Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MBD3 Gene

protein-coding   GIFtS: 63
GCID: GC19M001576

Methyl-CpG Binding Domain Protein 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Methyl-CpG Binding Domain Protein 31 2
Methyl-CpG-Binding Domain Protein 32
Methyl-CpG-Binding Protein MBD33

External Ids:    HGNC: 69181   Entrez Gene: 536152   Ensembl: ENSG000000716557   OMIM: 6035735   UniProtKB: O959833   

Export aliases for MBD3 gene to outside databases

Previous GC identifers: GC19M001639 GC19M001516 GC19M001527 GC19M001350


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MBD3 Gene:
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian
development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a
methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing
nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is
not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2
with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this
gene. (provided by RefSeq, Jul 2013)

GeneCards Summary for MBD3 Gene: 
MBD3 (methyl-CpG binding domain protein 3) is a protein-coding gene. Diseases associated with MBD3 include subacute cutaneous lupus erythematosus, and cutaneous lupus erythematosus, and among its related super-pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Macrophage Differentiation and Growth Inhibition by METS. GO annotations related to this gene include chromatin binding and DNA binding. An important paralog of this gene is MBD3L4.

UniProtKB/Swiss-Prot: MBD3_HUMAN, O95983
Function: Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases. Acts as
transcriptional repressor and plays a role in gene silencing

Gene Wiki entry for MBD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MBD3 gene promoter:
         Elk-1   RP58   XBP-1   CBF-C   Egr-4   CBF-B   CBF-A   c-Myb   STAT3   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMBD3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MBD3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MBD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13

MBD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MBD3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M001576:  view genomic region     (about GC identifiers)

Start:
1,576,639 bp from pter      End:
1,592,882 bp from pter
Size:
16,244 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MBD3_HUMAN, O95983 (See protein sequence)
Recommended Name: Methyl-CpG-binding domain protein 3  
Size: 291 amino acids; 32844 Da
Subunit: Heterodimer with MBD2. Part of the NuRD and the MeCP1 complex. Binds HDAC1, MTA2, DNMT1, p66-alpha and
p66-beta
Subcellular location: Nucleus. Note=Nuclear, in discrete foci
Sequence caution: Sequence=AAH32443.1; Type=Erroneous initiation;
Secondary accessions: A8K4B7 D6W5Z2 Q6PIL9 Q6PJZ9 Q86XF4
Alternative splicing: 2 isoforms:  O95983-1   O95983-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MBD3: NX_O95983

Explore proteomics data for MBD3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95983

  • MBD3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MBD3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001268382.1  NP_001268383.1  

    ENSEMBL proteins: 
     ENSP00000464718   ENSP00000412302   ENSP00000466670   ENSP00000156825  

    Human Recombinant Protein Products for MBD3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MBD3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MBD3
    GenScript Custom Purified and Recombinant Proteins Services for MBD3
    Novus Biologicals MBD3 Proteins
    Novus Biologicals MBD3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for MBD3
    Cloud-Clone Corp. Proteins for MBD3 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin ----
    GO:0000792heterochromatin IEA--
    GO:0005634nucleus ----
    GO:0005737cytoplasm IEA--
    GO:0016581NuRD complex NAS17827154

    MBD3 for ontologies           About GeneDecksing



    MBD3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MBD3
    R&D Systems Antibodies for MBD3
    Cell Signaling Technology (CST) Antibodies for MBD3 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MBD3
    GenScript Custom Superior Antibodies Services for MBD3
    Novus Biologicals MBD3 Antibodies
    Abcam antibodies for MBD3
    Cloud-Clone Corp. Antibodies for MBD3 
    ThermoFisher Antibodies for MBD3
    LSBio Antibodies in human, mouse, rat for MBD3 

    Assay Products for MBD3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MBD3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MBD3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MBD3 
    Cloud-Clone Corp. CLIAs for MBD3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR025884 MeCpG-bd_2/3_C_dom
     IPR001739 Methyl_CpG_DNA-bd
     IPR016177 DNA-bd_integrase-typ

    Graphical View of Domain Structure for InterPro Entry O95983

    ProtoNet protein and cluster: O95983

    1 Blocks protein domain: IPB001739 Methyl-CpG binding

    UniProtKB/Swiss-Prot: MBD3_HUMAN, O95983
    Similarity: Contains 1 MBD (methyl-CpG-binding) domain


