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MAZ Gene

protein-coding   GIFtS: 60
GCID: GC16P029817

MYC-Associated Zinc Finger Protein (Purine-Binding Transcription...

  Search for MAZ
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MYC-Associated Zinc Finger Protein (Purine-Binding Transcription
Factor)1 2
     ZNF8012 3
ZF872 3 5     PUR12 5
Purine-Binding Transcription Factor2 3     SAF-22
Serum Amyloid A-Activating Factor-12 3     SAF-32
Transcription Factor Zif872 3     Zif872
Zinc Finger Protein 8012 3     Myc-Associated Zinc Finger Protein2
MAZI2 3     Serum Amyloid A Activating Factor 12
Pur-12 3     Serum Amyloid A Activating Factor 22
SAF-12 3     Zinc-Finger Protein, 87 Kilodaltons2

External Ids:    HGNC: 69141   Entrez Gene: 41502   Ensembl: ENSG000001034957   OMIM: 6009995   UniProtKB: P562703   

Export aliases for MAZ gene to outside databases

Previous GC identifers: GC16M029338 GC16P030140 GC16P029816 GC16P029855 GC16P029725 GC16P027479


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MAZ Gene:
MAZ (MYC-associated zinc finger protein (purine-binding transcription factor)) is a protein-coding gene. GO annotations related to this gene include RNA binding and sequence-specific DNA binding RNA polymerase II transcription factor activity. An important paralog of this gene is VEZF1.

UniProtKB/Swiss-Prot: MAZ_HUMAN, P56270
Function: May function as a transcription factor with dual roles in transcription initiation and termination.
Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds
to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates
inflammation-induced expression of serum amyloid A proteins

Gene Wiki entry for MAZ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAZ gene promoter:
         GR   PPAR-gamma1   p53   HSF2   ATF-2   c-Myb   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAZ promoter sequence
   Search Chromatin IP Primers for MAZ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

MAZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAZ gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P029817:  view genomic region     (about GC identifiers)

Start:
29,817,427 bp from pter      End:
29,823,649 bp from pter
Size:
6,223 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MAZ_HUMAN, P56270 (See protein sequence)
Recommended Name: Myc-associated zinc finger protein  
Size: 477 amino acids; 48608 Da
Subunit: Interacts with BPTF
Sequence caution: Sequence=AAB04121.1; Type=Erroneous initiation; Sequence=BAA12728.1; Type=Erroneous initiation;
Secondary accessions: A8QJL9 C6G496 G5E927 Q15703 Q8NFN7 Q99443
Alternative splicing: 3 isoforms:  P56270-1   P56270-2   P56270-3   (Very low expression in normal tissues, but high expression during inflammation. The transactivation potential of SAF-3 is much greater than that of the predominantly expressed form 1)

Explore the universe of human proteins at neXtProt for MAZ: NX_P56270

Explore proteomics data for MAZ at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MAZ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001036004.1  NP_001263204.1  NP_001263205.1  NP_002374.2  

    ENSEMBL proteins: 
     ENSP00000443956   ENSP00000313362   ENSP00000455726   ENSP00000461174   ENSP00000457310  
     ENSP00000219782   ENSP00000456179   ENSP00000460057   ENSP00000455794   ENSP00000455913  
     ENSP00000461630   ENSP00000455473   ENSP00000460877   ENSP00000458201   ENSP00000458376  

    MAZ Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals MAZ Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for MAZ

     
    Search eBioscience for Proteins for MAZ 

    MAZ Antibody Products:

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    LSBio Antibodies in human, mouse, rat for MAZ

    MAZ Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAZ
    Cloud-Clone Corp. CLIAs for MAZ
    Search eBioscience for ELISAs for MAZ 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P56270

    ProtoNet protein and cluster: P56270

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: MAZ_HUMAN, P56270
    Similarity: Contains 6 C2H2-type zinc fingers


    Find genes that share domains with MAZ           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAZ_HUMAN, P56270
    Function: May function as a transcription factor with dual roles in transcription initiation and termination.
    Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds
    to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates
    inflammation-induced expression of serum amyloid A proteins

         Genatlas biochemistry entry for MAZ:
    MYC-associated zinc finger gene,60kDa,housekeeping gene,involved in transcription termination and
    initiation,widely expressed except in kidney

