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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MBD2 Gene

protein-coding   GIFtS: 64
GCID: GC18M051615

methyl-CpG binding domain protein 2
 Explore 41 diseases affiliated with
MBD2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MBD2    

Aliases
for MBD2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Methyl-CpG Binding Domain Protein 21 2     Methyl-CpG-Binding Domain Protein 22
DMTase2 3     Demethylase3
NY-CO-412     Methyl-CpG-Binding Protein MBD23
Demethylase3     

External Ids:    HGNC: 69171   Entrez Gene: 89322   Ensembl: ENSG000001340467   OMIM: 6035475   UniProtKB: Q9UBB53   

Export aliases for MBD2 gene to outside databases

Previous GC identifers: GC18M051851 GC18M049932 GC18M049934 GC18M048535


Summaries
for MBD2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MBD2:
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development.
Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each
of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding
specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters.
The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal.
It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation
causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: MBD2_HUMAN, Q9UBB5
Function: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG
dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as
transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and
GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters

Gene Wiki entry for MBD2 (Methyl-CpG-binding domain protein 2)


Genomic Views
for MBD2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010966.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MBD2 gene promoter:
         GATA-3   p53   AP-1   Sp1   Pax-2   Pax-2a   YY1   S8   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MBD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MBD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MBD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21   Ensembl cytogenetic band:  18q21.2   HGNC cytogenetic band: 18q21

MBD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MBD2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M051615:  view genomic region     (about GC identifiers)

Start:
 51,679,079 bp from pter      End:
 51,751,158 bp from pter
Size:
 72,080 bases      Orientation:
 minus strand

Proteins
for MBD2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MBD2_HUMAN, Q9UBB5 (See protein sequence)
Recommended Name: Methyl-CpG-binding domain protein 2  
Size: 411 amino acids; 43255 Da
Subunit: Heterodimer with MBD3. Component of the MeCP1 complex that contains HDAC1 and HDAC2. Binds DNMT1, MIZF, GPN1,
SIN3A, GATAD2A/p66-alpha and GATAD2B/p66-beta. Interacts with DHX9
Subcellular location: Nucleus. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase
Caution: Functional studies (PubMed:10050851, PubMed:10950960 and PubMed:12665568) have used a C-terminal fragment of
isoform 1 which has been described originally as isoform MBD2b (PubMed:9774669) but cannot however be proven by
supporting cDNA sequences
1 PDB 3D structure from and Proteopedia for MBD2:
2L2L (3D)    
Secondary accessions: O95242 Q9UIS8
Alternative splicing: 2 isoforms:  Q9UBB5-1   Q9UBB5-3   (Incomplete sequence)

Explore the universe of human proteins at neXtProt for MBD2: NX_Q9UBB5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UBB5

    • MBD2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_003918.1  NP_056647.1  

    ENSEMBL proteins: 
     ENSP00000256429   ENSP00000462393   ENSP00000381435   ENSP00000464554  

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    Uscn Proteins for MBD2

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118histone deacetylase complex IEA--
    GO:0000785chromatin ----
    GO:0000792heterochromatin IEA--
    GO:0005634nucleus NAS10441743
    GO:0005737cytoplasm IEA--


    MBD2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MBD2

    Protein Domains /
    Families
    for MBD2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MBD2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR025884 MeCpG-bd_2/3_C_dom
     IPR001739 Methyl_CpG_DNA-bd
     IPR016177 DNA-bd_integrase-typ

    Graphical View of Domain Structure for InterPro Entry Q9UBB5

    ProtoNet protein and cluster: Q9UBB5

    1 Blocks protein family: IPB001739 Methyl-CpG binding

    UniProtKB/Swiss-Prot: MBD2_HUMAN, Q9UBB5
    Similarity: Contains 1 MBD (methyl-CpG-binding) domain


    Function
    for MBD2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MBD2_HUMAN, Q9UBB5
    Function: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG
    dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as
    transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and
    GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters

         Genatlas biochemistry entry for MBD2:
    methyl-CpG binding protein 2,demethylase,40kDa,binding methylated DNA,histone deacetylase complex,widely
    expressed,underexpressed at the early stage of colorectal and stomach carcinogenesis

    miRNA
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    hsa-miR-520f hsa-miR-106a hsa-miR-128 hsa-miR-138-2* hsa-miR-519a hsa-miR-130b hsa-miR-4273 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmid: MBD2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for MBD2

    In Situ Assay
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    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003696satellite DNA binding TAS9774669
    GO:0003729mRNA binding IEA--
    GO:0005515protein binding IPI12183469


    MBD2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MBD2:
     Increased cell number in G2M,  

    Animal Models:
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mbd2):
     behavior/neurological  mortality/aging  reproductive system  tumorigenesis 

    MBD2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MBD2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcription_Sin3 and NuRD in transcription regulation
    		Transcription_Sin3 and NuRD in transcription regulation1.00
    		Transcription Sin3 and NuRD in transcription regulation0.96
    2Signaling events mediated by HDAC Class I
    		Signaling events mediated by HDAC Class I1.00
    3DNA Methylation and Transcriptional Repression
    		DNA Methylation and Transcriptional Repression1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for MBD2
        Transcription Sin3 and NuRD in transcription regulation

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MBD2
        DNA Methylation and Transcriptional Repression

    1 GeneGo (Thomson Reuters) Pathway for MBD2
        Transcription Sin3 and NuRD in transcription regulation

    1 BioSystems Pathway for MBD2 
        Signaling events mediated by HDAC Class I



    MBD2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MBD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/70 Interacting proteins for MBD2 (Q9UBB53 ENSP000002564294) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MBD3L2Q8NHZ73, ENSP000003708004I2D: score=2 STRING: ENSP00000370800
    MBD3O959833, ENSP000001568254I2D: score=4 STRING: ENSP00000156825
    RBBP4Q090283, ENSP000003625924I2D: score=4 STRING: ENSP00000362592
    GPN1Q9HCN43, ENSP000002647184I2D: score=3 STRING: ENSP00000264718
    LOC729458Q8NHZ73I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0030177positive regulation of Wnt receptor signaling pathway IEA--
    GO:0042127regulation of cell proliferation IEA--
    GO:0042711maternal behavior IEA--


    MBD2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MBD2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MBD2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MBD2

    2 HMDB Compounds for MBD2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cytosine4-Amino-2(1H)-pyrimidinone (see all 6)71-30-7--
    10/17 Novoseek chemical compound relationships for MBD2 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    3-methylcytosine 78.7 2 15380096 (1)
    5-aza-2'deoxycytidine 72.9 4 16537832 (1), 17464181 (1), 19557157 (1)
    5-methylcytosine 67.1 1 15112265 (1)
    lysine 55.5 12 16603238 (2), 17668288 (2), 20005732 (1), 20164337 (1) (see all 7)
    amine 47 1 20101264 (1)
    hpaii 46.1 1 14530963 (1)
    dimethylnitrosamine 45.8 4 9498284 (1), 8900414 (1), 9185616 (1)
    mcpg 45.3 4 12124384 (1), 10050851 (1)
    cytosine 44.4 6 19557157 (2), 11406558 (1), 10050851 (1)
    s-adenosylmethionine 38.3 15 17688412 (2), 12676953 (2), 16982764 (1)

    Search CenterWatch for drugs/clinical trials and news about MBD2 

    Transcripts
    for MBD2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MBD2 gene (2 alternative transcripts): 
    NM_003927.4  NM_015832.4  

    Unigene Cluster for MBD2:

    Methyl-CpG binding domain protein 2
    Hs.25674  [show with all ESTs]
    Unigene Representative Sequence: NM_003927
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256429(uc002lfg.2) ENST00000579025 ENST00000578272 ENST00000398398(uc002lfh.2)
    ENST00000583046

    miRNA
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    hsa-miR-520f hsa-miR-106a hsa-miR-128 hsa-miR-138-2* hsa-miR-519a hsa-miR-130b hsa-miR-4273 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmid: MBD2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MBD2 (see all 7)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF039701.1 AF072242.1 AF072246.1 AF072252.1 AL110266.1 BC032638.1 

