Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAVS Gene

protein-coding   GIFtS: 63
GCID: GC20P003827

Mitochondrial Antiviral Signaling Protein

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mitochondrial Antiviral Signaling Protein1 2     Virus-Induced-Signaling Adapter2 3
IPS12 3 5     IPS-12 3
VISA2 3 5     CARD Adapter Inducing Interferon Beta2 3
CARD Adaptor Inducing IFN-Beta1 2     CARDIF2 5
IFN-B Promoter Stimulator 11 2     KIAA12713 5
Virus-Induced Signaling Adaptor1 2     Mitochondrial Antiviral-Signaling Protein2
Interferon Beta Promoter Stimulator Protein 12 3     Cardif3
Putative NF-Kappa-B-Activating Protein 031N2 3     

External Ids:    HGNC: 292331   Entrez Gene: 575062   Ensembl: ENSG000000888887   OMIM: 6096765   UniProtKB: Q7Z4343   
ORGUL members:         
NONCODE14:n410672      

Export aliases for MAVS gene to outside databases

Previous GC identifers: GC20P003783 GC20P003784


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAVS Gene:
This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It
is required for activation of transcription factors which regulate expression of beta interferon and contributes
to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Sep 2011)

GeneCards Summary for MAVS Gene: 
MAVS (mitochondrial antiviral signaling protein) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with MAVS include chikungunya, and rubella, and among its related super-pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Influenza A. GO annotations related to this gene include protein kinase binding and CARD domain binding.

UniProtKB/Swiss-Prot: MAVS_HUMAN, Q7Z434
Function: Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which
detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of
NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES
(CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral
infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide
short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with
delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following
detection of extracellular dsRNA by TLR3. May protect cells from apoptosis

Gene Wiki entry for MAVS (VISA) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAVS gene promoter:
         c-Fos   RFX1   AP-1   JunB   FosB   Fra-1   JunD   FOXJ2 (long isoform)   FOXJ2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAVS promoter sequence
   Search SABiosciences Chromatin IP Primers for MAVS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAVS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

MAVS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAVS gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P003827:  view genomic region     (about GC identifiers)

Start:
3,827,446 bp from pter      End:
3,856,770 bp from pter
Size:
29,325 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MAVS_HUMAN, Q7Z434 (See protein sequence)
Recommended Name: Mitochondrial antiviral-signaling protein  
Size: 540 amino acids; 56528 Da
Subunit: Interacts with DDX58/RIG-I, IFIH1/MDA5, TRAF2, TRAF6 and C1QBP. May interact with IRF3, FADD, RIPK1, CHUK
and IKBKB. Interacts with and is cleaved by HCV and hepatitis GB virus B NS3/4A proteases. Interacts with and is
cleaved by HHAV protein 3ABC. Interacts with NLRX1. Interaction with NLRX1 requires the CARD domain. Interacts
with PSMA7. Interacts with TRAFD1 (By similarity). Interacts (via C-terminus) with PCBP2 in a complex containing
MAVS/IPS1, PCBP2 and ITCH. Interacts with CYLD. Interacts with SRC. Interacts with DHX58/LGP2 and IKBKE.
Interacts with TMEM173/MITA. Interacts with IFIT3 (via N-terminus). Interacts with TBK1 only in the presence of
IFIT3. Interacts with human respiratory syncytial virus (HRSV) NS1 protein; this interaction disrupts MAVS
binding to DDX58/RIG-I
Subcellular location: Mitochondrion outer membrane. Mitochondrion. Peroxisome
Miscellaneous: Cleavage by HCV protease complex leads to inactivation
Sequence caution: Sequence=BAA86585.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB14684.1; Type=Frameshift; Positions=333;
1 PDB 3D structure from and Proteopedia for MAVS:
2VGQ (3D)    
Secondary accessions: A8K6X0 F5H6C8 Q2HWT5 Q3I0Y2 Q5T7I6 Q86VY7 Q9H1H3 Q9H4Y1 Q9H8D3 Q9ULE9
Alternative splicing: 4 isoforms:  Q7Z434-1   Q7Z434-2   Q7Z434-3   Q7Z434-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAVS: NX_Q7Z434

