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MAX Gene

protein-coding   GIFtS: 68
GCID: GC14M065472

MYC Associated Factor X

(Previous name: MAX protein)
  See MAX-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MYC Associated Factor X1 2     Protein Max2
Class D Basic Helix-Loop-Helix Protein 42 3     BHLHD43
bHLHd42 3     Myc-Associated Factor X3
MAX Protein1     

External Ids:    HGNC: 69131   Entrez Gene: 41492   Ensembl: ENSG000001259527   OMIM: 1549505   UniProtKB: P612443   

Export aliases for MAX gene to outside databases

Previous GC identifers: GC14M062799 GC14M059335 GC14M063462 GC14M063531 GC14M064542 GC14M045642


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAX Gene:
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of
transcription factors. It is able to form homodimers and heterodimers with other family members, which include
Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The
homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer
forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be
associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome
7. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2012)

GeneCards Summary for MAX Gene:
MAX (MYC associated factor X) is a protein-coding gene. Diseases associated with MAX include max-related susceptibility to pheochromocytoma, and max-related hereditary paraganglioma-pheochromocytoma syndrome. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: MAX_HUMAN, P61244
Function: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which
recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the
MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex
containing H3 'Lys-9' histone methyltransferase activity

Gene Wiki entry for MAX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAX gene promoter:
         C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAX promoter sequence
   Search Chromatin IP Primers for MAX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q23

MAX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAX gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M065472:  view genomic region     (about GC identifiers)

Start:
65,472,892 bp from pter      End:
65,569,413 bp from pter
Size:
96,522 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MAX_HUMAN, P61244 (See protein sequence)
Recommended Name: Protein max  
Size: 160 amino acids; 18275 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with
MYC or MAD. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1,
RING1, RNF2, MBLR, L3MBTL2 and YAF2. Component of some MLL1/MLL complex, at least composed of the core components
KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70,
INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3,
TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with SPAG9. The heterodimer MYC:MAX interacts with ABI1; the
interaction may enhance MYC:MAX transcriptional activity
5 PDB 3D structures from and Proteopedia for MAX:
1AN2 (3D)        1HLO (3D)        1NKP (3D)        1NLW (3D)        1R05 (3D)    
Secondary accessions: A6NH73 A8K265 A8K4G4 A8K824 P25912 P52163 Q14803 Q96CY8
Alternative splicing: 6 isoforms:  P61244-1, P25912-1   P61244-2, P25912-2   P61244-3, P25912-3   P61244-4   P61244-5   P61244-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAX: NX_P61244

Explore proteomics data for MAX at MOPED

Post-translational modifications: 

  • Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max complexes1
  • Ubiquitination2 at Lys66
  • Modification sites at PhosphoSitePlus

  • See MAX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001257997.1  NP_001257998.1  NP_002373.3  NP_660087.1  NP_660088.1  NP_660089.1  NP_932061.1  

    ENSEMBL proteins: 
     ENSP00000342482   ENSP00000351175   ENSP00000378104   ENSP00000450763   ENSP00000284165  
     ENSP00000351490   ENSP00000452405   ENSP00000451907   ENSP00000450955   ENSP00000452206  
     ENSP00000452378   ENSP00000452286   ENSP00000452197   ENSP00000450818   ENSP00000246163  
    Reactome Protein details: P61244

    MAX Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Proteins for MAX
    OriGene Protein Over-expression Lysate for MAX
    OriGene MassSpec for MAX
    OriGene Custom Protein Services for MAX
    GenScript Custom Purified and Recombinant Proteins Services for MAX
    Novus Biologicals MAX Proteins
    Novus Biologicals MAX Lysates
    Sino Biological Recombinant Protein for MAX
    Sino Biological Cell Lysate for MAX
    ProSpec Recombinant Protein for MAX
    Cloud-Clone Corp. Proteins for MAX

     
    Search eBioscience for Proteins for MAX 

     
    antibodies-online proteins for MAX (21 products) 

     
    antibodies-online peptides for MAX

    MAX Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for MAX
    Cell Signaling Technology (CST) Antibodies for MAX 
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    OriGene Custom Antibody Services for MAX
    Novus Biologicals MAX Antibodies
    Abcam antibodies for MAX
    Cloud-Clone Corp. Antibodies for MAX
    ThermoFisher Antibodies for MAX
    antibodies-online antibodies for MAX (52 products) 

