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MATN4 Gene

protein-coding   GIFtS: 57
GCID: GC20M043922

Matrilin 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Matrilin 41 2
matrilin-42

External Ids:    HGNC: 69101   Entrez Gene: 87852   Ensembl: ENSG000001241597   OMIM: 6038975   UniProtKB: O954603   

Export aliases for MATN4 gene to outside databases

Previous GC identifers: GC20M043650 GC20M044560 GC20M044607 GC20M043355 GC20M040663


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MATN4 Gene:
This gene encodes a member of von Willebrand factor A domain-containing protein family. The proteins of this
family are thought to be involved in the formation of filamentous networks in the extracellular matrices of
various tissues. This family member is thought to be play a role in reorganizing and regenerating the corneal
matrix in granular and lattice type I dystrophies. It may also be involved in wound healing in the dentin-pulp
complex. Alternative splicing results in multiple transcript variants. (provided by RefSeq, May 2013)

GeneCards Summary for MATN4 Gene:
MATN4 (matrilin 4) is a protein-coding gene. An important paralog of this gene is VWA1.

UniProtKB/Swiss-Prot: MATN4_HUMAN, O95460
Function: Major component of the extracellular matrix of cartilage




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MATN4 gene promoter:
         HTF   Pax-2   Olf-1   Pax-2a   LCR-F1   AREB6   GATA-6   Ik-2   c-Myc   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMATN4 promoter sequence
   Search Chromatin IP Primers for MATN4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MATN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.1-q13.2   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.1-q13.2

MATN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MATN4 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M043922:  view genomic region     (about GC identifiers)

Start:
43,922,085 bp from pter      End:
43,937,169 bp from pter
Size:
15,085 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MATN4_HUMAN, O95460 (See protein sequence)
Recommended Name: Matrilin-4 precursor  
Size: 622 amino acids; 68487 Da
Subunit: Interacts with COMP
Sequence caution: Sequence=BAC11081.1; Type=Erroneous initiation;
Secondary accessions: A6NH94 A6NKN5 Q5QPU2 Q5QPU3 Q5QPU4 Q8N2M5 Q8N2M7 Q9H1F8 Q9H1F9
Alternative splicing: 4 isoforms:  O95460-1   O95460-2   O95460-3   O95460-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MATN4: NX_O95460

Explore proteomics data for MATN4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn69, Asn251, Asn305
  • Modification sites at PhosphoSitePlus

  • See MATN4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_003824.2  NP_085080.1  NP_085095.1  

    ENSEMBL proteins: 
     ENSP00000361842   ENSP00000361840   ENSP00000353819   ENSP00000343164   ENSP00000243983  
     ENSP00000440328   ENSP00000361837  
    Reactome Protein details: O95460

    MATN4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MATN4

     
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    antibodies-online proteins for MATN4 (2 products) 

     
    antibodies-online peptides for MATN4

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    Cloud-Clone Corp. CLIAs for MATN4
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    antibodies-online kits for MATN4 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR000742 EG-like_dom
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR019466 Matrilin_coiled-coil_trimer
     IPR009030 Growth_fac_rcpt_N_dom
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry O95460

    ProtoNet protein and cluster: O95460

    1 Blocks protein domain: IPB000152 Aspartic acid and asparagine hydroxylation site

    UniProtKB/Swiss-Prot: MATN4_HUMAN, O95460
    Similarity: Contains 4 EGF-like domains
    Similarity: Contains 2 VWFA domains


    Find genes that share domains with MATN4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MATN4_HUMAN, O95460
    Function: Major component of the extracellular matrix of cartilage

         Genatlas biochemistry entry for MATN4:
    matrilin 4,cartilage matrix protein

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding ----
    GO:0005515protein binding IPI15075323
         
    Find genes that share ontologies with MATN4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MATN4:
     Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MATN4

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate MATN4:
    hsa-miR-3658 hsa-miR-3065-5p hsa-miR-4258
    SwitchGear 3'UTR luciferase reporter plasmidMATN4 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for MATN4
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MATN4

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MATN4_HUMAN, O95460: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    golgi apparatus1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    Find genes that share ontologies with MATN4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MATN4 About    
    See pathways by source

