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Aliases for MAZ Gene

Aliases for MAZ Gene

  • MYC Associated Zinc Finger Protein 2 3 5
  • Purine-Binding Transcription Factor 2 3 4
  • Transcription Factor Zif87 3 4
  • Zinc Finger Protein 801 3 4
  • ZNF801 3 4
  • Pur-1 3 4
  • SAF-1 3 4
  • MAZI 3 4
  • ZF87 3 4
  • MYC-Associated Zinc Finger Protein (Purine-Binding Transcription Factor) 2
  • Serum Amyloid A Activating Factor 1 3
  • Serum Amyloid A Activating Factor 2 3
  • Zinc-Finger Protein, 87 Kilodaltons 3
  • Serum Amyloid A-Activating Factor-1 4
  • Myc-Associated Zinc Finger Protein 3
  • SAF-2 3
  • SAF-3 3
  • Zif87 3
  • PUR1 3

External Ids for MAZ Gene

Previous GeneCards Identifiers for MAZ Gene

  • GC16M029338
  • GC16P030140
  • GC16P029816
  • GC16P029855
  • GC16P029725
  • GC16P029817
  • GC16P027479

Summaries for MAZ Gene

GeneCards Summary for MAZ Gene

MAZ (MYC Associated Zinc Finger Protein) is a Protein Coding gene. Among its related pathways are SIDS Susceptibility Pathways. GO annotations related to this gene include nucleic acid binding and chromatin binding. An important paralog of this gene is VEZF1.

UniProtKB/Swiss-Prot for MAZ Gene

  • May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins.

Gene Wiki entry for MAZ Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAZ Gene

Genomics for MAZ Gene

Regulatory Elements for MAZ Gene

Enhancers for MAZ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F029942 1.7 FANTOM5 Ensembl ENCODE 10.1 +137.9 137900 3.7 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZNF207 FOS ENSG00000260853 MIR4517 SMG1P2 INO80E ENSG00000260367 ZNF785 CD2BP2 CDIPT NPIPB13 ENSG00000247735
GH16F030538 1.3 Ensembl ENCODE 10 +735.3 735319 5.3 PKNOX1 ATF1 ARNT MLX ARID4B DMAP1 ZNF48 ZNF121 ZNF302 FOS ZNF764 ZNF785 CD2BP2 ENSG00000235560 SMG1P2 ENSG00000260267 ENSG00000260304 ENSG00000239791 ZNF688 BCL7C
GH16F029862 1.2 ENCODE 10.2 +57.0 57040 2.1 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 CDIPT-AS1 ZNF785 CD2BP2 ENSG00000261766 ENSG00000260114 DOC2A TMEM219 MAZ ENSG00000278713
GH16F029961 1.2 ENCODE 10.1 +156.3 156305 2.5 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 INO80E ZNF764 ENSG00000260853 ENSG00000260367 ZNF747 ZNF785 SMG1P2 NPIPB13 BCL7C PRR14
GH16F029992 1.2 ENCODE 10.1 +188.8 188841 4.8 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 MIR762HG CA5AP1 SMG1P2 ZNF785 C16orf92 FAM57B TAOK2 CTF1 ZNF747 ENSG00000247735
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAZ on UCSC Golden Path with GeneCards custom track

Promoters for MAZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001800849 617 3801 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143

Genomic Location for MAZ Gene

Chromosome:
16
Start:
29,806,083 bp from pter
End:
29,811,183 bp from pter
Size:
5,101 bases
Orientation:
Plus strand

Genomic View for MAZ Gene

Genes around MAZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAZ Gene

Proteins for MAZ Gene

  • Protein details for MAZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56270-MAZ_HUMAN
    Recommended name:
    Myc-associated zinc finger protein
    Protein Accession:
    P56270
    Secondary Accessions:
    • A8QJL9
    • C6G496
    • G5E927
    • H3BQD6
    • Q15703
    • Q8NFN7
    • Q99443

    Protein attributes for MAZ Gene

    Size:
    477 amino acids
    Molecular mass:
    48608 Da
    Quaternary structure:
    • Interacts with BPTF.
    SequenceCaution:
    • Sequence=AAB04121.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA12728.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAZ Gene

Post-translational modifications for MAZ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAZ Gene

Domains & Families for MAZ Gene

Gene Families for MAZ Gene

Protein Domains for MAZ Gene

Suggested Antigen Peptide Sequences for MAZ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56270

UniProtKB/Swiss-Prot:

MAZ_HUMAN :
  • Contains 6 C2H2-type zinc fingers.
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with MAZ: view

Function for MAZ Gene

Molecular function for MAZ Gene

GENATLAS Biochemistry:
MYC-associated zinc finger gene,60kDa,housekeeping gene,involved in transcription termination and initiation,widely expressed except in kidney
UniProtKB/Swiss-Prot Function:
May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins.