    MBD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MBD3_HUMAN, O95983
    Function: Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases. Acts as
    transcriptional repressor and plays a role in gene silencing

         Genatlas biochemistry entry for MBD3:
    methyl-CpG binding protein 3,expressed in somatic tissues,not binding methylated DNA in vitro or in vivo

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI12183469
         
    MBD3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MBD3:
     Decreased TP53 protein express 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mbd3):
     cellular  digestive/alimentary  homeostasis/metabolism  immune system  mortality/aging 
     tumorigenesis 

    MBD3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MBD3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MBD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MBD3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MBD3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MBD3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MBD3
    SwitchGear 3'UTR luciferase reporter plasmidMBD3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MBD3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MBD3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MBD3
    Sirion Biotech Customized adenovirus for overexpression of MBD3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MBD3 (see all 6)
    OriGene ORF clones in mouse, rat for MBD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MBD3 (NM_003926)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MBD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MBD3
    Sirion Biotech Customized lentivirus for stable overexpression of MBD3 
                         Customized lentivirus expression plasmids for stable overexpression of MBD3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MBD3
    Search LifeMap BioReagents cell lines for MBD3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MBD3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MBD3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation0.35
    2DNA Methylation and Transcriptional Repression
    DNA Methylation and Transcriptional Repression0.30
    3Signaling events mediated by HDAC Class I
    Signaling events mediated by HDAC Class I
    4Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MBD3
        Transcription Sin3 and NuRD in transcription regulation

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MBD3
        DNA Methylation and Transcriptional Repression

    1 Cell Signaling Technology (CST) Pathway for MBD3
        Chromatin Regulation / Acetylation

    1 GeneGo (Thomson Reuters) Pathway for MBD3
        Transcription Sin3 and NuRD in transcription regulation

    1 BioSystems Pathway for MBD3
        Signaling events mediated by HDAC Class I



    MBD3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MBD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/659 Interacting proteins for MBD3 (O959831, 2, 3 ENSP000001568254) via UniProtKB, MINT, STRING, and/or I2D (see all 659)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX5P178441, 2, 3, ENSP000002257924EBI-1783068,EBI-351962 MINT-7945693 I2D: score=3 STRING: ENSP00000225792
    MTA2O947762, 3, ENSP000002788234MINT-7945693 MINT-7943765 I2D: score=5 STRING: ENSP00000278823
    HDAC1Q135472, 3, ENSP000003626494MINT-7945693 MINT-7943765 I2D: score=4 STRING: ENSP00000362649
    HDAC2Q927692, 3, ENSP000003813314MINT-7945693 MINT-7943765 I2D: score=2 STRING: ENSP00000381331
    AURKAO149652, 3, ENSP000002169114MINT-7945693 I2D: score=3 STRING: ENSP00000216911
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0006346methylation-dependent chromatin silencing IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0009888tissue development IEA--

    MBD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MBD3

    Search CenterWatch for drugs/clinical trials and news about MBD3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MBD3 gene (3 alternative transcripts): 
    NM_001281453.1  NM_001281454.1  NM_003926.5  

    Unigene Cluster for MBD3:

    Methyl-CpG binding domain protein 3
    Hs.178728  [show with all ESTs]
    Unigene Representative Sequence: NM_003926
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000590550 ENST00000434436(uc002ltk.3) ENST00000592012 ENST00000585903
    ENST00000585967 ENST00000589064 ENST00000592361 ENST00000592965 ENST00000156825(uc002ltj.3 uc002ltl.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MBD3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MBD3
    SwitchGear 3'UTR luciferase reporter plasmidMBD3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MBD3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MBD3
    Clone
    Products:
         
    OriGene clones in human, mouse for MBD3 (see all 6)
    OriGene ORF clones in mouse, rat for MBD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MBD3 (NM_003926)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MBD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MBD3
    Sirion Biotech Customized lentivirus for stable overexpression of MBD3 
                         Customized lentivirus expression plasmids for stable overexpression of MBD3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MBD3
    OriGene qSTAR qPCR primer pairs in human, mouse for MBD3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MBD3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MBD3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MBD3

    Additional mRNA sequence: 

    AF072247.1 AK001474.1 AK021532.1 AK290882.1 BC000872.1 BC009372.1 BC009438.1 BC018784.1 
    BC032443.1 BC043619.1 X58233.1 

