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MAVS Gene

protein-coding   GIFtS: 61
GCID: GC20P003827

Mitochondrial Antiviral Signaling Protein

  See MAVS-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrial Antiviral Signaling Protein1 2     Virus-Induced-Signaling Adapter2 3
IPS12 3 5     IPS-12 3
VISA2 3 5     CARD Adapter Inducing Interferon Beta2 3
CARD Adaptor Inducing IFN-Beta1 2     CARDIF2 5
IFN-B Promoter Stimulator 11 2     KIAA12713 5
Virus-Induced Signaling Adaptor1 2     Mitochondrial Antiviral-Signaling Protein2
Interferon Beta Promoter Stimulator Protein 12 3     Cardif3
Putative NF-Kappa-B-Activating Protein 031N2 3     

External Ids:    HGNC: 292331   Entrez Gene: 575062   Ensembl: ENSG000000888887   OMIM: 6096765   UniProtKB: Q7Z4343   

Export aliases for MAVS gene to outside databases

Previous GC identifers: GC20P003783 GC20P003784


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAVS Gene:
This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It
is required for activation of transcription factors which regulate expression of beta interferon and contributes
to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Sep 2011)

GeneCards Summary for MAVS Gene:
MAVS (mitochondrial antiviral signaling protein) is a protein-coding gene. Diseases associated with MAVS include chikungunya. GO annotations related to this gene include protein kinase binding and CARD domain binding.

UniProtKB/Swiss-Prot: MAVS_HUMAN, Q7Z434
Function: Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which
detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of
NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES
(CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral
infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide
short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with
delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following
detection of extracellular dsRNA by TLR3. May protect cells from apoptosis

Gene Wiki entry for MAVS (VISA) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAVS gene promoter:
         c-Fos   RFX1   AP-1   JunB   FosB   Fra-1   JunD   FOXJ2 (long isoform)   FOXJ2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAVS promoter sequence
   Search Chromatin IP Primers for MAVS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAVS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

MAVS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAVS gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P003827:  view genomic region     (about GC identifiers)

Start:
3,827,446 bp from pter      End:
3,856,770 bp from pter
Size:
29,325 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MAVS_HUMAN, Q7Z434 (See protein sequence)
Recommended Name: Mitochondrial antiviral-signaling protein  
Size: 540 amino acids; 56528 Da
Subunit: Interacts with DDX58/RIG-I, IFIH1/MDA5, TRAF2, TRAF6 and C1QBP. May interact with IRF3, FADD, RIPK1, CHUK
and IKBKB. Interacts with and is cleaved by HCV and hepatitis GB virus B NS3/4A proteases. Interacts with and is
cleaved by HHAV protein 3ABC. Interacts with NLRX1. Interaction with NLRX1 requires the CARD domain. Interacts
with PSMA7. Interacts with TRAFD1 (By similarity). Interacts (via C-terminus) with PCBP2 in a complex containing
MAVS/IPS1, PCBP2 and ITCH. Interacts with CYLD. Interacts with SRC. Interacts with DHX58/LGP2 and IKBKE.
Interacts with TMEM173/MITA. Interacts with IFIT3 (via N-terminus). Interacts with TBK1 only in the presence of
IFIT3. Interacts with MUL1. Interacts with human respiratory syncytial virus (HRSV) NS1 protein; this interaction
disrupts MAVS binding to DDX58/RIG-I
Miscellaneous: Cleavage by HCV protease complex leads to inactivation
Sequence caution: Sequence=BAA86585.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB14684.1; Type=Frameshift; Positions=333;
1 PDB 3D structure from and Proteopedia for MAVS:
2VGQ (3D)    
Secondary accessions: A8K6X0 B2BD33 B2BD34 F5H6C8 Q2HWT5 Q3I0Y2 Q5T7I6 Q86VY7 Q9H1H3 Q9H4Y1
Q9H8D3 Q9ULE9
Alternative splicing: 6 isoforms:  Q7Z434-1   Q7Z434-2   Q7Z434-3   Q7Z434-4   Q7Z434-5   Q7Z434-6   (Selectively activates an IFNbeta but not an IL8 promoter. Interacts with RIP1 and FADD and exhibits anti-viral activity against VSV infection)

Explore the universe of human proteins at neXtProt for MAVS: NX_Q7Z434

Explore proteomics data for MAVS at MOPED

Post-translational modifications: 

  • Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination catalyzed by ITCH; ITCH-dependent polyubiquitination
    is mediated by the interaction with PCBP2 and leads to MAVS/IPS1 proteasomal degradation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MAVS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001193420.1  NP_065797.2  

