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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAX Gene

protein-coding   GIFtS: 64
GCID: GC14M065472

MYC Associated Factor X

(Previous name: MAX protein)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MYC Associated Factor X1 2     Protein Max2
Class D Basic Helix-Loop-Helix Protein 42 3     BHLHD43
bHLHd42 3     Myc-Associated Factor X3
MAX Protein1     

External Ids:    HGNC: 69131   Entrez Gene: 41492   Ensembl: ENSG000001259527   OMIM: 1549505   UniProtKB: P612443   

Export aliases for MAX gene to outside databases

Previous GC identifers: GC14M062799 GC14M059335 GC14M063462 GC14M063531 GC14M064542 GC14M045642


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAX Gene:
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of
transcription factors. It is able to form homodimers and heterodimers with other family members, which include
Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The
homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer
forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be
associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome
7. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2012)

GeneCards Summary for MAX Gene: 
MAX (MYC associated factor X) is a protein-coding gene. Diseases associated with MAX include female stress incontinence, and max-related susceptibility to pheochromocytoma, and among its related super-pathways are MAPK signaling pathway and Rho Family GTPases. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: MAX_HUMAN, P61244
Function: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which
recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the
MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex
containing H3 'Lys-9' histone methyltransferase activity

Gene Wiki entry for MAX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAX gene promoter:
         C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAX promoter sequence
   Search SABiosciences Chromatin IP Primers for MAX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q23

MAX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAX gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M065472:  view genomic region     (about GC identifiers)

Start:
65,472,892 bp from pter      End:
65,569,413 bp from pter
Size:
96,522 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MAX_HUMAN, P61244 (See protein sequence)
Recommended Name: Protein max  
Size: 160 amino acids; 18275 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with
MYC or MAD. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1,
RING1, RNF2, MBLR, L3MBTL2 and YAF2. Component of some MLL1/MLL complex, at least composed of the core components
KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70,
INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3,
TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with SPAG9
Subcellular location: Nucleus
5 PDB 3D structures from and Proteopedia for MAX:
1AN2 (3D)        1HLO (3D)        1NKP (3D)        1NLW (3D)        1R05 (3D)    
Secondary accessions: A6NH73 A8K265 A8K4G4 A8K824 P25912 P52163 Q14803 Q96CY8
Alternative splicing: 6 isoforms:  P61244-1, P25912-1   P61244-2, P25912-2   P61244-3, P25912-3   P61244-4   P61244-5   P61244-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAX: NX_P61244

Explore proteomics data for MAX at MOPED 

Post-translational modifications:

  • UniProtKB: Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max complexes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P61244

  • MAX Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAX Protein Expression
    REFSEQ proteins (7 alternative transcripts): 
    NP_001257997.1  NP_001257998.1  NP_002373.3  NP_660087.1  NP_660088.1  NP_660089.1  NP_932061.1  

    ENSEMBL proteins: 
     ENSP00000342482   ENSP00000351175   ENSP00000378104   ENSP00000450763   ENSP00000284165  
     ENSP00000351490   ENSP00000452405   ENSP00000451907   ENSP00000450955   ENSP00000452206  
     ENSP00000452378   ENSP00000452286   ENSP00000452197   ENSP00000450818   ENSP00000246163  

    Human Recombinant Protein Products for MAX: 
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    OriGene Purified Proteins for MAX
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    OriGene MassSpec for MAX 
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    GenScript Custom Purified and Recombinant Proteins Services for MAX
    Novus Biologicals MAX Proteins
    Novus Biologicals MAX Lysates
    Sino Biological Recombinant Protein for MAX
    Sino Biological Cell Lysate for MAX 
    ProSpec Recombinant Protein for MAX
    Cloud-Clone Corp. Proteins for MAX 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016605PML body IEA--
    GO:0030425dendrite IEA--

    MAX for ontologies           About GeneDecksing



    MAX Antibody Products: 
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    Novus Biologicals MAX Antibodies
    Abcam antibodies for MAX
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    ThermoFisher Antibodies for MAX
    LSBio Antibodies in human, mouse, rat for MAX 

