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Aliases for MB21D2 Gene

Aliases for MB21D2 Gene

  • Mab-21 Domain Containing 2 2 3 5
  • Mab-21 Domain-Containing Protein 2 3 4
  • C3orf59 3 4
  • Chromosome 3 Open Reading Frame 59 2

External Ids for MB21D2 Gene

Previous HGNC Symbols for MB21D2 Gene

  • C3orf59

Previous GeneCards Identifiers for MB21D2 Gene

  • GC03M192515

Summaries for MB21D2 Gene

GeneCards Summary for MB21D2 Gene

MB21D2 (Mab-21 Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include protein complex binding. An important paralog of this gene is TMEM102.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MB21D2 Gene

Genomics for MB21D2 Gene

Regulatory Elements for MB21D2 Gene

Enhancers for MB21D2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MB21D2 on UCSC Golden Path with GeneCards custom track

Promoters for MB21D2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MB21D2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MB21D2 Gene

192,796,815 bp from pter
192,918,161 bp from pter
121,347 bases
Minus strand

Genomic View for MB21D2 Gene

Genes around MB21D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MB21D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MB21D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MB21D2 Gene

Proteins for MB21D2 Gene

  • Protein details for MB21D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein MB21D2
    Protein Accession:
    Secondary Accessions:
    • Q86VD8

    Protein attributes for MB21D2 Gene

    491 amino acids
    Molecular mass:
    55800 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH13123.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH45582.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MB21D2 Gene

Proteomics data for MB21D2 Gene at MOPED

Post-translational modifications for MB21D2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MB21D2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MB21D2 Gene

Domains & Families for MB21D2 Gene

Protein Domains for MB21D2 Gene


Suggested Antigen Peptide Sequences for MB21D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mab-21 family.
  • Belongs to the mab-21 family.
genes like me logo Genes that share domains with MB21D2: view

No data available for Gene Families for MB21D2 Gene

Function for MB21D2 Gene

genes like me logo Genes that share phenotypes with MB21D2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MB21D2 Gene

Localization for MB21D2 Gene

Subcellular locations from

Jensen Localization Image for MB21D2 Gene COMPARTMENTS Subcellular localization image for MB21D2 gene
Compartment Confidence
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MB21D2 Gene

Pathways & Interactions for MB21D2 Gene

SuperPathways for MB21D2 Gene

No Data Available

Interacting Proteins for MB21D2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000376246 for MB21D2 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for MB21D2 Gene


No data available for Pathways by source and SIGNOR curated interactions for MB21D2 Gene

Drugs & Compounds for MB21D2 Gene

No Compound Related Data Available

Transcripts for MB21D2 Gene

mRNA/cDNA for MB21D2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(81) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MB21D2 Gene

Mab-21 domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MB21D2 Gene

No ASD Table

Relevant External Links for MB21D2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MB21D2 Gene

mRNA expression in normal human tissues for MB21D2 Gene

Protein differential expression in normal tissues from HIPED for MB21D2 Gene

This gene is overexpressed in Plasma (27.6), Placenta (14.6), Testis (11.1), and Fetal Brain (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MB21D2 Gene

SOURCE GeneReport for Unigene cluster for MB21D2 Gene Hs.151443

genes like me logo Genes that share expression patterns with MB21D2: view

Protein tissue co-expression partners for MB21D2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MB21D2 Gene

Orthologs for MB21D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MB21D2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MB21D2 35
  • 93.82 (n)
  • 99.8 (a)
MB21D2 36
  • 99 (a)
(Canis familiaris)
Mammalia MB21D2 35
  • 93.21 (n)
  • 100 (a)
MB21D2 36
  • 100 (a)
(Mus musculus)
Mammalia Mb21d2 35
  • 89.61 (n)
  • 98.57 (a)
Mb21d2 16
Mb21d2 36
  • 99 (a)
(Pan troglodytes)
Mammalia MB21D2 35
  • 99.66 (n)
  • 99.8 (a)
MB21D2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mb21d2 35
  • 88.87 (n)
  • 98.37 (a)
(Monodelphis domestica)
Mammalia MB21D2 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia MB21D2 36
  • 98 (a)
(Gallus gallus)
Aves MB21D2 35
  • 83.91 (n)
  • 97.96 (a)
MB21D2 36
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mb21d2 35
  • 78.66 (n)
  • 95.5 (a)
Str.16029 35
(Danio rerio)
Actinopterygii mb21d2 35
  • 73.76 (n)
  • 86.09 (a)
mb21d2a 36
  • 76 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14604 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
CSA.9655 36
  • 47 (a)
Species with no ortholog for MB21D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MB21D2 Gene

Gene Tree for MB21D2 (if available)
Gene Tree for MB21D2 (if available)

Paralogs for MB21D2 Gene

Paralogs for MB21D2 Gene

genes like me logo Genes that share paralogs with MB21D2: view

Variants for MB21D2 Gene

Sequence variations from dbSNP and Humsavar for MB21D2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2986 -- 192,813,413(+) CTTCA(A/G)GACTA intron-variant
rs3299 -- 192,876,855(-) GCCCT(A/G)AGGAG intron-variant
rs7507 -- 192,797,104(-) GCTCC(C/T)TGTTT utr-variant-3-prime
rs10908 -- 192,797,967(-) TTTTT(C/T)TTATG utr-variant-3-prime
rs12481 -- 192,797,261(-) ACTTA(C/T)AATCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MB21D2 Gene

Variant ID Type Subtype PubMed ID
nsv471138 CNV Gain 18288195
nsv878122 CNV Gain 21882294
nsv461124 CNV Gain 19166990
esv997039 CNV Deletion 20482838
esv2662415 CNV Deletion 23128226
dgv847n67 CNV Loss 20364138
esv2674918 CNV Deletion 23128226
nsv437906 CNV Loss 16468122
dgv308n21 CNV Loss 19592680

Variation tolerance for MB21D2 Gene

Residual Variation Intolerance Score: 63.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MB21D2 Gene

Disorders for MB21D2 Gene

Relevant External Links for MB21D2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MB21D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MB21D2 Gene

Publications for MB21D2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  4. KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. (PMID: 23209302) Ahmed S.M. … Angers S. (J. Cell Biol. 2012) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for MB21D2 Gene

Sources for MB21D2 Gene