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Aliases for MAX Gene

Aliases for MAX Gene

  • MYC Associated Factor X 2 3 5
  • Class D Basic Helix-Loop-Helix Protein 4 3 4
  • BHLHd4 3 4
  • Myc-Associated Factor X 4
  • MAX Protein 2
  • Protein Max 3

External Ids for MAX Gene

Previous GeneCards Identifiers for MAX Gene

  • GC14M062799
  • GC14M059335
  • GC14M063462
  • GC14M063531
  • GC14M064542
  • GC14M065472
  • GC14M045642

Summaries for MAX Gene

Entrez Gene Summary for MAX Gene

  • The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for MAX Gene

MAX (MYC Associated Factor X) is a Protein Coding gene. Diseases associated with MAX include Pheochromocytoma and Hereditary Paraganglioma-Pheochromocytoma Syndromes. Among its related pathways are Pathways in cancer and p38 MAPK Signaling Pathway (WikiPathways). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for MAX Gene

  • Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5-CAC[GA]TG-3. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 Lys-9 histone methyltransferase activity.

Gene Wiki entry for MAX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAX Gene

Genomics for MAX Gene

Regulatory Elements for MAX Gene

Enhancers for MAX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MAX on UCSC Golden Path with GeneCards custom track

Promoters for MAX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MAX Gene

Chromosome:
14
Start:
65,006,101 bp from pter
End:
65,102,695 bp from pter
Size:
96,595 bases
Orientation:
Minus strand

Genomic View for MAX Gene

Genes around MAX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAX Gene

Proteins for MAX Gene

  • Protein details for MAX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61244-MAX_HUMAN
    Recommended name:
    Protein max
    Protein Accession:
    P61244
    Secondary Accessions:
    • A6NH73
    • A8K265
    • A8K4G4
    • A8K824
    • P25912
    • P52163
    • Q14803
    • Q96CY8

    Protein attributes for MAX Gene

    Size:
    160 amino acids
    Molecular mass:
    18275 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MYC or MAD. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with SPAG9. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity.

    Three dimensional structures from OCA and Proteopedia for MAX Gene

    Alternative splice isoforms for MAX Gene

neXtProt entry for MAX Gene

Post-translational modifications for MAX Gene

  • Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max complexes.
  • Ubiquitination at Lys 66
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAX (MAX)
  • Abcam antibodies for MAX

No data available for DME Specific Peptides for MAX Gene

Domains & Families for MAX Gene

Gene Families for MAX Gene

Protein Domains for MAX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAX Gene

Graphical View of Domain Structure for InterPro Entry

P61244

UniProtKB/Swiss-Prot:

MAX_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Belongs to the MAX family.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Family:
  • Belongs to the MAX family.
genes like me logo Genes that share domains with MAX: view

Function for MAX Gene

Molecular function for MAX Gene

GENATLAS Biochemistry:
Max protein,heterodimerizing with MYC,with high affinity for the DNA-binding site of MYC,binds to MAD and MNT
UniProtKB/Swiss-Prot Function:
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5-CAC[GA]TG-3. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 Lys-9 histone methyltransferase activity.

Gene Ontology (GO) - Molecular Function for MAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 2006410
GO:0003712 transcription cofactor activity TAS 8425218
GO:0003713 transcription coactivator activity TAS 2006410
genes like me logo Genes that share ontologies with MAX: view
genes like me logo Genes that share phenotypes with MAX: view

Human Phenotype Ontology for MAX Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MAX Gene

MGI Knock Outs for MAX:

Animal Model Products

CRISPR Products

Transcription Factor Targets for MAX Gene

Selected GeneGlobe predicted Target genes for MAX
Targeted motifs for MAX Gene
HOMER Transcription Factor Regulatory Elements motif MAX
  • Consensus sequence: ACCACGTGGTCN Submotif: canonical Cell Type: K562 GEO ID: GSE31477

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) for MAX Gene

Localization for MAX Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAX Gene

Nucleus. Cell projection, dendrite.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAX Gene COMPARTMENTS Subcellular localization image for MAX gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for MAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15358760
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0016605 PML body IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with MAX: view

Pathways & Interactions for MAX Gene

genes like me logo Genes that share pathways with MAX: view

SIGNOR curated interactions for MAX Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 8425218
GO:0006461 protein complex assembly IEA --
GO:0009267 cellular response to starvation IEA --
genes like me logo Genes that share ontologies with MAX: view

Drugs & Compounds for MAX Gene

(4) Drugs for MAX Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
10058-F4 Pharma C-Myc-Max dimerization inhibitor 0

(1) ApexBio Compounds for MAX Gene

Compound Action Cas Number
10058-F4 C-Myc-Max dimerization inhibitor 403811-55-2
genes like me logo Genes that share compounds with MAX: view

