MB21D2 Gene
protein-coding GIFtS: 36
GCID: GC03M192515
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|
Mab-21 domain containing 2(Previous name: chromosome 3 open reading frame 59 )
(Previous symbol: C3orf59)
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Aliases
for MB21D2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mab-21 Domain Containing 21 2 | | C3orf591 2 3 | | Mab-21 Domain-Containing Protein 22 3 | | Chromosome 3 Open Reading Frame 591 | | Protein MB21D22 |
Export aliases for MB21D2 gene to outside databases |
Summaries
for MB21D2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for MB21D2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MB21D2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MB21D2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MB21D2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q29 Ensembl cytogenetic band: 3q29 HGNC cytogenetic band: 3q28-q29MB21D2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M192515: view genomic region
(about GC identifiers)
Start:
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192,514,604 bp from pter |
End:
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192,635,950 bp from pter |
Size:
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121,347 bases |
Orientation:
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minus strand |
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Proteins
for MB21D2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: M21D2_HUMAN, Q8IYB1 (See
protein sequence)Recommended Name: Protein MB21D2 Size: 491 amino acids; 55800 Da
Sequence caution: Sequence=AAH13123.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAH45582.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q86VD8Explore the universe of human proteins at neXtProt for MB21D2: NX_Q8IYB1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IYB1
MB21D2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_848591.2
ENSEMBL proteins: ENSP00000376246
Human Recombinant Protein Products:
MB21D2 Antibody Products:
Assay Products for MB21D2: |
Protein
Domains /
Families
for MB21D2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MB21D2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IYB1ProtoNet protein and cluster: Q8IYB1 UniProtKB/Swiss-Prot: M21D2_HUMAN, Q8IYB1Similarity: Belongs to the mab-21 family |
Function
for MB21D2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MB21D2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MB21D2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MB21D2 (NM_178496) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MB21D2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MB21D2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MB21D2 |
|
Pathways & Interactions
for MB21D2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MB21D2
|
Drugs & Compounds
for MB21D2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MB21D2
Search CenterWatch for drugs/clinical trials and news about MB21D2 / M21D2
|
Transcripts
for MB21D2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MB21D2 gene: NM_178496.3 Unigene Cluster for MB21D2: Mab-21 domain containing 2 Hs.151443 [show with all ESTs]Unigene Representative Sequence: NM_1784961 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000392452(uc011bsp.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MB21D2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MB21D2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MB21D2 (NM_178496) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MB21D2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MB21D2 |
Additional cDNA sequence: AK002025.1 AK056276.1 AK290447.1 BC013123.1 BC036194.1 BC045582.1 BX648517.1 1 DOTS entry: DT.213796 24/81 AceView cDNA sequences (see all 81): BQ948224 AA988254 F10449 AK056276 AI149569 CB117293 BC013123 AI423882 BQ050771 AW072173 F02312 BP871966 CR604177 AU137765 AA861296 CF264814 AA994880 BX106162 BP872465 AA368234 R95134 AK002025 CA774832 BG679242
GeneLoc Exon Structure
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Expression
for MB21D2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MB21D2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAATTAATG
About this image
See MB21D2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MB21D2
SOURCE GeneReport for Unigene cluster: Hs.151443
SABiosciences Custom PCR Arrays for MB21D2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MB21D2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MB21D2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MB21D2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MB21D2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MB21D2 |
Orthologs
for MB21D2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MB21D2 gene from 4/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mb21d21 , 5 |
RIKEN cDNA 1600021P15 gene5
Mab-21 domain containing 21 |
89.61(n)1
98.57(a)1 |
|
16 (19.71 cM)5
2397961 NM_177718.31 NP_808386.21
288261765 |
chicken
(Gallus gallus) |
Aves |
MB21D21 |
Mab-21 domain containing 2 |
83.91(n)
97.96(a) |
|
424905 XM_422716.3 XP_422716.2 |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.160292 |
Transcribed sequences |
77.94(n) |
|
BX754579.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
mb21d21 |
Mab-21 domain containing 2 |
73.89(n)
86.3(a) |
|
556707 XM_679576.2 XP_684668.2 |
ENSEMBL Gene Tree for MB21D2 (if available)
TreeFam Gene Tree for MB21D2 (if available) |
Paralogs
for MB21D2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MB21D2 gene
- TMEM1022
MB21D2 for paralogs About GeneDecksing
|
Genomic Variants
for MB21D2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MB21D2 (192514604 - 192635950 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MB21D2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MB21D2 |
|
Disorders
/ Diseases
for MB21D2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for MB21D2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MB21D2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MB21D2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
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External Searches for MB21D2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MB21D2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MB21D2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MB21D2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MB21D2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MB21D2 gene:
Search GeneIP for patents involving MB21D2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MB21D2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MB21D2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MB21D2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MB21D2 | | | OriGene Protein Over-expression Lysate for MB21D2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MB21D2 | | OriGene 3'-UTR Clone for MB21D2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MB21D2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MB21D2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MB21D2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MB21D2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MB21D2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MB21D2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MB21D2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MB21D2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MB21D2 |
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| | | | Search Tocris compounds for MB21D2 |
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 | | | MB21D2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MB21D2 |
|  |  |  | | | | Search ThermoFisher Antibodies for MB21D2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MB21D2 |
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