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    GenScript Custom Assay Services for MAX
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAX 
    Cloud-Clone Corp. CLIAs for MAX


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry P61244

    ProtoNet protein and cluster: P61244

    UniProtKB/Swiss-Prot: MAX_HUMAN, P61244
    Similarity: Belongs to the MAX family
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    MAX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAX_HUMAN, P61244
    Function: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which
    recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the
    MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex
    containing H3 'Lys-9' histone methyltransferase activity

         Genatlas biochemistry entry for MAX:
    Max protein,heterodimerizing with MYC,with high affinity for the DNA-binding site of MYC,binds to MAD and MNT

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003712transcription cofactor activity TAS8425218
    GO:0003713transcription coactivator activity TAS2006410
    GO:0005515protein binding IPI10597290
         
    MAX for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for MAX:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella enterica   Decreased Salmonella-containin  Synthetic lethal with c-Myc af 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Max):
     cellular  embryogenesis  growth/size  mortality/aging 

    MAX for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Maxtm1Rdp for MAX

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAX 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAX 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAX 

    miRNA
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    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate MAX (see all 22):
    hsa-miR-19b-2* hsa-miR-137 hsa-miR-218-2* hsa-miR-624* hsa-miR-138-2* hsa-miR-888* hsa-miR-10b* hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidMAX 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of MAX

    Clone
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    OriGene ORF clones in mouse, rat for MAX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): MAX (NM_197957)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAX
    Sirion Biotech Customized lentivirus for stable overexpression of MAX 
                         Customized lentivirus expression plasmids for stable overexpression of MAX 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAX


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAX About   (see all 17)                                                                                              See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Rho Family GTPases
    ERK Signaling0.61
    Molecular Mechanisms of Cancer0.51
    3Akt Signaling
    p38 Signaling0.60
    4Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
    Adipocytokines & Insulin Signaling0.34
    5p38 MAPK Signaling Pathway
    p38 MAPK Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for MAX
        Adipocytokines & Insulin Signaling
    TGF-beta Signaling Pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAX
        ERK Signaling
    Molecular Mechanisms of Cancer
    p38 Signaling

    1 Cell Signaling Technology (CST) Pathway for MAX
        Apoptosis and Autophagy

    5/9 BioSystems Pathways for MAX (see all 9)
        MAPK signaling pathway
    p38 MAPK Signaling Pathway
    Integrated Breast Cancer Pathway
    Signaling events mediated by HDAC Class I
    Regulation of nuclear SMAD2/3 signaling



    4         Kegg Pathways  (Kegg details for MAX):
        MAPK signaling pathway
    Pathways in cancer
    Transcriptional misregulation in cancer
    Small cell lung cancer


    MAX for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/286 Interacting proteins for MAX (P612441, 2, 3 ENSP000003514904) via UniProtKB, MINT, STRING, and/or I2D (see all 286)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS8425218
    GO:0006461protein complex assembly IEA--
    GO:0009267cellular response to starvation IEA--
    GO:0010243response to organonitrogen compound ----

    MAX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAX for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAX

    3 Novoseek inferred chemical compound relationships for MAX gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 72.4 22 7577944 (3), 1408152 (2), 15121849 (2), 8423990 (2) (see all 15)
    lysine 13.1 1 17217336 (1)
    forskolin 6.59 1 9886493 (1)

    Search CenterWatch for drugs/clinical trials and news about MAX

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAX gene (8 alternative transcripts): 
    NM_001271068.1  NM_001271069.1  NM_002382.4  NM_145112.2  NM_145113.2  NM_145114.2  NM_197957.3  NM_145116.1  

    Unigene Cluster for MAX:

    MYC associated factor X
    Hs.285354  [show with all ESTs]
    Unigene Representative Sequence: BC036092
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341653 ENST00000358402 ENST00000394606(uc001xie.1 uc001xif.1 uc001xig.1 uc001xih.1)
    ENST00000555932 ENST00000284165(uc001xij.1) ENST00000358664 ENST00000555419
    ENST00000553928 ENST00000557277 ENST00000556892 ENST00000553951 ENST00000556979(uc001xic.1)
    ENST00000555667(uc001xii.1) ENST00000557746 ENST00000556443 ENST00000246163(uc001xik.3)
    ENST00000556702 ENST00000554709
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate MAX (see all 22):
    hsa-miR-19b-2* hsa-miR-137 hsa-miR-218-2* hsa-miR-624* hsa-miR-138-2* hsa-miR-888* hsa-miR-10b* hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidMAX 3' UTR sequence
    Inhib. RNA
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAX
    Sirion Biotech Customized lentivirus for stable overexpression of MAX 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAX

    Additional mRNA sequence: 

    AK290130.1 AK290929.1 AK292189.1 AK292630.1 AK303412.1 AL833643.1 AY353088.1 BC003525.1 
    BC004516.2 BC013669.1 BC025685.1 BC027924.1 BC036092.1 CR542191.1 M64240.1 NR_073137.1 
    NR_073138.1 X60287.1 

    24/27 DOTS entries (see all 27):

    DT.95378414  DT.100037470  DT.100817243  DT.95122128  DT.100817250  DT.98131674  DT.100809293  DT.406416 
    DT.97853570  DT.120751852  DT.100758256  DT.70103755  DT.95263923  DT.91766090  DT.100817246  DT.120751700 
    DT.100802547  DT.120751516  DT.120751826  DT.95371931  DT.100037465  DT.100721347  DT.100817237  DT.120751794 

    24/306 AceView cDNA sequences (see all 306):

    BE048876 BF002710 AA554069 AI141211 T16249 CR607503 NM_145112 BQ441916 
    AI571377 BM989983 NM_145113 NM_145114 AW242767 F06832 H14126 BM710151 
    CA439543 AA053315 BE048092 BM988794 AL603003 AA535616 BQ430011 BF941314 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MAX    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:                    -           -           -                     
    SP2:                    -           -                                 
    SP3:                    -           -     -     -                     
    SP4:                    -                                             
    SP5:                                                                  


    ECgene alternative splicing isoforms for MAX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATAAAAA
    MAX Expression
    About this image


    See MAX Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAX

    SOURCE GeneReport for Unigene cluster: Hs.285354

    UniProtKB/Swiss-Prot: MAX_HUMAN, P61244
    Tissue specificity: High levels found in the brain, heart and lung while lower levels are seen in the liver,
    kidney and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAX: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Transcription Factors in human mouse rat
              Prostate Cancer in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAX
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MAX gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Max1 , 5 Max protein1, 5 96.04(n)1
    99.37(a)1
      12 (33.78 cM)5
    171871  NM_008558.21  NP_032584.21 
     769372695 
    chicken
    (Gallus gallus)
    Aves LOC1008586761 protein max-like 84.17(n)
    94.96(a)
      100858676  XM_003643508.1  XP_003643556.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia max-A2 MAX protein 84.37(n)    L04924.1 
    zebrafish
    (Danio rerio)
    Actinopterygii max2 myc-associated factor X 84.03(n)   30467  BC044453.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Max1 CG9648-PA 61.59(n)
    60.95(a)
      40095  NM_140840.3  NP_649097.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mxl-16
    mxl-36
    Protein MXL-3
    31(a)
    23(a)
    many → 1
    many → 1
    V(11244839-11245928)
    X(13349640-13350806)


    ENSEMBL Gene Tree for MAX (if available)
    TreeFam Gene Tree for MAX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAX gene
    13 SIMAP similar genes for MAX using alignment to 10 protein entries:     MAX_HUMAN (see all proteins):
    MYCL1    SREBF1    MYCL1P1    N-myc    MYC    USF1
    usf1-bd    MLX    TFAP4    MXD1    SREBF2    USF2
    KIAA2018

    MAX for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MAX
    PGOHUM00000233579


