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Aliases for MAX Gene

Aliases for MAX Gene

  • MYC Associated Factor X 2 3 5
  • Class D Basic Helix-Loop-Helix Protein 4 3 4
  • BHLHd4 3 4
  • Myc-Associated Factor X 4
  • MAX Protein 2

External Ids for MAX Gene

Previous GeneCards Identifiers for MAX Gene

  • GC14M062799
  • GC14M059335
  • GC14M063462
  • GC14M063531
  • GC14M064542
  • GC14M065472
  • GC14M045642

Summaries for MAX Gene

Entrez Gene Summary for MAX Gene

  • The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for MAX Gene

MAX (MYC Associated Factor X) is a Protein Coding gene. Diseases associated with MAX include pheochromocytoma and hereditary paraganglioma-pheochromocytoma syndromes. Among its related pathways are MAPK signaling pathway and Pathways in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for MAX Gene

  • Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5-CAC[GA]TG-3. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 Lys-9 histone methyltransferase activity.

Gene Wiki entry for MAX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAX Gene

Genomics for MAX Gene

Regulatory Elements for MAX Gene

Enhancers for MAX Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAX on UCSC Golden Path with GeneCards custom track

Promoters for MAX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAX on UCSC Golden Path with GeneCards custom track

Genomic Location for MAX Gene

Chromosome:
14
Start:
65,006,101 bp from pter
End:
65,102,695 bp from pter
Size:
96,595 bases
Orientation:
Minus strand

Genomic View for MAX Gene

Genes around MAX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAX Gene

Proteins for MAX Gene

  • Protein details for MAX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61244-MAX_HUMAN
    Recommended name:
    Protein max
    Protein Accession:
    P61244
    Secondary Accessions:
    • A6NH73
    • A8K265
    • A8K4G4
    • A8K824
    • P25912
    • P52163
    • Q14803
    • Q96CY8

    Protein attributes for MAX Gene

    Size:
    160 amino acids
    Molecular mass:
    18275 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MYC or MAD. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with SPAG9. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity.

    Three dimensional structures from OCA and Proteopedia for MAX Gene

    Alternative splice isoforms for MAX Gene

neXtProt entry for MAX Gene

Proteomics data for MAX Gene at MOPED

Post-translational modifications for MAX Gene

  • Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max complexes.
  • Ubiquitination at Lys 66
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAX (MAX)

No data available for DME Specific Peptides for MAX Gene

Domains & Families for MAX Gene

Gene Families for MAX Gene

Protein Domains for MAX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAX Gene

Graphical View of Domain Structure for InterPro Entry

P61244

UniProtKB/Swiss-Prot:

MAX_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Belongs to the MAX family.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Family:
  • Belongs to the MAX family.
genes like me logo Genes that share domains with MAX: view

Function for MAX Gene

Molecular function for MAX Gene

GENATLAS Biochemistry:
Max protein,heterodimerizing with MYC,with high affinity for the DNA-binding site of MYC,binds to MAD and MNT
UniProtKB/Swiss-Prot Function:
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5-CAC[GA]TG-3. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 Lys-9 histone methyltransferase activity.

Gene Ontology (GO) - Molecular Function for MAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10597290
GO:0032403 protein complex binding IEA --
GO:0042803 protein homodimerization activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with MAX: view
genes like me logo Genes that share phenotypes with MAX: view

Human Phenotype Ontology for MAX Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MAX Gene

MGI Knock Outs for MAX:

Transcription Factor Targets for MAX Gene

Selected GeneGlobe predicted Target genes for MAX
Targeted motifs for MAX Gene
HOMER Transcription Factor Regulatory Elements motif MAX
  • Consensus sequence: ACCACGTGGTCN Submotif: canonical Cell Type: K562 GEO ID: GSE31477

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) for MAX Gene

Localization for MAX Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAX Gene

Nucleus. Cell projection, dendrite.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAX Gene COMPARTMENTS Subcellular localization image for MAX gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for MAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0016605 PML body IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with MAX: view

Pathways & Interactions for MAX Gene

genes like me logo Genes that share pathways with MAX: view

SIGNOR curated interactions for MAX Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010243 response to organonitrogen compound IEA --
GO:0010629 negative regulation of gene expression IEA --
GO:0060041 retina development in camera-type eye IEA --
GO:0071375 cellular response to peptide hormone stimulus IEA --
genes like me logo Genes that share ontologies with MAX: view

Drugs & Compounds for MAX Gene

(3) Drugs for MAX Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MAX: view

Transcripts for MAX Gene

Unigene Clusters for MAX Gene

MYC associated factor X:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAX Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - -
SP2: - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for MAX Gene

GeneLoc Exon Structure for
MAX
ECgene alternative splicing isoforms for
MAX

Expression for MAX Gene

mRNA expression in normal human tissues for MAX Gene

Protein differential expression in normal tissues from HIPED for MAX Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.0), CD4 Tcells (13.0), and Monocytes (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAX Gene



SOURCE GeneReport for Unigene cluster for MAX Gene Hs.285354

mRNA Expression by UniProt/SwissProt for MAX Gene

P61244-MAX_HUMAN
Tissue specificity: High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
genes like me logo Genes that share expression patterns with MAX: view

Protein tissue co-expression partners for MAX Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MAX Gene

Orthologs for MAX Gene

This gene was present in the common ancestor of animals.

