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Aliases for MAZ Gene

Aliases for MAZ Gene

  • MYC Associated Zinc Finger Protein 2 3
  • MYC-Associated Zinc Finger Protein (Purine-Binding Transcription Factor) 2 3 5
  • Purine-Binding Transcription Factor 2 3 4
  • Serum Amyloid A-Activating Factor-1 3 4
  • Transcription Factor Zif87 3 4
  • Zinc Finger Protein 801 3 4
  • ZNF801 3 4
  • Pur-1 3 4
  • SAF-1 3 4
  • MAZI 3 4
  • ZF87 3 4
  • Serum Amyloid A Activating Factor 1 3
  • Serum Amyloid A Activating Factor 2 3
  • Zinc-Finger Protein, 87 Kilodaltons 3
  • SAF-2 3
  • SAF-3 3
  • Zif87 3
  • PUR1 3

External Ids for MAZ Gene

Previous GeneCards Identifiers for MAZ Gene

  • GC16M029338
  • GC16P030140
  • GC16P029816
  • GC16P029855
  • GC16P029725
  • GC16P029817
  • GC16P027479

Summaries for MAZ Gene

GeneCards Summary for MAZ Gene

MAZ (MYC Associated Zinc Finger Protein) is a Protein Coding gene. Diseases associated with MAZ include Mental Retardation, Autosomal Dominant 31. Among its related pathways are SIDS Susceptibility Pathways. GO annotations related to this gene include nucleic acid binding and chromatin binding. An important paralog of this gene is PATZ1.

UniProtKB/Swiss-Prot for MAZ Gene

  • May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins.

Gene Wiki entry for MAZ Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAZ Gene

Genomics for MAZ Gene

Regulatory Elements for MAZ Gene

Enhancers for MAZ Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAZ on UCSC Golden Path with GeneCards custom track

Promoters for MAZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAZ on UCSC Golden Path with GeneCards custom track

Genomic Location for MAZ Gene

Chromosome:
16
Start:
29,806,083 bp from pter
End:
29,811,183 bp from pter
Size:
5,101 bases
Orientation:
Plus strand

Genomic View for MAZ Gene

Genes around MAZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAZ Gene

Proteins for MAZ Gene

  • Protein details for MAZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56270-MAZ_HUMAN
    Recommended name:
    Myc-associated zinc finger protein
    Protein Accession:
    P56270
    Secondary Accessions:
    • A8QJL9
    • C6G496
    • G5E927
    • H3BQD6
    • Q15703
    • Q8NFN7
    • Q99443

    Protein attributes for MAZ Gene

    Size:
    477 amino acids
    Molecular mass:
    48608 Da
    Quaternary structure:
    • Interacts with BPTF.
    SequenceCaution:
    • Sequence=AAB04121.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA12728.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAZ Gene

Proteomics data for MAZ Gene at MOPED

Post-translational modifications for MAZ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAZ Gene

Domains & Families for MAZ Gene

Gene Families for MAZ Gene

Protein Domains for MAZ Gene

Suggested Antigen Peptide Sequences for MAZ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56270

UniProtKB/Swiss-Prot:

MAZ_HUMAN :
  • Contains 6 C2H2-type zinc fingers.
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with MAZ: view

Function for MAZ Gene

Molecular function for MAZ Gene

GENATLAS Biochemistry:
MYC-associated zinc finger gene,60kDa,housekeeping gene,involved in transcription termination and initiation,widely expressed except in kidney
UniProtKB/Swiss-Prot Function:
May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins.

Gene Ontology (GO) - Molecular Function for MAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IDA 1502157
GO:0003676 nucleic acid binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MAZ: view
genes like me logo Genes that share phenotypes with MAZ: view

Animal Model Products

miRNA for MAZ Gene

miRTarBase miRNAs that target MAZ
Targeted motifs for MAZ Gene
HOMER Transcription Factor Regulatory Elements motif MAZ
  • Consensus sequence: GGGGGGGG Submotif: canonical Cell Type: HepG2 GEO ID: GSE31477

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for MAZ Gene

Localization for MAZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAZ Gene

Nucleus. Note=In brains of Alzheimer disease patients, present in a plaque-like structures.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAZ Gene COMPARTMENTS Subcellular localization image for MAZ gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for MAZ Gene

Pathways & Interactions for MAZ Gene

SuperPathways for MAZ Gene

genes like me logo Genes that share pathways with MAZ: view

Pathways by source for MAZ Gene

1 BioSystems pathway for MAZ Gene

SIGNOR curated interactions for MAZ Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter IDA 1502157
genes like me logo Genes that share ontologies with MAZ: view

