MAVS Gene
protein-coding GIFtS: 59
GCID: GC20P003827
|
|
mitochondrial antiviral signaling protein
| |
Aliases
for MAVS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Mitochondrial Antiviral Signaling Protein1 2 | | Virus-Induced-Signaling Adapter2 3 | | VISA1 2 3 5 | | CARD Adapter Inducing Interferon Beta2 3 | | IPS-11 2 3 | | CARDIF2 5 | | KIAA12711 3 5 | | CARD Adaptor Inducing IFN-Beta2 | | IPS12 3 5 | | IFN-B Promoter Stimulator 12 | | Cardif1 3 | | Mitochondrial Antiviral-Signaling Protein2 | | Interferon Beta Promoter Stimulator Protein 12 3 | | Virus-Induced Signaling Adaptor2 | | Putative NF-Kappa-B-Activating Protein 031N2 3 | | |
| External Ids: | HGNC: 292331 | Entrez Gene: 575062 | Ensembl: ENSG000000888887 | OMIM: 6096765 | UniProtKB: Q7Z4343 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n410672 | |
Export aliases for MAVS gene to outside databasesPrevious GC identifers: GC20P003783 GC20P003784
Summaries
for MAVS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAVS:
This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It isrequired for activation of transcription factors which regulate expression of beta interferon and contributes toantiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene. (providedby RefSeq, Sep 2011)
UniProtKB/Swiss-Prot: MAVS_HUMAN, Q7Z434Function: Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, whichdetect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation ofNF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5).Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection,peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-termprotection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics,which amplifies and stabilizes the antiviral response. May activate the same pathways following detection ofextracellular dsRNA by TLR3. May protect cells from apoptosis
Gene Wiki entry for MAVS (VISA)
|
Genomic Views
for MAVS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAVS gene promoter:
c-Fos RFX1 AP-1 JunB FosB Fra-1 JunD FOXJ2 (long isoform) FOXJ2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAVS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAVS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13MAVS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P003827: view genomic region
(about GC identifiers)
Start:
|
3,827,449 bp from pter |
End:
|
3,856,762 bp from pter |
Size:
|
29,314 bases |
Orientation:
|
plus strand |
|
Proteins
for MAVS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAVS_HUMAN, Q7Z434 (See
protein sequence)Recommended Name: Mitochondrial antiviral-signaling protein Size: 540 amino acids; 56528 Da
Subunit: Interacts with DDX58/RIG-I, IFIH1/MDA5, TRAF2, TRAF6 and C1QBP. May interact with IRF3, FADD, RIPK1, CHUK andIKBKB. Interacts with and is cleaved by HCV and hepatitis GB virus B NS3/4A proteases. Interacts with and is cleavedby HHAV protein 3ABC. Interacts with NLRX1. Interaction with NLRX1 requires the CARD domain. Interacts with PSMA7.Interacts with TRAFD1 (By similarity). Interacts (via C-terminus) with PCBP2 in a complex containing MAVS/IPS1, PCBP2and ITCH. Interacts with CYLD. Interacts with SRC. Interacts with DHX58/LGP2 and IKBKE. Interacts with TMEM173/MITA.Interacts with IFIT3 (via N-terminus). Interacts with TBK1 only in the presence of IFIT3
Subcellular location: Mitochondrion outer membrane. Mitochondrion. Peroxisome
Miscellaneous: Cleavage by HCV protease complex leads to inactivation
Sequence caution: Sequence=BAA86585.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=BAB14684.1; Type=Frameshift; Positions=333;
1 PDB 3D structure from  and Proteopedia  for MAVS:2VGQ (3D)
Secondary accessions: A8K6X0 F5H6C8 Q2HWT5 Q3I0Y2 Q5T7I6 Q86VY7 Q9H1H3 Q9H4Y1 Q9H8D3 Q9ULE9Alternative splicing: 4 isoforms: Q7Z434-1 Q7Z434-2 Q7Z434-3 Q7Z434-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MAVS: NX_Q7Z434
Post-translational modifications:
Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination catalyzed by ITCH; ITCH-dependent polyubiquitination ismediated by the interaction with PCBP2 and leads to MAVS/IPS1 proteasomal degradation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z434
MAVS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001193420.1 NP_065797.2
ENSEMBL proteins: ENSP00000401980 ENSP00000350852 ENSP00000413749 Reactome Protein details: Q7Z434
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
MAVS for ontologies About GeneDecksing
MAVS Antibody Products:
Assay Products for MAVS: |
Protein
Domains /
Families
for MAVS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAVS for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q7Z434ProtoNet protein and cluster: Q7Z434 UniProtKB/Swiss-Prot: MAVS_HUMAN, Q7Z434Domain: Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible forinteraction with DDX58/RIG-I and IFIH1/MDA5Domain: The transmembrane domain and residues 300-444 are essential for its interaction with DHX58/LGP2Similarity: Contains 1 CARD domain |
Function