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IDA1502157
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
         
    Find genes that share ontologies with MAZ           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MAZ:
     Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAZ
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAZ
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAZ

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  GGGGGGGG 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAZ:
    hsa-mir-148b-3p (MIRT019432), hsa-mir-324-5p (MIRT043202), hsa-mir-193b-3p (MIRT041430), hsa-mir-1180-3p (MIRT035938), hsa-mir-122-5p (MIRT023351), hsa-mir-30d-5p (MIRT047788), hsa-mir-615-3p (MIRT040168), hsa-mir-181a-5p (MIRT047310), hsa-mir-124-3p (MIRT023060), hsa-mir-877-3p (MIRT037070), hsa-mir-222-3p (MIRT046789), hsa-mir-326 (MIRT043629)

    Block miRNA regulation of human, mouse, rat MAZ using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAZ (see all 32):
    hsa-miR-328 hsa-miR-29a hsa-miR-449a hsa-miR-3150b-3p hsa-miR-3909 hsa-miR-615-5p hsa-miR-34c-5p hsa-miR-1237
    SwitchGear 3'UTR luciferase reporter plasmidMAZ 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MAZ

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for MAZ (see all 12)
    OriGene ORF clones in mouse, rat for MAZ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MAZ (NM_002383)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAZ

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAZ


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAZ_HUMAN, P56270: Nucleus (Probable). Note=In brains of Alzheimer disease patients, present in a plaque-like
    structures
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with MAZ           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAZ About    
    See pathways by source

    SuperPathContained pathways About
    1SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways


    1 BioSystems Pathway for MAZ
        SIDS Susceptibility Pathways


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAZ
    Interactions:

        GeneGlobe Interaction Network for MAZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for MAZ (P562701, 3 ENSP000002197824) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCCP431461, 3, ENSP000003891404EBI-1809742,EBI-1222919 I2D: score=3 STRING: ENSP00000389140
    BPTFQ128303, ENSP000003072084I2D: score=3 STRING: ENSP00000307208
    KEAP1Q141453, ENSP000001711114I2D: score=2 STRING: ENSP00000171111
    JUNP054123, ENSP000003602664I2D: score=1 STRING: ENSP00000360266
    CSNK2A1P684003, ENSP000002172444I2D: score=2 STRING: ENSP00000217244
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter ----
    GO:0006367transcription initiation from RNA polymerase II promoter IDA1502157
    GO:0006369termination of RNA polymerase II transcription IDA1502157
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--

    Find genes that share ontologies with MAZ           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAZ

    8 Novoseek inferred chemical compound relationships for MAZ gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 71.4 70 11395515 (5), 12270922 (3), 1502157 (3), 19583771 (2) (see all 33)
    alanine 33 12 10448092 (2), 11809795 (1), 8831693 (1), 19028685 (1) (see all 6)
    chloramphenicol 25.8 2 8831693 (1), 9685418 (1)
    oligonucleotide 9.37 1 7794930 (1)
    threonine 4.33 1 11809795 (1)
    retinoic acid 2.67 3 11733135 (1), 11527412 (1)
    nitric oxide 0 2 12684688 (1)
    serine 0 6 10448092 (4)



    Find genes that share compounds with MAZ           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAZ gene (4 alternative transcripts): 
    NM_001042539.2  NM_001276275.1  NM_001276276.1  NM_002383.3  

    Unigene Cluster for MAZ:

    MYC-associated zinc finger protein (purine-binding transcription factor)
    Hs.23650  [show with all ESTs]
    Unigene Representative Sequence: NM_001042539
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000545521(uc010vdx.2) ENST00000322945(uc002dty.3) ENST00000562337
    ENST00000566906 ENST00000563402 ENST00000219782(uc002dtx.3) ENST00000561855
    ENST00000567444 ENST00000568411 ENST00000563012 ENST00000562557 ENST00000568544
    ENST00000569978 ENST00000568282 ENST00000565777 ENST00000562594 ENST00000568516

    miRNA
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    Block miRNA regulation of human, mouse, rat MAZ using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAZ (see all 32):
    hsa-miR-328 hsa-miR-29a hsa-miR-449a hsa-miR-3150b-3p hsa-miR-3909 hsa-miR-615-5p hsa-miR-34c-5p hsa-miR-1237
    SwitchGear 3'UTR luciferase reporter plasmidMAZ 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MAZ
    Clone
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    OriGene ORF clones in mouse, rat for MAZ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MAZ (NM_002383)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAZ
    Primer
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    OriGene qPCR primer pairs and template standards for MAZ
    OriGene qSTAR qPCR primer pairs in human, mouse for MAZ
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAZ
      QuantiTect SYBR Green Assays in human, mouse, rat MAZ
      QuantiFast Probe-based Assays in human, mouse, rat MAZ