Explore proteomics data for MAVS at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination catalyzed by ITCH; ITCH-dependent polyubiquitination
    is mediated by the interaction with PCBP2 and leads to MAVS/IPS1 proteasomal degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z434

  • MAVS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAVS Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001193420.1  NP_065797.2  

    ENSEMBL proteins: 
     ENSP00000401980   ENSP00000350852   ENSP00000413749  
    Reactome Protein details: Q7Z434
    Human Recombinant Protein Products for MAVS: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MAVS
    OriGene Protein Over-expression Lysate for MAVS
    OriGene MassSpec for MAVS 
    OriGene Custom Protein Services for MAVS
    GenScript Custom Purified and Recombinant Proteins Services for MAVS
    Novus Biologicals MAVS Proteins
    Novus Biologicals MAVS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for MAVS
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005741mitochondrial outer membrane TAS--
    GO:0005777peroxisome ----
    GO:0005778peroxisomal membrane IDA--
    GO:0016021integral to membrane IEA--

    MAVS for ontologies           About GeneDecksing



    MAVS Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAVS
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for MAVS 
    OriGene Antibodies for MAVS
    OriGene Custom Antibody Services for MAVS
    GenScript Custom Superior Antibodies Services for MAVS
    Novus Biologicals MAVS Antibodies
    Abcam antibodies for MAVS
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for MAVS
    LSBio Antibodies in human, mouse, rat for MAVS 

    Assay Products for MAVS: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAVS
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAVS
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026148 Mt_antiviral_sig_pro

    Graphical View of Domain Structure for InterPro Entry Q7Z434

    ProtoNet protein and cluster: Q7Z434

    UniProtKB/Swiss-Prot: MAVS_HUMAN, Q7Z434
    Domain: Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible
    for interaction with DDX58/RIG-I and IFIH1/MDA5
    Domain: The transmembrane domain and residues 300-444 are essential for its interaction with DHX58/LGP2
    Similarity: Contains 1 CARD domain


    MAVS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAVS_HUMAN, Q7Z434
    Function: Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which
    detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of
    NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES
    (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral
    infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide
    short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with
    delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following
    detection of extracellular dsRNA by TLR3. May protect cells from apoptosis

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding IPI16127453
    GO:0019901protein kinase binding IPI16127453
    GO:0050700CARD domain binding IPI16127453
         
    MAVS for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Mavs):
     cardiovascular system  cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  muscle  nervous system 
     respiratory system 

    MAVS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MAVS: Mavstm1Camb Mavstm1Aki Mavstm1Itl Mavstm1Tsc Mavstm1Zjc

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAVS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAVS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAVS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAVS 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAVS
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate MAVS (see all 29):
    hsa-miR-3678-3p hsa-miR-125a-5p hsa-miR-300 hsa-miR-4328 hsa-miR-330-5p hsa-miR-125a-3p hsa-miR-539 hsa-miR-488
    SwitchGear 3'UTR luciferase reporter plasmidMAVS 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAVS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAVS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAVS
    Sirion Biotech Customized adenovirus for overexpression of MAVS

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MAVS (see all 6)
    OriGene ORF clones in mouse, rat for MAVS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MAVS (NM_020746)
    Sino Biological Human cDNA Clone for MAVS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAVS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAVS
    Sirion Biotech Customized lentivirus for stable overexpression of MAVS 
                         Customized lentivirus expression plasmids for stable overexpression of MAVS 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAVS
    Search LifeMap BioReagents cell lines for MAVS
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAVS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAVS About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.52
    Negative regulators of RIG-I/MDA5 signaling0.49
    RIG-I-like receptor signaling pathway0.52
    2Influenza A
    Influenza A0.34
    Herpes simplex infection0.33
    Measles0.34
    3Immune System
    Immune System0.56
    Innate Immune System0.50
    4TRAF6 mediated IRF7 activation
    TRAF6 mediated IRF7 activation0.45
    TRAF3-dependent IRF activation pathway0.45
    5RIP-mediated NFkB activation via ZBP1
    TRAF6 mediated NF-kB activation0.42
    NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -100.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MAVS
        NF-kappaB Signaling