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1867 SNPs in MAX are shown (see all 1867)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1489691871,2
    --46455890(+) CGGTCC/TTGCCC 2 -- ds50010--------
    rs786436861,2
    C,F--46456007(+) GCCTCC/TGCAGT 2 -- ds50011Minor allele frequency- T:0.03EA 120
    rs1129218421,2
    C,F--46456036(+) ACATCA/TCTATG 2 -- ds50012Minor allele frequency- T:0.18CSA WA 119
    rs1135239731,2
    C,F--46456156(+) GATTAC/TAGCTG 2 -- ds50012Minor allele frequency- T:0.04CSA WA 119
    rs757801231,2
    C,F--46456190(+) GAACAC/TTTTTC 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1910562341,2
    --46456287(+) CCTTCA/GTCATG 2 -- ds50010--------
    rs747811781,2
    C--46456425(+) TTTTTG/TCCACC 2 -- ut310--------
    rs2010521121,2
    C--46456540(+) CCTGGG/TGAAGG 2 -- int11Minor allele frequency- T:0.00EU 1253
    rs1835678271,2
    C--46456558(+) GAAAAA/GTATCA 2 -- int10--------
    rs1878626451,2
    --46456714(+) GAGAAC/GGAGCT 2 -- int10--------

    HapMap Linkage Disequilibrium report for MAX (65472892 - 65569413 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MAX:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748787CNV Deletion23290073
    esv2748789CNV Deletion23290073
    esv2673460CNV Deletion23128226
    esv2748788CNV Deletion23290073
    esv2506970CNV Deletion19546169
    esv2748779CNV Deletion23290073
    esv2665422CNV Deletion23128226
    nsv832816CNV Gain17160897


    Human Gene Mutation Database (HGMD): MAX
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MAX
    DNA2.0 Custom Variant and Variant Library Synthesis for MAX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 154950    OMIM disorders: --

    20/22 diseases for MAX (see all 22):    About MalaCards
    female stress incontinence    max-related susceptibility to pheochromocytoma    max-related hereditary paraganglioma-pheochromocytoma syndrome    hereditary paraganglioma-pheochromocytoma syndromes
    pheochromocytoma    williams-beuren syndrome    paraganglioma    teratocarcinoma
    cholestasis    neuroblastoma    glioblastoma    mental retardation
    melanoma    lung cancer    myeloid leukemia    prostate cancer
    adenocarcinoma    prostatitis    endotheliitis    leukemia


    MAX for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for MAX gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 26.8 1 7731722 (1)
    pheochromocytoma 11.8 3 7791753 (2)
    tumors 8.83 10 9018122 (4), 16908182 (1), 7791753 (1), 10229497 (1)
    cancer 0 1 18493233 (1)

    Genetic Association Database (GAD): MAX
    Human Genome Epidemiology (HuGE) Navigator: MAX (129 documents)
    Tumor Gene Database (TGDB): MAX

    Export disorders for MAX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAX gene, integrated from 9 sources (see all 193):
    (articles sorted by number of sources associating them with MAX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Max is acetylated by p300 at several nuclear localization residues. (PubMed id 17217336)1, 2, 9 Faiola F.... Martinez E. (2007)
    2. Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. (PubMed id 2006410)1, 2, 9 Blackwood E.M. and Eisenman R.N. (1991)
    3. The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control. (PubMed id 9115440)1, 2, 9 Brownlie P....Suck D. (1997)
    4. Genome-wide association study of anthropometric traits in Korcula Island, Croatia. (PubMed id 19260139)1, 4 Polasek O....Rudan I. (2009)
    5. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PubMed id 19862010)1, 4 Ganesh S.K....Lin J.P. (2009)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    8. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (2005)
    9. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4149 HGNC: 6913 AceView: MAX Ensembl:ENSG00000125952 euGenes: HUgn4149
    ECgene: MAX Kegg: 4149 H-InvDB: MAX

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAX Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAX Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAX gene:
    Search GeneIP for patents involving MAX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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