Gene Ontology (GO) - Molecular Function for MAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IDA 1502157
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 11527412
genes like me logo Genes that share ontologies with MAZ: view
genes like me logo Genes that share phenotypes with MAZ: view

Animal Model Products

miRNA for MAZ Gene

miRTarBase miRNAs that target MAZ
Targeted motifs for MAZ Gene
HOMER Transcription Factor Regulatory Elements motif MAZ
  • Consensus sequence: GGGGGGGG Submotif: canonical Cell Type: HepG2 GEO ID: GSE31477

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for MAZ Gene

Localization for MAZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAZ Gene

Nucleus. Note=In brains of Alzheimer disease patients, present in a plaque-like structures.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAZ gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MAZ: view

Pathways & Interactions for MAZ Gene

SuperPathway Contained pathways
1 SIDS Susceptibility Pathways
genes like me logo Genes that share pathways with MAZ: view

Pathways by source for MAZ Gene

1 BioSystems pathway for MAZ Gene

SIGNOR curated interactions for MAZ Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter IDA 1502157
GO:0006369 termination of RNA polymerase II transcription IDA 1502157
genes like me logo Genes that share ontologies with MAZ: view

Drugs & Compounds for MAZ Gene

(6) Drugs for MAZ Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MAZ Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAZ: view

Transcripts for MAZ Gene

Unigene Clusters for MAZ Gene

MYC-associated zinc finger protein (purine-binding transcription factor):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAZ Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - -
SP8: - -
SP9: - - -
SP10: -

Relevant External Links for MAZ Gene

GeneLoc Exon Structure for
MAZ
ECgene alternative splicing isoforms for
MAZ

Expression for MAZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAZ Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.1), NK cells (10.2), Fetal Brain (10.2), and Platelet (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAZ Gene



Protein tissue co-expression partners for MAZ Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAZ Gene:

MAZ

SOURCE GeneReport for Unigene cluster for MAZ Gene:

Hs.23650

mRNA Expression by UniProt/SwissProt for MAZ Gene:

P56270-MAZ_HUMAN
Tissue specificity: Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level).
genes like me logo Genes that share expression patterns with MAZ: view

No data available for mRNA differential expression in normal tissues for MAZ Gene

Orthologs for MAZ Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAZ 34 35
  • 99.75 (n)
cow
(Bos Taurus)
Mammalia MAZ 34
  • 97.79 (n)
dog
(Canis familiaris)
Mammalia MAZ 34 35
  • 94.83 (n)
mouse
(Mus musculus)
Mammalia Maz 34 16 35
  • 93.21 (n)
rat
(Rattus norvegicus)
Mammalia Maz 34
  • 92.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 77 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia MAZ 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia maz 34
  • 72.63 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398491 34
zebrafish
(Danio rerio)
Actinopterygii LOC100148700 34
  • 64.07 (n)
maza 35
  • 37 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2801 34
Species where no ortholog for MAZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAZ Gene

ENSEMBL:
Gene Tree for MAZ (if available)
TreeFam:
Gene Tree for MAZ (if available)

Paralogs for MAZ Gene

Paralogs for MAZ Gene

genes like me logo Genes that share paralogs with MAZ: view

Variants for MAZ Gene

Sequence variations from dbSNP and Humsavar for MAZ Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs755847991 Uncertain significance 29,804,887(+) GGAGC(A/T)ACTGG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs201550112 Benign 29,805,250(+) CTCCC(-/TCCT)GTGTT intron-variant, upstream-variant-2KB
rs1043766 -- 29,808,663(+) AGATG(A/C/T)TGAGC nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon, missense
rs1043917 -- 29,810,877(+) AAGAG(A/C)CAGGA nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1043920 -- 29,810,881(+) GCCAG(A/G)AGGGC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MAZ Gene

Variant ID Type Subtype PubMed ID
dgv34n68 CNV loss 17160897
esv22680 CNV loss 19812545
nsv1126424 CNV deletion 24896259
nsv827610 CNV gain 20364138
nsv827611 CNV gain 20364138
nsv833186 CNV loss 17160897
nsv953800 CNV deletion 24416366

Variation tolerance for MAZ Gene

Residual Variation Intolerance Score: 6.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAZ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAZ Gene

Disorders for MAZ Gene

Relevant External Links for MAZ

Genetic Association Database (GAD)
MAZ
Human Genome Epidemiology (HuGE) Navigator
MAZ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAZ

No disorders were found for MAZ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAZ Gene

Publications for MAZ Gene

  1. MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination. (PMID: 1502157) Bossone S.A. … Marcu K.B. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 22 64
  2. Isolation of a novel cDNA encoding a zinc-finger protein that binds to two sites within the c-myc promoter. (PMID: 1567856) Pyrc J.J. … Hall D.J. (Biochemistry 1992) 2 3 4 22 64
  3. SAF-3, a novel splice variant of the SAF-1/MAZ/Pur-1 family, is expressed during inflammation. (PMID: 19583771) Ray A. … Ray B.K. (FEBS J. 2009) 3 4 22 64
  4. SAF-2, a splice variant of SAF-1, acts as a negative regulator of transcription. (PMID: 12270922) Ray B.K. … Ray A. (J. Biol. Chem. 2002) 3 4 22 64
  5. Genomic organization and expression of a human gene for Myc- associated zinc finger protein (MAZ). (PMID: 9685418) Song J. … Yokoyama K.K. (J. Biol. Chem. 1998) 3 4 22 64

Products for MAZ Gene

Sources for MAZ Gene

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