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Aliases for MBD2 Gene

Aliases for MBD2 Gene

  • Methyl-CpG Binding Domain Protein 2 2 3
  • Demethylase 3 4
  • DMTase 3 4
  • Methyl-CpG-Binding Domain Protein 2 3
  • Methyl-CpG-Binding Protein MBD2 4
  • NY-CO-41 3

External Ids for MBD2 Gene

Summaries for MBD2 Gene

Entrez Gene Summary for MBD2 Gene

  • DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for MBD2 Gene

MBD2 (Methyl-CpG Binding Domain Protein 2) is a Protein Coding gene. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Gene Expression. GO annotations related to this gene include chromatin binding and mRNA binding. An important paralog of this gene is MBD3.

UniProtKB/Swiss-Prot for MBD2 Gene

  • Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.

Gene Wiki entry for MBD2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBD2 Gene

Genomics for MBD2 Gene

Genomic Location for MBD2 Gene

Start:
54,151,601 bp from pter
End:
54,224,788 bp from pter
Size:
73,188 bases
Orientation:
Minus strand

Genomic View for MBD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MBD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MBD2 Gene

Regulatory Elements for MBD2 Gene

Proteins for MBD2 Gene

  • Protein details for MBD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBB5-MBD2_HUMAN
    Recommended name:
    Methyl-CpG-binding domain protein 2
    Protein Accession:
    Q9UBB5
    Secondary Accessions:
    • O95242
    • Q9UIS8

    Protein attributes for MBD2 Gene

    Size:
    411 amino acids
    Molecular mass:
    43255 Da
    Quaternary structure:
    • Heterodimer with MBD3. Component of the MeCP1 complex that contains HDAC1 and HDAC2. Binds DNMT1, MIZF, GPN1, SIN3A, GATAD2A/p66-alpha and GATAD2B/p66-beta. Interacts with DHX9.

    Three dimensional structures from OCA and Proteopedia for MBD2 Gene

    Alternative splice isoforms for MBD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MBD2 Gene

Proteomics data for MBD2 Gene at MOPED

Post-translational modifications for MBD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MBD2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MBD2 Gene

Domains for MBD2 Gene

Protein Domains for MBD2 Gene

UniProtKB/Swiss-Prot:

MBD2_HUMAN
Domain:
  • Contains 1 MBD (methyl-CpG-binding) domain.:
    • Q9UBB5
genes like me logo Genes that share domains with MBD2: view

No data available for Gene Families for MBD2 Gene

Function for MBD2 Gene

Molecular function for MBD2 Gene

GENATLAS Biochemistry: methyl-CpG binding protein 2,demethylase,40kDa,binding methylated DNA,histone deacetylase complex,widely expressed,underexpressed at the early stage of colorectal and stomach carcinogenesis
UniProtKB/Swiss-Prot Function: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.

Gene Ontology (GO) - Molecular Function for MBD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 16217013
GO:0000980 contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding IDA 16217013
GO:0003677 DNA binding --
GO:0003682 chromatin binding --
GO:0003696 satellite DNA binding TAS 9774669
genes like me logo Genes that share ontologies with MBD2: view

Phenotypes for MBD2 Gene

genes like me logo Genes that share phenotypes with MBD2: view

miRNA for MBD2 Gene

miRTarBase miRNAs that target MBD2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MBD2 Gene

Localization for MBD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MBD2 Gene

Nucleus. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MBD2 Gene COMPARTMENTS Subcellular localization image for MBD2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MBD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IEA --
GO:0000785 chromatin --
GO:0000790 nuclear chromatin IDA 16217013
GO:0000792 heterochromatin IEA --
GO:0005634 nucleus NAS 10441743
genes like me logo Genes that share ontologies with MBD2: view

Pathways for MBD2 Gene

genes like me logo Genes that share pathways with MBD2: view

Gene Ontology (GO) - Biological Process for MBD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0010467 gene expression TAS --
GO:0030177 positive regulation of Wnt signaling pathway IEA --
GO:0040029 regulation of gene expression, epigenetic TAS --
genes like me logo Genes that share ontologies with MBD2: view

Compounds for MBD2 Gene

(2) HMDB Compounds for MBD2 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4
Cytosine
  • 4-Amino-2(1H)-pyrimidinone
71-30-7

(17) Novoseek inferred chemical compound relationships for MBD2 Gene

Compound -log(P) Hits PubMed IDs
3-methylcytosine 78.7 1
5-aza-2deoxycytidine 72.9 3
5-methylcytosine 67.1 1
lysine 55.5 9
amine 47 1
genes like me logo Genes that share compounds with MBD2: view