    SuperPathContained pathways About
    1Degradation of the extracellular matrix
    Extracellular matrix organization0.34
    2ECM proteoglycans
    ECM proteoglycans
    3Articular Cartilage Extracellular Matrix
    Articular Cartilage Extracellular Matrix


    Find genes that share SuperPaths with MATN4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for MATN4
        Articular Cartilage Extracellular Matrix



    1 Reactome Pathway for MATN4
        ECM proteoglycans


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MATN4
    Interactions:

        Search GeneGlobe Interaction Network for MATN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for MATN4 (O954603 ENSP000003431644) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MATN2O003393, ENSP000002548984I2D: score=2 STRING: ENSP00000254898
    HAX1O001653, ENSP000003290024I2D: score=1 STRING: ENSP00000329002
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    MATN1P219413, ENSP000003628704I2D: score=2 STRING: ENSP00000362870
    MATN3O152323, ENSP000003838944I2D: score=2 STRING: ENSP00000383894
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030198extracellular matrix organization TAS--
    GO:0048678response to axon injury IEA--

    Find genes that share ontologies with MATN4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MATN4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MATN4 gene (3 alternative transcripts): 
    NM_003833.4  NM_030590.3  NM_030592.3  

    Unigene Cluster for MATN4:

    Matrilin 4
    Hs.278489  [show with all ESTs]
    Unigene Representative Sequence: BC151219
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372756 ENST00000372754 ENST00000360607(uc002xno.2) ENST00000342716(uc010zwr.1 uc002xnn.2)
    ENST00000353917(uc002xnp.2) ENST00000537548(uc002xnr.1) ENST00000372751

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate MATN4:
    hsa-miR-3658 hsa-miR-3065-5p hsa-miR-4258
    SwitchGear 3'UTR luciferase reporter plasmidMATN4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MATN4
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    GenScript: all cDNA clones in your preferred vector (see all 3): MATN4 (NM_030590)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MATN4
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      QuantiTect SYBR Green Assays in human, mouse, rat MATN4
      QuantiFast Probe-based Assays in human, mouse, rat MATN4

    Additional mRNA sequence: 

    AJ007581.1 AK027323.1 AK074495.1 AK074593.1 AK074597.1 BC131763.1 BC141811.1 BC143625.1 
    BC151219.1 

    4 DOTS entries:

    DT.100019914  DT.200264  DT.100019913  DT.100019912 

    18 AceView cDNA sequences:

    AK027323 NM_030592 NM_030590 AU279520 AK074595 AK074495 CA418769 NM_003833 
    AJ007581 BG477756 AK074597 BX283574 AI638341 AW134923 AK074593 AI038302 
    AA992948 H54037 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MATN4    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                                                  
    SP2:                    -                                             


    ECgene alternative splicing isoforms for MATN4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MATN4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MATN4 Expression
    About this image


    MATN4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 10 entries
             Zeugopod Epiphyseal End
             Micromass-induced chondrocytes
     
     Cartilage (Muscoskeletal System)    fully expand to see all 9 entries
             Micromass-induced chondrocytes
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
    MATN4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MATN4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.278489

    UniProtKB/Swiss-Prot: MATN4_HUMAN, O95460
    Tissue specificity: Embryonic kidney, lung and placenta

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MATN4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Matn41 , 5 matrilin 41, 5 86.89(n)1
    90.83(a)1
      2 (85.16 cM)5
    171831  NM_013592.41  NP_038620.21 
     1643893935 
    chicken
    (Gallus gallus)
    Aves MATN41 matrilin 4 72.98(n)
    71.66(a)
      428140  XM_425698.4  XP_425698.4 
    lizard
    (Anolis carolinensis)
    Reptilia MATN46
    matrilin 4
    64(a)
    1 ↔ 1
    4(143063653-143082056)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004928401 matrilin-4-like 61.1(n)
    63.88(a)
      100492840  XM_004918653.1  XP_004918710.1 
    zebrafish
    (Danio rerio)
    Actinopterygii matn46
    matrilin 4
    39(a)
    1 ↔ 1
    6(52742715-52798860) ENSDARG00000015947
    worm
    (Caenorhabditis elegans)
    Secernentea mup-46
    Protein MUP-4 (mup-4) mRNA, complete cds
    8(a)
    1 → many
    III(7479681-7489075) WBGene00003497


