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Aliases for MB21D2 Gene

Aliases for MB21D2 Gene

  • Mab-21 Domain Containing 2 2 3
  • Mab-21 Domain-Containing Protein 2 3 4
  • C3orf59 3 4
  • Chromosome 3 Open Reading Frame 59 2

External Ids for MB21D2 Gene

Previous HGNC Symbols for MB21D2 Gene

  • C3orf59

Previous GeneCards Identifiers for MB21D2 Gene

  • GC03M192515

Summaries for MB21D2 Gene

GeneCards Summary for MB21D2 Gene

MB21D2 (Mab-21 Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include protein complex binding. An important paralog of this gene is TMEM102.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MB21D2 Gene

Genomics for MB21D2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MB21D2 Gene

Chromosome:
3
Start:
192,796,815 bp from pter
End:
192,918,161 bp from pter
Size:
121,347 bases
Orientation:
Minus strand

Genomic View for MB21D2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MB21D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MB21D2 Gene

No data available for Regulatory Elements for MB21D2 Gene

Proteins for MB21D2 Gene

  • Protein details for MB21D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYB1-M21D2_HUMAN
    Recommended name:
    Protein MB21D2
    Protein Accession:
    Q8IYB1
    Secondary Accessions:
    • Q86VD8

    Protein attributes for MB21D2 Gene

    Size:
    491 amino acids
    Molecular mass:
    55800 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH13123.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH45582.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MB21D2 Gene

Proteomics data for MB21D2 Gene at MOPED

Post-translational modifications for MB21D2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MB21D2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MB21D2 Gene

Domains & Families for MB21D2 Gene

Protein Domains for MB21D2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MB21D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYB1

UniProtKB/Swiss-Prot:

M21D2_HUMAN :
  • Belongs to the mab-21 family.
Family:
  • Belongs to the mab-21 family.
genes like me logo Genes that share domains with MB21D2: view

No data available for Gene Families for MB21D2 Gene

Function for MB21D2 Gene

Gene Ontology (GO) - Molecular Function for MB21D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032403 protein complex binding IDA 23209302
genes like me logo Genes that share ontologies with MB21D2: view
genes like me logo Genes that share phenotypes with MB21D2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MB21D2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MB21D2 Gene

Localization for MB21D2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MB21D2 Gene COMPARTMENTS Subcellular localization image for MB21D2 gene
Compartment Confidence
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MB21D2 Gene

Pathways & Interactions for MB21D2 Gene

SuperPathways for MB21D2 Gene

No Data Available

Interacting Proteins for MB21D2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000376246%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000376246 for MB21D2 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for MB21D2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MB21D2 Gene

Drugs & Compounds for MB21D2 Gene

No Compound Related Data Available

Transcripts for MB21D2 Gene

mRNA/cDNA for MB21D2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(81) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MB21D2 Gene

Mab-21 domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MB21D2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MB21D2 Gene

No ASD Table

Relevant External Links for MB21D2 Gene

GeneLoc Exon Structure for
MB21D2
ECgene alternative splicing isoforms for
MB21D2

Expression for MB21D2 Gene

mRNA expression in normal human tissues for MB21D2 Gene

Protein differential expression in normal tissues from HIPED for MB21D2 Gene

This gene is overexpressed in Plasma (27.6), Placenta (14.6), Testis (11.1), and Fetal Brain (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MB21D2 Gene



SOURCE GeneReport for Unigene cluster for MB21D2 Gene Hs.151443

genes like me logo Genes that share expression patterns with MB21D2: view

Protein tissue co-expression partners for MB21D2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MB21D2 Gene

Orthologs for MB21D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MB21D2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MB21D2 35
  • 93.82 (n)
  • 99.8 (a)
MB21D2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MB21D2 35
  • 93.21 (n)
  • 100 (a)
MB21D2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mb21d2 35
  • 89.61 (n)
  • 98.57 (a)
Mb21d2 16
Mb21d2 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MB21D2 35
  • 99.66 (n)
  • 99.8 (a)
MB21D2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mb21d2 35
  • 88.87 (n)
  • 98.37 (a)
oppossum
(Monodelphis domestica)
Mammalia MB21D2 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MB21D2 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves MB21D2 35
  • 83.91 (n)
  • 97.96 (a)
MB21D2 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mb21d2 35
  • 78.66 (n)
  • 95.5 (a)
Str.16029 35
zebrafish
(Danio rerio)
Actinopterygii mb21d2 35
  • 73.76 (n)
  • 86.09 (a)
mb21d2a 36
  • 76 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14604 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
ManyToMany
CSA.9655 36
  • 47 (a)
ManyToMany
Species with no ortholog for MB21D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MB21D2 Gene

ENSEMBL:
Gene Tree for MB21D2 (if available)
TreeFam:
Gene Tree for MB21D2 (if available)

Paralogs for MB21D2 Gene

Paralogs for MB21D2 Gene

genes like me logo Genes that share paralogs with MB21D2: view

Variants for MB21D2 Gene

Sequence variations from dbSNP and Humsavar for MB21D2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2986 -- 192,813,413(+) CTTCA(A/G)GACTA intron-variant
rs3299 -- 192,876,855(-) GCCCT(A/G)AGGAG intron-variant
rs7507 -- 192,797,104(-) GCTCC(C/T)TGTTT utr-variant-3-prime
rs10908 -- 192,797,967(-) TTTTT(C/T)TTATG utr-variant-3-prime
rs12481 -- 192,797,261(-) ACTTA(C/T)AATCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MB21D2 Gene

Variant ID Type Subtype PubMed ID
nsv471138 CNV Gain 18288195
nsv878122 CNV Gain 21882294
nsv461124 CNV Gain 19166990
esv997039 CNV Deletion 20482838
esv2662415 CNV Deletion 23128226
dgv847n67 CNV Loss 20364138
esv2674918 CNV Deletion 23128226
nsv437906 CNV Loss 16468122
dgv308n21 CNV Loss 19592680

Variation tolerance for MB21D2 Gene

Residual Variation Intolerance Score: 63.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MB21D2 Gene

HapMap Linkage Disequilibrium report
MB21D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MB21D2 Gene

Disorders for MB21D2 Gene

Relevant External Links for MB21D2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MB21D2
genes like me logo Genes that share disorders with MB21D2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MB21D2 Gene

Publications for MB21D2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  3. KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. (PMID: 23209302) Ahmed S.M. … Angers S. (J. Cell Biol. 2012) 67
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 67

Products for MB21D2 Gene

Sources for MB21D2 Gene

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