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MB Gene

protein-coding   GIFtS: 63
GCID: GC22M036002

Myoglobin

  See MB-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
myoglobin1 2
PVALB2
myoglobgin2

External Ids:    HGNC: 69151   Entrez Gene: 41512   Ensembl: ENSG000001981257   OMIM: 1600005   UniProtKB: P021443   

Export aliases for MB gene to outside databases

Previous GC identifers: GC22M032646 GC22M034274 GC22M034327 GC22M018967


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MB Gene:
This gene encodes a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The encoded
protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of
oxygen. At least three alternatively spliced transcript variants encoding the same protein have been reported.
(provided by RefSeq, Jul 2008)

GeneCards Summary for MB Gene:
MB (myoglobin) is a protein-coding gene. Diseases associated with MB include anuria, and malignant triton tumor. GO annotations related to this gene include iron ion binding and oxygen binding. An important paralog of this gene is CYGB.

UniProtKB/Swiss-Prot: MYG_HUMAN, P02144
Function: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles

Gene Wiki entry for MB (Myoglobin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MB gene promoter:
         AP-1   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MB promoter sequence
   Search Chromatin IP Primers for MB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q13.1

MB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MB gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M036002:  view genomic region     (about GC identifiers)

Start:
36,002,811 bp from pter      End:
36,033,998 bp from pter
Size:
31,188 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MYG_HUMAN, P02144 (See protein sequence)
Recommended Name: Myoglobin  
Size: 154 amino acids; 17184 Da
1 PDB 3D structure from and Proteopedia for MB:
3RGK (3D)    
Secondary accessions: Q52H51 Q5THY7

Explore the universe of human proteins at neXtProt for MB: NX_P02144

Explore proteomics data for MB at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_005359.1  NP_976311.1  NP_976312.1  

    ENSEMBL proteins: 
     ENSP00000386060   ENSP00000380489   ENSP00000384239   ENSP00000403351   ENSP00000413309  
     ENSP00000397944   ENSP00000389263   ENSP00000414243   ENSP00000352835   ENSP00000380491  

    MB Human Recombinant Protein Products:

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    GenScript Custom Purified and Recombinant Proteins Services for MB
    Novus Biologicals MB Proteins
    Novus Biologicals MB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MB
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MB 

     
    antibodies-online proteins for MB (90 products) 

     
    antibodies-online peptides for MB

    MB Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for MB
    antibodies-online antibodies for MB (245 products) 

    MB Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Luminex Assays for MB (Myoglobin)
    GenScript Custom Assay Services for MB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for MB 
    antibodies-online kits for MB (56 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR012292 Globin_dom
     IPR009050 Globin-like
     IPR002335 Myoglobin
     IPR000971 Globin

    Graphical View of Domain Structure for InterPro Entry P02144

    ProtoNet protein and cluster: P02144

    1 Blocks protein domain: IPB002335 Myoglobin signature

    UniProtKB/Swiss-Prot: MYG_HUMAN, P02144
    Similarity: Belongs to the globin family


    Find genes that share domains with MB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MYG_HUMAN, P02144
    Function: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles

         Genatlas biochemistry entry for MB:
    myoglobin,17.5kDa,muscle oxygen-carrying hemoprotein,non covalently

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005344oxygen transporter activity IEA--
    GO:0005506iron ion binding IEA--
    GO:0019825oxygen binding IEA--
    GO:0020037heme binding IEA--
         
    Find genes that share ontologies with MB           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mb):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hematopoietic system 
     homeostasis/metabolism  mortality/aging  muscle  respiratory system 

    Find genes that share phenotypes with MB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MB: Mbtm1Jsc Mbtm1Wlm

       genOway: Develop your customized and physiologically relevant rodent model for MB

    miRNA
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    miRTarBase miRNAs that target MB:
    hsa-mir-26b-5p (MIRT029607)

    Block miRNA regulation of human, mouse, rat MB using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidMB 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MB

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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MB

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    mitochondrion3
    extracellular2
    nucleus2
    plasma membrane2
    endoplasmic reticulum1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MB About    
    See pathways by source

