MBD3L2 Gene
protein-coding GIFtS: 40
GCID: GC19P007049
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methyl-CpG binding domain protein 3-like 2
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Aliases
for MBD3L2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Methyl-CpG Binding Domain Protein 3-Like 21 2 | | MBD3-Like Protein 22 3 | | Methyl-CpG-Binding Domain Protein 3-Like 22 |
Export aliases for MBD3L2 gene to outside databasesPrevious GC identifers: GC19P007109 GC19P006989 GC19P007000 |
Summaries
for MBD3L2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MBD3L2:
This gene encodes a protein that is related to methyl-CpG-binding proteins but lacks the methyl-CpG binding domain. Theprotein has been found in germ cell tumors and some somatic tissues. (provided by RefSeq, Jul 2008)
|
Genomic Views
for MBD3L2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MBD3L2 gene promoter:
STAT1 STAT1beta STAT3 STAT1alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for MBD3L2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MBD3L2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.3MBD3L2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P007049: view genomic region
(about GC identifiers)
Start:
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7,049,350 bp from pter |
End:
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7,051,746 bp from pter |
Size:
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2,397 bases |
Orientation:
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plus strand |
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Proteins
for MBD3L2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MB3L2_HUMAN, Q8NHZ7 (See
protein sequence)Recommended Name: Methyl-CpG-binding domain protein 3-like 2 Size: 208 amino acids; 22994 Da
Miscellaneous: The MBD3L proteins are encoded by strongly repeated regions of the 19p13 chromosome. The exact number offunctional copies is unclear, and some of them may represent pseudogenes
Sequence caution: Sequence=AAM28154.2; Type=Frameshift; Positions=204;Explore the universe of human proteins at neXtProt for MBD3L2: NX_Q8NHZ7
MBD3L2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653215.2
ENSEMBL proteins: ENSP00000370800
Human Recombinant Protein Products:
MBD3L2 Antibody Products:
Assay Products for MBD3L2: |
Protein
Domains /
Families
for MBD3L2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MBD3L2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8NHZ7ProtoNet protein and cluster: Q8NHZ7 UniProtKB/Swiss-Prot: MB3L2_HUMAN, Q8NHZ7Similarity: Belongs to the MBD3L family |
Function
for MBD3L2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MBD3L2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MBD3L2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MBD3L2 |
Animal Models:
Mouse knock-out Mbd3l2tm1Gpp for MBD3L2
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Mbd3l2):
MBD3L2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MBD3L2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling events mediated by HDAC Class I | |
1  BioSystems Pathway for MBD3L2
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MBD3L2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/11 Interacting proteins for MBD3L2 (Q8NHZ73 ENSP000003708004) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
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Drugs & Compounds
for MBD3L2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MBD3L2
Search CenterWatch for drugs/clinical trials and news about MBD3L2 / MB3L2
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Transcripts
for MBD3L2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MBD3L2 gene: NM_144614.3 Unigene Cluster for MBD3L2: Methyl-CpG binding domain protein 3-like 2 Hs.567667 Unigene Representative Sequence: AF5039191 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000381393(uc010dvf.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MBD3L2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MBD3L2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MBD3L2 (NM_144614) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MBD3L2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MBD3L2 |
Additional cDNA sequence: AF503919.2 1 DOTS entry: DT.100016653 4 AceView cDNA sequences: BX113115 AI652740 AF503919 BE502398
GeneLoc Exon Structure
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Expression
for MBD3L2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MBD3L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MBD3L2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MBD3L2
SOURCE GeneReport for Unigene cluster: Hs.567667
UniProtKB/Swiss-Prot: MB3L2_HUMAN, Q8NHZ7Tissue specificity: Detected at low levels in several somatic tissues. Highly expressed in the ovarian teratocarcinomacell line PA-1
SABiosciences Custom PCR Arrays for MBD3L2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MBD3L2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MBD3L2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MBD3L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MBD3L2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MBD3L2 |
Orthologs
for MBD3L2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MBD3L2 gene from 3/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
Q5ZLX8_CHICK6 |
Uncharacterized protein |
19(a) |
1 → many |
28(1954899-1970475) |
zebrafish
(Danio rerio) |
Actinopterygii |
mbd3b6mbd3a6 |
methyl-CpG binding domain protein 3a |
22(a)20(a) |
many ↔ manymany ↔ many |
22(20610857-20627983) 2(57737888-57762598) |
fruit fly
(Drosophila melanogaster) |
Insecta |
MBD-like6 |
MBD-like |
12(a) |
1 → many |
3R(5385487-5387255) |
ENSEMBL Gene Tree for MBD3L2 (if available)
TreeFam Gene Tree for MBD3L2 (if available) |
Paralogs
for MBD3L2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MBD3L2 gene
- LOC7294581 2 MBD3L31 2 MBD3L51 2 MBD3L41 2 MBD22 MBD3L12 MBD32
6 SIMAP similar genes for MBD3L2 using alignment to 1 protein entry: MB3L2_HUMAN:MBD3L3 MBD3L4 MBD3L5 MBD3L1 NY-CO-41 MBD3
MBD3L2 for paralogs About GeneDecksing
|
Genomic Variants
for MBD3L2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MBD3L2 (7049350 - 7051746 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for MBD3L2
11 CNVs: 89048 8862 9301 78050 67451 34508 8863 7224 34616 50241 53678 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for MBD3L2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MBD3L2 for disorders About GeneDecksing
OMIM gene information: 607964
OMIM disorders: --
2  diseases for MBD3L2: About MalaCardsgerm cell tumor teratocarcinoma
Export disorders for MBD3L2 gene to outside databases
|
Publications
for MBD3L2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MBD3L2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MBD3L2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG- binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor. (PubMed id 12504854)1, 2, 9 Jiang C.-L.... Pfeifer G.P. (2002)
- MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing. (PubMed id 15701600)1, 9 Jin S.-G.... Pfeifer G.P. (2005)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for MBD3L2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MBD3L2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MBD3L2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MBD3L2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MBD3L2 gene:
Search GeneIP for patents involving MBD3L2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MBD3L2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MBD3L2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MBD3L2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MBD3L2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MBD3L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MBD3L2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MBD3L2 |
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 | | | MBD3L2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MBD3L2 |
|  |  |  | | | | Search ThermoFisher Antibodies for MBD3L2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MBD3L2 |
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