    Additional mRNA sequence: 

    AF489858.1 AK074720.1 AK097472.1 BC039057.1 BC041629.1 D85131.1 EF059746.1 FJ532357.1 
    L01420.1 M93339.1 M94046.1 NR_074080.1 U33819.1 

    Selected DOTS entries (see all 47):

    DT.95273488  DT.91710384  DT.100847254  DT.100690986  DT.100765516  DT.92448029  DT.95273487  DT.70103273 
    DT.100039732  DT.100651885  DT.92448013  DT.92448015  DT.100039729  DT.70100793  DT.95149184  DT.100651875 
    DT.95273481  DT.100061000  DT.100832590  DT.100772705  DT.100651881  DT.100651886  DT.100866101  DT.120697569 

    Selected AceView cDNA sequences (see all 466):

    CR621035 BU147419 CR609029 AI498012 BM718738 CR620810 BI092498 BM797712 
    BM720601 BM129635 BQ056701 CA426222 BM557856 BU728796 AW160502 CR592729 
    AI929724 BM552314 CF130948 BQ233167 BQ216135 BM772874 BM842571 CR605757 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAZ (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
    SP1:                                      -     -     -     -     -           -           -     -           -     -     -         
    SP2:                                      -     -     -     -     -           -           -     -                                 
    SP3:                                      -     -     -     -     -           -           -                                       
    SP4:                                            -     -     -     -           -           -     -                                 
    SP5:                                                  -     -     -           -           -                                       


    ECgene alternative splicing isoforms for MAZ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MAZ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCCCACCC
    MAZ Expression
    About this image


    MAZ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
    MAZ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAZ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.23650

    UniProtKB/Swiss-Prot: MAZ_HUMAN, P56270
    Tissue specificity: Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and
    midfrontal cortex (at protein level)

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    QuantiFast Probe-based Assays in human, mouse, rat MAZ
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAZ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MAZ gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Maz1 , 5 MYC-associated zinc finger protein (purine-binding more1, 5 93.21(n)1
    98.36(a)1
      7 (69.28 cM)5
    171881  NM_010772.11  NP_034902.11 
     1270221435 
    lizard
    (Anolis carolinensis)
    Reptilia MAZ6
    MYC-associated zinc finger protein (purine-binding...
    52(a)
    1 ↔ 1
    GL343279.1(224366-242872)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3984912 Myc-associated zinc finger protein 75.01(n)    AF060488.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001487001 myc-associated zinc finger protein-like 64.07(n)
    59.66(a)
      100148700  XM_001920872.4  XP_001920907.1 


    ENSEMBL Gene Tree for MAZ (if available)
    TreeFam Gene Tree for MAZ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAZ gene
    VEZF12  PATZ12  
    Selected SIMAP similar genes for MAZ using alignment to 13 protein entries:     MAZ_HUMAN (see all proteins) (see all similar genes):
    VEZF1    ZNF148    ZNF516    ZNF55    A-328A3.4    ZNF219
    kr-znf3    GZF1    ZNF808    ZNF263    ZNF600    ZNF740
    ZNF778    BCL6B    ZNF19    ZNF22    ZNF253    KLF4

    Find genes that share paralogs with MAZ           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAZ (see all 63)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1128196981,2
    C--29817853(+) CCCTCC/TTTTCC 5 -- us2k1 int10--------
    rs1119936401,2
    C--29817998(+) AGCCCT/CGGGGG 5 -- ut51 int1 nc-transcript-variant1Minor allele frequency- C:0.00NA 120
    rs2003897651,2
    --29818116(+) CCTTCC/TCGCCA 8 P S nc-transcript-variantmis1 int10--------
    rs1995393241,2
    --29818231(+) CGGCCA/GCGGCG 5 -- int10--------
    rs2015510851,2
    C--29818602(+) TCGTAA/GCCCCA 8 T A int1 mis10--------
    rs2002796751,2
    C--29818634(+) CCGGTC/TGCGTC 8 V int1 syn10--------
    rs2005195361,2
    --29818637(+) GTCGCA/GTCTGC 8 A int1 syn10--------
    rs2001578281,2
    --29818652(+) GAGAAA/GAAGAC 8 K int1 syn10--------
    rs1400851041,2
    C--29818709(+) AAGAAC/TGGCTA 8 N syn1 int10--------
    rs2019613091,2
    C--29818793(+) CCGACC/TATGGT 8 T int1 syn10--------