    SuperPathContained pathways About
    1Effects of nitric oxide
    Effects of nitric oxide


    1 BioSystems Pathway for MB
        Effects of nitric oxide



        Pathway & Disease-focused RT2 Profiler PCR Arrays including MB: 
              Oxidative Stress in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for MB (P021443 ENSP000003528354) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT15P190123I2D: score=1 
    MTUS2Q5JR593I2D: score=1 
    PSMC6P623333I2D: score=1 
    PSMD4P550363I2D: score=1 
    USHBP1Q8N6Y03I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0007507heart development IEA--
    GO:0009725response to hormone IEA--
    GO:0015671oxygen transport ----
    GO:0031444slow-twitch skeletal muscle fiber contraction IEA--

    Find genes that share ontologies with MB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MB (MYG)

    2 HMDB Compounds for MB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    OxygenOxygen (see all 5)7782-44-7--

    Selected DrugBank Compounds for MB (see all 14)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-Methylimidazole-- 616-47-7target--17139284 17016423 10592235
    4-Methylimidazole-- --target--17139284 17016423 10592235
    6,7-Dicarboxyl-1,2,3,4,5,8-Hexamethylhemin-- --target--17139284 17016423 10592235
    Beta-D-Glucose-- 50-99-7target--17139284 17016423 10592235
    Biliverdine Ix Alpha-- 114-25-0target--17139284 17016423 10592235
    Ethyl Isocyanide-- --target--17139284 17016423 10592235
    Heme-- --target--17139284 17016423 10592235
    Methyl Isocyanide-- --target--17139284 17016423 10592235
    Methylethylamine-- 624-78-2target--17139284 17016423 10592235
    N-Butyl Isocyanide-- 2769-64-4target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for MB gene (see all 124)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    creatinine 83.9 903 12394946 (7), 1489857 (6), 17241501 (6), 11156346 (6) (see all 99)
    de-oxy 81.8 33 2298735 (3), 8810310 (2), 8397193 (1), 15003999 (1) (see all 24)
    fe2+ 71.9 37 7737989 (3), 9163514 (2), 18599123 (2), 2355004 (1) (see all 31)
    histidine 71.2 82 8230194 (2), 11012669 (2), 16853158 (2), 1660880 (2) (see all 59)
    oxygen 66.1 349 9889930 (5), 9269424 (4), 2298735 (3), 1413124 (3) (see all 99)
    imidazole 66.1 30 9730817 (5), 9163514 (2), 10684626 (2), 8397193 (1) (see all 20)
    haem 65 30 16305243 (2), 7935843 (2), 7752822 (1), 10724176 (1) (see all 21)
    h2o2 62.6 122 1616493 (3), 9915818 (3), 12952438 (3), 16887098 (3) (see all 80)
    porphyrin 61.2 18 2040285 (2), 8784184 (1), 9548931 (1), 9163514 (1) (see all 14)
    iron(iv) 60.6 3 9269582 (1), 1616493 (1)



    Find genes that share compounds with MB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MB gene (3 alternative transcripts): 
    NM_005368.2  NM_203377.1  NM_203378.1  

    Unigene Cluster for MB:

    Myoglobin
    Hs.517586  [show with all ESTs]
    Unigene Representative Sequence: BC014547
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000401702 ENST00000397326(uc003anz.3) ENST00000406324 ENST00000443033
    ENST00000442617 ENST00000451685 ENST00000447607 ENST00000419229 ENST00000472240(uc010gwt.2)
    ENST00000359787(uc003aob.3) ENST00000397328(uc003aoa.3)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidMB 3' UTR sequence
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MB
      QuantiTect SYBR Green Assays in human, mouse, rat MB
      QuantiFast Probe-based Assays in human, mouse, rat MB

    Additional mRNA sequence: 

    AK300657.1 AK314057.1 BC014547.1 BC018001.1 CR456516.1 CR541949.1 

    Selected DOTS entries (see all 25):