for MAVS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MAVS_HUMAN, Q7Z434Function: Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, whichdetect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation ofNF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5).Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection,peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-termprotection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics,which amplifies and stabilizes the antiviral response. May activate the same pathways following detection ofextracellular dsRNA by TLR3. May protect cells from apoptosis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAVS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAVS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MAVS (NM_020746) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAVS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAVS |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAVS |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
MAVS for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for MAVS: Mavstm1Camb Mavstm1Aki Mavstm1Itl Mavstm1Tsc Mavstm1Zjc
11 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Mavs):
MAVS for phenotypes About GeneDecksing
|
Pathways & Interactions
for MAVS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | | | 2 | Immune System | | | 3 | Negative regulation of RIG-I/MDA5 signaling by TRIAD3A | | | 4 | Measles | | | 5 | RIP-mediated NFkB activation via DAI | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for MAVS
5/10 
Reactome Pathways for MAVS (see all 10)
5 
Kegg Pathways (Kegg details for MAVS):
MAVS for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAVS
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/81 Interacting proteins for MAVS (Q7Z4341, 2, 3 ENSP000004019804) via UniProtKB, MINT, STRING, and/or I2D (see all 81)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| ABL1 | P005192, 3, ENSP000003614234 | MINT-7297542 MINT-7297557 MINT-7297574 MINT-7297526 MINT-7297498 MINT-7297511 I2D:
score=2 STRING: ENSP00000361423 | | MFN1 | Q8IWA42, 3, ENSP000002639694 | MINT-7714001 MINT-7713992 I2D:
score=2 STRING: ENSP00000263969 | | CYLD | Q9NQC72, 3, ENSP000003089284 | MINT-6804603 I2D:
score=2 STRING: ENSP00000308928 | | IRF5 | Q135681, 3, ENSP000003497704 | EBI-995373,EBI-3931258 I2D:
score=1 STRING: ENSP00000349770 | | STAT1 | P422241, 3, ENSP000003543944 | EBI-995373,EBI-1057697 I2D:
score=1 STRING: ENSP00000354394 |
About this table
Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25): About this table
MAVS for ontologies About GeneDecksing
|
Drugs & Compounds
for MAVS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAVS
Search CenterWatch for drugs/clinical trials and news about MAVS
|
Transcripts
for MAVS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAVS gene (2 alternative transcripts): NM_001206491.1 NM_020746.4 Unigene Cluster for MAVS: Mitochondrial antiviral signaling protein Hs.570362 [show with all ESTs]Unigene Representative Sequence: NM_0207463 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000428216(uc002wjv.3 uc002wjx.4 uc002wjw.4 uc002wjy.4)
ENST00000358134 ENST00000416600
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAVS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAVS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MAVS (NM_020746) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAVS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAVS |
Additional cDNA sequence: AB033097.1 AB097003.1 AB232371.1 AK023799.1 AK056260.1 AK092705.1 AK095370.1 AK123956.1 AK130992.1 AK291785.1 AK296897.1 AL390136.1 BC000073.2 BC028962.1 BC040719.1 BC040930.1 BC044952.1 BC052583.1 BC062310.1 BC063593.1 BX649084.1 DQ167126.1 DQ174270.1 DQ181928.1 EF467323.1 EF467324.1 NR_037921.1 17 DOTS entries: DT.406159 DT.40199115 DT.121644534 DT.101980187 DT.100778842 DT.120824788 DT.99932965 DT.86846786 DT.92420181 DT.97823592 DT.100778843 DT.111458 DT.100778841 DT.75101330 DT.92032322 DT.92422048 DT.92013360 24/331 AceView cDNA sequences (see all 331): AI123632 AI925632 BX504554 BX421695 BG390580 AI244131 BQ050901 AW298312 BM562790 AW298314 BI007397 BM789127 BU956892 CB055222 CR613265 AI092229 AA948202 AA558474 AL135056 BC052583 BM827165 BX356271 BU185620 BI334883
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MAVS (see all 7) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 |
|---|
|
| SP1: | | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | - | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MAVS
|
Expression
for MAVS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAVS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAGGCAGAG
About this image
See MAVS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAVS
SOURCE GeneReport for Unigene cluster: Hs.570362
UniProtKB/Swiss-Prot: MAVS_HUMAN, Q7Z434Tissue specificity: Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitouslyexpressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes
SABiosciences Expression via Pathway-Focused PCR Array including MAVS:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAVS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAVS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAVS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAVS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAVS |
Orthologs
for MAVS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MAVS gene from 3/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mavs1 , 5 |
mitochondrial antiviral signaling protein1, 5 |
68.75(n)1
55.13(a)1 |
|
2 (63.30 cM)5
2286071 NM_144888.21 NP_659137.11
1312340635 |
chicken
(Gallus gallus) |
Aves |
LOC4229366 |
hypothetical protein LOC422936 |
20(a) |
1 ↔ 1 |
4(91915663-91923620) |
zebrafish
(Danio rerio) |
Actinopterygii |
mavs6 |
mitochondrial antiviral signaling protein |
16(a) |
1 ↔ 1 |
13(15136148-15167556) |
ENSEMBL Gene Tree for MAVS (if available)
TreeFam Gene Tree for MAVS (if available) |
Paralogs
for MAVS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MAVS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAVS (3827449 - 3856762 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MAVS
1 CNV: 50655
Human Gene Mutation Database (HGMD): MAVS
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAVS |
|
Disorders
/ Diseases
for MAVS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAVS for disorders About GeneDecksing
OMIM gene information: 609676
OMIM disorders: --
13  diseases for MAVS: About MalaCardssystemic lupus erythematosus lupus erythematosus cytomegalovirus infection chikungunya
hepatitis c rubella hepatitis b measles
vaccinia hepatitis influenza asthma
pneumonia
3 Novoseek disease relationships for MAVS gene About this table
Human Genome Epidemiology (HuGE) Navigator: MAVS (4 documents)
Export disorders for MAVS gene to outside databases
|
Publications
for MAVS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAVS gene, integrated from 9 sources (see all 138):
(articles sorted by number of sources associating them with MAVS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. (PubMed id 16125763)1, 2, 3, 9 Seth R.B.... Chen Z.J. (2005)
- VISA is an adapter protein required for virus-triggered IFN-beta Signaling. (PubMed id 16153868)1, 2, 3 Xu L.-G.... Shu H.-B. (2005)
- IFN-induced TPR protein IFIT3 potentiates antiviral s ignaling by bridging MAVS and TBK1. (PubMed id 21813773)1, 2 Liu X.Y....Wang C. (2011)
- Negative regulation of MAVS-mediated innate immune response by PSMA7. (PubMed id 19734229)1, 2 Jia Y.... Zhong H. (2009)
- PCBP2 mediates degradation of the adaptor MAVS via th e HECT ubiquitin ligase AIP4. (PubMed id 19881509)1, 2 You F....Jiang Z. (2009)
- The tyrosine kinase c-Src enhances RIG-I (retinoic ac id-inducible gene I)-elicited antiviral signaling. (PubMed id 19419966)1, 2 Johnsen I.B....Anthonsen M.W. (2009)
- RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. (PubMed id 19631370)1, 2 Chiu Y.-H.... Chen Z.J. (2009)
- GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVS. (PubMed id 17093192)1, 2 Chen Z.... Li K. (2007)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. (PubMed id 16177806)1, 2 Meylan E.... Tschopp J. (2005)
|
External Searches for MAVS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAVS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAVS gene
(According to HUGE)
About This Section
| |
Specialized Databases showing MAVS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for MAVS | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MAVS gene:
Search GeneIP for patents involving MAVS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MAVS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for MAVS | | OriGene shRNA RFP for MAVS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAVS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAVS | | | OriGene Protein Over-expression Lysate for MAVS | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MAVS | | OriGene 3'-UTR Clone for MAVS | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAVS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAVS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MAVS | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MAVS | | OriGene Custom Protein Services for MAVS | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAVS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAVS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAVS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAVS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAVS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAVS |
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| | Antibodies & Assays for MAVS |
| | | | Search Tocris compounds for MAVS |
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 | | | MAVS Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAVS |
|  |  |  | | | | ThermoFisher Antibody for MAVS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAVS |
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Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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