    HapMap Linkage Disequilibrium report for MAZ (29817427 - 29823649 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MAZ:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2667n71CNV Loss21882294
    esv22680CNV Loss19812545
    dgv34n68CNV Loss17160897
    nsv833186CNV Loss17160897
    nsv827611CNV Gain20364138
    nsv827610CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MAZ
    DNA2.0 Custom Variant and Variant Library Synthesis for MAZ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600999    OMIM disorders: --


    Find genes that share disorders with MAZ           About GenesLikeMe

    8 Novoseek inferred disease relationships for MAZ gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amyloidosis 53 2 12270922 (1), 15067082 (1)
    carcinoma embryonal 46.8 1 9294605 (1)
    atherosclerosis 27 3 12270922 (1), 15498774 (1), 15067082 (1)
    arthritis 25.5 3 15498774 (1), 15067082 (1), 17237427 (1)
    rheumatoid arthritis 1.93 1 12270922 (1)
    inflammation 0 4 19583771 (1), 17237427 (1), 19028685 (1)
    colorectal cancer 0 1 12509857 (1)
    tumors 0 4 17849429 (1), 16414245 (1), 17553155 (1), 17102092 (1)

    Genetic Association Database (GAD): MAZ
    Human Genome Epidemiology (HuGE) Navigator: MAZ (1 document)

    Export disorders for MAZ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAZ gene, integrated from 10 sources (see all 86):
    (articles sorted by number of sources associating them with MAZ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination. (PubMed id 1502157)1, 2, 3, 9 Bossone S.A.... Marcu K.B. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    2. Isolation of a novel cDNA encoding a zinc-finger protein that binds to two sites within the c-myc promoter. (PubMed id 1567856)1, 2, 3, 9 Pyrc J.J.... Hall D.J. (Biochemistry 1992)
    3. SAF-2, a splice variant of SAF-1, acts as a negative regulator of transcription. (PubMed id 12270922)1, 2, 9 Ray B.K.... Ray A. (J. Biol. Chem. 2002)
    4. Members of the MAZ family: a novel cDNA clone for MAZ from human pancreatic islet cells. (PubMed id 8831693)1, 2, 9 Tsutsui H.... Yokoyama K.K. (Biochem. Biophys. Res. Commun. 1996)
    5. The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1. (PubMed id 8626793)1, 2, 9 Parks C.L. and Shenk T. (J. Biol. Chem. 1996)
    6. SAF-3, a novel splice variant of the SAF-1/MAZ/Pur-1 family, is expressed during inflammation. (PubMed id 19583771)1, 2, 9 Ray A.... Ray B.K. (FEBS J. 2009)
    7. Genomic organization and expression of a human gene for Myc- associated zinc finger protein (MAZ). (PubMed id 9685418)1, 2, 9 Song J.... Yokoyama K.K. (J. Biol. Chem. 1998)
    8. Association and mutation analyses of 16p11.2 autism candidate genes. (PubMed id 19242545)1, 4 Kumar R.A....Christian S.L. (PLoS ONE 2009)
    9. Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity. (PubMed id 10727212)1, 2 Jordan-Sciutto K.L....Bowser R. (Biochemistry 2000)
    10. Transcriptional synergy mediated by SAF-1 and AP-1: critical role of N-terminal polyalanine and two zinc finger domains of SAF-1. (PubMed id 19028685)1, 9 Kumar D....Ray B.K. (J. Biol. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4150 HGNC: 6914 AceView: MAZ Ensembl:ENSG00000103495 euGenes: HUgn4150
    ECgene: MAZ H-InvDB: MAZ

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAZ Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAZ Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAZ gene:
    Search GeneIP for patents involving MAZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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