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Aliases for MBD3L3 Gene

Aliases for MBD3L3 Gene

  • Methyl-CpG Binding Domain Protein 3 Like 3 2 3 5
  • MBD3-Like Protein 3 4

External Ids for MBD3L3 Gene

Previous GeneCards Identifiers for MBD3L3 Gene

  • GC19M007010

Summaries for MBD3L3 Gene

GeneCards Summary for MBD3L3 Gene

MBD3L3 (Methyl-CpG Binding Domain Protein 3 Like 3) is a Protein Coding gene. An important paralog of this gene is MBD3L4.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBD3L3 Gene

Genomics for MBD3L3 Gene

Regulatory Elements for MBD3L3 Gene

Enhancers for MBD3L3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G007068 1.1 ENCODE 0.7 +0.0 14 1.8 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 XAB2 ZNF557 ELAVL1 MBD3L3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MBD3L3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MBD3L3 Gene

Chromosome:
19
Start:
7,056,205 bp from pter
End:
7,069,615 bp from pter
Size:
13,411 bases
Orientation:
Minus strand

Genomic View for MBD3L3 Gene

Genes around MBD3L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MBD3L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MBD3L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MBD3L3 Gene

Proteins for MBD3L3 Gene

  • Protein details for MBD3L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NE82-MB3L3_HUMAN
    Recommended name:
    Putative methyl-CpG-binding domain protein 3-like 3
    Protein Accession:
    A6NE82

    Protein attributes for MBD3L3 Gene

    Size:
    208 amino acids
    Molecular mass:
    23095 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The MBD3L proteins are encoded by strongly repeated regions of the 19p13 chromosome. The exact number of functional copies is unclear, and some of them may represent pseudogenes.

neXtProt entry for MBD3L3 Gene

Post-translational modifications for MBD3L3 Gene

No Post-translational modifications

Other Protein References for MBD3L3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MBD3L3 Gene

Domains & Families for MBD3L3 Gene

Protein Domains for MBD3L3 Gene

Suggested Antigen Peptide Sequences for MBD3L3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NE82

UniProtKB/Swiss-Prot:

MB3L3_HUMAN :
  • Belongs to the MBD3L family.
Family:
  • Belongs to the MBD3L family.
genes like me logo Genes that share domains with MBD3L3: view

No data available for Gene Families for MBD3L3 Gene

Function for MBD3L3 Gene

Gene Ontology (GO) - Molecular Function for MBD3L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008327 methyl-CpG binding IBA --
genes like me logo Genes that share ontologies with MBD3L3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MBD3L3 Gene

Localization for MBD3L3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MBD3L3 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MBD3L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with MBD3L3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MBD3L3 Gene

Pathways & Interactions for MBD3L3 Gene

SuperPathways for MBD3L3 Gene

No Data Available

Interacting Proteins for MBD3L3 Gene

Gene Ontology (GO) - Biological Process for MBD3L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006346 methylation-dependent chromatin silencing IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MBD3L3: view

No data available for Pathways by source and SIGNOR curated interactions for MBD3L3 Gene

Drugs & Compounds for MBD3L3 Gene

No Compound Related Data Available

Transcripts for MBD3L3 Gene

mRNA/cDNA for MBD3L3 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MBD3L3 Gene

Methyl-CpG binding domain protein 3-like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MBD3L3 Gene

No ASD Table

Relevant External Links for MBD3L3 Gene

GeneLoc Exon Structure for
MBD3L3
ECgene alternative splicing isoforms for
MBD3L3

Expression for MBD3L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MBD3L3 Gene

mRNA differential expression in normal tissues according to GTEx for MBD3L3 Gene

This gene is overexpressed in Testis (x47.5).

NURSA nuclear receptor signaling pathways regulating expression of MBD3L3 Gene:

MBD3L3

SOURCE GeneReport for Unigene cluster for MBD3L3 Gene:

Hs.448960
genes like me logo Genes that share expression patterns with MBD3L3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MBD3L3 Gene

Orthologs for MBD3L3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MBD3L3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MBD3L2 34
  • 98.24 (n)
-- 35
  • 97 (a)
ManyToMany
-- 35
  • 96 (a)
ManyToMany
-- 35
  • 96 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC100688619 34
  • 66.49 (n)
-- 35
  • 35 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MBD3L3 34
  • 63.15 (n)
-- 35
  • 49 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mbd3l2 34
  • 57.24 (n)
mouse
(Mus musculus)
Mammalia Mbd3l2 34 35
  • 56.75 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 23 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 21 (a)
OneToMany
chicken
(Gallus gallus)
Aves MBD3 35
  • 25 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii mbd3b 35
  • 24 (a)
ManyToMany
mbd3a 35
  • 22 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta MBD-like 35
  • 12 (a)
OneToMany
Species where no ortholog for MBD3L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MBD3L3 Gene

ENSEMBL:
Gene Tree for MBD3L3 (if available)
TreeFam:
Gene Tree for MBD3L3 (if available)

Paralogs for MBD3L3 Gene

Paralogs for MBD3L3 Gene

(5) SIMAP similar genes for MBD3L3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MBD3L3: view

Variants for MBD3L3 Gene

Sequence variations from dbSNP and Humsavar for MBD3L3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1002081621 -- 7,056,684(+) GTAGG(C/T)GCAGA reference, missense
rs1002711986 -- 7,055,876(+) CCTGG(C/T)CAGCA downstream-variant-500B
rs1002733154 -- 7,055,737(+) CACAG(C/T)GCCAG downstream-variant-500B
rs1003469872 -- 7,058,474(+) AGAAC(A/G)ACCCA intron-variant
rs1005935452 -- 7,060,454(+) CTAGG(A/T)TCAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MBD3L3 Gene

Variant ID Type Subtype PubMed ID
dgv136e55 CNV gain 17911159
dgv1985e59 CNV duplication 20981092
dgv3421n100 CNV gain 25217958
dgv393n27 CNV gain 19166990
dgv6237n54 CNV gain 21841781
dgv6241n54 CNV gain 21841781
dgv6242n54 CNV gain 21841781
dgv6243n54 CNV loss 21841781
esv24114 CNV gain+loss 19812545
esv2751809 CNV gain 17911159
esv2751810 CNV loss 17911159
esv2760525 CNV gain 21179565
esv2762977 CNV gain+loss 21179565
esv33729 CNV gain+loss 17666407
esv3433434 CNV duplication 20981092
esv3574297 CNV gain 25503493
nsv1056752 CNV gain 25217958
nsv1061916 CNV gain 25217958
nsv1141328 CNV duplication 24896259
nsv1147556 CNV duplication 26484159
nsv517794 CNV gain+loss 19592680
nsv821572 CNV duplication 20802225
nsv960778 CNV duplication 23825009

Variation tolerance for MBD3L3 Gene

Gene Damage Index Score: 0.94; 19.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MBD3L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MBD3L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MBD3L3 Gene

Disorders for MBD3L3 Gene

Relevant External Links for MBD3L3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MBD3L3

No disorders were found for MBD3L3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MBD3L3 Gene

Publications for MBD3L3 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64

Products for MBD3L3 Gene

Sources for MBD3L3 Gene

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