    DT.100787743  DT.101967072  DT.100787737  DT.102832861  DT.120671123  DT.97844597  DT.75146891  DT.102832858 
    DT.102832865  DT.102832859  DT.120671110  DT.101985524  DT.120671125  DT.100657908  DT.100787739  DT.102832860 
    DT.102832864  DT.120671104  DT.120671107  DT.120671114  DT.120671136  DT.120671140  DT.92428890  DT.120671092 

    Selected AceView cDNA sequences (see all 801):

    F25701 BU735683 F24494 BE645980 AJ346448 C05324 AA192159 F20917 
    F29993 AJ571958 AJ571809 AJ573209 N95822 AI183901 F29632 F27882 
    AI337526 BM697488 F33681 C05534 F24852 AA346263 AI184297 AJ710986 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MB (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g
    SP1:              -     -     -     -     -           -     -                                                   
    SP2:              -           -     -     -     -     -     -                                                   
    SP3:                    -     -     -     -           -     -                                                   
    SP4:                                      -           -     -                                                   
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for MB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTGGATCT
    MB Expression
    About this image


    MB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Skeletal Muscle (Muscoskeletal System)
             Myogenic cells
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Heart (Cardiovascular System)
     
     Thyroid (Endocrine System)
    MB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517586
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MB: 
              Oxidative Stress in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat MB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MB gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mb1 , 5 myoglobin1, 5 83.77(n)1
    83.77(a)1
      15 (36.36 cM)5
    171891  NM_013593.31  NP_038621.21 
     770154875 
    chicken
    (Gallus gallus)
    Aves MB1 myoglobin 74.24(n)
    76.62(a)
      418056  NM_001167752.2  NP_001161224.1 
    lizard
    (Anolis carolinensis)
    Reptilia MB6
    myoglobin
    71(a)
    1 ↔ 1
    5(21737716-21742466)
    zebrafish
    (Danio rerio)
    Actinopterygii mb1 myoglobin 54.55(n)
    44.06(a)
      393558  NM_200586.1  NP_956880.1 


    ENSEMBL Gene Tree for MB (if available)
    TreeFam Gene Tree for MB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MB gene
    CYGB2  
    5 SIMAP similar genes for MB using alignment to 10 protein entries:     MYG_HUMAN (see all proteins):
    HBZ    HBE1    CYGB    HBG1    HBG2

    Find genes that share paralogs with MB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MB (see all 444)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs351714581,2
    C--18967425(+) CTCTGC/-CTCCT 3 -- int13Minor allele frequency- -:0.00NA CSA 10
    rs454644001,2
    C,F--19923479(-) GGAGAG/CAGCAA 3 -- ds50017Minor allele frequency- C:0.07NS WA 292
    rs1868373201,2
    --19923493(+) GCTGGA/GGTCCC 3 -- ds50010--------
    rs455710341,2
    C,F--19923516(-) AAACTA/GTGGCC 3 -- ds50016Minor allele frequency- G:0.04NS WA 284
    rs37885121,2
    C,F,A,H--19923563(+) TCCCAC/TGTTAC 3 -- ds500121Minor allele frequency- T:0.40NS EA WA NA CSA 938
    rs1501571361,2
    --19923814(+) CTGCCG/TTTCCT 3 -- ds50010--------
    rs1138566651,2
    C--19923953(+) AGAAAC/TTGAGA 3 -- ds50010--------
    rs454477931,2
    F--19923975(-) TTTAAT/-AAAAC 3 -- ut315Minor allele frequency- -:0.06NS 168
    rs789707651,2
    C--19923976(+) TTTTAA/TTAAAA 3 -- ut310--------
    rs1398974701,2
    C--19923978(+) TTATT-/AAAACC 3 -- ut310--------

    HapMap Linkage Disequilibrium report for MB (36002811 - 36033998 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510806CNV Loss20534489
    nsv834184CNV Loss17160897

    Human Gene Mutation Database (HGMD): MB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MB
    DNA2.0 Custom Variant and Variant Library Synthesis for MB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 160000    OMIM disorders: --

