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Aliases for MAVS Gene

Aliases for MAVS Gene

  • Mitochondrial Antiviral Signaling Protein 2 3 5
  • Interferon Beta Promoter Stimulator Protein 1 3 4
  • Putative NF-Kappa-B-Activating Protein 031N 3 4
  • CARD Adapter Inducing Interferon Beta 3 4
  • Virus-Induced Signaling Adaptor 2 3
  • Virus-Induced-Signaling Adapter 3 4
  • CARD Adaptor Inducing IFN-Beta 2 3
  • IFN-B Promoter Stimulator 1 2 3
  • CARDIF 3 4
  • IPS-1 3 4
  • IPS1 3 4
  • VISA 3 4
  • KIAA1271 4

External Ids for MAVS Gene

Previous GeneCards Identifiers for MAVS Gene

  • GC20P003783
  • GC20P003784

Summaries for MAVS Gene

Entrez Gene Summary for MAVS Gene

  • This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for MAVS Gene

MAVS (Mitochondrial Antiviral Signaling Protein) is a Protein Coding gene. Diseases associated with MAVS include Viral Infectious Disease and Chikungunya. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and NF-kappaB Signaling. GO annotations related to this gene include protein kinase binding and CARD domain binding.

UniProtKB/Swiss-Prot for MAVS Gene

  • Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.

Gene Wiki entry for MAVS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAVS Gene

Genomics for MAVS Gene

Regulatory Elements for MAVS Gene

Enhancers for MAVS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAVS on UCSC Golden Path with GeneCards custom track

Promoters for MAVS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAVS on UCSC Golden Path with GeneCards custom track

Genomic Location for MAVS Gene

Chromosome:
20
Start:
3,846,799 bp from pter
End:
3,876,123 bp from pter
Size:
29,325 bases
Orientation:
Plus strand

Genomic View for MAVS Gene

Genes around MAVS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAVS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAVS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAVS Gene

Proteins for MAVS Gene

  • Protein details for MAVS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z434-MAVS_HUMAN
    Recommended name:
    Mitochondrial antiviral-signaling protein
    Protein Accession:
    Q7Z434
    Secondary Accessions:
    • A8K6X0
    • B2BD33
    • B2BD34
    • F5H6C8
    • M1P2Z0
    • Q2HWT5
    • Q3I0Y2
    • Q5T7I6
    • Q86VY7
    • Q9H1H3
    • Q9H4Y1
    • Q9H8D3
    • Q9ULE9

    Protein attributes for MAVS Gene

    Size:
    540 amino acids
    Molecular mass:
    56528 Da
    Quaternary structure:
    • Self-associates and polymerizes (via CARD domains) to form 400 nM long three-stranded helical filaments on mitochondria, filament nucleation requires interaction with DDX58/RIG-I whose CARD domains act as a template for filament assembly. Interacts with DDX58/RIG-I, IFIH1/MDA5, TRAF2, TRAF6 and C1QBP (PubMed:17600090). May interact with IRF3, FADD, RIPK1, CHUK and IKBKB. Interacts with NLRX1. Interaction with NLRX1 requires the CARD domain. Interacts with PSMA7. Interacts with TRAFD1 (By similarity). Interacts (via C-terminus) with PCBP2 in a complex containing MAVS/IPS1, PCBP2 and ITCH. Interacts with CYLD. Interacts with SRC. Interacts with DHX58/LGP2 and IKBKE. Interacts with TMEM173/MITA. Interacts with IFIT3 (via N-terminus). Interacts with TBK1 only in the presence of IFIT3. Interacts with MUL1. Interacts with ANKRD17. Interacts with and is cleaved by HCV and hepatitis GB virus B NS3/4A proteases. Interacts with and is cleaved by HHAV protein 3ABC. Interacts with human respiratory syncytial virus (HRSV) NS1 protein; this interaction disrupts MAVS binding to DDX58/RIG-I.
    Miscellaneous:
    • Cleavage by HCV protease complex leads to inactivation.
    SequenceCaution:
    • Sequence=BAA86585.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14684.1; Type=Frameshift; Positions=333; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAVS Gene

    Alternative splice isoforms for MAVS Gene

neXtProt entry for MAVS Gene

Proteomics data for MAVS Gene at MOPED

Post-translational modifications for MAVS Gene

  • Ubiquitinated; undergoes Lys-48-linked polyubiquitination catalyzed by ITCH; ITCH-dependent polyubiquitination is mediated by the interaction with PCBP2 and leads to MAVS/IPS1 proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAVS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAVS (MAVS)
  • Abcam antibodies for MAVS

No data available for DME Specific Peptides for MAVS Gene

Domains & Families for MAVS Gene

Gene Families for MAVS Gene

Protein Domains for MAVS Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7Z434

UniProtKB/Swiss-Prot:

MAVS_HUMAN :
  • Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with DDX58/RIG-I and IFIH1/MDA5.
Domain:
  • Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with DDX58/RIG-I and IFIH1/MDA5.
  • The transmembrane domain and residues 300-444 are essential for its interaction with DHX58/LGP2.
  • Contains 1 CARD domain.
genes like me logo Genes that share domains with MAVS: view

Function for MAVS Gene

Molecular function for MAVS Gene

UniProtKB/Swiss-Prot Function:
Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.