Transcripts for MAX Gene

Unigene Clusters for MAX Gene

MYC associated factor X:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAX Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - -
SP2: - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for MAX Gene

GeneLoc Exon Structure for
MAX
ECgene alternative splicing isoforms for
MAX

Expression for MAX Gene

mRNA expression in normal human tissues for MAX Gene

Protein differential expression in normal tissues from HIPED for MAX Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.0), CD4 Tcells (13.0), and Monocytes (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAX Gene



Protein tissue co-expression partners for MAX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAX Gene:

MAX

SOURCE GeneReport for Unigene cluster for MAX Gene:

Hs.285354

mRNA Expression by UniProt/SwissProt for MAX Gene:

P61244-MAX_HUMAN
Tissue specificity: High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
genes like me logo Genes that share expression patterns with MAX: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MAX Gene

Orthologs for MAX Gene

This gene was present in the common ancestor of animals.

Orthologs for MAX Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAX 34
  • 98.12 (n)
  • 99.37 (a)
MAX 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAX 34
  • 98.33 (n)
  • 100 (a)
MAX 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Max 34
  • 96.04 (n)
  • 99.37 (a)
Max 16
Max 35
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAX 34
  • 100 (n)
  • 100 (a)
MAX 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Max 34
  • 95.83 (n)
  • 98.75 (a)
oppossum
(Monodelphis domestica)
Mammalia MAX 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAX 35
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAX 34
  • 84.17 (n)
  • 94.96 (a)
MAX 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia max 34
  • 81.36 (n)
  • 93.7 (a)
Str.4058 34
African clawed frog
(Xenopus laevis)
Amphibia max-A 34
zebrafish
(Danio rerio)
Actinopterygii max 34
  • 79.58 (n)
  • 85 (a)
max 35
  • 82 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11119 34
fruit fly
(Drosophila melanogaster)
Insecta Max 35
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mxl-1 35
  • 35 (a)
OneToMany
mxl-3 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2903 35
  • 57 (a)
OneToOne
Species where no ortholog for MAX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAX Gene

ENSEMBL:
Gene Tree for MAX (if available)
TreeFam:
Gene Tree for MAX (if available)

Paralogs for MAX Gene

Pseudogenes.org Pseudogenes for MAX Gene

genes like me logo Genes that share paralogs with MAX: view

No data available for Paralogs for MAX Gene

Variants for MAX Gene

Sequence variations from dbSNP and Humsavar for MAX Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2411996 -- 65,101,279(-) GATAG(A/G/T)GGATC intron-variant
rs7143495 -- 65,079,643(+) TCTGT(A/G)TTACA intron-variant
rs7144259 -- 65,070,841(+) GCACC(A/T)GGCAC intron-variant
rs7145112 -- 65,067,366(+) actaa(A/C)gaaag intron-variant
rs2763887 -- 65,095,030(-) GGATT(A/C)ATGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAX Gene

Variant ID Type Subtype PubMed ID
esv2506970 CNV deletion 19546169
esv2665422 CNV deletion 23128226
esv2673460 CNV deletion 23128226
esv2748779 CNV deletion 23290073
esv2748787 CNV deletion 23290073
esv2748788 CNV deletion 23290073
esv2748789 CNV deletion 23290073
esv3551663 CNV deletion 23714750
esv3634761 CNV loss 21293372
esv3634762 CNV loss 21293372
nsv1070225 CNV deletion 25765185
nsv1108903 CNV deletion 24896259
nsv832816 CNV gain 17160897
nsv952855 CNV deletion 24416366

Variation tolerance for MAX Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAX Gene

Human Gene Mutation Database (HGMD)
MAX
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAX Gene

Disorders for MAX Gene

MalaCards: The human disease database

(7) MalaCards diseases for MAX Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search MAX in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAX

Genetic Association Database (GAD)
MAX
Human Genome Epidemiology (HuGE) Navigator
MAX
Tumor Gene Database (TGDB):
MAX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAX
genes like me logo Genes that share disorders with MAX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAX Gene

Publications for MAX Gene

  1. Max is acetylated by p300 at several nuclear localization residues. (PMID: 17217336) Faiola F. … Martinez E. (Biochem. J. 2007) 3 4 22 65
  2. The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control. (PMID: 9115440) Brownlie P. … Suck D. (Structure 1997) 3 4 22 65
  3. Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. (PMID: 2006410) Blackwood E.M. … Eisenman R.N. (Science 1991) 3 4 22 65
  4. Small-molecule perturbation of competing interactions between c-Myc and Max. (PMID: 19114306) Follis A.V. … Metallo S.J. (Bioorg. Med. Chem. Lett. 2009) 3 22 65
  5. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PMID: 19862010) Ganesh S.K. … Lin J.P. (Nat. Genet. 2009) 3 46 65

Products for MAX Gene

Sources for MAX Gene

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