    MAX Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAX
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAX
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAX
    Cloud-Clone Corp. CLIAs for MAX
    Search eBioscience for ELISAs for MAX 
    antibodies-online kits for MAX (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry P61244

    ProtoNet protein and cluster: P61244

    UniProtKB/Swiss-Prot: MAX_HUMAN, P61244
    Similarity: Belongs to the MAX family
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Find genes that share domains with MAX           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAX_HUMAN, P61244
    Function: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which
    recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the
    MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex
    containing H3 'Lys-9' histone methyltransferase activity

         Genatlas biochemistry entry for MAX:
    Max protein,heterodimerizing with MYC,with high affinity for the DNA-binding site of MYC,binds to MAD and MNT

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003712transcription cofactor activity TAS8425218
    GO:0003713transcription coactivator activity TAS2006410
    GO:0005515protein binding IPI10597290
         
    Find genes that share ontologies with MAX           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for MAX:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella enterica   Decreased Salmonella-containin  Synthetic lethal with c-Myc af 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Max):
     cellular  embryogenesis  growth/size/body  mortality/aging 

    Find genes that share phenotypes with MAX           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Maxtm1Rdp for MAX

       genOway: Develop your customized and physiologically relevant rodent model for MAX

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  ACCACGTGGTCN 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAX:
    hsa-mir-193b-3p (MIRT016436)

    Block miRNA regulation of human, mouse, rat MAX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAX (see all 22):
    hsa-miR-19b-2* hsa-miR-137 hsa-miR-218-2* hsa-miR-624* hsa-miR-138-2* hsa-miR-888* hsa-miR-10b* hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidMAX 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAX
    Predesigned siRNA for gene silencing in human, mouse, rat MAX

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAX

    Clone
    Products:
         
    OriGene clones in human, mouse for MAX (see all 35)
    OriGene ORF clones in mouse, rat for MAX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): MAX (NM_197957)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAX

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MAX
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAX 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAX_HUMAN, P61244: Nucleus. Cell projection, dendrite (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016605PML body IEA--
    GO:0030425dendrite IEA--

    Find genes that share ontologies with MAX           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAX About   (see all 20)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2CDK-mediated phosphorylation and removal of Cdc6
    Cyclin E associated events during G1/S transition0.86
    S Phase0.78
    Cyclin A-Cdk2-associated events at S phase entry0.85
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    4E2F mediated regulation of DNA replication
    G1/S Transition0.81
    Mitotic G1-G1/S phases0.81
    5ERK Signaling
    ERK Signaling0.61
    Molecular Mechanisms of Cancer0.51


    Find genes that share SuperPaths with MAX           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for MAX
        Adipocytokines & Insulin Signaling
    TGF-beta Signaling Pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAX
        ERK Signaling
    Molecular Mechanisms of Cancer
    p38 Signaling

    1 Cell Signaling Technology (CST) Pathway for MAX
        Apoptosis and Autophagy

    Selected BioSystems Pathways for MAX (see all 9)
        MAPK signaling pathway
    p38 MAPK Signaling Pathway
    Integrated Breast Cancer Pathway
    Regulation of nuclear SMAD2/3 signaling
    Signaling events mediated by HDAC Class I


    2 Reactome Pathways for MAX
        Cyclin A:Cdk2-associated events at S phase entry
    Cyclin E associated events during G1/S transition


    4 Kegg Pathways  (Kegg details for MAX):
        MAPK signaling pathway
    Pathways in cancer
    Transcriptional misregulation in cancer
    Small cell lung cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAX: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Transcription Factors in human mouse rat
              Prostate Cancer in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAX (P612441, 2, 3 ENSP000003514904) via UniProtKB, MINT, STRING, and/or I2D (see all 305)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS8425218
    GO:0006461protein complex assembly IEA--
    GO:0009267cellular response to starvation IEA--
    GO:0010243response to organonitrogen compound ----

    Find genes that share ontologies with MAX           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAX

    3 Novoseek inferred chemical compound relationships for MAX gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 72.4 22 7577944 (3), 1408152 (2), 15121849 (2), 8423990 (2) (see all 15)
    lysine 13.1 1 17217336 (1)
    forskolin 6.59 1 9886493 (1)