Gene Ontology (GO) - Molecular Function for MAVS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050700 CARD domain binding IPI 16127453
genes like me logo Genes that share ontologies with MAVS: view
genes like me logo Genes that share phenotypes with MAVS: view

Animal Models for MAVS Gene

MGI Knock Outs for MAVS:

Animal Model Products

CRISPR Products

miRNA for MAVS Gene

miRTarBase miRNAs that target MAVS

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAVS Gene

Localization for MAVS Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAVS Gene

Mitochondrion outer membrane. Mitochondrion. Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAVS Gene COMPARTMENTS Subcellular localization image for MAVS gene
Compartment Confidence
mitochondrion 5
peroxisome 5
cytosol 2
endoplasmic reticulum 1
endosome 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MAVS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IEA --
genes like me logo Genes that share ontologies with MAVS: view

Pathways & Interactions for MAVS Gene

genes like me logo Genes that share pathways with MAVS: view

Gene Ontology (GO) - Biological Process for MAVS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IDA 16127453
GO:0007165 signal transduction IMP 20451243
GO:0016032 viral process IEA --
GO:0032481 positive regulation of type I interferon production IEA --
GO:0032727 positive regulation of interferon-alpha production IMP 19609254
genes like me logo Genes that share ontologies with MAVS: view

No data available for SIGNOR curated interactions for MAVS Gene

Drugs & Compounds for MAVS Gene

No Compound Related Data Available

Transcripts for MAVS Gene

mRNA/cDNA for MAVS Gene

Unigene Clusters for MAVS Gene

Mitochondrial antiviral signaling protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAVS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: - - - - -
SP6: -
SP7:

Relevant External Links for MAVS Gene

GeneLoc Exon Structure for
MAVS
ECgene alternative splicing isoforms for
MAVS

Expression for MAVS Gene

mRNA expression in normal human tissues for MAVS Gene

Protein differential expression in normal tissues from HIPED for MAVS Gene

This gene is overexpressed in Nasal epithelium (12.8), Bone (10.2), and Lavage (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAVS Gene



SOURCE GeneReport for Unigene cluster for MAVS Gene Hs.570362

mRNA Expression by UniProt/SwissProt for MAVS Gene

Q7Z434-MAVS_HUMAN
Tissue specificity: Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with MAVS: view

Protein tissue co-expression partners for MAVS Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MAVS Gene

Orthologs for MAVS Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAVS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAVS 35
  • 75.07 (n)
  • 62.1 (a)
MAVS 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAVS 35
  • 72.61 (n)
  • 57.23 (a)
MAVS 36
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mavs 35
  • 69.74 (n)
  • 55.44 (a)
Mavs 16
Mavs 36
  • 52 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAVS 35
  • 99.38 (n)
  • 98.89 (a)
MAVS 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mavs 35
  • 69.94 (n)
  • 54.28 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia MAVS 36
  • 23 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAVS 36
  • 17 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mavs 36
  • 16 (a)
OneToOne
Species with no ortholog for MAVS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAVS Gene

ENSEMBL:
Gene Tree for MAVS (if available)
TreeFam:
Gene Tree for MAVS (if available)

Paralogs for MAVS Gene

No data available for Paralogs for MAVS Gene

Variants for MAVS Gene

Sequence variations from dbSNP and Humsavar for MAVS Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs7269320 - 3,865,750(+) CAGCT(C/T)TGAGA nc-transcript-variant, reference, missense
rs11905552 - 3,857,753(+) GGGCT(C/G/T)TGAGC intron-variant, nc-transcript-variant, reference, missense
rs17857295 - 3,857,794(+) TCTAC(A/C/G)AGAGC intron-variant, nc-transcript-variant, reference, missense
rs7262903 - 3,862,380(+) AGGAG(A/C/T)AGGAC nc-transcript-variant, reference, missense
rs11908032 - 3,857,752(+) GGGGC(A/T)GTGAG intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MAVS Gene

Variant ID Type Subtype PubMed ID
nsv833899 CNV Loss 17160897
nsv828673 CNV Gain 20364138
nsv912622 CNV Loss 21882294
nsv522507 CNV Loss 19592680
nsv520430 CNV Loss 19592680
nsv527710 CNV Loss 19592680
nsv521026 CNV Loss 19592680

Variation tolerance for MAVS Gene

Residual Variation Intolerance Score: 76.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.32; 97.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAVS Gene

Human Gene Mutation Database (HGMD)
MAVS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAVS Gene

Disorders for MAVS Gene

MalaCards: The human disease database

(3) MalaCards diseases for MAVS Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
viral infectious disease
  • arbovirus infectious disease
chikungunya
  • chikungunya fever
hepatitis
  • hepatitis a
- elite association - COSMIC cancer census association via MalaCards
Search MAVS in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAVS

Genetic Association Database (GAD)
MAVS
Human Genome Epidemiology (HuGE) Navigator
MAVS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAVS
genes like me logo Genes that share disorders with MAVS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAVS Gene

Publications for MAVS Gene

  1. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. (PMID: 16125763) Seth R.B. … Chen Z.J. (Cell 2005) 2 3 4 23 67
  2. Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system. (PMID: 20044805) Bellecave P. … Heim M.H. (Hepatology 2010) 3 23
  3. DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up- regulate IFN-beta-inducing potential. (PMID: 20127681) Oshiumi H. … Seya T. (Eur. J. Immunol. 2010) 3 23
  4. The RNA-activated protein kinase enhances the induction of interferon-beta and apoptosis mediated by cytoplasmic RNA sensors. (PMID: 19028691) McAllister C.S. … Samuel C.E. (J. Biol. Chem. 2009) 3 23
  5. Identification of MAVS splicing variants that interfere with RIGI/MAVS pathway signaling. (PMID: 18207245) Lad S.P. … Li E. (Mol. Immunol. 2008) 3 23

Products for MAVS Gene

Sources for MAVS Gene

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