    5/8        Reactome Pathways for MAVS (see all 8)
        NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    TRAF3-dependent IRF activation pathway
    TRAF6 mediated IRF7 activation
    TRAF6 mediated NF-kB activation


    5/7         Kegg Pathways  (Kegg details for MAVS) (see all 7):
        RIG-I-like receptor signaling pathway
    Cytosolic DNA-sensing pathway
    Hepatitis C
    Hepatitis B
    Measles


    MAVS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAVS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/93 Interacting proteins for MAVS (Q7Z4341, 2, 3 ENSP000004019804) via UniProtKB, MINT, STRING, and/or I2D (see all 93)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-7297542 MINT-7297557 MINT-7297574 MINT-7297526 MINT-7297498 MINT-7297511 I2D: score=2 STRING: ENSP00000361423
    ENSG00000096155P463791, 3EBI-995373,EBI-347552 I2D: score=1 
    ENSG00000227761P463791, 3EBI-995373,EBI-347552 I2D: score=1 
    ENSG00000228760P463791, 3EBI-995373,EBI-347552 I2D: score=1 
    ENSG00000229524P463791, 3EBI-995373,EBI-347552 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation IDA16127453
    GO:0002218activation of innate immune response IMP18818105
    GO:0002230positive regulation of defense response to virus by host IMP19609254
    GO:0007165signal transduction IMP--
    GO:0019048modulation by virus of host morphology or physiology IEA--

    MAVS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAVS

    Search CenterWatch for drugs/clinical trials and news about MAVS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAVS gene (2 alternative transcripts): 
    NM_001206491.1  NM_020746.4  

    Unigene Cluster for MAVS:

    Mitochondrial antiviral signaling protein
    Hs.570362  [show with all ESTs]
    Unigene Representative Sequence: NM_020746
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000428216(uc002wjv.3 uc002wjx.4 uc002wjw.4 uc002wjy.4)
    ENST00000358134 ENST00000416600
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAVS
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate MAVS (see all 29):
    hsa-miR-3678-3p hsa-miR-125a-5p hsa-miR-300 hsa-miR-4328 hsa-miR-330-5p hsa-miR-125a-3p hsa-miR-539 hsa-miR-488
    SwitchGear 3'UTR luciferase reporter plasmidMAVS 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAVS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAVS
    Clone
    Products:
         
    OriGene clones in human, mouse for MAVS (see all 6)
    OriGene ORF clones in mouse, rat for MAVS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MAVS (NM_020746)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAVS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAVS
    Sirion Biotech Customized lentivirus for stable overexpression of MAVS 
                         Customized lentivirus expression plasmids for stable overexpression of MAVS 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MAVS
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAVS
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAVS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAVS

    Additional mRNA sequence: 

    AB033097.1 AB097003.1 AB232371.1 AK023799.1 AK056260.1 AK092705.1 AK095370.1 AK123956.1 
    AK130992.1 AK291785.1 AK296897.1 AL390136.1 BC000073.2 BC028962.1 BC040719.1 BC040930.1 
    BC044952.1 BC052583.1 BC062310.1 BC063593.1 BX649084.1 DQ167126.1 DQ174270.1 DQ181928.1 
    EF467323.1 EF467324.1 NR_037921.1 

    17 DOTS entries:

    DT.406159  DT.40199115  DT.121644534  DT.101980187  DT.100778842  DT.120824788  DT.99932965  DT.86846786 
    DT.92420181  DT.97823592  DT.100778843  DT.111458  DT.100778841  DT.75101330  DT.92032322  DT.92422048 
    DT.92013360 

    24/331 AceView cDNA sequences (see all 331):

    BQ774259 CB055222 BM800224 BU188769 AL135056 T07608 AI123632 BC052583 
    AA442990 AA633373 AA421036 AU140492 AI743334 BM709876 CA413168 CR613265 
    AI092229 AI082332 AA558474 AI884661 AW298312 BU185620 AI653175 AW298314 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MAVS (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
    SP1:        -                       -                                             
    SP2:        -           -           -                                             
    SP3:                    -           -                                             
    SP4:        -           -     -     -                                             
    SP5:        -           -     -     -     -                                       