Transcripts for MBD2 Gene

Unigene Clusters for MBD2 Gene

Methyl-CpG binding domain protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MBD2 Gene

No ASD Table

Relevant External Links for MBD2 Gene

GeneLoc Exon Structure for
MBD2
ECgene alternative splicing isoforms for
MBD2

Expression for MBD2 Gene

mRNA expression in normal human tissues for MBD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MBD2 Gene

SOURCE GeneReport for Unigene cluster for MBD2 Gene Hs.25674

mRNA Expression by UniProt/SwissProt for MBD2 Gene

Q9UBB5-MBD2_HUMAN
Tissue specificity: Highly expressed in brain, heart, kidney, stomach, testis and placenta.
genes like me logo Genes that share expressions with MBD2: view

Orthologs for MBD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MBD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MBD2 36
  • 98.78 (n)
  • 97.57 (a)
MBD2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MBD2 36
  • 93.47 (n)
  • 96.98 (a)
MBD2 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MBD2 36
  • 96.25 (n)
  • 99.13 (a)
MBD2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mbd2 36
  • 91.32 (n)
  • 95.62 (a)
Mbd2 16
Mbd2 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MBD2 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MBD2 37
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mbd2 36
  • 89.92 (n)
  • 93.9 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 67 (a)
ManyToMany
MBD2 36
  • 69.29 (n)
  • 82.99 (a)
lizard
(Anolis carolinensis)
Reptilia MBD2 37
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21615 36
zebrafish
(Danio rerio)
Actinopterygii mbd2 36
  • 69.59 (n)
  • 78.88 (a)
mbd2 37
  • 84 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003982 36
  • 50.55 (n)
  • 50.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta MBD-like 36
  • 52.4 (n)
  • 49.77 (a)
MBD-like 37
  • 24 (a)
OneToMany
MBD-like 38
  • 35 (a)
Species with no ortholog for MBD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MBD2 Gene

ENSEMBL:
Gene Tree for MBD2 (if available)
TreeFam:
Gene Tree for MBD2 (if available)

Paralogs for MBD2 Gene

Paralogs for MBD2 Gene

Selected SIMAP similar genes for MBD2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MBD2: view

Variants for MBD2 Gene

Sequence variations from dbSNP and Humsavar for MBD2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs7614 -- 54,154,874(-) CCATC(A/G)TCACT utr-variant-3-prime
rs140691 -- 54,204,938(-) TATCT(C/T)ACATC intron-variant
rs473734 -- 54,226,277(+) aatac(A/C)aaaat upstream-variant-2KB
rs475368 -- 54,172,411(+) CTAAC(A/G)ATGGT intron-variant
rs479852 -- 54,171,942(+) CAAAA(A/G)CTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MBD2 Gene

Variant ID Type Subtype PubMed ID
esv993042 CNV Deletion 20482838

Relevant External Links for MBD2 Gene

HapMap Linkage Disequilibrium report
MBD2

Disorders for MBD2 Gene

(1) University of Copenhagen DISEASES for MBD2 Gene

(12) Novoseek inferred disease relationships for MBD2 Gene

Disease -log(P) Hits PubMed IDs
cancer 36.9 12
prostate cancer 27.4 11
tumors 17.6 16
breast cancer 15.9 8
bladder carcinoma 10.4 2

Relevant External Links for MBD2

Genetic Association Database (GAD)
MBD2
Human Genome Epidemiology (HuGE) Navigator
MBD2
genes like me logo Genes that share disorders with MBD2: view

No data available for UniProtKB/Swiss-Prot for MBD2 Gene

Publications for MBD2 Gene

  1. Identification and characterization of a family of mammalian methyl- CpG binding proteins. (PMID: 9774669) Hendrich B. … Bird A. (Mol. Cell. Biol. 1998) 2 3 4 23
  2. Genomic structure and chromosomal mapping of the murine and human mbd1, mbd2, mbd3, and mbd4 genes. (PMID: 10441743) Hendrich B. … Bird A. (Mamm. Genome 1999) 2 3 4 23
  3. MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase. (PMID: 10947852) Tatematsu K. … Ishikawa F. (Genes Cells 2000) 3 4 23
  4. Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. (PMID: 11102443) Humphrey G.W. … Howard B.H. (J. Biol. Chem. 2001) 3 4 23
  5. Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2. (PMID: 11553631) Sekimata M. … Homma Y. (J. Biol. Chem. 2001) 3 4 23

Products for MBD2 Gene

  • Addgene plasmids for MBD2

Sources for MBD2 Gene

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