Orthologs for MAX Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAX 35
  • 98.12 (n)
  • 99.37 (a)
MAX 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAX 35
  • 98.33 (n)
  • 100 (a)
MAX 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Max 35
  • 96.04 (n)
  • 99.37 (a)
Max 16
Max 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAX 35
  • 100 (n)
  • 100 (a)
MAX 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Max 35
  • 95.83 (n)
  • 98.75 (a)
oppossum
(Monodelphis domestica)
Mammalia MAX 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAX 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAX 35
  • 84.17 (n)
  • 94.96 (a)
MAX 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia max 35
  • 81.36 (n)
  • 93.7 (a)
Str.4058 35
African clawed frog
(Xenopus laevis)
Amphibia max-A 35
zebrafish
(Danio rerio)
Actinopterygii max 35
  • 79.58 (n)
  • 85 (a)
max 36
  • 82 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11119 35
fruit fly
(Drosophila melanogaster)
Insecta Max 36
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mxl-1 36
  • 35 (a)
OneToMany
mxl-3 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2903 36
  • 57 (a)
OneToOne
Species with no ortholog for MAX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAX Gene

ENSEMBL:
Gene Tree for MAX (if available)
TreeFam:
Gene Tree for MAX (if available)

Paralogs for MAX Gene

Pseudogenes.org Pseudogenes for MAX Gene

genes like me logo Genes that share paralogs with MAX: view

No data available for Paralogs for MAX Gene

Variants for MAX Gene

Sequence variations from dbSNP and Humsavar for MAX Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1271582 -- 65,097,985(-) CAGTT(A/C)TTTTA intron-variant
rs2763887 -- 65,095,030(-) GGATT(A/C)ATGTG intron-variant
rs2781371 -- 65,100,782(+) TTACT(C/G)TCTCA intron-variant
rs2781373 -- 65,101,497(+) AAAAG(A/G)AATAG intron-variant
rs2781374 -- 65,101,845(+) CCCAG(C/T)TCGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAX Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV Deletion 23290073
nsv832816 CNV Gain 17160897
esv2506970 CNV Deletion 19546169
esv2748787 CNV Deletion 23290073
esv2665422 CNV Deletion 23128226
esv2748788 CNV Deletion 23290073
esv2673460 CNV Deletion 23128226
esv2748789 CNV Deletion 23290073

Variation tolerance for MAX Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAX Gene

HapMap Linkage Disequilibrium report
MAX
Human Gene Mutation Database (HGMD)
MAX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAX Gene

Disorders for MAX Gene

MalaCards: The human disease database

(5) MalaCards diseases for MAX Gene - From: OMIM, GeneTests, Orphanet, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search MAX in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAX

Genetic Association Database (GAD)
MAX
Human Genome Epidemiology (HuGE) Navigator
MAX
Tumor Gene Database (TGDB):
MAX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAX
genes like me logo Genes that share disorders with MAX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAX Gene

Publications for MAX Gene

  1. Max is acetylated by p300 at several nuclear localization residues. (PMID: 17217336) Faiola F. … Martinez E. (Biochem. J. 2007) 3 4 23 67
  2. Small-molecule perturbation of competing interactions between c-Myc and Max. (PMID: 19114306) Follis A.V. … Metallo S.J. (Bioorg. Med. Chem. Lett. 2009) 3 23
  3. The mouse C/EBPdelta gene promoter is regulated by STAT3 and Sp1 transcriptional activators, chromatin remodeling and c-Myc repression. (PMID: 17471507) Zhang Y. … DeWille J. (J. Cell. Biochem. 2007) 3 23
  4. The MAX-interacting transcription factor network. (PMID: 16908182) Hurlin P.J. … Huang J. (Semin. Cancer Biol. 2006) 3 23
  5. Phosphorylation regulates Myc expression via prolonged activation of the mitogen-activated protein kinase pathway. (PMID: 16596619) Wang Z. … Carr B.I. (J. Cell. Physiol. 2006) 3 23

Products for MAX Gene

Sources for MAX Gene

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