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MAX Gene

protein-coding GIFtS: 65

GC14M064542

MYC associated factor X
(Previous name: MAX protein )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC10775 ^²
MGC11225 ^²
MGC18164 ^²
MGC34679 ^²
MGC36767 ^²
bHLHd4 ^¹, ²
bHLHd5 ^¹, ²
bHLHd6 ^¹, ²
bHLHd7 ^¹, ²
bHLHd8 ^¹, ²
orf1 ^²

Descriptions
MAX protein ^¹, ²
MYC associated factor X ^²
Myc-associated factor X ^², ³
helix-loop-helix zipper protein ^²

External Ids
HGNC: 6913¹
Entrez Gene: 4149²
UniProtKB: P61244³
Ensembl: ENSG00000125952⁷

Search outside databases for aliases for MAX gene

Previous GC identifers: GC14M062799 GC14M059335 GC14M063462 GC14M063531

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MAX:

The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ)

family of transcription factors. It is able to form homodimers and heterodimers with other family

members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation,

differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target

site (the E box) and rearrangement among these dimer forms provides a complex system of

transcriptional regulation. Multiple alternatively spliced transcript variants have been described

for this gene but the full-length nature for some of them is unknown. [provided by RefSeq]

UniProtKB/Swiss-Prot: MAX_HUMAN, P61244

Function: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC

or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a

transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription

via the recruitment of a chromatin remodeling complex containing H3-K9 histone methyltransferase

activity

Gene Wiki entry for MAX

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MAX gene

Entrez Gene cytogenetic band: 14q23 Ensembl cytogenetic band: 14q23.3 HGNC cytogenetic band: 14q23

MAX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M064542: (about GC identifiers)

Start:	64,542,645 bp from pter
End:	64,638,980 bp from pter
Size:	96,336 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MAX_HUMAN, P61244 (See protein sequence)

Recommended Name: Protein max

Size: 160 amino acids; 18275 Da

Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a

heterodimer with MYC or MAD. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA,

MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with SPAG9

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1AN2 (3D)

1HLO (3D)

1NKP (3D)

1NLW (3D)

1R05 (3D)

Secondary accessions: P25912 P52163

Alternative splicing: 3 isoforms: P61244-1, P25912-1 P61244-2, P25912-2 P61244-3, P25912-3 (Additional isoforms seem to exist)

Post-translational modifications:

Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max

complexes¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (6 alternative transcripts):

NP_002373.3 NP_660087.1 NP_660088.1 NP_660089.1 NP_660092.1 NP_932061.1

ENSEMBL proteins:

ENSP00000246163 ENSP00000378104 ENSP00000284165 ENSP00000351490 ENSP00000351175 ENSP00000342482

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MAX)
	Human Recombinant Proteins from Abnova (MAX)

OriGene Purified Recombinant Human Proteins (see all 3): MAX

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for MAX:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for MAX
	R&D Systems Antibodies for MAX
	Cell Signaling Technology (CST) Antibodies for MAX
	Antibodies from Abcam (MAX), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MAX)
	Novus Biologicals Antibodies for MAX

Assays for MAX:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P61244

ProtoNet protein and cluster: P61244

UniProtKB/Swiss-Prot: MAX_HUMAN, P61244

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAX)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MAX)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 8): NM_145112

Applied Biosystems Silencer® siRNAs for MAX

Sigma-Aldrich siRNA for MAX

Sigma-Aldrich shRNA for MAX

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MAX
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_002382
Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_002382
untagged cDNA clones in CMV expression vector (see all 8): BC003525

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002382

UniProtKB/Swiss-Prot: MAX_HUMAN, P61244

Function: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC

or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a

transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription

via the recruitment of a chromatin remodeling complex containing H3-K9 histone methyltransferase

activity

Genatlas biochemistry entry for MAX:

Max protein,heterodimerizing with MYC,with high affinity for the DNA-binding site of MYC,binds to

MAD and MNT

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Max):

embryogenesis

growth/size

lethality-prenatal/perinatal

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	2006410
GO:0003713	transcription coactivator activity	TAS	2006410
GO:0005515	protein binding	IPI	17157259 17274640 17418410