    9 DOTS entries:

    DT.417161  DT.207769  DT.102830938  DT.75162746  DT.91757680  DT.100787745  DT.100787751  DT.91757685 
    DT.95285248 

    24/231 AceView cDNA sequences (see all 231):

    AA599696 AI538314 BM726114 AA290863 CR603954 CR615628 CA942909 AF072242 
    AW406193 AF072246 AI358361 BF593814 NM_003927 BM888491 BQ018993 AI055997 
    AA814881 AA932620 NM_015832 BE385660 CR615715 BU674700 BG402778 BG538171 

    GeneLoc Exon Structure


    Expression
    for MBD2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MBD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTATTTTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MBD2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartAtrioventricular CanalHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MBD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MBD2

    SOURCE GeneReport for Unigene cluster: Hs.25674

    UniProtKB/Swiss-Prot: MBD2_HUMAN, Q9UBB5
    Tissue specificity: Highly expressed in brain, heart, kidney, stomach, testis and placenta

        SABiosciences Expression via Pathway-Focused PCR Arrays including MBD2: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MBD2

    Orthologs
    for MBD2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MBD2 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MBD21 methyl-CpG binding domain protein 2 69.29(n)
    82.99(a)    		   497269  NM_001012403.1  NP_001012403.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MBD26
    		 --
    		 95(a)
    		 1 ↔ 1
    		 GL343213.1(30316-98535)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.216152 Xenopus laevis mRNA for methyl-CpG binding protein more 83.15(n)    AB061672.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mbd21 methyl-CpG binding domain protein 2 69.59(n)
    78.88(a)    		   337105  NM_212768.1  NP_997933.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta MBD-like1 , 3 methyl-CpG binding3
    CG8208-PA1    		 35(a)3
    49.92(n)1
    45.12(a)1    		   85D243
    411511  NM_141650.21  NP_649907.11 
    wheat
    (Triticum aestivum)    		 Liliopsida CA633185.12   -- 70.47(n)    CA633185.1 


    ENSEMBL Gene Tree for MBD2 (if available)
    TreeFam Gene Tree for MBD2 (if available) 

    Paralogs
    for MBD2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MBD2 gene
    MBD3L42  LOC7294582  MBD3L32  MBD32  MBD3L12  MBD3L52  MBD3L22  
    2 SIMAP similar genes for MBD2 using alignment to 2 protein entries:     MBD2_HUMAN (see all proteins):
    NY-CO-41    MBD3

    MBD2 for paralogs           About GeneDecksing



    Genomic Variants
    for MBD2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1170 NCBI SNPs in MBD2 are shown (see all 1170)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs779162391,2
    		F,--48532906(+) GTTTTC/TCCATC 1 -- ds50011Minor allele frequency- T:0.03EA 120
    rs750968471,2
    		F,--48533137(+) GGACCC/ACACCC 1 -- ds50011Minor allele frequency- A:0.03EA 120
    rs745086051,2
    		C,--48533660(+) TTTTAC/TGGTGC 1 -- ut310--------
    rs1162817881,2
    		C,F,--48534071(+) GCAAAC/TAGTTA 1 -- ut311Minor allele frequency- T:0.02WA 118
    rs789263711,2
    		--48534098(+) TGCCAG/ATCACT 1 -- ut311Minor allele frequency- A:0.01EA 120
    rs99638691,2
    		C,F,H,--48534345(+) ATAGCG/AACAAT 1 -- ut315Minor allele frequency- A:0.02NS EA WA 538
    rs774287011,2
    		F,--48534991(+) GTATAT/CTGGGA 1 -- ut311Minor allele frequency- C:0.02EA 120
    rs776207551,2
    		--48535415(+) TCATCC/TACCAG 1 -- ut311Minor allele frequency- T:0.01NA 120
    rs116655601,2
    		C,H--48535537(+) CAGCAG/ACCCAA 1 -- ut314Minor allele frequency- A:0.00NS EA 420
    rs126083721,2
    		H--48535557(+) CAAACC/TTAGCT 1 -- ut314Minor allele frequency- T:0.00NS EA 420

    HapMap Linkage Disequilibrium report for MBD2 (51679079 - 51751158 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MBD2
         1 CNV: 39218