    21 DOTS entries:

    DT.100034143  DT.65284492  DT.101978021  DT.100819819  DT.100819817  DT.100806804  DT.100819820  DT.121471043 
    DT.75138848  DT.100819822  DT.91823425  DT.100797144  DT.95211055  DT.100708644  DT.121470970  DT.86836938 
    DT.92443555  DT.95210998  DT.100037882  DT.91997741  DT.97859994 

    24/851 AceView cDNA sequences (see all 851):

    C05577 BX091611 BI522628 BU147329 AL046370 AA542930 AA365166 CR605565 
    AA715239 BQ957443 AA588259 AA706804 F01596 BQ015370 BU161905 T07968 
    BF432417 AW161860 BU526798 BC003594 AW163325 AI468144 AJ708979 BF590589 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MBD3 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c
    SP1:              -     -     -     -     -           -                 -                                             
    SP2:                    -     -     -     -           -                 -                                             
    SP3:                                                  -                 -                                             
    SP4:                                                  -                 -                                             
    SP5:                          -     -     -           -                 -                                             


    ECgene alternative splicing isoforms for MBD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MBD3 expression in normal human tissues (normalized intensities)      MBD3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGGATGTG
    MBD3 Expression
    About this image


    MBD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             testis ; cells in seminiferus ducts   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Breast (Uncategorized)    fully expand to see all 2 entries
             breast ; myoepithelial cells   

    See MBD3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MBD3

    SOURCE GeneReport for Unigene cluster: Hs.178728
        SABiosciences Expression via Pathway-Focused PCR Array including MBD3: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MBD3
    OriGene qSTAR qPCR primer pairs in human, mouse for MBD3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MBD3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MBD3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MBD3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MBD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MBD3 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mbd31 , 5 methyl-CpG binding domain protein 31, 5 88.57(n)1
    95.76(a)1
      10 (39.72 cM)5
    171921  NM_013595.21  NP_038623.11 
     803925395 
    chicken
    (Gallus gallus)
    Aves MBD31 methyl-CpG binding domain protein 3 80.97(n)
    91.85(a)
      770153  NM_001079751.1  NP_001073219.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia MBD32 methyl-CpG binding protein MBD3 long form 76.44(n)    AF170346.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.284072 Danio rerio methyl-CpG binding protein 3a (mbd3a) mRNA, more 79.83(n)    AY398379.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MBD-like6
    MBD-like
    27(a)
    1 → many
    3R(5385487-5387255)


    ENSEMBL Gene Tree for MBD3 (if available)
    TreeFam Gene Tree for MBD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MBD3 gene
    MBD3L42  MBD22  MBD3L32  MBD3L12  MBD3L52  MBD3L22  
    6 SIMAP similar genes for MBD3 using alignment to 2 protein entries:     MBD3_HUMAN (see all proteins):
    MBD2    DKFZp586O0821    NY-CO-41    MBD3L1    MBD3L2    MBD3L5

    MBD3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/479 SNPs in MBD3 are shown (see all 479)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1393288381,2
    C--1368599(+) AATTAC/G/TGTTTT 1 -- us2k10--------
    rs1179372481,2
    C,F--1505032(+) TGCAGC/TGGCTG 1 -- ds50011Minor allele frequency- T:0.04NA 120
    rs1866021161,2
    --1505110(+) GGAGCA/GGTGCT 1 -- ds50010--------
    rs1508797321,2
    --1505205(+) GGGCAC/TGGCCC 1 -- ds50010--------
    rs1918208601,2
    --1505206(+) GGCACA/GGCCCT 1 -- ds50010--------
    rs1840397941,2
    --1505223(+) CAGATA/GCCCAG 1 -- ds50010--------
    rs1393332551,2
    --1505232(+) AGGCCA/GGCCTG 1 -- ds50010--------
    rs1158448191,2
    --1505322(+) ACACCA/GCTTTC 1 -- ds50010--------
    rs1445284011,2
    --1505392(+) CGCACC/TGAACT 1 -- ds50010--------
    rs1129808841,2
    C,F--1505393(+) GCACCG/CAACTC 1 -- ds50012Minor allele frequency- C:0.02CSA WA 120