    Find genes that share compounds with MAX           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAX gene (8 alternative transcripts): 
    NM_001271068.1  NM_001271069.1  NM_002382.4  NM_145112.2  NM_145113.2  NM_145114.2  NM_197957.3  NM_145116.1  

    Unigene Cluster for MAX:

    MYC associated factor X
    Hs.285354  [show with all ESTs]
    Unigene Representative Sequence: BC036092
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341653 ENST00000358402 ENST00000394606(uc001xie.1 uc001xif.1 uc001xig.1 uc001xih.1)
    ENST00000555932 ENST00000284165(uc001xij.1) ENST00000358664 ENST00000555419
    ENST00000553928 ENST00000557277 ENST00000556892 ENST00000553951 ENST00000556979(uc001xic.1)
    ENST00000555667(uc001xii.1) ENST00000557746 ENST00000556443 ENST00000246163(uc001xik.3)
    ENST00000556702 ENST00000554709
    miRNA
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    Block miRNA regulation of human, mouse, rat MAX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAX (see all 22):
    hsa-miR-19b-2* hsa-miR-137 hsa-miR-218-2* hsa-miR-624* hsa-miR-138-2* hsa-miR-888* hsa-miR-10b* hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidMAX 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MAX
    Predesigned siRNA for gene silencing in human, mouse, rat MAX
    Clone
    Products:
         
    OriGene clones in human, mouse for MAX (see all 35)
    OriGene ORF clones in mouse, rat for MAX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): MAX (NM_197957)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAX
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MAX
    OriGene qSTAR qPCR primer pairs in human, mouse for MAX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAX
      QuantiTect SYBR Green Assays in human, mouse, rat MAX
      QuantiFast Probe-based Assays in human, mouse, rat MAX

    Additional mRNA sequence: 

    AK290130.1 AK290929.1 AK292189.1 AK292630.1 AK303412.1 AL833643.1 AY353088.1 BC003525.1 
    BC004516.2 BC013669.1 BC025685.1 BC027924.1 BC036092.1 CR542191.1 M64240.1 NR_073137.1 
    NR_073138.1 X60287.1 

    Selected DOTS entries (see all 27):

    DT.95378414  DT.100037470  DT.100817243  DT.95122128  DT.100817250  DT.98131674  DT.100809293  DT.406416 
    DT.97853570  DT.120751852  DT.100758256  DT.70103755  DT.95263923  DT.91766090  DT.100817246  DT.120751700 
    DT.100802547  DT.120751516  DT.120751826  DT.95371931  DT.100037465  DT.100721347  DT.100817237  DT.120751794 

    Selected AceView cDNA sequences (see all 306):

    AI141211 CA439543 BQ422195 BM785168 NM_145116 BG389618 CR619150 BM989983 
    H14126 AW614081 CA422649 NM_145112 BF002710 T16249 AW006411 F05304 
    AI804933 AW242767 AI571377 BM714640 BQ067185 BF196519 BF941314 NM_145113 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MAX    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:                    -           -           -                     
    SP2:                    -           -                                 
    SP3:                    -           -     -     -                     
    SP4:                    -                                             
    SP5:                                                                  


    ECgene alternative splicing isoforms for MAX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MAX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATAAAAA
    MAX Expression
    About this image


    MAX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    MAX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.285354

    UniProtKB/Swiss-Prot: MAX_HUMAN, P61244
    Tissue specificity: High levels found in the brain, heart and lung while lower levels are seen in the liver,
    kidney and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAX: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MAX gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Max1 , 5 Max protein1, 5 96.04(n)1
    99.37(a)1
      12 (33.78 cM)5
    171871  NM_008558.21  NP_032584.21 
     769372695 
    chicken
    (Gallus gallus)
    Aves MAX1 MYC associated factor X 84.17(n)
    94.96(a)
      100858676  XM_003643508.2  XP_003643556.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia max-A2 MAX protein 84.37(n)    L04924.1 
    zebrafish
    (Danio rerio)
    Actinopterygii max2 myc-associated factor X 84.03(n)   30467  BC044453.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Max6
    Max
    44(a)
    1 ↔ 1
    3L(19255626-19257284)
    worm
    (Caenorhabditis elegans)
    Secernentea mxl-16
    mxl-36
    Protein MXL-3 (mxl-3) mRNA, complete cds
    35(a)
    23(a)
    many → 1
    many → 1
    V(11244839-11245928) WBGene00003509
    X(13349640-13350804) WBGene00003511