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for MAX (Your Favorite Gene powered by Ingenuity)

Small Cell Lung Cancer Signaling
p38 MAPK Signaling
Molecular Mechanisms of Cancer
Cell Cycle: G1/S Checkpoint Regulation
Polyamine Regulation in Colon Cancer

GeneDecks MAX for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for MAX

5/45 Interacting proteins for MAX (P61244^{1, 2} ENSP00000284165³) via UniProtKB, MINT, and/or STRING (see all 45 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAD1L1	Q9Y6D9¹, ENSP00000265854³	EBI-878388, EBI-742610 STRING (score=.97)
MYC	P01106¹^,², ENSP00000367207³	EBI-878388, EBI-447544 MINT-25075 MINT-73406 MINT-73138 EBI-878388, EBI-447544 MINT-25075 MINT-73406 MINT-73138 STRING (score=.999)
EPAS1	Q99814¹	EBI-878388, EBI-447470
HIF1A	Q16665¹	EBI-878388, EBI-447269
PPP1CA	P62136¹	EBI-878388, EBI-357253

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006366	transcription from RNA polymerase II promoter	TAS	8425218

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MAX
3 Novoseek chemical compound relationships for MAX gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leucine	71.72	20	7577944 (3), 1408152 (2), 15121849 (2), 8423990 (2) (see all 14)
lysine	14.59	1	17217336 (1)
forskolin	7.57	1	9886493 (1)

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2 PharmGKB drug compound relationships for MAX gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
mercaptopurine	PD FA GN	12704389
methotrexate	PD FA GN	12704389

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAX)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MAX)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 8): NM_145112

Sigma-Aldrich siRNA for MAX

Sigma-Aldrich shRNA for MAX

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002382 NM_145112 NM_145113 NM_145114 NM_145116 NM_197957

REFSEQ mRNAs for MAX gene (6 alternative transcripts):

NM_002382.3 NM_145112.1 NM_145113.1 NM_145114.1 NM_145116.1 NM_197957.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002382 NM_145112 NM_145113 NM_145114 NM_145116 NM_197957

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_002382
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_002382
                                 untagged cDNA clones in CMV expression vector (see all 8): BC003525

Additional cDNA sequence:

AK290130.1 AK290929.1 AK292189.1 AK292630.1 AK303412.1 AL833643.1 AY353088.1 BC003525.1

BC004516.2 BC013669.1 BC025685.1 BC027924.1 BC036092.1 CR542191.1 CR600362.1 CR607503.1

CR619150.1 M64240.1 X60287.1

24/25 DOTS entries (see all 25 ):

DT.95378414 DT.100037470 DT.100817243 DT.95122128 DT.100817250 DT.98131674 DT.100809293 DT.406416

DT.97853570 DT.120751852 DT.100758256 DT.70103755 DT.95263923 DT.91766090 DT.100817246 DT.120751700

DT.100802547 DT.120751516 DT.120751826 DT.100721347 DT.100817237 DT.120751794 DT.91766088 DT.97818560

24/306 AceView cDNA sequences (see all 306 ):

CR542191 NM_145112 BQ430011 AY353088 T16249 F06832 BF196519 BM141881

AW614081 AL603003 AA053315 CA439543 AI655674 F05304 BQ067185 AI571377

NM_145114 CR607503 BC025685 BF941314 AW006411 AI141211 NM_145113 AI804933

highest scoring ESTs for MAX:

AI693307 X60287 AA614463 AI652319 AI655674 AI917842 AL601562 AL603003 AL691693 AL709228

Unigene Cluster for MAX:

MYC associated factor X

Hs.285354 [show with all ESTs]

Unigene Representative Sequence: BC036092

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for MAX

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	·	6c
SP1:							-				-				-
SP2:							-				-
SP3:							-				-		-		-
SP4:							-
SP5:

About this scheme

ECgene alternative splicing isoforms for MAX

6 Ensembl transcripts including schematic representations:

ENST00000246163 ENST00000394606 ENST00000284165 ENST00000358664 ENST00000358402 ENST00000341653

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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MAX expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MAX

