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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MB Gene

protein-coding GIFtS: 61
GCID: GC22M036002

myoglobin

Explore 120 diseases affiliated with
MB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Myoglobin¹
PVALB¹ ²

External Ids:	HGNC: 6915¹	Entrez Gene: 4151²	Ensembl: ENSG00000198125⁷	OMIM: 160000⁵	UniProtKB: P02144³

Export aliases for MB gene to outside databases

Previous GC identifers: GC22M032646 GC22M034274 GC22M034327 GC22M018967

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MB:

This gene encodes a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The encoded

protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of

oxygen. At least three alternatively spliced transcript variants encoding the same protein have been reported.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MYG_HUMAN, P02144

Function: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles

Gene Wiki entry for MB (Myoglobin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MB gene promoter:
AP-1 MyoD
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MB promoter sequence

Search SABiosciences Chromatin IP Primers for MB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q12.3 HGNC cytogenetic band: 22q13.1

MB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MB gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M036002: view genomic region (about GC identifiers)

Start:	36,002,811 bp from pter	End:	36,033,998 bp from pter
Size:	31,188 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MYG_HUMAN, P02144 (See protein sequence)

Recommended Name: Myoglobin

Size: 154 amino acids; 17184 Da

1 PDB 3D structure from and Proteopedia for MB:

3RGK (3D)

Secondary accessions: Q52H51 Q5THY7

Explore the universe of human proteins at neXtProt for MB: NX_P02144

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P02144

MB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_005359.1 NP_976311.1 NP_976312.1

ENSEMBL proteins:

ENSP00000386060 ENSP00000380489 ENSP00000384239 ENSP00000403351 ENSP00000413309

ENSP00000397944 ENSP00000389263 ENSP00000414243 ENSP00000352835 ENSP00000380491

Human Recombinant Protein Products for MB:

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	GenScript Custom Purified and Recombinant Proteins Services for MB
	Novus Biologicals MB Proteins Novus Biologicals MB Lysates
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	ProSpec Recombinant Protein for MB
	Uscn Proteins for MB

MB Antibody Products:

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	Uscn Antibodies for MB
	ThermoFisher Antibodies for MB

Assay Products for MB:

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	GenScript Custom Assay Services for MB
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MB

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MB for domains About GeneDecksing

4 InterPro domains/families:

IPR012292 Globin_dom

IPR009050 Globin-like

IPR002335 Myoglobin

IPR000971 Globin

Graphical View of Domain Structure for InterPro Entry P02144

ProtoNet protein and cluster: P02144

1 Blocks protein family: IPB002335 Myoglobin signature

UniProtKB/Swiss-Prot: MYG_HUMAN, P02144

Similarity: Belongs to the globin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MYG_HUMAN, P02144

Function: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles

Genatlas biochemistry entry for MB:

myoglobin,17.5kDa,muscle oxygen-carrying hemoprotein,non covalently

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005344	oxygen transporter activity	IEA	--
GO:0005506	iron ion binding	IEA	--
GO:0019825	oxygen binding	IEA	--
GO:0020037	heme binding	IEA	--

MB for ontologies About GeneDecksing

Phenotypes:
9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mb):

cardiovascular system	cellular	embryogenesis	growth/size	hematopoietic system
homeostasis/metabolism	mortality/aging	muscle	respiratory system

MB for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for MB: Mb^tm1Jsc Mb^tm1Wlm

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MB

miRNA Products:		OriGene 3'-UTR Clone (see all 3): MB Browse MicroRNA Expression Plasmids
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		SwitchGear 3'UTR luciferase reporter plasmid: MB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MB (see all 7) OriGene shRNA RFP: MB OriGene siRNA: MB
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MB
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MB (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MB (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MB (NM_016519)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MB
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		Sirion Biotech Customized stable knockdown cell line services for MB Sirion Biotech Customized inducible knockdown cell line services for MB Sirion Biotech Customized stable overexpressing cell line services for MB Sirion Biotech Customized inducible overexpressing cell line services for MB