    ENSEMBL Gene Tree for MAX (if available)
    TreeFam Gene Tree for MAX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAX gene
    11 SIMAP similar genes for MAX using alignment to 10 protein entries:     MAX_HUMAN (see all proteins):
    SREBF1    MYCLP1    N-myc    MYC    USF1    MLX
    TFAP4    MXD1    SREBF2    USF2    KIAA2018

    Find genes that share paralogs with MAX           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MAX
    PGOHUM00000233579


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAX (see all 1867)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1489691871,2
    --46455890(+) CGGTCC/TTGCCC 2 -- ds50010--------
    rs786436861,2
    C,F--46456007(+) GCCTCC/TGCAGT 2 -- ds50011Minor allele frequency- T:0.03EA 120
    rs1129218421,2
    C,F--46456036(+) ACATCA/TCTATG 2 -- ds50012Minor allele frequency- T:0.18CSA WA 119
    rs1135239731,2
    C,F--46456156(+) GATTAC/TAGCTG 2 -- ds50012Minor allele frequency- T:0.04CSA WA 119
    rs757801231,2
    C,F--46456190(+) GAACAC/TTTTTC 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1910562341,2
    --46456287(+) CCTTCA/GTCATG 2 -- ds50010--------
    rs747811781,2
    C--46456425(+) TTTTTG/TCCACC 2 -- ut310--------
    rs2010521121,2
    C--46456540(+) CCTGGG/TGAAGG 2 -- int11Minor allele frequency- T:0.00EU 1253
    rs1835678271,2
    C--46456558(+) GAAAAA/GTATCA 2 -- int10--------
    rs1878626451,2
    --46456714(+) GAGAAC/GGAGCT 2 -- int10--------

    HapMap Linkage Disequilibrium report for MAX (65472892 - 65569413 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MAX:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748787CNV Deletion23290073
    esv2748789CNV Deletion23290073
    esv2673460CNV Deletion23128226
    esv2748788CNV Deletion23290073
    esv2506970CNV Deletion19546169
    esv2748779CNV Deletion23290073
    esv2665422CNV Deletion23128226
    nsv832816CNV Gain17160897

    Human Gene Mutation Database (HGMD): MAX
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAX
    DNA2.0 Custom Variant and Variant Library Synthesis for MAX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 154950   
    OMIM disorders: 171300  
    6 diseases for MAX:    
    About MalaCards
    max-related susceptibility to pheochromocytoma    max-related hereditary paraganglioma-pheochromocytoma syndrome    pheochromocytoma    hereditary paraganglioma-pheochromocytoma syndromes
    paragangliomas 5    paraganglioma


    Find genes that share disorders with MAX           About GenesLikeMe

    4 Novoseek inferred disease relationships for MAX gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 26.8 1 7731722 (1)
    pheochromocytoma 11.8 3 7791753 (2)
    tumors 8.83 10 9018122 (4), 16908182 (1), 7791753 (1), 10229497 (1)
    cancer 0 1 18493233 (1)

    Genetic Association Database (GAD): MAX
    Human Genome Epidemiology (HuGE) Navigator: MAX (129 documents)
    Tumor Gene Database (TGDB): MAX

    Export disorders for MAX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAX gene, integrated from 10 sources (see all 196):
    (articles sorted by number of sources associating them with MAX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Max is acetylated by p300 at several nuclear localization residues. (PubMed id 17217336)1, 2, 9 Faiola F.... Martinez E. (Biochem. J. 2007)
    2. Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. (PubMed id 2006410)1, 2, 9 Blackwood E.M. and Eisenman R.N. (Science 1991)
    3. The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control. (PubMed id 9115440)1, 2, 9 Brownlie P....Suck D. (Structure 1997)
    4. Genome-wide association study of anthropometric traits in Korcula Island, Croatia. (PubMed id 19260139)1, 4 Polasek O....Rudan I. (Croat. Med. J. 2009)
    5. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PubMed id 19862010)1, 4 Ganesh S.K....Lin J.P. (Nat. Genet. 2009)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    8. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (Cell 2005)
    9. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4149 HGNC: 6913 AceView: MAX Ensembl:ENSG00000125952 euGenes: HUgn4149
    ECgene: MAX Kegg: 4149 H-InvDB: MAX

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAX Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAX Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAX gene:
    Search GeneIP for patents involving MAX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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