Drugs & Compounds for MAZ Gene

(6) Drugs for MAZ Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MAZ Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAZ: view

Transcripts for MAZ Gene

Unigene Clusters for MAZ Gene

MYC-associated zinc finger protein (purine-binding transcription factor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAZ Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - -
SP8: - -
SP9: - - -
SP10: -

Relevant External Links for MAZ Gene

GeneLoc Exon Structure for
MAZ
ECgene alternative splicing isoforms for
MAZ

Expression for MAZ Gene

mRNA expression in normal human tissues for MAZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAZ Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.1), NK cells (10.2), Fetal Brain (10.2), and Platelet (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAZ Gene



SOURCE GeneReport for Unigene cluster for MAZ Gene Hs.23650

mRNA Expression by UniProt/SwissProt for MAZ Gene

P56270-MAZ_HUMAN
Tissue specificity: Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level).
genes like me logo Genes that share expression patterns with MAZ: view

Protein tissue co-expression partners for MAZ Gene

- Elite partner

No data available for mRNA differential expression in normal tissues for MAZ Gene

Orthologs for MAZ Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAZ Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAZ 35
  • 97.79 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia MAZ 35
  • 94.83 (n)
  • 97.82 (a)
MAZ 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Maz 35
  • 93.21 (n)
  • 98.36 (a)
Maz 16
Maz 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAZ 35
  • 99.75 (n)
  • 100 (a)
MAZ 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Maz 35
  • 92.66 (n)
  • 98.36 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia MAZ 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia maz 35
  • 72.63 (n)
  • 75.17 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398491 35
zebrafish
(Danio rerio)
Actinopterygii LOC100148700 35
  • 64.07 (n)
  • 59.66 (a)
maza 36
  • 37 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2801 35
Species with no ortholog for MAZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAZ Gene

ENSEMBL:
Gene Tree for MAZ (if available)
TreeFam:
Gene Tree for MAZ (if available)

Paralogs for MAZ Gene

Paralogs for MAZ Gene

genes like me logo Genes that share paralogs with MAZ: view

Variants for MAZ Gene

Sequence variations from dbSNP and Humsavar for MAZ Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11558999 -- 29,807,665(+) ACCAC(C/T)TGAAC intron-variant, reference, synonymous-codon
rs2516820 -- 29,807,894(+) GCCTG(C/G)CCGTG intron-variant
rs2516821 -- 29,807,952(+) TCCCA(C/G)GGCGG intron-variant
rs2516822 -- 29,808,010(+) GTCGA(C/G/T)GAGGT intron-variant
rs111993640 -- 29,806,677(+) AGCCC(C/T)GGGGG intron-variant, nc-transcript-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MAZ Gene

Variant ID Type Subtype PubMed ID
dgv34n68 CNV Loss 17160897
nsv833186 CNV Loss 17160897
dgv2667n71 CNV Loss 21882294
esv22680 CNV Loss 19812545
nsv827610 CNV Gain 20364138
nsv827611 CNV Gain 20364138

Variation tolerance for MAZ Gene

Residual Variation Intolerance Score: 6.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.94% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MAZ Gene

Disorders for MAZ Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAZ Gene - From: OMIM

Disorder Aliases PubMed IDs
mental retardation, autosomal dominant 31
  • mrd31
- elite association - COSMIC cancer census association via MalaCards
Search MAZ in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAZ

Genetic Association Database (GAD)
MAZ
Human Genome Epidemiology (HuGE) Navigator
MAZ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAZ
genes like me logo Genes that share disorders with MAZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAZ Gene

Publications for MAZ Gene

  1. MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination. (PMID: 1502157) Bossone S.A. … Marcu K.B. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 23 67
  2. Isolation of a novel cDNA encoding a zinc-finger protein that binds to two sites within the c-myc promoter. (PMID: 1567856) Pyrc J.J. … Hall D.J. (Biochemistry 1992) 2 3 23
  3. Transcriptional synergy mediated by SAF-1 and AP-1: critical role of N-terminal polyalanine and two zinc finger domains of SAF-1. (PMID: 19028685) Kumar D. … Ray B.K. (J. Biol. Chem. 2009) 3 23
  4. SAF-3, a novel splice variant of the SAF-1/MAZ/Pur-1 family, is expressed during inflammation. (PMID: 19583771) Ray A. … Ray B.K. (FEBS J. 2009) 3 23
  5. MAZ drives tumor-specific expression of PPAR gamma 1 in breast cancer cells. (PMID: 17902047) Wang X. … Kilgore M.W. (Breast Cancer Res. Treat. 2008) 3 23

Products for MAZ Gene

Sources for MAZ Gene

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