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MB

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MB

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

5/6 Interacting proteins for MB (P02144³ ENSP00000352835⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KRT15	P19012³	I2D: score=1
MTUS2	Q5JR59³	I2D: score=1
PSMC6	P62333³	I2D: score=1
PSMD4	P55036³	I2D: score=1
USHBP1	Q8N6Y0³	I2D: score=1

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IEA	--
GO:0007507	heart development	IEA	--
GO:0009725	response to hormone stimulus	IEA	--
GO:0015671	oxygen transport	--	--
GO:0031444	slow-twitch skeletal muscle fiber contraction	IEA	--

MB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MB for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MB

2 HMDB Compounds for MB About this table

Compound	Synonyms	CAS #	PubMed Ids
Heme	(protoporphyrinato)iron (see all 19)	14875-96-8	--
Oxygen	Oxygen (see all 5)	7782-44-7	--

10/14 DrugBank Compounds for MB (see all 14) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
1-Methylimidazole	--	616-47-7	target	--	17139284 17016423 10592235
4-Methylimidazole	--	--	target	--	17139284 17016423 10592235
6,7-Dicarboxyl-1,2,3,4,5,8-Hexamethylhemin	--	--	target	--	17139284 17016423 10592235
Beta-D-Glucose	--	50-99-7	target	--	17139284 17016423 10592235
Biliverdine Ix Alpha	--	114-25-0	target	--	17139284 17016423 10592235
Ethyl Isocyanide	--	--	target	--	17139284 17016423 10592235
Heme	--	--	target	--	17139284 17016423 10592235
Methyl Isocyanide	--	--	target	--	17139284 17016423 10592235
Methylethylamine	--	624-78-2	target	--	17139284 17016423 10592235
N-Butyl Isocyanide	--	2769-64-4	target	--	17139284 17016423 10592235

10/124 Novoseek chemical compound relationships for MB gene (see all 124) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
creatinine	83.9	903	12394946 (7), 1489857 (6), 17241501 (6), 11156346 (6) (see all 99)
de-oxy	81.8	33	2298735 (3), 8810310 (2), 8397193 (1), 15003999 (1) (see all 24)
fe2+	71.9	37	7737989 (3), 9163514 (2), 18599123 (2), 2355004 (1) (see all 31)
histidine	71.2	82	8230194 (2), 11012669 (2), 16853158 (2), 1660880 (2) (see all 59)
oxygen	66.1	349	9889930 (5), 9269424 (4), 2298735 (3), 1413124 (3) (see all 99)
imidazole	66.1	30	9730817 (5), 9163514 (2), 10684626 (2), 8397193 (1) (see all 20)
haem	65	30	16305243 (2), 7935843 (2), 7752822 (1), 10724176 (1) (see all 21)
h2o2	62.6	122	1616493 (3), 9915818 (3), 12952438 (3), 16887098 (3) (see all 80)
porphyrin	61.2	18	2040285 (2), 8784184 (1), 9548931 (1), 9163514 (1) (see all 14)
iron(iv)	60.6	3	9269582 (1), 1616493 (1)

Search CenterWatch for drugs/clinical trials and news about MB / MYG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MB gene (3 alternative transcripts):

NM_005368.2 NM_203377.1 NM_203378.1

Unigene Cluster for MB:

Myoglobin

Hs.517586 [show with all ESTs]

Unigene Representative Sequence: BF670653

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000401702 ENST00000397326(uc003anz.3) ENST00000406324 ENST00000443033

ENST00000442617 ENST00000451685 ENST00000447607 ENST00000419229 ENST00000472240(uc010gwt.2)

ENST00000359787(uc003aob.3) ENST00000397328(uc003aoa.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): MB Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MB
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MB
		SwitchGear 3'UTR luciferase reporter plasmid: MB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MB (see all 7) OriGene shRNA RFP: MB OriGene siRNA: MB
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MB (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MB (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MB (NM_016519)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MB

Additional cDNA sequence:

AK300657.1 AK314057.1 BC014547.1 BC018001.1 CR456516.1 CR541949.1

24/26 DOTS entries (see all 26):

DT.100787743 DT.101967072 DT.120671123 DT.102832861 DT.100787737 DT.97844597 DT.75146891 DT.102832865

DT.102832858 DT.102832859 DT.120671110 DT.120671125 DT.101985524 DT.120671132 DT.100657908 DT.100787739

DT.102832860 DT.102832864 DT.120671092 DT.120671104 DT.120671107 DT.120671114 DT.120671134 DT.120671136

24/801 AceView cDNA sequences (see all 801):

F35461 F30747 F30799 NM_005368 AJ573778 F28651 F26446 C05439

F25701 AJ709595 AA310534 AJ573637 AJ711841 AI277893 BU584336 AJ571809

F19486 C05538 F24727 F27789 F27489 F31070 F29993 C05236

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MB (see all 7) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7	^	8a	·	8b	·	8c	·	8d	·	8e	·	8f	·	8g
SP1:					-		-		-		-		-				-		-
SP2:					-				-		-		-		-		-		-
SP3:							-		-		-		-				-		-
SP4:													-				-		-
SP5:

ECgene alternative splicing isoforms for MB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTTGGATCT

About this image

MB expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Interscapular Brown Adipose Depot

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Primitive gut tube-like cells (A scalable, suspensi...)

See MB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MB

SOURCE GeneReport for Unigene cluster: Hs.517586

SABiosciences Expression via Pathway-Focused PCR Arrays including MB:

Oxidative Stress in human mouse rat

Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MB Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MB

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MB gene from 4/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mb^{1 , 5}	myoglobin^{1, 5}	83.77(n)¹ 83.77(a)¹		15 (36.36 cM)⁵ 17189¹ NM_001164047.1¹ NP_001157519.1¹ 77015487⁵
chicken (Gallus gallus)	Aves	MB¹	myoglobin	74.24(n) 76.62(a)		418056 NM_001167752.1 NP_001161224.1
lizard (Anolis carolinensis)	Reptilia	MB⁶	--	71(a)	1 ↔ 1	5(21737716-21742466)
zebrafish (Danio rerio)	Actinopterygii	mb¹	myoglobin	54.93(n) 43.66(a)		393558 NM_200586.1 NP_956880.1

ENSEMBL Gene Tree for MB (if available)
TreeFam Gene Tree for MB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs45464400^1,2	C,F	--	18962838(-)	`GGAGAG/CAGCAA`	3	--	ds500¹		7	NS WA	292
rs45571034^1,2	C,F	--	18962875(-)	`AAACTA/GTGGCC`	3	--	ds500¹		6	NS WA	284
rs45447793^1,2	F	--	18963334(-)	`TTTAAT/-AAAAC`	3	--	ut3¹		5	NS	168
rs45446591^1,2	C	--	18963487(-)	`AGCAAT/GTGTCT`	3	--	ut3¹		6	NS NA	310
rs45570036^1,2	C,F	--	18964262(-)	`CGGCCC/TTCCTG`	3	--	int¹		7	NS WA EA	382
rs45591134^1,2	C,F	--	18964382(-)	`ATTTCC/TCTTCT`	3	--	int¹		6	NS NA	308
rs45538131^1,2	C,F	--	18964606(-)	`AGCCGC/TGGGCC`	3	--	int¹		5	NS	154
rs45579745^1,2	C	--	18965057(-)	`TTCTTG/CAGGCC`	3	--	int¹		6	NS WA	306
rs76536744^1,2		--	18965403(+)	`CTCTCG/AGCACC`	3	--	int¹		1	WA	118
rs45518431^1,2	C,F	--	18965630(-)	`AAAACC/TATGCA`	3	--	int¹		7	NS WA	300

HapMap Linkage Disequilibrium report for MB (36002811 - 36033998 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MB: --
Human Gene Mutation Database (HGMD): MB