    ENSEMBL Gene Tree for MATN4 (if available)
    TreeFam Gene Tree for MATN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MATN4 gene
    VWA12  COL14A12  MATN32  MATN22  VIT2  COL12A12  COCH2  COL20A12  
    VWA22  MATN12  
    6 SIMAP similar genes for MATN4 using alignment to 4 protein entries:     MATN4_HUMAN (see all proteins):
    MATN3    COL21A1    PROS1    MATN1    HMCN1    MATN2

    Find genes that share paralogs with MATN4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MATN4 (see all 391)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs731147501,2
    --43921659(+) CAAAGC/TTCATC 3 -- ds50010--------
    rs27433711,2
    C,F,A,H--43921742(+) CCCCTT/CACCAG 3 -- ds500111Minor allele frequency- C:0.32NA WA CSA EA 372
    rs1917389061,2
    --43921803(+) GCGTGA/GCCGGG 3 -- ds50010--------
    rs27433741,2
    H--43921863(+) ACCCCA/GAGGAT 3 -- ds50012Minor allele frequency- G:0.00NS 208
    rs1169524791,2
    C,F--43922047(+) GGCTTC/TCCCTC 3 -- ds50012Minor allele frequency- T:0.05NA EA 240
    rs791182941,2
    C--43922241(+) TGGTCC/TGGGCG 3 -- ut312Minor allele frequency- T:0.05CSA WA 120
    rs22331081,2
    C,F--43922384(-) GACCCG/AGGCTG 3 -- ut31 ese31Minor allele frequency- A:0.05WA 118
    rs22331071,2
    C,F,A,H--43922403(-) GAGGGC/G/TCACGG 6 -- ut31 ese38NA WA CSA EA EU 746
    rs1457837391,2
    F--43922419(+) TGGTTG/AGCCAG 6 /A syn11Minor allele frequency- A:0.00NA 4052
    rs22331061,2
    C,F,H--43922428(-) GAGAAC/ACAGCT 6 /K /N mis117Minor allele frequency- A:0.04NS EA NA WA CSA 5852

    HapMap Linkage Disequilibrium report for MATN4 (43922085 - 43937169 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MATN4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912891CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MATN4
    DNA2.0 Custom Variant and Variant Library Synthesis for MATN4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603897    OMIM disorders: --


    Find genes that share disorders with MATN4           About GenesLikeMe


    Export disorders for MATN4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MATN4 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with MATN4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organisation, alternative splicing and primary structure of human matrilin-4. (PubMed id 9827539)1, 2, 3, 9 Wagener R.... Paulsson M. (FEBS Lett. 1998)
    2. Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias. (PubMed id 15075323)1, 2, 9 Mann H.H.... Wagener R. (J. Biol. Chem. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    5. Isolation and regional mapping of cDNAs expressed during early human development. (PubMed id 9027493)1, 3 Jay P....Berta P. (Genomics 1997)
    6. Proteolytic processing causes extensive heterogeneity of tissue matrilin forms. (PubMed id 19531486)1, 9 Ehlen H.W....Wagener R. (J. Biol. Chem. 2009)
    7. Comparative gene expression profile analysis between native human odontoblasts and pulp tissue. (PubMed id 18005044)1, 9 PAoAokkAPnen V....TjAoderhane L. (Int Endod J 2008)
    8. Characterization of the matrilin coiled-coil domains reveals seven novel isoforms. (PubMed id 11896063)1, 9 Frank S....Kammerer R.A. (J. Biol. Chem. 2002)
    9. Fibrillin-2, tenascin-C, matrilin-2, and matrilin-4 are strongly expressed in the epithelium of human granular and lattice type I corneal dystrophies. (PubMed id 22876117)1 Szalai E....Kaarniranta K. (Mol. Vis. 2012)
    10. Expression of matrilin-2 and -4 in human dental pulps during dentin-pulp complex wound healing. (PubMed id 21496664)1 Chen C....Xie N. (J Endod 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8785 HGNC: 6910 AceView: MATN4 Ensembl:ENSG00000124159 euGenes: HUgn8785
    ECgene: MATN4 H-InvDB: MATN4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MATN4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MATN4 gene:
    Search GeneIP for patents involving MATN4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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