    ENSEMBL proteins: 
     ENSP00000401980   ENSP00000350852   ENSP00000413749  
    Reactome Protein details: Q7Z434

    MAVS Human Recombinant Protein Products:

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    Novus Biologicals MAVS Proteins
    Novus Biologicals MAVS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MAVS
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MAVS 

     
    antibodies-online proteins for MAVS (4 products) 

     
    antibodies-online peptides for MAVS

    MAVS Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAVS
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    ThermoFisher Antibody for MAVS
    antibodies-online antibodies for MAVS (76 products) 

    MAVS Assay Products:

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    Browse Enzo Life Sciences for kits & assays
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    Search eBioscience for ELISAs for MAVS 
    antibodies-online kits for MAVS (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026148 Mt_antiviral_sig_pro

    Graphical View of Domain Structure for InterPro Entry Q7Z434

    ProtoNet protein and cluster: Q7Z434

    UniProtKB/Swiss-Prot: MAVS_HUMAN, Q7Z434
    Domain: Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible
    for interaction with DDX58/RIG-I and IFIH1/MDA5
    Domain: The transmembrane domain and residues 300-444 are essential for its interaction with DHX58/LGP2
    Similarity: Contains 1 CARD domain


    Find genes that share domains with MAVS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAVS_HUMAN, Q7Z434
    Function: Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which
    detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of
    NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES
    (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral
    infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide
    short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with
    delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following
    detection of extracellular dsRNA by TLR3. May protect cells from apoptosis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding IPI16127453
    GO:0019901protein kinase binding IPI16127453
    GO:0050700CARD domain binding IPI16127453
         
    Find genes that share ontologies with MAVS           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Mavs):
     cardiovascular system  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  muscle  nervous system  respiratory system 

    Find genes that share phenotypes with MAVS           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MAVS: Mavstm1Camb Mavstm1Aki Mavstm1Itl Mavstm1Tsc Mavstm1Zjc Mavstm1Tsse

       genOway: Develop your customized and physiologically relevant rodent model for MAVS

    miRNA
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    miRTarBase miRNAs that target MAVS:
    hsa-mir-155-5p (MIRT020812), hsa-mir-92a-3p (MIRT049317), hsa-mir-186-5p (MIRT045289)

    Block miRNA regulation of human, mouse, rat MAVS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAVS (see all 29):
    hsa-miR-3678-3p hsa-miR-125a-5p hsa-miR-300 hsa-miR-4328 hsa-miR-330-5p hsa-miR-125a-3p hsa-miR-539 hsa-miR-488
    SwitchGear 3'UTR luciferase reporter plasmidMAVS 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MAVS

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): MAVS (NM_020746)
    Sino Biological Human cDNA Clone for MAVS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAVS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAVS
    Addgene plasmids for MAVS 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAVS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAVS_HUMAN, Q7Z434: Mitochondrion outer membrane. Mitochondrion. Peroxisome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    peroxisome5
    nucleus2
    cytosol1
    plasma membrane1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005741mitochondrial outer membrane TAS--
    GO:0005777peroxisome ----
    GO:0005778peroxisomal membrane IDA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with MAVS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAVS About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    TRAF6 mediated IRF7 activation0.40
    RIG-I-like receptor signaling pathway0.47
    TRAF3-dependent IRF activation pathway0.00
    Negative regulators of RIG-I/MDA5 signaling0.42
    NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -100.00
    2Cytosolic sensors of pathogen-associated DNA
    TRAF6 mediated NF-kB activation0.55
    Cytosolic DNA-sensing pathway0.33
    3Influenza A
    Influenza A0.34
    Herpes simplex infection0.33
    Measles0.34
    4Toll-like receptor signaling pathway
    Hepatitis B0.31
    5NF-kappaB Signaling
    NF-kappaB Signaling


    Find genes that share SuperPaths with MAVS           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MAVS
        NF-kappaB Signaling


    Selected Reactome Pathways for MAVS (see all 6)
        NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
    TRAF3-dependent IRF activation pathway
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    Negative regulators of RIG-I/MDA5 signaling
    TRAF6 mediated IRF7 activation


    Selected Kegg Pathways  (Kegg details for MAVS) (see all 7):
        RIG-I-like receptor signaling pathway
    Cytosolic DNA-sensing pathway
    Hepatitis C
    Hepatitis B
    Measles