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MB

DNA2.0 Custom Variant and Variant Library Synthesis for MB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MB for disorders           About GeneDecksing

OMIM gene information: 160000    OMIM disorders: --

20/120 diseases for MB (see all 120):    About MalaCards

creatine phosphokinase, elevated serum creatine phosphokinase disseminated intravascular coagulation desmoplastic small round cell tumor

alveolar soft part sarcoma neuroleptic malignant syndrome acute mountain sickness cor pulmonale

microscopic polyangiitis malignant triton tumor amyotrophic lateral sclerosis plasmodium falciparum malaria

myocardial infarction compartment syndrome anuria acute myocardial infarction

duchenne muscular dystrophy adenosarcoma muscular dystrophy back pain

14 diseases from the University of Copenhagen DISEASES database for MB:

Myocardial infarction Rhabdomyosarcoma Kidney failure Myopathy

Intermediate coronary syndrome Malignant hyperthermia Vascular disease Coronary heart disease

Neuropathy Alveolar soft part sarcoma Sarcoma Malignant triton tumor

Malignant fibroxanthoma Leiomyosarcoma

10/96 Novoseek disease relationships for MB gene (see all 96) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rhabdomyolysis	85.7	81	12394946 (4), 15280520 (3), 19797717 (2), 16267412 (2) (see all 66)
acute myocardial infarction	76	174	15226704 (6), 1489857 (4), 9127740 (3), 11571240 (3) (see all 99)
rhabdomyolysis exertional acute	70.1	2	17654064 (1), 7625324 (1)
renal failure acute	70	47	19797717 (2), 12394946 (2), 7785966 (2), 11417950 (1) (see all 39)
rhabdomyosarcoma	68.3	9	2119961 (1), 8065989 (1), 2166629 (1), 9990261 (1) (see all 9)
rhabdomyosarcoma embryonal	65.9	1	16987772 (1)
myocardial infarction	63.3	103	8486034 (5), 12499000 (3), 10073855 (3), 9456094 (3) (see all 77)
crush syndrome	63.3	7	18283895 (2), 7486197 (2), 2333628 (1), 1787687 (1) (see all 5)
rhabdomyoma	52.9	1	16133368 (1)
myopathy	49.9	9	8230014 (1), 14506721 (1), 2375488 (1), 8787705 (1) (see all 9)

Genetic Association Database (GAD): MB
Human Genome Epidemiology (HuGE) Navigator: MB (657 documents)

Export disorders for MB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MB gene, integrated from 9 sources (see all 1654):
(articles sorted by number of sources associating them with MB)

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The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2, 3} Dunham I....O'Brien K.P. (1999)
Cloning of the human myoglobin gene. (PubMed id 2989088)^{1, 2, 3} Akaboshi E. (1985)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Allele frequencies of single nucleotide polymorphisms in the second exon of the myoglobin gene among the Japanese. (PubMed id 12030657)^{1, 4} Takata T....Ishizu H. (2002)
The human myocardial two-dimensional gel protein database: update 1994. (PubMed id 7895732)^{1, 2} Corbett J.M.... Dunn M.J. (1994)
X-ray crystal structure of a recombinant human myoglobin mutant at 2.8-A resolution. (PubMed id 2342104)^{1, 2} Hubbard S.R.... Boxer S.G. (1990)
Organization of the human myoglobin gene. (PubMed id 6571704)^{1, 2} Weller P.... Blanchetot A. (1984)
The myoglobin of primates. II. Pan troglodytes (chimpanzee). (PubMed id 4627044)^{1, 2} Romero-Herrera A.E. and Lehmann H. (1972)
Primary structure of human myoglobin. (PubMed id 5285572)^{1, 2} Romero-Herrera A.E. and Lehmann H. (1971)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4151	HGNC: 6915	AceView: MB	Ensembl:ENSG00000198125	euGenes: HUgn4151
ECgene: MB	H-InvDB: MB

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MB	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/mb/

Intellectual Property for MB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MB gene:
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GeneCards and IP:
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MB Gene

myoglobin

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