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MBD2
    DNA2.0 Custom Variant and Variant Library Synthesis for MBD2

    Disorders / Diseases
    for MBD2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MBD2 for disorders           About GeneDecksing

    OMIM gene information: 603547    OMIM disorders: --

    20/41 diseases for MBD2 (see all 41):    About MalaCards
    diffuse large b-cell lymphoma    b-cell lymphomas    klatskin's tumor    systemic lupus erythematosus
    lupus erythematosus    chronic lymphocytic leukemia    bladder carcinoma    epithelial ovarian cancer
    lymphocytic leukemia    follicular lymphoma    kaposi's sarcoma    ovarian cancer
    stomach cancer    keratitis    rheumatoid arthritis    colorectal adenoma and carcinoma
    dermatomyositis    gastric cancer    carcinoma    nephropathy

    1 disease from the University of Copenhagen DISEASES database for MBD2:
    Klatskin's tumor

    10/12 Novoseek disease relationships for MBD2 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 36.9 15 12646234 (3), 14688029 (3), 11710831 (2), 18931530 (1) (see all 7)
    prostate cancer 27.4 17 11870882 (5), 16786000 (2), 12646234 (2), 18048344 (1) (see all 5)
    tumors 17.6 21 18931530 (3), 11965543 (3), 15112265 (2), 17070797 (1) (see all 11)
    breast cancer 15.9 12 12543808 (5), 16322686 (1), 16168120 (1), 11965543 (1)
    bladder carcinoma 10.4 2 15112265 (2)
    leukemia 0 1 15467427 (1)
    cancer lung 0 1 12776203 (1)
    gastric cancer 0 5 15526354 (3), 10544038 (1)
    colon carcinoma 0 1 15823509 (1)
    adenocarcinoma 0 2 11471858 (1), 11710831 (1)

    Genetic Association Database (GAD): MBD2
    Human Genome Epidemiology (HuGE) Navigator: MBD2 (10 documents)

    Export disorders for MBD2 gene to outside databases

    Publications
    for MBD2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MBD2 gene, integrated from 9 sources (see all 221):
    (articles sorted by number of sources associating them with MBD2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure and chromosomal mapping of the murine and human mbd1, mbd2, mbd3, and mbd4 genes. (PubMed id 10441743)1, 2, 3, 9 Hendrich B.... Bird A. (1999)
    2. Identification and characterization of a family of mammalian methyl- CpG binding proteins. (PubMed id 9774669)1, 2, 3, 9 Hendrich B. and Bird A. (1998)
    3. Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2. (PubMed id 11553631)1, 2, 9 Sekimata M.... Homma Y. (2001)
    4. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. (PubMed id 10471499)1, 2, 9 Ng H.-H.... Bird A. (1999)
    5. MBDin, a novel MBD2-interacting protein, relieves MBD2 repression potential and reactivates transcription from methylated promoters. (PubMed id 12588985)1, 2, 9 Lembo F....Chiariotti L. (2003)
    6. Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3. (PubMed id 12183469)1, 2, 9 Brackertz M.... Renkawitz R. (2002)
    7. p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction. (PubMed id 16415179)1, 2, 9 Brackertz M....Renkawitz R. (2006)
    8. Genotypes and haplotypes of the methyl-CpG-binding domain 2 modify breast cancer risk dependent upon menopausal status. (PubMed id 16168120)1, 4, 9 Zhu Y....Zheng T. (2005)
    9. MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase. (PubMed id 10947852)1, 2, 9 Tatematsu K.... Ishikawa F. (2000)
    10. A mammalian protein with specific demethylase activity for mCpG DNA. (PubMed id 10050851)1, 2, 9 Bhattacharya S.K.... Szyf M. (1999)

    External Searches for MBD2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    Genome Databases showing MBD2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8932 HGNC: 6917 AceView: MBD2 Ensembl:ENSG00000134046 euGenes: HUgn8932
    ECgene: MBD2 H-InvDB: MBD2

    Other Databases showing MBD2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MBD2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MBD2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MBD2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MBD2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MBD2 gene:
    Search GeneIP for patents involving MBD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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