        Pathway & Disease-focused RT2 Profiler PCR Array including MAVS: 
              Antiviral Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAVS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAVS (Q7Z4341, 2, 3 ENSP000004019804) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005191, 2, 3, ENSP000003614234EBI-995373,EBI-375543 MINT-7297542 MINT-7297557 MINT-7297574 MINT-7297526 MINT-7297498 MINT-7297511 I2D: score=2 STRING: ENSP00000361423
    MFN1Q8IWA41, 2, 3, ENSP000002639694EBI-995373,EBI-1048197 MINT-7714001 MINT-7713992 I2D: score=2 STRING: ENSP00000263969
    ENSG00000096155P463791, 3EBI-995373,EBI-347552 I2D: score=1 
    ENSG00000227761P463791, 3EBI-995373,EBI-347552 I2D: score=1 
    ENSG00000228760P463791, 3EBI-995373,EBI-347552 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation IDA16127453
    GO:0002218activation of innate immune response IMP18818105
    GO:0002230positive regulation of defense response to virus by host IMP19609254
    GO:0007165signal transduction IMP--
    GO:0016032viral process IEA--

    Find genes that share ontologies with MAVS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for MAVS



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAVS gene (2 alternative transcripts): 
    NM_001206491.1  NM_020746.4  

    Unigene Cluster for MAVS:

    Mitochondrial antiviral signaling protein
    Hs.570362  [show with all ESTs]
    Unigene Representative Sequence: NM_020746
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000428216(uc002wjv.3 uc002wjx.4 uc002wjw.4 uc002wjy.4)
    ENST00000358134 ENST00000416600
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    hsa-miR-3678-3p hsa-miR-125a-5p hsa-miR-300 hsa-miR-4328 hsa-miR-330-5p hsa-miR-125a-3p hsa-miR-539 hsa-miR-488
    SwitchGear 3'UTR luciferase reporter plasmidMAVS 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for MAVS 
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      QuantiTect SYBR Green Assays in human, mouse, rat MAVS
      QuantiFast Probe-based Assays in human, mouse, rat MAVS

    Additional mRNA sequence: 

    AB033097.1 AB097003.1 AB232371.1 AK023799.1 AK056260.1 AK092705.1 AK095370.1 AK123956.1 
    AK130992.1 AK291785.1 AK296897.1 AL390136.1 BC000073.2 BC028962.1 BC040719.1 BC040930.1 
    BC044952.1 BC052583.1 BC062310.1 BC063593.1 BX649084.1 DQ167126.1 DQ174270.1 DQ181928.1 
    EF467323.1 EF467324.1 NR_037921.1 

    17 DOTS entries:

    DT.406159  DT.40199115  DT.121644534  DT.101980187  DT.100778842  DT.120824788  DT.99932965  DT.86846786 
    DT.92420181  DT.97823592  DT.100778843  DT.111458  DT.100778841  DT.75101330  DT.92032322  DT.92422048 
    DT.92013360 

    Selected AceView cDNA sequences (see all 331):

    CR613265 BU185620 AA421036 T07608 BQ643957 AI743334 AI884661 BQ774259 
    AX775775 BM476249 AL135056 AW615403 AA558474 BX504554 CB055222 AA442990 
    AI653175 AI741608 CA413168 CB142810 BM709876 BU188769 AI092229 AA421037 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAVS (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
    SP1:        -                       -                                             
    SP2:        -           -           -                                             
    SP3:                    -           -                                             
    SP4:        -           -     -     -                                             
    SP5:        -           -     -     -     -                                       


    ECgene alternative splicing isoforms for MAVS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MAVS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGGCAGAG
    MAVS Expression
    About this image


    MAVS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    MAVS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAVS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.570362

    UniProtKB/Swiss-Prot: MAVS_HUMAN, Q7Z434
    Tissue specificity: Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level).
    Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood
    leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including MAVS: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MAVS gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mavs1 , 5 mitochondrial antiviral signaling protein1, 5 69.74(n)1
    55.44(a)1
      2 (63.30 cM)5
    2286071  NM_001206385.11  NP_001193314.11 
     1312340635 
    chicken
    (Gallus gallus)
    Aves MAVS6
    Gallus gallus mitochondrial antiviral signaling pr...
    17(a)
    1 ↔ 1
    4(88059162-88064033)
    zebrafish
    (Danio rerio)
    Actinopterygii mavs6
    mitochondrial antiviral signaling protein
    16(a)
    1 ↔ 1
    13(15136148-15167556) ENSDARG00000069733


