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Aliases for MBD3L2 Gene

Aliases for MBD3L2 Gene

  • Methyl-CpG Binding Domain Protein 3 Like 2 2 3
  • Methyl-CpG Binding Domain Protein 3-Like 2 3 5
  • MBD3-Like Protein 2 3 4
  • CTB-25J19.1 3

External Ids for MBD3L2 Gene

Previous GeneCards Identifiers for MBD3L2 Gene

  • GC19P007109
  • GC19P006989
  • GC19P007000

Summaries for MBD3L2 Gene

Entrez Gene Summary for MBD3L2 Gene

  • This gene encodes a protein that is related to methyl-CpG-binding proteins but lacks the methyl-CpG binding domain. The protein has been found in germ cell tumors and some somatic tissues. [provided by RefSeq, Jul 2008]

GeneCards Summary for MBD3L2 Gene

MBD3L2 (Methyl-CpG Binding Domain Protein 3 Like 2) is a Protein Coding gene. Among its related pathways are Signaling events mediated by HDAC Class I. An important paralog of this gene is MBD3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBD3L2 Gene

Genomics for MBD3L2 Gene

Regulatory Elements for MBD3L2 Gene

Enhancers for MBD3L2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MBD3L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MBD3L2 Gene

7,049,321 bp from pter
7,051,735 bp from pter
2,415 bases
Plus strand

Genomic View for MBD3L2 Gene

Genes around MBD3L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MBD3L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MBD3L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MBD3L2 Gene

Proteins for MBD3L2 Gene

  • Protein details for MBD3L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyl-CpG-binding domain protein 3-like 2
    Protein Accession:

    Protein attributes for MBD3L2 Gene

    208 amino acids
    Molecular mass:
    22994 Da
    Quaternary structure:
    No Data Available
    • The MBD3L proteins are encoded by strongly repeated regions of the 19p13 chromosome. The exact number of functional copies is unclear, and some of them may represent pseudogenes.
    • Sequence=AAM28154.2; Type=Frameshift; Positions=204; Evidence={ECO:0000305};

neXtProt entry for MBD3L2 Gene

Proteomics data for MBD3L2 Gene at MOPED

Post-translational modifications for MBD3L2 Gene

No Post-translational modifications

Other Protein References for MBD3L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MBD3L2 Gene

Domains & Families for MBD3L2 Gene

Protein Domains for MBD3L2 Gene

Suggested Antigen Peptide Sequences for MBD3L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MBD3L family.
  • Belongs to the MBD3L family.
genes like me logo Genes that share domains with MBD3L2: view

No data available for Gene Families for MBD3L2 Gene

Function for MBD3L2 Gene

genes like me logo Genes that share phenotypes with MBD3L2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MBD3L2 Gene

Localization for MBD3L2 Gene

Subcellular locations from

Jensen Localization Image for MBD3L2 Gene COMPARTMENTS Subcellular localization image for MBD3L2 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MBD3L2 Gene

Pathways & Interactions for MBD3L2 Gene

genes like me logo Genes that share pathways with MBD3L2: view

Pathways by source for MBD3L2 Gene

1 BioSystems pathway for MBD3L2 Gene

Gene Ontology (GO) - Biological Process for MBD3L2 Gene


No data available for SIGNOR curated interactions for MBD3L2 Gene

Drugs & Compounds for MBD3L2 Gene

No Compound Related Data Available

Transcripts for MBD3L2 Gene

mRNA/cDNA for MBD3L2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MBD3L2 Gene

Methyl-CpG binding domain protein 3-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MBD3L2 Gene

No ASD Table

Relevant External Links for MBD3L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MBD3L2 Gene

mRNA expression in normal human tissues for MBD3L2 Gene

SOURCE GeneReport for Unigene cluster for MBD3L2 Gene Hs.567667

mRNA Expression by UniProt/SwissProt for MBD3L2 Gene

Tissue specificity: Detected at low levels in several somatic tissues. Highly expressed in the ovarian teratocarcinoma cell line PA-1.
genes like me logo Genes that share expression patterns with MBD3L2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MBD3L2 Gene

Orthologs for MBD3L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MBD3L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MBD3L3 35
  • 62.96 (n)
  • 50 (a)
-- 36
  • 49 (a)
(Canis familiaris)
Mammalia LOC100688619 35
  • 66.67 (n)
  • 55.96 (a)
-- 36
  • 35 (a)
(Mus musculus)
Mammalia Mbd3l2 35
  • 56.75 (n)
  • 39.02 (a)
Mbd3l2 36
  • 32 (a)
(Pan troglodytes)
Mammalia MBD3L2 35
  • 98.24 (n)
  • 96.63 (a)
-- 36
  • 94 (a)
-- 36
  • 93 (a)
-- 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Mbd3l2 35
  • 57.24 (n)
  • 42.93 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 24 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
(Gallus gallus)
Aves MBD3 36
  • 25 (a)
(Danio rerio)
Actinopterygii mbd3a 36
  • 22 (a)
mbd3b 36
  • 24 (a)
fruit fly
(Drosophila melanogaster)
Insecta MBD-like 36
  • 12 (a)
Species with no ortholog for MBD3L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MBD3L2 Gene

Gene Tree for MBD3L2 (if available)
Gene Tree for MBD3L2 (if available)

Paralogs for MBD3L2 Gene

Paralogs for MBD3L2 Gene

(6) SIMAP similar genes for MBD3L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MBD3L2: view

Variants for MBD3L2 Gene

Sequence variations from dbSNP and Humsavar for MBD3L2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1610556 -- 7,051,757(-) CAAAA(A/C)CATCC downstream-variant-500B
rs1610758 -- 7,051,597(-) CTGCC(C/T)GCCTG reference, missense
rs1613462 -- 7,051,614(-) TGACA(A/C/G/T)GTGGG reference, missense
rs1651750 -- 7,051,632(-) GCCCA(A/G)GACTG utr-variant-3-prime
rs1690418 -- 7,051,617(+) CAGGT(A/G)GATGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MBD3L2 Gene

Variant ID Type Subtype PubMed ID
dgv136e55 CNV Gain 17911159
nsv517794 CNV Gain+Loss 19592680
dgv393n27 CNV Gain 19166990
esv2751809 CNV Gain 17911159
esv33729 CNV Gain+Loss 17666407
dgv3708n71 CNV Gain 21882294
esv2751810 CNV Loss 17911159
esv24114 CNV Gain+Loss 19812545
nsv821572 CNV Duplication 20802225
nsv910955 CNV Gain 21882294
nsv482211 CNV Gain 20164927

Variation tolerance for MBD3L2 Gene

Gene Damage Index Score: 0.74; 15.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MBD3L2 Gene

Disorders for MBD3L2 Gene

Relevant External Links for MBD3L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MBD3L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MBD3L2 Gene

Publications for MBD3L2 Gene

  1. MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG- binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor. (PMID: 12504854) Jiang C.-L. … Pfeifer G.P. (Genomics 2002) 3 4 23 67
  2. MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing. (PMID: 15701600) Jin S.-G. … Pfeifer G.P. (J. Biol. Chem. 2005) 3 23
  3. Unique features of the anti-parallel, heterodimeric coiled-coil interaction between methyl-cytosine binding domain 2 (MBD2) homologues and GATA zinc finger domain containing 2A (GATAD2A/p66I+). (PMID: 23239876) Walavalkar N.M. … Williams D.C. (J. Biol. Chem. 2013) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MBD3L2 Gene

Sources for MBD3L2 Gene