¹ / ² / ³

16 probe-sets matching MAX gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
422_s_at²^{, 3}	U95-A	1	1.00	1.00	0.60	0.91	X66867	0.20	1.00	0.72	1
63606_at²^{, 3}	U95-C	1	1.00	1.00	0.92	1.49	R42375	0.40	1.00	0.76	1
50228_at²^{, 3}	U95-B	1	1.00	1.00	0.87	1.48	AA992592	0.60	1.00	0.82	1
1981_s_at²^{, 3}	U95-A	1	1.00	1.00	0.69	0.74	X60287	1.00	1.00	1.00	1
713_at²^{, 3}	U95-A	1	1.00	1.00	-0.04	1.02	HG2525-HT2621	0.20	1.00	0.72	1
39948_at²^{, 3}	U95-A	1	0.94	1.00	0.89	0.41	AI693307	1.00	1.00	1.00	1
209331_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA723514	0.40	1.00	0.76	1
209332_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC003525	0.80	1.00	0.91	1
210734_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M64240	0.80	1.00	0.91	1
208403_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002382	0.60	1.00	0.82	1
214108_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI346181	0.60	1.00	0.82	1
209331_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209332_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210734_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208403_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214108_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks MAX for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.285354
Expression variation in blood from EXPOLDB for MAX
UniProtKB/Swiss-Prot: MAX_HUMAN, P61244
Tissue specificity: High levels found in the brain, heart and lung while lower levels are seen in
the liver, kidney and skeletal muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MAX gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MAX¹	--	MYC associated factor X	98.33(n) 100(a)	609969 XM_847808.1 XP_852901.1
chimpanzee (Pan troglodytes)	MAX¹	--	MYC associated factor X	100(n) 100(a)	452972 XM_510008.2 XP_510008.2
cow (Bos taurus)	MAX¹	--	MYC associated factor X	98.06(n) 99.03(a)	540616 XM_612347.3 XP_612347.3
rat (Rattus norvegicus)	Max¹	--	MYC associated factor X	95.83(n) 98.75(a)	60661 NM_022210.1 NP_071546.1
mouse (Mus musculus)	Max^{1, 5}	12 (32.00 cM)⁵	Max protein^{1, 5}	95.62(n)¹ 98.12(a)¹	17187¹ NM_008558.1¹ NP_032584.1¹ AA960152⁵ AI875693⁵ (see all 14)

About this table Species with no ortholog for MAX

ENSEMBL Gene Tree for MAX

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/171 NCBI SNPs in MAX are shown (see all 171 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 144)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1957949^1,2	A,C,F,H,O	64612360(-)	`AAAAGA/GAAGTG`	4	--	int¹ ut3¹ trp³		11	NA EU EA WA	982
	rs942627^1,2	A,C,F,H,O	64619778(-)	`TTCTAT/CTTAGA`	6	--	int¹ ng5¹		13	EA NA EU WA	868
	rs1957948^1,2	A,C,F,H,O	64612382(-)	`CCTTAA/GAGAAG`	4	--	ut3¹ int¹		16	EA NA EU WA	1420
	rs1953232^1,2	A,C,F,H	64640139(+)	`TTCCAA/CCCTGA`	6	--	ng3¹		9	MN EU EA WA	1022
	rs4902359^1,2	A,C,F,H	64612543(+)	`AGGGCA/GGGCCA`	4	--	int¹ ut3¹ ese³		7	NA EU EA WA	552
	rs4902358^1,2	A,C,F,H	64612230(+)	`CTGCCA/GTCTCC`	4	--	ut3¹ int¹		12	MN NA EU EA WA	1158
	rs1953230^1,2	A,C,F,H	64639790(+)	`GGAAGT/CAAAAG`	6	--	ng3¹		5	MN EU EA WA	602
	rs7159443^1,2	A,C,F,H	64620569(+)	`CAGGGT/AAAGGC`	6	--	int¹ ut3¹ ese³		5	MN EU EA WA	594
	rs762810^1,2	A,C,F,H	64614120(-)	`TTGGGG/TCTCAG`	5	--	int¹ ng5¹ ese³		7	EA EU	1890
	rs4902357^1,2	A,C,F,H	64611820(+)	`ACTGGG/CATCTG`	4	--	int¹ ut3¹ ese³		12	MN NA EU EA WA	1146