    18 diseases for MB:    
    About MalaCards
    anuria    malignant triton tumor    compartment syndrome    uterine sarcoma
    acute kidney failure    medullomyoblastoma    acute mountain sickness    creatine phosphokinase, elevated serum
    pleomorphic rhabdomyosarcoma    adenosarcoma    acute myocardial infarction    malignant fibroxanthoma
    carnitine palmitoyltransferase ii deficiency    neuroleptic malignant syndrome    intermediate coronary syndrome    intestinal obstruction
    malaria    myocardial infarction

    17 diseases from the University of Copenhagen DISEASES database for MB:
    Myocardial infarction     Rhabdomyosarcoma     Kidney failure     Myopathy
    Intermediate coronary syndrome     Malignant hyperthermia     Vascular disease     Coronary heart disease
    Alveolar soft part sarcoma     Medullomyoblastoma     Neuropathy     Malignant triton tumor
    Sarcoma     Malignant fibroxanthoma     Leiomyosarcoma     Carcinosarcoma
    Granular cell tumor

    Find genes that share disorders with MB           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MB gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rhabdomyolysis 85.7 81 12394946 (4), 15280520 (3), 19797717 (2), 16267412 (2) (see all 66)
    acute myocardial infarction 76 174 15226704 (6), 1489857 (4), 9127740 (3), 11571240 (3) (see all 99)
    rhabdomyolysis exertional acute 70.1 2 17654064 (1), 7625324 (1)
    renal failure acute 70 47 19797717 (2), 12394946 (2), 7785966 (2), 11417950 (1) (see all 39)
    rhabdomyosarcoma 68.3 9 2119961 (1), 8065989 (1), 2166629 (1), 9990261 (1) (see all 9)
    rhabdomyosarcoma embryonal 65.9 1 16987772 (1)
    myocardial infarction 63.3 103 8486034 (5), 12499000 (3), 10073855 (3), 9456094 (3) (see all 77)
    crush syndrome 63.3 7 18283895 (2), 7486197 (2), 2333628 (1), 1787687 (1) (see all 5)
    rhabdomyoma 52.9 1 16133368 (1)
    myopathy 49.9 9 8230014 (1), 14506721 (1), 2375488 (1), 8787705 (1) (see all 9)

    Genetic Association Database (GAD): MB
    Human Genome Epidemiology (HuGE) Navigator: MB (657 documents)

    Export disorders for MB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MB gene, integrated from 10 sources (see all 1658):
    (articles sorted by number of sources associating them with MB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I.... Wright H. (Nature 1999)
    2. Cloning of the human myoglobin gene. (PubMed id 2989088)1, 2, 3 Akaboshi E. (Gene 1985)
    3. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Allele frequencies of single nucleotide polymorphisms in the second exon of the myoglobin gene among the Japanese. (PubMed id 12030657)1, 4 Takata T....Ishizu H. (Hum. Biol. 2002)
    6. The human myocardial two-dimensional gel protein database: update 1994. (PubMed id 7895732)1, 2 Corbett J.M.... Dunn M.J. (Electrophoresis 1994)
    7. X-ray crystal structure of a recombinant human myoglobin mutant at 2.8-A resolution. (PubMed id 2342104)1, 2 Hubbard S.R.... Boxer S.G. (J. Mol. Biol. 1990)
    8. Organization of the human myoglobin gene. (PubMed id 6571704)1, 2 Weller P.... Blanchetot A. (EMBO J. 1984)
    9. The myoglobin of primates. II. Pan troglodytes (chimpanzee). (PubMed id 4627044)1, 2 Romero-Herrera A.E. and Lehmann H. (Biochim. Biophys. Acta 1972)
    10. Primary structure of human myoglobin. (PubMed id 5285572)1, 2 Romero-Herrera A.E. and Lehmann H. (Nature New Biol. 1971)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4151 HGNC: 6915 AceView: MB Ensembl:ENSG00000198125 euGenes: HUgn4151
    ECgene: MB H-InvDB: MB

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MB Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MB gene:
    Search GeneIP for patents involving MB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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