory Elements for MBD3L4 Gene

Enhancers for MBD3L4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MBD3L4 on UCSC Golden Path with GeneCards custom track

Genomic Location for MBD3L4 Gene

7,037,744 bp from pter
7,040,826 bp from pter
3,083 bases
Minus strand

Genomic View for MBD3L4 Gene

Genes around MBD3L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MBD3L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MBD3L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MBD3L4 Gene

Proteins for MBD3L4 Gene

  • Protein details for MBD3L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative methyl-CpG-binding domain protein 3-like 4
    Protein Accession:

    Protein attributes for MBD3L4 Gene

    208 amino acids
    Molecular mass:
    23121 Da
    Quaternary structure:
    No Data Available
    • The MBD3L proteins are encoded by strongly repeated regions of the 19p13 chromosome. The exact number of functional copies is unclear, and some of them may represent pseudogenes.

neXtProt entry for MBD3L4 Gene

Proteomics data for MBD3L4 Gene at MOPED

Post-translational modifications for MBD3L4 Gene

No Post-translational modifications

Other Protein References for MBD3L4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MBD3L4 Gene

Domains & Families for MBD3L4 Gene

Protein Domains for MBD3L4 Gene

Suggested Antigen Peptide Sequences for MBD3L4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MBD3L family.
  • Belongs to the MBD3L family.
genes like me logo Genes that share domains with MBD3L4: view

No data available for Gene Families for MBD3L4 Gene

Function for MBD3L4 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MBD3L4 Gene

Localization for MBD3L4 Gene

Subcellular locations from

Jensen Localization Image for MBD3L4 Gene COMPARTMENTS Subcellular localization image for MBD3L4 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MBD3L4 Gene

Pathways & Interactions for MBD3L4 Gene

SuperPathways for MBD3L4 Gene

No Data Available

Interacting Proteins for MBD3L4 Gene

Gene Ontology (GO) - Biological Process for MBD3L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006346 methylation-dependent chromatin silencing IBA --
genes like me logo Genes that share ontologies with MBD3L4: view

No data available for Pathways by source and SIGNOR curated interactions for MBD3L4 Gene

Drugs & Compounds for MBD3L4 Gene

No Compound Related Data Available

Transcripts for MBD3L4 Gene

mRNA/cDNA for MBD3L4 Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MBD3L4 Gene

No ASD Table

Relevant External Links for MBD3L4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MBD3L4 Gene

mRNA expression in normal human tissues for MBD3L4 Gene

SOURCE GeneReport for Unigene cluster for MBD3L4 Gene Hs.723810

genes like me logo Genes that share expression patterns with MBD3L4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MBD3L4 Gene

Orthologs for MBD3L4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MBD3L4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MBD3L3 35
  • 63.15 (n)
  • 50 (a)
-- 36
  • 49 (a)
(Canis familiaris)
Mammalia LOC100688619 35
  • 63.27 (n)
  • 52.04 (a)
-- 36
  • 35 (a)
(Mus musculus)
Mammalia Mbd3l2 35
  • 56.91 (n)
  • 39.51 (a)
Mbd3l2 36
  • 31 (a)
(Pan troglodytes)
Mammalia MBD3L2 35
  • 98.24 (n)
  • 96.63 (a)
-- 36
  • 96 (a)
-- 36
  • 97 (a)
-- 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Mbd3l2 35
  • 57.4 (n)
  • 43.41 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 23 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
(Gallus gallus)
Aves MBD3 36
  • 25 (a)
(Danio rerio)
Actinopterygii mbd3a 36
  • 22 (a)
mbd3b 36
  • 24 (a)
fruit fly
(Drosophila melanogaster)
Insecta MBD-like 36
  • 12 (a)
Species with no ortholog for MBD3L4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MBD3L4 Gene

Gene Tree for MBD3L4 (if available)
Gene Tree for MBD3L4 (if available)

Paralogs for MBD3L4 Gene

Paralogs for MBD3L4 Gene

(5) SIMAP similar genes for MBD3L4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MBD3L4: view

Variants for MBD3L4 Gene

Sequence variations from dbSNP and Humsavar for MBD3L4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs28421014 -- 7,037,273(+) GCCAC(A/G)GCGCC downstream-variant-500B
rs28630469 -- 7,037,322(+) TTAAC(A/G)GCCGG downstream-variant-500B
rs1651760 -- 7,039,971(-) AGGTG(G/T)TAATA intron-variant
rs74999478 -- 7,041,832(+) TGCAT(A/G)TGTAT upstream-variant-2KB
rs76699704 -- 7,042,076(+) TTCCT(G/T)TCTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MBD3L4 Gene

Variant ID Type Subtype PubMed ID
dgv136e55 CNV Gain 17911159
nsv517794 CNV Gain+Loss 19592680
dgv393n27 CNV Gain 19166990
esv2751809 CNV Gain 17911159
esv33729 CNV Gain+Loss 17666407
dgv3707n71 CNV Gain 21882294
dgv3708n71 CNV Gain 21882294
esv2751810 CNV Loss 17911159
nsv910954 CNV Loss 21882294
esv24114 CNV Gain+Loss 19812545
nsv821572 CNV Duplication 20802225
nsv510880 CNV Complex 20534489

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for MBD3L4 Gene

Disorders for MBD3L4 Gene

Relevant External Links for MBD3L4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MBD3L4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MBD3L4 Gene

Publications for MBD3L4 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 67

Products for MBD3L4 Gene

Sources for MBD3L4 Gene