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HapMap Linkage Disequilibrium images for MAX (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 154950

4 Novoseek disease relationships for MAX gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia	28.02	1	7731722 (1)
pheochromocytoma	13.20	3	7791753 (2)
tumors	10.81	10	9018122 (4), 16908182 (1), 7791753 (1), 10229497 (1)
cancer	0.00	1	18493233 (1)

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1 PharmGKB disease relationship for MAX gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	PD FA GN	12704389

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Human Genome Epidemiology Navigator: MAX (86 documents)
Tumor Gene Database: MAX

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/128 PubMed articles for MAX gene (see all 128 ):

Max is acetylated by p300 at several nuclear localization residues. (PubMed id 17217336)^{1, 3, 4} Faiola F.... Martinez E. (2007)
Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. (PubMed id 2006410)^{1, 3, 4} Blackwood E.M. and Eisenman R.N. (1991)
The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control. (PubMed id 9115440)^{1, 3, 4} Brownlie P....Suck D. (1997)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{3, 4} Hillman R.T.... Brenner S.E. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. (PubMed id 12004135)^{3, 4} Ogawa H....Nakatani Y. (2002)
Alternative mRNA forms and open reading frames of the max gene. (PubMed id 8426752)^{3, 4} Vaestrik I.... Maekelae T.P. (1993)
Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain. (PubMed id 8479534)^{3, 4} Ferre-D'Amare A.R.... Burley S.K. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4149	HGNC: 6913	AceView: MAX	Ensembl:ENSG00000125952	euGenes: HUgn4149
ECgene: MAX	H-InvDB: MAX

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MAX	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for MAX
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MAX:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MAX-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MAX		Antibodies for MAX
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MAX		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MAX)
	Antibodies (MAX)
	Chimera RNAi (MAX)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for MAX

	Recombinant Proteins (MAX)
	Antibodies (MAX)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for MAX

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MAX

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
MAX Gene at Home site.
Version 2.41.1
server5.xennexinc.com

MAX Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for MAX

Summaries
for MAX

Genomic Location
for MAX

Proteins
for MAX

Protein Domains/
Families
for MAX

Gene Function
for MAX

Pathways & Interactions
for MAX

Drugs & Compounds
for MAX

Transcripts
for MAX

Expression
for MAX

Orthologs
for MAX

Paralogs
for MAX

SNPs/Variants
for MAX

Disorders & Mutations
for MAX

Medical News
for MAX

Publications
for MAX

Search for MAX

Genome Databases showing MAX

Other Databases showing MAX

Specialized Databases showing MAX

Licensable Technologies
for MAX

Services
for MAX

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MAX Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor MAX

Summariesfor MAX

Genomic Locationfor MAX

Proteinsfor MAX

Protein Domains/Familiesfor MAX

Gene Functionfor MAX

Pathways & Interactionsfor MAX

Drugs & Compoundsfor MAX

Transcriptsfor MAX

Expression for MAX

Orthologsfor MAX

Paralogsfor MAX

SNPs/Variantsfor MAX

Disorders & Mutationsfor MAX

Medical Newsfor MAX

Publicationsfor MAX

Search for MAX

Genome Databases showing MAX

Other Databases showing MAX

Specialized Databases showing MAX

Licensable Technologiesfor MAX

Servicesfor MAX

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MAX

Summaries
for MAX

Genomic Location
for MAX

Proteins
for MAX

Protein Domains/
Families
for MAX

Gene Function
for MAX

Pathways & Interactions
for MAX

Drugs & Compounds
for MAX

Transcripts
for MAX

Expression
for MAX

Orthologs
for MAX

Paralogs
for MAX

SNPs/Variants
for MAX

Disorders & Mutations
for MAX

Medical News
for MAX

Publications
for MAX

Licensable Technologies
for MAX

Services
for MAX