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Aliases for MB21D2 Gene

Aliases for MB21D2 Gene

  • Mab-21 Domain Containing 2 2 3 5
  • Mab-21 Domain-Containing Protein 2 3 4
  • C3orf59 3 4
  • Chromosome 3 Open Reading Frame 59 2
  • Protein MB21D2 3

External Ids for MB21D2 Gene

Previous HGNC Symbols for MB21D2 Gene

  • C3orf59

Previous GeneCards Identifiers for MB21D2 Gene

  • GC03M192515

Summaries for MB21D2 Gene

GeneCards Summary for MB21D2 Gene

MB21D2 (Mab-21 Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include protein complex binding. An important paralog of this gene is TMEM102.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MB21D2 Gene

Genomics for MB21D2 Gene

Regulatory Elements for MB21D2 Gene

Enhancers for MB21D2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MB21D2 on UCSC Golden Path with GeneCards custom track

Promoters for MB21D2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MB21D2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MB21D2 Gene

Chromosome:
3
Start:
192,796,815 bp from pter
End:
192,918,161 bp from pter
Size:
121,347 bases
Orientation:
Minus strand

Genomic View for MB21D2 Gene

Genes around MB21D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MB21D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MB21D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MB21D2 Gene

Proteins for MB21D2 Gene

  • Protein details for MB21D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYB1-M21D2_HUMAN
    Recommended name:
    Protein MB21D2
    Protein Accession:
    Q8IYB1
    Secondary Accessions:
    • Q86VD8

    Protein attributes for MB21D2 Gene

    Size:
    491 amino acids
    Molecular mass:
    55800 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH13123.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH45582.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MB21D2 Gene

Post-translational modifications for MB21D2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MB21D2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MB21D2 Gene

Domains & Families for MB21D2 Gene

Protein Domains for MB21D2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MB21D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYB1

UniProtKB/Swiss-Prot:

M21D2_HUMAN :
  • Belongs to the mab-21 family.
Family:
  • Belongs to the mab-21 family.
genes like me logo Genes that share domains with MB21D2: view

No data available for Gene Families for MB21D2 Gene

Function for MB21D2 Gene

Gene Ontology (GO) - Molecular Function for MB21D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032403 protein complex binding IDA 23209302
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with MB21D2: view
genes like me logo Genes that share phenotypes with MB21D2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MB21D2 Gene

Localization for MB21D2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MB21D2 Gene COMPARTMENTS Subcellular localization image for MB21D2 gene
Compartment Confidence
cytosol 3

Gene Ontology (GO) - Cellular Components for MB21D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005913 cell-cell adherens junction IDA 25468996
genes like me logo Genes that share ontologies with MB21D2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MB21D2 Gene

Pathways & Interactions for MB21D2 Gene

SuperPathways for MB21D2 Gene

No Data Available

Interacting Proteins for MB21D2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000376246%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000376246 Q8IYB1-M21D2_HUMAN for MB21D2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for MB21D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with MB21D2: view

No data available for Pathways by source and SIGNOR curated interactions for MB21D2 Gene

Drugs & Compounds for MB21D2 Gene

No Compound Related Data Available

Transcripts for MB21D2 Gene

mRNA/cDNA for MB21D2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(81) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MB21D2 Gene

Mab-21 domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MB21D2 Gene

No ASD Table

Relevant External Links for MB21D2 Gene

GeneLoc Exon Structure for
MB21D2
ECgene alternative splicing isoforms for
MB21D2

Expression for MB21D2 Gene

mRNA expression in normal human tissues for MB21D2 Gene

Protein differential expression in normal tissues from HIPED for MB21D2 Gene

This gene is overexpressed in Plasma (27.6), Placenta (14.6), Testis (11.1), and Fetal Brain (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MB21D2 Gene



Protein tissue co-expression partners for MB21D2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MB21D2 Gene:

MB21D2

SOURCE GeneReport for Unigene cluster for MB21D2 Gene:

Hs.151443
genes like me logo Genes that share expression patterns with MB21D2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MB21D2 Gene

Orthologs for MB21D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MB21D2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MB21D2 34
  • 93.82 (n)
  • 99.8 (a)
MB21D2 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MB21D2 34
  • 93.21 (n)
  • 100 (a)
MB21D2 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mb21d2 34
  • 89.61 (n)
  • 98.57 (a)
Mb21d2 16
Mb21d2 35
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MB21D2 34
  • 99.66 (n)
  • 99.8 (a)
MB21D2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mb21d2 34
  • 88.87 (n)
  • 98.37 (a)
oppossum
(Monodelphis domestica)
Mammalia MB21D2 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MB21D2 35
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves MB21D2 34
  • 83.91 (n)
  • 97.96 (a)
MB21D2 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mb21d2 34
  • 78.66 (n)
  • 95.5 (a)
Str.16029 34
zebrafish
(Danio rerio)
Actinopterygii mb21d2 34
  • 73.76 (n)
  • 86.09 (a)
mb21d2a 35
  • 76 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
ManyToMany
CSA.9655 35
  • 47 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14604 34
Species where no ortholog for MB21D2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MB21D2 Gene

ENSEMBL:
Gene Tree for MB21D2 (if available)
TreeFam:
Gene Tree for MB21D2 (if available)

Paralogs for MB21D2 Gene

Paralogs for MB21D2 Gene

genes like me logo Genes that share paralogs with MB21D2: view

Variants for MB21D2 Gene

Sequence variations from dbSNP and Humsavar for MB21D2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs924917 -- 192,807,802(+) ACACC(A/G)CCCCC intron-variant
rs937588 -- 192,846,150(-) AAGAT(A/T)GGACA intron-variant
rs937589 -- 192,846,126(-) TTTCA(A/G)TGACT intron-variant
rs950376 -- 192,891,395(+) ATAAT(C/T)AATGT intron-variant
rs2986 -- 192,813,413(+) CTTCA(A/G)GACTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MB21D2 Gene

Variant ID Type Subtype PubMed ID
dgv308n21 CNV loss 19592680
dgv5010n100 CNV gain 25217958
dgv847n67 CNV loss 20364138
dgv8809n54 CNV gain 21841781
esv2662415 CNV deletion 23128226
esv2674918 CNV deletion 23128226
esv2760768 CNV loss 21179565
esv3599159 CNV loss 21293372
esv3599161 CNV loss 21293372
esv3599162 CNV loss 21293372
esv3599163 CNV loss 21293372
esv3599164 CNV loss 21293372
esv997039 CNV deletion 20482838
nsv1007014 CNV gain 25217958
nsv1074651 CNV deletion 25765185
nsv1117049 CNV deletion 24896259
nsv1150889 CNV deletion 26484159
nsv437906 CNV loss 16468122
nsv461124 CNV gain 19166990
nsv471138 CNV gain 18288195
nsv476711 CNV novel sequence insertion 20440878
nsv592907 CNV loss 21841781

Variation tolerance for MB21D2 Gene

Residual Variation Intolerance Score: 63.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MB21D2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MB21D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MB21D2 Gene

Disorders for MB21D2 Gene

Relevant External Links for MB21D2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MB21D2

No disorders were found for MB21D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MB21D2 Gene

Publications for MB21D2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 65
  4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. (PMID: 25468996) Guo Z. … Zaidel-Bar R. (Sci Signal 2014) 3 65
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65

Products for MB21D2 Gene

Sources for MB21D2 Gene

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