    ENSEMBL Gene Tree for MAVS (if available)
    TreeFam Gene Tree for MAVS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAVS (see all 874)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1116234231,2
    C--3768672(+) CAAAC-/AAAAAA 3 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs735723491,2
    C--3768699(+) GTCACC/TGAGTA 3 -- us2k12Minor allele frequency- T:0.21WA 120
    rs1476546301,2
    C--3768768(+) TGGCTC/TACGCC 3 -- us2k10--------
    rs790614581,2
    C--3768770(+) GCTCAC/TGCCTG 3 -- us2k10--------
    rs1423086901,2
    --3768861(+) AACCTC/TGTCTC 3 -- us2k10--------
    rs778646131,2
    C,F--3769072(+) GGCTCG/ATGGGT 3 -- us2k15Minor allele frequency- A:0.08WA CSA NA 244
    rs1512831601,2
    --3769198(+) CTGTTG/TCCCTA 3 -- us2k10--------
    rs60844921,2
    C,H--3769216(+) tttcaG/Aatcat 3 -- us2k16Minor allele frequency- A:0.00NS EA NA 402
    rs1405392281,2
    --3769226(+) TGAGCC/TTTTGA 3 -- us2k10--------
    rs1155726631,2
    C,F--3769232(+) TTTGAT/CAGGAA 3 -- us2k12Minor allele frequency- C:0.05WA NA 238

    HapMap Linkage Disequilibrium report for MAVS (3827446 - 3856770 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MAVS:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv521026CNV Loss19592680
    nsv522507CNV Loss19592680
    nsv912622CNV Loss21882294
    nsv527710CNV Loss19592680
    nsv833899CNV Loss17160897
    nsv520430CNV Loss19592680
    nsv828673CNV Gain20364138

    Human Gene Mutation Database (HGMD): MAVS
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAVS
    DNA2.0 Custom Variant and Variant Library Synthesis for MAVS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609676    OMIM disorders: --

    1 disease for MAVS:    
    About MalaCards
    chikungunya


    Find genes that share disorders with MAVS           About GenesLikeMe

    3 Novoseek inferred disease relationships for MAVS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 60.1 3 16125763 (1), 16585524 (1), 20044805 (1)
    melanoma 42.9 1 19669308 (1)
    hepatitis c 29.6 3 16585524 (1), 17517627 (1)

    Genetic Association Database (GAD): MAVS
    Human Genome Epidemiology (HuGE) Navigator: MAVS (4 documents)

    Export disorders for MAVS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAVS gene, integrated from 10 sources (see all 151):
    (articles sorted by number of sources associating them with MAVS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. (PubMed id 16125763)1, 2, 3, 9 Seth R.B.... Chen Z.J. (Cell 2005)
    2. VISA is an adapter protein required for virus-triggered IFN-beta Signaling. (PubMed id 16153868)1, 2, 3 Xu L.-G.... Shu H.-B. (Mol. Cell 2005)
    3. Identification of MAVS splicing variants that interfere with RIGI/MAVS pathway signaling. (PubMed id 18207245)1, 2, 9 Lad S.P.... Li E. (Mol. Immunol. 2008)
    4. Mitochondrially localised MUL1 is a novel modulator of antiviral signaling. (PubMed id 23399697)1, 2 Jenkins K....Mansell A. (Immunol. Cell Biol. 2013)
    5. Respiratory syncytial virus NS1 protein colocalizes with mitochondrial antiviral signaling protein MAVS following infection. (PubMed id 22383950)1, 2 Boyapalle S.... Mohapatra S. (PLoS ONE 2012)
    6. IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1. (PubMed id 21813773)1, 2 Liu X.Y.... Wang C. (J. Immunol. 2011)
    7. Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. (PubMed id 20159242)1, 4 Li X....Bleecker E.R. (J. Allergy Clin. Immunol. 2010)
    8. Negative regulation of MAVS-mediated innate immune response by PSMA7. (PubMed id 19734229)1, 2 Jia Y.... Zhong H. (J. Immunol. 2009)
    9. PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. (PubMed id 19881509)1, 2 You F.... Jiang Z. (Nat. Immunol. 2009)
    10. The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling. (PubMed id 19419966)1, 2 Johnsen I.B....Anthonsen M.W. (J. Biol. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57506 HGNC: 29233 AceView: KIAA1271 Ensembl:ENSG00000088888 euGenes: HUgn57506
    ECgene: MAVS Kegg: 57506 H-InvDB: MAVS

    (According to HUGE)
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    HUGE: KIAA1271

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAVS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAVS gene:
    Search GeneIP for patents involving MAVS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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