    ECgene alternative splicing isoforms for MAVS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAVS expression in normal human tissues (normalized intensities)      MAVS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGGCAGAG
    MAVS Expression
    About this image


    MAVS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   

    See MAVS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAVS

    SOURCE GeneReport for Unigene cluster: Hs.570362

    UniProtKB/Swiss-Prot: MAVS_HUMAN, Q7Z434
    Tissue specificity: Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level).
    Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood
    leukocytes

        SABiosciences Expression via Pathway-Focused PCR Array including MAVS: 
              Antiviral Response in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MAVS
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAVS
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAVS
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAVS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAVS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MAVS gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mavs1 , 5 mitochondrial antiviral signaling protein1, 5 68.75(n)1
    55.13(a)1
      2 (63.30 cM)5
    2286071  NM_144888.21  NP_659137.11 
     1312340635 
    chicken
    (Gallus gallus)
    Aves MAVS6
    mitochondrial antiviral signaling protein
    19(a)
    1 ↔ 1
    4(88059162-88064033)
    zebrafish
    (Danio rerio)
    Actinopterygii mavs6
    mitochondrial antiviral signaling protein
    15(a)
    1 ↔ 1
    13(15136148-15167556)


    ENSEMBL Gene Tree for MAVS (if available)
    TreeFam Gene Tree for MAVS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/874 SNPs in MAVS are shown (see all 874)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1116234231,2
    C--3768672(+) CAAAC-/AAAAAA 3 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs735723491,2
    C--3768699(+) GTCACC/TGAGTA 3 -- us2k12Minor allele frequency- T:0.21WA 120
    rs1476546301,2
    C--3768768(+) TGGCTC/TACGCC 3 -- us2k10--------
    rs790614581,2
    C--3768770(+) GCTCAC/TGCCTG 3 -- us2k10--------
    rs1423086901,2
    --3768861(+) AACCTC/TGTCTC 3 -- us2k10--------
    rs778646131,2
    C,F--3769072(+) GGCTCG/ATGGGT 3 -- us2k15Minor allele frequency- A:0.08WA CSA NA 244
    rs1512831601,2
    --3769198(+) CTGTTG/TCCCTA 3 -- us2k10--------
    rs60844921,2
    C,H--3769216(+) tttcaG/Aatcat 3 -- us2k16Minor allele frequency- A:0.00NS EA NA 402
    rs1405392281,2
    --3769226(+) TGAGCC/TTTTGA 3 -- us2k10--------
    rs1155726631,2
    C,F--3769232(+) TTTGAT/CAGGAA 3 -- us2k12Minor allele frequency- C:0.05WA NA 238

    HapMap Linkage Disequilibrium report for MAVS (3827446 - 3856770 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MAVS:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv521026CNV Loss19592680
    nsv522507CNV Loss19592680
    nsv912622CNV Loss21882294
    nsv527710CNV Loss19592680
    nsv833899CNV Loss17160897
    nsv520430CNV Loss19592680
    nsv828673CNV Gain20364138


    Human Gene Mutation Database (HGMD): MAVS
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MAVS
    DNA2.0 Custom Variant and Variant Library Synthesis for MAVS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609676    OMIM disorders: --

    15 diseases for MAVS:    About MalaCards
    chikungunya    rubella    cytomegalovirus infection    vaccinia
    hepatitis c    measles    influenza    hepatitis
    hepatitis b    pneumonia    systemic lupus erythematosus    asthma
    lupus erythematosus    gastric cancer    endotheliitis


    MAVS for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for MAVS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 60.1 3 16125763 (1), 16585524 (1), 20044805 (1)
    melanoma 42.9 1 19669308 (1)
    hepatitis c 29.6 3 16585524 (1), 17517627 (1)

    Genetic Association Database (GAD): MAVS
    Human Genome Epidemiology (HuGE) Navigator: MAVS (4 documents)