    HapMap Linkage Disequilibrium report for MBD3 (1576639 - 1592882 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for MBD3 (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3589n71CNV Loss21882294
    dgv3608n71CNV Loss21882294
    dgv3607n71CNV Loss21882294
    dgv3601n71CNV Loss21882294
    dgv3611n71CNV Loss21882294
    nsv910292CNV Loss21882294
    nsv910540CNV Loss21882294
    dgv3610n71CNV Loss21882294
    dgv3603n71CNV Loss21882294
    nsv910499CNV Loss21882294


    Human Gene Mutation Database (HGMD): MBD3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MBD3
    DNA2.0 Custom Variant and Variant Library Synthesis for MBD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603573    OMIM disorders: --

    11 diseases for MBD3:    About MalaCards
    subacute cutaneous lupus erythematosus    cutaneous lupus erythematosus    silver-russell syndrome    keratitis
    dermatomyositis    lupus erythematosus    systemic lupus erythematosus    lung cancer
    prostate cancer    prostatitis    breast cancer


    MBD3 for disorders           About GeneDecksing


    Export disorders for MBD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MBD3 gene, integrated from 9 sources (see all 87):
    (articles sorted by number of sources associating them with MBD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a family of mammalian methyl- CpG binding proteins. (PubMed id 9774669)1, 2, 3, 9 Hendrich B. and Bird A. (1998)
    2. Genomic structure and chromosomal mapping of the murine and human mbd1, mbd2, mbd3, and mbd4 genes. (PubMed id 10441743)1, 3, 9 Hendrich B.... Bird A. (1999)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Identification and functional characterization of the p66/p68 components of the MeCP1 complex. (PubMed id 11756549)1, 2 Feng Q....Zhang Y. (2002)
    7. The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. (PubMed id 12124384)1, 2 Saito M. and Ishikawa F. (2002)
    8. Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3. (PubMed id 12183469)1, 2 Brackertz M.... Renkawitz R. (2002)
    9. Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. (PubMed id 11102443)1, 2 Humphrey G.W....Howard B.H. (2001)
    10. MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase. (PubMed id 10947852)1, 2 Tatematsu K.... Ishikawa F. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 53615 HGNC: 6918 AceView: MBD3andUQCR Ensembl:ENSG00000071655 euGenes: HUgn53615
    ECgene: MBD3 H-InvDB: MBD3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MBD3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MBD3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MBD3 gene:
    Search GeneIP for patents involving MBD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of MBD3
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for MBD3 (MBD3)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MBD3  
     OriGene qPCR primer pairs and template standards for MBD3   OriGene Protein Over-expression Lysate for MBD3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MBD3  
     OriGene qSTAR qPCR primer pairs in human, mouse for MBD3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MBD3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MBD3   OriGene Custom Protein Services for MBD3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MBD3
     QIAGEN SeqTarget long-range PCR primers for resequencing MBD3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MBD3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MBD3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MBD3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MBD3
     GenScript Custom Purified and Recombinant Proteins Services for MBD3 GenScript cDNA clones with any tag delivered in your preferred vector for MBD3
     GenScript Custom Assay Services for MBD3 GenScript Custom Superior Antibodies Services for MBD3
     GenScript Custom overexpressing Cell Line Services for MBD3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for MBD3 

     Regulatory tfbs in MBD3 promoter
     Search Chromatin IP Primers for MBD3
     RT2 qPCR Primer Assay in human, mouse, rat MBD3
     GNC Network for MBD3
     SABiosciences PCR Arrays including human, mouse, rat MBD3
     Search Tocris compounds for MBD3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MBD3 antibodies
     MBD3 proteins
     MBD3 lysates
     Antibodies for MBD3
     See all of Abcam's Antibodies, Kits and Proteins for MBD3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for MBD3




     Proteins for MBD3
     Antibodies for MBD3
     ELISAs for MBD3
     CLIAs for MBD3
     Search LifeMap BioReagents cell lines for MBD3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MBD3
     SwitchGear 3'UTR luciferase reporter plasmids for MBD3
     SwitchGear Promoter luciferase reporter plasmids for MBD3
     ThermoFisher Antibodies for MBD3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MBD3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MBD3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MBD3
    Customized:
     lentivirus for stable overexpression of MBD3
     lentivirus expression plasmids for stable overexpression of MBD3
     adenovirus for overexpression of MBD3
     LSBio Antibodies in human, mouse, rat for MBD3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MBD3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4