    Export disorders for MAVS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAVS gene, integrated from 9 sources (see all 148):
    (articles sorted by number of sources associating them with MAVS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. (PubMed id 16125763)1, 2, 3, 9 Seth R.B.... Chen Z.J. (2005)
    2. VISA is an adapter protein required for virus-triggered IFN-beta Signaling. (PubMed id 16153868)1, 2, 3 Xu L.-G.... Shu H.-B. (2005)
    3. Respiratory syncytial virus NS1 protein colocalizes wi th mitochondrial antiviral signaling protein MAVS following infection. (PubMed id 22383950)1, 2 Boyapalle S....Mohapatra S. (2012)
    4. IFN-induced TPR protein IFIT3 potentiates antiviral s ignaling by bridging MAVS and TBK1. (PubMed id 21813773)1, 2 Liu X.Y....Wang C. (2011)
    5. Genome-wide association study of asthma identifies RA D50-IL13 and HLA-DR/DQ regions. (PubMed id 20159242)1, 4 Li X....Bleecker E.R. (2010)
    6. Negative regulation of MAVS-mediated innate immune response by PSMA7. (PubMed id 19734229)1, 2 Jia Y.... Zhong H. (2009)
    7. PCBP2 mediates degradation of the adaptor MAVS via th e HECT ubiquitin ligase AIP4. (PubMed id 19881509)1, 2 You F....Jiang Z. (2009)
    8. The tyrosine kinase c-Src enhances RIG-I (retinoic ac id-inducible gene I)-elicited antiviral signaling. (PubMed id 19419966)1, 2 Johnsen I.B....Anthonsen M.W. (2009)
    9. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. (PubMed id 19631370)1, 2 Chiu Y.-H.... Chen Z.J. (2009)
    10. GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVS. (PubMed id 17093192)1, 2 Chen Z.... Li K. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57506 HGNC: 29233 AceView: KIAA1271 Ensembl:ENSG00000088888 euGenes: HUgn57506
    ECgene: MAVS Kegg: 57506 H-InvDB: MAVS

    (According to HUGE)
    About This Section
    HUGE: KIAA1271

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAVS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAVS gene:
    Search GeneIP for patents involving MAVS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of MAVS
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MAVS   OriGene RNAi products in human, mouse, rat for MAVS  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for MAVS  
     OriGene MassSpec something-or-other for MAVS   OriGene clones in human, mouse for MAVS  
     OriGene qSTAR qPCR primer pairs in human, mouse for MAVS   OriGene Purified Protein for MAVS  
     OriGene ORF clones in mouse, rat for MAVS   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MAVS   OriGene Custom Protein Services for MAVS  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAVS
     QIAGEN SeqTarget long-range PCR primers for resequencing MAVS
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAVS
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAVS
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAVS
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAVS
     GenScript Custom Purified and Recombinant Proteins Services for MAVS GenScript cDNA clones with any tag delivered in your preferred vector for MAVS
     GenScript Custom Assay Services for MAVS GenScript Custom Superior Antibodies Services for MAVS
     GenScript Custom overexpressing Cell Line Services for MAVS CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for MAVS 

     Regulatory tfbs in MAVS promoter
     Search Chromatin IP Primers for MAVS
     RT2 qPCR Primer Assay in human, mouse, rat MAVS
     GNC Network for MAVS
     SABiosciences PCR Arrays including human, mouse, rat MAVS
     Search Tocris compounds for MAVS
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for MAVS
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MAVS antibodies
     MAVS proteins
     MAVS lysates
     Antibodies for MAVS
     See all of Abcam's Antibodies, Kits and Proteins for MAVS
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for MAVS




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for MAVS
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAVS
     SwitchGear 3'UTR luciferase reporter plasmids for MAVS
     SwitchGear Promoter luciferase reporter plasmids for MAVS
     ThermoFisher Antibody for MAVS
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAVS
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MAVS
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAVS
    Customized:
     lentivirus for stable overexpression of MAVS
     lentivirus expression plasmids for stable overexpression of MAVS
     adenovirus for overexpression of MAVS
     LSBio Antibodies in human, mouse, rat for MAVS
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MAVS gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4